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Conserved domains on  [gi|6325035|ref|NP_015103|]
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flavin adenine dinucleotide transporter [Saccharomyces cerevisiae S288C]

Protein Classification

transient receptor potential ion channel family protein( domain architecture ID 10629760)

transient receptor potential (TRP) ion channel family protein similar to Saccharomyces cerevisiae flavin carrier protein 1 that may be responsible for the transport of FAD into the endoplasmic reticulum lumen, where it is required for oxidative protein folding

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TRP pfam06011
Transient receptor potential (TRP) ion channel; This family of proteins are transient receptor ...
166-597 0e+00

Transient receptor potential (TRP) ion channel; This family of proteins are transient receptor potential (TRP) ion channels. They are essential for cellular viability and are involved in cell growth and cell wall synthesis. The genes for these proteins are homologous to polycystic kidney disease related ion channel genes.


:

Pssm-ID: 428720  Cd Length: 424  Bit Score: 591.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    166 VKWVTAVIAGIGLLTSAVLSTFGNSTAASHISANTMSLFLYFQSVAVVAMQHVDsVPPIAAAWSENLAWSMGLIRITFMQ 245
Cdd:pfam06011   1 VKWVTAGIAGLALLASAVLSGLGNSNAAAHVAASVLSLFGYFQSQAMVGMLSVN-YPPIAAAWTQNFAWSMGLIRVGFMQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    246 KIFRWYVEATGGSASLYLTA-TTMSVLTQRGLdylkntsvYKRAENVLYGNSNTLIFRGIKRMGYRMKIENTAIVCTGFT 324
Cdd:pfam06011  80 KIINWYVQATGGTPTLVLTSlSTLSVSVKRSL--------AARDKRGNPVTGSPLVLRGIQRVAYRAGIESTNAFMTGLL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    325 FFVLCGYFLAGFIMACKYSIELCIRCGWMRSDRFYQFRKNWRSVLKGSLLRYIYIGFTQLTILSFWEFTERDSAGVIVIA 404
Cdd:pfam06011 152 FFLIFIAVVVVGILLFKAILELLARFGWMKPDRFLEFRKHWWGILKGTLLRLILIGFPQLTILCLWEFTQRDSAAAVVLA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    405 CLFIVLSCGLMAWAAYRTIFFASKSVEMYNNPAALLYGDEYVLNKYGFFYTMFNAKHYWWNALLTTYILVKALFVGFAQA 484
Cdd:pfam06011 232 VILLALFTGLLGWAAFRIIRIARKSKRLHKNPAYLLYSDKKFLNKYGFLYVQYRATRYWFFVPLLVYIFVKGLFIAFAQG 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    485 SGKTQALAIFIIDLAYFVAIIRYKPYLDRPTNIVNIFICTVTLVNSFLFMFFSNLFNQKYAVSAIMGWVFFIMNAAFSLL 564
Cdd:pfam06011 312 SGKVQVIGLLIIELLYLILLIWLRPYMDKRTNVFNIAISVVNVLNAILLLFFSEEFGQPRIVTTVMGVVFFVINAAFTLV 391
                         410       420       430
                  ....*....|....*....|....*....|...
gi 6325035    565 LLLMILAFTTIILFSKNPDSRFKPAKDDRASFQ 597
Cdd:pfam06011 392 LLILIIVNAIIALFSKNPDRRYRPMKDDRRSFL 424
TRP_N pfam14558
ML-like domain; This domain is distantly similar to pfam02221 and conserves its pattern of ...
26-161 1.34e-62

ML-like domain; This domain is distantly similar to pfam02221 and conserves its pattern of conserved cysteines. This suggests that this domain may be involved in lipid binding.


