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Conserved domains on  [gi|61806462|ref|NP_001013463|]
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leucine-rich repeat-containing protein 1 [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-449 1.29e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 1.29e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  57 NLTKLRKLGLSDNEIQRLPGDIANFNQLVELDISRNDIMELPESISYCKTLQVADFSGNPLTRLPESFPELRNLACLSIN 136
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 137 DISLQALPDNIGNLCNLVSLELRENlltylpESLSQLQKLEELDVGSNELYNLPETIGCLVSLKDLWLDGNQLSDIPAEV 216
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 217 GSMRSLTCLDVSENKLERLPEEMGNLLSLTDLLVSQNLIDLLPEGIGKLKRLSILKADQNRLVQLPESIGHCESLTELVL 296
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 297 TENQLVNLPrSIGKLKKLSNFNCDRNRLASLPKEiGGCCSLNVLCVRENR-----LMRIPPELSQASELHVLDLSGNRLL 371
Cdd:COG4886 236 SNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQltdlkLKELELLLGLNSLLLLLLLLNLLEL 313

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61806462 372 YLPLTLTSLRLKALWLSENQSQPLLTFQTDVDPESGEKVLTCVLLPQQPCESENTGSDNLARCGALESLVESSILDDT 449
Cdd:COG4886 314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-449 1.29e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 1.29e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  57 NLTKLRKLGLSDNEIQRLPGDIANFNQLVELDISRNDIMELPESISYCKTLQVADFSGNPLTRLPESFPELRNLACLSIN 136
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 137 DISLQALPDNIGNLCNLVSLELRENlltylpESLSQLQKLEELDVGSNELYNLPETIGCLVSLKDLWLDGNQLSDIPAEV 216
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 217 GSMRSLTCLDVSENKLERLPEEMGNLLSLTDLLVSQNLIDLLPEGIGKLKRLSILKADQNRLVQLPESIGHCESLTELVL 296
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 297 TENQLVNLPrSIGKLKKLSNFNCDRNRLASLPKEiGGCCSLNVLCVRENR-----LMRIPPELSQASELHVLDLSGNRLL 371
Cdd:COG4886 236 SNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQltdlkLKELELLLGLNSLLLLLLLLNLLEL 313

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61806462 372 YLPLTLTSLRLKALWLSENQSQPLLTFQTDVDPESGEKVLTCVLLPQQPCESENTGSDNLARCGALESLVESSILDDT 449
Cdd:COG4886 314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-287 2.87e-29

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 122.50  E-value: 2.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   26 FVPDEIYryrgsleELLLDANQLRDLPKpffNL-TKLRKLGLSDNEIQRLPGDIANFNQlvELDISRNDIMELPESISyc 104
Cdd:PRK15370 196 CIPEQIT-------TLILDNNELKSLPE---NLqGNIKTLYANSNQLTSIPATLPDTIQ--EMELSINRITELPERLP-- 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  105 KTLQVADFSGNPLTRLPESFPElrNLACLSINDISLQALPDNIGNlcNLVSLELRENLLTYLPESLSQlqKLEELDVGSN 184
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLPP--GLKTLEAGEN 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  185 ELYNLPETIgclvslkdlwldgnqlsdiPAEvgsmrsLTCLDVSENKLERLPEEMGNllSLTDLLVSQNLIDLLPEGIGK 264
Cdd:PRK15370 336 ALTSLPASL-------------------PPE------LQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPA 388

                        250       260
                 ....*....|....*....|...
gi 61806462  265 lkRLSILKADQNRLVQLPESIGH 287
Cdd:PRK15370 389 --ALQIMQASRNNLVRLPESLPH 409
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 202-368 4.46e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 4.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 202 LWLDGNQLSDIPaEVGSMRSLTCLDVSENKLERLpEEMGNLLSLTDLLVSQNLIDLLpEGIGKLKRLSILKADQNRLVQL 281
Cdd:cd21340   7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 282 pESIGHCESLTELVLtENQ-------LVNLPRSIGKLKK-LSNFNCDRNRLASLpKEIGGCCSLNVLCVRENRLMRIP-- 351
Cdd:cd21340  84 -EGLENLTNLEELHI-ENQrlppgekLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEel 160

