NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6166107|sp|P01035|]
View 

RecName: Full=Cystatin-C; AltName: Full=Colostrum thiol proteinase inhibitor; AltName: Full=Cystatin-3; Flags: Precursor

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 37-147 1.51e-32

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 110.98  E-value: 1.51e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166107      37 RLLGGLMEADVNEEGVQEALSFAVSEFNKRSNDAYQSRVVRVVRARKQVVSGMNYFLDVELGRTTCTKSQANLDSCPFHN 116
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 6166107     117 QPhlkrEKLCSFQVYVVPWMNTINLVKFSCQ 147
Cdd:smart00043  81 QG----EKFCTAKVWEKPWENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 37-147 1.51e-32

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 110.98  E-value: 1.51e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166107      37 RLLGGLMEADVNEEGVQEALSFAVSEFNKRSNDAYQSRVVRVVRARKQVVSGMNYFLDVELGRTTCTKSQANLDSCPFHN 116
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 6166107     117 QPhlkrEKLCSFQVYVVPWMNTINLVKFSCQ 147
Cdd:smart00043  81 QG----EKFCTAKVWEKPWENKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 40-135 3.43e-27

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 97.02  E-value: 3.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166107     40 GGLMEADVNEEGVQEALSFAVSEFNKRsNDAYQSRVVRVVRARKQVVSGMNYFLDVELGRTTCTKSQANLDSCPFHNQph 119
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAK-TDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDE-- 77

                          90
                  ....*....|....*.
gi 6166107    120 lKREKLCSFQVYVVPW 135
Cdd:pfam00031  78 -KWLGLCSAQVYKVPW 92
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 40-146 4.84e-27

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 97.16  E-value: 4.84e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166107   40 GGLMEADVNEEGVQEALSFAVSEFNKRSNDAYqSRVVRVVRARKQVVSGMNYFLDVELGRTTCTKSQANLDsCPFHNQPH 119
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 6166107  120 LKREKLCSFQVYVVPWMNTINLVKFSC 146
Cdd:cd00042  79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 37-147 1.51e-32

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 110.98  E-value: 1.51e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166107      37 RLLGGLMEADVNEEGVQEALSFAVSEFNKRSNDAYQSRVVRVVRARKQVVSGMNYFLDVELGRTTCTKSQANLDSCPFHN 116
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 6166107     117 QPhlkrEKLCSFQVYVVPWMNTINLVKFSCQ 147
Cdd:smart00043  81 QG----EKFCTAKVWEKPWENKIKLVEFKCT 107
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 40-135 3.43e-27

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 97.02  E-value: 3.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166107     40 GGLMEADVNEEGVQEALSFAVSEFNKRsNDAYQSRVVRVVRARKQVVSGMNYFLDVELGRTTCTKSQANLDSCPFHNQph 119
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAK-TDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDE-- 77

                          90
                  ....*....|....*.
gi 6166107    120 lKREKLCSFQVYVVPW 135
Cdd:pfam00031  78 -KWLGLCSAQVYKVPW 92
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 40-146 4.84e-27

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 97.16  E-value: 4.84e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6166107   40 GGLMEADVNEEGVQEALSFAVSEFNKRSNDAYqSRVVRVVRARKQVVSGMNYFLDVELGRTTCTKSQANLDsCPFHNQPH 119
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 6166107  120 LKREKLCSFQVYVVPWMNTINLVKFSC 146
Cdd:cd00042  79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH