ATP-binding cassette protein, partial [Mus musculus]
Protein Classification
P-loop NTPase family protein( domain architecture ID 1562424)
P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| P-loop_NTPase super family | cl38936 | P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
1-194 | 4.83e-125 | ||||
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families. The actual alignment was detected with superfamily member cd03288: Pssm-ID: 476819 [Multi-domain] Cd Length: 257 Bit Score: 354.21 E-value: 4.83e-125
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| Name | Accession | Description | Interval | E-value | ||||
| ABCC_SUR2 | cd03288 | ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The ... |
1-194 | 4.83e-125 | ||||
ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity. Pssm-ID: 213255 [Multi-domain] Cd Length: 257 Bit Score: 354.21 E-value: 4.83e-125
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| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
1-192 | 6.73e-65 | ||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 217.51 E-value: 6.73e-65
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| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
1-195 | 4.18e-60 | ||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 203.82 E-value: 4.18e-60
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| MdlB | COG1132 | ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
1-192 | 1.15e-48 | ||||
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 167.65 E-value: 1.15e-48
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| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
1-132 | 1.86e-13 | ||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 65.36 E-value: 1.86e-13
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| AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
96-186 | 6.14e-03 | ||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 36.20 E-value: 6.14e-03
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| Name | Accession | Description | Interval | E-value | ||||
| ABCC_SUR2 | cd03288 | ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The ... |
1-194 | 4.83e-125 | ||||
ATP-binding cassette domain 2 of the sulfonylurea receptor SUR; The SUR domain 2. The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity. Pssm-ID: 213255 [Multi-domain] Cd Length: 257 Bit Score: 354.21 E-value: 4.83e-125
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| ABCC_MRP_domain2 | cd03244 | ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C ... |
1-185 | 1.10e-97 | ||||
ATP-binding cassette domain 2 of multidrug resistance-associated protein; The ABC subfamily C is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resistance lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213211 [Multi-domain] Cd Length: 221 Bit Score: 283.62 E-value: 1.10e-97
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| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
1-192 | 6.73e-65 | ||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 217.51 E-value: 6.73e-65
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| ABCC_NFT1 | cd03369 | ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type ... |
1-185 | 8.55e-64 | ||||
ATP-binding cassette domain 2 of NFT1, subfamily C; Domain 2 of NFT1 (New full-length MRP-type transporter 1). NFT1 belongs to the MRP (multidrug resistance-associated protein) family of ABC transporters. Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions such as glutathione, glucuronate, and sulfate. Pssm-ID: 213269 [Multi-domain] Cd Length: 207 Bit Score: 197.25 E-value: 8.55e-64
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| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
1-195 | 4.18e-60 | ||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 203.82 E-value: 4.18e-60
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| PLN03232 | PLN03232 | ABC transporter C family member; Provisional |
1-195 | 2.28e-58 | ||||
ABC transporter C family member; Provisional Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 198.66 E-value: 2.28e-58
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| ABCC_Glucan_exporter_like | cd03254 | ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ... |
1-193 | 4.48e-52 | ||||
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 167.79 E-value: 4.48e-52
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| PTZ00243 | PTZ00243 | ABC transporter; Provisional |
1-194 | 2.18e-50 | ||||
ABC transporter; Provisional Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 175.74 E-value: 2.18e-50
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| MdlB | COG1132 | ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
1-192 | 1.15e-48 | ||||
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 167.65 E-value: 1.15e-48
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| SunT | COG2274 | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ... |
1-192 | 5.41e-46 | ||||
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 161.93 E-value: 5.41e-46
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| CydD | COG4988 | ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease ... |
1-192 | 8.71e-45 | ||||
ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 444012 [Multi-domain] Cd Length: 563 Bit Score: 156.84 E-value: 8.71e-45
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| ABCC_CFTR2 | cd03289 | ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator ... |
1-194 | 5.22e-40 | ||||
ATP-binding cassette domain 2 of CFTR,subfamily C; The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2. Pssm-ID: 213256 [Multi-domain] Cd Length: 275 Bit Score: 138.45 E-value: 5.22e-40
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| ABCC_ATM1_transporter | cd03253 | ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ... |
1-192 | 6.80e-37 | ||||
ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213220 [Multi-domain] Cd Length: 236 Bit Score: 129.27 E-value: 6.80e-37
