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Conserved domains on  [gi|74212121|dbj|BAE40223|]
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unnamed protein product [Mus musculus]

Protein Classification

mS23 family ribosomal protein( domain architecture ID 10564645)

mS23 family ribosomal protein such as mammalian mitochondrial 28S ribosomal protein MRPS23

Gene Ontology:  GO:0003735|GO:0006412
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-130 1.43e-68

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


:

Pssm-ID: 463108  Cd Length: 128  Bit Score: 204.42  E-value: 1.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212121     2 AGSRLETVGSVFSRTRDLMRAGVLK--EKPLWYDIYKAFPPLREPVFRRPRLRYgkaKADIQDIFYQEDQIRAKFFATYG 79
Cdd:pfam10484   1 AGSRLEKFGTIFTRVRDLLRSGVLKeeEKPLWYDVYEAFPPKREPLYNRPAPRI---EDPVREIFYEEDVIRAKFYKVYG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74212121    80 SGQKAFDLFDPNFKSTCQRFVEKYTELQNLGETDEEKLFVETGKALLAEGI 130
Cdd:pfam10484  78 NGPRAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-130 1.43e-68

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 204.42  E-value: 1.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212121     2 AGSRLETVGSVFSRTRDLMRAGVLK--EKPLWYDIYKAFPPLREPVFRRPRLRYgkaKADIQDIFYQEDQIRAKFFATYG 79
Cdd:pfam10484   1 AGSRLEKFGTIFTRVRDLLRSGVLKeeEKPLWYDVYEAFPPKREPLYNRPAPRI---EDPVREIFYEEDVIRAKFYKVYG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74212121    80 SGQKAFDLFDPNFKSTCQRFVEKYTELQNLGETDEEKLFVETGKALLAEGI 130
Cdd:pfam10484  78 NGPRAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
At1g26750 cd23701
Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a ...
 10-107 5.79e-21

Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome.


Pssm-ID: 467914  Cd Length: 83  Bit Score: 81.89  E-value: 5.79e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212121  10 GSVFSRTRDLMRAGVlKEKPLWYDIYKAFPPLREPVFRRPRlrygkakadIQDIFYQEDQIRAKFFATYGsgqkafdlfD 89
Cdd:cd23701   1 GDLLTRVRKLLRGGV-IEKPLWLDAVERFPPPTPPRRNLGK---------PPKITYPEDRLRKKFYKKHP---------E 61

                        90
                ....*....|....*...
gi 74212121  90 PNFKSTCQRFVEKYTELQ 107
Cdd:cd23701  62 EAYDVAEQEFYEERQELE 79
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-130 1.43e-68

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 204.42  E-value: 1.43e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212121     2 AGSRLETVGSVFSRTRDLMRAGVLK--EKPLWYDIYKAFPPLREPVFRRPRLRYgkaKADIQDIFYQEDQIRAKFFATYG 79
Cdd:pfam10484   1 AGSRLEKFGTIFTRVRDLLRSGVLKeeEKPLWYDVYEAFPPKREPLYNRPAPRI---EDPVREIFYEEDVIRAKFYKVYG 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 74212121    80 SGQKAFDLFDPNFKSTCQRFVEKYTELQNLGETDEEKLFVETGKALLAEGI 130
Cdd:pfam10484  78 NGPRAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
At1g26750 cd23701
Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a ...
 10-107 5.79e-21

Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome.


Pssm-ID: 467914  Cd Length: 83  Bit Score: 81.89  E-value: 5.79e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212121  10 GSVFSRTRDLMRAGVlKEKPLWYDIYKAFPPLREPVFRRPRlrygkakadIQDIFYQEDQIRAKFFATYGsgqkafdlfD 89
Cdd:cd23701   1 GDLLTRVRKLLRGGV-IEKPLWLDAVERFPPPTPPRRNLGK---------PPKITYPEDRLRKKFYKKHP---------E 61

                        90
                ....*....|....*...
gi 74212121  90 PNFKSTCQRFVEKYTELQ 107
Cdd:cd23701  62 EAYDVAEQEFYEERQELE 79
MRP-S25 pfam13741
Mitochondrial ribosomal protein S25; This is the family of fungal 37S mitochondrial ribosomal ...
 12-90 6.13e-08

Mitochondrial ribosomal protein S25; This is the family of fungal 37S mitochondrial ribosomal S25 proteins.


Pssm-ID: 433447  Cd Length: 221  Bit Score: 50.32  E-value: 6.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74212121    12 VFSRTRDLMRAGVLKEKPLWYDIYKAFPPL----REPVFR-----RPRLRYGKAKADIQDIF------------------ 64
Cdd:pfam13741   4 VLERTSAYLKSGLLKKKPAWYDVVASIPPStlltRQPPPRsdpstRQRTKTLPGKSNNQGLYktrtnksdrkkknnplfr 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 74212121    65 -----YQEDQIRAKFFAtygsgQKAFDLFDP 90
Cdd:pfam13741  84 ppklkYLEDQLRKQFFR-----DHPWELARP 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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