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Conserved domains on  [gi|73853878|ref|NP_001027524|]
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T-box transcription factor TBX3 [Xenopus tropicalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 105-286 1.94e-155

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


:

Pssm-ID: 410314  Cd Length: 185  Bit Score: 446.88  E-value: 1.94e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20188   4 KVELEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTA 264
Cdd:cd20188  84 MYIHPDSPSTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFKETEFIAVTA 163

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20188 164 YQNEKITQLKIDNNPFAKGFRD 185
TBX super family cl13973
T-box transcription factor; This domain family is found in eukaryotes, and is typically ...
 304-381 2.58e-14

T-box transcription factor; This domain family is found in eukaryotes, and is typically between 77 and 89 amino acids in length. The family is found in association with pfam00907. There are two completely conserved residues (S and P) that may be functionally important. T-box genes encode transcription factors involved in morphogenesis and organogenesis of vertebrates and invertebrates


The actual alignment was detected with superfamily member pfam12598:

Pssm-ID: 432659  Cd Length: 81  Bit Score: 68.65  E-value: 2.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878   304 RPYDDH--QKKDNGSSDESSSEQTAYKcfAQTSSPTAPAVgtSSLKGVPPSDGESDEESRDEGGPDTGESTKISTTTSED 381
Cdd:pfam12598   1 RMYEEQckQDRDGGTSDASSGEPTAGR--DQAHSPAVPAV--SPLKFHRPSREDSKTCADSDDELDQEDSGKISTTTTES 76
 
Name Accession Description Interval E-value
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 105-286 1.94e-155

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 446.88  E-value: 1.94e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20188   4 KVELEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTA 264
Cdd:cd20188  84 MYIHPDSPSTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFKETEFIAVTA 163

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20188 164 YQNEKITQLKIDNNPFAKGFRD 185
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 106-286 4.19e-131

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 384.60  E-value: 4.19e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878   106 VHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRM 185
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVVAGKAEPHSPPRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878   186 YIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR-ANDILKLPYSTFRTYVFPETEFIAVTA 264
Cdd:pfam00907  81 YIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRvGGDEPSLPEENVKTFVFPETEFIAVTA 160

                         170       180
                  ....*....|....*....|..
gi 73853878   265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:pfam00907 161 YQNEEITQLKIDNNPFAKGFRD 182
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
105-291 4.73e-116

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 346.18  E-value: 4.73e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878    105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:smart00425   2 KVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGKAEPHMPSR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878    185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFT--ILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAV 262
Cdd:smart00425  82 VYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHLqiILNSMHKYQPRLHIVEVDDISKEILSQFKTFVFPETQFIAV 161

                          170       180
                   ....*....|....*....|....*....
gi 73853878    263 TAYQNDKITQLKIDNNPFAKGFRDTGNGR 291
Cdd:smart00425 162 TAYQNQKITKLKIDNNPFAKGFRDQGRRR 190
TBX pfam12598
T-box transcription factor; This domain family is found in eukaryotes, and is typically ...
 304-381 2.58e-14

T-box transcription factor; This domain family is found in eukaryotes, and is typically between 77 and 89 amino acids in length. The family is found in association with pfam00907. There are two completely conserved residues (S and P) that may be functionally important. T-box genes encode transcription factors involved in morphogenesis and organogenesis of vertebrates and invertebrates


Pssm-ID: 432659  Cd Length: 81  Bit Score: 68.65  E-value: 2.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878   304 RPYDDH--QKKDNGSSDESSSEQTAYKcfAQTSSPTAPAVgtSSLKGVPPSDGESDEESRDEGGPDTGESTKISTTTSED 381
Cdd:pfam12598   1 RMYEEQckQDRDGGTSDASSGEPTAGR--DQAHSPAVPAV--SPLKFHRPSREDSKTCADSDDELDQEDSGKISTTTTES 76
 
Name Accession Description Interval E-value
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 105-286 1.94e-155

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 446.88  E-value: 1.94e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20188   4 KVELEAKDLWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTA 264
Cdd:cd20188  84 MYIHPDSPSTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFKETEFIAVTA 163

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20188 164 YQNEKITQLKIDNNPFAKGFRD 185
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 106-286 4.19e-131

