NCBI Conserved Domain Search

first PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar proteins; ...

268-397

6.51e-91

first PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar proteins; NSD3, also called histone-lysine N-methyltransferase NSD3, protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant-homeodomain (PHD) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions. This model corresponds to the first PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438991 Cd Length: 130 Bit Score: 289.53 E-value: 6.51e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQA 347
Cdd:cd20163    1 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSSQPERAWVHEKRVREYKGHKQYEELLAEATKQA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 74761342  348 SNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDK 397
Cdd:cd20163   81 SNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDK 130

PWWP_NSD3_rpt2

second PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar ...

959-1053

2.92e-71

second PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar proteins; NSD3, also called histone-lysine N-methyltransferase NSD3, protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant-homeodomain (PHD) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions. This model corresponds to the second PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438994 Cd Length: 95 Bit Score: 232.56 E-value: 2.92e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  959 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFK 1038
Cdd:cd20166    1 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFK 80

                         90
                 ....*....|....*
gi 74761342 1039 KALEEAAKRFQELKA 1053
Cdd:cd20166   81 KALEEAAKRFQELKA 95

C5HCH

pfam17982

NSD Cys-His rich domain; This is an NSD-specific Cys-His rich region (C5HCH) domain. Family ...

1364-1413

5.70e-30

NSD Cys-His rich domain; This is an NSD-specific Cys-His rich region (C5HCH) domain. Family members include NSD3 (nuclear receptor SET domain-containing) proteins. This domain is located on the C-terminal of NSD1, 2 and 3 proteins. C5HCH domain lies adjacent to the fifth plant homeodomain (PHD5). The PHD5-C5HCH module of NSD3 (PHD5-C5HCHNSD3) recognizes the H3 N-terminal peptide containing unmodified K4 and trimethylated K9. Moreover, it has been reported that the PHD5-C5HCH module of NSD1 (PHD5-C5HCH) was the sole region required for tight binding of the NUP98-NSD1 fusion protein to the HoxA9 gene promoter, implicating that PHD5-C5HCH might have chromatin targeting ability.

Pssm-ID: 465605 Cd Length: 50 Bit Score: 112.95 E-value: 5.70e-30

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74761342   1364 WHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP 1413
Cdd:pfam17982    1 WHQCSVCGSPATSFCEFCPSSFCKDHEKGALVPSALEGRLCCSEHDPESP 50

PHD3_NSD3

cd15655

PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

798-850

8.25e-29

PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed histone-lysine N-methyltransferase NSD3, or protein whistle, or WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant homeodomain (PHD) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the third PHD finger.

Pssm-ID: 277125 Cd Length: 53 Bit Score: 109.59 E-value: 8.25e-29

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74761342  798 CCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNH 850
Cdd:cd15655    1 CCTTCSMDKDIHKASKGRMMRCLRCPVAYHTGDGCVAAGSVLVTPHIIICSNH 53

PHD5_NSD3

cd15661

PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

1323-1365

6.71e-28

PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed histone-lysine N-methyltransferase NSD3, or protein whistle, or WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant-homeodomain (PHD) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the fifth PHD finger.

Pssm-ID: 277131 Cd Length: 43 Bit Score: 106.98 E-value: 6.71e-28

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 1365
Cdd:cd15661    1 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 43

PHD2_NSD3

cd15652

PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

751-797

2.57e-24

PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed histone-lysine N-methyltransferase NSD3, or protein whistle, or WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant homeodomain (PHD) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the second PHD finger.

Pssm-ID: 277122 Cd Length: 47 Bit Score: 96.86 E-value: 2.57e-24

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 74761342  751 PCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQH 797
Cdd:cd15652    1 PCFSCKVPGKDVKRCSVNACGRFYHEACVRKYTTSAFESKGFRCPQH 47

PHD1_NSD3

cd15649

PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

703-746

5.53e-21

PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed histone-lysine N-methyltransferase NSD3, or protein whistle, or WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant-homeodomain (PHD) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the first PHD finger.

Pssm-ID: 277119 Cd Length: 44 Bit Score: 87.13 E-value: 5.53e-21

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 74761342  703 VCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECK 746
Cdd:cd15649    1 VCQVCESFGESLVTCEGECCGLFHLECLGLTSLPDEKFICQECK 44

PHD4_NSD3

PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

917-952

1.60e-19

PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed histone-lysine N-methyltransferase NSD3, or protein whistle, or WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, or Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1, or WHSC1L1), is a lysine methyltransferase encoded by gene NSD3, which is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD3 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, five plant-homeodomain (PHD) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the fourth PHD finger.

Pssm-ID: 277128 Cd Length: 40 Bit Score: 83.04 E-value: 1.60e-19

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDC 952
Cdd:cd15658    5 CARGGRLLCCESCPASFHPECLSIEMPEGCWNCNEC 40

AWS

pfam17907

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc ...

1104-1142

6.32e-14

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc binding domain. The full AWS domain contains 8 cysteines. This entry represents the N-terminal part of the domain, with the C-terminal part interwoven with the SET domain.

Pssm-ID: 465559 Cd Length: 39 Bit Score: 67.07 E-value: 6.32e-14

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 74761342   1104 DENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKR 1142
Cdd:pfam17907    1 DDPPCGCGSDCINRMLFVECTPKTCPCGESCQNQRFQRK 39

TNG2 super family

cl34876

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

602-746

1.83e-03

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

The actual alignment was detected with superfamily member COG5034:

Pssm-ID: 227367 [Multi-domain] Cd Length: 271 Bit Score: 41.85 E-value: 1.83e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  602 EQVETVPQATvkTGLQKGASEISDSCKPLKKRSRASTDVEMTSSA----------YRDTSDSDSRGLSDLQVgfgkqvdS 671
Cdd:COG5034  117 ARIENCHDAV--SRLERNSYSSAARRSSGEHRSAASSQGSRHTKLkkrknihnlkRRSPELSSKREVSFTLE-------S 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  672 PSATADADVSDVQSMDSSLSRRG---TGMSKKDTVCQICES-SGDSLIPCEGECCKH--FHLECLGLASLPDSKFICMEC 745
Cdd:COG5034  188 PSVPDTATRVKEGNNGGSTKSRGvssEDNSEGEELYCFCQQvSYGQMVACDNANCKRewFHLECVGLKEPPKGKWYCPEC 267


                 .
gi 74761342  746 K 746
Cdd:COG5034  268 K 268

Name

Accession

Description

Interval

E-value

SET_NSD3

cd19212

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

1144-1285

4.65e-104

Pssm-ID: 380989 [Multi-domain] Cd Length: 142 Bit Score: 326.88 E-value: 4.65e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1144 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 1223
Cdd:cd19212    1 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342 1224 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 1285
Cdd:cd19212   81 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 142

PWWP_NSD3_rpt1

first PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar proteins; ...

268-397

6.51e-91

Pssm-ID: 438991 Cd Length: 130 Bit Score: 289.53 E-value: 6.51e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQA 347
Cdd:cd20163    1 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSSQPERAWVHEKRVREYKGHKQYEELLAEATKQA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 74761342  348 SNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDK 397
Cdd:cd20163   81 SNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDK 130

PWWP_NSD3_rpt2

second PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar ...

959-1053

2.92e-71

Pssm-ID: 438994 Cd Length: 95 Bit Score: 232.56 E-value: 2.92e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  959 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFK 1038
Cdd:cd20166    1 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFK 80

                         90
                 ....*....|....*
gi 74761342 1039 KALEEAAKRFQELKA 1053
Cdd:cd20166   81 KALEEAAKRFQELKA 95

SET

smart00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...

1145-1268

6.58e-42

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues

Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 149.79 E-value: 6.58e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342    1145 PDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNH 1224
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 74761342    1225 SCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGN 1268
Cdd:smart00317   81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124

SET

COG2940

SET domain-containing protein (function unknown) [General function prediction only];

1142-1282

8.00e-32

SET domain-containing protein (function unknown) [General function prediction only];

Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 121.22 E-value: 8.00e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1142 RLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRlriKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRF 1221
Cdd:COG2940    3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAE---RREPHKEPLHTYLFELDDDGVIDGALGGNPARF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74761342 1222 MNHSCNPNCEtqkWTVNGDvRVGLFALCDIPAGMELTFNYNLDClGNGRTECHCgaDNCSG 1282
Cdd:COG2940   80 INHSCDPNCE---ADEEDG-RIFIVALRDIAAGEELTYDYGLDY-DEEEYPCRC--PNCRG 133

C5HCH

pfam17982

NSD Cys-His rich domain; This is an NSD-specific Cys-His rich region (C5HCH) domain. Family ...

1364-1413

5.70e-30

Pssm-ID: 465605 Cd Length: 50 Bit Score: 112.95 E-value: 5.70e-30

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74761342   1364 WHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP 1413
Cdd:pfam17982    1 WHQCSVCGSPATSFCEFCPSSFCKDHEKGALVPSALEGRLCCSEHDPESP 50

SET

pfam00856

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...

1156-1262

2.80e-29

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.

Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 113.39 E-value: 2.80e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342   1156 GWGLRTKRSIKKGEFVNEYVGE-LIDEEECRLRIKR---AHENSVTNFYMLTVTKD--RIID--AGPKGNYSRFMNHSCN 1227
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLyydKLELRLWGPYLFTLDEDseYCIDarALYYGNWARFINHSCD 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 74761342   1228 PNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1262
Cdd:pfam00856   81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115

PHD3_NSD3

cd15655

PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

798-850

8.25e-29

Pssm-ID: 277125 Cd Length: 53 Bit Score: 109.59 E-value: 8.25e-29

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74761342  798 CCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNH 850
Cdd:cd15655    1 CCTTCSMDKDIHKASKGRMMRCLRCPVAYHTGDGCVAAGSVLVTPHIIICSNH 53

PWWP

PWWP domain; The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain ...

962-1049

4.83e-28

PWWP domain; The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyzes all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.

Pssm-ID: 459964 [Multi-domain] Cd Length: 92 Bit Score: 109.05 E-value: 4.83e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342    962 QIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFA---EGQTSINKTFK 1038
Cdd:pfam00855    2 DLVWAKLKGYPWWPARVVDPEELPENVLKPKKKDGEYLVRFFGDSEFAWVKPKDLKPFDEGDEFEYlkkKKKKKKKKAFK 81

                           90
                   ....*....|.
gi 74761342   1039 KALEEAAKRFQ 1049
Cdd:pfam00855   82 KALEEAEEALK 92

PHD5_NSD3

cd15661

PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

1323-1365

6.71e-28

Pssm-ID: 277131 Cd Length: 43 Bit Score: 106.98 E-value: 6.71e-28

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 1365
Cdd:cd15661    1 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 43

PHD2_NSD3

cd15652

PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

751-797

2.57e-24

Pssm-ID: 277122 Cd Length: 47 Bit Score: 96.86 E-value: 2.57e-24

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 74761342  751 PCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQH 797
Cdd:cd15652    1 PCFSCKVPGKDVKRCSVNACGRFYHEACVRKYTTSAFESKGFRCPQH 47

PHD1_NSD3

cd15649

PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

703-746

5.53e-21

Pssm-ID: 277119 Cd Length: 44 Bit Score: 87.13 E-value: 5.53e-21

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 74761342  703 VCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECK 746
Cdd:cd15649    1 VCQVCESFGESLVTCEGECCGLFHLECLGLTSLPDEKFICQECK 44

PWWP

PWWP domain; The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain ...

271-348

8.10e-21

Pssm-ID: 459964 [Multi-domain] Cd Length: 92 Bit Score: 88.25 E-value: 8.10e-21

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74761342    271 GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNqPERAWVHEKRVREYKGHKQYEELLAEATKQAS 348
Cdd:pfam00855    1 GDLVWAKLKGYPWWPARVVDPEELPENVLKPKKKDGEYLVRFFGD-SEFAWVKPKDLKPFDEGDEFEYLKKKKKKKKK 77

PHD4_NSD3

PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

917-952

1.60e-19

Pssm-ID: 277128 Cd Length: 40 Bit Score: 83.04 E-value: 1.60e-19

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDC 952
Cdd:cd15658    5 CARGGRLLCCESCPASFHPECLSIEMPEGCWNCNEC 40

PWWP

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

958-1019

4.68e-19

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

Pssm-ID: 214603 [Multi-domain] Cd Length: 63 Bit Score: 82.39 E-value: 4.68e-19

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342     958 LHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPY 1019
Cdd:smart00293    1 FKPGDLVWAKMKGFPWWPALVISPKMTPDNIMKRKSDENLYPVLFFGDKDTAWIPSSKLFPL 62

AWS

pfam17907

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc ...

1104-1142

6.32e-14

Pssm-ID: 465559 Cd Length: 39 Bit Score: 67.07 E-value: 6.32e-14

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 74761342   1104 DENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKR 1142
Cdd:pfam17907    1 DDPPCGCGSDCINRMLFVECTPKTCPCGESCQNQRFQRK 39

PWWP

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

268-330

2.50e-12

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

Pssm-ID: 214603 [Multi-domain] Cd Length: 63 Bit Score: 63.13 E-value: 2.50e-12

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74761342     268 FQVGDLVWSKVGTYPWWPCMVssDPQLEVHTKINTRGARE--YHVQFFSNqPERAWVHEKRVREY 330
Cdd:smart00293    1 FKPGDLVWAKMKGFPWWPALV--ISPKMTPDNIMKRKSDEnlYPVLFFGD-KDTAWIPSSKLFPL 62

AWS

smart00570

associated with SET domains; subdomain of PRESET

1094-1144

3.02e-10

associated with SET domains; subdomain of PRESET

Pssm-ID: 197795 Cd Length: 50 Bit Score: 57.02 E-value: 3.02e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 74761342    1094 EIPRCNCKP--ADENPCGleSECLNRMLQYEChPQVCPAGDRCQNQCFTKRLY 1144
Cdd:smart00570    1 DIMTCECKPtdDDETACG--SDCLNRMLFIEC-SSSCPCGSYCSNQRFQKRQY 50

PHD

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...

915-953

1.68e-05

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.

Pssm-ID: 425785 [Multi-domain] Cd Length: 51 Bit Score: 43.63 E-value: 1.68e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 74761342    915 KKCEKGGRLLCCESCPASFHPECLSI-----EMPEGCWNCNDCK 953
Cdd:pfam00628    6 GKSDDGGELVQCDGCDDWFHLACLGPpldpaEIPSGEWLCPECK 49

PHD

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...

915-952

2.55e-05

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger. It is not yet known if PHD fingers have a common molecular function. Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. Other reports suggesting that the PHD finger is a ubiquitin ligase have been refuted as these domains were RING fingers misidentified as PHD fingers.

Pssm-ID: 214584 [Multi-domain] Cd Length: 47 Bit Score: 42.97 E-value: 2.55e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 74761342     915 KKCEKGGRLLCCESCPASFHPECLSI----EMPEGCWNCNDC 952
Cdd:smart00249    6 GKPDDGGELLQCDGCDRWYHQTCLGPplleEEPDGKWYCPKC 47

PHD

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...

1323-1373

6.32e-05

Pssm-ID: 425785 [Multi-domain] Cd Length: 51 Bit Score: 41.71 E-value: 6.32e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 74761342   1323 YCFQCG---DGGELVMCDkkDCPKAYHLLCLNLTQPPYGKWECPWhQCDECSSA 1373
Cdd:pfam00628    1 YCAVCGksdDGGELVQCD--GCDDWFHLACLGPPLDPAEIPSGEW-LCPECKPK 51

PHD

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...

1323-1365

6.48e-05

Pssm-ID: 214584 [Multi-domain] Cd Length: 47 Bit Score: 41.81 E-value: 6.48e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 74761342    1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLNLT---QPPYGKWECPWH 1365
Cdd:smart00249    4 VCGKPDDGGELLQCDG--CDRWYHQTCLGPPlleEEPDGKWYCPKC 47

PHD

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...

703-745

3.19e-04

Pssm-ID: 214584 [Multi-domain] Cd Length: 47 Bit Score: 39.89 E-value: 3.19e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 74761342     703 VCQICESSGDS--LIPCEGeCCKHFHLECLGLA---SLPDSKFICMEC 745
Cdd:smart00249    1 YCSVCGKPDDGgeLLQCDG-CDRWYHQTCLGPPlleEEPDGKWYCPKC 47

PHD

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...

703-746

4.80e-04

Pssm-ID: 425785 [Multi-domain] Cd Length: 51 Bit Score: 39.40 E-value: 4.80e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74761342    703 VCQICESSGDS--LIPCEGeCCKHFHLECLGL----ASLPDSKFICMECK 746
Cdd:pfam00628    1 YCAVCGKSDDGgeLVQCDG-CDDWFHLACLGPpldpAEIPSGEWLCPECK 49

TNG2

COG5034

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

602-746

1.83e-03

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

Pssm-ID: 227367 [Multi-domain] Cd Length: 271 Bit Score: 41.85 E-value: 1.83e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  602 EQVETVPQATvkTGLQKGASEISDSCKPLKKRSRASTDVEMTSSA----------YRDTSDSDSRGLSDLQVgfgkqvdS 671
Cdd:COG5034  117 ARIENCHDAV--SRLERNSYSSAARRSSGEHRSAASSQGSRHTKLkkrknihnlkRRSPELSSKREVSFTLE-------S 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  672 PSATADADVSDVQSMDSSLSRRG---TGMSKKDTVCQICES-SGDSLIPCEGECCKH--FHLECLGLASLPDSKFICMEC 745
Cdd:COG5034  188 PSVPDTATRVKEGNNGGSTKSRGvssEDNSEGEELYCFCQQvSYGQMVACDNANCKRewFHLECVGLKEPPKGKWYCPEC 267


                 .
gi 74761342  746 K 746
Cdd:COG5034  268 K 268

Name

Accession

Description

Interval

E-value

SET_NSD3

cd19212

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

1144-1285

4.65e-104

Pssm-ID: 380989 [Multi-domain] Cd Length: 142 Bit Score: 326.88 E-value: 4.65e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1144 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 1223
Cdd:cd19212    1 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342 1224 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 1285
Cdd:cd19212   81 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 142

SET_NSD

cd19173

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...

1144-1285

3.76e-101

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.

Pssm-ID: 380950 [Multi-domain] Cd Length: 142 Bit Score: 318.88 E-value: 3.76e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1144 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 1223
Cdd:cd19173    1 YPPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITNFYMLTLDKDRIIDAGPKGNLSRFMN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342 1224 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 1285
Cdd:cd19173   81 HSCQPNCETQKWTVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKKVCRCGAPNCSGFLG 142

PWWP_NSD3_rpt1

first PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar proteins; ...