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| PRK10790 | PRK10790 | SmdB family multidrug efflux ABC transporter permease/ATP-binding protein; |
1-192 | 8.57e-36 | ||||
SmdB family multidrug efflux ABC transporter permease/ATP-binding protein; Pssm-ID: 182733 [Multi-domain] Cd Length: 592 Bit Score: 132.92 E-value: 8.57e-36
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| ABCC_MRP_Like | cd03228 | ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP ... |
1-177 | 3.44e-35 | ||||
ATP-binding cassette domain of multidrug resistance protein-like transporters; The MRP (Multidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a diverse functional spectrum that includes ion transport, cell surface receptor, and toxin secretion activities. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains, each composed of six transmembrane (TM) helices, and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213195 [Multi-domain] Cd Length: 171 Bit Score: 122.88 E-value: 3.44e-35
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| CFTR_protein | TIGR01271 | cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
1-192 | 5.54e-35 | ||||
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions] Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 131.57 E-value: 5.54e-35
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| ABC_MTABC3_MDL1_MDL2 | cd03249 | ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 ... |
1-192 | 8.37e-35 | ||||
ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the yeast MDL1 (multidrug resistance-like protein 1) and MDL2 (multidrug resistance-like protein 2) transporters are also included in this CD. MDL1 is an ATP-dependent permease that acts as a high-copy suppressor of ATM1 and is thought to have a role in resistance to oxidative stress. Interestingly, subfamily B is more closely related to the carboxyl-terminal component of subfamily C than the two halves of ABCC molecules are with one another. Pssm-ID: 213216 [Multi-domain] Cd Length: 238 Bit Score: 123.80 E-value: 8.37e-35
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| ABCC_MsbA | cd03251 | ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; ... |
1-192 | 1.31e-32 | ||||
ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213218 [Multi-domain] Cd Length: 234 Bit Score: 118.10 E-value: 1.31e-32
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| ABCC_bacteriocin_exporters | cd03245 | ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic ... |
1-179 | 1.12e-30 | ||||
ATP-binding cassette domain of bacteriocin exporters, subfamily C; Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors which have N-terminal leader peptides that share similarities in amino acid sequence and contain a conserved processing site of two glycine residues in positions -1 and -2. A dedicated ATP-binding cassette (ABC) transporter is responsible for the proteolytic cleavage of the leader peptides and subsequent translocation of the bacteriocins across the cytoplasmic membrane. Pssm-ID: 213212 [Multi-domain] Cd Length: 220 Bit Score: 112.68 E-value: 1.12e-30
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| NHLM_micro_ABC1 | TIGR03796 | NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; This protein describes ... |
33-191 | 1.52e-30 | ||||
NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; This protein describes a multidomain ABC transporter subunit that is one of three protein families associated with some regularity with a distinctive family of putative bacteriocins. It includes a bacteriocin-processing peptidase domain at the N-terminus. Model TIGR03793 describes a conserved propeptide region for this bacteriocin family, unusual because it shows obvious homology a region of the enzyme nitrile hydratase up to the classic Gly-Gly cleavage motif. This family is therefore predicted to be a subunit of a bacteriocin processing and export system characteristic to this system that we designate NHLM, Nitrile Hydratase Leader Microcin. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Biosynthesis of natural products] Pssm-ID: 274788 [Multi-domain] Cd Length: 710 Bit Score: 118.51 E-value: 1.52e-30
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| ABCC_Hemolysin | cd03252 | ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a ... |
1-191 | 4.69e-28 | ||||
ATP-binding cassette domain of hemolysin B, subfamily C; The ABC-transporter hemolysin B is a central component of the secretion machinery that translocates the toxin, hemolysin A, in a Sec-independent fashion across both membranes of E. coli. The hemolysin A (HlyA) transport machinery is composed of the ATP-binding cassette (ABC) transporter HlyB located in the inner membrane, hemolysin D (HlyD), also anchored in the inner membrane, and TolC, which resides in the outer membrane. HlyD apparently forms a continuous channel that bridges the entire periplasm, interacting with TolC and HlyB. This arrangement prevents the appearance of periplasmic intermediates of HlyA during substrate transport. Little is known about the molecular details of HlyA transport, but it is evident that ATP-hydrolysis by the ABC-transporter HlyB is a necessary source of energy. Pssm-ID: 213219 [Multi-domain] Cd Length: 237 Bit Score: 106.42 E-value: 4.69e-28
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| MsbA_lipidA | TIGR02203 | lipid A export permease/ATP-binding protein MsbA; This family consists of a single polypeptide ... |
1-191 | 2.35e-26 | ||||
lipid A export permease/ATP-binding protein MsbA; This family consists of a single polypeptide chain transporter in the ATP-binding cassette (ABC) transporter family, MsbA, which exports lipid A. It may also act in multidrug resistance. Lipid A, a part of lipopolysaccharide, is found in the outer leaflet of the outer membrane of most Gram-negative bacteria. Members of this family are restricted to the Proteobacteria (although lipid A is more broadly distributed) and often are clustered with lipid A biosynthesis genes. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other] Pssm-ID: 131258 [Multi-domain] Cd Length: 571 Bit Score: 106.34 E-value: 2.35e-26