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 384.60  E-value: 4.19e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878   106 VHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRM 185
Cdd:pfam00907   1 VSLENKELWKKFHELGTEMIITKSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVVAGKAEPHSPPRV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878   186 YIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR-ANDILKLPYSTFRTYVFPETEFIAVTA 264
Cdd:pfam00907  81 YIHPDSPATGSHWMKQPVSFDKLKLTNNKEDKNGHIILNSMHKYQPRLHIVRvGGDEPSLPEENVKTFVFPETEFIAVTA 160

                         170       180
                  ....*....|....*....|..
gi 73853878   265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:pfam00907 161 YQNEEITQLKIDNNPFAKGFRD 182
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 105-286 4.48e-119

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 353.66  E-value: 4.48e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20189   2 KVFLENRELWQKFHEVGTEMIITKAGRRMFPSIKVKVTGLNPKTKYILLMDIVPADDHRYKFHDSEWVVAGKAEPAMPGR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILK--LPYSTFRTYVFPETEFIAV 262
Cdd:cd20189  82 LYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDQFGHIILNSMHKYQPRIHIVQADDNNAfgSKNTAFSTHVFPETAFIAV 161

                       170       180
                ....*....|....*....|....
gi 73853878 263 TAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20189 162 TAYQNHQITQLKIENNPFAKGFRG 185
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
105-291 4.73e-116

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 346.18  E-value: 4.73e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878    105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:smart00425   2 KVSLEDKELWRKFHELGTEMIVTKSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGKAEPHMPSR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878    185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFT--ILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAV 262
Cdd:smart00425  82 VYVHPDSPATGAHWMKQPVSFDKVKLTNNQSDKNGHLqiILNSMHKYQPRLHIVEVDDISKEILSQFKTFVFPETQFIAV 161

                          170       180
                   ....*....|....*....|....*....
gi 73853878    263 TAYQNDKITQLKIDNNPFAKGFRDTGNGR 291
Cdd:smart00425 162 TAYQNQKITKLKIDNNPFAKGFRDQGRRR 190
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 107-287 8.50e-101

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 307.05  E-value: 8.50e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 107 HLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKF--HNSRWMVAGKADPEMPKR 184
Cdd:cd20193   4 HLETKELWDKFHELGTEMIITKSGRRMFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYayHRSSWLVAGKADPPLPAR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR----ANDILKLPYSTFRTYVFPETEFI 260
Cdd:cd20193  84 LYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDKHGHIILNSMHKYQPRVHIVKkkdhTASLVNLKSEEFRTFIFPETVFT 163

                       170       180
                ....*....|....*....|....*..
gi 73853878 261 AVTAYQNDKITQLKIDNNPFAKGFRDT 287
Cdd:cd20193 164 AVTAYQNQLITKLKIDSNPFAKGFRDS 190
T-box_TBX1_10-like cd20187
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; ...
 105-286 2.82e-99

DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410313  Cd Length: 189  Bit Score: 302.81  E-value: 2.82e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYK--FHNSRWMVAGKADPEMP 182
Cdd:cd20187   3 TVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKIFGMDPMADYMLMMDFVPVDDKRYRyaFHSSSWLVAGKADPAMP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 183 KRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRAN---DILKLPYSTFRTYVFPETEF 259
Cdd:cd20187  83 GRIHVHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRYQPRFHVVYVDprkDSENSAEENFKTFIFPETKF 162

                       170       180
                ....*....|....*....|....*..
gi 73853878 260 IAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20187 163 TAVTAYQNHRITQLKIASNPFAKGFRD 189
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 105-286 3.06e-95

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 292.31  E-value: 3.06e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKF-HNSRWMVAGKADPE--M 181
Cdd:cd20681   2 KVTLKNRDLWQQFHREGTEMIITKSGRRMFPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYsGNGGWVPAGGAEPQppL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 182 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIA 261
Cdd:cd20681  82 PRRIYIHPDSPATGDHWMSQPISFSKVKLTNNTLDPQGNIVLTSMHKYQPRIHIVRCSDTLALPWAPTASFTFPETEFIA 161

                       170       180
                ....*....|....*....|....*
gi 73853878 262 VTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20681 162 VTAYQNERITKLKIDNNPFAKGFRE 186
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 105-286 7.76e-95