268-397

6.51e-91

Pssm-ID: 438991 Cd Length: 130 Bit Score: 289.53 E-value: 6.51e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQA 347
Cdd:cd20163    1 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSSQPERAWVHEKRVREYKGHKQYEELLAEATKQA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 74761342  348 SNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDK 397
Cdd:cd20163   81 SNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDK 130

SET_NSD2

cd19211

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...

1144-1285

4.40e-89

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).

Pssm-ID: 380988 [Multi-domain] Cd Length: 142 Bit Score: 284.96 E-value: 4.40e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1144 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 1223
Cdd:cd19211    1 YPETKIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342 1224 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 1285
Cdd:cd19211   81 HSCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGAPNCSGFLG 142

SET_NSD1

cd19210

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...

1144-1285

4.20e-87

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.

Pssm-ID: 380987 [Multi-domain] Cd Length: 142 Bit Score: 279.50 E-value: 4.20e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1144 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 1223
Cdd:cd19210    1 YPEVEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342 1224 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 1285
Cdd:cd19210   81 HCCQPNCETQKWTVNGDTRVGLFALCDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLG 142

PWWP_NSD3_rpt2

second PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar ...

959-1053

2.92e-71

Pssm-ID: 438994 Cd Length: 95 Bit Score: 232.56 E-value: 2.92e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  959 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFK 1038
Cdd:cd20166    1 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFK 80

                         90
                 ....*....|....*
gi 74761342 1039 KALEEAAKRFQELKA 1053
Cdd:cd20166   81 KALEEAAKRFQELKA 95

SET_SETD2

cd19172

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...

1144-1285

1.20e-64

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.

Pssm-ID: 380949 [Multi-domain] Cd Length: 142 Bit Score: 215.52 E-value: 1.20e-64

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1144 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 1223
Cdd:cd19172    1 YAKVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEIIDATKKGNLSRFIN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342 1224 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 1285
Cdd:cd19172   81 HSCEPNCETQKWTVNGELRVGFFAKRDIPAGEELTFDYQFERYGKEAQKCYCGSPNCRGYIG 142

SET_SETD2-like

cd10531

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...

1148-1281

1.02e-63

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.

Pssm-ID: 380929 Cd Length: 136 Bit Score: 212.50 E-value: 1.02e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1148 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCN 1227
Cdd:cd10531    3 ELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSNFYILSLSDDVVIDATRKGNLSRFINHSCE 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 74761342 1228 PNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCS 1281
Cdd:cd10531   83 PNCETQKWIVNGEYRIGIFALRDIPAGEELTFDYNFVNYNEAKQVCLCGAQNCR 136

SET_ASHR3-like

cd19175

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...

1148-1285

2.09e-55

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).

Pssm-ID: 380952 [Multi-domain] Cd Length: 139 Bit Score: 188.78 E-value: 2.09e-55

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1148 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCN 1227
Cdd:cd19175    3 KLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMCEIDKDMVIDATFKGNLSRFINHSCD 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 74761342 1228 PNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNgRTECHCGADNCSGFLG 1285
Cdd:cd19175   83 PNCELQKWQVDGETRIGVFAIRDIKKGEELTYDYQFVQFGA-DQDCHCGSKNCRGKLG 139

PWWP_NSD2_rpt1

cd20162

first PWWP domain found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; ...

268-393

7.40e-52

first PWWP domain found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2, also called histone-lysine N-methyltransferase NSD2, multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, through mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD domains mediate chromatin interaction and recognition of histone marks. This model corresponds to the first PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438990 Cd Length: 128 Bit Score: 178.18 E-value: 7.40e-52

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKIN--TRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATK 345
Cdd:cd20162    1 YNVGDLVWSKVSGYPWWPCMVSADPLLHSHTKLKgqKKSARQYHVQFFGDAPERAWIFEKSLVPFEGEGQFEQLCQESAK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 74761342  346 QASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFI 393
Cdd:cd20162   81 QAPTKAEKIKLLKPISGKLRAQWDMGIVQAEEAASMTVEERKAKFTFL 128

PWWP_NSD_rpt2

cd05838

second PWWP domain found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

959-1053

2.18e-51

second PWWP domain found in nuclear receptor-binding SET domain-containing (NSD) proteins; The nuclear receptor binding SET domain (NSD) protein family consists of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, that are critical in maintaining chromatin integrity. Reducing NSD activity through specific lysine-HMTase inhibitors appears promising in suppressing cancer growth. NSD proteins have specific mono- and dimethylase activities for H3K36, and they play nonredundant roles during development. NSD1 plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. NSD2 is involved in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. NSD3 is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD proteins contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (C5HCH). This model corresponds to the second PWWP domain. The family also includes Drosophila melanogaster maternal-effect sterile 4 (dMes4) that may act as a histone-lysine N-methyltransferase required for wing morphogenesis. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438963 [Multi-domain] Cd Length: 96 Bit Score: 175.89 E-value: 2.18e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  959 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAE-GQTSINKTF 1037
Cdd:cd05838    1 LYGDIVWVKLGNYRWWPAEILHPREVPDNIQSLPHPPGEFPVRFFGSHDYYWVHRGRVFLFEEGDKGSKEkSKKSLDKSF 80

                         90
                 ....*....|....*.
gi 74761342 1038 KKALEEAAKRFQELKA 1053
Cdd:cd05838   81 KRALKEANEAFRELKA 96

SET_ASH1L

cd19174

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...

1148-1285

4.40e-51

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).

Pssm-ID: 380951 [Multi-domain] Cd Length: 141 Bit Score: 176.71 E-value: 4.40e-51

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1148 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSvTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCN 1227
Cdd:cd19174    3 ERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNH-SHHYCLNLDSGMVIDGYRMGNEARFVNHSCD 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74761342 1228 PNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLG-NGRTECHCGADNCSGFLG 1285
Cdd:cd19174   82 PNCEMQKWSVNGVYRIGLFALKDIPAGEELTYDYNFHSFNvEKQQPCKCGSPNCRGVIG 140

PWWP_NSD_rpt1

cd20144

first PWWP domain found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

270-380

2.44e-49

first PWWP domain found in nuclear receptor-binding SET domain-containing (NSD) proteins; The nuclear receptor binding SET domain (NSD) protein family consists of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1 that are critical in maintaining the chromatin integrity. Reducing NSD activity through specific lysine-HMTase inhibitors appears promising in suppressing cancer growth. NSD proteins have specific mono- and dimethylase activities for H3K36, and play nonredundant roles during development. NSD1 plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. NSD2 is involved in cancer cell proliferation, survival, and tumor growth, through mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. NSD3 is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD proteins contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (C5HCH). This model corresponds to the first PWWP domain. This family also includes Drosophila melanogaster maternal-effect sterile 4 (dMes4) that may act as a histone-lysine N-methyltransferase required for wing morphogenesis. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438972 Cd Length: 114 Bit Score: 170.57 E-value: 2.44e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  270 VGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI---NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQ 346
Cdd:cd20144    1 VGDLVWAKVSGHPWWPCMVTYDPESGLYTKIkgsGGRTYRQYHVQFFGDNGERGWVSEKSLMPFEGKEKFEELVKELKKK 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 74761342  347 ASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALK 380
Cdd:cd20144   81 AKKKSKKAKLEKKVKPSRRKKWEIAVEEAEEALP 114

PWWP_NSD1_rpt2

cd20164

second PWWP domain found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) ...

959-1053

8.96e-49

second PWWP domain found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1, also called H3 Lysine-36 and H4 Lysine-20 specific histone-lysine N-methyltransferase, androgen receptor coactivator 267 kDa protein, androgen receptor-associated protein of 267 kDa, H3-K36-HMTase H4-K20-HMTase, Lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein, is a lysine methyltransferase that preferentially methylates H3 on Lysine36 (H3-K36) and H4 on Lysine20 (H4-K20), which is primarily associated with active transcription. It plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. It can alter transcription by interacting with the protein NSD1-interacting zinc finger protein 1 (NIZP1). It also mitigates caspase-1 activation by listeriolysin o (LLO) in macrophages, and requires functional LLO for the regulation of IL-1beta secretion. Moreover, NSD1 regulates RNA polymerase II (RNAP II) recruitment to bone morphogenetic protein 4 (BMP4). NSD1 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions. This model corresponds to the second PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438992 Cd Length: 96 Bit Score: 168.13 E-value: 8.96e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  959 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQ-TSINKTF 1037
Cdd:cd20164    1 HYKEVVWVKVGRYRWWPAEVCHPKSIPTNIQKMKHDIGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMgKGVDGTY 80

                         90
                 ....*....|....*.
gi 74761342 1038 KKALEEAAKRFQELKA 1053
Cdd:cd20164   81 KKALQEAAVRFEELKA 96

PWWP_NSD2_rpt2

cd20165

second PWWP domain found in nuclear SET domain-containing protein 2 (NSD2) and similar ...

959-1052

1.71e-47

second PWWP domain found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2, also called histone-lysine N-methyltransferase NSD2, multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, through mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, an high mobility group (HMG) box, five PHD (plant-homeodomain) zinc finger motifs, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD domains mediate chromatin interaction and recognition of histone marks. This model corresponds to the second PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438993 Cd Length: 96 Bit Score: 164.74 E-value: 1.71e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  959 HYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDK-SFAEGQTSINKTF 1037
Cdd:cd20165    1 RFQDIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRgSKYQGGKGIGKVF 80

                         90
                 ....*....|....*
gi 74761342 1038 KKALEEAAKRFQELK 1052
Cdd:cd20165   81 KNALQEAEARFREIK 95

SET

smart00317

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...

1145-1268

6.58e-42

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues

Pssm-ID: 214614 [Multi-domain] Cd Length: 124 Bit Score: 149.79 E-value: 6.58e-42

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342    1145 PDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNH 1224
Cdd:smart00317    1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 74761342    1225 SCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGN 1268
Cdd:smart00317   81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124

SET_SETD1-like

cd10518

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...

1156-1280

5.13e-37

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).

Pssm-ID: 380916 Cd Length: 150 Bit Score: 136.57 E-value: 5.13e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd10518   25 GWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGGGTYMFRIDEDLVIDATKKGNIARFINHSCDPNCYAKII 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNC 1280
Cdd:cd10518  105 TVDGEKHIVIFAKRDIAPGEELTYDYKFPIEDEEKIPCLCGAPNC 149

SET_SETMAR

cd10544

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...

1121-1284

1.31e-33

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.

Pssm-ID: 380942 [Multi-domain] Cd Length: 254 Bit Score: 130.88 E-value: 1.31e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHPQvCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRlriKRAHENSV-TNF 1199
Cdd:cd10544   67 FECNSM-CKCSESCQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEAR---RRTKSQTKgDMN 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1200 YMLTVTKDR--------IIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDV-RVGLFALCDIPAGMELTFNY--------- 1261
Cdd:cd10544  143 YIIVLREHLssgkvletFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVpKLALFAARDIVAGEELSFDYsgefsnsve 222

                        170       180
                 ....*....|....*....|....*..
gi 74761342 1262 ----NLDCLGNGRTECHCGADNCSGFL 1284
Cdd:cd10544  223 svtlARQDESKSRKPCLCGAENCRGFL 249

SET_EZH

cd10519

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...

1156-1261

2.24e-32

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.

Pssm-ID: 380917 Cd Length: 117 Bit Score: 122.35 E-value: 2.24e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTnfYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd10519   12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSS--YLFNLNDQFVVDATRKGNKIRFANHSSNPNCYAKVM 89

                         90       100
                 ....*....|....*....|....*.
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNY 1261
Cdd:cd10519   90 MVNGDHRIGIFAKRDIEAGEELFFDY 115

SET

COG2940

SET domain-containing protein (function unknown) [General function prediction only];

1142-1282

8.00e-32

SET domain-containing protein (function unknown) [General function prediction only];

Pssm-ID: 442183 [Multi-domain] Cd Length: 134 Bit Score: 121.22 E-value: 8.00e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1142 RLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRlriKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRF 1221
Cdd:COG2940    3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAE---RREPHKEPLHTYLFELDDDGVIDGALGGNPARF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74761342 1222 MNHSCNPNCEtqkWTVNGDvRVGLFALCDIPAGMELTFNYNLDClGNGRTECHCgaDNCSG 1282
Cdd:COG2940   80 INHSCDPNCE---ADEEDG-RIFIVALRDIAAGEELTYDYGLDY-DEEEYPCRC--PNCRG 133

SET_SUV39H

cd10542

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

1121-1284

3.50e-31

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.

Pssm-ID: 380940 [Multi-domain] Cd Length: 245 Bit Score: 123.56 E-value: 3.50e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHPQvCPAGDRCQNQCFTK-RLYPdAEIIKTER-RGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTN 1198
Cdd:cd10542   64 YECNSR-CKCGPDCPNRVVQRgRKVP-LCIFRTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTY 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1199 FYMLTVTKDR---IIDAGPKGNYSRFMNHSCNPNCET-QKWTVNGDV---RVGLFALCDIPAGMELTFNYNLDCLGN--- 1268
Cdd:cd10542  142 LFDLDYNDDDceyTVDAAYYGNISHFINHSCDPNLAVyAVWINHLDPrlpRIAFFAKRDIKAGEELTFDYLMTGTGGsse 221

                        170       180
                 ....*....|....*....|....
gi 74761342 1269 --------GRTECHCGADNCSGFL 1284
Cdd:cd10542  222 stipkpkdVRVPCLCGSKNCRKYL 245

C5HCH

pfam17982

NSD Cys-His rich domain; This is an NSD-specific Cys-His rich region (C5HCH) domain. Family ...

1364-1413

5.70e-30

Pssm-ID: 465605 Cd Length: 50 Bit Score: 112.95 E-value: 5.70e-30

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74761342   1364 WHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAP 1413
Cdd:pfam17982    1 WHQCSVCGSPATSFCEFCPSSFCKDHEKGALVPSALEGRLCCSEHDPESP 50

SET

pfam00856

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...

1156-1262

2.80e-29

Pssm-ID: 459965 [Multi-domain] Cd Length: 115 Bit Score: 113.39 E-value: 2.80e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342   1156 GWGLRTKRSIKKGEFVNEYVGE-LIDEEECRLRIKR---AHENSVTNFYMLTVTKD--RIID--AGPKGNYSRFMNHSCN 1227
Cdd:pfam00856    1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLyydKLELRLWGPYLFTLDEDseYCIDarALYYGNWARFINHSCD 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 74761342   1228 PNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1262
Cdd:pfam00856   81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115

PWWP_MSH6

cd05837

PWWP domain found in DNA mismatch repair protein MSH6 and similar proteins; MSH6, also called ...

268-388

6.35e-29

PWWP domain found in DNA mismatch repair protein MSH6 and similar proteins; MSH6, also called G/T mismatch-binding protein (GTBP or GTMBP), MutS protein homolog 6, or MutS-alpha 160 kDa subunit (p160), is a mismatch repair protein homologous to bacterial MutS. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, it forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Mutations in MSH6 have been linked to increased cancer susceptibility, particularly in hereditary nonpolyposis colorectal cancer in humans. MSH6 contains a PWWP domain, but its role in MSH6 remains unclear. MSH6 orthologs found in Saccharomyces cerevisiae, Caenorhabditis elegans, and Arabidopsis thaliana lack the PWWP domain. PWWP domains typically recognize DNA and histone methylated lysines.

Pssm-ID: 438962 Cd Length: 103 Bit Score: 111.99 E-value: 6.35e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGarEYHVQFFSNQPERAWVHEKRVREYKGHKQyeellAEATKQA 347
Cdd:cd05837    1 FSPGDLVWAKLEGYPWWPSLVCNHPTTGFHKKFGKKG--EVHVQFFDDPPSRAWVKAKNVKPFTGSDD-----KEFQKGG 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 74761342  348 SNHSEKQKIRKprpqreraqwdiGIAHAEKALKMTREERIE 388
Cdd:cd05837   74 MFFSKDPKWKK------------AVKEADKALKLSVEERLK 102

PHD3_NSD3

cd15655

PHD finger 3 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

798-850

8.25e-29

Pssm-ID: 277125 Cd Length: 53 Bit Score: 109.59 E-value: 8.25e-29

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74761342  798 CCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNH 850
Cdd:cd15655    1 CCTTCSMDKDIHKASKGRMMRCLRCPVAYHTGDGCVAAGSVLVTPHIIICSNH 53

PWWP

PWWP domain; The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain ...

962-1049

4.83e-28

Pssm-ID: 459964 [Multi-domain] Cd Length: 92 Bit Score: 109.05 E-value: 4.83e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342    962 QIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFA---EGQTSINKTFK 1038
Cdd:pfam00855    2 DLVWAKLKGYPWWPARVVDPEELPENVLKPKKKDGEYLVRFFGDSEFAWVKPKDLKPFDEGDEFEYlkkKKKKKKKKAFK 81

                           90
                   ....*....|.
gi 74761342   1039 KALEEAAKRFQ 1049
Cdd:pfam00855   82 KALEEAEEALK 92

SET_SETDB1

cd10517

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

1121-1284

5.76e-28

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.

Pssm-ID: 380915 [Multi-domain] Cd Length: 288 Bit Score: 115.46 E-value: 5.76e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHPQvCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNF- 1199
Cdd:cd10517  106 YECNSR-CKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQYGDEYFAELd 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1200 YMLTVTKDR------------IIDAGPKGNYSRFMNHSCNPNCETQKWTVNG-DVR---VGLFALCDIPAGMELTFNYN- 1262
Cdd:cd10517  185 YIEVVEKLKegyesdveehcyIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASRYIRAGTELTWDYNy 264

                        170       180
                 ....*....|....*....|...
gi 74761342 1263 -LDCLGNGRTECHCGADNCSGFL 1284
Cdd:cd10517  265 eVGSVPGKVLYCYCGSSNCRGRL 287

PHD5_NSD3

cd15661

PHD finger 5 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

1323-1365

6.71e-28

Pssm-ID: 277131 Cd Length: 43 Bit Score: 106.98 E-value: 6.71e-28

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 1365
Cdd:cd15661    1 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 43

SET_SETDB-like

cd10538

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...

1071-1262

9.34e-28

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380936 [Multi-domain] Cd Length: 217 Bit Score: 112.46 E-value: 9.34e-28

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1071 PPYKHIKANKVIGKVQIqVADLSEIPRCNCKPadenPCgLESECL-------------NRMLQ--------YECHPQvCP 1129
Cdd:cd10538    1 PSFTYIKDNIVGKNVQP-FSNIIDSVGCKCKD----DC-LDSKCAcaaesdgifaytkNGLLRlnnspppiFECNSK-CS 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1130 AGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTnfYMLTVTKDR- 1208
Cdd:cd10538   74 CDDDCKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGS--YLFDLDEFSd 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74761342 1209 --------IIDAGPKGNYSRFMNHSCNPNCETQK-WTVNGD---VRVGLFALCDIPAGMELTFNYN 1262
Cdd:cd10538  152 sdgdgeelCVDATFCGNVSRFINHSCDPNLFPFNvVIDHDDlryPRIALFATRDILPGEELTFDYG 217

PWWP_NSD1_rpt1

cd20161

first PWWP domain found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and ...

