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Conserved domains on  [gi|658864739|ref|XP_008415208|]
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PREDICTED: alpha-2,8-sialyltransferase 8F-like [Poecilia reticulata]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 79-352 5.50e-164

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467699  Cd Length: 271  Bit Score: 459.03  E-value: 5.50e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  79 ERFQKFRSQLSTKCHGVEKATITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSS 158
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 159 CGKMIDSAEFVIRCNLPPLSNgyEKHVGIKTDLVTANPSILLEKFGALMGRRRKFVESLHSYGNSLLLLPAFSYGHNTPV 238
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 239 SLRAFYTLEDFESPVQPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNH 318
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHH 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 658864739 319 YYDDRKTKTKFHAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23971  238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 79-352 5.50e-164

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 459.03  E-value: 5.50e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  79 ERFQKFRSQLSTKCHGVEKATITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSS 158
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 159 CGKMIDSAEFVIRCNLPPLSNgyEKHVGIKTDLVTANPSILLEKFGALMGRRRKFVESLHSYGNSLLLLPAFSYGHNTPV 238
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 239 SLRAFYTLEDFESPVQPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNH 318
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHH 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 658864739 319 YYDDRKTKTKFHAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23971  238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 99-347 2.40e-104

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 307.23  E-value: 2.40e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739   99 TITQANTPVGSKLVYdGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLs 178
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  179 NGYEKHVGIKTDLVTANP-SILLEKFGALMGR--RRKFVESLHSY--GNSLLLLPAFSYGHNTPVSLRAFYTLEDFESPV 253
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  254 ---QPIFFNPGYLHNLALFW-RSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfhpySFQTLTNHYYDDRKTK--- 326
Cdd:pfam00777 159 dpdKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFL----DSRGNSHHYYDNVLMKkgg 234

                         250       260
                  ....*....|....*....|..
gi 658864739  327 -TKFHAMPDEFSHLLRLHSQGV 347
Cdd:pfam00777 235 fYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 79-352 5.50e-164

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 459.03  E-value: 5.50e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  79 ERFQKFRSQLSTKCHGVEKATITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSS 158
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 159 CGKMIDSAEFVIRCNLPPLSNgyEKHVGIKTDLVTANPSILLEKFGALMGRRRKFVESLHSYGNSLLLLPAFSYGHNTPV 238
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLND--SKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 239 SLRAFYTLEDFESPVQPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNH 318
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISHH 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 658864739 319 YYDDRKTKTKFHAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23971  238 YYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 79-352 6.96e-117

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 339.81  E-value: 6.96e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  79 ERFQKFRSQLSTKCHGVEKATITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSS 158
Cdd:cd23991    1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 159 CGKMIDSAEFVIRCNLPPLSNGYEKHVGIKTDLVTANPSILLEKFGALMGRRRKFVESLHSYGNSLLLLPAFSYGHNTPV 238
Cdd:cd23991   81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 239 SLRAFYTLEDFESPVQPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfHPYSFQTLTNH 318
Cdd:cd23991  161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFS-KNTEGKPISHH 239

                        250       260       270
                 ....*....|....*....|....*....|....
gi 658864739 319 YYDDRKTKTKFHAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23991  240 YYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 99-347 2.40e-104

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 307.23  E-value: 2.40e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739   99 TITQANTPVGSKLVYdGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLs 178
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  179 NGYEKHVGIKTDLVTANP-SILLEKFGALMGR--RRKFVESLHSY--GNSLLLLPAFSYGHNTPVSLRAFYTLEDFESPV 253
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  254 ---QPIFFNPGYLHNLALFW-RSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfhpySFQTLTNHYYDDRKTK--- 326
Cdd:pfam00777 159 dpdKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFL----DSRGNSHHYYDNVLMKkgg 234

                         250       260
                  ....*....|....*....|..
gi 658864739  327 -TKFHAMPDEFSHLLRLHSQGV 347
Cdd:pfam00777 235 fYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 80-352 1.37e-99

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 295.71  E-value: 1.37e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  80 RFQKFRSQLSTKCHgVEKATITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSC 159
Cdd:cd23963    2 ALDKFRKELERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 160 GKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDLVTANPSILLEKFGALMGR--RRKFVESLHSYGNSLLLLPAFSYGHNTP 237
Cdd:cd23963   81 GKEIDSHDFVIRCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKKNrdRDKFLNRLKEYNGSILWYPKFSFKSSTN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 238 VSLRAFYTLEDFESPVQPIFFNPGYLHNLALFWRSQGLRTiRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfQTLTN 317
Cdd:cd23963  160 LLLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLEK-RPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNG-RPVPY 237

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 658864739 318 HYYDDRKTKT--KFHAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23963  238 HYYDDLSPSTknKVHNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 84-351 1.24e-97

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 290.97  E-value: 1.24e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  84 FRSQLSTKCHGVEKATITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMI 163
Cdd:cd23990    6 FKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 164 DSAEFVIRCNLPPLSNGYEKHVGIKTDLVTANPSILLEKFGALMGRRRKFVESLHSYGNSLLLLPAFSYGHNTPVSLRAF 243
Cdd:cd23990   86 DSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRVK 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 244 YTLEDFESPVQPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPySFQTLTNHYYDDR 323
Cdd:cd23990  166 YVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNP-SGIFITHHYYDNV 244

                        250       260
                 ....*....|....*....|....*...
gi 658864739 324 KTKTKFHAMPDEFSHLLRLHSQGVLKLH 351
Cdd:cd23990  245 KPRPGFHAMPSEIFNFLHMHSRGILRVH 272
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 84-352 4.06e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 284.42  E-value: 4.06e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  84 FRSQLSTKCHGVEKATITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPnKTWHTCAVVGNGGILANSSCGKMI 163
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 164 DSAEFVIRCNLPPLSNGYEKHVGIKTDLVTANPSILLEKFGALMGRRRKFVESLHSYGNSLLLLPAFSYGHNTPVSLRAF 243
Cdd:cd23989   85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 244 YTLEDFESPVQPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfQTLTNHYYDDR 323
Cdd:cd23989  165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDE-RTISHHYYDNV 243

                        250       260
                 ....*....|....*....|....*....
gi 658864739 324 KTKTKFHAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23989  244 LPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 99-352 9.08e-70

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 219.96  E-value: 9.08e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  99 TITQANTPVGSKLVYD-GEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPL 177
Cdd:cd23970   24 SLTKKDVRIGQLMHFDySSHKYVFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 178 SnGYEKHVGIKTDLVTANPSILLEKFGALMGR--RRKFVESLHSYGNSLLLLPAFSYGHNTPVslraFYTLEDF------ 249
Cdd:cd23970  104 E-GFEKDVGRKTNLTTFNPSILEKYYNNLLTIqdRNNFFLSLKKLDGAILWIPAFFFHTSATV----TRTLVDFfvehrg 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 250 ESPVQPIFfnPG-YLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfQTLTNHYYDDRKTK-- 326
Cdd:cd23970  179 QLKVQLAW--PGnIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTG-TPLPYHYYDKKGTKft 255

                        250       260
                 ....*....|....*....|....*....
gi 658864739 327 ---TKFHAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23970  256 tkwQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 99-351 1.11e-66

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 211.89  E-value: 1.11e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  99 TITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLS 178
Cdd:cd23969   21 SVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 179 nGYEKHVGIKTDLVTANPSILLEKFGALMGR--RRKFVESLHSYGNSLLLLPAFSyghNTPVSLRAFYTLE---DFESPV 253
Cdd:cd23969  101 -GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFV---SKGGEEHVQWTNEiilKHKLNV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 254 QPIFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfQTLTNHYYDDRK--TKTKFHA 331
Cdd:cd23969  177 KTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNG-RAVKYHYYDNRKylTTARPHK 255