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 291.36  E-value: 7.76e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20197   2 RASLEDQDLWKKFHQIGTEMIITKSGRRMFPQCKIRVSGLLPYAKYVMLVDFVPVDNFRYKWNKDQWEVAGKAEPQPPCR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTA 264
Cdd:cd20197  82 TYVHPDSPAPGSHWMKQPISFQKLKLTNNTLDQHGHIILHSMHRYQPRFHIVQADDLFNVRWSLFQVFSFPETVFTAVTA 161

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20197 162 YQNEKITKLKIDNNPFAKGFRE 183
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 105-278 4.12e-92

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 283.72  E-value: 4.12e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEM-PK 183
Cdd:cd00182   2 TVSLRNEELWKKFHELGTEMIVTKSGRRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGKAEPPPePS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 184 RMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDK-HGFTILNSMHKYQPRFHIVRANDIlKLPYSTFRTYVFPETEFIAV 262
Cdd:cd00182  82 RIYVHPDGPQTGSFWMKKGVSFDKVKITNNKEDKkEGHILLHSMHKYIPVLTIYEVDDN-GLLSKLVKEFRFPETEFIAV 160

                       170
                ....*....|....*.
gi 73853878 263 TAYQNDKITQLKIDNN 278
Cdd:cd00182 161 TAYQNDEITQLKIDNN 176
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 106-286 1.96e-87

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 272.14  E-value: 1.96e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 106 VHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRM 185
Cdd:cd20190   3 LSLEDRELWKEFSSVGTEMIITKSGRRMFPACKVSVTGLDPEAKYLFLLDVVPVDNARYKWNKRRWEPSGKAEPHLPDRV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 186 YIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTAY 265
Cdd:cd20190  83 YIHPDSPAPGAHWMRQPISFHKLKLTNNTLDPHGHLILHSMHKYQPRIHLVQSADLCSQHWGGMASFRFPETTFIAVTAY 162

                       170       180
                ....*....|....*....|.
gi 73853878 266 QNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20190 163 QNPQITKLKIAANPFAKGFRE 183
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 105-286 5.13e-85

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 265.79  E-value: 5.13e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYK--FHNSRWMVAGKADPEMP 182
Cdd:cd20682   2 QVELCSRELWLQFHNLGNEMIITKAGRRMFPALKVKLTGLDPDKLYIVWVDIVPVDSNRYRyvYHSSKWVVAGSGDVLPP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 183 KRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDK-HGFTILNSMHKYQPRFHIVRANDILKLPY-----STFRTYVFPE 256
Cdd:cd20682  82 ANRYIHPDSPASGKYWMSQIVSFDKLKLTNNKEPKqKGQISLHSMHKYQPRIHIQPVEDDGRNVEkainsSKALSFEFPE 161

                       170       180       190
                ....*....|....*....|....*....|
gi 73853878 257 TEFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20682 162 TSFITVTAYQNQQITKLKIASNPFAKGFRD 191
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 105-286 2.45e-83

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 261.75  E-value: 2.45e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKF--HNSRWMVAGKADPEMP 182
Cdd:cd20191   4 QVELQGSELWKRFHDIGTEMIITKAGRRMFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYvyHSSKWMVAGNADAPVP 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 183 KRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVR-------ANDILKLPYSTFRTYVFP 255
Cdd:cd20191  84 PRVYIHPDSPASGETWMRQVVSFDKLKLTNNEMDDQGHIILHSMHKYQPRVHVIRkdsstdlSPKKPVPPGEGVKTFSFP 163

                       170       180       190
                ....*....|....*....|....*....|.
gi 73853878 256 ETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20191 164 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 194
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 105-286 1.82e-82

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 259.03  E-value: 1.82e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20196   2 RMSLENAELWKQFSSVGTEMIITKAGRRMFPQLRVSVSGLDPEARYLLLLDVVPVDGSRYRWQGNSWEASGKAEPRLPDR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILkLPYSTFRTYVFPETEFIAVTA 264
Cdd:cd20196  82 VYIHPDSPATGAHWMRQPISFHRAKLTNNTLDPHGHIILHSMHRYQPRVHVVRARDVL-SWGGGCASFTFPETQFITVTA 160

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20196 161 YQNPKITQLKINSNPFAKGFRE 182
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 105-286 1.32e-81