266-379

1.62e-27

first PWWP domain found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1, also called H3 Lysine-36 and H4 Lysine-20 specific histone-lysine N-methyltransferase, androgen receptor coactivator 267 kDa protein, androgen receptor-associated protein of 267 kDa, H3-K36-HMTase H4-K20-HMTase, Lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein, is a lysine methyltransferase that preferentially methylates H3 on Lysine36 (H3-K36) and H4 on Lysine20 (H4-K20), which is primarily associated with active transcription. It plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. It can alter transcription by interacting with the protein NSD1-interacting zinc finger protein 1 (NIZP1). It also mitigates caspase-1 activation by listeriolysin o (LLO) in macrophages, and requires functional LLO for the regulation of IL-1beta secretion. Moreover, NSD1 regulates RNA polymerase II (RNAP II) recruitment to bone morphogenetic protein 4 (BMP4). NSD1 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD domains are involved in protein-protein interactions. The model corresponds to the first PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438989 Cd Length: 116 Bit Score: 108.33 E-value: 1.62e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  266 VKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKI---NTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAE 342
Cdd:cd20161    2 VKYEVGDLVWAKFSRRPWWPCRICADPLLDTHSKMkvpSRRPCRQYYVETLGELTEKAWVAAKAVVPFEGRHQFEELPVL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 74761342  343 ATKQasnhSEKQKIRKPR-PQRERAQWDIGIAHAEKAL 379
Cdd:cd20161   82 RRRG----KQKEKDYKHKiPQKLLSLWEASVAHAEDFL 115

SET_SUV39H_DIM5-like

cd19473

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...

1110-1284

2.81e-27

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.

Pssm-ID: 380996 [Multi-domain] Cd Length: 274 Bit Score: 112.80 E-value: 2.81e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1110 LESECLN-RMLQYECHPQvCPAGDRCQNQCFTK-RLYPdAEIIKTER-RGWGLRTKRSIKKGEFVNEYVGELIDEEECRL 1186
Cdd:cd19473   70 LRGHMLNsRLPIYECHEG-CACSDDCPNRVVERgRKVP-LQIFRTSDgRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQR 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1187 RIKRAHENSVTNFYMLTVTK--------DRI------ID----AGPkgnySRFMNHSCNPNCETqkWTVNGDV------R 1242
Cdd:cd19473  148 RRDAATIAQRKDVYLFALDKfsdpdsldPRLrgdpyeIDgefmSGP----TRFINHSCDPNLRI--FARVGDHadkhihD 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74761342 1243 VGLFALCDIPAGMELTFNY-----------NLDCLGNGRTECHCGADNCSGFL 1284
Cdd:cd19473  222 LAFFAIKDIPRGTELTFDYvdgvtgldddaGDEEKEKEMTKCLCGSPKCRGYL 274

SET_KMT2C_2D

cd19171

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...

1156-1280

2.08e-25

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.

Pssm-ID: 380948 [Multi-domain] Cd Length: 153 Bit Score: 103.66 E-value: 2.08e-25

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRaHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd19171   25 GLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKI-YESQNRGIYMFRIDNDWVIDATMTGGPARYINHSCNPNCVAEVV 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNG-RTECHCGADNC 1280
Cdd:cd19171  104 TFDKEKKIIIISNRRIAKGEELTYDYKFDFEDDQhKIPCLCGAPNC 149

SET_LegAS4-like

cd10522

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...

1156-1262

1.15e-24

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.

Pssm-ID: 380920 [Multi-domain] Cd Length: 122 Bit Score: 100.49 E-value: 1.15e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSvtnfYMLTVTKD-RIIDAGPKGNYSRFMNHSCNPNCETQK 1234
Cdd:cd10522   14 GLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDPL----YPFDLNGDiLVIDAGKKGNLTRFINHSDQPNLELIV 89

                         90       100
                 ....*....|....*....|....*...
gi 74761342 1235 WTVNGDVRVGLFALCDIPAGMELTFNYN 1262
Cdd:cd10522   90 RTLKGEQHIGFVAIRDIKPGEELFISYG 117

SET_SET1

cd20072

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...

1157-1280

1.63e-24

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).

Pssm-ID: 380998 Cd Length: 148 Bit Score: 100.96 E-value: 1.63e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1157 WGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWT 1236
Cdd:cd20072   25 WGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGIGSSYLFRIDDDTVVDATKKGNIARFINHCCDPNCTAKIIK 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 74761342 1237 VNGDVRVGLFALCDIPAGMELTFNYNLDCLGNgRTECHCGADNC 1280
Cdd:cd20072  105 VEGEKRIVIYAKRDIAAGEELTYDYKFPREED-KIPCLCGAPNC 147

PHD2_NSD3

cd15652

PHD finger 2 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

751-797

2.57e-24

Pssm-ID: 277122 Cd Length: 47 Bit Score: 96.86 E-value: 2.57e-24

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 74761342  751 PCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQH 797
Cdd:cd15652    1 PCFSCKVPGKDVKRCSVNACGRFYHEACVRKYTTSAFESKGFRCPQH 47

PHD5_NSD

cd15568

PHD finger 5 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

1323-1365

3.35e-24

PHD finger 5 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, that are critical in maintaining chromatin integrity. Reducing NSD activity through specific lysine-HMTase inhibitors appears promising to help suppress cancer growth. NSD proteins have specific mono- and dimethylase activities for H3K36, and they play non-redundant roles during development. NSD1 plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. NSD2 is involved in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. NSD3 is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD proteins contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). This model corresponds to the fifth PHD finger.

Pssm-ID: 277043 [Multi-domain] Cd Length: 43 Bit Score: 96.24 E-value: 3.35e-24

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 1365
Cdd:cd15568    1 ECFRCGDGGDLVLCDFKGCPKVYHLSCLGLEKPPGGKWICPWH 43

SET_SETD1

cd19169

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...

1156-1280

5.06e-24

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.

Pssm-ID: 380946 Cd Length: 148 Bit Score: 99.33 E-value: 5.06e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd19169   24 DWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDATKCGNLARFINHSCNPNCYAKII 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNYNLDcLGNGRTECHCGADNC 1280
Cdd:cd19169  104 TVESQKKIVIYSKRPIAVNEEITYDYKFP-IEDEKIPCLCGAPQC 147

SET_SUV39H2

cd10532

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

1121-1284

9.48e-24

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.

Pssm-ID: 380930 [Multi-domain] Cd Length: 243 Bit Score: 101.89 E-value: 9.48e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHPQvCPAGDRCQNQCFTKRLYPDAEIIKTER-RGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNF 1199
Cdd:cd10532   61 YECNSR-CKCGPDCPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1200 YMLTVTKDRI-IDAGPKGNYSRFMNHSCNPNceTQKWTV---NGDV---RVGLFALCDIPAGMELTFNYNLDCLGN---- 1268
Cdd:cd10532  140 FDLDYESDEFtVDAARYGNVSHFVNHSCDPN--LQVFNVfidNLDTrlpRIALFSTRTIKAGEELTFDYQMKGSGDlssd 217

                        170       180
                 ....*....|....*....|....*.
gi 74761342 1269 ----------GRTECHCGADNCSGFL 1284
Cdd:cd10532  218 sidnspakkrVRTVCKCGAVTCRGYL 243

SET_AtSUVH-like

cd10545

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...

1121-1262

3.13e-23

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380943 [Multi-domain] Cd Length: 232 Bit Score: 100.17 E-value: 3.13e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHPQvCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKraheNSVTNFY 1200
Cdd:cd10545   63 YECGPL-CKCPPSCYNRVTQKGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSG----NDDYLFD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1201 MLTVTKDR----------------------------IIDAGPKGNYSRFMNHSCNPNCETQKWTV-NGD---VRVGLFAL 1248
Cdd:cd10545  138 IDNRQTNRgwdggqrldvgmsdgerssaedeessefTIDAGSFGNVARFINHSCSPNLFVQCVLYdHNDlrlPRVMLFAA 217

                        170
                 ....*....|....
gi 74761342 1249 CDIPAGMELTFNYN 1262
Cdd:cd10545  218 DNIPPLQELTYDYG 231

PWWP

cd05162

PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ...

962-1046

3.25e-23

PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids and is composed of a five-stranded antiparallel beta-barrel followed by a helical region. It is found in numerous proteins that are involved in cell division, growth, and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes. PWWP domains specifically recognize DNA and histone methylated lysines at the level of the nucleosome. Based on the fact that other regions of PWWP-domain proteins are responsible for nuclear localization and DNA-binding, is likely that the PWWP domain acts as a site for protein-protein binding interactions, influencing chromatin remodeling and thereby regulating transcriptional processes. Some PWWP-domain proteins have been linked to cancer or other diseases; some are known to function as growth factors.

Pssm-ID: 438958 [Multi-domain] Cd Length: 86 Bit Score: 94.87 E-value: 3.25e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  962 QIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDlGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKAL 1041
Cdd:cd05162    2 DLVWAKLKGYPWWPARVVDPEELPEEVGKKKKK-GGVLVQFFGDNDYAWVKSKNIKPFEEGFKKEFKKKKKKSKKFKKAV 80


                 ....*
gi 74761342 1042 EEAAK 1046
Cdd:cd05162   81 EEAEE 85

SET_KMT2A_2B

cd19170

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...

1156-1284

3.93e-23

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).

Pssm-ID: 380947 [Multi-domain] Cd Length: 152 Bit Score: 97.08 E-value: 3.93e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRiKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd19170   25 GRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKR-EKYYESKGIGCYMFRIDDDEVVDATMHGNAARFINHSCEPNCYSRVV 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNYNLDcLGNGRTECHCGADNCSGFL 1284
Cdd:cd19170  104 NIDGKKHIVIFALRRILRGEELTYDYKFP-IEDVKIPCTCGSKKCRKYL 151

SET_EZH2

cd19218

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...

1156-1261

4.56e-23

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.

Pssm-ID: 380995 Cd Length: 120 Bit Score: 95.75 E-value: 4.56e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKrAHENSVTNFyMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd19218   15 GWGIFIKDPVQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF-LFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVM 92

                         90       100
                 ....*....|....*....|....*.
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNY 1261
Cdd:cd19218   93 MVNGDHRIGIFAKRAIQTGEELFFDY 118

SET_SUV39H_Clr4-like

cd20073

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...

1121-1284

1.15e-22

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.

Pssm-ID: 380999 [Multi-domain] Cd Length: 259 Bit Score: 99.18 E-value: 1.15e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHpQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFY 1200
Cdd:cd20073   70 YECN-ENCDCGINCPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVTYLF 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1201 MLTVTKDRI-----IDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVR----VGLFALCDIPAGMELTFNY----NLDCLG 1267
Cdd:cd20073  149 DLDLFEDQVdeyytVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSkiydLAFFAIKDIPALEELTFDYsgrnNFDQLG 228

                        170       180       190
                 ....*....|....*....|....*....|
gi 74761342 1268 -------------NGRTECHCGADNCSGFL 1284
Cdd:cd20073  229 fignrsnskyinlKNKRPCYCGSANCRGWL 258

SET_SUV39H1

cd10525

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...

1121-1284

2.38e-22

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.

Pssm-ID: 380923 [Multi-domain] Cd Length: 255 Bit Score: 98.04 E-value: 2.38e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHPQvCPAGDRCQNQCFTKRLYPDAEIIKTER-RGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNF 1199
Cdd:cd10525   63 YECNSR-CRCGPDCPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1200 YMLTVTKD-RIIDAGPKGNYSRFMNHSCNPNceTQKWTVNGD------VRVGLFALCDIPAGMELTFNYNLDC------- 1265
Cdd:cd10525  142 FDLDYVEDvYTVDAAYYGNISHFVNHSCDPN--LQVYNVFIDnlderlPRIALFATRTIRAGEELTFDYNMQVdpvdaes 219

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 74761342 1266 ------LGNG----------RTECHCGADNCSGFL 1284
Cdd:cd10525  220 tkmdsnFGLAglpgspkkrvRIECKCGVRSCRKYL 254

PWWP_ZCWPW1

cd20145

PWWP domain found in zinc finger CW-type PWWP domain protein 1 (ZCWPW1) and similar proteins; ...

267-392

2.38e-22

PWWP domain found in zinc finger CW-type PWWP domain protein 1 (ZCWPW1) and similar proteins; ZCWPW1 is a histone H3K4me3 reader. It is associated with late-onset Alzheimer's disease (LOAD). In addition to the PWWP domain, ZCWPW1 contains a zinc finger CW (zf-CW) domain that is a histone modification reader for the histone H3 tail with trimethylated K4. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438973 Cd Length: 115 Bit Score: 93.38 E-value: 2.38e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  267 KFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAR--EYHVQFFSNQPERAWVHEKRVREYKGhkqyeellaeat 344
Cdd:cd20145    5 KYTPGSLVWAKMPGYPWWPAMVEDDPDTEEFFWLDEESDIptKYHVTFFDKPVSRAWVRASSIKPFTD------------ 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 74761342  345 kqasnHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTF 392
Cdd:cd20145   73 -----NSNEPNLTKKKGKKYKKRLNEAVEMAREALKLSIKERLKKFGF 115

SET_EZH1

cd19217

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...

1156-1261

5.15e-22

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.

Pssm-ID: 380994 Cd Length: 136 Bit Score: 93.21 E-value: 5.15e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKrAHENSVTNFyMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd19217   17 GWGTFIKESVQKNEFISEYCGELISQDEADRRGK-VYDKYMSSF-LFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVV 94

                         90       100
                 ....*....|....*....|....*.
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNY 1261
Cdd:cd19217   95 MVNGDHRIGIFAKRAIQQGEELFFDY 120

PHD1_NSD3

cd15649

PHD finger 1 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

703-746

5.53e-21

Pssm-ID: 277119 Cd Length: 44 Bit Score: 87.13 E-value: 5.53e-21

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 74761342  703 VCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECK 746
Cdd:cd15649    1 VCQVCESFGESLVTCEGECCGLFHLECLGLTSLPDEKFICQECK 44

PWWP

PWWP domain; The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain ...

271-348

8.10e-21

Pssm-ID: 459964 [Multi-domain] Cd Length: 92 Bit Score: 88.25 E-value: 8.10e-21

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74761342    271 GDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNqPERAWVHEKRVREYKGHKQYEELLAEATKQAS 348
Cdd:pfam00855    1 GDLVWAKLKGYPWWPARVVDPEELPENVLKPKKKDGEYLVRFFGD-SEFAWVKPKDLKPFDEGDEFEYLKKKKKKKKK 77

SET_SETD1B

cd19205

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...

1157-1284

2.70e-20

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.

Pssm-ID: 380982 [Multi-domain] Cd Length: 153 Bit Score: 88.96 E-value: 2.70e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1157 WGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWT 1236
Cdd:cd19205   26 WGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVIT 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 74761342 1237 VNGDVRVGLFALCDIPAGMELTFNYNLDcLGNGRTECHCGADNCSGFL 1284
Cdd:cd19205  106 VESQKKIVIYSKQHINVNEEITYDYKFP-IEDVKIPCLCGSENCRGTL 152

SET_SETD8

cd10528

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...

1148-1261

2.71e-20

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.

Pssm-ID: 380926 [Multi-domain] Cd Length: 141 Bit Score: 88.40 E-value: 2.71e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1148 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTV---TKDRIIDA-GPKGNYSRFMN 1223
Cdd:cd10528   20 KVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFqykGKTYCVDAtKESGRLGRLIN 99

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 74761342 1224 HSC-NPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNY 1261
Cdd:cd10528  100 HSKkKPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDY 138

PHD5_NSD2

cd15660

PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed ...

1323-1365

3.15e-20

PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed histone-lysine N-methyltransferase NSD2, or multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD fingers mediate chromatin interaction and recognition of histone marks. This model corresponds to the fifth PHD finger.

Pssm-ID: 277130 Cd Length: 43 Bit Score: 84.99 E-value: 3.15e-20

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 1365
Cdd:cd15660    1 ECFRCGDGGQLVLCDRKSCTKAYHLSCLGLTKRPFGKWECPWH 43

PHD4_NSD3

PHD finger 4 found in nuclear SET domain-containing protein 3 (NSD3); NSD3, also termed ...

917-952

1.60e-19

Pssm-ID: 277128 Cd Length: 40 Bit Score: 83.04 E-value: 1.60e-19

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDC 952
Cdd:cd15658    5 CARGGRLLCCESCPASFHPECLSIEMPEGCWNCNEC 40

PWWP

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

958-1019

4.68e-19

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

Pssm-ID: 214603 [Multi-domain] Cd Length: 63 Bit Score: 82.39 E-value: 4.68e-19

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74761342     958 LHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPY 1019
Cdd:smart00293    1 FKPGDLVWAKMKGFPWWPALVISPKMTPDNIMKRKSDENLYPVLFFGDKDTAWIPSSKLFPL 62

SET_SETD1A

cd19204

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...

1157-1284

8.53e-19

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.

Pssm-ID: 380981 [Multi-domain] Cd Length: 153 Bit Score: 84.69 E-value: 8.53e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1157 WGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWT 1236
Cdd:cd19204   26 WGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVIT 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 74761342 1237 VNGDVRVGLFALCDIPAGMELTFNYNLDcLGNGRTECHCGADNCSGFL 1284
Cdd:cd19204  106 IESQKKIVIYSKQPIGVNEEITYDYKFP-IEDNKIPCLCGTENCRGTL 152

SET_EHMT

cd10543

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

1119-1280

4.24e-18

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380941 [Multi-domain] Cd Length: 231 Bit Score: 85.08 E-value: 4.24e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1119 LQYECHPqVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTN 1198
Cdd:cd10543   66 LIFECNR-ACSCWRNCRNRVVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSREDDSYLFDLDN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1199 FYMLTVTkdriIDAGPKGNYSRFMNHSCNPNCETQKWTV-NGDVR---VGLFALCDIPAGMELTFNYnldclGNG----- 1269
Cdd:cd10543  145 KDGETYC----IDARRYGNISRFINHLCEPNLIPVRVFVeHQDLRfprIAFFASRDIKAGEELGFDY-----GEKfwrik 215

                        170
                 ....*....|...
gi 74761342 1270 --RTECHCGADNC 1280
Cdd:cd10543  216 gkYFTCRCGSPKC 228

SET_KMT2A

cd19206

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...

