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Conserved domains on  [gi|68125904|emb|CAJ03579|]
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putative phosphatidic acid phosphatase [Leishmania major strain Friedlin]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Homo sapiens phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 191-386 4.04e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 188.58  E-value: 4.04e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 191 SLRTPFANtyHEHTGSRESAAVADALPSRATASAPCRQkahtyalvhpwQRFLLHVHIWFLTQAFSVVFALMVVSAIKVY 270
Cdd:cd03390   2 SISYPFAE--SETVPTWLLVIISVGIPLLVIILISLFF-----------RRSLWDLHTSLLGLLLSVSLNGVITNVLKNY 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 271 AGRLRPDFLSRLRNEGYSPQSTGV-------DWCAVPKEGRVSFPSGHSSISFSAIVPFCFYVLHSLRAFRRSGvSLWRI 343
Cdd:cd03390  69 AGRPRPDFLARCFPDGGTPSDTLVgidicctGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRG-SSWRL 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 68125904 344 FTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:cd03390 148 LLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSY 190
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 191-386 4.04e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 188.58  E-value: 4.04e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 191 SLRTPFANtyHEHTGSRESAAVADALPSRATASAPCRQkahtyalvhpwQRFLLHVHIWFLTQAFSVVFALMVVSAIKVY 270
Cdd:cd03390   2 SISYPFAE--SETVPTWLLVIISVGIPLLVIILISLFF-----------RRSLWDLHTSLLGLLLSVSLNGVITNVLKNY 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 271 AGRLRPDFLSRLRNEGYSPQSTGV-------DWCAVPKEGRVSFPSGHSSISFSAIVPFCFYVLHSLRAFRRSGvSLWRI 343
Cdd:cd03390  69 AGRPRPDFLARCFPDGGTPSDTLVgidicctGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRG-SSWRL 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 68125904 344 FTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:cd03390 148 LLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSY 190
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 254-386 2.99e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 2.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904   254 AFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQSTGvdwcavpkEGRVSFPSGHSSISFSAIVPFCFYvLHSLRAF 333
Cdd:pfam01569   3 LLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP--------GLGYSFPSGHSATAFALALLLALL-LRRLRKI 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 68125904   334 rrsgvslWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:pfam01569  74 -------VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PLN02250 PLN02250
lipid phosphate phosphatase
 246-382 4.40e-16

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 78.43  E-value: 4.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904  246 VHIWFLTQAFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEG---YSPQSTGVdWC----AVPKEGRVSFPSGHSSISFSA 318
Cdd:PLN02250  96 LHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGkgvFHPVTTDV-LCtgakSVIKEGHKSFPSGHTSWSFAG 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68125904  319 IVPFCFYVLHSLRAFRRSGvSLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSA 382
Cdd:PLN02250 175 LGFLSLYLSGKIRVFDRRG-HVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA 237
acidPPc smart00014
Acid phosphatase homologues;
258-386 2.98e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 68.91  E-value: 2.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904    258 VFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQStgvdwcaVPKEGRVSFPSGHSSISFSAivpFCFYVLHSLRAFRRSG 337
Cdd:smart00014   5 VVSQLFNGVIKNYFGRPRPFFLSIGDACCTPNFL-------LTLEAGYSFPSGHTAFAFAF---ALFLLLYLPARAGRKL 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 68125904    338 VSLwriftglLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:smart00014  75 LIF-------LLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 233-386 2.24e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 59.67  E-value: 2.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 233 YALVHPWQRFLLHVHIWFLTQAFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQSTgvdwcavpkegrvSFPSGHS 312
Cdd:COG0671  58 LLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGY-------------SFPSGHA 124

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68125904 313 SISFSAIVPFCFYvlhslrafrrsgvsLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:COG0671 125 AAAFALALVLALL--------------LPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 191-386 4.04e-58

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 188.58  E-value: 4.04e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 191 SLRTPFANtyHEHTGSRESAAVADALPSRATASAPCRQkahtyalvhpwQRFLLHVHIWFLTQAFSVVFALMVVSAIKVY 270
Cdd:cd03390   2 SISYPFAE--SETVPTWLLVIISVGIPLLVIILISLFF-----------RRSLWDLHTSLLGLLLSVSLNGVITNVLKNY 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 271 AGRLRPDFLSRLRNEGYSPQSTGV-------DWCAVPKEGRVSFPSGHSSISFSAIVPFCFYVLHSLRAFRRSGvSLWRI 343
Cdd:cd03390  69 AGRPRPDFLARCFPDGGTPSDTLVgidicctGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRG-SSWRL 147

