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Conserved domains on  [gi|74196263|dbj|BAE33032|]
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unnamed protein product [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-80 5.22e-24

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.74  E-value: 5.22e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 74196263     23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVGYPVPSPGAIFRIKKRKE 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
382-817 1.18e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 1.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 382 RPYVCPVCGKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSCTSR--LKVHYQIHMKEKPYECGDCG---KAFKRKSSLT 456
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 457 VHQKIHIRQTHHECSECGKTFNQKSELSTHQRLHLGKNSHRcsDCGKSFT----YASQLKMHRRVHTGEKPYKCRDcgks 532
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP--GNNSSSVntpqSNSLHPPLPANSLSKDPSSNLS---- 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 533 ftysftLNVHRRIHKVEKPHKCSICGKALASKYQLEEHERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHK 612
Cdd:COG5048 186 ------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 613 CGKAFFQRSQLTSHQQTHTGekpytchycgkSFSHTSQLTvhhrihtgerPYKCDYCAKSFSNSSQLKEHLR--IHTGE- 689
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESD-----------SSSEKGFSL----------PIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 690 -TPYACSE--CGKAFSRRSSLNLHTKIHTGEKHHIC--SECGKAFSQKSVLRTHQRI--HTGEKPYKCSDCGKALASKGQ 762
Cdd:COG5048 319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNF 398

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74196263 763 LRDHQRI-----HTGEKPYMC--PECGKGFFGRSSLHRHQITHTKERPFVCQKCGKTFIQKS 817
Cdd:COG5048 399 KRDSNLSlhiitHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 317-404 1.28e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 317 ASHQETHPEKPYECP--DCGKSFSRTSNLQvHHRIHTGEKPyecrdcgKSFNNTSQLKvHYRIHTGERPYVCPVCGKAFK 394
Cdd:COG5189 339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLK-YHMLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYK 409

                        90
                ....*....|
gi 74196263 395 QKSILSTHET 404
Cdd:COG5189 410 NLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
800-867 5.25e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 5.25e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 800 KERPFVCQKCGKTFIQKSALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHTRGRSFVCQKCGK 867
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-80 5.22e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.74  E-value: 5.22e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 74196263     23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVGYPVPSPGAIFRIKKRKE 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-63 1.48e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 1.48e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 74196263    22 LVSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVG 63
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-59 2.23e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 2.23e-16
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 74196263  23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHL 59
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
382-817 1.18e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 1.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 382 RPYVCPVCGKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSCTSR--LKVHYQIHMKEKPYECGDCG---KAFKRKSSLT 456
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 457 VHQKIHIRQTHHECSECGKTFNQKSELSTHQRLHLGKNSHRcsDCGKSFT----YASQLKMHRRVHTGEKPYKCRDcgks 532
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP--GNNSSSVntpqSNSLHPPLPANSLSKDPSSNLS---- 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 533 ftysftLNVHRRIHKVEKPHKCSICGKALASKYQLEEHERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHK 612
Cdd:COG5048 186 ------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 613 CGKAFFQRSQLTSHQQTHTGekpytchycgkSFSHTSQLTvhhrihtgerPYKCDYCAKSFSNSSQLKEHLR--IHTGE- 689
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESD-----------SSSEKGFSL----------PIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 690 -TPYACSE--CGKAFSRRSSLNLHTKIHTGEKHHIC--SECGKAFSQKSVLRTHQRI--HTGEKPYKCSDCGKALASKGQ 762
Cdd:COG5048 319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNF 398

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74196263 763 LRDHQRI-----HTGEKPYMC--PECGKGFFGRSSLHRHQITHTKERPFVCQKCGKTFIQKS 817
Cdd:COG5048 399 KRDSNLSlhiitHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 317-404 1.28e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 317 ASHQETHPEKPYECP--DCGKSFSRTSNLQvHHRIHTGEKPyecrdcgKSFNNTSQLKvHYRIHTGERPYVCPVCGKAFK 394
Cdd:COG5189 339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLK-YHMLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYK 409