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| PRK11176 | PRK11176 | lipid A ABC transporter ATP-binding protein/permease MsbA; |
1-192 | 4.33e-26 | ||||
lipid A ABC transporter ATP-binding protein/permease MsbA; Pssm-ID: 183016 [Multi-domain] Cd Length: 582 Bit Score: 105.49 E-value: 4.33e-26
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| CydD | TIGR02857 | thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ... |
1-174 | 1.66e-25 | ||||
thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 103.52 E-value: 1.66e-25
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| NHLM_micro_ABC2 | TIGR03797 | NHLM bacteriocin system ABC transporter, ATP-binding protein; Members of this protein family ... |
1-192 | 1.88e-25 | ||||
NHLM bacteriocin system ABC transporter, ATP-binding protein; Members of this protein family are ABC transporter ATP-binding subunits, part of a three-gene putative bacteriocin transport operon. The other subunits include another ATP-binding subunit (TIGR03796), which has an N-terminal leader sequence cleavage domain, and an HlyD homolog (TIGR03794). In a number of genomes, members of protein families related to nitrile hydratase alpha subunit or to nif11 have undergone paralogous family expansions, with members possessing a putative bacteriocin cleavage region ending with a classic Gly-Gly motif. Those sets of putative bacteriocins, members of this protein family and its partners TIGR03794 and TIGR03796, and cyclodehydratase/docking scaffold fusion proteins of thiazole/oxazole biosynthesis frequently show correlated species distribution and co-clustering within many of those genomes. [Transport and binding proteins, Amino acids, peptides and amines, Cellular processes, Biosynthesis of natural products] Pssm-ID: 274789 [Multi-domain] Cd Length: 686 Bit Score: 103.88 E-value: 1.88e-25
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| ATM1 | COG5265 | ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components ... |
1-181 | 1.35e-23 | ||||
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 444078 [Multi-domain] Cd Length: 605 Bit Score: 98.35 E-value: 1.35e-23
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| PRK11174 | PRK11174 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
35-181 | 1.45e-23 | ||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236870 [Multi-domain] Cd Length: 588 Bit Score: 98.38 E-value: 1.45e-23
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| CydC | TIGR02868 | thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family ... |
1-161 | 4.23e-23 | ||||
thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Pssm-ID: 274331 [Multi-domain] Cd Length: 530 Bit Score: 96.66 E-value: 4.23e-23
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| 3a01208 | TIGR00958 | Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other] |
38-193 | 5.85e-23 | ||||
Conjugate Transporter-2 (CT2) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273363 [Multi-domain] Cd Length: 711 Bit Score: 96.71 E-value: 5.85e-23
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| bacteriocin_ABC | TIGR01193 | ABC-type bacteriocin transporter; This model describes ABC-type bacteriocin transporter. The ... |
1-192 | 1.96e-22 | ||||
ABC-type bacteriocin transporter; This model describes ABC-type bacteriocin transporter. The amino terminal domain (pfam03412) processes the N-terminal leader peptide from the bacteriocin while C-terminal domains resemble ABC transporter membrane protein and ATP-binding cassette domain. In general, bacteriocins are agents which are responsible for killing or inhibiting the closely related species or even different strains of the same species. Bacteriocins are usually encoded by bacterial plasmids. Bacteriocins are named after the species and hence in literature one encounters various names e.g., leucocin from Leuconostic geldium; pedicocin from Pedicoccus acidilactici; sakacin from Lactobacillus sake etc. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair, Transport and binding proteins, Other] Pssm-ID: 130261 [Multi-domain] Cd Length: 708 Bit Score: 95.19 E-value: 1.96e-22
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| ABCC_TAP | cd03248 | ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; ... |
40-179 | 2.69e-22 | ||||
ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; TAP (Transporter Associated with Antigen Processing) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. TAP belongs to the large family of ATP-binding cassette (ABC) transporters, which translocate a vast variety of solutes across membranes. Pssm-ID: 213215 [Multi-domain] Cd Length: 226 Bit Score: 90.99 E-value: 2.69e-22
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| PRK13657 | PRK13657 | glucan ABC transporter ATP-binding protein/ permease; |
1-183 | 2.78e-22 | ||||
glucan ABC transporter ATP-binding protein/ permease; Pssm-ID: 184214 [Multi-domain] Cd Length: 588 Bit Score: 94.64 E-value: 2.78e-22
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| ABCC_MRP_domain1 | cd03250 | ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ... |
1-177 | 1.86e-21 | ||||
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 87.91 E-value: 1.86e-21
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| PRK10789 | PRK10789 | SmdA family multidrug ABC transporter permease/ATP-binding protein; |
1-191 | 3.67e-20 | ||||
SmdA family multidrug ABC transporter permease/ATP-binding protein; Pssm-ID: 182732 [Multi-domain] Cd Length: 569 Bit Score: 88.23 E-value: 3.67e-20
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| PTZ00265 | PTZ00265 | multidrug resistance protein (mdr1); Provisional |
37-193 | 4.81e-19 | ||||