                       170
                ....*....|....*...
gi 61806462 352 -PELSQASELHVLDLSGN 368
Cdd:cd21340 161 lDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
37-94 1.17e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462    37 SLEELLLDANQLRDL-PKPFFNLTKLRKLGLSDNEIQRL-PGDIANFNQLVELDISRNDI 94
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-449 1.29e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 1.29e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  57 NLTKLRKLGLSDNEIQRLPGDIANFNQLVELDISRNDIMELPESISYCKTLQVADFSGNPLTRLPESFPELRNLACLSIN 136
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 137 DISLQALPDNIGNLCNLVSLELRENlltylpESLSQLQKLEELDVGSNELYNLPETIGCLVSLKDLWLDGNQLSDIPAEV 216
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 217 GSMRSLTCLDVSENKLERLPEEMGNLLSLTDLLVSQNLIDLLPEGIGKLKRLSILKADQNRLVQLPESIGHCESLTELVL 296
Cdd:COG4886 156 GNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 297 TENQLVNLPrSIGKLKKLSNFNCDRNRLASLPKEiGGCCSLNVLCVRENR-----LMRIPPELSQASELHVLDLSGNRLL 371
Cdd:COG4886 236 SNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQltdlkLKELELLLGLNSLLLLLLLLNLLEL 313

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61806462 372 YLPLTLTSLRLKALWLSENQSQPLLTFQTDVDPESGEKVLTCVLLPQQPCESENTGSDNLARCGALESLVESSILDDT 449
Cdd:COG4886 314 LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-333 6.50e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.05  E-value: 6.50e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  36 GSLEELLLDANQLRDLPKPFFNLTKLRKLGLSDNEIQRLPGDIANFNQLVELDISRNdimelpESISYCKTLQVADFSGN 115
Cdd:COG4886  50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGN 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 116 PLTRLPESFPELRNLACLSINDISLQALPDNIGNLCNLVSLELRENLLTYLPESLSQLQKLEELDVGSNELYNLPETIGC 195
Cdd:COG4886 124 QLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGN 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 196 LVSLKDLWLDGNQLSDIPAEVGSMRSLTCLDVSENKLERLPeEMGNLLSLTDLLVSQNLIDLLPEgIGKLKRLSILKADQ 275
Cdd:COG4886 204 LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSN 281

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61806462 276 NRLVQLPESIGHCESLTELVLTENQLVNLPRSIGKLKKLSNFNCDRNRLASLPKEIGG 333
Cdd:COG4886 282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-287 2.87e-29

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 122.50  E-value: 2.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   26 FVPDEIYryrgsleELLLDANQLRDLPKpffNL-TKLRKLGLSDNEIQRLPGDIANFNQlvELDISRNDIMELPESISyc 104
Cdd:PRK15370 196 CIPEQIT-------TLILDNNELKSLPE---NLqGNIKTLYANSNQLTSIPATLPDTIQ--EMELSINRITELPERLP-- 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  105 KTLQVADFSGNPLTRLPESFPElrNLACLSINDISLQALPDNIGNlcNLVSLELRENLLTYLPESLSQlqKLEELDVGSN 184
Cdd:PRK15370 262 SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLPP--GLKTLEAGEN 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  185 ELYNLPETIgclvslkdlwldgnqlsdiPAEvgsmrsLTCLDVSENKLERLPEEMGNllSLTDLLVSQNLIDLLPEGIGK 264
Cdd:PRK15370 336 ALTSLPASL-------------------PPE------LQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPA 388

                        250       260
                 ....*....|....*....|...
gi 61806462  265 lkRLSILKADQNRLVQLPESIGH 287
Cdd:PRK15370 389 --ALQIMQASRNNLVRLPESLPH 409
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 13-391 8.24e-23

