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Conserved domains on  [gi|59676577|ref|NP_067337|]
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pappalysin-1 precursor [Mus musculus]

Protein Classification

LamGL and ZnMc_pappalysin_like domain-containing protein( domain architecture ID 13920446)

protein containing domains LamGL, ZnMc_pappalysin_like, myxo_disulf_rpt, and CCP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 421-657 7.02e-65

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


:

Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 219.90  E-value: 7.02e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  421 CDPECNHTLTGHDGgdcrqlryPAFMKKQQNGVCDMDCNYERFNFDGGECCDPDITDV---TKTCFDPDSPHRA-YLDVN 496
Cdd:cd04275    3 VIPVYFHVIYNNSA--------VSGGNISDAQITDQIDVLNDDYSGLNAGVDLGIEFVlagTTRTVNSAWPVFAgSGTED 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  497 ELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEA-LMHLGGIVLNPSFYGIPG-----HTHTMIHEIGHSLGLYHI 570
Cdd:cd04275   75 AMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLVSlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  571 FRGISeiqscsdpcmetePSFETGDLCNDTNPAPKHkFCGDPGpGNDTCGFHGFFnTPYNNFMSYADDDCTDSFTPNQVS 650
Cdd:cd04275  155 FQGGS-------------PCCTTGDYVADTPAEASP-SYGCPA-GRDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVT 218


                 ....*..
gi 59676577  651 RMHCYLD 657
Cdd:cd04275  219 RMRSYLD 225
LamGL smart00560
LamG-like jellyroll fold domain;
114-263 2.81e-32

LamG-like jellyroll fold domain;


:

Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 122.53  E-value: 2.81e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577     114 DAFTLQVWLRAEGGQKSPAVITGlydkcsytsrdrgWVMGIHTTSdqgNRDPRYFFSLKTDRarKVTTIDAHRSYLP-GQ 192
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIITG-------------AAVAQPTIS---EKALTFFLRAKSVQ--GWQTARTGATADWiGV 62

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59676577     193 WVHLAATYDG--RLMKLYMNGAQVATSAEQVGGIFSPLTQKCkvLMLGGSALNHNFRGHIEHFSLWKVARTQR 263
Cdd:smart00560   63 WVHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGG--RILLGGAGGENFSGRLDEVRVYNRALTAR 133
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 941-980 3.14e-13

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


:

Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 65.09  E-value: 3.14e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 59676577    941 SGYCGDGVIQKdqGEECDDMNKVNGDGCSLFCKQEVSFNC 980
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1412-1468 1.08e-10

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 1.08e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 59676577   1412 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGrgSNIIHCRKDGTWSGSFHVC 1468
Cdd:pfam00084    1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1544-1580 7.69e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.63  E-value: 7.69e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 59676577    1544 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 1580
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1343-1418 1.29e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 47.07  E-value: 1.29e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59676577 1343 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegtcvpvtcDPPPPK 1418
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 1187-1336 1.26e-04

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 45.80  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  1187 SSCQRGET----YSPAEQSCVHFACQAADcpelAVGNASLNCSSNHHYHGAQCTVSCQTGYVLqiqrddeliksqVGPSi 1262
Cdd:PHA02927  124 SYCELGSTgsmvWNPEAPICESVKCQSPP----SISNGRHNGYEDFYTDGSVVTYSCNSGYSL------------IGNS- 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59676577  1263 TVTCTEGKWNKQVACEPVDCGIPDHHHVYAASfSCPEGTTFGRRCSFQCRHPAQLKGNNSFlTCMEDGLWSfPE 1336
Cdd:PHA02927  187 GVLCSGGEWSDPPTCQIVKCPHPTISNGYLSS-GFKRSYSYNDNVDFKCKYGYKLSGSSSS-TCSPGNTWQ-PE 257
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 421-657 7.02e-65

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 219.90  E-value: 7.02e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  421 CDPECNHTLTGHDGgdcrqlryPAFMKKQQNGVCDMDCNYERFNFDGGECCDPDITDV---TKTCFDPDSPHRA-YLDVN 496
Cdd:cd04275    3 VIPVYFHVIYNNSA--------VSGGNISDAQITDQIDVLNDDYSGLNAGVDLGIEFVlagTTRTVNSAWPVFAgSGTED 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  497 ELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEA-LMHLGGIVLNPSFYGIPG-----HTHTMIHEIGHSLGLYHI 570
Cdd:cd04275   75 AMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLVSlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  571 FRGISeiqscsdpcmetePSFETGDLCNDTNPAPKHkFCGDPGpGNDTCGFHGFFnTPYNNFMSYADDDCTDSFTPNQVS 650
Cdd:cd04275  155 FQGGS-------------PCCTTGDYVADTPAEASP-SYGCPA-GRDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVT 218