multidrug resistance protein (mdr1); Provisional Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 85.47 E-value: 4.81e-19
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| ArpD | COG4618 | ABC-type protease/lipase transport system, ATPase and permease components [Intracellular ... |
49-191 | 1.11e-17 | ||||
ABC-type protease/lipase transport system, ATPase and permease components [Intracellular trafficking, secretion, and vesicular transport]; Pssm-ID: 443660 [Multi-domain] Cd Length: 563 Bit Score: 80.95 E-value: 1.11e-17
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| ABCC_cytochrome_bd | cd03247 | ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ... |
1-181 | 7.73e-16 | ||||
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism. Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 72.35 E-value: 7.73e-16
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| PRK11160 | PRK11160 | cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed |
1-193 | 4.43e-15 | ||||
cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed Pssm-ID: 236865 [Multi-domain] Cd Length: 574 Bit Score: 73.71 E-value: 4.43e-15
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| ABCC_Protease_Secretion | cd03246 | ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ... |
102-179 | 2.05e-14 | ||||
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA. Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 68.40 E-value: 2.05e-14
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| NatA | COG4555 | ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ... |
40-196 | 8.19e-14 | ||||
ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism]; Pssm-ID: 443618 [Multi-domain] Cd Length: 243 Bit Score: 68.35 E-value: 8.19e-14
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| ABC_PstB_phosphate_transporter | cd03260 | ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of ... |
1-188 | 1.03e-13 | ||||
ATP-binding cassette domain of the phosphate transport system; Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein is a phosphate-binding protein located in the periplasmic space. PstA and PstC are hydrophobic and they form the transmembrane portion of the Pst system. PstB is the catalytic subunit, which couples the energy of ATP hydrolysis to the import of phosphate across cellular membranes through the Pst system, often referred as ABC-protein. PstB belongs to one of the largest superfamilies of proteins characterized by a highly conserved adenosine triphosphate (ATP) binding cassette (ABC), which is also a nucleotide binding domain (NBD). Pssm-ID: 213227 [Multi-domain] Cd Length: 227 Bit Score: 67.59 E-value: 1.03e-13
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| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
1-132 | 1.86e-13 | ||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 65.36 E-value: 1.86e-13
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| ABCC_SUR1_N | cd03290 | ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The ... |
1-178 | 3.35e-13 | ||||
ATP-binding cassette domain of the sulfonylurea receptor, subfamily C; The SUR domain 1. The sulfonylurea receptor SUR is an ATP transporter of the ABCC/MRP family with tandem ATPase binding domains. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ATP-sensitive potassium (K(ATP)) channel. Within the channel complex, SUR serves as a regulatory subunit that fine-tunes the gating of Kir6.x in response to alterations in cellular metabolism. It constitutes a major pharmaceutical target as it binds numerous drugs, K(ATP) channel openers and blockers, capable of up- or down-regulating channel activity. Pssm-ID: 213257 [Multi-domain] Cd Length: 218 Bit Score: 66.20 E-value: 3.35e-13
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
1-217 | 6.99e-13 | ||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 66.85 E-value: 6.99e-13
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| PTZ00243 | PTZ00243 | ABC transporter; Provisional |
1-182 | 9.48e-13 | ||||
ABC transporter; Provisional Pssm-ID: 240327 [Multi-domain] Cd Length: 1560 Bit Score: 67.11 E-value: 9.48e-13
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| PTZ00265 | PTZ00265 | multidrug resistance protein (mdr1); Provisional |
1-174 | 1.54e-12 | ||||
multidrug resistance protein (mdr1); Provisional Pssm-ID: 240339 [Multi-domain] Cd Length: 1466 Bit Score: 66.21 E-value: 1.54e-12
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
1-177 | 1.78e-12 | ||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 63.03 E-value: 1.78e-12
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| EcfA2 | COG1122 | Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ... |
1-193 | 6.72e-11 | ||||
Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only]; Pssm-ID: 440739 [Multi-domain] Cd Length: 230 Bit Score: 60.04 E-value: 6.72e-11
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| PLN03232 | PLN03232 | ABC transporter C family member; Provisional |
1-181 | 7.12e-10 | ||||
ABC transporter C family member; Provisional Pssm-ID: 215640 [Multi-domain] Cd Length: 1495 Bit Score: 58.45 E-value: 7.12e-10
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| PRK14247 | PRK14247 | phosphate ABC transporter ATP-binding protein; Provisional |
1-192 | 1.20e-09 | ||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 172735 [Multi-domain] Cd Length: 250 Bit Score: 56.46 E-value: 1.20e-09
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| MRP_assoc_pro | TIGR00957 | multi drug resistance-associated protein (MRP); This model describes multi drug ... |
1-195 | 1.51e-09 | ||||
multi drug resistance-associated protein (MRP); This model describes multi drug resistance-associated protein (MRP) in eukaryotes. The multidrug resistance-associated protein is an integral membrane protein that causes multidrug resistance when overexpressed in mammalian cells. It belongs to ABC transporter superfamily. The protein topology and function was experimentally demonstrated by epitope tagging and immunofluorescence. Insertion of tags in the critical regions associated with drug efflux, abrogated its function. The C-terminal domain seem to highly conserved. [Transport and binding proteins, Other] Pssm-ID: 188098 [Multi-domain] Cd Length: 1522 Bit Score: 57.65 E-value: 1.51e-09