                        250       260
                 ....*....|....*....|
gi 658864739 332 MPDEFSHLLRLHSQGVLKLH 351
Cdd:cd23969  256 MPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 99-350 8.18e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 170.91  E-value: 8.18e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739  99 TITQANTPVGSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLS 178
Cdd:cd23988   21 SVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 179 nGYEKHVGIKTDLVTANPSILLEKFGALMGR--RRKFVESLHSYGNSLLLLPAFSY-GHNTPVSLRAFYTLEDfESPVQP 255
Cdd:cd23988  101 -EFAADVGTKSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVkGGEKHVEWVNALILKN-KLKVRT 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 256 IFFNPGYLHNLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPF--DFHPYSFQTltnHYYDDRKTK----TKF 329
Cdd:cd23988  179 AYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFpkDANGNPVKY---HYYDDLKYRyfsnAGP 255

                        250       260
                 ....*....|....*....|.
gi 658864739 330 HAMPDEFSHLLRLHSQGVLKL 350
Cdd:cd23988  256 HRMPLEFKTLNVLHNRGALKL 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 108-352 1.27e-49

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 167.81  E-value: 1.27e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 108 GSKLVYDGEKKRTLQVNPEIFSTFFKGHPFPNKTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSNgYEKHVGI 187
Cdd:cd23987   30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 188 KTDLVTANPSILLEKFGALMGR--RRKFVESLHSYGNSLLLLPAF-SYGHNTPVSLRAFYTLEDFESpVQPIFFNPGYLH 264
Cdd:cd23987  109 KTDLVTMNPSVVQRAFEDLVNEtwKEKFLQRLQSLNGSILWIPAFmAKGGEERVEWVNDLILKHHIN-VRTAYPSLRLLH 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 265 NLALFWRSQGLRTIRLSTGIIMTSLALELCDNVQLYGFWPFDfHPYSFQTLTNHYYDDRK----TKTKFHAMPDEFSHLL 340
Cdd:cd23987  188 AVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFP-RDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKALK 266

                        250
                 ....*....|..
gi 658864739 341 RLHSQGVLKLHL 352
Cdd:cd23987  267 NLHQQGALKLTV 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 145-336 1.86e-30

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 114.77  E-value: 1.86e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 145 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGIKTDLVTANPSILlekfGALMGRRRKFVESLHSYGNSL 224
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWA----GFYLRGPRCGCHPLPLEEEVV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 225 LLLPAFSYGHNTPVSLRAFYtledfeSPVQPIFFNP--GYLHNLA---LFW--RSQGLRTIRLSTGIIMTSLALELCDNV 297
Cdd:cd19952   76 LILSRAAAADFKRLKRRKKR------HDNAVLLLTDpaPDLLSYVrkrLEKlgLKSFFGGNAPSSGLLAVLLALQLCDSV 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 658864739 298 QLYGFWPFDFHPYSFQtltNHYYDDRKT--KTKFHAMPDEF 336
Cdd:cd19952  150 DLYGFGVDSGHAPKVP---YHYYDLVEAeeGTAVHSFDLEA 187
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 144-353 4.12e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 92.12  E-value: 4.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNlPPLSNGYEKHVGIKTDLV--TANpSIL-----LEKFG---ALMGRRRKF 213
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFYvhTAH-SITsslmiLQKRGfknIPQDKDIKY 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 214 V---ESLHSYG--NSLLL---LPAFSYGHNTPvslRAFYTlEDFeSPVQPIFFNPGYLHNLA-LFWRSQGLRTI-----R 279
Cdd:cd23973  163 IlfpEGPRDYQwlEALLKnktIPSGAYYGRRP---RSYFS-GDF-TEDKYLVLHPDFLRYVKnRFLRSKTLKGKywaiyR 237

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658864739 280 LSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfqtltNHYYDDRKTKTKFHAMPD---EFSHLLRLHSQGVLKLHLG 353
Cdd:cd23973  238 PTTGAFLLLTALHLCDTVSAYGFITEDYRKYP-----DHYYDKKKTKLVFYINHDfrlEKKLWKRLHDEKIIKLYQR 309
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 144-351 3.16e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 89.24  E-value: 3.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLpPLSNGYEKHVGIKTDLVTANPSillekfgALMGRRRKFVesLHSYGNS 223
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNH-ALTKGFEKDVGTKTSFYTFFPE-------SLHNSLLKHV--PQDKDTK 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 224 LLLLPAFSY--------GHNTPV------------SLRAFYTLEDFESpVQPIFFNpgYLHNlalFW-RSQglRTIRLST 282
Cdd:cd23964  154 YLFIPFKIRdydyldavLSGKPVpdgcdkgkrpppLFGPKLNATNVRL-LHPDFIR--YLFN---RWlNSS--TSYRPTT 225

