|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
38-511 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 768.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 38 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYdEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVS 117
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 118 IDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKH 197
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 198 SFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAG-SCKGVKVMFNGKKLPVNG 275
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 276 FRSYVDLYVKDKLDETGvaLKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNK 355
Cdd:PLN03128 241 FQDYVGLYLGPNSREDP--LPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 356 AGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLnKK 435
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74188146 436 CSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIM 511
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIM 473
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
89-511 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 555.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 89 GLYKIFDEILVNAADNKQRDKnMTCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 168
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 169 GGRNGYGAKLCNIFSTKFTVETACKeyKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKldKDIVALM 248
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 249 TRRAYDLAGSCKGVKVMFNGKK-------LPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKG-FQQI 320
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 321 SFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGV-SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFG- 398
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEkNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 399 ----SKCQLSEKFFKAASNCGIVESILNWVKFKAQTQ-LNKKCSSVKYSKIKGIPKLDDANDAGGKhslECTLILTEGDS 473
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430
....*....|....*....|....*....|....*...
gi 74188146 474 AKSLAVSGLgviGRDRYGVFPLRGKILNVREASHKQIM 511
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKIL 426
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
86-231 |
1.51e-103 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 306.57 E-value: 1.51e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 86 FVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 165
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74188146 166 KVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHF-DGEDYTCITFQPD 231
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
275-435 |
2.87e-32 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 121.57 E-value: 2.87e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 275 GFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTL---SEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVK 351
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 352 KKN---KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFK-AASNCGIVESILNWVKFK 427
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEfLEENPEIAKKILEKALQA 160
|
....*...
gi 74188146 428 AQTQLNKK 435
Cdd:pfam00204 161 AKARLAAR 168
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
49-511 |
7.30e-17 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 83.54 E-value: 7.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 49 LEHILLRPDTYIGSVepltqlmwvyDEDvgmncrevtfvpGLYKIFDEILVNA--------ADNkqrdknmtcIKVSIDP 120
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 121 EsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHS 198
Cdd:COG0187 66 D-GSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrdGKIYRQR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 199 FKQTwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMFNGKKLPV----- 273
Cdd:COG0187 145 FERG-----KPVGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLA---ERLRELAFLNKGLTITLTDEREEEpkeet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 274 ----NGFRSYVDLYVKDKldeTGVALKVIH---ELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHV---------- 335
Cdd:COG0187 217 fhyeGGIKDFVEYLNEDK---EPLHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrtaltrv 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 336 --DYVVDQvvsKLIevvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKEN-MTLQPKSFGSK 400
Cdd:COG0187 294 inDYARKN---GLL---KEKDKnltgddvregltAVISVK---------------LPEPQFEGQTKTKlGNSEARGIVES 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 401 C---QLSEKFfkaASNCGIVESILNWV--------KFKAQTQLNKKCSSVKyskIKGIP-KLDDA--NDAGgkhslECTL 466
Cdd:COG0187 353 VvseKLEHYL---EENPAEAKKILEKAilaarareAARKARELVRRKSALE---SSGLPgKLADCssKDPE-----ESEL 421
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 74188146 467 ILTEGDSA----KSlavsglgviGRDRY--GVFPLRGKILNVREASHKQIM 511
Cdd:COG0187 422 FIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKIL 463
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
38-511 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 768.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 38 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYdEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVS 117
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 118 IDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKH 197
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 198 SFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAG-SCKGVKVMFNGKKLPVNG 275
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 276 FRSYVDLYVKDKLDETGvaLKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNK 355
Cdd:PLN03128 241 FQDYVGLYLGPNSREDP--LPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 356 AGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLnKK 435
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74188146 436 CSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIM 511
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIM 473
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
34-511 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 756.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 34 TKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKN-- 110
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKGgh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 111 -MTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 189
Cdd:PTZ00108 81 rMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 190 TACKEYKHSFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNG 268
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 269 KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIE 348
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 349 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKA 428
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 429 QTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHK 508
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
...
gi 74188146 509 QIM 511
Cdd:PTZ00108 481 QLM 483
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
20-511 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 679.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 20 TKKEELETANKNDSTKKL-------SVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDvGMNCREVTFVPGLYK 92
Cdd:PLN03237 2 AEKLPLQESNSANVAAAPaassggkTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETD-KMVQRSVTYVPGLYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 93 IFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRN 172
Cdd:PLN03237 81 IFDEILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 173 GYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKI-KHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRR 251
Cdd:PLN03237 161 GYGAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEPVItKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 252 AYDLAGSC-KGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTK 330
Cdd:PLN03237 241 VVDIAGCLgKTVKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 331 GGRHVDYVVDQVVSKLIEVVKKKNKAGvSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKA 410
Cdd:PLN03237 321 GGTHVDYVTNQIANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKK 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 411 ASNCGIVESILNWVKFKAQTQLnKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRY 490
Cdd:PLN03237 400 VMKSGIVENLLSWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYY 478
|
490 500
....*....|....*....|.