                        90
                ....*....|
gi 74196263 395 QKSILSTHET 404
Cdd:COG5189 410 NLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-395 4.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.81e-04
                          10        20
                  ....*....|....*....|....*
gi 74196263   371 LKVHYRIHTGERPYVCPVCGKAFKQ 395
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 5.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 74196263   342 NLQVHHRIHTGEKPYECRDCGKSFNN 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
800-867 5.25e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 5.25e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 800 KERPFVCQKCGKTFIQKSALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHTRGRSFVCQKCGK 867
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
PHA00733 PHA00733
hypothetical protein
 663-722 5.00e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 5.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263  663 PYKCDYCAKSFSNSSQLKEHLRIhtGETPYACSECGKAFSRRSSlnlhTKIHTGEKHHIC 722
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDS----TLDHVCKKHNIC 126
zf-H2C2_2 pfam13465
Zinc-finger double domain;
818-841 7.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.10e-03
                          10        20
                  ....*....|....*....|....
gi 74196263   818 ALTSHQQIHTGEKPYVCPECGKGF 841
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-80 5.22e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.74  E-value: 5.22e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 74196263     23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVGYPVPSPGAIFRIKKRKE 80
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 22-63 1.48e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.52  E-value: 1.48e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 74196263    22 LVSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHLLAVG 63
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-59 2.23e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 2.23e-16
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 74196263  23 VSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYSHL 59
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
382-817 1.18e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 1.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 382 RPYVCPVCGKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSCTSR--LKVHYQIHMKEKPYECGDCG---KAFKRKSSLT 456
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLplsNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 457 VHQKIHIRQTHHECSECGKTFNQKSELSTHQRLHLGKNSHRcsDCGKSFT----YASQLKMHRRVHTGEKPYKCRDcgks 532
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLP--GNNSSSVntpqSNSLHPPLPANSLSKDPSSNLS---- 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 533 ftysftLNVHRRIHKVEKPHKCSICGKALASKYQLEEHERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHK 612
Cdd:COG5048 186 ------LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 613 CGKAFFQRSQLTSHQQTHTGekpytchycgkSFSHTSQLTvhhrihtgerPYKCDYCAKSFSNSSQLKEHLR--IHTGE- 689
Cdd:COG5048 260 SPRSSLPTASSQSSSPNESD-----------SSSEKGFSL----------PIKSKQCNISFSRSSPLTRHLRsvNHSGEs 318

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 690 -TPYACSE--CGKAFSRRSSLNLHTKIHTGEKHHIC--SECGKAFSQKSVLRTHQRI--HTGEKPYKCSDCGKALASKGQ 762
Cdd:COG5048 319 lKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNF 398

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74196263 763 LRDHQRI-----HTGEKPYMC--PECGKGFFGRSSLHRHQITHTKERPFVCQKCGKTFIQKS 817
Cdd:COG5048 399 KRDSNLSlhiitHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
493-874 1.27e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 493 KNSHRCSDCGKSFTYASQLKMHRRVHTGEKPYKCRDCGKSFTYSFTLN--VHRRIHKVEKPHKCSI-CGKALASKYQLEE 569
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKsLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 570 HERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQTHTGEKPYTCHYCGKSFSHTS 649
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 650 QLTVHHRIHT----GERPYKcdycaKSFSNSSQLKEHLRIHT-GETPYACSECGKAFSRRSSLNLHTKIHTGEKHHICSE 724
Cdd:COG5048 191 NVSTSIPSSSenspLSSSYS-----IPSSSSDQNLENSSSSLpLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 725 CGKAFSQKSVLRTHQRIHTG-EKPYKCSDCGKALASKGQLRDHQR--IHTGE--KPYMCPE--CGKGFFGRSSLHRHQIT 797
Cdd:COG5048 266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 798 HTKERPFVC--QKCGKTFIQKS-----ALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHT--RGRSFVCQKCG 866
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCS 425


                ....*...
gi 74196263 867 KAFSRSLC 874
Cdd:COG5048 426 KSFNRHYN 433
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
300-684 1.18e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 1.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 300 PFVCHKCGEAF----LQKTEFASHQethPEKPYECPD--CGKSFSRTSNLQVHHRIHTGEKPYECRDCGKSFNNTS---- 369
Cdd:COG5048  33 PDSCPNCTDSFsrleHLTRHIRSHT---GEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAssss 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 370 -------------------------QLKVHYRIHTGERPYVCPVC-GKAFKQKSILSTHETIHTGEKPYKCTVCGKLFSC 423
Cdd:COG5048 110 lsssssnsndnnllsshslppssrdPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 424 TSR---LKVHYQIHMKEKPYECGDCGKAFKRKSSLTvHQKIHIRQTHHECSecgKTFNQKSELSTHQRLHLGKNSHRCSD 500
Cdd:COG5048 190 SNVstsIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSSASESPRSSL 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 501 CGKSFTYASQLKMHRRVHTG-EKPYKCRDCGKSFTYSFTLNVHRR--IHKVE--KPHKC--SICGKALASKYQLEEHERI 573
Cdd:COG5048 266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 574 HTGEKPYVC--TECGKGFHGRSGFLRHQITHTR-----DKPFVC--HKCGKAFFQRSQLTSHQQTHTGEKPYTCH--YCG 642
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYkdlknDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 74196263 643 KSFSHTSQLTVHHRIHTGERPYKCDyCAKSFSNSSQLKEHLR 684
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 317-404 1.28e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 317 ASHQETHPEKPYECP--DCGKSFSRTSNLQvHHRIHTGEKPyecrdcgKSFNNTSQLKvHYRIHTGERPYVCPVCGKAFK 394
Cdd:COG5189 339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLK-YHMLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYK 409

