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Conserved domains on  [gi|6225207|sp|Q9Z0H6|]
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RecName: Full=Cystatin-9; AltName: Full=Testatin; Flags: Precursor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 1.37e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 54.36  E-value: 1.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6225207      43 PTVEFAVNTFNQESQDEYAYRMEHIMSSWReKVNFPTVYSMRLQLRRTICKKFEESLDICPFQESHGLNntftCLFTVGT 122
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSAKS-QVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWE 92

                           90
                   ....*....|....
gi 6225207     123 YPWITKFKLFRSVC 136
Cdd:smart00043  93 KPWENKIKLVEFKC 106
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 1.37e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 54.36  E-value: 1.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6225207      43 PTVEFAVNTFNQESQDEYAYRMEHIMSSWReKVNFPTVYSMRLQLRRTICKKFEESLDICPFQESHGLNntftCLFTVGT 122
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSAKS-QVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWE 92

                           90
                   ....*....|....
gi 6225207     123 YPWITKFKLFRSVC 136
Cdd:smart00043  93 KPWENKIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 9.82e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 44.39  E-value: 9.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6225207   43 PTVEFAVNTFNQESQDEYaYRMEHIMSSwREKVNFPTVYSMRLQLRRTICKKFEESLDiCPFQESHGLNNTFTCLFTVGT 122
Cdd:cd00042  15 ELADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLEEGKKKFCTAKVWE 91

                        90
                ....*....|....
gi 6225207  123 YPWITKFKLFRSVC 136
Cdd:cd00042  92 KPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 36-125 2.02e-05

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.40  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6225207     36 NRSVHFIPTVEFAVNTFNQESQDEYaYRMEHIMSSWREKVNfPTVYSMRLQLRRTICKKFEESLDICPFQEshgLNNTFT 115
Cdd:pfam00031   8 DNSPELQEALDFALAEYNAKTDNYY-FELVEVKRAKSQVVA-GTNYFIKVEVGETDCSKSKKLLEDCPLLD---EKWLGL 82

                          90
                  ....*....|
gi 6225207    116 CLFTVGTYPW 125
Cdd:pfam00031  83 CSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 1.37e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 54.36  E-value: 1.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6225207      43 PTVEFAVNTFNQESQDEYAYRMEHIMSSWReKVNFPTVYSMRLQLRRTICKKFEESLDICPFQESHGLNntftCLFTVGT 122
Cdd:smart00043  18 EAADFAVAEYNKKSNDKYELRVIKVVSAKS-QVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGEKF----CTAKVWE 92

                           90
                   ....*....|....
gi 6225207     123 YPWITKFKLFRSVC 136
Cdd:smart00043  93 KPWENKIKLVEFKC 106
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 43-136 9.82e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 44.39  E-value: 9.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6225207   43 PTVEFAVNTFNQESQDEYaYRMEHIMSSwREKVNFPTVYSMRLQLRRTICKKFEESLDiCPFQESHGLNNTFTCLFTVGT 122
Cdd:cd00042  15 ELADFAVAEYNKKSNDKY-LEFFKVLSA-KSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLEEGKKKFCTAKVWE 91

                        90
                ....*....|....
gi 6225207  123 YPWITKFKLFRSVC 136
Cdd:cd00042  92 KPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 36-125 2.02e-05

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 40.40  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6225207     36 NRSVHFIPTVEFAVNTFNQESQDEYaYRMEHIMSSWREKVNfPTVYSMRLQLRRTICKKFEESLDICPFQEshgLNNTFT 115
Cdd:pfam00031   8 DNSPELQEALDFALAEYNAKTDNYY-FELVEVKRAKSQVVA-GTNYFIKVEVGETDCSKSKKLLEDCPLLD---EKWLGL 82

                          90
                  ....*....|
gi 6225207    116 CLFTVGTYPW 125
Cdd:pfam00031  83 CSAQVYKVPW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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