                 ....*..
gi 59676577  651 RMHCYLD 657
Cdd:cd04275  219 RMRSYLD 225
LamGL smart00560
LamG-like jellyroll fold domain;
114-263 2.81e-32

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 122.53  E-value: 2.81e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577     114 DAFTLQVWLRAEGGQKSPAVITGlydkcsytsrdrgWVMGIHTTSdqgNRDPRYFFSLKTDRarKVTTIDAHRSYLP-GQ 192
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIITG-------------AAVAQPTIS---EKALTFFLRAKSVQ--GWQTARTGATADWiGV 62

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59676577     193 WVHLAATYDG--RLMKLYMNGAQVATSAEQVGGIFSPLTQKCkvLMLGGSALNHNFRGHIEHFSLWKVARTQR 263
Cdd:smart00560   63 WVHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGG--RILLGGAGGENFSGRLDEVRVYNRALTAR 133
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 107-265 1.94e-18

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 83.59  E-value: 1.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    107 ADLELPRDAFTLQVWLR-AEGGQKSPAVITGlydkcsytSRDRGWVMGIhttsdqgNRDPRYFFSLKTDRARkVTTIDAH 185
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKpDSLPGWARAIISS--------SGGGGYSLGL-------DGDGRLRFAVNGGNGG-WDTVTSG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    186 RSYLPGQWVHLAATYDGRLMKLYMNGAQVATSAeqvgGIFSPLTQKCKVLMLGGSA-LNHNFRGHIEHFSLWKVARTQRE 264
Cdd:pfam13385   74 ASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSST----LTGGPPPGTGGPLYIGRSPgGDDYFNGLIDEVRIYDRALSAAE 149


                   .
gi 59676577    265 I 265
Cdd:pfam13385  150 I 150
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 941-980 3.14e-13

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 65.09  E-value: 3.14e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 59676577    941 SGYCGDGVIQKdqGEECDDMNKVNGDGCSLFCKQEVSFNC 980
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1412-1468 1.08e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 1.08e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 59676577   1412 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGrgSNIIHCRKDGTWSGSFHVC 1468
Cdd:pfam00084    1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1544-1580 7.69e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.63  E-value: 7.69e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 59676577    1544 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 1580
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1343-1418 1.29e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 47.07  E-value: 1.29e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59676577 1343 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegtcvpvtcDPPPPK 1418
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
Sushi pfam00084
Sushi repeat (SCR repeat);
1343-1406 1.53e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 1.53e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59676577   1343 CLAPPPVPNADLQtarCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTQDGSWQEGT 1406
Cdd:pfam00084    1 CPPPPDIPNGKVS---ATKNEYNYGASVSYECDPGYRLVGSP--------TITCQEDGTWSPPF 53
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1412-1469 2.34e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 46.30  E-value: 2.34e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59676577 1412 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEdsdasQG---RGSNIIHCRKDGTWSGSFHVCR 1469
Cdd:cd00033    1 CPPPPVPENGTVTGSKGsYSYGSTVTYSCN-----EGytlVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1343-1407 1.15e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 1.15e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59676577    1343 CLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSW--QEGTC 1407
Cdd:smart00032    1 CPPPPDIENG---TVTSSSGTYSYGDTVTYSCDPGYTLIGSST--------ITCLENGTWspPPPTC 56
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 505-657 1.55e-05

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 46.84  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    505 DGSTHLNIFFANSSEEEL---AGVATWPWDKEALMHLGGIVLNPSF-YGIPGHTH---TMIHEIGHSLGLYHIFRGisei 577
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEG---- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    578 qSCSDPcmetepsfeTGDLCNDTnPAPKHKFCGDPGPGNDTCGFHGFFNTpynNFMSYadDDCTDSFTPNQVSRMHCYLD 657
Cdd:pfam05572   89 -GCERG---------EGDKVPDT-PSYTGGEVSLRNKDLFNCNGEPINSQ---NQMDY--NGCYAMFTQDQVDRMVEVLA 152
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1412-1468 4.81e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 4.81e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 59676577    1412 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSdaSQGRGSNIIHCRKDGTWSGSFHVC 1468
Cdd:smart00032    1 CPPPPDIENGTVTSSSGtYSYGDTVTYSCDPG--YTLIGSSTITCLENGTWSPPPPTC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 407-437 7.75e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 41.16  E-value: 7.75e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 59676577     407 ILANCDI----SKIGDEKCDPECNHTLTGHDGGDC 437
Cdd:smart00004    4 PWSRCEDaqcwDKFGDGVCDEECNNAECLWDGGDC 38
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 1187-1336 1.26e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 45.80  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  1187 SSCQRGET----YSPAEQSCVHFACQAADcpelAVGNASLNCSSNHHYHGAQCTVSCQTGYVLqiqrddeliksqVGPSi 1262
Cdd:PHA02927  124 SYCELGSTgsmvWNPEAPICESVKCQSPP----SISNGRHNGYEDFYTDGSVVTYSCNSGYSL------------IGNS- 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59676577  1263 TVTCTEGKWNKQVACEPVDCGIPDHHHVYAASfSCPEGTTFGRRCSFQCRHPAQLKGNNSFlTCMEDGLWSfPE 1336
Cdd:PHA02927  187 GVLCSGGEWSDPPTCQIVKCPHPTISNGYLSS-GFKRSYSYNDNVDFKCKYGYKLSGSSSS-TCSPGNTWQ-PE 257
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 91-218 1.71e-03