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658864739 283 GIIMTSLALELCDNVQLYGfwpFDFHPYSfqtlTNHYYDD-RKTKTKF---HAMPDEFSHLLRLHSQGVLKLH 351
Cdd:cd23964  226 GALMLLTALHTCDQVSVYG---FGYDPRF----SLHYYDKtFVKFTVFyanHDFTNERKLWRKLHEEGIINLY 291
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 145-338 9.15e-19

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 83.50  E-value: 9.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 145 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDLVTANPSillekfGAlmgrrrkFVESLHSYGNSL 224
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVK-GYEKDVGSKTTFRMFYPE------SA-------FRDPEEYDSDWL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 225 LLLPAFSyghntPVSLRAFYTLEDFESPVQPIFF------------------NPGYLHNLAL----FWRSQGLRTIRLST 282
Cdd:cd23967   71 LVLVPFK-----SMDLLWLQAVIKGKKPNGKGGFwkkiatsvpkppkkirilNPYILQEAAFdligLPMNGKQGKNVPTT 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 658864739 283 GIIMTSLALELCDNVQLYGFWpfdfHPYSFQTLTNHYYDDRKTKtkfhAMPDEFSH 338
Cdd:cd23967  146 GIIAIVMALHYCDEVDIAGFG----YDPSDPNAPLHYYDSLTMK----AIKRSWTH 193
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 144-322 1.15e-17

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 80.56  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDLVTANP-SIllekfgalmgrrrkFVESLHSYGN 222
Cdd:cd23984    4 KCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTTFRLCYPeSI--------------FSDPSHYDPN 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 223 SLLLLPAFS----------YGHNtPVSLRAFYT---LEDFESPVQPIFFNPGYLHNLALFWRSQGLR------TIRLSTG 283
Cdd:cd23984   69 TTVVLIPFKphdlrwlldlLMGK-KVSAKGFWKkpaLNLIYKPNQIRILNPFILRIAAYELLHFPKRfpkekkPKHPTTG 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 658864739 284 IIMTSLALELCDNVQLYGFwpfdfhPYSFQTLTN--HYYDD 322
Cdd:cd23984  148 IIAITLALHICNEVHIAGF------KYDFSNLNStlHYYGN 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 145-352 3.13e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 78.26  E-value: 3.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 145 CAVVGNGGILANSSCGKMIDSAEFVIRCNlPPLSNGYEKHVGIKTDLVTANPSILLEKFGALMG---------RRRKFVe 215
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGvgfngppqsKETRYI- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 216 SLHSYGNSLLLLPAFSYghNTPVS---------LRAF---YTLEDFESpVQPIFFNpgYLHNLalFWRSQGLRT-----I 278
Cdd:cd23974  165 FLPDHDRDYLLVKAALT--HTPIDrgrdkskrpSKYFgkdVTAEKFKI-YHPDFIR--YLRNR--FLWSPILNTkqrdiY 237

