Chain A, FIBROBLAST GROWTH FACTOR 7
fibroblast growth factor( domain architecture ID 11269561)
fibroblast growth factor (FGF) is a mitogen, which stimulates growth or differentiation of cells of mesodermal or neuroectodermal origin
List of domain hits
Name | Accession | Description | Interval | E-value | |||
FGF | smart00442 | Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or ... |
9-137 | 2.78e-55 | |||
Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities. : Pssm-ID: 214665 Cd Length: 126 Bit Score: 168.98 E-value: 2.78e-55
|
|||||||
Name | Accession | Description | Interval | E-value | |||
FGF | smart00442 | Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or ... |
9-137 | 2.78e-55 | |||
Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities. Pssm-ID: 214665 Cd Length: 126 Bit Score: 168.98 E-value: 2.78e-55
|
|||||||
FGF | pfam00167 | Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in ... |
11-135 | 6.99e-55 | |||
Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms. Pssm-ID: 425498 Cd Length: 124 Bit Score: 168.11 E-value: 6.99e-55
|
|||||||
FGF | cd00058 | Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or ... |
13-137 | 3.13e-50 | |||
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate embryogenesis, and has neurotrophic activities. FGFs have a high affinity for heparan sulfate proteoglycans and require heparan sulfate to activate one of four cell surface FGF receptors. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active. FGFs have internal pseudo-threefold symmetry (beta-trefoil topology). Pssm-ID: 238015 Cd Length: 123 Bit Score: 156.23 E-value: 3.13e-50
|
|||||||
Name | Accession | Description | Interval | E-value | |||
FGF | smart00442 | Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or ... |
9-137 | 2.78e-55 | |||
Acidic and basic fibroblast growth factor family; Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities. Pssm-ID: 214665 Cd Length: 126 Bit Score: 168.98 E-value: 2.78e-55
|
|||||||
FGF | pfam00167 | Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in ... |
11-135 | 6.99e-55 | |||
Fibroblast growth factor; Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms. Pssm-ID: 425498 Cd Length: 124 Bit Score: 168.11 E-value: 6.99e-55
|
|||||||
FGF | cd00058 | Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or ... |
13-137 | 3.13e-50 | |||
Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate embryogenesis, and has neurotrophic activities. FGFs have a high affinity for heparan sulfate proteoglycans and require heparan sulfate to activate one of four cell surface FGF receptors. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active. FGFs have internal pseudo-threefold symmetry (beta-trefoil topology). Pssm-ID: 238015 Cd Length: 123 Bit Score: 156.23 E-value: 3.13e-50
|
|||||||
Blast search parameters | ||||
|