|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
10-773 |
0e+00 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 1185.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 10 WGEVEDRDGVRLSWNVFPSTRMEASRLVVPIGALYTPLKEKPDTPLLQFDPVSCKQpCRSVLNPYCQVDVRARLWICPFC 89
Cdd:PLN00162 3 FAELEAIDGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPLRCRT-CRAVLNPYCRVDFQAKIWICPFC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 90 LSRNPLPPHYKDITANAIPPELHPSNTTIEYRL---SRPAPAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLPEHALVG 166
Cdd:PLN00162 82 FQRNHFPPHYSSISETNLPAELFPQYTTVEYTLppgSGGAPSPPVFVFVVDTCMIEEELGALKSALLQAIALLPENALVG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 167 LITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLGL-VQPAMRPGMPMQQPGRPFPAGPASRFLLPVSQAEFQLT 245
Cdd:PLN00162 162 LITFGTHVHVHELGFSECSKSYVFRGNKEVSKDQILEQLGLgGKKRRPAGGGIAGARDGLSSSGVNRFLLPASECEFTLN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 246 KAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQNAGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDIDRDNI 325
Cdd:PLN00162 242 SALEELQKDPWPVPPGHRPARCTGAALSVAAGLLGACVPGTGARIMAFVGGPCTEGPGAIVSKDLSEPIRSHKDLDKDAA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 326 KYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMKGLCNSTGGHMILTDSFTSSMFKQSFVRIFEKDADDNLLMG 405
Cdd:PLN00162 322 PYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGHSVFKDSLRRVFERDGEGSLGLS 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 406 FNAVLEVLTTKELKVTGLIGHAVSLNKKSTSVGETECGIGNTCTWKMCGIDPSSSYGIYFEIANQGGpSQNMQSPQKGMM 485
Cdd:PLN00162 402 FNGTFEVNCSKDVKVQGAIGPCASLEKKGPSVSDTEIGEGGTTAWKLCGLDKKTSLAVFFEVANSGQ-SNPQPPGQQFFL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 486 QFLTYYQHSSGHFHLRVTTIARNLSGPAGDPAIAQSFDQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCARFADY 565
Cdd:PLN00162 481 QFLTRYQHSNGQTRLRVTTVTRRWVEGSSSEELVAGFDQEAAAVVMARLASHKMETEEEFDATRWLDRALIRLCSKFGDY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 566 RKDDPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVSNSLIMIQPTLDSYTFDQeGGVPVLLDS 645
Cdd:PLN00162 561 RKDDPSSFRLSPNFSLYPQFMFNLRRSQFVQVFNNSPDETAYFRMMLNRENVTNSLVMIQPTLISYSFNG-PPEPVLLDV 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 646 TSIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENFAALLEQPKEDARDLITDRFPLPRFIVCDQGGSQARFLL 725
Cdd:PLN00162 640 ASIAADRILLLDSYFSVVIFHGSTIAQWRKAGYHNQPEHEAFAQLLEAPQADAQAIIKERFPVPRLVVCDQHGSQARFLL 719
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 74638434 726 SKLNPSTTHTSGAGAYggvgaqSAQTIFTDDVSLQTFMEHLMKLAVSG 773
Cdd:PLN00162 720 AKLNPSATYNSANAMG------GSDIIFTDDVSLQVFMEHLQRLAVQS 761
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
1-774 |
0e+00 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 1076.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 1 MDYEalkeqwgEVEDRDGVRLSWNVFPSTRMEASRLVVPIGALYTPLKEKPDTPLLQFDPVSCKQPCRSVLNPYCQVDVR 80
Cdd:COG5047 1 MNFE-------IIEENDGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCHIDER 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 81 ARLWICPFCLSRNPLPPHYKDITANAIPPELHPSNTTIEYRLSRPAPAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLP 160
Cdd:COG5047 74 NQSWICPFCNQRNTLPPQYRDISNANLPLELLPQSSTIEYTLSKPVILPPVFFFVVDACCDEEELTALKDSLIVSLSLLP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 161 EHALVGLITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLGLVQPAMRPGMPMQQPGRPfpAGPASRFLLPVSQA 240
Cdd:COG5047 154 PEALVGLITYGTSIQVHELNAENHRRSYVFSGNKEYTKENLQELLALSKPTKSGGFESKISGIG--QFASSRFLLPTQQC 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 241 EFQLTKAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQNAGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDI 320
Cdd:COG5047 232 EFKLLNILEQLQPDPWPVPAGKRPLRCTGSALNIASSLLEQCFPNAGCHIVLFAGGPCTVGPGTVVSTELKEPMRSHHDI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 321 DRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMKGLCNSTGGHMILTDSFTSSMFKQSFVRIFEKDADD 400
Cdd:COG5047 312 ESDSAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRIFNRDSEG 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 401 NLLMGFNAVLEVLTTKELKVTGLIGHAVSLNKKSTSVGETECGIGNTCTWKMCGIDPSSSYGIYFEIANQGGpSQNMQSP 480
Cdd:COG5047 392 YLKMGFNANMEVKTSKNLKIKGLIGHAVSVKKKANNISDSEIGIGATNSWKMASLSPKSNYALYFEIALGAA-SGSAQRP 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 481 QKGMMQFLTYYQHSSGHFHLRVTTIARNLSgPAGDPAIAQSFDQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCA 560
Cdd:COG5047 471 AEAYIQFITTYQHSSGTYRIRVTTVARMFT-DGGLPKINRSFDQEAAAVFMARIAAFKAETEDIIDVFRWIDRNLIRLCQ 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 561 RFADYRKDDPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVSNSLIMIQPTLDSYTFdQEGGVP 640
Cdd:COG5047 550 KFADYRKDDPSSFRLDPNFTLYPQFMYHLRRSPFLSVFNNSPDETAFYRHMLNNADVNDSLIMIQPTLQSYSF-EKGGVP 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 641 VLLDSTSIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENFAALLEQPKEDARDLITDRFPLPRFIVCDQGGSQ 720
Cdd:COG5047 629 VLLDSVSVKPDVILLLDTFFHILIFHGSYIAQWRNAGYQEQPEYLNLKELLEAPRLEAAELLQDRFPIPRFIVTEQGGSQ 708
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 74638434 721 ARFLLSKLNPSTTHTSGAGAyggvgaqSAQTIFTDDVSLQTFMEHLMKLAVSGT 774
Cdd:COG5047 709 ARFLLSKINPSDITNKMSGG-------GSETILTDDVNLQKFMNHLRKLAVSKS 755
|
|
| Sec23-like |
cd01478 |
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
127-392 |
5.94e-178 |
|
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 23 is very similar to Sec24. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup lack the consensus MIDAS motif but have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238755 [Multi-domain] Cd Length: 267 Bit Score: 510.38 E-value: 5.94e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 127 PAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLPEHALVGLITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLG 206
Cdd:cd01478 1 TSPPVFLFVVDTCMDEEELDALKESLIMSLSLLPPNALVGLITFGTMVQVHELGFEECSKSYVFRGNKDYTAKQIQDMLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 207 LVQPAMRPGMPM-QQPGRPFPAGPASRFLLPVSQAEFQLTKAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQN 285
Cdd:cd01478 81 LGGPAMRPSASQhPGAGNPLPSAAASRFLLPVSQCEFTLTDLLEQLQPDPWPVPAGHRPLRCTGVALSIAVGLLEACFPN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 286 AGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDIDRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMK 365
Cdd:cd01478 161 TGARIMLFAGGPCTVGPGAVVSTELKDPIRSHHDIDKDNAKYYKKAVKFYDSLAKRLAANGHAVDIFAGCLDQVGLLEMK 240
|
250 260
....*....|....*....|....*..