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 68125904 344 FTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:cd03390 148 LLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSY 190
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 254-386 2.99e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 2.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904   254 AFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQSTGvdwcavpkEGRVSFPSGHSSISFSAIVPFCFYvLHSLRAF 333
Cdd:pfam01569   3 LLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP--------GLGYSFPSGHSATAFALALLLALL-LRRLRKI 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 68125904   334 rrsgvslWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:pfam01569  74 -------VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 247-386 3.95e-19

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 82.51  E-value: 3.95e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 247 HIWFLTQAFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQSTGVDWcavpkegrvSFPSGHSSISFSAIVPFCFYV 326
Cdd:cd01610   2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLLLTEGGY---------SFPSGHAAFAFALALFLALLL 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 327 LHSLrafrrsgvslWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:cd01610  73 PRRL----------LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 254-386 3.52e-17

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 78.06  E-value: 3.52e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 254 AFSVVFALMVVSAIKVYAGRLRPDFLSRLR------NEGYSPQSTGVDWC-----AVPKEGRVSFPSGHSSISFSAIVpf 322
Cdd:cd03384  10 LFGLFATQLLTDLGKYVTGRLRPHFLDVCKpnytdlTCSLDHQYIADCTCctgdpDLIREARLSFPSGHASLSMYAAV-- 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68125904 323 cFYVLHSLRAFRRSGVSLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:cd03384  88 -FLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PLN02250 PLN02250
lipid phosphate phosphatase
 246-382 4.40e-16

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 78.43  E-value: 4.40e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904  246 VHIWFLTQAFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEG---YSPQSTGVdWC----AVPKEGRVSFPSGHSSISFSA 318
Cdd:PLN02250  96 LHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGkgvFHPVTTDV-LCtgakSVIKEGHKSFPSGHTSWSFAG 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68125904  319 IVPFCFYVLHSLRAFRRSGvSLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSA 382
Cdd:PLN02250 175 LGFLSLYLSGKIRVFDRRG-HVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA 237
acidPPc smart00014
Acid phosphatase homologues;
258-386 2.98e-14

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 68.91  E-value: 2.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904    258 VFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQStgvdwcaVPKEGRVSFPSGHSSISFSAivpFCFYVLHSLRAFRRSG 337
Cdd:smart00014   5 VVSQLFNGVIKNYFGRPRPFFLSIGDACCTPNFL-------LTLEAGYSFPSGHTAFAFAF---ALFLLLYLPARAGRKL 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 68125904    338 VSLwriftglLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:smart00014  75 LIF-------LLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 240-384 4.70e-12

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 66.59  E-value: 4.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904  240 QRFLLHVHIWFLTQAFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSP-QSTGVDWC----AVPKEGRVSFPSGHSSI 314
Cdd:PLN02731 109 RRDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALyDSLGDVIChgdkSVIREGHKSFPSGHTSW 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904  315 SFSAIVPFCFYVLHSLRAFRRSGvSLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVI 384
Cdd:PLN02731 189 SFSGLGFLSLYLSGKIQAFDGKG-HVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTI 257
PLN02715 PLN02715
lipid phosphate phosphatase
 246-382 1.36e-11

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 65.08  E-value: 1.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904  246 VHIWFLTQAFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSP-QSTGVDWC----AVPKEGRVSFPSGHSSISFSAIV 320
Cdd:PLN02715 121 LHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELyDALGGVIChgkaAEVKEGHKSFPSGHTSWSFAGLT 200

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 68125904  321 PFCFYVLHSLRAFRRSGvSLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSA 382
Cdd:PLN02715 201 FLSLYLSGKIKAFNGEG-HVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVA 261
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 254-386 1.72e-10

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 57.73  E-value: 1.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 254 AFSVVFALMVVSAIKVYAGRLRPDflsrLRNEGYSpqstgvdwcavpkegrvSFPSGHSSISFSAIVpfcfyvLHSLRAF 333
Cdd:cd03394   9 AEAAALTAAVTEGLKFAVGRARPD----GSNNGYR-----------------SFPSGHTASAFAAAT------FLQYRYG 61