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 42.97  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577   91 SRALYFSGRGeQLRLRADLELPRDA---FTLQVWLRAEGGQKSpAVItglydkcsYTSRDRGwvmgihTTSDQGNRDPRY 167
Cdd:COG5306  172 GSGAQFDGTS-PLVVPASPSLALDAgggFTFSAWIKPAQLDGN-AVL--------YSRRDGA------NGLDNGAPFVEV 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 59676577  168 ffslkTDRARKVTTIDAhrSYLPGQWVHLAATYDGRLMKLYMNGAQVATSA 218
Cdd:COG5306  236 -----GGAGGTRSAAGA--PLAAGTWHHLAVVADAGKVTLYVNGVAAGSLD 279
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1282-1340 2.69e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.44  E-value: 2.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577 1282 CGIPDHhhVYAASFSCPEGT-TFGRRCSFQCRHPAQLKGNNSfLTCMEDGLWSFPEALCE 1340
Cdd:cd00033    1 CPPPPV--PENGTVTGSKGSySYGSTVTYSCNEGYTLVGSST-ITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1282-1339 4.11e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.12  E-value: 4.11e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 59676577    1282 CGIPDHhhVYAASFSCPEGT-TFGRRCSFQCRHPAQLKGNNSfLTCMEDGLWSFPEALC 1339
Cdd:smart00032    1 CPPPPD--IENGTVTSSSGTySYGDTVTYSCDPGYTLIGSST-ITCLENGTWSPPPPTC 56
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
 421-657 7.02e-65

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 219.90  E-value: 7.02e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  421 CDPECNHTLTGHDGgdcrqlryPAFMKKQQNGVCDMDCNYERFNFDGGECCDPDITDV---TKTCFDPDSPHRA-YLDVN 496
Cdd:cd04275    3 VIPVYFHVIYNNSA--------VSGGNISDAQITDQIDVLNDDYSGLNAGVDLGIEFVlagTTRTVNSAWPVFAgSGTED 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  497 ELKNILRLDGSTHLNIFFANSSEEELAGVATWPWDKEA-LMHLGGIVLNPSFYGIPG-----HTHTMIHEIGHSLGLYHI 570
Cdd:cd04275   75 AMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLVSlAFITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  571 FRGISeiqscsdpcmetePSFETGDLCNDTNPAPKHkFCGDPGpGNDTCGFHGFFnTPYNNFMSYADDDCTDSFTPNQVS 650
Cdd:cd04275  155 FQGGS-------------PCCTTGDYVADTPAEASP-SYGCPA-GRDTCPGQPGL-DPIHNYMDYSDDSCMNEFTPGQVT 218


                 ....*..
gi 59676577  651 RMHCYLD 657
Cdd:cd04275  219 RMRSYLD 225
LamGL smart00560
LamG-like jellyroll fold domain;
114-263 2.81e-32

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 122.53  E-value: 2.81e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577     114 DAFTLQVWLRAEGGQKSPAVITGlydkcsytsrdrgWVMGIHTTSdqgNRDPRYFFSLKTDRarKVTTIDAHRSYLP-GQ 192
Cdd:smart00560    1 GSFTLEAWVKLESAGGSQPIITG-------------AAVAQPTIS---EKALTFFLRAKSVQ--GWQTARTGATADWiGV 62

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59676577     193 WVHLAATYDG--RLMKLYMNGAQVATSAEQVGGIFSPLTQKCkvLMLGGSALNHNFRGHIEHFSLWKVARTQR 263
Cdd:smart00560   63 WVHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGG--RILLGGAGGENFSGRLDEVRVYNRALTAR 133
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 107-265 1.94e-18