gi 74638434 366 GLCNSTGGHMILTDSFTSSMFKQSFVR 392
Cdd:cd01478 241 VLVNSTGGHVVLSDSFTTSIFKQSFQR 267
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
127-394 |
3.18e-93 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 291.08 E-value: 3.18e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 127 PAPPIFLYVVDTCQE---EDSLAALKESLIMSLSLLP--EHALVGLITYGTMAQVHEIGYTEcpksyvfRGNKEYAAKQV 201
Cdd:pfam04811 1 PQPPVFLFVIDVSYNaikSGLLAALKESLLQSLDLLPgdPRARVGFITFDSTVHFFNLGSSL-------RQPQMLVVSDL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 202 QEMLGlvqpamrpgmpmqqpgrPFPagpaSRFLLPVSQAEFQLTKAIEQLQKdPWPVagNLRALRCTGVALSVAVGLLET 281
Cdd:pfam04811 74 QDMFL-----------------PLP----DRFLVPLSECRFVLEDLLEQLPP-MFPV--TKRPERCLGPALQAAFLLLKA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 282 SFQnaGGRIMLFAGGPATEGPGMVVGPELREpirSHHDIDRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGL 361
Cdd:pfam04811 130 AFT--GGKIMVFQGGLPTVGPGGKLKSRLDE---SHHGTDKEKAKLVKKADKFYKSLAKECVKQGHSVDLFAFSLDYVDV 204
|
250 260 270
....*....|....*....|....*....|....*..
gi 74638434 362 LEMKGLCNSTGGHMILTDSFT----SSMFKQSFVRIF 394
Cdd:pfam04811 205 ATLGQLSRLTGGQVYLYPSFQadvdGSKFKQDLQRYF 241
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
10-773 |
0e+00 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 1185.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 10 WGEVEDRDGVRLSWNVFPSTRMEASRLVVPIGALYTPLKEKPDTPLLQFDPVSCKQpCRSVLNPYCQVDVRARLWICPFC 89
Cdd:PLN00162 3 FAELEAIDGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPLRCRT-CRAVLNPYCRVDFQAKIWICPFC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 90 LSRNPLPPHYKDITANAIPPELHPSNTTIEYRL---SRPAPAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLPEHALVG 166
Cdd:PLN00162 82 FQRNHFPPHYSSISETNLPAELFPQYTTVEYTLppgSGGAPSPPVFVFVVDTCMIEEELGALKSALLQAIALLPENALVG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 167 LITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLGL-VQPAMRPGMPMQQPGRPFPAGPASRFLLPVSQAEFQLT 245
Cdd:PLN00162 162 LITFGTHVHVHELGFSECSKSYVFRGNKEVSKDQILEQLGLgGKKRRPAGGGIAGARDGLSSSGVNRFLLPASECEFTLN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 246 KAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQNAGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDIDRDNI 325
Cdd:PLN00162 242 SALEELQKDPWPVPPGHRPARCTGAALSVAAGLLGACVPGTGARIMAFVGGPCTEGPGAIVSKDLSEPIRSHKDLDKDAA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 326 KYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMKGLCNSTGGHMILTDSFTSSMFKQSFVRIFEKDADDNLLMG 405
Cdd:PLN00162 322 PYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGHSVFKDSLRRVFERDGEGSLGLS 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 406 FNAVLEVLTTKELKVTGLIGHAVSLNKKSTSVGETECGIGNTCTWKMCGIDPSSSYGIYFEIANQGGpSQNMQSPQKGMM 485
Cdd:PLN00162 402 FNGTFEVNCSKDVKVQGAIGPCASLEKKGPSVSDTEIGEGGTTAWKLCGLDKKTSLAVFFEVANSGQ-SNPQPPGQQFFL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 486 QFLTYYQHSSGHFHLRVTTIARNLSGPAGDPAIAQSFDQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCARFADY 565
Cdd:PLN00162 481 QFLTRYQHSNGQTRLRVTTVTRRWVEGSSSEELVAGFDQEAAAVVMARLASHKMETEEEFDATRWLDRALIRLCSKFGDY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 566 RKDDPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVSNSLIMIQPTLDSYTFDQeGGVPVLLDS 645