:

Pssm-ID: 434037  Cd Length: 137  Bit Score: 206.20  E-value: 1.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035     26 LTASSLVTCMENSQLSANSFDVSFSPDDRSLHYDLDMTTQIDSYIYAYVDVYAYGFKIITENFDVCSMGWKQFCPVHPGN 105
Cdd:pfam14558   1 LYTTSLSTCMDNSQFTASYFDVTYTPDNRTVTFNVDGTSSISGNVTADLSVTAYGYQIYNKTFDPCDLNVKGLCPLPPGP 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6325035    106 IQIDSIEYIAQKYVKMIPGIAYQVPDIDAYVRLNIYNN-VSENLACIQVFFSNGKTV 161
Cdd:pfam14558  81 IDASGNQPIPADYVSQIPGIAYTIPDLDATVRVRIYSTgTGTEIACVQATLTNGKTV 137
 
Name Accession Description Interval E-value
TRP pfam06011
Transient receptor potential (TRP) ion channel; This family of proteins are transient receptor ...
166-597 0e+00

Transient receptor potential (TRP) ion channel; This family of proteins are transient receptor potential (TRP) ion channels. They are essential for cellular viability and are involved in cell growth and cell wall synthesis. The genes for these proteins are homologous to polycystic kidney disease related ion channel genes.


Pssm-ID: 428720  Cd Length: 424  Bit Score: 591.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    166 VKWVTAVIAGIGLLTSAVLSTFGNSTAASHISANTMSLFLYFQSVAVVAMQHVDsVPPIAAAWSENLAWSMGLIRITFMQ 245
Cdd:pfam06011   1 VKWVTAGIAGLALLASAVLSGLGNSNAAAHVAASVLSLFGYFQSQAMVGMLSVN-YPPIAAAWTQNFAWSMGLIRVGFMQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    246 KIFRWYVEATGGSASLYLTA-TTMSVLTQRGLdylkntsvYKRAENVLYGNSNTLIFRGIKRMGYRMKIENTAIVCTGFT 324
Cdd:pfam06011  80 KIINWYVQATGGTPTLVLTSlSTLSVSVKRSL--------AARDKRGNPVTGSPLVLRGIQRVAYRAGIESTNAFMTGLL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    325 FFVLCGYFLAGFIMACKYSIELCIRCGWMRSDRFYQFRKNWRSVLKGSLLRYIYIGFTQLTILSFWEFTERDSAGVIVIA 404
Cdd:pfam06011 152 FFLIFIAVVVVGILLFKAILELLARFGWMKPDRFLEFRKHWWGILKGTLLRLILIGFPQLTILCLWEFTQRDSAAAVVLA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    405 CLFIVLSCGLMAWAAYRTIFFASKSVEMYNNPAALLYGDEYVLNKYGFFYTMFNAKHYWWNALLTTYILVKALFVGFAQA 484
Cdd:pfam06011 232 VILLALFTGLLGWAAFRIIRIARKSKRLHKNPAYLLYSDKKFLNKYGFLYVQYRATRYWFFVPLLVYIFVKGLFIAFAQG 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    485 SGKTQALAIFIIDLAYFVAIIRYKPYLDRPTNIVNIFICTVTLVNSFLFMFFSNLFNQKYAVSAIMGWVFFIMNAAFSLL 564
Cdd:pfam06011 312 SGKVQVIGLLIIELLYLILLIWLRPYMDKRTNVFNIAISVVNVLNAILLLFFSEEFGQPRIVTTVMGVVFFVINAAFTLV 391
                         410       420       430
                  ....*....|....*....|....*....|...
gi 6325035    565 LLLMILAFTTIILFSKNPDSRFKPAKDDRASFQ 597
Cdd:pfam06011 392 LLILIIVNAIIALFSKNPDRRYRPMKDDRRSFL 424
TRP_N pfam14558
ML-like domain; This domain is distantly similar to pfam02221 and conserves its pattern of ...
26-161 1.34e-62

ML-like domain; This domain is distantly similar to pfam02221 and conserves its pattern of conserved cysteines. This suggests that this domain may be involved in lipid binding.


