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Conserved domains on  [gi|66820640|ref|XP_643905|]
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COMM domain-containing protein 5 [Dictyostelium discoideum AX4]

Protein Classification

COMM domain-containing protein( domain architecture ID 4715)

COMM (copper metabolism gene MURR1) domain-containing protein is involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 95-203 9.49e-51

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04753:

Pssm-ID: 471425  Cd Length: 110  Bit Score: 159.53  E-value: 9.49e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820640  95 DLKLPQNLITDLTNIYNTQSKDLAERSNNDKI-LFPQLSSFKWRVDVIISSSFTSRVLNPVILMEMNDTNGKSKVFEVSI 173
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGvRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 66820640 174 DNFHKLRYNAAKLLKDLEDLEQIQILSKLE 203
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 95-203 9.49e-51

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 159.53  E-value: 9.49e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820640  95 DLKLPQNLITDLTNIYNTQSKDLAERSNNDKI-LFPQLSSFKWRVDVIISSSFTSRVLNPVILMEMNDTNGKSKVFEVSI 173
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGvRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 66820640 174 DNFHKLRYNAAKLLKDLEDLEQIQILSKLE 203
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 128-182 8.75e-11

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 55.63  E-value: 8.75e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 66820640   128 FPQLSSFKWRVDVIISSSFTSRVLNPVILMEMNDTNGKSK----VFEVSIDNFHKLRYN 182
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSseevTFELSKEQLQDLLNE 60
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 95-203 9.49e-51

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 159.53  E-value: 9.49e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820640  95 DLKLPQNLITDLTNIYNTQSKDLAERSNNDKI-LFPQLSSFKWRVDVIISSSFTSRVLNPVILMEMNDTNGKSKVFEVSI 173
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGvRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 66820640 174 DNFHKLRYNAAKLLKDLEDLEQIQILSKLE 203
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 128-182 8.75e-11

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 55.63  E-value: 8.75e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 66820640   128 FPQLSSFKWRVDVIISSSFTSRVLNPVILMEMNDTNGKSK----VFEVSIDNFHKLRYN 182
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSseevTFELSKEQLQDLLNE 60
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 129-198 4.61e-07

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 46.15  E-value: 4.61e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820640 129 PQLSSFKWRVDVIISSSFTSRVLNPVILMEMNDTNGKSKVFEvsidnFHKLRYNAAKLLKDLEDLEQIQI 198
Cdd:cd04748  21 PQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSE-----KICFEMTKEELQNFLNKLKKIKA 85
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 72-181 3.34e-05

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 42.80  E-value: 3.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66820640  72 LYYILKVALKKKVSNQIFVADITDLKLPQNLITDLTNIYNTQSKDLAERSNNDKILFPQLSSFKWRVDVIISSSFTSRVL 151
Cdd:cd04752  48 LSFILSSAAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVN 127

                        90       100       110
                ....*....|....*....|....*....|....*
gi 66820640 152 NPVILMEMNDTNG-----KSKVFEVSIDNFHKLRY 181
Cdd:cd04752 128 EPLVQLRLKVRNAdtgeiTPHPFSVSADKFRVLLA 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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