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 102.62  E-value: 8.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   13 HIEAIDRRHCSLLF-VPDEIYRYRGSLEELLLDANQLRDlPKPFFNLTKLRKLGLSDNEIQ-RLPGDIANFNQLVELDIS 90
Cdd:PLN00113  94 YIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   91 RNDIM-ELPESISYCKTLQVADFSGNPLT-RLPESFPELRNLAC--LSINDISLQaLPDNIGNLCNLVSLELRENLLT-Y 165
Cdd:PLN00113 173 GNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWiyLGYNNLSGE-IPYEIGGLTSLNHLDLVYNNLTgP 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  166 LPESLSQLQKLEELDVGSNELYN-LPETIGCLVSLKDLWLDGNQLS-DIPAEVGSMRSLTCLDVSENKLE-RLPEEMGNL 242
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSL 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  243 LSLTDL-LVSQNLIDLLPEGIGKLKRLSILKADQNRLV-QLPESIGHCESLTELVLTENQLVN-LPRSIGKLKKLSNFNC 319
Cdd:PLN00113 332 PRLQVLqLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRL 411

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61806462  320 DRNRLA-SLPKEIGGCCSLNVLCVRENRLM-RIPPELSQASELHVLDLSGNRLL-YLPLTLTSLRLKALWLSENQ 391
Cdd:PLN00113 412 QDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQ 486
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-379 1.51e-21

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 98.77  E-value: 1.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   80 NFNQLVELDISRNDIM-ELPESISYCKTLQVADFSGNPLT-RLPE----SFPELRNLAcLSINDISlQALPDniGNLCNL 153
Cdd:PLN00113  67 NSSRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDdiftTSSSLRYLN-LSNNNFT-GSIPR--GSIPNL 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  154 VSLELRENLLT-YLPESLSQLQKLEELDVGSNELY-NLPETIGCLVSLKDLWLDGNQLS-DIPAEVGSMRSLTCLDVSEN 230
Cdd:PLN00113 143 ETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYN 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  231 KLE-RLPEEMGNLLSLTDL-LVSQNLIDLLPEGIGKLKRLSILKADQNRLV-QLPESIGHCESLTELVLTENQLV-NLPR 306
Cdd:PLN00113 223 NLSgEIPYEIGGLTSLNHLdLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPE 302

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 61806462  307 SIGKLKKLSNFNCDRNRL-ASLPKEIGGCCSLNVLCVRENRLM-RIPPELSQASELHVLDLSGNRLL-YLPLTLTS 379
Cdd:PLN00113 303 LVIQLQNLEILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCS 378
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-337 7.09e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 7.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   38 LEELLLDANQLRD-LPKPFFNLTKLRKLGLSDNEIQ-RLPGDIANFNQLVELDISRNDIM-ELPESISYCKTLQVADFSG 114
Cdd:PLN00113 262 LQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWS 341

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  115 NPLT-RLPESFPELRNLACLSINDISLQA-LPDNIGNLCNLVSLELRENLL-TYLPESLSQLQKLEELDVGSNELY-NLP 190
Cdd:PLN00113 342 NKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELP 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  191 ETIGCLVSLKDLWLDGNQLS-DIPAEVGSMRSLTCLDVSENK-LERLPEEMGNlLSLTDLLVSQNLID-LLPEGIGKLKR 267
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKfFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSE 500

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61806462  268 LSILKADQNRLV-QLPESIGHCESLTELVLTENQLV-NLPRSIGKLKKLSNFNCDRNRLA-SLPKEIGGCCSL 337
Cdd:PLN00113 501 LMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
83-398 2.08e-16

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 82.52  E-value: 2.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   83 QLVELDISRNDIMELPESISYCKTLQVadfSGNPLTRLPESFPELRNLACLSINDISLQALPDnignlcNLVSLELRENL 162
Cdd:PRK15387 223 HITTLVIPDNNLTSLPALPPELRTLEV---SGNQLTSLPVLPPGLLELSIFSNPLTHLPALPS------GLCKLWIFGNQ 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  163 LTYLPESLSQLQkleELDVGSNELYNLPETIGclvSLKDLWLDGNQLSDIPAEVGSMRSLTcldVSENKLERLPEemgnl 242
Cdd:PRK15387 294 LTSLPVLPPGLQ---ELSVSDNQLASLPALPS---ELCKLWAYNNQLTSLPTLPSGLQELS---VSDNQLASLPT----- 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  243 lsltdllvsqnlidlLPEGIGKlkrlsiLKADQNRLVQLPesiGHCESLTELVLTENQLVNLPRSIGKLKKLSnfnCDRN 322
Cdd:PRK15387 360 ---------------LPSELYK------LWAYNNRLTSLP---ALPSGLKELIVSGNRLTSLPVLPSELKELM---VSGN 412