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 83.59  E-value: 1.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    107 ADLELPRDAFTLQVWLR-AEGGQKSPAVITGlydkcsytSRDRGWVMGIhttsdqgNRDPRYFFSLKTDRARkVTTIDAH 185
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKpDSLPGWARAIISS--------SGGGGYSLGL-------DGDGRLRFAVNGGNGG-WDTVTSG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    186 RSYLPGQWVHLAATYDGRLMKLYMNGAQVATSAeqvgGIFSPLTQKCKVLMLGGSA-LNHNFRGHIEHFSLWKVARTQRE 264
Cdd:pfam13385   74 ASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSST----LTGGPPPGTGGPLYIGRSPgGDDYFNGLIDEVRIYDRALSAAE 149


                   .
gi 59676577    265 I 265
Cdd:pfam13385  150 I 150
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 941-980 3.14e-13

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 65.09  E-value: 3.14e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 59676577    941 SGYCGDGVIQKdqGEECDDMNKVNGDGCSLFCKQEVSFNC 980
Cdd:TIGR02232    1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
1412-1468 1.08e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 58.28  E-value: 1.08e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 59676577   1412 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGrgSNIIHCRKDGTWSGSFHVC 1468
Cdd:pfam00084    1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1544-1580 7.69e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 49.63  E-value: 7.69e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 59676577    1544 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 1580
Cdd:smart00004    1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1343-1418 1.29e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 47.07  E-value: 1.29e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 59676577 1343 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegtcvpvtcDPPPPK 1418
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
Sushi pfam00084
Sushi repeat (SCR repeat);
1343-1406 1.53e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 1.53e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59676577   1343 CLAPPPVPNADLQtarCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTQDGSWQEGT 1406
Cdd:pfam00084    1 CPPPPDIPNGKVS---ATKNEYNYGASVSYECDPGYRLVGSP--------TITCQEDGTWSPPF 53
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
 507-569 1.60e-06

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 50.11  E-value: 1.60e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  507 STHLNIFFANSSEEEL--AGVATWPWDKEALMHLGGIVLNPSFYGI---PG--HTHTMIHEIGHSLGLYH 569
Cdd:cd04277   60 NSGADIRFGNSSDPDGntAGYAYYPGSGSGTAYGGDIWFNSSYDTNsdsPGsyGYQTIIHEIGHALGLEH 129
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1412-1469 2.34e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 46.30  E-value: 2.34e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 59676577 1412 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEdsdasQG---RGSNIIHCRKDGTWSGSFHVCR 1469
Cdd:cd00033    1 CPPPPVPENGTVTGSKGsYSYGSTVTYSCN-----EGytlVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1343-1407 1.15e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 44.05  E-value: 1.15e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59676577    1343 CLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSW--QEGTC 1407
Cdd:smart00032    1 CPPPPDIENG---TVTSSSGTYSYGDTVTYSCDPGYTLIGSST--------ITCLENGTWspPPPTC 56
Peptidase_M43 pfam05572
Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a ...
 505-657 1.55e-05

Pregnancy-associated plasma protein-A; Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.


Pssm-ID: 368506  Cd Length: 152  Bit Score: 46.84  E-value: 1.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    505 DGSTHLNIFFANSSEEEL---AGVATWPWDKEALMHLGGIVLNPSF-YGIPGHTH---TMIHEIGHSLGLYHIFRGisei 577
Cdd:pfam05572   13 DNEKYMNVYIQNDLADGLtnnSGVAWYPDSGMSADGTARVVFNGAYlAADPTSTNfssTLTHEFGHFLGLIHTFEG---- 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577    578 qSCSDPcmetepsfeTGDLCNDTnPAPKHKFCGDPGPGNDTCGFHGFFNTpynNFMSYadDDCTDSFTPNQVSRMHCYLD 657
Cdd:pfam05572   89 -GCERG---------EGDKVPDT-PSYTGGEVSLRNKDLFNCNGEPINSQ---NQMDY--NGCYAMFTQDQVDRMVEVLA 152
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1412-1468 4.81e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 4.81e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 59676577    1412 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSdaSQGRGSNIIHCRKDGTWSGSFHVC 1468
Cdd:smart00032    1 CPPPPDIENGTVTSSSGtYSYGDTVTYSCDPG--YTLIGSSTITCLENGTWSPPPPTC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 407-437 7.75e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 41.16  E-value: 7.75e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 59676577     407 ILANCDI----SKIGDEKCDPECNHTLTGHDGGDC 437
Cdd:smart00004    4 PWSRCEDaqcwDKFGDGVCDEECNNAECLWDGGDC 38
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 1187-1336 1.26e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 45.80  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  1187 SSCQRGET----YSPAEQSCVHFACQAADcpelAVGNASLNCSSNHHYHGAQCTVSCQTGYVLqiqrddeliksqVGPSi 1262
Cdd:PHA02927  124 SYCELGSTgsmvWNPEAPICESVKCQSPP----SISNGRHNGYEDFYTDGSVVTYSCNSGYSL------------IGNS- 186

