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Conserved domains on  [gi|66774158|sp|O75787|]
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RecName: Full=Renin receptor; AltName: Full=ATPase H(+)-transporting lysosomal accessory protein 2; AltName: Full=ATPase H(+)-transporting lysosomal-interacting protein 2; AltName: Full=ER-localized type I transmembrane adapter; AltName: Full=Embryonic liver differentiation factor 10; AltName: Full=N14F; AltName: Full=Renin/prorenin receptor; AltName: Full=Vacuolar ATP synthase membrane sector-associated protein M8-9; Short=ATP6M8-9; Short=V-ATPase M8.9 subunit; Contains: RecName: Full=Renin receptor N-terminal fragment; Contains: RecName: Full=Renin receptor C-terminal fragment; Flags: Precursor

Protein Classification

Renin_r domain-containing protein( domain architecture ID 10545182)

Renin_r domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Renin_r pfam07850
Renin receptor-like protein; The sequences featured in this family are similar to a region of ...
 254-350 5.10e-56

Renin receptor-like protein; The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.


:

Pssm-ID: 462287  Cd Length: 97  Bit Score: 177.89  E-value: 5.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66774158   254 LYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDP 333
Cdd:pfam07850   1 LYGGNAVVELVTVKAFDGILKRKKRSILQAKQANDPKTPYNLAYKYSSDYPVIFNIILWLMVALVLALIVISYGLWNMDP 80

                          90
                  ....*....|....*..
gi 66774158   334 GYDSIIYRMTNQKIRMD 350
Cdd:pfam07850  81 GRDSIIYRMTTTRMKKD 97
 
Name Accession Description Interval E-value
Renin_r pfam07850
Renin receptor-like protein; The sequences featured in this family are similar to a region of ...
 254-350 5.10e-56

Renin receptor-like protein; The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.


Pssm-ID: 462287  Cd Length: 97  Bit Score: 177.89  E-value: 5.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66774158   254 LYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDP 333
Cdd:pfam07850   1 LYGGNAVVELVTVKAFDGILKRKKRSILQAKQANDPKTPYNLAYKYSSDYPVIFNIILWLMVALVLALIVISYGLWNMDP 80

                          90
                  ....*....|....*..
gi 66774158   334 GYDSIIYRMTNQKIRMD 350
Cdd:pfam07850  81 GRDSIIYRMTTTRMKKD 97
 
Name Accession Description Interval E-value
Renin_r pfam07850
Renin receptor-like protein; The sequences featured in this family are similar to a region of ...
 254-350 5.10e-56

Renin receptor-like protein; The sequences featured in this family are similar to a region of the human renin receptor that bears a putative transmembrane spanning segment. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface.


Pssm-ID: 462287  Cd Length: 97  Bit Score: 177.89  E-value: 5.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66774158   254 LYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDP 333
Cdd:pfam07850   1 LYGGNAVVELVTVKAFDGILKRKKRSILQAKQANDPKTPYNLAYKYSSDYPVIFNIILWLMVALVLALIVISYGLWNMDP 80

                          90
                  ....*....|....*..
gi 66774158   334 GYDSIIYRMTNQKIRMD 350
Cdd:pfam07850  81 GRDSIIYRMTTTRMKKD 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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