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| ZnuC | COG1121 | ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ... |
105-191 | 2.11e-09 | ||||
ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 55.87 E-value: 2.11e-09
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| ABC_NatA_sodium_exporter | cd03266 | ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a ... |
101-180 | 6.18e-09 | ||||
ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein. Pssm-ID: 213233 [Multi-domain] Cd Length: 218 Bit Score: 54.30 E-value: 6.18e-09
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| FepC | COG1120 | ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion ... |
105-190 | 2.97e-08 | ||||
ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism]; Pssm-ID: 440737 [Multi-domain] Cd Length: 254 Bit Score: 52.74 E-value: 2.97e-08
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| ABC_FtsE | cd03292 | Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ... |
1-165 | 3.80e-08 | ||||
Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 52.02 E-value: 3.80e-08
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| ABC_Metallic_Cations | cd03235 | ATP-binding cassette domain of the metal-type transporters; This family includes transporters ... |
105-179 | 9.04e-08 | ||||
ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates. Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 50.61 E-value: 9.04e-08
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| PRK14267 | PRK14267 | phosphate ABC transporter ATP-binding protein; Provisional |
103-192 | 9.13e-08 | ||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 184596 [Multi-domain] Cd Length: 253 Bit Score: 51.38 E-value: 9.13e-08
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| ABC_Iron-Siderophores_B12_Hemin | cd03214 | ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ... |
105-180 | 1.20e-07 | ||||
ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters. Pssm-ID: 213181 [Multi-domain] Cd Length: 180 Bit Score: 50.13 E-value: 1.20e-07
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| ABC_cobalt_CbiO_domain1 | cd03225 | First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
1-177 | 1.38e-07 | ||||
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 50.16 E-value: 1.38e-07
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| cbiO | PRK13644 | energy-coupling factor transporter ATPase; |
1-199 | 1.78e-07 | ||||
energy-coupling factor transporter ATPase; Pssm-ID: 106587 [Multi-domain] Cd Length: 274 Bit Score: 50.37 E-value: 1.78e-07
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| PRK15134 | PRK15134 | microcin C ABC transporter ATP-binding protein YejF; Provisional |
1-181 | 3.48e-07 | ||||
microcin C ABC transporter ATP-binding protein YejF; Provisional Pssm-ID: 237917 [Multi-domain] Cd Length: 529 Bit Score: 50.09 E-value: 3.48e-07
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| ABC_Class3 | cd03229 | ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ... |
105-177 | 3.54e-07 | ||||
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 48.72 E-value: 3.54e-07
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| ABCC_CFTR1 | cd03291 | ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The ... |
1-178 | 3.57e-07 | ||||
ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C; The CFTR subfamily domain 1. The cystic fibrosis transmembrane regulator (CFTR), the product of the gene mutated in patients with cystic fibrosis, has adapted the ABC transporter structural motif to form a tightly regulated anion channel at the apical surface of many epithelia. Use of the term assembly of a functional ion channel implies the coming together of subunits, or at least smaller not-yet functional components of the active whole. In fact, on the basis of current knowledge only the CFTR polypeptide itself is required to form an ATP- and protein kinase A-dependent low-conductance chloride channel of the type present in the apical membrane of many epithelial cells. CFTR displays the typical organization (IM-ABC)2 and carries a characteristic hydrophilic R-domain that separates IM1-ABC1 from IM2-ABC2. Pssm-ID: 213258 [Multi-domain] Cd Length: 282 Bit Score: 49.47 E-value: 3.57e-07
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| ABC_NikE_OppD_transporters | cd03257 | ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ... |
1-182 | 4.50e-07 | ||||
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF. Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 49.04 E-value: 4.50e-07
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| YejF | COG4172 | ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites ... |
1-186 | 5.17e-07 | ||||
ABC-type microcin C transport system, duplicated ATPase component YejF [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 443332 [Multi-domain] Cd Length: 533 Bit Score: 49.68 E-value: 5.17e-07
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| YddA | COG4178 | ABC-type uncharacterized transport system, permease and ATPase components [General function ... |
49-161 | 5.67e-07 | ||||
ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Pssm-ID: 443337 [Multi-domain] Cd Length: 571 Bit Score: 49.42 E-value: 5.67e-07
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
104-191 | 7.09e-07 | ||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 49.13 E-value: 7.09e-07
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| ABC_DR_subfamily_A | cd03230 | ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ... |
100-177 | 7.50e-07 | ||||
ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213197 [Multi-domain] Cd Length: 173 Bit Score: 47.78 E-value: 7.50e-07
