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Conserved domains on  [gi|640274]
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Chain B, Phaseolin

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 25-207 1.07e-64

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380371  Cd Length: 178  Bit Score: 204.28  E-value: 1.07e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274    25 LFKNQYGHIRVLQRFDQQSKRLQNLEDYRLVEFRSKPETLLLPQQADAELLLVVRSGSAILVLVKPDDRREYfFLTSdnp 104
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESY-NLER--- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   105 ifSDHQKIPAGTIFYLVNPDPKEDLRIIQLAMPVNNP---QIHEFFLSSTEAQQSYLQEFSKHILEASFNSKFEEINRVL 181
Cdd:cd02244  77 --GDVYRIPAGSTFYLVNTDENEKLRIIALFDPVNSLtpgPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLL 154

                       170       180
                ....*....|....*....|....*.
gi 640274   182 feeEGQQEGVIVNIDSEQIKELSKHA 207
Cdd:cd02244 155 ---SQQKPGPIVKASEEQIRALSRHA 177
cupin_7S_11S_C cd20285
7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal ...
 227-323 7.87e-39

7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal cupin domains of 7S and 11S seed storage proteins. The 7S globulins include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The 11S globulins include many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


:

Pssm-ID: 380420  Cd Length: 109  Bit Score: 135.04  E-value: 7.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   227 GNLTERTDN------SLNVLISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGnketleYESYRAELSKDDVF 300
Cdd:cd20285   1 GNVTERTSNdfpilkSLNLLASSISLEEGAMFVPHYYSKAIVILVVNEGRAHIQVVGPKG------YESYDAELSKGDVF 74

                        90       100
                ....*....|....*....|....
gi 640274   301 VIPAAYPVAIKATS-NVNFTGFGI 323
Cdd:cd20285  75 VVPAAFPVAIKSTShNVEFTGFGT 98
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 25-207 1.07e-64

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 204.28  E-value: 1.07e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274    25 LFKNQYGHIRVLQRFDQQSKRLQNLEDYRLVEFRSKPETLLLPQQADAELLLVVRSGSAILVLVKPDDRREYfFLTSdnp 104
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESY-NLER--- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   105 ifSDHQKIPAGTIFYLVNPDPKEDLRIIQLAMPVNNP---QIHEFFLSSTEAQQSYLQEFSKHILEASFNSKFEEINRVL 181
Cdd:cd02244  77 --GDVYRIPAGSTFYLVNTDENEKLRIIALFDPVNSLtpgPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLL 154

                       170       180
                ....*....|....*....|....*.
gi 640274   182 feeEGQQEGVIVNIDSEQIKELSKHA 207
Cdd:cd02244 155 ---SQQKPGPIVKASEEQIRALSRHA 177
cupin_7S_11S_C cd20285
7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal ...
 227-323 7.87e-39

7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal cupin domains of 7S and 11S seed storage proteins. The 7S globulins include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The 11S globulins include many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380420  Cd Length: 109  Bit Score: 135.04  E-value: 7.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   227 GNLTERTDN------SLNVLISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGnketleYESYRAELSKDDVF 300
Cdd:cd20285   1 GNVTERTSNdfpilkSLNLLASSISLEEGAMFVPHYYSKAIVILVVNEGRAHIQVVGPKG------YESYDAELSKGDVF 74

                        90       100
                ....*....|....*....|....
gi 640274   301 VIPAAYPVAIKATS-NVNFTGFGI 323
Cdd:cd20285  75 VVPAAFPVAIKSTShNVEFTGFGT 98
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 218-366 4.41e-21

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 88.49  E-value: 4.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274      218 QDNTIGNEFGNLTERTDNSLNVLISS------IEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGNKEtleyesYR 291
Cdd:smart00835   3 PRPDFSNEGGRLREADPTNFPALNGLgisaarVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGNKV------YD 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640274      292 AELSKDDVFVIPAAYPVAIKATSNVNFTGFGINANNNNRNLLAGKTDNVISSIGRaldgkDVLGLTFSGSGDEVM 366
Cdd:smart00835  77 ARLREGDVFVVPQGHPHFQVNSGDENLEFVAFNTNDPNRRFFLAGRNSVLRGLPP-----EVLAAAFGVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 218-365 1.28e-14

