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Conserved domains on  [gi|72085956|ref|XP_792838|]
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COMM domain-containing protein 5 [Strongylocentrotus purpuratus]

Protein Classification

COMM domain-containing protein 5( domain architecture ID 10140833)

COMM domain-containing protein 5 (COMMD5) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and negatively regulates cell proliferation.

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 111-220 9.73e-63

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240101  Cd Length: 110  Bit Score: 190.73  E-value: 9.73e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72085956 111 ELKIPPEYATDFASAVYGPKRAAINDALEKGRVRFPKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSDGKVHSFEIPV 190
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 72085956 191 SKFHELRYNVASLMKEMEDLEKKNILKIQD 220
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 111-220 9.73e-63

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 190.73  E-value: 9.73e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72085956 111 ELKIPPEYATDFASAVYGPKRAAINDALEKGRVRFPKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSDGKVHSFEIPV 190
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 72085956 191 SKFHELRYNVASLMKEMEDLEKKNILKIQD 220
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 144-202 1.77e-13

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 62.95  E-value: 1.77e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72085956   144 RFPKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSDG----KVHSFEIPVSKFHELRYNVAS 202
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdgssEEVTFELSKEQLQDLLNELEE 63
 
Name Accession Description Interval E-value
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 111-220 9.73e-63

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 190.73  E-value: 9.73e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72085956 111 ELKIPPEYATDFASAVYGPKRAAINDALEKGRVRFPKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSDGKVHSFEIPV 190
Cdd:cd04753   1 ELRIPEELITDLASVVYGQRRPLLESGALQKGVRLPHLEDFKWRVDVAISTSSLSRVLQPSILMEMKLSDGKSHRFEVPV 80

                        90       100       110
                ....*....|....*....|....*....|
gi 72085956 191 SKFHELRYNVASLMKEMEDLEKKNILKIQD 220
Cdd:cd04753  81 AKFHELRYNVALILKEMNDLEKRSILKIQD 110
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 144-202 1.77e-13

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 62.95  E-value: 1.77e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72085956   144 RFPKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSDG----KVHSFEIPVSKFHELRYNVAS 202
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGdgssEEVTFELSKEQLQDLLNELEE 63
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 146-220 2.96e-08

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 49.61  E-value: 2.96e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 72085956 146 PKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSDGKVHSFEipvskfhELRYNVASLMKEMeDLEKKNILKIQD 220
Cdd:cd04748  21 PQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSE-------KICFEMTKEELQN-FLNKLKKIKAQL 87
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 91-210 3.03e-08

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 51.66  E-value: 3.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72085956  91 AAYRLPQTSLKQELfkadlSELKIPPEYATDFASAvYGPKRAAINDALEKGRVRFPKLDNFRWRVDVAISTSALSRSLEP 170
Cdd:cd04752  56 AKYNVDGESLSSEL-----QQLGLPKEHATSLCRS-YEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQEVNEP 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 72085956 171 TIMAEMTLSDG-----KVHSFEIPVSKFHELRYNVASLMKEMEDL 210
Cdd:cd04752 130 LVQLRLKVRNAdtgeiTPHPFSVSADKFRVLLAELKQAQTLMETL 174
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 105-212 6.18e-03

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 36.14  E-value: 6.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72085956 105 FKADLSELKIPPEYATDFaSAVYGPKRAAINDALEKGRVRFPKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSDGKVH 184
Cdd:cd04750  57 FQDSIEFLGFSDDLNEIL-LQLYESNRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLEDENKK 135

                        90       100
                ....*....|....*....|....*...
gi 72085956 185 SFEipvskfHELRYNVASLMKEMEDLEK 212
Cdd:cd04750 136 IET------HLLQTDPANLVHLTQTLEQ 157
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 134-180 8.66e-03

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 34.85  E-value: 8.66e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 72085956 134 INDALEKgRVRFPKLDNFRWRVDVAISTSALSRSLEPTIMAEMTLSD 180
Cdd:cd04757  21 RSEASEN-QISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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