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 256.42  E-value: 1.32e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20192   2 RVTLEDRELWKKFHSLTNEMIVTKSGRRMFPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYVNGEWVPGGKAEPPPPSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKhGFTILNSMHKYQPRFHIVRAN-DILKLPYSTFRtyvFPETEFIAVT 263
Cdd:cd20192  82 VYVHPDSPNFGAHWMKGPVSFSKVKLTNKPNGE-GQIMLNSLHKYEPRVHIVRVGsNNHERLVSTFS---FPETQFIAVT 157

                       170       180
                ....*....|....*....|...
gi 73853878 264 AYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20192 158 AYQNEEITALKIKYNPFAKAFLD 180
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 105-286 1.03e-79

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 251.97  E-value: 1.03e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20195   2 TVTLENNSMWNEFYRCGTEMILTKQGRRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRWNGRWWEPSGKAEPHVLGR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIV---RANDILKLPYSTFRTYVFPETEFIA 261
Cdd:cd20195  82 VFIHPESPATGRHWMDQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHVVpadKEVDVIQLNGPDVHTFTFPQTEFFA 161

                       170       180
                ....*....|....*....|....*
gi 73853878 262 VTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20195 162 VTAYQNKQITQLKIDYNPFAKGFRE 186
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 106-286 4.49e-77

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 245.08  E-value: 4.49e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 106 VHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMP-KR 184
Cdd:cd20194   4 VYLCNRDLWLKFHQHQTEMIITKQGRRMFPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKFQSGKWVPCGKAEGLPQgNR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETEFIAVTA 264
Cdd:cd20194  84 VYVHPDSPNTGAHWMKQEISFSKLKLTNNKGADQGMIVLNSMHKYQPRIHVIEVGGNGPNEQRNLQTHSFPETQFIAVTA 163

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20194 164 YQNTDITQLKIDHNPFAKGFRD 185
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 105-286 3.43e-74

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 237.90  E-value: 3.43e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKF--HNSRWMVAGKADPE-M 181
Cdd:cd20200   4 QVELQGSELWKRFHEIGTEMIITKAGRRMFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRYvyHSSQWMVAGNTDHScI 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 182 PKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIV----RAN--DILKLPYSTFRTYVFP 255
Cdd:cd20200  84 TPRLYVHPDSPCSGETWMRQIISFDRVKLTNNEMDDKGHIILQSMHKYKPRVHVIlqdsRFDlsQIQSLPAEGVKTFSFP 163

                       170       180       190
                ....*....|....*....|....*....|.
gi 73853878 256 ETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20200 164 ETEFTTVTAYQNQQITKLKIDRNPFAKGFRD 194
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 105-286 1.21e-72

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 233.78  E-value: 1.21e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKF--HNSRWMVAGKADPEMP 182
Cdd:cd20199   5 RVDLQGADLWKRFHEIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 183 KRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRA------NDILKLPYST-FRTYVFP 255
Cdd:cd20199  85 PRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKecgeelSPVKPIPSGEgVKAFSFP 164

                       170       180       190
                ....*....|....*....|....*....|.
gi 73853878 256 ETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20199 165 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 195
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 105-286 2.68e-68

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 222.14  E-value: 2.68e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMP-K 183
Cdd:cd20203   3 QVLLNNHPLWSKFHKHQTEMIITKQGRRMFPFLSFNLTGLDPTAHYNVYVDVVLADQHHWRYQGGKWVQCGKAEGNMPgN 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 184 RMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFT---ILNSMHKYQPRFHIVRAND---ILKLPYSTFRTYVFPET 257
Cdd:cd20203  83 RLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTqmiVLQSLHKYQPRLHIVEVKEgetEEAYSSSKTHTFTFPET 162

                       170       180
                ....*....|....*....|....*....
gi 73853878 258 EFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20203 163 QFIAVTAYQNAEITQLKIDHNPFAKGFRD 191
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 105-286 3.03e-68

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 222.29  E-value: 3.03e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKF--HNSRWMVAGKADPEMP 182
Cdd:cd20198   8 QVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYvyHSSKWMVAGNADSPVP 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 183 KRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYST-------FRTYVFP 255
Cdd:cd20198  88 PRVYIHPDSLASGDTWMRQVVSFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKpvptgdgVKTFSFP 167

                       170       180       190
                ....*....|....*....|....*....|.
gi 73853878 256 ETEFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20198 168 ETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 198
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 105-286 4.54e-66