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61806462  323 RLASLPKEIGGCCSLNVLcvrENRLMRIPPELSQASELHVLDLSGNrllylPLTLTSLR-LKALWLSENQSQPLLTF 398
Cdd:PRK15387 413 RLTSLPMLPSGLLSLSVY---RNQLTRLPESLIHLSSETTVNLEGN-----PLSERTLQaLREITSAPGYSGPIIRF 481
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
139-390 4.01e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.59  E-value: 4.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  139 SLQALPDNIGNlcNLVSLELRENLLTYLPESLSQlqKLEELDVGSNELYNLPETIGClvSLKDLWLDGNQLSDIPAEVGS 218
Cdd:PRK15370 168 AVQRMRDCLKN--NKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPD 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  219 mrSLTCLDVSENKLERLPEEMGNllSLTDLLVSQNLIDLLPEGI-GKLKRLSILKadqNRLVQLPESIGhcESLTELVLT 297
Cdd:PRK15370 242 --TIQEMELSINRITELPERLPS--ALQSLDLFHNKISCLPENLpEELRYLSVYD---NSIRTLPAHLP--SGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  298 ENQLVNLPRSIGKlkKLSNFNCDRNRLASLPKEIggccslnvlcvrenrlmriPPELsqaselHVLDLSGNRLLYLPLTL 377
Cdd:PRK15370 313 SNSLTALPETLPP--GLKTLEAGENALTSLPASL-------------------PPEL------QVLDVSKNQITVLPETL 365

                        250
                 ....*....|...
gi 61806462  378 TSlRLKALWLSEN 390
Cdd:PRK15370 366 PP-TITTLDVSRN 377
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-253 1.23e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   36 GSLEELLLDANQLRD-LPKPFFNLTKLRKLGLSDNEIQ-RLPGDIANFNQLVELDISRNDIMELPESISY-CKTLQVADF 112
Cdd:PLN00113 380 GNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQGRINSRKWdMPSLQMLSL 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  113 SGNPLT-RLPESF--PELRNLAcLSINDISlQALPDNIGNLCNLVSLELRENLLT-YLPESLSQLQKLEELDVGSNELY- 187
Cdd:PLN00113 460 ARNKFFgGLPDSFgsKRLENLD-LSRNQFS-GAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSg 537

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61806462  188 NLPETIGCLVSLKDLWLDGNQLS-DIPAEVGSMRSLTCLDVSENKLERLPEEMGNLLSLTDLLVSQN 253
Cdd:PLN00113 538 QIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGN 604
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
23-128 3.63e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 3.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   23 SLLFVPDEIyryRGSLEELLLDANQLRDLPKPFfnLTKLRKLGLSDNEIQRLPGDIANfnQLVELDISRNDIMELPESIS 102
Cdd:PRK15370 315 SLTALPETL---PPGLKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLP 387

                         90       100
                 ....*....|....*....|....*.
gi 61806462  103 ycKTLQVADFSGNPLTRLPESFPELR 128
Cdd:PRK15370 388 --AALQIMQASRNNLVRLPESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 202-368 4.46e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 4.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 202 LWLDGNQLSDIPaEVGSMRSLTCLDVSENKLERLpEEMGNLLSLTDLLVSQNLIDLLpEGIGKLKRLSILKADQNRLVQL 281
Cdd:cd21340   7 LYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 282 pESIGHCESLTELVLtENQ-------LVNLPRSIGKLKK-LSNFNCDRNRLASLpKEIGGCCSLNVLCVRENRLMRIP-- 351
Cdd:cd21340  84 -EGLENLTNLEELHI-ENQrlppgekLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEel 160