1156-1284

9.54e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).

Pssm-ID: 380983 [Multi-domain] Cd Length: 154 Bit Score: 81.61 E-value: 9.54e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELIDEEECRLRiKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd19206   25 GRGLFCKRNIDAGEMVIEYSGNVIRSILTDKR-EKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVI 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNG-RTECHCGADNCSGFL 1284
Cdd:cd19206  104 NIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASnKLPCNCGAKKCRKFL 153

SET_EZH-like

cd19168

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...

1156-1261

1.01e-17

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.

Pssm-ID: 380945 Cd Length: 124 Bit Score: 80.70 E-value: 1.01e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1156 GWGLRTKRSIKKGEFVNEYVGELI-DEEECRLRIKRaheNSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNP----NC 1230
Cdd:cd19168   13 GLGLFAAEDIKEGEFVIEYTGELIsHDEGVRREHRR---GDVSYLYLFEEQEGIWVDAAIYGNLSRYINHATDKvktgNC 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 74761342 1231 ETQKWTVNGDVRVGLFALCDIPAGMELTFNY 1261
Cdd:cd19168   90 MPKIMYVNHEWRIKFTAIKDIKIGEELFFNY 120

SET_EHMT1

cd10535

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

1119-1280

1.09e-17

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380933 [Multi-domain] Cd Length: 231 Bit Score: 83.83 E-value: 1.09e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1119 LQYECHpQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTN 1198
Cdd:cd10535   66 LIFECN-HACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1199 fymltvtKDR---IIDAGPKGNYSRFMNHSCNPN-CETQKWTVNGDV---RVGLFALCDIPAGMELTFNYN---LDCLGN 1268
Cdd:cd10535  145 -------KDGevyCIDARFYGNVSRFINHHCEPNlVPVRVFMAHQDLrfpRIAFFSTRLIEAGEQLGFDYGerfWDIKGK 217

                        170
                 ....*....|..
gi 74761342 1269 GRTeCHCGADNC 1280
Cdd:cd10535  218 LFS-CRCGSPKC 228

SET_SETDB2

cd10523

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...

1104-1284

3.46e-17

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.

Pssm-ID: 380921 [Multi-domain] Cd Length: 266 Bit Score: 83.34 E-value: 3.46e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1104 DENPCGLESECLNRMLQ---YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELI- 1179
Cdd:cd10523   64 SKGGRGYKYKRLQEPIPsglYECNVSCKCNRMLCQNRVVQHGLQVRLQVFKTEKKGWGVRCLDDIDKGTFVCIYAGRVLs 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1180 ---DEEE---CRLRIKRAHENSVTNFYMLTVTKDR------IIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVR----V 1243
Cdd:cd10523  144 rarSPTEplpPKLELPSENEVEVVTSWLILSKKRKlrenvcFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKnfpwV 223

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1244 GLFALCDIPAGMELTFNYNLDCLGNGRTE--CHCGADNCSGFL 1284
Cdd:cd10523  224 AFFTNRVVKAGTELTWDYSYDAGTSPEQEipCLCGVNKCQKKI 266

SET_EHMT2

cd10533

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...

1119-1280

8.85e-17

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.

Pssm-ID: 380931 [Multi-domain] Cd Length: 239 Bit Score: 81.60 E-value: 8.85e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1119 LQYECHpQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTN 1198
Cdd:cd10533   66 LIFECN-QACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1199 fymltvtKD---RIIDAGPKGNYSRFMNHSCNPN-CETQKWTVNGDV---RVGLFALCDIPAGMELTFNYNlDCLGNGRT 1271
Cdd:cd10533  145 -------KDgevYCIDARYYGNISRFINHLCDPNiIPVRVFMLHQDLrfpRIAFFSSRDIRTGEELGFDYG-DRFWDIKS 216

                        170
                 ....*....|..
gi 74761342 1272 E---CHCGADNC 1280
Cdd:cd10533  217 KyftCQCGSEKC 228

SET

cd08161

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...

1150-1262

1.03e-16

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.

Pssm-ID: 380914 [Multi-domain] Cd Length: 72 Bit Score: 75.75 E-value: 1.03e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1150 IKTERRGWGLRTKRSIKKGEFvneyvgelideeecrlrikrahensvtnfymltvtkdrIIDAgpkgnysRFMNHSCNPN 1229
Cdd:cd08161    5 STIPGAGFGLFATRDIPKGEV--------------------------------------IGLA-------RFINHSCEPN 39

                         90       100       110
                 ....*....|....*....|....*....|...
gi 74761342 1230 CETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1262
Cdd:cd08161   40 CEFEEVYVGGKPRVFIVALRDIKAGEELTVDYG 72

PHD5_NSD1

cd15659

PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, ...

1324-1365

1.60e-16

PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, also termed H3 Lysine-36 and H4 Lysine-20 specific histone-lysine N-methyltransferase, or androgen receptor coactivator 267 kDa protein, or androgen receptor-associated protein of 267 kDa, or H3-K36-HMTase H4-K20-HMTase, or Lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein, is a lysine methyltransferase that preferentially methylates H3 on Lysine36 (H3-K36) and H4 on Lysine20 (H4-K20), which is primarily associated with active transcription. It plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma and glioblastoma formation. It can alter transcription by interacting with the protein NSD1-interacting zinc finger protein 1 (NIZP1). It also mitigates caspase-1 activation by listeriolysin o (LLO) in macrophages, and requires functional LLO for the regulation of IL-1beta secretion. Moreover, NSD1 regulates RNA polymerase II (RNAP II) recruitment to bone morphogenetic protein 4 (BMP4). NSD1 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the fifth PHD finger.

Pssm-ID: 277129 Cd Length: 43 Bit Score: 74.59 E-value: 1.60e-16

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 74761342 1324 CFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWH 1365
Cdd:cd15659    2 CFSCGDGGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWH 43

PHD2_NSD2

cd15651

PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed ...

752-797

3.03e-16

PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed histone-lysine N-methyltransferase NSD2, or multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant homeodomain) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD fingers mediate chromatin interaction and recognition of histone marks. This model corresponds to the second PHD finger.

Pssm-ID: 277121 Cd Length: 47 Bit Score: 73.72 E-value: 3.03e-16

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 74761342  752 CFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQH 797
Cdd:cd15651    2 CFVCKESKGDVKRCVVLHCGKFYHEACVRKYPLTVFENRGFRCPLH 47

SET_SETDB

cd10541

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...

1121-1284

3.91e-16

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.

Pssm-ID: 380939 [Multi-domain] Cd Length: 236 Bit Score: 79.51 E-value: 3.91e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1121 YECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRlriKRAHENSVTNFY 1200
Cdd:cd10541   68 YECNKLCKCDPNMCQNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFAD---KEGLEMGDEYFA 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1201 MLTVTKDR--IIDAGPKGNYSRFMNHSCNPNCETQKWTVNG-DVR---VGLFALCDIPAGMELTFNYNLDClgnGRTE-- 1272
Cdd:cd10541  145 NLDHIEEScyIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThDLRfpwVAFFASKRIKAGTELTWDYNYEV---GSVEgk 221

                        170
                 ....*....|....*
gi 74761342 1273 ---CHCGADNCSGFL 1284
Cdd:cd10541  222 ellCCCGSNECRGRL 236

SET_KMT2D

cd19209

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...

1149-1284

4.26e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.

Pssm-ID: 380986 [Multi-domain] Cd Length: 155 Bit Score: 77.04 E-value: 4.26e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1149 IIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRiKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNP 1228
Cdd:cd19209   20 LARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRR-EKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAP 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 74761342 1229 NCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNG-RTECHCGADNCSGFL 1284
Cdd:cd19209   99 NCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQhKIPCHCGAWNCRKWM 155

PWWP_AtATX3-like

cd20143

PWWP domain found in Arabidopsis thaliana histone-lysine N-methyltransferase trithorax-like ...

962-1044

4.32e-16

PWWP domain found in Arabidopsis thaliana histone-lysine N-methyltransferase trithorax-like protein ATX3, ATX4, ATX5, and similar proteins; The family includes A. thaliana ATX3 (also called protein SET domain group 14, or trithorax-homolog protein 3), ATX4 (also called protein SET domain group 16, or trithorax-homolog protein 4) and ATX5 (also called protein SET domain group 29, or trithorax-homolog protein 5), which belong to the histone-lysine methyltransferase family. They show distinct phylogenetic origins from the family of ATX1 and ATX2. They are multi-domain containing protein that consists of an N-terminal PWWP domain, a canonical plant homeodomain (PHD) domain, a non-canonical extended PHD (ePHD) domain, and a C-terminal SET domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438971 [Multi-domain] Cd Length: 100 Bit Score: 75.10 E-value: 4.32e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  962 QIVWVKLGNYRWWPAEICNPRSVPLNIQgLKHDLGDFPVFFFG---SHDYYWVHQGRVFPYVEGDKSFAEGQTSINKT-- 1036
Cdd:cd20143    4 DLVWAKVGTHPFWPARVVEPAEQAEEVR-RRCVPGSLCVYFFGpggSRDYGWVRRSMIFPFTDDLARFQTQKIKNKKRpq 82


                 ....*....
gi 74761342 1037 -FKKALEEA 1044
Cdd:cd20143   83 eFQEALEEA 91

PHD1_NSD

cd15564

PHD finger 1 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

703-746

4.78e-16

PHD finger 1 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, that are critical in maintaining chromatin integrity. Reducing NSD activity through specific lysine-HMTase inhibitors appears promising to help suppress cancer growth. NSD proteins have specific mono- and dimethylase activities for H3K36, and they non-redundant roles during development. NSD1 plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. NSD2 is involved in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. NSD3 is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD proteins contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). This model corresponds to the first PHD finger.

Pssm-ID: 277039 Cd Length: 43 Bit Score: 73.14 E-value: 4.78e-16

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 74761342  703 VCQICESSGDsLIPCEGECCKHFHLECLGLASLPDSKFICMECK 746
Cdd:cd15564    1 VCQICEKPGK-LLTCEGPCCGHFHLDCLGLSEQPDEPFKCDECT 43

PHD3_NSD2

cd15654

PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed ...

810-850

8.41e-16

PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed histone-lysine N-methyltransferase NSD2, or multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant homeodomain) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD fingers mediate chromatin interaction and recognition of histone marks. This model corresponds to the third PHD finger.

Pssm-ID: 277124 Cd Length: 54 Bit Score: 72.57 E-value: 8.41e-16

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 74761342  810 KASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNH 850
Cdd:cd15654   14 RATKGKMMRCVRCPVAYHGGDLCIAAGCAVLTSNSIICTNH 54

SET_KMT2C

cd19208

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...

1155-1284

1.02e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.

Pssm-ID: 380985 [Multi-domain] Cd Length: 154 Bit Score: 75.82 E-value: 1.02e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1155 RGWGLRTKRSIKKGEFVNEYVGELIDEEECRlRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQK 1234
Cdd:cd19208   25 QGLGLYAARDIEKHTMVIEYIGTIIRNEVAN-RKEKLYESQNRGVYMFRIDNDHVIDATLTGGPARYINHSCAPNCVAEV 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74761342 1235 WTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNG-RTECHCGADNCSGFL 1284
Cdd:cd19208  104 VTFEKGHKIIISSSRRIQKGEELCYDYKFDFEDDQhKIPCHCGAVNCRKWM 154

SET_KMT2B

cd19207

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...

1149-1284

7.74e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.

Pssm-ID: 380984 [Multi-domain] Cd Length: 154 Bit Score: 73.52 E-value: 7.74e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1149 IIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRiKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNP 1228
Cdd:cd19207   18 VYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKR-EKFYDSKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEP 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 74761342 1229 NCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCL-GNGRTECHCGADNCSGFL 1284
Cdd:cd19207   97 NCYSRVIHVEGQKHIVIFALRKIYRGEELTYDYKFPIEdASNKLPCNCGAKRCRRFL 153

PHD4_NSD2

cd15657

PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed ...

917-953

1.30e-14

PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2); NSD2, also termed histone-lysine N-methyltransferase NSD2, or multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). NSD2 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-prolin motif (PWWP) domains, a high mobility group (HMG) box, five PHD (plant-homeodomain) zinc fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD fingers mediate chromatin interaction and recognition of histone marks. This model corresponds to the fourth PHD finger.

Pssm-ID: 277127 Cd Length: 41 Bit Score: 68.88 E-value: 1.30e-14

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCK 953
Cdd:cd15657    5 CSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCR 41

PHD2_NSD

cd15565

PHD finger 2 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

752-797

2.64e-14

PHD finger 2 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, that are critical in maintaining chromatin integrity. Reducing NSD activity through specific lysine-HMTase inhibitors appears promising to help suppress cancer growth. NSD proteins have specific mono- and dimethylase activities for H3K36, and they play non-redundant roles during development. NSD1 plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. NSD2 is involved in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. NSD3 is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD proteins contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). This model corresponds to the second PHD finger.

Pssm-ID: 277040 Cd Length: 51 Bit Score: 68.22 E-value: 2.64e-14

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 74761342  752 CFSCKVSGK---DVKRCSVGACGKFYHEACVRKFP-TAIFESKGFRCPQH 797
Cdd:cd15565    2 CFVCKKLGSvggEVFKCSVASCGKFYHEECLKKWPlTTISDSKKFRCPLH 51

PWWP

cd05162

PWWP (Pro-Trp-Trp-Pro) domain; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, ...

271-378

5.75e-14

Pssm-ID: 438958 [Multi-domain] Cd Length: 86 Bit Score: 68.68 E-value: 5.75e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  271 GDLVWSKVGTYPWWPCMVSSDPQLEVHTKiNTRGAREYHVQFFSNQpERAWVHEKRVREYkghkqyeellaeatkqasnh 350
Cdd:cd05162    1 GDLVWAKLKGYPWWPARVVDPEELPEEVG-KKKKKGGVLVQFFGDN-DYAWVKSKNIKPF-------------------- 58

                         90       100
                 ....*....|....*....|....*...
gi 74761342  351 SEKQKIRKPRPQRERAQWDIGIAHAEKA 378
Cdd:cd05162   59 EEGFKKEFKKKKKKSKKFKKAVEEAEEA 86

AWS

pfam17907

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc ...

1104-1142

6.32e-14

Pssm-ID: 465559 Cd Length: 39 Bit Score: 67.07 E-value: 6.32e-14

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 74761342   1104 DENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKR 1142
Cdd:pfam17907    1 DDPPCGCGSDCINRMLFVECTPKTCPCGESCQNQRFQRK 39

PHD4_NSD

cd15567

PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

917-952

7.85e-14

PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, that are critical in maintaining chromatin integrity. Reducing NSD activity through specific lysine-HMTase inhibitors appears promising to help suppress cancer growth. NSD proteins have specific mono- and dimethylase activities for H3K36, and they play non-redundant roles during development. NSD1 plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. NSD2 is involved in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. NSD3 is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to development of acute myeloid leukemia. NSD proteins contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). This model corresponds to the fourth PHD finger.

Pssm-ID: 277042 [Multi-domain] Cd Length: 41 Bit Score: 66.89 E-value: 7.85e-14

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIE-MPEGCWNCNDC 952
Cdd:cd15567    5 CSEGGSLICCESCPASFHPECLGLEpPPEGKFYCEDC 41

PHD2_NSD1

cd15650

PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, ...

752-797

1.20e-13

PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, also termed H3 Lysine-36 and H4 Lysine-20 specific histone-lysine N-methyltransferase, or androgen receptor coactivator 267 kDa protein, or androgen receptor-associated protein of 267 kDa, or H3-K36-HMTase H4-K20-HMTase, or LysineN-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein, is a lysine methyltransferase that preferentially methylates H3 on Lysine36 (H3-K36) and H4 on Lysine20 (H4-K20), which is primarily associated with active transcription. It plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. It can alter transcription by interacting with the protein NSD1-interacting zinc finger protein 1 (NIZP1). It also mitigates caspase-1 activation by listeriolysin o (LLO) in macrophages, and requires functional LLO for the regulation of IL-1beta secretion. Moreover, NSD1 regulates RNA polymerase II (RNAP II) recruitment to bone morphogenetic protein 4 (BMP4). NSD1 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (C5HCH). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the second PHD finger.

Pssm-ID: 277120 Cd Length: 47 Bit Score: 66.45 E-value: 1.20e-13

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 74761342  752 CFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQH 797
Cdd:cd15650    2 CFVCKKSDEDVRRCMLPLCGKFYHEECVLKYPPTVMQNRGFRCSLH 47

SET_SETD5-like

cd10529

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...

1158-1265

1.65e-13

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.

Pssm-ID: 380927 Cd Length: 127 Bit Score: 68.84 E-value: 1.65e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1158 GLRTKRSIKKGEFVNEYVGELIDEEECRlrikraHENSVTN-------FYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNC 1230
Cdd:cd10529   18 GLVATEDISPGEPILEYKGEVSLRSEFK------EDNGFFKrpspfvfFYDGFEGLPLCVDARKYGNEARFIRRSCRPNA 91

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 74761342 1231 ETQKWTV-NGDVRVGLFALCDIPAGMELTFNYNLDC 1265
Cdd:cd10529   92 ELRHVVVsNGELRLFIFALKDIRKGTEITIPFDYDY 127

PHD3_NSD1

cd15653

PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, ...

811-850

4.32e-13

PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, also termed H3 Lysine-36 and H4 Lysine-20 specific histone-lysine N-methyltransferase, or androgen receptor coactivator 267 kDa protein, or androgen receptor-associated protein of 267 kDa, or H3-K36-HMTase H4-K20-HMTase, or Lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein, is a lysine methyltransferase that preferentially methylates H3 on Lysine36 (H3-K36) and H4 on Lysine20 (H4-K20), which is primarily associated with active transcription. It plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. It can alter transcription by interacting with the protein NSD1-interacting zinc finger protein 1 (NIZP1). It also mitigates caspase-1 activation by listeriolysin o (LLO) in macrophages, and requires functional LLO for the regulation of IL-1beta secretion. Moreover, NSD1 regulates RNA polymerase II (RNAP II) recruitment to bone morphogenetic protein 4 (BMP4). NSD1 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the third PHD finger.