Cdd:PLN00162 561 RKDDPSSFRLSPNFSLYPQFMFNLRRSQFVQVFNNSPDETAYFRMMLNRENVTNSLVMIQPTLISYSFNG-PPEPVLLDV 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 646 TSIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENFAALLEQPKEDARDLITDRFPLPRFIVCDQGGSQARFLL 725
Cdd:PLN00162 640 ASIAADRILLLDSYFSVVIFHGSTIAQWRKAGYHNQPEHEAFAQLLEAPQADAQAIIKERFPVPRLVVCDQHGSQARFLL 719
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 74638434 726 SKLNPSTTHTSGAGAYggvgaqSAQTIFTDDVSLQTFMEHLMKLAVSG 773
Cdd:PLN00162 720 AKLNPSATYNSANAMG------GSDIIFTDDVSLQVFMEHLQRLAVQS 761
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
1-774 |
0e+00 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 1076.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 1 MDYEalkeqwgEVEDRDGVRLSWNVFPSTRMEASRLVVPIGALYTPLKEKPDTPLLQFDPVSCKQPCRSVLNPYCQVDVR 80
Cdd:COG5047 1 MNFE-------IIEENDGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKCTAPCKAVLNPYCHIDER 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 81 ARLWICPFCLSRNPLPPHYKDITANAIPPELHPSNTTIEYRLSRPAPAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLP 160
Cdd:COG5047 74 NQSWICPFCNQRNTLPPQYRDISNANLPLELLPQSSTIEYTLSKPVILPPVFFFVVDACCDEEELTALKDSLIVSLSLLP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 161 EHALVGLITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLGLVQPAMRPGMPMQQPGRPfpAGPASRFLLPVSQA 240
Cdd:COG5047 154 PEALVGLITYGTSIQVHELNAENHRRSYVFSGNKEYTKENLQELLALSKPTKSGGFESKISGIG--QFASSRFLLPTQQC 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 241 EFQLTKAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQNAGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDI 320
Cdd:COG5047 232 EFKLLNILEQLQPDPWPVPAGKRPLRCTGSALNIASSLLEQCFPNAGCHIVLFAGGPCTVGPGTVVSTELKEPMRSHHDI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 321 DRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMKGLCNSTGGHMILTDSFTSSMFKQSFVRIFEKDADD 400
Cdd:COG5047 312 ESDSAQHSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRIFNRDSEG 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 401 NLLMGFNAVLEVLTTKELKVTGLIGHAVSLNKKSTSVGETECGIGNTCTWKMCGIDPSSSYGIYFEIANQGGpSQNMQSP 480
Cdd:COG5047 392 YLKMGFNANMEVKTSKNLKIKGLIGHAVSVKKKANNISDSEIGIGATNSWKMASLSPKSNYALYFEIALGAA-SGSAQRP 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 481 QKGMMQFLTYYQHSSGHFHLRVTTIARNLSgPAGDPAIAQSFDQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCA 560
Cdd:COG5047 471 AEAYIQFITTYQHSSGTYRIRVTTVARMFT-DGGLPKINRSFDQEAAAVFMARIAAFKAETEDIIDVFRWIDRNLIRLCQ 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 561 RFADYRKDDPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNHEDVSNSLIMIQPTLDSYTFdQEGGVP 640
Cdd:COG5047 550 KFADYRKDDPSSFRLDPNFTLYPQFMYHLRRSPFLSVFNNSPDETAFYRHMLNNADVNDSLIMIQPTLQSYSF-EKGGVP 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 641 VLLDSTSIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENFAALLEQPKEDARDLITDRFPLPRFIVCDQGGSQ 720
Cdd:COG5047 629 VLLDSVSVKPDVILLLDTFFHILIFHGSYIAQWRNAGYQEQPEYLNLKELLEAPRLEAAELLQDRFPIPRFIVTEQGGSQ 708
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 74638434 721 ARFLLSKLNPSTTHTSGAGAyggvgaqSAQTIFTDDVSLQTFMEHLMKLAVSGT 774
Cdd:COG5047 709 ARFLLSKINPSDITNKMSGG-------GSETILTDDVNLQKFMNHLRKLAVSKS 755
|
|
| Sec23-like |
cd01478 |
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
127-392 |
5.94e-178 |