                        90
                ....*....|
gi 74196263 395 QKSILSTHET 404
Cdd:COG5189 410 NLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 515-605 1.97e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 515 RRVHTGEKPYKCR--DCGKSFTYSFTLNVHRRihkveKPHkcsiCGKALASKYQLEEHERIHTGEKPYVCTECGKGFHGR 592
Cdd:COG5189 341 MLKVKDGKPYKCPveGCNKKYKNQNGLKYHML-----HGH----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNL 411

                        90
                ....*....|...
gi 74196263 593 SGfLRHQITHTRD 605
Cdd:COG5189 412 NG-LKYHRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-395 4.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.81e-04
                          10        20
                  ....*....|....*....|....*
gi 74196263   371 LKVHYRIHTGERPYVCPVCGKAFKQ 395
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 5.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 74196263   342 NLQVHHRIHTGEKPYECRDCGKSFNN 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
800-867 5.25e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 5.25e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 800 KERPFVCQKCGKTFIQKSALTSHQQIHTGEKPYVC--PECGKGFYNKSSLPRHQMTHTRGRSFVCQKCGK 867
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
511-535 5.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.97e-04
                          10        20
                  ....*....|....*....|....*
gi 74196263   511 LKMHRRVHTGEKPYKCRDCGKSFTY 535
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 352-430 1.11e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 352 GEKPYECR--DCGKSFNNTSQLKVHyRIHTGERPYVCPVCGKafkqksilSTHETIHTGEKPYKCTVCGKLFSCTSRLKV 429
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 74196263 430 H 430
Cdd:COG5189 417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
679-703 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*
gi 74196263   679 LKEHLRIHTGETPYACSECGKAFSR 703
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 380-468 1.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 380 GERPYVCPV--CGKAFKQKSILSTHEtIHTGEKPykctvcgKLFSCTSRLKvHYQIHMKEKPYECGDCGKAFKRKSSLtv 457
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHM-LHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGL-- 414

                        90
                ....*....|.
gi 74196263 458 hqKIHIRQTHH 468
Cdd:COG5189 415 --KYHRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
763-785 1.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.61e-03
                          10        20
                  ....*....|....*....|...
gi 74196263   763 LRDHQRIHTGEKPYMCPECGKGF 785
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
623-647 2.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.34e-03
                          10        20
                  ....*....|....*....|....*
gi 74196263   623 LTSHQQTHTGEKPYTCHYCGKSFSH 647
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 772-850 2.36e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263 772 GEKPYMCP--ECGKGFFGRSSL-----HRHQITHTKERPfvcqkcgktfiqksALTSHQQIHTGEKPYVCPECGKGFYNK 844
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLkyhmlHGHQNQKLHENP--------------SPEKMNIFSAKDKPYRCEVCDKRYKNL 411


                ....*.
gi 74196263 845 SSLPRH 850
Cdd:COG5189 412 NGLKYH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 328-350 2.59e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.59e-03
                          10        20
                  ....*....|....*....|...
gi 74196263   328 YECPDCGKSFSRTSNLQVHHRIH 350
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
567-589 2.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.96e-03
                          10        20
                  ....*....|....*....|...
gi 74196263   567 LEEHERIHTGEKPYVCTECGKGF 589
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
735-756 4.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.79e-03
                          10        20
                  ....*....|....*....|..
gi 74196263   735 LRTHQRIHTGEKPYKCSDCGKA 756
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKS 23
PHA00733 PHA00733
hypothetical protein
 663-722 5.00e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 5.00e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 74196263  663 PYKCDYCAKSFSNSSQLKEHLRIhtGETPYACSECGKAFSRRSSlnlhTKIHTGEKHHIC 722
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDS----TLDHVCKKHNIC 126
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 636-658 5.20e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.20e-03
                          10        20
                  ....*....|....*....|...
gi 74196263   636 YTCHYCGKSFSHTSQLTVHHRIH 658
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
818-841 7.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.10e-03
                          10        20
                  ....*....|....*....|....
gi 74196263   818 ALTSHQQIHTGEKPYVCPECGKGF 841
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 440-462 8.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.76e-03
                          10        20
                  ....*....|....*....|...
gi 74196263   440 YECGDCGKAFKRKSSLTVHQKIH 462
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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