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| cbiO | PRK13632 | cobalt transporter ATP-binding subunit; Provisional |
1-193 | 8.07e-07 | ||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237452 [Multi-domain] Cd Length: 271 Bit Score: 48.45 E-value: 8.07e-07
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| ABC_ThiQ_thiamine_transporter | cd03298 | ATP-binding cassette domain of the thiamine transport system; Part of the ... |
92-179 | 1.09e-06 | ||||
ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213265 [Multi-domain] Cd Length: 211 Bit Score: 47.87 E-value: 1.09e-06
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| cbiO | PRK13640 | energy-coupling factor transporter ATPase; |
1-191 | 1.16e-06 | ||||
energy-coupling factor transporter ATPase; Pssm-ID: 184200 [Multi-domain] Cd Length: 282 Bit Score: 48.26 E-value: 1.16e-06
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| ABCD_peroxisomal_ALDP | cd03223 | ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding ... |
89-161 | 1.33e-06 | ||||
ATP-binding cassette domain of peroxisomal transporter, subfamily D; Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed during fatty acid beta-oxidation. To communicate with the cytoplasm and mitochondria, peroxisomes need dedicated proteins to transport such hydrophilic molecules across their membranes. X-linked adrenoleukodystrophy (X-ALD) is caused by mutations in the ALD gene, which encodes ALDP (adrenoleukodystrophy protein ), a peroxisomal integral membrane protein that is a member of the ATP-binding cassette (ABC) transporter protein family. The disease is characterized by a striking and unpredictable variation in phenotypic expression. Phenotypes include the rapidly progressive childhood cerebral form (CCALD), the milder adult form, adrenomyeloneuropathy (AMN), and variants without neurologic involvement (i.e. asymptomatic). Pssm-ID: 213190 [Multi-domain] Cd Length: 166 Bit Score: 46.76 E-value: 1.33e-06
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| ABC_Carb_Monos_I | cd03216 | First domain of the ATP-binding cassette component of monosaccharide transport system; This ... |
105-179 | 2.22e-06 | ||||
First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter. Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 46.27 E-value: 2.22e-06
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| PLN03130 | PLN03130 | ABC transporter C family member; Provisional |
39-181 | 2.24e-06 | ||||
ABC transporter C family member; Provisional Pssm-ID: 215595 [Multi-domain] Cd Length: 1622 Bit Score: 47.81 E-value: 2.24e-06
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| PRK14271 | PRK14271 | phosphate ABC transporter ATP-binding protein; Provisional |
1-190 | 6.56e-06 | ||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 172759 [Multi-domain] Cd Length: 276 Bit Score: 45.86 E-value: 6.56e-06
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| CFTR_protein | TIGR01271 | cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis ... |
1-177 | 7.74e-06 | ||||
cystic fibrosis transmembrane conductor regulator (CFTR); The model describes the cystis fibrosis transmembrane conductor regulator (CFTR) in eukaryotes. The principal role of this protein is chloride ion conductance. The protein is predicted to consist of 12 transmembrane domains. Mutations or lesions in the genetic loci have been linked to the aetiology of asthma, bronchiectasis, chronic obstructive pulmonary disease etc. Disease-causing mutations have been studied by 36Cl efflux assays in vitro cell cultures and electrophysiology, all of which point to the impairment of chloride channel stability and not the biosynthetic processing per se. [Transport and binding proteins, Anions] Pssm-ID: 273530 [Multi-domain] Cd Length: 1490 Bit Score: 46.44 E-value: 7.74e-06
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| CcmA | COG4133 | ABC-type transport system involved in cytochrome c biogenesis, ATPase component ... |
68-160 | 9.22e-06 | ||||
ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 44.78 E-value: 9.22e-06
|
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| PRK14258 | PRK14258 | phosphate ABC transporter ATP-binding protein; Provisional |
34-211 | 1.21e-05 | ||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 184593 [Multi-domain] Cd Length: 261 Bit Score: 45.03 E-value: 1.21e-05
|
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| DppF | COG1124 | ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid ... |
105-190 | 1.35e-05 | ||||
ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism, Inorganic ion transport and metabolism]; Pssm-ID: 440741 [Multi-domain] Cd Length: 248 Bit Score: 44.79 E-value: 1.35e-05
|
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| PRK10261 | PRK10261 | glutathione transporter ATP-binding protein; Provisional |
1-181 | 1.44e-05 | ||||
glutathione transporter ATP-binding protein; Provisional Pssm-ID: 182342 [Multi-domain] Cd Length: 623 Bit Score: 45.23 E-value: 1.44e-05
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| ABC_ModC_like | cd03299 | ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely ... |
102-190 | 1.75e-05 | ||||
ATP-binding cassette domain similar to the molybdate transporter; Archaeal protein closely related to ModC. ModC is an ABC-type transporter and the ATPase component of a molybdate transport system that also includes the periplasmic binding protein ModA and the membrane protein ModB. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213266 [Multi-domain] Cd Length: 235 Bit Score: 44.25 E-value: 1.75e-05
|
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| potA | TIGR01187 | spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine ... |
75-191 | 2.10e-05 | ||||