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658864739 279 RLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfqtltNHYYDDRKTKTKF---HAMPDEFSHLLRLHSQGVLKLHL 352
Cdd:cd23974  238 RPSTGAVMLLAALHTCDQVSAYGFMTPDYGKYS-----DHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKLYM 309
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 118-328 2.59e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 75.00  E-value: 2.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 118 KRTLQVNPEIFSTF-FKGHPFPN------KTWHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTD 190
Cdd:cd23968   14 FSTLRKTTSPFKDLlSLRYPFPEsslentKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTK-GFEKDVGSKTT 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 191 LVTANPSIllekfgaLMGRRRKFVESLHsYGNSLLLL--PAfSYGhntpVSLRAFYTLEDFES-----------PVQPIF 257
Cdd:cd23968   93 LRLINSQI-------LSKPEFNFLTDPL-YRNVTLLVwdPS-SYN----VNLEKWYKKPDFDFfpnyikyrrrhPEEPFY 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 658864739 258 F-NPGYLHNLalfW----RSQGLRTIRL--STGIIMTSLALELCDNVQLYGFWPfdfhpySFQTLTN-HYYDDRKTKTK 328
Cdd:cd23968  160 LiDPRFLWRL---WdilqEYTPEKIKPNppSSGFIGIVLMLHLCDWVDVYEYVP------SVRQTDRcHYYDVEKDLAC 229
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 129-351 3.37e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 75.25  E-value: 3.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 129 STFFKGHPFPNKTWHtCAVVGNGGILANSSCGKMIDSAEFVIRCNlPPLSNGYEKHVGIKTDL------VTANPSILLEK 202
Cdd:cd23972   70 AKLFFPRDTPGKCIR-CAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygftvnTMKNSLISYWN 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 203 FGAL-----MGRRRKFVES-------LHSygnSLLLLPAFSyGHNTPVSLRAFYTLEdfESPVQPIFFNPGYLHNLA-LF 269
Cdd:cd23972  148 LGFTrtpqgQDLQYIFIPSdirdyvmLRS---AILGVPVPE-GLDKGDRPHKYFGPE--ASAKKFKLLHPDFISYLTdRF 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 270 WRSQGLRT-----IRLSTGIIMTSLALELCDNVQLYGFWPFDFHPYSfqtltNHYYDDRKTKTKFHAMPD---EFSHLLR 341
Cdd:cd23972  222 LKSKLLNThyghlYMPSTGALMLLTALHTCDQVSAYGFITSNYWKFS-----DHYYERKKKPLVFYANHDmllEAALWRR 296

                        250
                 ....*....|
gi 658864739 342 LHSQGVLKLH 351
Cdd:cd23972  297 LHKAGILQLY 306
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 144-351 1.50e-14

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 73.08  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDlvtanpsillekfgalmgRRRKFVESLHSY--G 221
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTK-GFEKDVGSKTT------------------HHFMYPESAVDLdpG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 222 NSLLLLP-----------AFSYGH--NTPVSLRAFYTLEdfESPVQpiFFNPGYLHNLALFW-RSQGlrtiRL-STGIIM 286
Cdd:cd23966  140 VHLVLVPfkvldlqwlisALTTGEitRTYTPVKRFIKAD--KDKVL--VINPAFIKYVHDNWtEHHG----RYpSTGFLA 211

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 658864739 287 TSLALELCDNVQLYGF-------WpfdfhpysfqtltNHYYDD-----RKTKTKFHAMPDEFSHLLRLHSQGVLKLH 351
Cdd:cd23966  212 LIFALHICDEVSVFGFgadskgnW-------------HHYWEKnrsagAFRKTGVHDADFESDIIKKLAKEGKIRVY 275
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 143-326 2.30e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 71.50  E-value: 2.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 143 HTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDL-VTANPSIllekfgALMGRRRKFVESLHSYG 221
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTR-GYEKDVGRRTTIrVVSHSSL------PRLLRNAILLLAGTRAP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 222 NSLLLlpafsYGHNTPVSLRAFYT------LEDFESPVQPIFFNPG-YLHNLALFWRSQGL-RTIR---LSTGIIMTSLA 290
Cdd:cd23965   75 TVVVF-----WGPETKMNKDGAGKynllrsLSKKYPDVEFYSLTPEkMDYADELFEKETGKsRIKSgtwLSTGWFTMLLA 149

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 658864739 291 LELCDNVQLYGFWPFDF---HPYSfqTLTNHYYDDRKTK 326
Cdd:cd23965  150 LDVCDEIKVYGMVPENYcreHPNS--KVPYHYYEPGGLK 186
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 144-342 4.36e-14