Pssm-ID: 277123 Cd Length: 54 Bit Score: 64.94 E-value: 4.32e-13

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 74761342  811 ASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNH 850
Cdd:cd15653   15 ASKGRLMRCVRCPVAYHANDFCLAAGSVILASNSIICPNH 54

PHD3_NSD

cd15566

PHD finger 3 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

798-850

1.74e-12

PHD finger 3 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, that are critical in maintaining chromatin integrity. Reducing NSD activity through specific lysine-HMTase inhibitors appears promising to help suppress cancer growth. NSD proteins have specific mono- and dimethylase activities for H3K36, and they play non-redundant roles during development. NSD1 plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. NSD2 is involved in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. NSD3 is amplified in human breast cancer cell lines. Moreover, translocation resulting in NUP98 fusion to NSD3 leads to the development of acute myeloid leukemia. NSD proteins contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). This model corresponds to the third PHD finger.

Pssm-ID: 277041 Cd Length: 48 Bit Score: 63.22 E-value: 1.74e-12

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74761342  798 CCSACSMEKDihkASKGRMMRCLRCPVAYHSGdaCIAAGSMLVSSYILICSNH 850
Cdd:cd15566    1 TCATCEASGD---GSSGKLVRCIRCPRAYHAG--CIPAGSKLLNKKLIICPKH 48

PHD4_NSD1

cd15656

PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, ...

917-952

2.47e-12

PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, also termed H3 Lysine-36 and H4 Lysine-20 specific histone-lysine N-methyltransferase, or androgen receptor coactivator 267 kDa protein, or androgen receptor-associated protein of 267 kDa, or H3-K36-HMTase H4-K20-HMTase, or Lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein, is a lysine methyltransferase that preferentially methylates H3 on Lysine36 (H3-K36) and H4 on Lysine20 (H4-K20), which is primarily associated with active transcription. It plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. It can alter transcription by interacting with the protein NSD1-interacting zinc finger protein 1 (NIZP1). It also mitigates caspase-1 activation by listeriolysin o (LLO) in macrophages, and requires functional LLO for the regulation of IL-1beta secretion. Moreover, NSD1 regulates RNA polymerase II (RNAP II) recruitment to bone morphogenetic protein 4 (BMP4). NSD1 contains a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). The SET domain is responsible for histone methyltransferase activity. The PWWP and PHD fingers are involved in protein-protein interactions. This model corresponds to the fourth PHD finger.

Pssm-ID: 277126 Cd Length: 40 Bit Score: 62.34 E-value: 2.47e-12

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDC 952
Cdd:cd15656    5 CSEGGSLLCCESCPAAFHRECLNIDMPEGSWYCNDC 40

PWWP

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

268-330

2.50e-12

domain with conserved PWWP motif; conservation of Pro-Trp-Trp-Pro residues

Pssm-ID: 214603 [Multi-domain] Cd Length: 63 Bit Score: 63.13 E-value: 2.50e-12

                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74761342     268 FQVGDLVWSKVGTYPWWPCMVssDPQLEVHTKINTRGARE--YHVQFFSNqPERAWVHEKRVREY 330
Cdd:smart00293    1 FKPGDLVWAKMKGFPWWPALV--ISPKMTPDNIMKRKSDEnlYPVLFFGD-KDTAWIPSSKLFPL 62

PWWP_ZCWPW2

cd20146

PWWP domain found in zinc finger CW-type PWWP domain protein 2 (ZCWPW2) and similar proteins; ...

267-388

5.05e-12

PWWP domain found in zinc finger CW-type PWWP domain protein 2 (ZCWPW2) and similar proteins; ZCWPW2 is a histone H3K4me3 reader. In addition to the PWWP domain, ZCWPW2 contains a zinc finger CW (zf-CW) domain that is a histone modification reader for the histone H3 tail with trimethylated K4. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438974 Cd Length: 113 Bit Score: 63.85 E-value: 5.05e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  267 KFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGARE-YHVQFFSNQPERAWVHEKRVREYKghkqyeellaeatk 345
Cdd:cd20146    8 QLPLGSLVWAKMTGYPRWPAILTPDPICGEYVDYDEDGEVEkYHVEFLGKPHSHAWISAKSVEPYN-------------- 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 74761342  346 qasnhsEKQKIRKPRPQR--ERAQW-DIGIAHAEKALKMTREERIE 388
Cdd:cd20146   74 ------SNTKTPKCKTKKskKRKKSyESALEEAERLLKLTCEERLE 113

PHD1_NSD1_2

cd15648

PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2; ...

703-746

1.06e-11

PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2; NSD1, also termed H3 Lysine-36 and H4 Lysine-20 specific histone-lysine N-methyltransferase, or androgen receptor coactivator 267 kDa protein, or androgen receptor-associated protein of 267 kDa, or H3-K36-HMTase H4-K20-HMTase, or Lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein, is a lysine methyltransferase that preferentially methylates H3 on Lysine36 (H3-K36) and H4 on Lysine20 (H4-K20), which is primarily associated with active transcription. It plays a role in several pathologies, including but not limited to Sotos and Weaver syndromes, acute myeloid leukemia, breast cancer, neuroblastoma, and glioblastoma formation. It can alter transcription by interacting with the protein NSD1-interacting zinc finger protein 1 (NIZP1). It also mitigates caspase-1 activation by listeriolysin o (LLO) in macrophages, and requires functional LLO for the regulation of IL-1beta secretion. Moreover, NSD1 regulates RNA polymerase II (RNAP II) recruitment to bone morphogenetic protein 4 (BMP4). NSD2, also termed histone-lysine N-methyltransferase NSD2, or multiple myeloma SET domain-containing protein (MMSET), or protein trithorax-5 Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), is overexpressed frequently in the t(4;14) translocation in 15% to 20% of multiple myeloma. It plays important roles in cancer cell proliferation, survival, and tumor growth, by mediating constitutive NF-kappaB signaling via the cytokine autocrine loop. It also enhances androgen receptor (AR)-mediated transcription. The principal chromatin-regulatory activity of NSD2 is dimethylation of histone H3 at lysine 36 (H3K36me2). Both NSD1 and NSD2 contain a catalytic suppressor of variegation, enhancer of zeste and trithorax (SET) domain, two proline-tryptophan-tryptophan-proline (PWWP) domains, five plant homeodomain (PHD) fingers, and an NSD-specific Cys-His rich domain (Cys5HisCysHis). In addition, NSD2 harbors a high mobility group (HMG) box. The SET domain is responsible for histone methyltransferase activity. The PWWP, HMG, and PHD fingers mediate chromatin interaction and recognition of histone marks. This model corresponds to the first PHD finger.

Pssm-ID: 277118 Cd Length: 43 Bit Score: 60.95 E-value: 1.06e-11

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 74761342  703 VCQICESSGDSLIpCEGECCKHFHLECLGLASLPDSKFICMECK 746
Cdd:cd15648    1 VCQVCEKPGELLL-CEGQCCGAFHLDCIGLSEMPSGKFICDECI 43

PWWP_GLYR1

cd05836

PWWP domain found in glyoxylate reductase 1 (GLYR1) and similar proteins; GLYR1, also called ...

963-1046

2.33e-11

PWWP domain found in glyoxylate reductase 1 (GLYR1) and similar proteins; GLYR1, also called 3-hydroxyisobutyrate dehydrogenase-like protein, cytokine-like nuclear factor N-PAC, nuclear protein NP60, or nuclear protein of 60 kDa, is a putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. It recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). GLYR1 enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In addition to the PWWP domain, GLYR1 also contains an AT-hook and a C-terminal NAD-binding domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438961 [Multi-domain] Cd Length: 86 Bit Score: 61.08 E-value: 2.33e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPAEICNPrsvPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFaeGQTSINKTFKKALE 1042
Cdd:cd05836    6 LVWAKMKGFPPWPGKIVNP---PPDLKKPPRKKKMHCVYFFGSENYAWIEDENIKPYEEFKEEM--LKSKKSAGFKDAVE 80


                 ....
gi 74761342 1043 EAAK 1046
Cdd:cd05836   81 AIEE 84

SET_Suv4-20-like

cd10524

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...

1154-1275

4.76e-11

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.

Pssm-ID: 380922 [Multi-domain] Cd Length: 141 Bit Score: 61.91 E-value: 4.76e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1154 RRGWGLRTKRSIKKGEFVNEYVG---ELIDEEECRLRikrAHENSVTNFYMLTVTKDRIIDaGPkgnySRFMNHSCNPNC 1230
Cdd:cd10524   17 HYGAKIIATKPIKKGEKIHELCGciaELSEEEEALLR---PGGNDFSVMYSSRKKCSQLWL-GP----AAFINHDCRPNC 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 74761342 1231 etqKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHC 1275
Cdd:cd10524   89 ---KFVPTGKSTACVKVLRDIEPGEEITVYYGDNYFGENNEECEC 130

AWS

smart00570

associated with SET domains; subdomain of PRESET

1094-1144

3.02e-10

associated with SET domains; subdomain of PRESET

Pssm-ID: 197795 Cd Length: 50 Bit Score: 57.02 E-value: 3.02e-10

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 74761342    1094 EIPRCNCKP--ADENPCGleSECLNRMLQYEChPQVCPAGDRCQNQCFTKRLY 1144
Cdd:smart00570    1 DIMTCECKPtdDDETACG--SDCLNRMLFIEC-SSSCPCGSYCSNQRFQKRQY 50

PHD2_CHD_II

cd15532

PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins; Class II CHD ...

1323-1363

8.36e-10

PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins; Class II CHD proteins includes chromodomain-helicase-DNA-binding protein CHD3, CHD4, and CHD5, which are nuclear and ubiquitously expressed chromatin remodelling ATPases generally associated with histone deacetylases (HDACs). They are involved in DNA Double Strand Break (DSB) signaling, DSB repair and/or p53-dependent pathways such as apoptosis and senescence, as well as in the maintenance of genomic stability, and/or cancer prevention. They function as subunits of the Nucleosome Remodelling and Deacetylase (NuRD) complex, which is generally associated with gene repression, heterochromatin formation, and overall chromatin compaction. In contrast to the class I CHD enzymes (CHD1 and CHD2), class II CHD proteins lack identifiable DNA-binding domains, but possess a C-terminal coiled-coil region. Moreover, in addition to the tandem chromodomains and a helicase domain, they all harbor tandem plant homeodomain (PHD) zinc fingers involved in the recognition of methylated histone tails. This model corresponds to the second PHD finger.

Pssm-ID: 277007 [Multi-domain] Cd Length: 43 Bit Score: 55.36 E-value: 8.36e-10

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLN--LTQPPYGKWECP 1363
Cdd:cd15532    1 FCRVCKDGGELLCCDG--CPSSYHLHCLNppLAEIPDGDWFCP 41

PHD1_CHD_II

cd15531

PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins; Class II CHD ...

1323-1363

2.58e-09

PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins; Class II CHD proteins includes chromodomain-helicase-DNA-binding protein CHD3, CHD4, and CHD5, which are nuclear and ubiquitously expressed chromatin remodelling ATPases generally associated with histone deacetylases (HDACs). They are involved in DNA Double Strand Break (DSB) signaling, DSB repair and/or p53-dependent pathways such as apoptosis and senescence, as well as in the maintenance of genomic stability, and/or cancer prevention. They function as subunits of the Nucleosome Remodelling and Deacetylase (NuRD) complex, which is generally associated with gene repression, heterochromatin formation, and overall chromatin compaction. In contrast to the class I CHD enzymes (CHD1 and CHD2), class II CHD proteins lack identifiable DNA-binding domains, but possess a C-terminal coiled-coil region. Moreover, in addition to the tandem chromodomains and a helicase domain, they all harbor tandem plant homeodomain (PHD) zinc fingers involved in the recognition of methylated histone tails. This model corresponds to the first PHD finger.

Pssm-ID: 277006 [Multi-domain] Cd Length: 43 Bit Score: 54.15 E-value: 2.58e-09

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLN--LTQPPYGKWECP 1363
Cdd:cd15531    1 YCEVCQQGGEIILCDT--CPRAYHLVCLDpeLEKAPEGKWSCP 41

PHD1_AIRE

cd15539

PHD finger 1 found in autoimmune regulator (AIRE); AIRE, also termed autoimmune ...

917-952

1.88e-08

PHD finger 1 found in autoimmune regulator (AIRE); AIRE, also termed autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) protein, functions as a regulator of gene transcription in the thymus. It is essential for prevention of autoimmunity. AIRE plays a critical role in the induction of central tolerance. It promotes self-tolerance through tissue-specific antigen (TSA) expression. It also acts as an active regulator of chondrocyte differentiation. AIRE contains a homogeneously-staining region (HSR) or caspase-recruitment domain (CARD), a nuclear localization signal (NLS), a SAND (for Sp100, AIRE, nuclear phosphoprotein 41/75 or NucP41/75, and deformed epidermal auto regulatory factor 1 or Deaf1) domain, two plant homeodomain (PHD) fingers, and four LXXLL (where L stands for leucine) motifs. This model corresponds to the first PHD finger that recognizes the unmethylated tail of histone H3 and targets AIRE-dependent genes.

Pssm-ID: 277014 [Multi-domain] Cd Length: 43 Bit Score: 51.68 E-value: 1.88e-08

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSI---EMPEGCWNCNDC 952
Cdd:cd15539    5 CGDGGELLCCDGCPRAFHLACLVPpltLIPSGTWRCSSC 43

PHD2_CHD_II

cd15532

PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins; Class II CHD ...

915-952

2.09e-08

Pssm-ID: 277007 [Multi-domain] Cd Length: 43 Bit Score: 51.51 E-value: 2.09e-08

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 74761342  915 KKCEKGGRLLCCESCPASFHPECLS---IEMPEGCWNCNDC 952
Cdd:cd15532    3 RVCKDGGELLCCDGCPSSYHLHCLNpplAEIPDGDWFCPRC 43

PHD1_AIRE

cd15539

PHD finger 1 found in autoimmune regulator (AIRE); AIRE, also termed autoimmune ...

1323-1370

2.24e-08

Pssm-ID: 277014 [Multi-domain] Cd Length: 43 Bit Score: 51.30 E-value: 2.24e-08

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 74761342 1323 YCFQCGDGGELVMCDkkDCPKAYHLLCLN--LTQPPYGKWecpwhQCDEC 1370
Cdd:cd15539    1 ECAVCGDGGELLCCD--GCPRAFHLACLVppLTLIPSGTW-----RCSSC 43

PWWP_DNMT3

cd05835

PWWP domain found in the DNA (cytosine-5)-methyltransferase 3 (DNMT3) family; The DNMT3 family ...

962-1047

3.26e-08

PWWP domain found in the DNA (cytosine-5)-methyltransferase 3 (DNMT3) family; The DNMT3 family includes DNMT3A and DNMT3B, which are required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNMT3A, also called DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, or M.HsaIIIA, modifies DNA in a non-processive manner and also methylates non-CpG sites. It may preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. DNMT3A is recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. DNMT3B, also called DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, or M.HsaIIIB, may preferentially methylate nucleosomal DNA within the nucleosome core region. DNMT3B may function as a transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Members of this family contains a PWWP domain that is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by DNMT3B is known to play a role in the inactivation of tumor suppressor genes. In addition, a point mutation in the PWWP domain of DNMT3B has been identified in patients with ICF (immunodeficiency, centromeric instability, and facial anomalie) syndrome , a rare autosomal recessive disorder characterized by hypomethylation of classical satellite DNA.

Pssm-ID: 438960 [Multi-domain] Cd Length: 89 Bit Score: 52.26 E-value: 3.26e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  962 QIVWVKLGNYRWWPAEICNPRsvplNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSiNKTFKK-- 1039
Cdd:cd05835    4 DLVWAKLKGSPWWPGIVVSHK----DCGQKPPAEGSVWVFWFGDHKVSEVPLDKILPFAEFFNKFYISKNS-SKLYKKav 78

                         90
                 ....*....|
gi 74761342 1040 --ALEEAAKR 1047
Cdd:cd05835   79 yeALKEAAER 88

PWWP_HRP

cd05834

PWWP domain found in hepatoma-derived growth factor (HDGF)-related protein (HRP) family; The ...

963-1043

3.34e-08

PWWP domain found in hepatoma-derived growth factor (HDGF)-related protein (HRP) family; The HRP family includes hepatoma-derived growth factor (HDGF), and HDGF-related proteins (HRPs). HDGF, also called high mobility group protein 1-like 2 (HMG-1L2), is a heparin-binding protein that acts as a transcriptional repressor with mitogenic activity for fibroblasts. It is a prognostic factor in several types of cancer. HDGFL1 is also called PWWP domain-containing protein 1 (PWWP1). Its biological function remains unclear. HDGFL2, also called HDGF-related protein 2 (HRP-2), or hepatoma-derived growth factor 2 (HDGF-2), is involved in cellular growth control, through the regulation of cyclin D1 expression. HDGFL3, also called HDGF-related protein 3 (HRP-3), enhances DNA synthesis and may play a role in cell proliferation. The family also includes PC4 and SFRS1-interacting protein (PSIP) and similar proteins. PSIP, also called CLL-associated antigen KW-7, dense fine speckles 70 kDa protein (DFS 70), lens epithelium-derived growth factor (LEDGF), or transcriptional coactivator p75/p52, acts as a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Members of the HRP family contains a PWWP domain, which is necessary for DNA binding.

Pssm-ID: 438959 [Multi-domain] Cd Length: 82 Bit Score: 52.17 E-value: 3.34e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPAEICNprsVPLNIQGLKhdlGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFaeGQTSINKTFKKALE 1042
Cdd:cd05834    6 LVFAKVKGYPPWPARIDE---IPEGAKIPK---NKYPVFFYGTHETAFLKPKDLFPYEENKEKY--GKPRKRKGFNEGLW 77


                 .
gi 74761342 1043 E 1043
Cdd:cd05834   78 E 78

SET_SMYD

cd20071

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...

1148-1261

3.87e-08

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.

Pssm-ID: 380997 [Multi-domain] Cd Length: 122 Bit Score: 53.15 E-value: 3.87e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1148 EIIKTER-RGWGLRTKRSIKKGEfvneyvgELIDEEEcrlrIKRAHENSVTNFymltvTKDRIIDAG--PKGNysrFMNH 1224
Cdd:cd20071    1 EVRESEGsKGRGLVATRDIEPGE-------LILVEKP----LVSVPSNSFSLT-----DGLNEIGVGlfPLAS---LLNH 61

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 74761342 1225 SCNPNCEtqkWTVNGDVRVGLFALCDIPAGMELTFNY 1261
Cdd:cd20071   62 SCDPNAV---VVFDGNGTLRVRALRDIKAGEELTISY 95

SET_SpSet7-like

cd10540

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...

1148-1262

4.55e-08

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).