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 59676577  1263 TVTCTEGKWNKQVACEPVDCGIPDHHHVYAASfSCPEGTTFGRRCSFQCRHPAQLKGNNSFlTCMEDGLWSfPE 1336
Cdd:PHA02927  187 GVLCSGGEWSDPPTCQIVKCPHPTISNGYLSS-GFKRSYSYNDNVDFKCKYGYKLSGSSSS-TCSPGNTWQ-PE 257
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 1255-1468 7.13e-04

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 43.49  E-value: 7.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  1255 KSQVGPsITVTCTEGKWNKQVACEPVDCGIP---DHHHVYAAsfscpeGTTFGRRCSFQCRHPAQLKG-NNSFLTCMEDG 1330
Cdd:PHA02927   60 KQKMGP-IYAKCTGTGWTLFNQCIKRRCPSPrdiDNGQLDIG------GVDFGSSITYSCNSGYQLIGeSKSYCELGSTG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577  1331 --LWSfPEA-LCE-LMCLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTqDGSWQE-G 1405
Cdd:PHA02927  133 smVWN-PEApICEsVKCQSPPSISNG---RHNGYEDFYTDGSVVTYSCNSGYSLIGNS--------GVLCS-GGEWSDpP 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 59676577  1406 TCVPVTCdpPPPKFHGLYqCTNGFQ----FNSECRIKCEDSDASQGRGSNIihCRKDGTWSGSFHVC 1468
Cdd:PHA02927  200 TCQIVKC--PHPTISNGY-LSSGFKrsysYNDNVDFKCKYGYKLSGSSSST--CSPGNTWQPELPKC 261
MJ1470 COG5306
Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type ...
 91-218 1.71e-03

Uncharacterized conserved protein MJ1470, contains DUF2341 domain, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 444105 [Multi-domain]  Cd Length: 529  Bit Score: 42.97  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577   91 SRALYFSGRGeQLRLRADLELPRDA---FTLQVWLRAEGGQKSpAVItglydkcsYTSRDRGwvmgihTTSDQGNRDPRY 167
Cdd:COG5306  172 GSGAQFDGTS-PLVVPASPSLALDAgggFTFSAWIKPAQLDGN-AVL--------YSRRDGA------NGLDNGAPFVEV 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 59676577  168 ffslkTDRARKVTTIDAhrSYLPGQWVHLAATYDGRLMKLYMNGAQVATSA 218
Cdd:COG5306  236 -----GGAGGTRSAAGA--PLAAGTWHHLAVVADAGKVTLYVNGVAAGSLD 279
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1282-1340 2.69e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.44  E-value: 2.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 59676577 1282 CGIPDHhhVYAASFSCPEGT-TFGRRCSFQCRHPAQLKGNNSfLTCMEDGLWSFPEALCE 1340
Cdd:cd00033    1 CPPPPV--PENGTVTGSKGSySYGSTVTYSCNEGYTLVGSST-ITCTENGGWSPPPPTCE 57
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 536-573 2.72e-03

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 40.17  E-value: 2.72e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 59676577  536 MHLGGIVLNPSFYGIPGH--THTMIHEIGHSLGLYHIFRG 573
Cdd:cd04268   75 ILLARVYLYSSFVEYSGArlRNTAEHELGHALGLRHNFAA 114
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 1212-1272 3.28e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.44  E-value: 3.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 59676577 1212 CPEL-AVGNASLNCSSNHHYHGAQCTVSCQTGYVLqiqrddeliksqVGPSiTVTCTE-GKWN 1272
Cdd:cd00033    1 CPPPpVPENGTVTGSKGSYSYGSTVTYSCNEGYTL------------VGSS-TITCTEnGGWS 50
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 1282-1339 4.11e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.12  E-value: 4.11e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 59676577    1282 CGIPDHhhVYAASFSCPEGT-TFGRRCSFQCRHPAQLKGNNSfLTCMEDGLWSFPEALC 1339
Cdd:smart00032    1 CPPPPD--IENGTVTSSSGTySYGDTVTYSCDPGYTLIGSST-ITCLENGTWSPPPPTC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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