gi 74188146 491 GVFPLRGKILNVREASHKQIM 511
Cdd:PLN03237 479 GVFPLRGKLLNVREASHKQIM 499
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
89-511 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 555.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 89 GLYKIFDEILVNAADNKQRDKnMTCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 168
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 169 GGRNGYGAKLCNIFSTKFTVETACKeyKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKldKDIVALM 248
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 249 TRRAYDLAGSCKGVKVMFNGKK-------LPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKG-FQQI 320
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 321 SFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGV-SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFG- 398
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEkNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 399 ----SKCQLSEKFFKAASNCGIVESILNWVKFKAQTQ-LNKKCSSVKYSKIKGIPKLDDANDAGGKhslECTLILTEGDS 473
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430
....*....|....*....|....*....|....*...
gi 74188146 474 AKSLAVSGLgviGRDRYGVFPLRGKILNVREASHKQIM 511
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKIL 426
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
86-231 |
1.51e-103 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 306.57 E-value: 1.51e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 86 FVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 165
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74188146 166 KVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHF-DGEDYTCITFQPD 231
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
274-426 |
3.13e-89 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 269.93 E-value: 3.13e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 274 NGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKK 353
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74188146 354 NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKF 426
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
50-511 |
1.51e-61 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 211.92 E-value: 1.51e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 50 EHILLRPDTYIGSV--EPLTQLMwvydedVGmNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISI 127
Cdd:PHA02569 11 EHILKRPGMYIGSVayEAHERFL------FG-KFTQVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 128 WNNGKGIP---VVEHKVEKVYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTwm 204
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCS-- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 205 NNM----MKTSEAKIKHfdgedyTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNgFRSYV 280
Cdd:PHA02569 161 NGAenisWSTKPGKGKG------TSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 281 DLYVKDKldetgvalkVIHElaNERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGVSv 360
Cdd:PHA02569 234 KQFGDDT---------IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHKIEVT- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 361 KPfQVKN--HIWVFINCLIeNPTFDSQTKENMTLQPKSFGSKCQLSEKFF--KAASNCGIVESILNWVKFK-------AQ 429
Cdd:PHA02569 302 KA-RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakQILKTEAIIMPIIEAALARklaaekaAE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 430 TQLNKKCSSVKYSK-IKgipklddANDAGgkHSLECTLILTEGDSAKSLAVSglgVIGRDRYGVFPLRGKILNVREASHK 508
Cdd:PHA02569 380 TKAAKKAKKAKVAKhIK-------ANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYA 447
|
...
gi 74188146 509 QIM 511
Cdd:PHA02569 448 DIL 450
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
49-511 |
1.72e-35 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 140.24 E-value: 1.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 49 LEHILLRPDTYIGSvepltqlmwvYDEDvgmncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 121
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 122 sNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSF 199
Cdd:PRK05559 69 -GSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVKrdGKVYRQRF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 200 KqtwmNNMMKTSEAKI-KHFDGEDYTCITFQPDLS-----KFKMEKLDKdivalMTRR-AYdLagsCKGVKVMFNGKKLP 272
Cdd:PRK05559 148 E----GGDPVGPLEVVgTAGKRKTGTRVRFWPDPKifdspKFSPERLKE-----RLRSkAF-L---LPGLTITLNDERER 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 273 V-----NGFRSYVDLYVKDKL---DETGVALKviHELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHVDYVVDQVV 343
Cdd:PRK05559 215 QtfhyeNGLKDYLAELNEGKEtlpEEFVGSFE--GEAEGEAVEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 344 SKLIEVVKKKN--KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENM-TLQPKSFGSKcQLSEKF-FKAASNCGIVES 419
Cdd:PRK05559 293 KAVREFAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARRFVSG-VVKDAFdLWLNQNPELAEK 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 420 ILNWVKFKAQTQLNKKCSSVKYSKIKGI---PKLddaNDAGGKHSLECTLILTEGDSAkslavSGLGVIGRDRY--GVFP 494
Cdd:PRK05559 372 LAEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAILP 443
|
490
....*....|....*..
gi 74188146 495 LRGKILNVREASHKQIM 511
Cdd:PRK05559 444 LRGKILNTWEASLDDVL 460
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
275-435 |
2.87e-32 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 121.57 E-value: 2.87e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 275 GFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTL---SEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVK 351
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 352 KKN---KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFK-AASNCGIVESILNWVKFK 427
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEfLEENPEIAKKILEKALQA 160
|
....*...