Pssm-ID: 380938 Cd Length: 112 Bit Score: 52.64 E-value: 4.55e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1148 EIIKTERRGWGLRTKRSIKKGEFVneyvgelidEEECRLRIKraheNSVTNFYMLTVTKDRIIDAG------PKGNYSRF 1221
Cdd:cd10540    3 EVKPSTLKGRGVFATRPIKKGEVI---------EEAPVIVLP----KEEYQHLCKTVLDHYVFSWGdgclalALGYGSMF 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 74761342 1222 mNHSCNPNCEtqKWTVNGDVRVGLFALCDIPAGMELTFNYN 1262
Cdd:cd10540   70 -NHSYTPNAE--YEIDFENQTIVFYALRDIEAGEELTINYG 107

PHD4_NSD

cd15567

PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

1323-1362

4.90e-08

Pssm-ID: 277042 [Multi-domain] Cd Length: 41 Bit Score: 50.32 E-value: 4.90e-08

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLNLTQPPYGKWEC 1362
Cdd:cd15567    1 WCFICSEGGSLICCES--CPASFHPECLGLEPPPEGKFYC 38

PWWP_ScIOC4-like

cd05840

PWWP domain found in Saccharomyces cerevisiae ISWI one complex protein 4 (ScIOC4) and similar ...

271-329

6.12e-08

PWWP domain found in Saccharomyces cerevisiae ISWI one complex protein 4 (ScIOC4) and similar proteins; ScIOC4 functions as a component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing. The family also includes Schizosaccharomyces pombe PWWP domain-containing proteins 1 and 2 (SpPDP1 and SpPDP2). SpPDP1 associates with Set9 to regulate its chromatin localization and methyltransferase activity towards H4K20. Members of this family contain a PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438965 Cd Length: 94 Bit Score: 51.53 E-value: 6.12e-08

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74761342  271 GDLVWSKVGTYPWWPCMVSSD---PQ--LEVHTKINTRGAREYHVQFFsNQPERAWVHEKRVRE 329
Cdd:cd05840    1 GDLVLAKVKGYPPWPAMVLPEellPKnvLKAKKRKPKSKKTVYPVQFF-PDNEYYWVSPSSLKP 63

PHD1_PHF12

cd15533

PHD finger 1 found in PHD finger protein 12 (PHF12); PHF12, also termed PHD factor 1 (Pf1), is ...

917-952

7.36e-08

PHD finger 1 found in PHD finger protein 12 (PHF12); PHF12, also termed PHD factor 1 (Pf1), is a plant homeodomain (PHD) zinc finger-containing protein that bridges the transducin-like enhancer of split (TLE) corepressor to the mSin3A-histone deacetylase (HDAC)-complex, and further represses transcription at targeted genes. PHF12 also interacts with MRG15 (mortality factor-related genes on chromosome 15), a member of the mortality factor (MORF) family of proteins implicated in regulating cellular senescence. PHF12 contains two plant-homeodomain (PHD) zinc fingers followed by a polybasic region. The PHD fingers function downstream of phosphoinositide signaling triggered by the interaction between polybasic regions and phosphoinositides. This model corresponds to the first PHD finger.

Pssm-ID: 277008 [Multi-domain] Cd Length: 45 Bit Score: 50.05 E-value: 7.36e-08

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 74761342  917 CEKGGRLLCCESCPASFHPECLS-----IEMPEGCWNCNDC 952
Cdd:cd15533    5 CGEGGDLLCCDRCPASFHLQCCNppldeEDLPPGEWLCHRC 45

PWWP_GLYR1

cd05836

PWWP domain found in glyoxylate reductase 1 (GLYR1) and similar proteins; GLYR1, also called ...

268-347

9.71e-08

Pssm-ID: 438961 [Multi-domain] Cd Length: 86 Bit Score: 51.07 E-value: 9.71e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMVSSDPQlevHTKINTRGAREYHVQFFSNQpERAWVHEKRVREYKGHKqyEELLAEATKQA 347
Cdd:cd05836    1 FKIGDLVWAKMKGFPPWPGKIVNPPP---DLKKPPRKKKMHCVYFFGSE-NYAWIEDENIKPYEEFK--EEMLKSKKSAG 74

SET_SpSET3-like

cd19183

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...

1158-1264

1.19e-07

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.

Pssm-ID: 380960 Cd Length: 173 Bit Score: 53.18 E-value: 1.19e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1158 GLRTKRSIKKGEFVNEYVGELideeecrlRIKRAHENSVTNFY-MLTVTKDRI---------IDAGPKGNYSRFMNHSCN 1227
Cdd:cd19183   15 GLFADRPIPAGDPIQELLGEI--------GLQSEYIADPENQYqILGAPKPHVffhpqsplyIDTRRSGSVARFIRRSCR 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 74761342 1228 PNCE--TQKWTVNGDVRVGLFALCDIPAGMELTFNYNLD 1264
Cdd:cd19183   87 PNAElvTVASDSGSVLKFVLYASRDISPGEEITIGWDWD 125

SET_SETD5

cd19181

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...

1159-1280

2.09e-07

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.

Pssm-ID: 380958 Cd Length: 150 Bit Score: 51.93 E-value: 2.09e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1159 LRTKRSIKKGEFVNEYVGELIDEEECRLR---IKRAHENSVtnFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKW 1235
Cdd:cd19181   21 LRAARDLALDTLIIEYRGKVMLRQQFEVNghfFKRPYPFVL--FYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHM 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 74761342 1236 TVNGDVRVGLFALCDIPAGMELTF---------NYNLDClgngrtECHCGADNC 1280
Cdd:cd19181   99 IADGMIHLCIYAVAAIAKDAEVTIafdyeysncNYKVDC------ACHKGNRNC 146

PWWP_ScIOC4-like

cd05840

PWWP domain found in Saccharomyces cerevisiae ISWI one complex protein 4 (ScIOC4) and similar ...

962-1044

2.78e-07

Pssm-ID: 438965 Cd Length: 94 Bit Score: 49.99 E-value: 2.78e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  962 QIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGD-----FPVFFFGSHDYYWVHQGRVFPYVEGD-KSFAEGQTSINK 1035
Cdd:cd05840    2 DLVLAKVKGYPPWPAMVLPEELLPKNVLKAKKRKPKskktvYPVQFFPDNEYYWVSPSSLKPLTKEEiDKFLSKSKRKNK 81


                 ....*....
gi 74761342 1036 TFKKALEEA 1044
Cdd:cd05840   82 DLIEAYEVA 90

PHD1_Rco1

cd15535

PHD finger 1 found in Saccharomyces cerevisiae transcriptional regulatory protein Rco1 and ...

917-952

4.12e-07

PHD finger 1 found in Saccharomyces cerevisiae transcriptional regulatory protein Rco1 and similar proteins; Rco1 is a component of the Rpd3S histone deacetylase complex that plays an important role at actively transcribed genes. Rco1 contains two plant homeodomain (PHD) fingers, which are required for the methylation of histone H3 lysine 36 (H3K36) nucleosome recognition by Rpd3S. This model corresponds to the first PHD finger.

Pssm-ID: 277010 [Multi-domain] Cd Length: 45 Bit Score: 47.80 E-value: 4.12e-07

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSI-----EMPEGCWNCNDC 952
Cdd:cd15535    5 CGGYGSFLCCDGCPRSFHFSCLDPpleedNLPDDEWFCNEC 45

PWWP_NSD_rpt2

cd05838

second PWWP domain found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

270-348

8.25e-07

Pssm-ID: 438963 [Multi-domain] Cd Length: 96 Bit Score: 48.39 E-value: 8.25e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  270 VGDLVWSKVGTYPWWPCMVsSDPQlEVHTKI--NTRGAREYHVQFF-SNqpERAWVHEKRVREY---------KGHKQYE 337
Cdd:cd05838    2 YGDIVWVKLGNYRWWPAEI-LHPR-EVPDNIqsLPHPPGEFPVRFFgSH--DYYWVHRGRVFLFeegdkgskeKSKKSLD 77

                         90
                 ....*....|.
gi 74761342  338 ELLAEATKQAS 348
Cdd:cd05838   78 KSFKRALKEAN 88

PHD1_PHF12

cd15533

PHD finger 1 found in PHD finger protein 12 (PHF12); PHF12, also termed PHD factor 1 (Pf1), is ...

1323-1367

9.99e-07

Pssm-ID: 277008 [Multi-domain] Cd Length: 45 Bit Score: 46.58 E-value: 9.99e-07

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLN----LTQPPYGKWECpwHQC 1367
Cdd:cd15533    1 YCDSCGEGGDLLCCDR--CPASFHLQCCNppldEEDLPPGEWLC--HRC 45

PHD_ING3

cd15585

PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins; ING3, also ...

1331-1367

1.47e-06

PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins; ING3, also termed p47ING3, is one member of the inhibitor of growth (ING) family of type II tumor suppressors. It is ubiquitously expressed and has been implicated in transcription modulation, cell cycle control, and the induction of apoptosis. It is an important subunit of human NuA4 histone acetyltransferase complex, which regulates the acetylation of histones H2A and H4. Moreover, ING3 promotes ultraviolet (UV)-induced apoptosis through the Fas/caspase-8-dependent pathway in melanoma cells. It physically interacts with subunits of E3 ligase Skp1-Cullin-F-boxprotein complex (SCF complex) and is degraded by the SCF (F-box protein S-phase kinase-associated protein 2, Skp2)-mediated ubiquitin-proteasome system. It also acts as a suppression factor during tumorigenesis and progression of hepatocellular carcinoma (HCC). ING3 contains an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.

Pssm-ID: 277060 [Multi-domain] Cd Length: 45 Bit Score: 46.29 E-value: 1.47e-06

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 74761342 1331 GELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECPwhQC 1367
Cdd:cd15585   10 GEMVGCDNDDCPiEWFHYGCVGLTEAPKGKWYCP--QC 45

PWWP_BRPF

cd05839

PWWP domain found in the bromodomain and PHD finger-containing (BRPF) protein family; The BRPF ...

268-358

1.56e-06

PWWP domain found in the bromodomain and PHD finger-containing (BRPF) protein family; The BRPF family of proteins includes BRPF1, BRD1/BRPF2, and BRPF3. They are scaffold proteins that form monocytic leukemic zinc-finger protein (MOZ)/MOZ-related factor (MORF) H3 histone acetyltransferase (HAT) complexes with other regulatory subunits, such as inhibitor of growth 5 (ING5) and Esa1-associated factor 6 ortholog (EAF6). BRPF proteins have multiple domains, including a plant homeodomain (PHD) zinc finger followed by a non-canonical extended PHD (ePHD) finger, C2HC5HC2H, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. The PHD finger binds to lysine 4 of histone H3 (K4H3), the bromodomain interacts with acetylated lysines on N-terminal tails of histones and other proteins, and the PWWP domain shows histone-binding and chromatin association properties.

Pssm-ID: 438964 Cd Length: 106 Bit Score: 48.03 E-value: 1.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMV--SSDPQLEVHTKINT--------RGAREYHVQFFSNQPERAWVHEKRVREYKGHKQY- 336
Cdd:cd05839    1 LEPGDLVWAKCRGYPWYPAEIvdPKDPKEGNGVPIPVppdrvlkkSNEKLYLVLFFDAKRTWGWLPRNKLRPLGVDEELd 80

                         90       100
                 ....*....|....*....|..
gi 74761342  337 EELLAEATKQasnhSEKQKIRK 358
Cdd:cd05839   81 KLKLSEAKKS----KRRKEVRK 98

PWWP_ZCWPW2

cd20146

PWWP domain found in zinc finger CW-type PWWP domain protein 2 (ZCWPW2) and similar proteins; ...

955-1051

2.00e-06

Pssm-ID: 438974 Cd Length: 113 Bit Score: 48.06 E-value: 2.00e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  955 GKKLHYKQ-----IVWVKLGNYRWWPAEICNPrsvPLNIQGLKHDLGDFP----VFFFGS-HDYYWVHQGRVFPYVEG-- 1022
Cdd:cd20146    1 GLKYVYSQlplgsLVWAKMTGYPRWPAILTPD---PICGEYVDYDEDGEVekyhVEFLGKpHSHAWISAKSVEPYNSNtk 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 74761342 1023 -DKSFAEGQTSINKTFKKALEEaAKRFQEL 1051
Cdd:cd20146   78 tPKCKTKKSKKRKKSYESALEE-AERLLKL 106

TNG2

COG5034

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

1288-1374

5.21e-06

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

Pssm-ID: 227367 [Multi-domain] Cd Length: 271 Bit Score: 49.94 E-value: 5.21e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1288 PKSACASTNEEKAKNAKLKQKRRKIKTEPKQMhedYCF-QCGDGGELVMCDKKDCPKA-YHLLCLNLTQPPYGKWECPwh 1365
Cdd:COG5034  191 PDTATRVKEGNNGGSTKSRGVSSEDNSEGEEL---YCFcQQVSYGQMVACDNANCKREwFHLECVGLKEPPKGKWYCP-- 265


                 ....*....
gi 74761342 1366 qcdECSSAA 1374
Cdd:COG5034  266 ---ECKKAA 271

ADDz_Dnmt3

cd11725

ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3 (Dnmt3); Dnmt3 is a de ...

1321-1363

6.73e-06

ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3 (Dnmt3); Dnmt3 is a de novo DNA methyltransferase family that includes two active enzymes Dnmt3a and -3b and one regulatory factor Dnmt3l. The ADDz domain of Dnmt3 is located in the C-terminal region of Dnmt3, which is an active catalytic domain in Dnmt3a and -b, but lacks some residues for enzymatic activity in Dnmt3l. DNA methylation is an important epigenetic mechanism involved in diverse biological processes such as embryonic development, gene expression, and genomic imprinting. The ADDz_Dnmt3 domain is a PHD-like zinc finger motif that contains two parts, a C2-C2 and a PHD-like zinc finger. PHD zinc finger domains have been identified in more than 40 proteins that are mainly involved in chromatin mediated transcriptional control; the classical PHD zinc finger has a C4-H-C3 motif that spans about 50-80 amino acids. In ADDz, the conserved histidine residue of the PHD finger is replaced by a cysteine, and an additional zinc finger C2-C2 like motif is located about twenty residues upstream of the C4-C-C3 motif.

Pssm-ID: 277251 [Multi-domain] Cd Length: 108 Bit Score: 46.23 E-value: 6.73e-06

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 74761342 1321 EDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPY--------GKWECP 1363
Cdd:cd11725   47 QMYCTICGGGGEVVLCDNPDCTRVYCTECLDLLLGPGavakilesDPWFCF 97

PWWP_PWWP2

cd20140

PWWP domain found in the PWWP domain-containing protein 2 (PWWP2) family; The PWWP2 family ...

265-290

1.03e-05

PWWP domain found in the PWWP domain-containing protein 2 (PWWP2) family; The PWWP2 family includes PWWP2A and its paralog PWWP2B. PWWP2A is a H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. It is also required for proper mitosis progression. PWWP2A and PWWP2B form a stable complex with NuRD subunits MTA1/2/3:HDAC1/2:RBBP4/7, but not with MBD2/3, p66alpha/beta, and CHD3/4. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438968 Cd Length: 92 Bit Score: 45.33 E-value: 1.03e-05

                         10        20
                 ....*....|....*....|....*.
gi 74761342  265 GVKFQVGDLVWSKVGTYPWWPCMVSS 290
Cdd:cd20140    1 GRTLRVGDIVWGKIHGFPWWPGRILS 26

PHD1_BPTF

cd15559

PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF); BPTF, ...

917-952

1.09e-05

PHD finger 1 found in bromodomain and PHD finger-containing transcription factor (BPTF); BPTF, also termed nucleosome-remodeling factor subunit BPTF, or fetal Alz-50 clone 1 protein (FAC1), or fetal Alzheimer antigen, functions as a transcriptional regulator that exhibits altered expression and subcellular localization during neuronal development and neurodegenerative diseases such as Alzheimer's disease. It interacts with the human orthologue of the Kelch-like Ech-associated protein (Keap1). Its function and subcellular localization can be regulated by Keap1. Moreover, BPTF is a novel DNA-binding protein that recognizes the DNA sequence CACAACAC and represses transcription through this site in a phosphorylation-dependent manner. Furthermore, BPTF interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity, which has been implicated in gene regulation in neurodegeneration. Some family members contain two or three plant homeodomain (PHD) fingers, which may be involved in complex formation with histone H3 trimethylated at K4 (H3K4me3). This family corresponds to the first PHD finger.

Pssm-ID: 277034 [Multi-domain] Cd Length: 43 Bit Score: 43.56 E-value: 1.09e-05

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCESCPASFHPECLS---IEMPEGCWNCNDC 952
Cdd:cd15559    5 CHKLGDLLCCETCSAVYHLECVDpplEEVPEEDWQCEVC 43

PWWP_AtATX3-like

cd20143

PWWP domain found in Arabidopsis thaliana histone-lysine N-methyltransferase trithorax-like ...

269-322

1.16e-05

Pssm-ID: 438971 [Multi-domain] Cd Length: 100 Bit Score: 45.44 E-value: 1.16e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74761342  269 QVGDLVWSKVGTYPWWP-CMV--SSDPQLEVHTKINTRGAreyhVQFFSNQPER--AWV 322
Cdd:cd20143    1 VEGDLVWAKVGTHPFWPaRVVepAEQAEEVRRRCVPGSLC----VYFFGPGGSRdyGWV 55

PHD_ING

cd15505

PHD finger found in the inhibitor of growth (ING) protein family; The ING family includes a ...

1323-1363

1.21e-05

PHD finger found in the inhibitor of growth (ING) protein family; The ING family includes a group of tumor suppressors, ING1-5, which act as readers and writers of the histone epigenetic code, affecting DNA damage response, chromatin remodeling, cellular senescence, differentiation, cell cycle regulation and apoptosis. They may have a general role in mediating the cellular response to genotoxic stress through binding to and regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC) chromatin remodeling complexes. All ING proteins contain an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.

Pssm-ID: 276980 [Multi-domain] Cd Length: 45 Bit Score: 43.83 E-value: 1.21e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCF-QCGDGGELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15505    1 YCIcNQVSYGEMVACDNPNCPiEWFHFECVGLTAKPKGKWYCP 43

PWWP_HRP

cd05834

PWWP domain found in hepatoma-derived growth factor (HDGF)-related protein (HRP) family; The ...

268-334

1.23e-05

Pssm-ID: 438959 [Multi-domain] Cd Length: 82 Bit Score: 44.85 E-value: 1.23e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74761342  268 FQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINtrgareYHVQFFSNqPERAWVHEKRVREYKGHK 334
Cdd:cd05834    1 FKPGDLVFAKVKGYPPWPARIDEIPEGAKIPKNK------YPVFFYGT-HETAFLKPKDLFPYEENK 60

PWWP_NSD3_rpt1

first PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar proteins; ...

