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Conserved domains on  [gi|6980817]
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Chain D, FIBRINOGEN (ALPHA CHAIN)

Protein Classification

Fib_alpha and dermokine domain-containing protein( domain architecture ID 10554870)

Fib_alpha and dermokine domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 33-174 9.61e-63

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


:

Pssm-ID: 462570  Cd Length: 143  Bit Score: 197.76  E-value: 9.61e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817     33 ETGWPFCSDEDWNTKCPSGCRMKGLIDEVDQDFTSRINKLRDSLFNYQKNSKDSNTLTKNIVELMRGDFAKANNNDNTFK 112
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6980817    113 QINEDLRSRIEILRRKVIEQVQRINLLQKNVRDQLVDMKRLEVDIDIKIRSCKGSCSRALEH 174
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEI 142
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 250-385 2.76e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817    250 GDGHARGDSVSQGTGLAPGSP-----RKPGTSSIGNVNPGSYGPGSSGTWNPGRPEPG---------SAGTWNPGRPEPG 315
Cdd:PHA03307  204 PRPPRRSSPISASASSPAPAPgrsaaDDAGASSSDSSSSESSGCGWGPENECPLPRPApitlptriwEASGWNGPSSRPG 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817    316 SAGtwnPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEPGSAGTWNTGSSGSSSFRPDSSGHGNIRPSSPD 385
Cdd:PHA03307  284 PAS---SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRS 350
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 33-174 9.61e-63

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 197.76  E-value: 9.61e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817     33 ETGWPFCSDEDWNTKCPSGCRMKGLIDEVDQDFTSRINKLRDSLFNYQKNSKDSNTLTKNIVELMRGDFAKANNNDNTFK 112
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6980817    113 QINEDLRSRIEILRRKVIEQVQRINLLQKNVRDQLVDMKRLEVDIDIKIRSCKGSCSRALEH 174
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEI 142
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 250-385 2.76e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817    250 GDGHARGDSVSQGTGLAPGSP-----RKPGTSSIGNVNPGSYGPGSSGTWNPGRPEPG---------SAGTWNPGRPEPG 315
Cdd:PHA03307  204 PRPPRRSSPISASASSPAPAPgrsaaDDAGASSSDSSSSESSGCGWGPENECPLPRPApitlptriwEASGWNGPSSRPG 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817    316 SAGtwnPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEPGSAGTWNTGSSGSSSFRPDSSGHGNIRPSSPD 385
Cdd:PHA03307  284 PAS---SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRS 350
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 67-187 1.78e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817     67 SRINKLRDSLFNYQKNSKDSNTLTKNIVELMRgdfaKANNNDNTFKQINEDLRSRIEILrRKVIEQVQRINLLQKNVRDQ 146
Cdd:TIGR04523 194 NKLLKLELLLSNLKKKIQKNKSLESQISELKK----QNNQLKDNIEKKQQEINEKTTEI-SNTQTQLNQLKDEQNKIKKQ 268

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 6980817    147 LVDmKRLEVD-IDIKIRSCKGSCSralEHKVDLEDYKNQQKQ 187
Cdd:TIGR04523 269 LSE-KQKELEqNNKKIKELEKQLN---QLKSEISDLNNQKEQ 306
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 249-387 1.79e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 40.37  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817  249 GGDGHARGDSVSQGTGLAPGSPRKPGTS-SIGNVNPGSYGPGSSGTWNPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEP 327
Cdd:cd21118 188 PGYGTVRGNNQNSGCTNPPPSGSHESFSnSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNSGGSNG 267

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817  328 GSAGtwNPGRPEPGSagtwnpgrpepGSAGTWNTGSSGSSSFRPdSSGHGNirpsSPDWG 387
Cdd:cd21118 268 GSSG--NSGSGSGGS-----------SSGGSNGWGGSSSSGGSG-GSGGGN----KPECN 309
 
Name Accession Description Interval E-value
Fib_alpha pfam08702
Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation ...
 33-174 9.61e-63

Fibrinogen alpha/beta chain family; Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood. This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).


Pssm-ID: 462570  Cd Length: 143  Bit Score: 197.76  E-value: 9.61e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817     33 ETGWPFCSDEDWNTKCPSGCRMKGLIDEVDQDFTSRINKLRDSLFNYQKNSKDSNTLTKNIVELMRGDFAKANNNDNTFK 112
Cdd:pfam08702   1 DKGGCCHADEDFGVLCPTGCGIQDLLLKYERDVDKDLQKLENLLDQISNSTSSADELVKQIKDSLRERQKSSPDNDNVYN 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6980817    113 QINEDLRSRIEILRRKVIEQVQRINLLQKNVRDQLVDMKRLEVDIDIKIRSCKGSCSRALEH 174
Cdd:pfam08702  81 KSSSMLEERIAYIKETVDTQESNIRVLQNILDSNRQKIQRLEQDIDQLERKCKEPCKDSVEI 142
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 250-385 2.76e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817    250 GDGHARGDSVSQGTGLAPGSP-----RKPGTSSIGNVNPGSYGPGSSGTWNPGRPEPG---------SAGTWNPGRPEPG 315
Cdd:PHA03307  204 PRPPRRSSPISASASSPAPAPgrsaaDDAGASSSDSSSSESSGCGWGPENECPLPRPApitlptriwEASGWNGPSSRPG 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817    316 SAGtwnPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEPGSAGTWNTGSSGSSSFRPDSSGHGNIRPSSPD 385
Cdd:PHA03307  284 PAS---SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRS 350
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 249-359 1.17e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 44.29  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817   249 GGDGHARGDSVSQGTGLAPGSPRKPGTSSIGNVNPGSYGPGSSG---------TWNPGRPEPGSAGTwnPGRPEPGSAGT 319
Cdd:PRK14959 382 SGSAAEGPASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPApsaapsprvPWDDAPPAPPRSGI--PPRPAPRMPEA 459