Pssm-ID: 434037  Cd Length: 137  Bit Score: 206.20  E-value: 1.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035     26 LTASSLVTCMENSQLSANSFDVSFSPDDRSLHYDLDMTTQIDSYIYAYVDVYAYGFKIITENFDVCSMGWKQFCPVHPGN 105
Cdd:pfam14558   1 LYTTSLSTCMDNSQFTASYFDVTYTPDNRTVTFNVDGTSSISGNVTADLSVTAYGYQIYNKTFDPCDLNVKGLCPLPPGP 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6325035    106 IQIDSIEYIAQKYVKMIPGIAYQVPDIDAYVRLNIYNN-VSENLACIQVFFSNGKTV 161
Cdd:pfam14558  81 IDASGNQPIPADYVSQIPGIAYTIPDLDATVRVRIYSTgTGTEIACVQATLTNGKTV 137
ML cd00912
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, ...
31-155 5.18e-30

The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of unknown function in plants, animals and fungi. These single-domain proteins form two anti-parallel beta-pleated sheets stabilized by three disulfide bonds and with an accessible central hydrophobic cavity, and are predicted to mediate diverse biological functions through interaction with specific lipids.


Pssm-ID: 238454  Cd Length: 127  Bit Score: 114.92  E-value: 5.18e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035   31 LVTCMENSqlsANSFDVSFSPDD-------RSLHYDLDMTTQIDSYIYA-YVDVYAYGFKIITEN----FDVCSMGWK-- 96
Cdd:cd00912   1 LVDCSDNS---ANIKEVLLSPCDplpcpdhRGGNYNLSVTGTLREDIKSlYVDLALMSQGIKVLNpdnsYDFCEAGLPkp 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035   97 QFCPVHPG-NIQIDSIEYIAQkyvKMIPGIAYQVPDIDAYvrlniynNVSENLACIQVFF 155
Cdd:cd00912  78 SFCPLRKGqQYSYAKTVNVPE---FTIPTIEYQVVLEDVT-------DKGEVLACAQATI 127
 
Name Accession Description Interval E-value
TRP pfam06011
Transient receptor potential (TRP) ion channel; This family of proteins are transient receptor ...
166-597 0e+00

Transient receptor potential (TRP) ion channel; This family of proteins are transient receptor potential (TRP) ion channels. They are essential for cellular viability and are involved in cell growth and cell wall synthesis. The genes for these proteins are homologous to polycystic kidney disease related ion channel genes.


Pssm-ID: 428720  Cd Length: 424  Bit Score: 591.04  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    166 VKWVTAVIAGIGLLTSAVLSTFGNSTAASHISANTMSLFLYFQSVAVVAMQHVDsVPPIAAAWSENLAWSMGLIRITFMQ 245
Cdd:pfam06011   1 VKWVTAGIAGLALLASAVLSGLGNSNAAAHVAASVLSLFGYFQSQAMVGMLSVN-YPPIAAAWTQNFAWSMGLIRVGFMQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    246 KIFRWYVEATGGSASLYLTA-TTMSVLTQRGLdylkntsvYKRAENVLYGNSNTLIFRGIKRMGYRMKIENTAIVCTGFT 324
Cdd:pfam06011  80 KIINWYVQATGGTPTLVLTSlSTLSVSVKRSL--------AARDKRGNPVTGSPLVLRGIQRVAYRAGIESTNAFMTGLL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    325 FFVLCGYFLAGFIMACKYSIELCIRCGWMRSDRFYQFRKNWRSVLKGSLLRYIYIGFTQLTILSFWEFTERDSAGVIVIA 404
Cdd:pfam06011 152 FFLIFIAVVVVGILLFKAILELLARFGWMKPDRFLEFRKHWWGILKGTLLRLILIGFPQLTILCLWEFTQRDSAAAVVLA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    405 CLFIVLSCGLMAWAAYRTIFFASKSVEMYNNPAALLYGDEYVLNKYGFFYTMFNAKHYWWNALLTTYILVKALFVGFAQA 484
Cdd:pfam06011 232 VILLALFTGLLGWAAFRIIRIARKSKRLHKNPAYLLYSDKKFLNKYGFLYVQYRATRYWFFVPLLVYIFVKGLFIAFAQG 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035    485 SGKTQALAIFIIDLAYFVAIIRYKPYLDRPTNIVNIFICTVTLVNSFLFMFFSNLFNQKYAVSAIMGWVFFIMNAAFSLL 564
Cdd:pfam06011 312 SGKVQVIGLLIIELLYLILLIWLRPYMDKRTNVFNIAISVVNVLNAILLLFFSEEFGQPRIVTTVMGVVFFVINAAFTLV 391
                         410       420       430
                  ....*....|....*....|....*....|...
gi 6325035    565 LLLMILAFTTIILFSKNPDSRFKPAKDDRASFQ 597
Cdd:pfam06011 392 LLILIIVNAIIALFSKNPDRRYRPMKDDRRSFL 424
TRP_N pfam14558
ML-like domain; This domain is distantly similar to pfam02221 and conserves its pattern of ...
26-161 1.34e-62