963-1068

1.67e-05

Pssm-ID: 438991 Cd Length: 130 Bit Score: 45.69 E-value: 1.67e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPAEI-CNPRS---VPLNIQGLKhdlgDFPVFFFGSH-DYYWVHQGRVFPYvEGDKSFAEGQTsinKTF 1037
Cdd:cd20163    6 LVWSKVGTYPWWPCMVsSDPQLevhTKINTRGAR----EYHVQFFSSQpERAWVHEKRVREY-KGHKQYEELLA---EAT 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 74761342 1038 KKALEEAAK------RFQELKAQRE-----SKEALEIEKNSR 1068
Cdd:cd20163   78 KQASNHSEKqkirkpRPQRERAQWDigiahAEKALKMTREER 119

PHD

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...

915-953

1.68e-05

Pssm-ID: 425785 [Multi-domain] Cd Length: 51 Bit Score: 43.63 E-value: 1.68e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 74761342    915 KKCEKGGRLLCCESCPASFHPECLSI-----EMPEGCWNCNDCK 953
Cdd:pfam00628    6 GKSDDGGELVQCDGCDDWFHLACLGPpldpaEIPSGEWLCPECK 49

PHD_TIF1_like

cd15541

PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar ...

1323-1362

2.52e-05

PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins; The TIF1 family of transcriptional cofactors includes TIF1alpha (TRIM24), TIF1beta (TRIM28), TIF1gamma (TRIM33), and TIF1delta (TRIM66), which are characterized by an N-terminal RING-finger B-box coiled-coil (RBCC/TRIM) motif and plant homeodomain (PHD) finger followed by a bromodomain in the C-terminal region. TIF1 proteins couple chromatin modifications to transcriptional regulation, signaling, and tumor suppression. They exert a deacetylase-dependent silencing effect when tethered to a promoter region. TIF1alpha, TIF1beta, and TIF1delta can homodimerize and contain a PXVXL motif necessary and sufficient for heterochromatin protein 1(HP1) binding. TIF1alpha and TIF1beta bind nuclear receptors and Kruppel-associated boxes (KRAB) specifically and respectively. In contrast, TIF1delta appears to lack nuclear receptor- and KRAB-binding activity. Moreover, TIF1delta is specifically involved in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis. TIF1gamma is structurally closely related to TIF1alpha and TIF1beta, but has very little functional features in common with them. It does not interact with the KRAB silencing domain of KOX1 or the heterochromatinic proteins HP1alpha, beta, and gamma. It cannot bind to nuclear receptors (NRs). This family also includes Sp100/Sp140 family proteins, the nuclear body SP100 and SP140. Sp110 is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. SP140 is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus viral infectivity factor (Vif) protein. Both Sp110 and Sp140 contain a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD).

Pssm-ID: 277016 [Multi-domain] Cd Length: 43 Bit Score: 42.72 E-value: 2.52e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCL--NLTQPPYGKWEC 1362
Cdd:cd15541    1 WCAVCQNGGELLCCDK--CPRVFHLDCHipPIPEFPSGEWSC 40

PHD

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...

915-952

2.55e-05

Pssm-ID: 214584 [Multi-domain] Cd Length: 47 Bit Score: 42.97 E-value: 2.55e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 74761342     915 KKCEKGGRLLCCESCPASFHPECLSI----EMPEGCWNCNDC 952
Cdd:smart00249    6 GKPDDGGELLQCDGCDRWYHQTCLGPplleEEPDGKWYCPKC 47

PHD_PHF21A

cd15523

PHD finger found in PHD finger protein 21A (PHF21A); PHF21A (also termed BHC80a or BRAF35-HDAC ...

1323-1363

2.61e-05

PHD finger found in PHD finger protein 21A (PHF21A); PHF21A (also termed BHC80a or BRAF35-HDAC complex protein BHC80) along with HDAC1/2, CtBP1, CoREST, and BRAF35, is associated with LSD1, a lysine (K)-specific histone demethylase. It inhibits LSD1-mediated histone demethylation in vitro. PHF21A is predominantly present in the central nervous system and spermatogenic cells and is one of the six components of BRAF-HDAC complex (BHC) involved in REST-dependent transcriptional repression of neuron-specific genes in non-neuronal cells. It acts as a scaffold protein in BHC in neuronal as well as non-neuronal cells and also plays a role in spermatogenesis. PHF21A contains a C-terminal plant homeodomain (PHD) finger that is responsible for the binding directly to each of five other components of BHC, and of organizing BHC mediating transcriptional repression.

Pssm-ID: 276998 [Multi-domain] Cd Length: 43 Bit Score: 42.77 E-value: 2.61e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLN--LTQPPYGKWECP 1363
Cdd:cd15523    1 FCSVCRKSGELLMCDT--CSLVYHLDCLDppLKTIPKGMWICP 41

PHD4_NSD

cd15567

PHD finger 4 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

704-745

2.74e-05

Pssm-ID: 277042 [Multi-domain] Cd Length: 41 Bit Score: 42.62 E-value: 2.74e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 74761342  704 CQICeSSGDSLIPCEGeCCKHFHLECLGLASLPDSKFICMEC 745
Cdd:cd15567    2 CFIC-SEGGSLICCES-CPASFHPECLGLEPPPEGKFYCEDC 41

PHD1_CHD_II

cd15531

PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins; Class II CHD ...

917-952

2.81e-05

Pssm-ID: 277006 [Multi-domain] Cd Length: 43 Bit Score: 42.59 E-value: 2.81e-05

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIEM---PEGCWNCNDC 952
Cdd:cd15531    5 CQQGGEIILCDTCPRAYHLVCLDPELekaPEGKWSCPHC 43

PWWP_HDGF

cd20148

PWWP domain found in Hepatoma-derived growth factor (HDGF); HDGF, also called high mobility ...

963-1043

2.82e-05

PWWP domain found in Hepatoma-derived growth factor (HDGF); HDGF, also called high mobility group protein 1-like 2 (HMG-1L2), is a heparin-binding protein that acts as a transcriptional repressor with mitogenic activity for fibroblasts. It contains a PWWP domain, which is necessary for DNA binding.

Pssm-ID: 438976 [Multi-domain] Cd Length: 87 Bit Score: 43.86 E-value: 2.82e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPAEIcnpRSVPLNiqGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFaeGQTSINKTFKKALE 1042
Cdd:cd20148    6 LVFAKMKGYPHWPARI---DEMPEA--AVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKF--GKPNKRKGFSEGLW 78


                 .
gi 74761342 1043 E 1043
Cdd:cd20148   79 E 79

PWWP_MSH6

cd05837

PWWP domain found in DNA mismatch repair protein MSH6 and similar proteins; MSH6, also called ...

962-1058

3.84e-05

Pssm-ID: 438962 Cd Length: 103 Bit Score: 44.20 E-value: 3.84e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  962 QIVWVKLGNYRWWPAEICNPrsvPLNIQGLKHD-LGDFPVFFFG---SHDyyWVHQGRVFPYVEG-DKSFAEG--QTSIN 1034
Cdd:cd05837    5 DLVWAKLEGYPWWPSLVCNH---PTTGFHKKFGkKGEVHVQFFDdppSRA--WVKAKNVKPFTGSdDKEFQKGgmFFSKD 79

                         90       100
                 ....*....|....*....|....
gi 74761342 1035 KTFKKALEEAAKRFQELKAQRESK 1058
Cdd:cd05837   80 PKWKKAVKEADKALKLSVEERLKL 103

SET_ATXR5_6-like

cd10539

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...

1154-1262

3.90e-05

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.

Pssm-ID: 380937 Cd Length: 138 Bit Score: 45.09 E-value: 3.90e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1154 RRGWGLRTKRSIKKGEFVNEYVGElIDEEECRLRIKR-------AHENSVTNfymLTVTKDRiidagpKGNYSRFM---- 1222
Cdd:cd10539   13 REGFTVEADGFIKDLTIIAEYTGD-VDYIRNREFDDNdsimtllLAGDPSKS---LVICPDK------RGNIARFIsgin 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 74761342 1223 NHSCN----PNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYN 1262
Cdd:cd10539   83 NHTKDgkkkQNCKCVRYSINGEARVLLVATRDIAKGERLYYDYN 126

PHD_PRKCBP1

cd15538

PHD finger found in protein kinase C-binding protein 1 (PRKCBP1); PRKCBP1, also termed ...

1323-1363

5.20e-05

PHD finger found in protein kinase C-binding protein 1 (PRKCBP1); PRKCBP1, also termed cutaneous T-cell lymphoma-associated antigen se14-3 (CTCL-associated antigen se14-3), or Rack7, or zinc finger MYND domain-containing protein 8 (ZMYND8), is a novel receptor for activated C-kinase (RACK)-like protein that may play an important role in the activation and regulation of PKC-beta I, and the PKC signaling cascade. It also has been identified as a formin homology-2-domain containing protein 1 (FHOD1)-binding protein that may be involved in FHOD1-regulated actin polymerization and transcription. Moreover, PRKCBP1 may function as a REST co-repressor 2 (RCOR2) interacting factor; the RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation. PRKCBP1 contains a plant homeodomain (PHD) finger, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain.

Pssm-ID: 277013 Cd Length: 41 Bit Score: 41.93 E-value: 5.20e-05

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15538    1 FCWRCHKEGQVLCCSL--CPRVYHKKCLKLTSEPDEDWVCP 39

PWWP_NSD_rpt1

cd20144

first PWWP domain found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

962-1067

5.67e-05

Pssm-ID: 438972 Cd Length: 114 Bit Score: 43.84 E-value: 5.67e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  962 QIVWVKLGNYRWWPAEICNPrsvPLN--------IQGLKHDLgdFPVFFFGSHD-YYWVHQGRVFPYvegdksfaEGQTS 1032
Cdd:cd20144    3 DLVWAKVSGHPWWPCMVTYD---PESglytkikgSGGRTYRQ--YHVQFFGDNGeRGWVSEKSLMPF--------EGKEK 69

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 74761342 1033 INKTFKKALEEAAKRFQELKAQRESKEALEIEKNS 1067
Cdd:cd20144   70 FEELVKELKKKAKKKSKKAKLEKKVKPSRRKKWEI 104

PHD

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...

1323-1373

6.32e-05

Pssm-ID: 425785 [Multi-domain] Cd Length: 51 Bit Score: 41.71 E-value: 6.32e-05

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 74761342   1323 YCFQCG---DGGELVMCDkkDCPKAYHLLCLNLTQPPYGKWECPWhQCDECSSA 1373
Cdd:pfam00628    1 YCAVCGksdDGGELVQCD--GCDDWFHLACLGPPLDPAEIPSGEW-LCPECKPK 51

PHD

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...

1323-1365

6.48e-05

Pssm-ID: 214584 [Multi-domain] Cd Length: 47 Bit Score: 41.81 E-value: 6.48e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 74761342    1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLNLT---QPPYGKWECPWH 1365
Cdd:smart00249    4 VCGKPDDGGELLQCDG--CDRWYHQTCLGPPlleEEPDGKWYCPKC 47

PWWP_AtATX1-like

cd20142

PWWP domain found in Arabidopsis thaliana histone-lysine N-methyltransferase trithorax-like ...

963-1052

7.57e-05

PWWP domain found in Arabidopsis thaliana histone-lysine N-methyltransferase trithorax-like proteins ATX1, ATX2, and similar proteins; This family includes A. thaliana ATX1 and ATX2, which are sister paralogs originating from a segmental chromosomal duplication. They are plant counterparts of the Drosophila melanogaster trithorax (TRX) and mammalian mixed-lineage leukemia (MLL1) proteins. ATX1, also called protein SET domain group 27, or trithorax-homolog protein 1 (TRX-homolog protein 1), is a methyltransferase that trimethylates histone H3 at lysine 4 (H3K4me3). It also acts as a histone modifier and as a positive effector of gene expression. ATX1 regulates transcription from diverse classes of genes implicated in biotic and abiotic stress responses. It is involved in dehydration stress signaling in both abscisic acid (ABA)-dependent and ABA-independent pathways. ATX2, also called protein SET domain group 30, or trithorax-homolog protein 2 (TRX-homolog protein 2), is involved in dimethylating histone H3 at lysine 4 (H3K4me2). Both ATX1 and ATX2 are multi-domain containing proteins that consist of an N-terminal PWWP domain, FYRN- and FYRC (DAST, domain associated with SET in trithorax) domains, a canonical plant homeodomain (PHD) domain, a non-canonical extended PHD (ePHD) domain, and a C-terminal SET domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438970 [Multi-domain] Cd Length: 97 Bit Score: 43.11 E-value: 7.57e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPA-----EICNPRSVPLNIQGLKHDLgdfPVFFFGSHDYYWVHQGRVFPYVEG-DKSFaeGQTSINKT 1036
Cdd:cd20142    5 VVWAKVKGYPMWPAlvideEHAERCGLEANRPGKKGTV---PVQFFGTYEVARLNPKKVVGFSKGlDLKY--HSKCKAPV 79

                         90
                 ....*....|....*.
gi 74761342 1037 FKKALEEAAKRFQELK 1052
Cdd:cd20142   80 FRQALEEAERYLKEGK 95

PHD_ING4_5

cd15586

PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5); ING4, also termed ...

1331-1363

1.03e-04

PHD finger found in inhibitor of growth protein 4 (ING4) and 5 (ING5); ING4, also termed p29ING4, and ING5, also termed p28ING5, belong to the inhibitor of growth (ING) family of type II tumor suppressors. ING4 acts as an E3 ubiquitin ligase to induce ubiquitination of the p65 subunit of NF-kappaB and inhibit the transactivation of NF-kappaB target genes. It also induces apoptosis through a p53 dependent pathway, including increasing p53 acetylation, inhibiting Mdm2-mediated degradation of p53 and enhancing the expression of p53 responsive genes both at the transcriptional and post-translational levels. Moreover, ING4 can inhibit the translation of proto-oncogene MYC by interacting with AUF1. It also regulates other transcription factors, such as hypoxia-inducible factor (HIF). ING5 is a Tip60 cofactor that acetylates p53 at K120 and subsequently activates the expression of p53-dependent apoptotic genes in response to DNA damage. Aberrant ING5 expression may contribute to pathogenesis, growth, and invasion of gastric carcinomas and colorectal cancer. ING5 can physically interact with p300 and p53 in vivo, and its overexpression induces apoptosis in colorectal cancer cells. It also associates with cyclin A1 (INCA1) and functions as a growth suppressor with suppressed expression in Acute Myeloid Leukemia (AML). Moreover, ING5 translocation from the nucleus to the cytoplasm might be a critical event for carcinogenesis and tumor progression in human head and neck squamous cell carcinoma. Both ING4 and ING5 contain an N-terminal ING histone-binding domain and a C-terminal plant homeodomain (PHD) finger. They associate with histone acetyltransferase (HAT) complexes containing MOZ (monocytic leukemia zinc finger protein)/MORF (MOZ-related factor) and HBO1, and further direct the MOZ/MORF and HBO1 complexes to chromatin.

Pssm-ID: 277061 [Multi-domain] Cd Length: 45 Bit Score: 41.02 E-value: 1.03e-04

                         10        20        30
                 ....*....|....*....|....*....|....
gi 74761342 1331 GELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15586   10 GEMIGCDNPDCPiEWFHFACVGLTTKPKGKWFCP 43

PWWP_BS69-like

cd05841

PWWP domain found in protein BS69, protein kinase C-binding protein 1 (PRKCBP1) and similar ...

963-1045

1.07e-04

PWWP domain found in protein BS69, protein kinase C-binding protein 1 (PRKCBP1) and similar proteins; Protein BS69, also called zinc finger MYND domain-containing protein 11 (ZMYND11 or ZMY11), is a ubiquitously expressed nuclear protein acting as a transcriptional co-repressor in association with various transcription factors. It was originally identified as an adenovirus 5 E1A-binding protein that inhibits E1A transactivation, as well as c-Myb transcription. BS69 is a multi-domain protein, containing bromo, plant homeodomain (PHD), proline-tryptophan-tryptophan-proline (PWWP), and MYeloid translocation protein 8, Nervy and DEAF-1 (MYND) domains. The specific role of the PWWP domain within BS69 is not clearly identified, but BS69 functions in chromatin remodeling, consistent with other PWWP-containing proteins. PRKCBP1, also called cutaneous T-cell lymphoma-associated antigen se14-3 (CTCL-associated antigen se14-3), Rack7, or zinc finger MYND domain-containing protein 8 (ZMYND8), is a novel receptor for activated C-kinase (RACK)-like protein that may play an important role in the activation and regulation of PKC-beta I, and the PKC signaling cascade. It also has been identified as a formin homology-2-domain containing protein 1 (FHOD1)-binding protein that may be involved in FHOD1-regulated actin polymerization and transcription. Moreover, PRKCBP1 may function as a REST co-repressor 2 (RCOR2) interacting factor. They form a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation. PRKCBP1 contains a PHD finger, a bromodomain, and a PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438966 Cd Length: 89 Bit Score: 42.38 E-value: 1.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPAEIcnprsvplnIQGLKHDLgdfPVFFFGSHDYYWVHQGRVFPY-VEG-DKSFAEGQTSINKTFKKA 1040
Cdd:cd05841    9 LVWVKLDGFPFWPAKV---------MGTKDGQV---DVRFFGDYDRAWLPSKNVTLHtREIvSTLPDSSESKDKRTLKKA 76


                 ....*
gi 74761342 1041 LEEAA 1045
Cdd:cd05841   77 IKELE 81

SET_KMT2E

cd19182

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...

1210-1264

1.13e-04

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.

Pssm-ID: 380959 Cd Length: 129 Bit Score: 43.34 E-value: 1.13e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 74761342 1210 IDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLD 1264
Cdd:cd19182   73 VDARTFGNEARFIRRSCTPNAEVRHVIEDGTIHLYIYSIRSIPKGTEITIAFDFD 127

PWWP_NSD3_rpt2

second PWWP domain found in nuclear SET domain-containing protein 3 (NSD3) and similar ...

272-346

1.34e-04

Pssm-ID: 438994 Cd Length: 95 Bit Score: 42.27 E-value: 1.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  272 DLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQpERAWVHEKRVREY------------KGHKQYEEL 339
Cdd:cd20166    4 QIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDIGDFPVFFFGSH-DYYWVHQGRVFPYvegdksfaegqtSINKTFKKA 82


                 ....*..
gi 74761342  340 LAEATKQ 346
Cdd:cd20166   83 LEEAAKR 89

PWWP_PSIP

cd20151

PWWP domain found in PC4 and SFRS1-interacting protein (PSIP); PSIP, also called ...