gi 74188146 428 AQTQLNKK 435
Cdd:pfam00204 161 AKARLAAR 168
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
464-511 |
1.47e-29 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 112.39 E-value: 1.47e-29
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 74188146 464 CTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIM 511
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIM 48
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
49-511 |
7.95e-18 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 86.69 E-value: 7.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 49 LEHILLRPDTYIGSVEP--LTQLMW-VYDEDVgmncrevtfvpglykifDEILVNAADNkqrdknmtcIKVSIDPEsNII 125
Cdd:PRK05644 19 LEAVRKRPGMYIGSTGErgLHHLVYeIVDNSI-----------------DEALAGYCDH---------IEVTINED-GSI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 126 SIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSFKQ 201
Cdd:PRK05644 72 TVTDNGRGIPVDIHPKTGK--PAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEVKrdGKIYYQEYER 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 202 TwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMF----NGKKLPV---- 273
Cdd:PRK05644 150 G-----VPVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtderEGEEKEEtfhy 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 274 -NGFRSYVDLYVKDKldetgvalKVIHE----LANERWDVCLtlsEKGFQQ--------ISFVNSIATTKGGRHV----- 335
Cdd:PRK05644 222 eGGIKEYVEYLNRNK--------EPLHEepiyFEGEKDGIEV---EVAMQYndgyseniLSFANNINTHEGGTHEegfkt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 336 -------DYVVDqvvSKLIevvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTK------ENM 390
Cdd:PRK05644 291 altrvinDYARK---NKLL---KEKDDnltgedvregltAVISVK---------------HPEPQFEGQTKtklgnsEVR 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 391 TLQPKSFGSKcqLSEkFFKaaSNCGIVESILNWVKFKAQT--------QLNKKCSSVKYSkikGIP-KLDD--ANDAGgk 459
Cdd:PRK05644 350 GIVDSVVSEA--LSE-FLE--ENPNVAKKIVEKAILAARAreaarkarELTRRKSALESS---SLPgKLADcsSKDPE-- 419
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 74188146 460 hslECTLILTEGDSAKSLAVSGlgvigRDRY--GVFPLRGKILNVREASHKQIM 511
Cdd:PRK05644 420 ---ESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKIL 465
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
49-511 |
7.30e-17 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 83.54 E-value: 7.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 49 LEHILLRPDTYIGSVepltqlmwvyDEDvgmncrevtfvpGLYKIFDEILVNA--------ADNkqrdknmtcIKVSIDP 120
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 121 EsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHS 198
Cdd:COG0187 66 D-GSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrdGKIYRQR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 199 FKQTwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMFNGKKLPV----- 273
Cdd:COG0187 145 FERG-----KPVGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLA---ERLRELAFLNKGLTITLTDEREEEpkeet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 274 ----NGFRSYVDLYVKDKldeTGVALKVIH---ELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHV---------- 335
Cdd:COG0187 217 fhyeGGIKDFVEYLNEDK---EPLHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrtaltrv 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 336 --DYVVDQvvsKLIevvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKEN-MTLQPKSFGSK 400
Cdd:COG0187 294 inDYARKN---GLL---KEKDKnltgddvregltAVISVK---------------LPEPQFEGQTKTKlGNSEARGIVES 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 401 C---QLSEKFfkaASNCGIVESILNWV--------KFKAQTQLNKKCSSVKyskIKGIP-KLDDA--NDAGgkhslECTL 466
Cdd:COG0187 353 VvseKLEHYL---EENPAEAKKILEKAilaarareAARKARELVRRKSALE---SSGLPgKLADCssKDPE-----ESEL 421
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 74188146 467 ILTEGDSA----KSlavsglgviGRDRY--GVFPLRGKILNVREASHKQIM 511
Cdd:COG0187 422 FIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKIL 463
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
90-267 |
2.74e-13 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 67.95 E-value: 2.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 90 LYKIFDEILVNAADnkqrdKNM----TCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 165
Cdd:cd16928 1 LHHLVWEIVDNSID-----EALagyaTEIEVTLHED-NSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 166 KVTGGRNGYGAKLCNIFSTKF--TVETACKEYKHSFKqtwmnNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKD 243
Cdd:cd16928 75 KVSGGLHGVGVSVVNALSERLevEVKRDGKIYRQEFS-----RGGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFD 149
|
170 180
....*....|....*....|....