ML-like domain; This domain is distantly similar to pfam02221 and conserves its pattern of conserved cysteines. This suggests that this domain may be involved in lipid binding.


Pssm-ID: 434037  Cd Length: 137  Bit Score: 206.20  E-value: 1.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035     26 LTASSLVTCMENSQLSANSFDVSFSPDDRSLHYDLDMTTQIDSYIYAYVDVYAYGFKIITENFDVCSMGWKQFCPVHPGN 105
Cdd:pfam14558   1 LYTTSLSTCMDNSQFTASYFDVTYTPDNRTVTFNVDGTSSISGNVTADLSVTAYGYQIYNKTFDPCDLNVKGLCPLPPGP 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6325035    106 IQIDSIEYIAQKYVKMIPGIAYQVPDIDAYVRLNIYNN-VSENLACIQVFFSNGKTV 161
Cdd:pfam14558  81 IDASGNQPIPADYVSQIPGIAYTIPDLDATVRVRIYSTgTGTEIACVQATLTNGKTV 137
ML cd00912
The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, ...
31-155 5.18e-30

The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of unknown function in plants, animals and fungi. These single-domain proteins form two anti-parallel beta-pleated sheets stabilized by three disulfide bonds and with an accessible central hydrophobic cavity, and are predicted to mediate diverse biological functions through interaction with specific lipids.


Pssm-ID: 238454  Cd Length: 127  Bit Score: 114.92  E-value: 5.18e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035   31 LVTCMENSqlsANSFDVSFSPDD-------RSLHYDLDMTTQIDSYIYA-YVDVYAYGFKIITEN----FDVCSMGWK-- 96
Cdd:cd00912   1 LVDCSDNS---ANIKEVLLSPCDplpcpdhRGGNYNLSVTGTLREDIKSlYVDLALMSQGIKVLNpdnsYDFCEAGLPkp 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035   97 QFCPVHPG-NIQIDSIEYIAQkyvKMIPGIAYQVPDIDAYvrlniynNVSENLACIQVFF 155
Cdd:cd00912  78 SFCPLRKGqQYSYAKTVNVPE---FTIPTIEYQVVLEDVT-------DKGEVLACAQATI 127
PG-PI_TP cd00917
The phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP) has been shown to ...
72-151 5.55e-03

The phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP) has been shown to bind phosphatidylglycerol and phosphatidylinositol, but the biological significance of this is still obscure. These proteins belong to the ML domain family.


Pssm-ID: 238459  Cd Length: 122  Bit Score: 37.69  E-value: 5.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325035   72 AYVDV-YAYG-FKIITENFDVC----SMGWKqfCPVHPGNIQIDSIeyiaQKYVKMIPGIAYqvpdidaYVRLNIYNNVS 145
Cdd:cd00917  46 AYVVVeVKYGfIRLLSETYDLCdetkNVDLS--CPIEPGDKFLTKL----VDLPGEIPPGKY-------TVSARAYTKDD 112

                ....*.
gi 6325035  146 ENLACI 151
Cdd:cd00917 113 EEITCL 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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