|
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 23 is very similar to Sec24. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup lack the consensus MIDAS motif but have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238755 [Multi-domain] Cd Length: 267 Bit Score: 510.38 E-value: 5.94e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 127 PAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLPEHALVGLITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLG 206
Cdd:cd01478 1 TSPPVFLFVVDTCMDEEELDALKESLIMSLSLLPPNALVGLITFGTMVQVHELGFEECSKSYVFRGNKDYTAKQIQDMLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 207 LVQPAMRPGMPM-QQPGRPFPAGPASRFLLPVSQAEFQLTKAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQN 285
Cdd:cd01478 81 LGGPAMRPSASQhPGAGNPLPSAAASRFLLPVSQCEFTLTDLLEQLQPDPWPVPAGHRPLRCTGVALSIAVGLLEACFPN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 286 AGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDIDRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMK 365
Cdd:cd01478 161 TGARIMLFAGGPCTVGPGAVVSTELKDPIRSHHDIDKDNAKYYKKAVKFYDSLAKRLAANGHAVDIFAGCLDQVGLLEMK 240
|
250 260
....*....|....*....|....*..
gi 74638434 366 GLCNSTGGHMILTDSFTSSMFKQSFVR 392
Cdd:cd01478 241 VLVNSTGGHVVLSDSFTTSIFKQSFQR 267
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
127-394 |
3.18e-93 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 291.08 E-value: 3.18e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 127 PAPPIFLYVVDTCQE---EDSLAALKESLIMSLSLLP--EHALVGLITYGTMAQVHEIGYTEcpksyvfRGNKEYAAKQV 201
Cdd:pfam04811 1 PQPPVFLFVIDVSYNaikSGLLAALKESLLQSLDLLPgdPRARVGFITFDSTVHFFNLGSSL-------RQPQMLVVSDL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 202 QEMLGlvqpamrpgmpmqqpgrPFPagpaSRFLLPVSQAEFQLTKAIEQLQKdPWPVagNLRALRCTGVALSVAVGLLET 281
Cdd:pfam04811 74 QDMFL-----------------PLP----DRFLVPLSECRFVLEDLLEQLPP-MFPV--TKRPERCLGPALQAAFLLLKA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 282 SFQnaGGRIMLFAGGPATEGPGMVVGPELREpirSHHDIDRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGL 361
Cdd:pfam04811 130 AFT--GGKIMVFQGGLPTVGPGGKLKSRLDE---SHHGTDKEKAKLVKKADKFYKSLAKECVKQGHSVDLFAFSLDYVDV 204
|
250 260 270
....*....|....*....|....*....|....*..
gi 74638434 362 LEMKGLCNSTGGHMILTDSFT----SSMFKQSFVRIF 394
Cdd:pfam04811 205 ATLGQLSRLTGGQVYLYPSFQadvdGSKFKQDLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
127-392 |
2.70e-86 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 272.97 E-value: 2.70e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 127 PAPPIFLYVVDTCQE---EDSLAALKESLIMSLSLLP--EHALVGLITYGTMAQVHEIGYTEC-PKSYVFRGNKEyaakq 200
Cdd:cd01468 1 PQPPVFVFVIDVSYEaikEGLLQALKESLLASLDLLPgdPRARVGLITYDSTVHFYNLSSDLAqPKMYVVSDLKD----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 201 vqemlglvqpamrpgmpmqqpgrPFPAGPaSRFLLPVSQAEFQLTKAIEQLQKDPWPVAGnLRALRCTGVALSVAVGLLE 280
Cdd:cd01468 76 -----------------------VFLPLP-DRFLVPLSECKKVIHDLLEQLPPMFWPVPT-HRPERCLGPALQAAFLLLK 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 281 TSFqnAGGRIMLFAGGPATEGPGMVVGPELREPIRSHhdidrDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVG 360
Cdd:cd01468 131 GTF--AGGRIIVFQGGLPTVGPGKLKSREDKEPIRSH-----DEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVD 203
|
250 260 270
....*....|....*....|....*....|....*.