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 6980817   320 WN-PGRPEPGSAGTWNPgrPEPGSAGtwNPGRPEPGSAGTW 359
Cdd:PRK14959 460 SPvPGAPDSVASASDAP--PTLGDPS--DTAEHTPSGPRTW 496
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 67-187 1.78e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.47  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817     67 SRINKLRDSLFNYQKNSKDSNTLTKNIVELMRgdfaKANNNDNTFKQINEDLRSRIEILrRKVIEQVQRINLLQKNVRDQ 146
Cdd:TIGR04523 194 NKLLKLELLLSNLKKKIQKNKSLESQISELKK----QNNQLKDNIEKKQQEINEKTTEI-SNTQTQLNQLKDEQNKIKKQ 268

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 6980817    147 LVDmKRLEVD-IDIKIRSCKGSCSralEHKVDLEDYKNQQKQ 187
Cdd:TIGR04523 269 LSE-KQKELEqNNKKIKELEKQLN---QLKSEISDLNNQKEQ 306
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 249-387 1.79e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 40.37  E-value: 1.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817  249 GGDGHARGDSVSQGTGLAPGSPRKPGTS-SIGNVNPGSYGPGSSGTWNPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEP 327
Cdd:cd21118 188 PGYGTVRGNNQNSGCTNPPPSGSHESFSnSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNSGGSNG 267

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817  328 GSAGtwNPGRPEPGSagtwnpgrpepGSAGTWNTGSSGSSSFRPdSSGHGNirpsSPDWG 387
Cdd:cd21118 268 GSSG--NSGSGSGGS-----------SSGGSNGWGGSSSSGGSG-GSGGGN----KPECN 309
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 246-377 1.86e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 40.37  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817  246 ETFGGDGHARGDSVSQGTGLAPGSPRKPGTSSIGNVNPGSYGPGSSGTWNPGRPEPGSAGTWNPGRPEPGSAGTWNPGrP 325
Cdd:cd21118 212 ESFSNSGGSSSSGSSGSQGSHGSNGQGSSGSSGGQGNGGNNGSSSSNSGNSGGSNGGSSGNSGSGSGGSSSGGSNGWG-G 290

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6980817  326 EPGSAgtwnpGRPEPGSAGTWNPGRPEPGSAgtwNTGSSGSSSFRPDSSGHG 377
Cdd:cd21118 291 SSSSG-----GSGGSGGGNKPECNNPGNDVR---MAGGGGSQGSKESSGSHG 334
dermokine cd21118
dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a ...
 254-384 5.34e-03

dermokine; Dermokine, also known as epidermis-specific secreted protein SK30/SK89, is a skin-specific glycoprotein that may play a regulatory role in the crosstalk between barrier dysfunction and inflammation, and therefore play a role in inflammatory diseases such as psoriasis. Dermokine is one of the most highly expressed proteins in differentiating keratinocytes, found mainly in the spinous and granular layers of the epidermis, but also in the epithelia of the small intestine, macrophages of the lung, and endothelial cells of the lung. Mouse dermokine has been reported to be encoded by 22 exons, and its expression leads to alpha, beta, and gamma transcripts.


Pssm-ID: 411053 [Multi-domain]  Cd Length: 495  Bit Score: 38.83  E-value: 5.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817  254 ARGDSVSQGtglAPGSPRKPGTSSIGNVNPGSYGPGSSGTWNPGRPEPGSAGTWNPGRPEPGSAGTWNPGRPEP-GSAGT 332
Cdd:cd21118 161 SLGGSVGQG---GNGGPLNYGTNSQGAVAQPGYGTVRGNNQNSGCTNPPPSGSHESFSNSGGSSSSGSSGSQGShGSNGQ 237

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6980817  333 WNPGRPEPGSAGTWNPG-RPEPGSAGTWNTGSSGSSSFRPDSSGHGNIRPSSP 384
Cdd:cd21118 238 GSSGSSGGQGNGGNNGSsSSNSGNSGGSNGGSSGNSGSGSGGSSSGGSNGWGG 290
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 266-385 8.83e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.23  E-value: 8.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6980817    266 APGSPRKPGTSSIGNVNPGSYGPGSSGTWNPGRPEPGSAGTWNPGRPEPGSAGTwnPGRPePGSAGTWNPGRPEPGSAGT 345
Cdd:PHA03307  299 SPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPS--PSRP-PPPADPSSPRKRPRPSRAP 375

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6980817    346 WNP----GRPEPGSAGtWNTGSSGSSSFRPDSSGHGNIRPSSPD 385
Cdd:PHA03307  376 SSPaasaGRPTRRRAR-AAVAGRARRRDATGRFPAGRPRPSPLD 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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