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 70.08  E-value: 4.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDLVTANPsillekfgalmgRRRKFVESLHSYGNS 223
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVR-GFEKDVGSKTTIRLFYP------------ESAQFDPGIENDPDT 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 224 LLLLPAFSyghntPVSLRAFYTLEDFESPVQPIFF-----------------NPGYLHNLALFWRS---QGLRTIRLSTG 283
Cdd:cd23982   71 LLVLVPFK-----PLDFYWLYEILSNEKRVRKGFWkqppriwdanpkqirilNPYYTYVAATKLLQvpgQRKKKQKPTTG 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 658864739 284 IIMTSLALELCDNVQLYGF-WPFDFHPYSFQtltnHYYDD---RKTKTKFHAMPDEFSHLLRL 342
Cdd:cd23982  146 LLAITLALHLCDEVHIAGFgYPDNGNSNQPI----HYYNQitlKSMANSGHNLNAEAQAIQRL 204
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 145-334 3.02e-10

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 59.37  E-value: 3.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 145 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLsNGYEKHVGIKTDLVTANPSillekfGAlmgrrrkfVESLHSYGNSL 224
Cdd:cd23983    5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPE------GA--------PKSEQEYDPTS 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 225 LLLpAFSYGH-----------NTPVSL--RAFYTLEDFES-PVQPIFF---NPGYLHNLAL------------FWRSQGL 275
Cdd:cd23983   70 LFV-AVLFKSvdfawlkamvkKEPLSFwsRLFFWKEVADSiPLKPSQFrilNPLIIKETALdilqypepqsrlWGWDKNV 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 658864739 276 RTIrlstGIIMTSLALELCDNVQLYGFwpfdfhPYSFQTLTN--HYYDDRKTKT-KFHAMPD 334
Cdd:cd23983  149 PTL----GVTAVVLATHLCDEVSLAGF------GYDLSQPHAplHYYDSVCMAAmNTQTMHN 200
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 145-202 1.61e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 57.24  E-value: 1.61e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 658864739 145 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLsNGYEKHVGIKTDLVTANPSILLEK 202
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAIQK 61
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 144-321 2.11e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 57.54  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGIKTDLVTANPSILLEKfgalmgrRRKFVESlHSYGNS 223
Cdd:cd23986   51 SCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNP-------NHHFIDS-SLYKDV 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 224 LLLL--PAFSYghntpVSLRAFYTLEDF-----------ESPVQPIF-FNPGYLHNLALFWRSQGLRTIRL---STGIIM 286
Cdd:cd23986  122 ILVAwdPAPYS-----ANLHKWYKKPDYnlftpyvqyrkRNPNQPFYiLHPKFIWQLWDIIQENTQEKIQPnppSSGFIG 196

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 658864739 287 TSLALELCDNVQLYgfwpfDFHPYSFQTLTNHYYD 321
Cdd:cd23986  197 ILIMMSMCREVHVY-----EYIPSVRQTDLCHYHE 226
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 125-302 3.74e-09

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 57.19  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 125 PEIFSTFFKGHP--FPNKTW-----HTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGIKTDL------ 191
Cdd:cd23979   56 KEVLSKLFQIIPgeNPYRSWdpsrcRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGSRTTHhfmype 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 192 ----VTANPSILLEKFGALmgrrrkfveslhsygNSLLLLPAFSYGH--NTPVSLRAFYTLEdfESPVQpiFFNPGYLHN 265
Cdd:cd23979  135 saknLPANVSFVLVPFKTL---------------DLLWITSALSTGQirFTYAPVKQFLRVD--KDKVQ--IYNPAFFKY 195

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 658864739 266 LALFWRSQGLRTIrlSTGIIMTSLALELCDNVQLYGF 302
Cdd:cd23979  196 IHDRWTEHHGRYP--STGMLVLFFALHVCDEVNVYGF 230
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 143-323 1.33e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 54.86  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 143 HTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDL-VTANPSIllekFGALmgRRRKFVESLHSyg 221
Cdd:cd23978    2 HQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTT-GYEKDVGNKTTLrVVAHSSV----YRVL--RRPQEFLNRTP-- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 222 NSLLLLpafsYGHNTPVSLRAFYTLEDFESPVQPIFFN-------PGYLHNL-ALFWRSQGLRTIR----LSTGIIMTSL 289
Cdd:cd23978   73 ETTLIF----WGPPNKMQKDGKSNLFRIIQRASMTFPNmsafvvsPRRMRQFdDLFRGETGRDRKKshswLSTGWFTMVI 148