gi 74638434 361 LLEMKGLCNSTGGHMILTDSF----TSSMFKQSFVR 392
Cdd:cd01468 204 VATLKQLAKSTGGQVYLYDSFqapnDGSKFKQDLQR 239
|
|
| Sec23_C |
cd11287 |
C-terminal Actin depolymerization factor-homology domain of Sec23; The C-terminal domain of ... |
615-736 |
9.48e-75 |
|
C-terminal Actin depolymerization factor-homology domain of Sec23; The C-terminal domain of the Sec23 subunit of the coat protein complex II (COPII) is distantly related to gelsolin-like repeats and the actin depolymerizing domains found in cofilin and similar proteins. Sec23 forms a tight complex with Sec24. The cytoplasmic Sec23/24 complex is recruited together with Sar1-GTP and Sec13/31 to induce coat polymerization and membrane deformation in the forming of COPII-coated endoplasmic reticulum vesicles. The function of the Sec23 C-terminal domain is unclear.
Pssm-ID: 200443 [Multi-domain] Cd Length: 121 Bit Score: 238.04 E-value: 9.48e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 615 EDVSNSLIMIQPTLDSYTFdQEGGVPVLLDSTSIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENFAALLEQP 694
Cdd:cd11287 1 EDVSNSLIMIQPTLYSYSF-NGPPEPVLLDSSSILPDRILLLDTFFHILIYHGETIAQWRKAGYQDQPEYENFKDLLEAP 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 74638434 695 KEDARDLITDRFPLPRFIVCDQGGSQARFLLSKLNPSTTHTS 736
Cdd:cd11287 80 VDDAQELLQDRFPMPRYIVTEQGGSQARFLLSKVNPSQTHNN 121
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
523-622 |
6.22e-32 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 119.53 E-value: 6.22e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 523 DQEAAAVLMSRIAVFKAEVDDGPDVLRWVDRMLIRLCARFADYRKD--DPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNN 600
Cdd:pfam04815 1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASssSPGQLILPESLKLLPLYMLALLKSPALRGGNS 80
|
90 100
....*....|....*....|...
gi 74638434 601 SP-DETAFYRHVLNHEDVSNSLI 622
Cdd:pfam04815 81 SPsDERAYARHLLLSLPVEELLL 103
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
405-510 |
2.35e-27 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 106.08 E-value: 2.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 405 GFNAVLEVLTTKELKVTGLIGHAVSLNkkstsvgetecgigNTCTWKMCGIDPSSSYGIYFEIanqggpSQNMQSPQKGM 484
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRS--------------SGDTWKLPSLDPDTSYAFEFDI------DEPLPNGSNAY 60
|
90 100
....*....|....*....|....*.
gi 74638434 485 MQFLTYYQHSSGHFHLRVTTIARNLS 510
Cdd:pfam08033 61 IQFALLYTHSSGERRIRVTTVALPVT 86
|
|
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
14-668 |
1.01e-17 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 87.92 E-value: 1.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 14 EDRDGVRLSWNVFPSTR--MEASRLvvPIGAL---YTPLKEKPDTPLLQFD--PVSCKQpCRSVLNPYCQVDVRARLWIC 86
Cdd:COG5028 148 CSPKYVRSTMYAIPETNdlLKKSKI--PFGLVirpFLELYPEEDPVPLVEDgsIVRCRR-CRSYINPFVQFIEQGRKWRC 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 87 PFCLSRNPLPPHYKDITANAIP-------PELhpSNTTI------EYRLSrpAPAPPIFLYVVDTCQEEDS---LAALKE 150