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 68125904 334 RRSgVSLWRIftgllplILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:cd03394  62 WRW-YGIPAY-------ALASLVGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 233-386 2.24e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 59.67  E-value: 2.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 233 YALVHPWQRFLLHVHIWFLTQAFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQSTgvdwcavpkegrvSFPSGHS 312
Cdd:COG0671  58 LLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGY-------------SFPSGHA 124

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68125904 313 SISFSAIVPFCFYvlhslrafrrsgvsLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIAV 386
Cdd:COG0671 125 AAAFALALVLALL--------------LPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 255-384 6.22e-08

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 52.32  E-value: 6.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 255 FSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSPQSTGVDWcavpkegrVSFPSGHSSISFSAIVPFCFYvlhslraFR 334
Cdd:cd03389  76 ATVALSGILVNLLKFIIGRARPKLLFDDGLYGFDPFHADYAF--------TSFPSGHSATAGAAAAALALL-------FP 140

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 68125904 335 RsgvslWRiftgLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVI 384
Cdd:cd03389 141 R-----YR----WAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALA 181
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 254-385 7.57e-08

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 52.23  E-value: 7.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 254 AFSVVFALMVVSAIKVYAGRLRPDFLSRLRNEGYSpqstgvdwcavpkegrvsFPSGHSSISFsAIVPFCFYVLhslraF 333
Cdd:cd03392  68 LLALLGGGALNTLLKLLVQRPRPPLHLLVPEGGYS------------------FPSGHAMGAT-VLYGFLAYLL-----A 123

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 68125904 334 RRSGVSLWRIFTGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIA 385
Cdd:cd03392 124 RRLPRRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALL 175
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 248-382 1.03e-05

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 45.72  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 248 IWFLTQAFSVVFA-LMVVSAIKVYAGRLRPDFlsrlrnegysPQSTGVDWCAVPKEGRVSFPSGHSSISFSAIVPFCFYv 326
Cdd:cd03395  56 LILLLVLLAVGFAdQLASGFLKPLVARLRPCN----------ALDGVRLVVLGDQGGSYSFASSHAANSFALALFIWLF- 124

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 68125904 327 lhslraFRRsgvslwRIFTGLLpLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSA 382
Cdd:cd03395 125 ------FRR------GLFSPVL-LLWALLVGYSRVYVGVHYPGDVIAGALIGIISG 167
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 255-385 4.14e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 43.46  E-value: 4.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 255 FSVVFALMVVSAIKVYAGRLRPdflsrLRNEGYSPQSTGVDwcavpkegRVSFPSGHSSISFsaivpFCFYVLHSLRAfr 334
Cdd:cd03391  54 LGLLLDIITVAILKALVRRRRP-----AYNSPDMLDYVAVD--------KYSFPSGHASRAA-----FVARFLLNHLV-- 113

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 68125904 335 rsgvsLWRIFTGLLpLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIA 385
Cdd:cd03391 114 -----LAVPLRVLL-VLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLV 158
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 306-386 9.00e-04

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 39.55  E-value: 9.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 306 SFPSGHSSISFSaiVPFCFYVLHSLRAfrrsgvslwriftGLLPLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIA 385
Cdd:cd03385  78 SFPSDHTTLFFS--IAFSLLLRRRKWA-------------GWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLV 142


                .
gi 68125904 386 V 386
Cdd:cd03385 143 F 143
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 250-385 1.22e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 39.98  E-value: 1.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68125904 250 FLTQAFSVVFALMVVSAIKVYAGRLRP--------DFLSRLRNEGYSPQSTGvdwcavpkeGRvSFPSGHSSISFSAIVP 321
Cdd:cd03396  69 LLLLILVIGLGLLVVAILKSHWGRPRPwdltefggDAPYTPLFSGPSNGCGK---------GC-SFPSGHASAGFALLAL 138

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68125904 322 FCFyvlhsLRAFRRSGVSLWRIFTgllpLILPIAVAVSRTRDNRHYFDDIVAGSAIGIVSAVIA 385
Cdd:cd03396 139 YFL-----FRRRRPRLARLVLAAG----LALGALMGLARMARGAHFLSDVLWSLLLVWLIALLL 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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