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 70.83  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274     218 QDNTIGNEFGNLTERTDNSLNVL------ISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGnketlEYESYR 291
Cdd:pfam00190   6 PGPTYNPEGGRVTTVNSKNLPGLntlgisAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPGN-----GNRVFH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 640274     292 AELSKDDVFVIPAAYPVAIKA---TSNVNFTGFGINANNNNrnllagKTDNVISSIGRALDgKDVLGLTFSGSGDEV 365
Cdd:pfam00190  81 KVLREGDVFVVPQGLPHFQYNigdEPAVAFVAFDTNNPGNQ------SILAGGFSSLPALP-PEVLAKAFQLAGEEV 150
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 26-177 1.78e-05

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 44.19  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274       26 FKNQYGHIRVLqrFDQQSKRLQNLeDYRLVEFRSKPETLLLPQ-QADAELLLVVRSGSAILVLVKPDDRREYFFLTSDNP 104
Cdd:smart00835   7 FSNEGGRLREA--DPTNFPALNGL-GISAARVNLEPGGMLPPHyHPRATELLYVVRGEGRVGVVDPNGNKVYDARLREGD 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640274      105 IFSdhqkIPAGTIFYLVNPDpKEDLRIiqLAMPVNNPQiHEFFLSsteAQQSYLQEFSKHILEASFNSKFEEI 177
Cdd:smart00835  84 VFV----VPQGHPHFQVNSG-DENLEF--VAFNTNDPN-RRFFLA---GRNSVLRGLPPEVLAAAFGVSAEEV 145
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 244-315 5.87e-03

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 36.48  E-value: 5.87e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640274   244 IEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGNKETleyesyrAELSKDDVFVIPAAYPVAIKATSN 315
Cdd:COG2140   8 TVLEPGGVREEHWHPNAAEWYYVLSGEARMTVQDPPGRART-------VDVGPGDVVYVPPGYGHYIINTGD 72
 
Name Accession Description Interval E-value
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 25-207 1.07e-64

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 204.28  E-value: 1.07e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274    25 LFKNQYGHIRVLQRFDQQSKRLQNLEDYRLVEFRSKPETLLLPQQADAELLLVVRSGSAILVLVKPDDRREYfFLTSdnp 104
Cdd:cd02244   1 VVRTEAGEIRVLERFDGRSRLLRGIENYRLAFITMEPNTLFLPHHLDADMVFYVHTGRGTITWVDEDKRESY-NLER--- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   105 ifSDHQKIPAGTIFYLVNPDPKEDLRIIQLAMPVNNP---QIHEFFLSSTEAQQSYLQEFSKHILEASFNSKFEEINRVL 181
Cdd:cd02244  77 --GDVYRIPAGSTFYLVNTDENEKLRIIALFDPVNSLtpgPFQSFFGAGGQNPESLLSGFSKEILEAAFNVSEEELERLL 154

                       170       180
                ....*....|....*....|....*.
gi 640274   182 feeEGQQEGVIVNIDSEQIKELSKHA 207
Cdd:cd02244 155 ---SQQKPGPIVKASEEQIRALSRHA 177
cupin_7S_11S_C cd20285
7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal ...
 227-323 7.87e-39

7S and 11S seed storage globulin, C-terminal cupin domain; This family contains the C-terminal cupin domains of 7S and 11S seed storage proteins. The 7S globulins include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The 11S globulins include many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380420  Cd Length: 109  Bit Score: 135.04  E-value: 7.87e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   227 GNLTERTDN------SLNVLISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGnketleYESYRAELSKDDVF 300
Cdd:cd20285   1 GNVTERTSNdfpilkSLNLLASSISLEEGAMFVPHYYSKAIVILVVNEGRAHIQVVGPKG------YESYDAELSKGDVF 74