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 215.67  E-value: 4.54e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20202   3 KVSLEESELWLRFKELTNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAPSC 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKhGFTILNSMHKYQPRFHIVRANDILKLpystFRTYVFPETEFIAVTA 264
Cdd:cd20202  83 VYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGG-GQIMLNSLHKYEPRIHIVRVGGPQRM----ITSHSFPETQFIAVTA 157

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20202 158 YQNEEITALKIKYNPFAKAFLD 179
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 106-287 5.06e-60

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 200.70  E-value: 5.06e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 106 VHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGK--------- 176
Cdd:cd20683   3 LLLEDADLWAQFHSVQNEMIITKSGRCLFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFRNGRWNPIDKdqrgddafs 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 177 -ADPEM---PKRMYIHPDSPATGEQWMSKVVTFHKLKLTN---NISDKH---------------GFTILNSMHKYQPRFH 234
Cdd:cd20683  83 sGTADKsvlLPESYIHPDGPQTGAFWMANGISFAKIKLSNrqpNSSDRDgpkenitnsisalpdGHFFLTSFHKYQPRLH 162

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 73853878 235 IV-RANDILKLPYSTfrTYVFPETEFIAVTAYQNDKITQLKIDNNPFAKGFRDT 287
Cdd:cd20683 163 LIqHSAGDHDDILST--TFTFEETEFIAVTHYQNEKVNILKKDYNPHAKGFKDD 214
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 105-286 2.57e-59

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 198.03  E-value: 2.57e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMP-K 183
Cdd:cd20204   3 QVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQgN 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 184 RMYIHPDSPATGEQWMSKVVTFHKLKLTNN--ISDKHG-FTILNSMHKYQPRFHIVRANDILKLPYST---FRTYVFPET 257
Cdd:cd20204  83 RVYMHPDSPNTGAHWMRQEISFGKLKLTNNkgASNNNGqMVVLQSLHKYQPRLHVVEVNEDGTEDTSQpgrVQTFTFPET 162

                       170       180
                ....*....|....*....|....*....
gi 73853878 258 EFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20204 163 QFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 105-286 8.42e-59

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 196.82  E-value: 8.42e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMP-K 183
Cdd:cd20205   3 QVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQgN 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 184 RMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHGFT---ILNSMHKYQPRFHIVRAND----ILKLPYSTfRTYVFPE 256
Cdd:cd20205  83 KVYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNNTqmiVLQSLHKYQPRLHIVEVSEdgveDLNDSSKT-QTFTFPE 161

                       170       180       190
                ....*....|....*....|....*....|
gi 73853878 257 TEFIAVTAYQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20205 162 NQFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 105-286 4.29e-58

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 194.48  E-value: 4.29e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 105 KVHLEGKDLWEQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKR 184
Cdd:cd20201   7 QVSLEDAELWQRFKEVTNEMIVTKNGRRMFPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYVNGEWVPAGKPEPHSHSC 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878 185 MYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKhGFTILNSMHKYQPRFHIVRANDilklPYSTFRTYVFPETEFIAVTA 264
Cdd:cd20201  87 VYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGG-GQIMLNSLHKYEPQIHIVRVGG----PHRMVTNCSFPETQFIAVTA 161

                       170       180
                ....*....|....*....|..
gi 73853878 265 YQNDKITQLKIDNNPFAKGFRD 286
Cdd:cd20201 162 YQNEEITALKIKYNPFAKAFLD 183
TBX pfam12598
T-box transcription factor; This domain family is found in eukaryotes, and is typically ...
 304-381 2.58e-14

T-box transcription factor; This domain family is found in eukaryotes, and is typically between 77 and 89 amino acids in length. The family is found in association with pfam00907. There are two completely conserved residues (S and P) that may be functionally important. T-box genes encode transcription factors involved in morphogenesis and organogenesis of vertebrates and invertebrates


Pssm-ID: 432659  Cd Length: 81  Bit Score: 68.65  E-value: 2.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73853878   304 RPYDDH--QKKDNGSSDESSSEQTAYKcfAQTSSPTAPAVgtSSLKGVPPSDGESDEESRDEGGPDTGESTKISTTTSED 381
Cdd:pfam12598   1 RMYEEQckQDRDGGTSDASSGEPTAGR--DQAHSPAVPAV--SPLKFHRPSREDSKTCADSDDELDQEDSGKISTTTTES 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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