                       170
                ....*....|....*...
gi 61806462 352 -PELSQASELHVLDLSGN 368
Cdd:cd21340 161 lDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 23-243 2.76e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 52.36  E-value: 2.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  23 SLLFVPDEIyRYRGSLEELLLDANQ-------LRDLPKPFFNLTKLRKLGLSDNEIQR-LPGDIANFNQ---LVELDISR 91
Cdd:cd00116  39 AAKALASAL-RPQPSLKELCLSLNEtgriprgLQSLLQGLTKGCGLQELDLSDNALGPdGCGVLESLLRsssLQELKLNN 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  92 NDIMELPESISYC---------KTLQVAD--FSGNPLTRLPESFPELRNLACLSI--NDIS-------LQALPDNignlC 151
Cdd:cd00116 118 NGLGDRGLRLLAKglkdlppalEKLVLGRnrLEGASCEALAKALRANRDLKELNLanNGIGdagiralAEGLKAN----C 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 152 NLVSLELRENLLT-----YLPESLSQLQKLEELDVGSNELYN------LPETIGCLVSLKDLWLDGNQLSDIPAE----- 215
Cdd:cd00116 194 NLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDITDDGAKdlaev 273

                       250       260
                ....*....|....*....|....*....
gi 61806462 216 VGSMRSLTCLDVSENKL-ERLPEEMGNLL 243
Cdd:cd00116 274 LAEKESLLELDLRGNKFgEEGAQLLAESL 302
PLN03150 PLN03150
hypothetical protein; Provisional
 143-217 7.62e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 7.62e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61806462  143 LPDNIGNLCNLVSLELRENLLT-YLPESLSQLQKLEELDVGSNELYNL-PETIGCLVSLKDLWLDGNQLS-DIPAEVG 217
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSiPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 59-320 1.37e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 51.41  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462    59 TKLRKLGLSD-NEIQRLPGDIANFNQLVELDISRNDIME-LPESISYcKTLQVADFSGnpLTRLpESFPELR-NLACLSI 135
Cdd:PLN03210  657 TNLETLKLSDcSSLVELPSSIQYLNKLEDLDMSRCENLEiLPTGINL-KSLYRLNLSG--CSRL-KSFPDIStNISWLDL 732

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   136 NDISLQALPDNIgNLCNLVSLEL----------RENLLTYL----------------------PESLSQLQKLEELDVGS 183
Cdd:PLN03210  733 DETAIEEFPSNL-RLENLDELILcemkseklweRVQPLTPLmtmlspsltrlflsdipslvelPSSIQNLHKLEHLEIEN 811

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   184 -NELYNLPETIGcLVSLKDLWLDG-NQLSDIPAEVGSMRSLTcldVSENKLERLPE--EMGNLLSLTDLLVSQNLIDLLP 259
Cdd:PLN03210  812 cINLETLPTGIN-LESLESLDLSGcSRLRTFPDISTNISDLN---LSRTGIEEVPWwiEKFSNLSFLDMNGCNNLQRVSL 887

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61806462   260 EgIGKLKRLSilKADQNRLVQLPESIGHCESLTELVLTENQLVNLPRSIgKLKKLSNFNCD 320
Cdd:PLN03210  888 N-ISKLKHLE--TVDFSDCGALTEASWNGSPSEVAMATDNIHSKLPSTV-CINFINCFNLD 944
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 38-167 2.09e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 2.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  38 LEELLLDANQLRDLPkPFFNLTKLRKLGLSDNEIQRLPGdIANFNQLVELDISRNDI---MEL---PESISY-CKTLQVA 110
Cdd:cd21340  48 LTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVVEG-LENLTNLEELHIENQRLppgEKLtfdPRSLAAlSNSLRVL 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 111 DFSGNPLTRLpESFPELRNLACLSI--NDIS-LQALPDNIGNLCNLVSLELRENLLTYLP 167
Cdd:cd21340 126 NISGNNIDSL-EPLAPLRNLEQLDAsnNQISdLEELLDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 127-306 3.42e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 127 LRNLACLSINDISLQALpDNIGNLCNLVSLELRENLLTYLpESLSQLQKLEELDVGSNELYNLpETIGCLVSLKDLWLDG 206
Cdd:cd21340   1 LKRITHLYLNDKNITKI-DNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 207 NQLSDIpAEVGSMRSLTCLDVS------ENKLERLPEEMGNLL-SLTDLLVSQNLIDLLpEGIGKLKRLSILKADQNRL- 278
Cdd:cd21340  78 NRISVV-EGLENLTNLEELHIEnqrlppGEKLTFDPRSLAALSnSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIs 155