                        90       100
                ....*....|....*....|....
gi 640274   301 VIPAAYPVAIKATS-NVNFTGFGI 323
Cdd:cd20285  75 VVPAAFPVAIKSTShNVEFTGFGT 98
cupin_7S_vicilin-like_C cd02245
7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal ...
 221-375 2.99e-37

7S vicilin seed storage globulin, C-terminal cupin domain; This family contains C-terminal domain of plant 7S seed storage protein such as vicilin and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2 and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380372  Cd Length: 166  Bit Score: 132.64  E-value: 2.99e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   221 TIGNEFGNLTERTDN------SLNVLISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGN--------KETLE 286
Cdd:cd02245   2 DFSNQYGWLYEADPEdykqlkDLDVGVSFVNITQGSMMAPHYNSRATEIAVVVEGEGYVEMVCPHLSsqsqqgeeEGSGE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   287 YESYRAELSKDDVFVIPAAYPVAIKATSNVN--FTGFGINANNNNRNLLAGKtDNVISSIGRaldgkDVLGLTFSGSGDE 364
Cdd:cd02245  82 YQKVRARLSEGDVFVVPAGHPVAQVASSNENleFVGFGINAQNNERQFLAGK-NNVLRQLDR-----EAKELAFNVPAEE 155

                       170
                ....*....|.
gi 640274   365 VMKLINKQSGS 375
Cdd:cd02245 156 VEEVLNAQDES 166
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 218-366 4.41e-21

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 88.49  E-value: 4.41e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274      218 QDNTIGNEFGNLTERTDNSLNVLISS------IEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGNKEtleyesYR 291
Cdd:smart00835   3 PRPDFSNEGGRLREADPTNFPALNGLgisaarVNLEPGGMLPPHYHPRATELLYVVRGEGRVGVVDPNGNKV------YD 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640274      292 AELSKDDVFVIPAAYPVAIKATSNVNFTGFGINANNNNRNLLAGKTDNVISSIGRaldgkDVLGLTFSGSGDEVM 366
Cdd:smart00835  77 ARLREGDVFVVPQGHPHFQVNSGDENLEFVAFNTNDPNRRFFLAGRNSVLRGLPP-----EVLAAAFGVSAEEVR 146
Cupin_1 pfam00190
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 218-365 1.28e-14

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 395138  Cd Length: 151  Bit Score: 70.83  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274     218 QDNTIGNEFGNLTERTDNSLNVL------ISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGnketlEYESYR 291
Cdd:pfam00190   6 PGPTYNPEGGRVTTVNSKNLPGLntlgisAARVDLAPGGMNPPHWHPNATEILYVLQGRGRVGFVVPGN-----GNRVFH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 640274     292 AELSKDDVFVIPAAYPVAIKA---TSNVNFTGFGINANNNNrnllagKTDNVISSIGRALDgKDVLGLTFSGSGDEV 365
Cdd:pfam00190  81 KVLREGDVFVVPQGLPHFQYNigdEPAVAFVAFDTNNPGNQ------SILAGGFSSLPALP-PEVLAKAFQLAGEEV 150
cupin_11S_legumin_C cd02243
11S legumin seed storage globulin, C-terminal cupin domain; This family contains the ...
 246-315 5.51e-08

11S legumin seed storage globulin, C-terminal cupin domain; This family contains the C-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380370  Cd Length: 155  Bit Score: 51.71  E-value: 5.51e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   246 MEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGNKetleyeSYRAELSKDDVFVIPAAYPVAIKATSN 315
Cdd:cd02243  33 LEPNAMFAPHWNANAHQVIYVTRGSGRVQVVGDNGKR------VLDGEVREGQLLVVPQFFAVAKIAGEE 96
Cupin_1 smart00835
Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' ...
 26-177 1.78e-05

Cupin; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.


