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Conserved domains on  [gi|686153059|ref|WP_031785700|]
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helix-turn-helix domain-containing protein, partial [Staphylococcus aureus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13355 super family cl36239
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 3-129 1.46e-09

bifunctional HTH-domain containing protein/aminotransferase; Provisional


The actual alignment was detected with superfamily member PRK13355:

Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 55.51  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686153059   3 EKVSNRLKHIMKIRNLKQVDIINKSKpyqkQLGISLSKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWLMGYDVNSYRV 82
Cdd:PRK13355   2 TTFAERLKQAMKARGLKQEDLVHAAE----ARGVKLGKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPADQE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 686153059  83 PDEERQEETVMSKINNISSQLTPPRQSNVLNYANSQLDEQNKVTSID 129
Cdd:PRK13355  78 SDASAVVESAPNSHLADPSAPTTPISQTSSEISIGNRRTFKKSHKLD 124
 
Name Accession Description Interval E-value
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 3-129 1.46e-09

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 55.51  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686153059   3 EKVSNRLKHIMKIRNLKQVDIINKSKpyqkQLGISLSKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWLMGYDVNSYRV 82
Cdd:PRK13355   2 TTFAERLKQAMKARGLKQEDLVHAAE----ARGVKLGKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPADQE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 686153059  83 PDEERQEETVMSKINNISSQLTPPRQSNVLNYANSQLDEQNKVTSID 129
Cdd:PRK13355  78 SDASAVVESAPNSHLADPSAPTTPISQTSSEISIGNRRTFKKSHKLD 124
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-72 5.91e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 41.73  E-value: 5.91e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686153059     8 RLKHIMKIRNLKQVDIinkskpyQKQLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWL 72
Cdd:smart00530   1 RLKELREEKGLTQEEL-------AEKLGVS--RSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-72 6.90e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.38  E-value: 6.90e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686153059   6 SNRLKHIMKIRNLKQVDIinkskpyQKQLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWL 72
Cdd:cd00093    1 GERLKELRKEKGLTQEEL-------AEKLGVS--RSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-89 1.34e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.52  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686153059   1 MREKVSNRLKHIMKIRNLKQVDIINKskpyqkqLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWLMGYDVNSY 80
Cdd:COG1396    4 LKKALGERLRELRKARGLTQEELAER-------LGVS--RSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEEL 74


                 ....*....
gi 686153059  81 RVPDEERQE 89
Cdd:COG1396   75 PEALLSEEE 83
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 9-72 2.67e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 39.83  E-value: 2.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 686153059    9 LKHIMKIRNLKQVDIinkskpyQKQLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWL 72
Cdd:pfam01381   1 LKELREELGLSQEEL-------AEKLGVS--RSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
 
Name Accession Description Interval E-value
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 3-129 1.46e-09

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 55.51  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686153059   3 EKVSNRLKHIMKIRNLKQVDIINKSKpyqkQLGISLSKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWLMGYDVNSYRV 82
Cdd:PRK13355   2 TTFAERLKQAMKARGLKQEDLVHAAE----ARGVKLGKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGGESPADQE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 686153059  83 PDEERQEETVMSKINNISSQLTPPRQSNVLNYANSQLDEQNKVTSID 129
Cdd:PRK13355  78 SDASAVVESAPNSHLADPSAPTTPISQTSSEISIGNRRTFKKSHKLD 124
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-72 5.91e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 41.73  E-value: 5.91e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686153059     8 RLKHIMKIRNLKQVDIinkskpyQKQLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWL 72
Cdd:smart00530   1 RLKELREEKGLTQEEL-------AEKLGVS--RSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-72 6.90e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.38  E-value: 6.90e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686153059   6 SNRLKHIMKIRNLKQVDIinkskpyQKQLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWL 72
Cdd:cd00093    1 GERLKELRKEKGLTQEEL-------AEKLGVS--RSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-89 1.34e-05

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 41.52  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686153059   1 MREKVSNRLKHIMKIRNLKQVDIINKskpyqkqLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWLMGYDVNSY 80
Cdd:COG1396    4 LKKALGERLRELRKARGLTQEELAER-------LGVS--RSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEEL 74


                 ....*....
gi 686153059  81 RVPDEERQE 89
Cdd:COG1396   75 PEALLSEEE 83
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 9-72 2.67e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 39.83  E-value: 2.67e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 686153059    9 LKHIMKIRNLKQVDIinkskpyQKQLGISlsKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWL 72
Cdd:pfam01381   1 LKELREELGLSQEEL-------AEKLGVS--RSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-76 4.95e-04

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 36.75  E-value: 4.95e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 686153059   1 MREKVSNRLKHIMKIRNLKqvdiinkskpyQKQLG--ISLSKSTLSQYINDVQSPDQDRIYLLSKTLNVGEAWLMGYD 76
Cdd:COG1476    1 MKKKLGNRLKELRKERGLT-----------QEELAelLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLE 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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