                       170       180       190
                ....*....|....*....|....*....|
gi 61806462 279 --VQLPESIGHCESLTELVLTENQLVNLPR 306
Cdd:cd21340 156 dlEELLDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
37-94 1.17e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462    37 SLEELLLDANQLRDL-PKPFFNLTKLRKLGLSDNEIQRL-PGDIANFNQLVELDISRNDI 94
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 160-243 1.35e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  160 ENLLTYLPESLSQLQKLEELDVGSNELY-NLPETIGCLVSLKDLWLDGNQLS-DIPAEVGSMRSLTCLDVSENKLE-RLP 236
Cdd:PLN03150 428 QGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVP 507


                 ....*..
gi 61806462  237 EEMGNLL 243
Cdd:PLN03150 508 AALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 189-263 3.93e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 46.35  E-value: 3.93e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61806462  189 LPETIGCLVSLKDLWLDGNQL-SDIPAEVGSMRSLTCLDVSENKLE-RLPEEMGNLLSLTDLLVSQN-LIDLLPEGIG 263
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNsLSGRVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 64-148 1.26e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   64 LGLsDNEIQR--LPGDIANFNQLVELDISRNDIM-ELPESISYCKTLQVADFSGNPLT-RLPESFPELRNLACLSINDIS 139
Cdd:PLN03150 423 LGL-DNQGLRgfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNS 501

                         90
                 ....*....|
gi 61806462  140 LQA-LPDNIG 148
Cdd:PLN03150 502 LSGrVPAALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 304-370 1.37e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 1.37e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61806462  304 LPRSIGKLKKLSNFNCDRNRL-ASLPKEIGGCCSLNVLCVRENRLM-RIPPELSQASELHVLDLSGNRL 370
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-121 1.97e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  37 SLEELLLDANQLRDLPKPFFN-------LTKLRKLGLSDNEIQRLpGDIANFNQLVELDISRN---DIMELPESISYCKT 106
Cdd:cd21340  91 NLEELHIENQRLPPGEKLTFDprslaalSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPS 169

                        90
                ....*....|....*
gi 61806462 107 LQVADFSGNPLTRLP 121
Cdd:cd21340 170 LRELDLTGNPVCKKP 184
PLN03150 PLN03150
hypothetical protein; Provisional
 249-333 3.14e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 3.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  249 LVSQNLIDLLPEGIGKLKRLSILKADQNRLV-QLPESIGHCESLTELVLTENQLVNL-PRSIGKLKKLSNFNCDRNRLAS 326
Cdd:PLN03150 425 LDNQGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSiPESLGQLTSLRILNLNGNSLSG 504


                 ....*...
gi 61806462  327 -LPKEIGG 333
Cdd:PLN03150 505 rVPAALGG 512
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-186 7.19e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 7.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462  37 SLEELLLDANQL-----RDLPKPFFNLTKLRKLGLSDNE-----IQRLPGDIANFNQLVELDISRNDIME-----LPESI 101
Cdd:cd00116 138 ALEKLVLGRNRLegascEALAKALRANRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTDegasaLAETL 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462 102 SYCKTLQVADFSGNPLTR---------LPESFPELR--NLACLSINDISLQALPDNIGNLCNLVSLELRENLLTYLPESL 170
Cdd:cd00116 218 ASLKSLEVLNLGDNNLTDagaaalasaLLSPNISLLtlSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQL 297

                       170       180
                ....*....|....*....|..
gi 61806462 171 SQL------QKLEELDVGSNEL 186
Cdd:cd00116 298 LAEsllepgNELESLWVKDDSF 319
LRR_8 pfam13855
Leucine rich repeat;
152-209 1.29e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   152 NLVSLELRENLLTYL-PESLSQLQKLEELDVGSNELYNL-PETIGCLVSLKDLWLDGNQL 209
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
18-118 1.32e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61806462   18 DRRHCSLLFVPDEIYRY-------------RGSLEELLLDANQLRDLPK-PffnlTKLRKLGLSDNEIQRLPGDIANfnq 83
Cdd:PRK15387 351 DNQLASLPTLPSELYKLwaynnrltslpalPSGLKELIVSGNRLTSLPVlP----SELKELMVSGNRLTSLPMLPSG--- 423

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 61806462   84 LVELDISRNDIMELPESISYCKTLQVADFSGNPLT 118
Cdd:PRK15387 424 LLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLS 458
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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