Pssm-ID: 214845 [Multi-domain]  Cd Length: 146  Bit Score: 44.19  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274       26 FKNQYGHIRVLqrFDQQSKRLQNLeDYRLVEFRSKPETLLLPQ-QADAELLLVVRSGSAILVLVKPDDRREYFFLTSDNP 104
Cdd:smart00835   7 FSNEGGRLREA--DPTNFPALNGL-GISAARVNLEPGGMLPPHyHPRATELLYVVRGEGRVGVVDPNGNKVYDARLREGD 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640274      105 IFSdhqkIPAGTIFYLVNPDpKEDLRIiqLAMPVNNPQiHEFFLSsteAQQSYLQEFSKHILEASFNSKFEEI 177
Cdd:smart00835  84 VFV----VPQGHPHFQVNSG-DENLEF--VAFNTNDPN-RRFFLA---GRNSVLRGLPPEVLAAAFGVSAEEV 145
cupin_OxDC-like cd20306
Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and ...
 224-314 5.00e-04

Oxalate decarboxylase (OxDC)-like cupin domain; This subfamily contains bacterial and eukaryotic cupin domains of proteins homologous to oxalate decarboxylase (OxDC; EC 4.1.1.2) such as MSMEG_2254, a putative OxDC from Mycobacterium smegmatis. OxDC is a manganese-dependent bicupin that catalyzes the conversion of oxalate to formate and carbon dioxide, utilizing dioxygen as a cofactor. It is evolutionarily related to oxalate oxidase (OxOx or germin; EC 1.2.3.4) which, in contrast, converts oxalate and dioxygen to carbon dioxide and hydrogen peroxide. OxDC is classified as a bicupin because it contains two cupin folds with each domain containing one manganese binding site, with four manganese binding residues (three histidines and one glutamate) conserved as well as a number of hydrophobic residues.


Pssm-ID: 380440 [Multi-domain]  Cd Length: 151  Bit Score: 40.27  E-value: 5.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   224 NEFGNLTERTDNSLNVL----ISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGNKETLeyesyraELSKDDV 299
Cdd:cd20306  15 SEGGSIRQATADQLPVLkglsIYRLRLSPGGIREPHWHPNANELGYVISGEARVSILDPTGSLDTF-------TVKPGQV 87

                        90
                ....*....|....*
gi 640274   300 FVIPAAYPVAIKATS 314
Cdd:cd20306  88 VFIPQGWLHWIENVG 102
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 241-315 8.83e-04

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 37.85  E-value: 8.83e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640274   241 ISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGpkgnketleyeSYRAELSKDDVFVIPAAYPVAIKATSN 315
Cdd:cd02208   1 ISVVTLPPGTSSPPHWHPEQDEIFYVLSGEGELTLDD-----------GETVELKAGDIVLIPPGVPHSFVNTSD 64
cupin_7S_vicilin-like_N cd02244
7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal ...
 241-304 1.06e-03

7S vicilin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of plant 7S seed storage proteins such as vicilin, and includes beta-conglycinin, phaseolin, canavalin, conglutin-beta, a chromatin protein in Pisum sativum called P54, and a sucrose binding protein in soybean called SBP. These 7S globulins also include soybean allergen beta-conglycinin, peanut allergen conarachin (Ara h 1), walnut allergen Jug r 2, and lentil allergen Len c 1. Proteins in this family perform various functions, including a role in sucrose binding, desiccation, defense against microbes and oxidative stress. The vicilin peptides formed by trypsin or chymotrypsin digestion exhibit antihypertensive effects. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). Storage proteins are the cause of well-known allergic reactions to peanuts and cereals. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380371  Cd Length: 178  Bit Score: 39.80  E-value: 1.06e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640274   241 ISSIEMEEGALFVPHYYsKAIVILVVNEGEAHVELVGPKgnketlEYESYRaeLSKDDVFVIPA 304
Cdd:cd02244  30 LAFITMEPNTLFLPHHL-DADMVFYVHTGRGTITWVDED------KRESYN--LERGDVYRIPA 84
cupin_OxOx cd02241
Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3. ...
 235-303 2.33e-03