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 658864739 290 ALELCDNVQLYGFWPFDF--HPYSFQTLTNHYYDDR 323
Cdd:cd23978  149 AVELCDNVHVYGMVPPNYcsKRPTPKKMPYHYYEPK 184
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 120-320 1.67e-08

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 54.71  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 120 TLQVNPEIFSTFFKGHPFPNKT-------WHTCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPLSnGYEKHVGIKTDLV 192
Cdd:cd23985   16 MLEGTDFPFNTSEWEGYLPKKSlreevgpLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGTKTTIR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 193 TANPSIL-LEKfgalmgrrRKFV-ESLHSYGNSLLLLPAfSYGHNTPvslrafytlEDFESPVQPIFFN----------- 259
Cdd:cd23985   95 LINSQLVtTEK--------HKFLkDSLYNEGILIVWDPA-PYHSDIP---------EWYKNPDYNFFENyktyrrlnpnq 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 260 PGYLHNLALFWR---------SQGLRTIRLSTGIIMTSLALELCDNVQLYgfwpfDFHPYSFQTLTNHYY 320
Cdd:cd23985  157 PFYILHPQMQWElwdiiqensPEEIQPNPPSSGMLGIILMMTLCDQVDVY-----EFLPSKRKTDVCHYY 221
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 144-302 2.50e-07

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 51.42  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGIKTDLVTANPsillEKFgalmgrrRKFVESLhsygnS 223
Cdd:cd23980   83 RCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYP----ESF-------RELAQNV-----S 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 224 LLLLPAFSYGHNTPVSLRAFYTLEDFESPV---------QPIFFNPGYLHNLALFWRSQGLRTIrlSTGIIMTSLALELC 294
Cdd:cd23980  146 MILVPFKTLDLEWVISATTTGTISHTYVPVprkikvkkeKILIYHPAFIKYVFDRWLQGHGRYP--STGILSVIFSLHVC 223


                 ....*...
gi 658864739 295 DNVQLYGF 302
Cdd:cd23980  224 DEVDLYGF 231
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 144-321 4.79e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 50.25  E-value: 4.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 144 TCAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGIKTDL-VTANPSIllekfGALMGRRRKFVESlhSYGN 222
Cdd:cd23976   17 SCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLrVIAHSSI-----QRILRNRNELLNV--SQGT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 223 SLLLLPAFSYGHNTPVSLraFYTLEDFESPVQP-----IFFNPGYLHNLALFWRSQGL-RTIR---LSTGIIMTSLALEL 293
Cdd:cd23976   89 VFIFWGPSNYMRRDGKGL--VYNNLQLMNQILPklkvyTITRHKMLQFDELFKRETGKdRKISntwLSTGWFTMIIALEL 166

                        170       180       190
                 ....*....|....*....|....*....|...
gi 658864739 294 CDNVQLYGFWPFDF-----HPysfqTLTNHYYD 321
Cdd:cd23976  167 CDRINVYGMVPPDFcrdpnHP----SVPYHYYE 195
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 145-301 1.76e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 42.54  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 145 CAVVGNGGILANSSCGKMIDSAEFVIRCNLPPlSNGYEKHVGIKTDL-VTANPSI--LLEKFG-----------ALMGRR 210
Cdd:cd23977    4 CAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLrVVSHTSVplLLRNQGyffqqsrdtkyVIWGPE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 658864739 211 RKFVESLHSYGNSLLLLPAFSYGHNTpvslraFYTLEdfESPVQpiffnpgylHNLALFWRSQGLRTIR----LSTGIIM 286
Cdd:cd23977   83 RNMDRDGGGKTYRALLTLAKMYPHLQ------VYTLT--EEKMA---------YCDGVFQNETGKNRMKsgsfLSTGWFT 145

                        170
                 ....*....|....*
gi 658864739 287 TSLALELCDNVQLYG 301
Cdd:cd23977  146 MILALELCEEILVYG 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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