gi 74188146 244 IVAlmtRRAYDLAGSCKGVKVMFN 267
Cdd:cd16928 150 TLK---RRLRELAFLNKGLKIVLE 170
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
276-388 |
1.69e-10 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 58.04 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 276 FRSYVDLYVKDKldetgVALKVIH---ELANERWDVCLTLSE----KGFQQISFVNSIATTKGGRHVDYVVDQVVSKLie 348
Cdd:cd00329 1 LKDRLAEILGDK-----VADKLIYvegESDGFRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 74188146 349 vvkkknkagvsvKPFQVKNHIWVFINCLIEN--PTFD-SQTKE 388
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
89-186 |
4.30e-07 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 48.52 E-value: 4.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 89 GLYKIFDEILVNAADNKQrdkNMTCIKVSIDPESNI-ISIWNNGKGIPVVEHKvekvyvpaLIFGQLLTSSnydddekKV 167
Cdd:pfam02518 5 RLRQVLSNLLDNALKHAA---KAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90
....*....|....*....
gi 74188146 168 TGGRNGYGAKLCNIFSTKF 186
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELL 85
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
49-505 |
8.37e-07 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 51.63 E-value: 8.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 49 LEHILLRPDTYIGsvepltqlmwvyDEDVGMncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 121
Cdd:PRK14939 18 LDAVRKRPGMYIG------------DTDDGT---------GLHHMVYEVVDNAIDealaghcDD--------ITVTIHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 122 sNIISIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKF--TVETACKEYKH 197
Cdd:PRK14939 69 -GSVSVSDNGRGIPTDIHPEEGV--SAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLelTIRRDGKIHEQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 198 SFKQTWMNNMMKTSEAKIKHfdGedyTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCKGVKVMF----NGKKLP- 272
Cdd:PRK14939 146 EFEHGVPVAPLKVVGETDKT--G---TEVRFWPSPEIFENTEFDYDILA---KRLRELAFLNSGVRIRLkderDGKEEEf 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 273 -----VNGFRSYVDlyvKDKldeTGVALKVIHeLANERWDVCLTLS---EKGFQQ--ISFVNSIATTKGGRHV------- 335
Cdd:PRK14939 218 hyeggIKAFVEYLN---RNK---TPLHPNIFY-FSGEKDGIGVEVAlqwNDSYQEnvLCFTNNIPQRDGGTHLagfraal 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 336 -----DYVVDQVVSKlievvKKKNK-----------AGVSVKpfqvknhiwvfinclIENPTFDSQTKENMtlqpksfGS 399
Cdd:PRK14939 291 trtinNYIEKEGLAK-----KAKVSltgddaregltAVLSVK---------------VPDPKFSSQTKDKL-------VS 343
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 400 kcqlSE-KffkaasncGIVESILNwvkfkaqTQL------NKKCSSVKYSKI-------------------KGIpkLDDA 453
Cdd:PRK14939 344 ----SEvR--------PAVESLVN-------EKLsefleeNPNEAKIIVGKIidaarareaarkareltrrKGA--LDIA 402
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74188146 454 N------DAGGKHSLECTLILTEGDSA----KSlavsglgviGRDRygVF----PLRGKILNVREA 505
Cdd:PRK14939 403 GlpgklaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDR--KFqailPLKGKILNVEKA 457
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
89-189 |
1.10e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 47.26 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 89 GLYKIFDEILVNAADNKQRDKNMTcIKVSIDPESNIISIWNNGKGIPvvEHKVEKVYVPaliFGQLltssnyddDEKKVT 168
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRIT-VTLERDGDHVEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRSRK 70
|
90 100
....*....|....*....|.
gi 74188146 169 GGRNGYGAKLCNIFSTKFTVE 189
Cdd:smart00387 71 IGGTGLGLSIVKKLVELHGGE 91
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
275-511 |
3.46e-03 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 40.25 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 275 GFRSYVDLYVKDKL----DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTkGGRHVD---YVVDQVVSKLI 347
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDgfkYAITRCVNGNI 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 348 evvkKKNKA-GVSVKPFQ---VKNHIWVFINCLIENPTFDSQTKEnmtlqpksfgskcQLSEKFFKAasncgIVESILNW 423
Cdd:PTZ00109 455 ----KKNGYfKGNFVNIPgefIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74188146 424 vKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAG-----------------GKHSlECT--------LILTEGDSAkslA 478
Cdd:PTZ00109 513 -QLSEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirqknnqyystilpGKLV-DCIsddierneLFIVEGESA---A 587
|
250 260 270
....*....|....*....|....*....|....
gi 74188146 479 VSGLGVIGRDRYGVFPLRGKILNVRE-ASHKQIM 511
Cdd:PTZ00109 588 GNAKQARNREFQAVLPLKGKILNIEKiKNNKKVF 621
|
|
| |