spermidine/putrescine ABC transporter ATP-binding subunit; This model describes spermidine/putrescine ABC transporter, ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporter is the obligatory coupling of ATP hydrolysis to substrate translocation. The minimal configuration of bacterial ABC transport system: an ATPase or ATP binding subunit; An integral membrane protein; a hydrophilic polypetpide, which likely functions as substrate binding protein. Polyamines like spermidine and putrescine play vital role in cell proliferation, differentiation, and ion homeostasis. The concentration of polyamines within the cell are regulated by biosynthesis, degradation and transport (uptake and efflux included). [Transport and binding proteins, Amino acids, peptides and amines] Pssm-ID: 162242 [Multi-domain] Cd Length: 325 Bit Score: 44.41 E-value: 2.10e-05
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| PRK14246 | PRK14246 | phosphate ABC transporter ATP-binding protein; Provisional |
104-192 | 2.28e-05 | ||||
phosphate ABC transporter ATP-binding protein; Provisional Pssm-ID: 172734 [Multi-domain] Cd Length: 257 Bit Score: 44.27 E-value: 2.28e-05
|
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| PRK10070 | PRK10070 | proline/glycine betaine ABC transporter ATP-binding protein ProV; |
1-190 | 2.39e-05 | ||||
proline/glycine betaine ABC transporter ATP-binding protein ProV; Pssm-ID: 182221 [Multi-domain] Cd Length: 400 Bit Score: 44.64 E-value: 2.39e-05
|
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| btuD | PRK09536 | corrinoid ABC transporter ATPase; Reviewed |
105-190 | 4.22e-05 | ||||
corrinoid ABC transporter ATPase; Reviewed Pssm-ID: 236554 [Multi-domain] Cd Length: 402 Bit Score: 43.68 E-value: 4.22e-05
|
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| ModF | COG1119 | ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA ... |
105-189 | 4.28e-05 | ||||
ABC-type molybdenum transport system, ATPase component ModF/photorepair protein PhrA [Inorganic ion transport and metabolism]; Pssm-ID: 440736 [Multi-domain] Cd Length: 250 Bit Score: 43.15 E-value: 4.28e-05
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| ABC_NrtD_SsuB_transporters | cd03293 | ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ... |
1-170 | 4.30e-05 | ||||
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 43.23 E-value: 4.30e-05
|
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| ABC_Carb_Solutes_like | cd03259 | ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ... |
1-183 | 4.46e-05 | ||||
ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213226 [Multi-domain] Cd Length: 213 Bit Score: 42.89 E-value: 4.46e-05
|
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| cbiO | PRK13638 | energy-coupling factor ABC transporter ATP-binding protein; |
104-190 | 5.79e-05 | ||||
energy-coupling factor ABC transporter ATP-binding protein; Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 43.07 E-value: 5.79e-05
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| ABCG_EPDR | cd03213 | Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ... |
1-177 | 6.30e-05 | ||||
Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus. Pssm-ID: 213180 [Multi-domain] Cd Length: 194 Bit Score: 42.54 E-value: 6.30e-05
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| ABC_PhnC_transporter | cd03256 | ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ... |
105-185 | 1.01e-04 | ||||
ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 42.17 E-value: 1.01e-04
|
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| cbiO | PRK13648 | cobalt transporter ATP-binding subunit; Provisional |
105-194 | 1.55e-04 | ||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 41.66 E-value: 1.55e-04
|
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| met_CoM_red_A2 | TIGR03269 | methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ... |
78-191 | 2.46e-04 | ||||
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis] Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 41.71 E-value: 2.46e-04
|
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| cbiO | PRK13641 | energy-coupling factor transporter ATPase; |
1-193 | 2.73e-04 | ||||
energy-coupling factor transporter ATPase; Pssm-ID: 237456 [Multi-domain] Cd Length: 287 Bit Score: 40.97 E-value: 2.73e-04
|
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| met_CoM_red_A2 | TIGR03269 | methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in ... |
40-190 | 3.01e-04 | ||||
methyl coenzyme M reductase system, component A2; The enzyme that catalyzes the final step in methanogenesis, methyl coenzyme M reductase, contains alpha, beta, and gamma chains. In older literature, the complex of alpha, beta, and gamma chains was termed component C, while this single chain protein was termed methyl coenzyme M reductase system component A2. [Energy metabolism, Methanogenesis] Pssm-ID: 132313 [Multi-domain] Cd Length: 520 Bit Score: 41.33 E-value: 3.01e-04
|
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| MalK | COG3839 | ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; ... |
105-188 | 3.80e-04 | ||||
ABC-type sugar transport system, ATPase component MalK [Carbohydrate transport and metabolism]; Pssm-ID: 443050 [Multi-domain] Cd Length: 352 Bit Score: 40.83 E-value: 3.80e-04
|
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| cbiO | PRK13635 | energy-coupling factor ABC transporter ATP-binding protein; |
105-191 | 4.12e-04 | ||||
energy-coupling factor ABC transporter ATP-binding protein; Pssm-ID: 184195 [Multi-domain] Cd Length: 279 Bit Score: 40.38 E-value: 4.12e-04
|
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| PLN03140 | PLN03140 | ABC transporter G family member; Provisional |
75-177 | 6.13e-04 | ||||
ABC transporter G family member; Provisional Pssm-ID: 215599 [Multi-domain] Cd Length: 1470 Bit Score: 40.60 E-value: 6.13e-04
|
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| ABC_Pro_Gly_Betaine | cd03294 | ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This ... |
75-189 | 7.15e-04 | ||||
ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these transporters is the obligatory coupling of ATP hydrolysis to substrate translocation. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213261 [Multi-domain] Cd Length: 269 Bit Score: 39.55 E-value: 7.15e-04
|
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| cbiO | PRK13650 | energy-coupling factor transporter ATPase; |
105-193 | 7.72e-04 | ||||
energy-coupling factor transporter ATPase; Pssm-ID: 184209 [Multi-domain] Cd Length: 279 Bit Score: 39.71 E-value: 7.72e-04
|
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| ABC_MetN_methionine_transporter | cd03258 | ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ... |
103-191 | 8.06e-04 | ||||
ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213225 [Multi-domain] Cd Length: 233 Bit Score: 39.49 E-value: 8.06e-04
|
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| ABC_OpuCA_Osmoprotection | cd03295 | ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding ... |
105-189 | 1.14e-03 | ||||
ATP-binding cassette domain of the osmoprotectant transporter; OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition, to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213262 [Multi-domain] Cd Length: 242 Bit Score: 38.82 E-value: 1.14e-03
|
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| ABC_NatA_like | cd03267 | ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; ... |
103-180 | 1.20e-03 | ||||
ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein. Pssm-ID: 213234 [Multi-domain] Cd Length: 236 Bit Score: 38.85 E-value: 1.20e-03
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| ABC_TM1139_LivF_branched | cd03224 | ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ... |
101-190 | 1.31e-03 | ||||
ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 38.57 E-value: 1.31e-03
|
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| cbiO | PRK13642 | energy-coupling factor transporter ATPase; |
1-193 | 1.80e-03 | ||||
energy-coupling factor transporter ATPase; Pssm-ID: 184202 [Multi-domain] Cd Length: 277 Bit Score: 38.54 E-value: 1.80e-03
|
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| ABC_Mj1267_LivG_branched | cd03219 | ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ... |
92-180 | 2.27e-03 | ||||
ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 38.19 E-value: 2.27e-03
|
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| ABC_CcmA_heme_exporter | cd03231 | Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ... |
68-151 | 2.64e-03 | ||||
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE. Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 37.86 E-value: 2.64e-03
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| PRK14243 | PRK14243 | phosphate transporter ATP-binding protein; Provisional |
1-188 | 3.00e-03 | ||||
phosphate transporter ATP-binding protein; Provisional Pssm-ID: 184588 [Multi-domain] Cd Length: 264 Bit Score: 37.84 E-value: 3.00e-03
|
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| thiQ | PRK10771 | thiamine ABC transporter ATP-binding protein ThiQ; |
44-137 | 4.24e-03 | ||||
thiamine ABC transporter ATP-binding protein ThiQ; Pssm-ID: 182716 [Multi-domain] Cd Length: 232 Bit Score: 37.25 E-value: 4.24e-03
|
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| cbiO | PRK13647 | cobalt transporter ATP-binding subunit; Provisional |
1-193 | 5.07e-03 | ||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 237457 [Multi-domain] Cd Length: 274 Bit Score: 37.02 E-value: 5.07e-03
|
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| PLN03211 | PLN03211 | ABC transporter G-25; Provisional |
105-184 | 5.43e-03 | ||||
ABC transporter G-25; Provisional Pssm-ID: 215634 [Multi-domain] Cd Length: 659 Bit Score: 37.55 E-value: 5.43e-03
|
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| AAA | smart00382 | ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
96-186 | 6.14e-03 | ||||
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment. Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 36.20 E-value: 6.14e-03
|
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| ThiQ | COG3840 | ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism]; |
105-137 | 6.19e-03 | ||||
ABC-type thiamine transport system, ATPase component ThiQ [Coenzyme transport and metabolism]; Pssm-ID: 443051 [Multi-domain] Cd Length: 232 Bit Score: 36.66 E-value: 6.19e-03
|
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| MglA | COG1129 | ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; |
102-135 | 7.06e-03 | ||||
ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Pssm-ID: 440745 [Multi-domain] Cd Length: 497 Bit Score: 36.92 E-value: 7.06e-03
|
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| ABC_Org_Solvent_Resistant | cd03261 | ATP-binding cassette transport system involved in resistance to organic solvents; ABC ... |
29-197 | 7.38e-03 | ||||
ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 36.33 E-value: 7.38e-03
|
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| PRK15112 | PRK15112 | peptide ABC transporter ATP-binding protein SapF; |
104-137 | 7.58e-03 | ||||
peptide ABC transporter ATP-binding protein SapF; Pssm-ID: 185067 [Multi-domain] Cd Length: 267 Bit Score: 36.69 E-value: 7.58e-03
|
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| rim_protein | TIGR01257 | retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim ... |
78-177 | 7.78e-03 | ||||
retinal-specific rim ABC transporter; This model describes the photoreceptor protein (rim protein) in eukaryotes. It is the member of ABC transporter superfamily. Rim protein is a membrane glycoprotein which is localized in the photoreceptor outer segment discs. Mutation/s in its genetic loci is implicated in the recessive Stargardt's disease. [Transport and binding proteins, Other] Pssm-ID: 130324 [Multi-domain] Cd Length: 2272 Bit Score: 37.30 E-value: 7.78e-03
|
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| Blast search parameters | ||||
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