Cdd:COG5028 225 NICRSKNDVPEGFDNPSGPNDPrsdrysrPEL--KSGVVdflapkEYSLR--QPPPPVYVFLIDVSFEAIKnglVKAAIR 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 151 SLIMSLSLLPEHalvglitygtmaqvheigytecpksyvfRGNKEYAAKQVQEMLGLVQPamRPGMPMQQ-----PGRPF 225
Cdd:COG5028 301 AILENLDQIPNF----------------------------DPRTKIAIICFDSSLHFFKL--SPDLDEQMlivsdLDEPF 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 226 PAGPASRFLLPVS---QAEFQLTKAIEQL---QKDPWPVAGNlralrctgvALSVAVGLLEtsfqNAGGRIMLFAGGPAT 299
Cdd:COG5028 351 LPFPSGLFVLPLKsckQIIETLLDRVPRIfqdNKSPKNALGP---------ALKAAKSLIG----GTGGKIIVFLSTLPN 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 300 EGPGMVvgpELREPIRSHHDIDRDnikyykkalKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMKGLCNSTGG------ 373
Cdd:COG5028 418 MGIGKL---QLREDKESSLLSCKD---------SFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGqtyfyp 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 374 HMILTDSFTSSMFKQSFVRIFEKDaddnllMGFNAVLEVLTTKELKVTGLIGHavSLNKKStsvgeTECGIGNtctwkmc 453
Cdd:COG5028 486 NFSATRPNDATKLANDLVSHLSME------IGYEAVMRVRCSTGLRVSSFYGN--FFNRSS-----DLCAFST------- 545
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 454 gIDPSSSYGIYFEIanqggpSQNMQSPqKGMMQFLTYYQHSSGHFHLRVTTIARNLSGPAGDpaIAQSFDQEAAAVLMSR 533
Cdd:COG5028 546 -MPRDTSLLVEFSI------DEKLMTS-DVYFQVALLYTLNDGERRIRVVNLSLPTSSSIRE--VYASADQLAIACILAK 615
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 534 IAVFKAEVDDGPDVLRWVDRMLIRLcarFADYRKD-----DPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFY 608
Cdd:COG5028 616 KASTKALNSSLKEARVLINKSMVDI---LKAYKKElvksnTSTQLPLPANLKLLPLLMLALLKSSAFRSGSTPSDIRISA 692
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74638434 609 RHVLNHEDVSNSLIMIQPTLDSYT-FDQEGGVPVLLDSTSIQP---TH-------ILLLDTFFHILIFHGE 668
Cdd:COG5028 693 LNRLTSLPLKQLMRNIYPTLYALHdMPIEAGLPDEGLLVLPSPinaTSsllesggLYLIDTGQKIFLWFGK 763
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
60-98 |
4.09e-16 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 72.48 E-value: 4.09e-16
10 20 30
....*....|....*....|....*....|....*....
gi 74638434 60 PVSCKQpCRSVLNPYCQVDVRARLWICPFCLSRNPLPPH 98
Cdd:pfam04810 1 PVRCRR-CRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
639-724 |
2.25e-13 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 65.79 E-value: 2.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 639 VPVLLDSTSIQPTHILLLDTFFHILIfhgetiaeWRkaGYQDQEGYENFAALLEQPKEDardliTDRFPLPRFIVCDQGG 718
Cdd:pfam00626 6 PPVPLSQESLNSGDCYLLDNGFTIFL--------WV--GKGSSLLEKLFAALLAAQLDD-----DERFPLPEVIRVPQGK 70
|
....*.
gi 74638434 719 SQARFL 724
Cdd:pfam00626 71 EPARFL 76
|
|
| gelsolin_like |
cd11280 |
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ... |
639-724 |
2.27e-05 |
|
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.
Pssm-ID: 200436 Cd Length: 88 Bit Score: 43.51 E-value: 2.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74638434 639 VPVLLDSTSIQPTHILLLDTFFHILIFHGE--TIAEWrkagyqdqegyeNFAALLeqpkedARDLITDRFPLPRFIVCDQ 716
Cdd:cd11280 16 EEVPLASSSLDSDDVFVLDTGSEIYIWQGRasSQAEL------------AAAALL------AKELDEERKGKPEIVRIRQ 77
|
....*...
gi 74638434 717 GGSQARFL 724
Cdd:cd11280 78 GQEPREFW 85
|
|
| |