Oxalate oxidase (germin), cupin domain; Oxalate oxidase (OxOx, also known as germin; EC 1.2.3.4) catalyzes the manganese-dependent oxidative decarboxylation of oxalate to carbon dioxide and hydrogen peroxide (H2O2). It is widespread in fungi and various plant tissues and may play a role in plant signaling and defense. This enzyme has been employed in a widely used assay for detecting urinary oxalate levels. Also, the gene encoding OxOx from barley roots has been expressed in oilseed rape in order to provide a defense against externally supplied oxalic acid. In germin, the predominant protein produced during the early phase of wheat germination, it is believed that H2O2 production is employed as a defense mechanism in response to infection by pathogens. Germin is also a marker of growth onset in cell walls in germinating cereals. The H2O2 produced by OxOx, together with the Ca2+ released by degradation of calcium oxalate, are thought to mediate cell wall cross-linking at high concentrations. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380368  Cd Length: 191  Bit Score: 38.73  E-value: 2.33e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640274   235 NSLNVLISSIEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGNKEtleyesYRAELSKDDVFVIP 303
Cdd:cd02241  66 NGLGISMARGDLAPCGVNPPHTHPRATELLYVVEGTLYVGFVDENGNRL------FTKTLNPGDVFVFP 128
cupin_11S_legumin_N cd02242
11S legumin seed storage globulin, N-terminal cupin domain; This family contains the ...
 60-196 3.00e-03

11S legumin seed storage globulin, N-terminal cupin domain; This family contains the N-terminal domains of 11S legumin seed storage proteins that supply nutrition for seed germination, such as glycinin and legumin, including many common food allergens such as the peanut major allergen Ara h 3, almond allergen Pru du 6, Pecan allergen Car i 4, hazelnut nut allergen Cor a 9, Brazil nut allergen Ber e 2, cashew allergen Ana o 2, pistachio allergen Pis v 2/5, and walnut allergen Jug n/r 4. These plant seed storage globulins have tandem cupin-like beta-barrel folds (referred to as a bicupin). They are synthesized as propeptides in the endoplasmic reticulum and transported to the secretory vesicles as a homotrimer. The propeptides are processed as they are sorted in the secretory vesicles. The homotrimer binds another homotrimer to form a homohexamer with 32-point symmetry formed by a face-to-face stacking of the two trimers. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380369  Cd Length: 209  Bit Score: 38.72  E-value: 3.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274    60 KPETLLLPQQADAELLLVVRSGSAILVLVKPDDRREY---FFLTSDNPIFSD-HQKI-----------PAGTIFYLVNpD 124
Cdd:cd02242  43 EPRGLLLPSYSNAPKLAYVLQGRGIVGVVFPGCPETFqssQQSQGQGQRFRDqHQKVrrirkgdviavPAGVVHWWYN-D 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640274   125 PKEDLRIIQLAmPVNNPQIH------EFFLSSTEAQQSYLQE------------FSKHILEASFNSKFEEINRVLfeEEG 186
Cdd:cd02242 122 GDSDLVIVFLG-DTSNNANQldgnfrRFFLAGNPQQEQQGQGqeqsgggnifsgFSTEFLAEAFGVDEETARKLQ--GSQ 198

                       170
                ....*....|
gi 640274   187 QQEGVIVNID 196
Cdd:cd02242 199 DQRGLIVKVE 208
OxdD COG2140
Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate ...
 244-315 5.87e-03

Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily [Carbohydrate transport and metabolism]; Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 441743 [Multi-domain]  Cd Length: 115  Bit Score: 36.48  E-value: 5.87e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 640274   244 IEMEEGALFVPHYYSKAIVILVVNEGEAHVELVGPKGNKETleyesyrAELSKDDVFVIPAAYPVAIKATSN 315
Cdd:COG2140   8 TVLEPGGVREEHWHPNAAEWYYVLSGEARMTVQDPPGRART-------VDVGPGDVVYVPPGYGHYIINTGD 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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