963-1043

1.80e-04

PWWP domain found in PC4 and SFRS1-interacting protein (PSIP); PSIP, also called CLL-associated antigen KW-7, dense fine speckles 70 kDa protein (DFS 70), lens epithelium-derived growth factor (LEDGF), or transcriptional coactivator p75/p52, acts as a transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. It contains a PWWP domain, which is necessary for DNA binding.

Pssm-ID: 438979 [Multi-domain] Cd Length: 88 Bit Score: 41.89 E-value: 1.80e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPAEIcnpRSVPLNiqGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFaeGQTSINKTFKKALE 1042
Cdd:cd20151    6 LIFAKMKGYPHWPARV---DEVPDG--AVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKY--GKPNKRKGFNEGLW 78


                 .
gi 74761342 1043 E 1043
Cdd:cd20151   79 E 79

PHD_ING5

cd15685

PHD finger found in inhibitor of growth protein 5 (ING5); ING5, also termed p28ING5, is one ...

1331-1363

1.83e-04

PHD finger found in inhibitor of growth protein 5 (ING5); ING5, also termed p28ING5, is one member of the inhibitor of growth (ING) family of type II tumor suppressors. It acts as a Tip60 cofactor that acetylates p53 at K120 and subsequently activates the expression of p53-dependent apoptotic genes in response to DNA damage. Aberrant ING5 expression may contribute to pathogenesis, growth, and invasion of gastric carcinomas and colorectal cancer. ING5 can physically interact with p300 and p53 in vivo, and its overexpression induces apoptosis in colorectal cancer cells. It also associates with cyclin A1 (INCA1) and functions as a growth suppressor with suppressed expression in Acute Myeloid Leukemia (AML). Moreover, ING5 translocation from the nucleus to the cytoplasm might be a critical event for carcinogenesis and tumor progression in human head and neck squamous cell carcinoma. In addition, ING5 associates with histone acetyltransferase (HAT) complexes containing MOZ (monocytic leukemia zinc finger protein)/MORF (MOZ-related factor) and HBO1, and further directs the MOZ/MORF and HBO1 complexes to chromatin. ING5 contains an N-terminal ING histone-binding domain and a C-terminal plant homeodomain (PHD) finger.

Pssm-ID: 277155 [Multi-domain] Cd Length: 49 Bit Score: 40.42 E-value: 1.83e-04

                         10        20        30
                 ....*....|....*....|....*....|....
gi 74761342 1331 GELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15685   11 GEMIGCDNPDCPiEWFHFACVDLTTKPKGKWFCP 44

PHD_TIF1delta

cd15625

PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta); TIF1delta, also ...

1320-1362

1.84e-04

PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta); TIF1delta, also termed tripartite motif-containing protein 66 (TRIM66), is a novel heterochromatin protein 1 (HP1)-interacting member of the transcriptional intermediary factor1 (TIF1) family expressed by elongating spermatids. Like other TIF1 proteins, TIF1delta displays a potent trichostatin A (TSA)-sensitive repression function; TSA is a specific inhibitor of histone deacetylases. Moreover, TIF1delta plays an important role in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis. It functions as a negative regulator of postmeiotic genes acting through HP1 isotype gamma (HP1gamma) complex formation and centromere association. TIF1delta contains an N-terminal RBCC (RING finger, B-box zinc-fingers, coiled-coil), a plant homeodomain (PHD) finger, followed by a bromodomain in the C-terminal region.

Pssm-ID: 277095 [Multi-domain] Cd Length: 49 Bit Score: 40.33 E-value: 1.84e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 74761342 1320 HEDYCFQCGDGGELVMCDKkdCPKAYHLLCL--NLTQPPYGKWEC 1362
Cdd:cd15625    1 NEDFCAVCLNGGELLCCDR--CPKVFHLSCHvpALLSFPVGEWVC 43

PWWP_PRKCBP1

cd20160

PWWP domain found in protein kinase C-binding protein 1 (PRKCBP1) and similar proteins; ...

963-1054

1.85e-04

PWWP domain found in protein kinase C-binding protein 1 (PRKCBP1) and similar proteins; PRKCBP1, also called cutaneous T-cell lymphoma-associated antigen se14-3 (CTCL-associated antigen se14-3), Rack7, or zinc finger MYND domain-containing protein 8 (ZMYND8), is a novel receptor for activated C-kinase (RACK)-like protein that may play an important role in the activation and regulation of PKC-beta I, and the PKC signaling cascade. It also has been identified as a formin homology-2-domain containing protein 1 (FHOD1)-binding protein that may be involved in FHOD1-regulated actin polymerization and transcription. Moreover, PRKCBP1 may function as a REST co-repressor 2 (RCOR2) interacting factor. They form a RCOR2/ZMYND8 complex which might be involved in the regulation of neural differentiation. PRKCBP1 contains a plant homeodomain (PHD) finger, a bromodomain, and a proline-tryptophan-tryptophan-proline (PWWP) domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438988 Cd Length: 91 Bit Score: 41.78 E-value: 1.85e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPAEIcnprsvplniqgLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSfaeGQTSINKTFKKALE 1042
Cdd:cd20160    9 LVWAKLKGFPFWPAKA------------LRVNNGQVDVRFFGAHDRAWVPVKDCYLYSKEPPT---SVKKKKSGLDEAME 73

                         90
                 ....*....|..
gi 74761342 1043 EAAKRFQELKAQ 1054
Cdd:cd20160   74 ELEIHIEKLREK 85

PHD_PHF21B

cd15524

PHD finger found in PHD finger protein 21B (PHF21B); PHF21B is a plant homeodomain (PHD) ...

1323-1363

2.62e-04

PHD finger found in PHD finger protein 21B (PHF21B); PHF21B is a plant homeodomain (PHD) finger-containing protein whose biological function remains unclear. It shows high sequence similarity with PHF21A, which is associated with LSD1, a lysine (K)-specific histone demethylase and inhibits LSD1-mediated histone demethylation in vitro. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins.

Pssm-ID: 276999 [Multi-domain] Cd Length: 43 Bit Score: 39.88 E-value: 2.62e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLN--LTQPPYGKWECP 1363
Cdd:cd15524    1 HCAACKRGGNLQPCGT--CPRAYHLDCLDppLKTAPKGVWVCP 41

PHD_SF

cd15489

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...

914-952

2.62e-04

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.

Pssm-ID: 276966 [Multi-domain] Cd Length: 48 Bit Score: 39.99 E-value: 2.62e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 74761342  914 KKKCEKGGRLLCCESCPASFHPECLSIE----MPEGCWNCNDC 952
Cdd:cd15489    6 GKGGDLGGELLQCDGCGKWFHADCLGPPlssfVPNGKWICPVC 48

PWWP_ZCWPW1

cd20145

PWWP domain found in zinc finger CW-type PWWP domain protein 1 (ZCWPW1) and similar proteins; ...

963-1047

2.72e-04

Pssm-ID: 438973 Cd Length: 115 Bit Score: 41.77 E-value: 2.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  963 IVWVKLGNYRWWPA--EICnprsvplniqglkHDLGDFpvFFFGSHDYY----------------WVHQGRVFPYvEGDK 1024
Cdd:cd20145   11 LVWAKMPGYPWWPAmvEDD-------------PDTEEF--FWLDEESDIptkyhvtffdkpvsraWVRASSIKPF-TDNS 74

                         90       100
                 ....*....|....*....|...
gi 74761342 1025 SFAEGQTSINKTFKKALEEAAKR 1047
Cdd:cd20145   75 NEPNLTKKKGKKYKKRLNEAVEM 97

PHD_TIF1_like

cd15541

PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar ...

917-952

2.78e-04

Pssm-ID: 277016 [Multi-domain] Cd Length: 43 Bit Score: 39.63 E-value: 2.78e-04

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCESCPASFHPEC---LSIEMPEGCWNCNDC 952
Cdd:cd15541    5 CQNGGELLCCDKCPRVFHLDChipPIPEFPSGEWSCSLC 43

PWWP_HDGFL3

cd20150

PWWP domain found in Hepatoma-derived growth factor-related protein 3 (HDGFL3); HDGFL3, also ...

955-1043

3.10e-04

PWWP domain found in Hepatoma-derived growth factor-related protein 3 (HDGFL3); HDGFL3, also called HDGF-related protein 3 (HRP-3), is the only hepatoma-derived growth factor (HDGF)-related protein (HRP) family member whose expression is almost restricted to the nervous tissue. It enhances DNA synthesis and may play a role in cell proliferation. It contains a PWWP domain, which is necessary for DNA binding.

Pssm-ID: 438978 [Multi-domain] Cd Length: 93 Bit Score: 41.20 E-value: 3.10e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  955 GKKLHYK--QIVWVKLGNYRWWPAEICNprsvpLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFaeGQTS 1032
Cdd:cd20150    1 PRPREYKagDLVFAKMKGYPHWPARIDE-----LPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYKEYKDKF--GKSN 73

                         90
                 ....*....|.
gi 74761342 1033 INKTFKKALEE 1043
Cdd:cd20150   74 KRKGFNEGLWE 84

PHD

PHD zinc finger; The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in ...

703-745

3.19e-04

Pssm-ID: 214584 [Multi-domain] Cd Length: 47 Bit Score: 39.89 E-value: 3.19e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 74761342     703 VCQICESSGDS--LIPCEGeCCKHFHLECLGLA---SLPDSKFICMEC 745
Cdd:smart00249    1 YCSVCGKPDDGgeLLQCDG-CDRWYHQTCLGPPlleEEPDGKWYCPKC 47

SET_SMYD4

cd10536

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...

1221-1261

3.47e-04

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.

Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 43.44 E-value: 3.47e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 74761342 1221 FMNHSCNPNCETqkwTVNGDVrVGLFALCDIPAGMELTFNY 1261
Cdd:cd10536  153 LLNHSCDPNTIR---SFYGNT-IVVRATRPIKKGEEITICY 189

PHD5_NSD

cd15568

PHD finger 5 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

703-743

3.81e-04

Pssm-ID: 277043 [Multi-domain] Cd Length: 43 Bit Score: 39.23 E-value: 3.81e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 74761342  703 VCQICESSGDsLIPCEGECC-KHFHLECLGLASLPDSKFICM 743
Cdd:cd15568    1 ECFRCGDGGD-LVLCDFKGCpKVYHLSCLGLEKPPGGKWICP 41

PHD

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...

703-746

4.80e-04

Pssm-ID: 425785 [Multi-domain] Cd Length: 51 Bit Score: 39.40 E-value: 4.80e-04

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 74761342    703 VCQICESSGDS--LIPCEGeCCKHFHLECLGL----ASLPDSKFICMECK 746
Cdd:pfam00628    1 YCAVCGKSDDGgeLVQCDG-CDDWFHLACLGPpldpAEIPSGEWLCPECK 49

PHD_TIF1gamma

cd15624

PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma); TIF1gamma, also ...

917-953

5.90e-04

PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma); TIF1gamma, also termed tripartite motif-containing 33 (trim33), or ectodermin, or RFG7, or PTC7, is an E3-ubiquitin ligase that functions as a regulator of transforming growth factor beta (TGFbeta) signaling; it inhibits the Smad4-mediated TGFbeta response by interaction with Smad2/3 or ubiquitylation of Smad4. Moreover, TIF1gamma is an important regulator of transcription during hematopoiesis, as well as a key factor of tumorigenesis. Like other TIF1 family members, TIF1gamma also contains an intrinsic transcriptional silencing function. It can control erythroid cell fate by regulating transcription elongation. It can bind to the anaphase-promoting complex/cyclosome (APC/C) and promotes mitosis. TIF1gamma contains an N-terminal RBCC (RING finger, B-box zinc-fingers, coiled-coil), a plant homeodomain (PHD) finger, followed by a bromodomain in the C-terminal region.

Pssm-ID: 277094 Cd Length: 46 Bit Score: 38.88 E-value: 5.90e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 74761342  917 CEKGGRLLCCESCPASFHPEC---LSIEMPEGCWNCNDCK 953
Cdd:cd15624    5 CQNGGDLLCCEKCPKVFHLTChvpTLLSFPSGDWICTFCR 44

PHD_PRKCBP1

cd15538

PHD finger found in protein kinase C-binding protein 1 (PRKCBP1); PRKCBP1, also termed ...

916-952

6.19e-04

Pssm-ID: 277013 Cd Length: 41 Bit Score: 38.85 E-value: 6.19e-04

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 74761342  916 KCEKGGRLLCCESCPASFHPECL-SIEMPEGCWNCNDC 952
Cdd:cd15538    4 RCHKEGQVLCCSLCPRVYHKKCLkLTSEPDEDWVCPEC 41

PHD1_Rco1

cd15535

PHD finger 1 found in Saccharomyces cerevisiae transcriptional regulatory protein Rco1 and ...

1323-1370

6.64e-04

Pssm-ID: 277010 [Multi-domain] Cd Length: 45 Bit Score: 38.94 E-value: 6.64e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 74761342 1323 YCFQCGDGGELVMCDkkDCPKAYHLLCLNLTQPPYGKWECPWHqCDEC 1370
Cdd:cd15535    1 FCSACGGYGSFLCCD--GCPRSFHFSCLDPPLEEDNLPDDEWF-CNEC 45

PHD1_NSD1_2

cd15648

PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2; ...

917-953

6.73e-04

Pssm-ID: 277118 Cd Length: 43 Bit Score: 38.61 E-value: 6.73e-04

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCE-SCPASFHPECLSI-EMPEGCWNCNDCK 953
Cdd:cd15648    5 CEKPGELLLCEgQCCGAFHLDCIGLsEMPSGKFICDECI 43

PHD_SF

cd15489

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...

1323-1365

8.21e-04

Pssm-ID: 276966 [Multi-domain] Cd Length: 48 Bit Score: 38.45 E-value: 8.21e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 74761342 1323 YCFQCGDGG----ELVMCDKkdCPKAYHLLCLNLTQP---PYGKWECPWH 1365
Cdd:cd15489    1 SCIVCGKGGdlggELLQCDG--CGKWFHADCLGPPLSsfvPNGKWICPVC 48

PWWP_NSD1_rpt2

cd20164

second PWWP domain found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) ...

272-330

9.31e-04

Pssm-ID: 438992 Cd Length: 96 Bit Score: 39.86 E-value: 9.31e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 74761342  272 DLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQpERAWVHEKRVREY 330
Cdd:cd20164    4 EVVWVKVGRYRWWPAEVCHPKSIPTNIQKMKHDIGEFPVLFFGSN-DYLWTHQARVFPY 61

PHD_TIF1alpha

cd15622

PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha); TIF1-alpha, also ...

917-952

1.07e-03

PHD finger found in transcription intermediary factor 1-alpha (TIF1-alpha); TIF1-alpha, also termed tripartite motif-containing protein 24 (TRIM24), or E3 ubiquitin-protein ligase TRIM24, or RING finger protein 82, belongs to the TRIM/RBCC protein family. It interacts specifically and in a ligand-dependent manner with the ligand binding domain (LBD) of several nuclear receptors (NRs), including retinoid X (RXR), retinoic acid (RAR), vitamin D3 (VDR), estrogen (ER), and progesterone (PR) receptors. It also associates with heterochromatin-associated factors HP1alpha, MOD1 (HP1beta) and MOD2 (HP1gamma), as well as vertebrate Kruppel-type (C2H2) zinc finger proteins that contain transcriptional silencing domain KRAB. TIF1-alpha is a ligand-dependent co-repressor of retinoic acid receptor (RAR) that interacts with multiple nuclear receptors in vitro via an LXXLL motif, and further acts as a gatekeeper of liver carcinogenesis. It also functions as an E3-ubiquitin ligase targeting p53 and is broadly associated with chromatin silencing. Moreover, it is a chromatin regulator that recognizes specific, combinatorial histone modifications through its C-terminal plant homeodomain (PHD)-Bromodomain (Bromo) region. In addition, it interacts with chromatin and estrogen receptor to activate estrogen-dependent genes associated with cellular proliferation and tumor development. TIF1-alpha contains an N-terminal RBCC (RING finger, B-box zinc-fingers, coiled-coil), a plant homeodomain (PHD) finger, followed by a bromodomain in the C-terminal region.

Pssm-ID: 277092 Cd Length: 43 Bit Score: 38.12 E-value: 1.07e-03

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCESCPASFHPEC---LSIEMPEGCWNCNDC 952
Cdd:cd15622    5 CQNGGELLCCEKCPKVFHLSChvpTLMNFPSGEWICTFC 43

PWWP_NSD2_rpt2

cd20165

second PWWP domain found in nuclear SET domain-containing protein 2 (NSD2) and similar ...

267-330

1.09e-03

Pssm-ID: 438993 Cd Length: 96 Bit Score: 39.94 E-value: 1.09e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74761342  267 KFQvgDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQpERAWVHEKRVREY 330
Cdd:cd20165    1 RFQ--DIIWVKLGNYRWWPAEVCHPKNVPPNIQKMKHEIGEFPVFFFGSK-DYYWTHQARVFPY 61

PHD_Yng1p_like

cd15587

PHD finger found in yeast orthologs of ING tumor suppressor family; The yeast orthologs of the ...

1323-1363

1.12e-03

PHD finger found in yeast orthologs of ING tumor suppressor family; The yeast orthologs of the plant homeodomain (PHD) finger-containing ING tumor suppressor family consists of chromatin modification-related protein YNG1 (Yng1p), YNG2 (Yng2p), and transcriptional regulatory protein PHO23 (Pho23p). Yng1p, also termed ING1 homolog 1, is one of the components of the NuA3 histone acetyltransferase (HAT) complex. Its PHD finger binding to H3 Trimethylated at K4 (H3K4me3) promotes NuA3 H3 HAT activity at K14 of H3 on chromatin. Yng2p, also termed ESA1-associated factor 4, or ING1 homolog 2, is a subunit of the NuA4 HAT complex. It plays a critical role in intra-S-phase DNA damage response. Pho23p is part of the Rpd3/Sin3 histone deacetylase (HDAC) complex. It is required for the normal function of Rpd3 in the silencing of rDNA, telomeric, and mating-type loci. Yng1p and Pho23p inhibit p53-dependent transcription. In contrast, Yng2p has the opposite effect. All family members contain an N-terminal ING histone-binding domain and a C-terminal PHD finger.

Pssm-ID: 277062 [Multi-domain] Cd Length: 47 Bit Score: 38.16 E-value: 1.12e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 74761342 1323 YCFqCG--DGGELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15587    1 YCY-CRrvSFGEMVACDNPDCKiEWFHFECVGLTETPKGKWYCS 43

PHD1_Lid2p_like

cd15519

PHD finger 1 found in Schizosaccharomyces pombe Lid2 complex component Lid2p and similar ...

1324-1363

1.20e-03

PHD finger 1 found in Schizosaccharomyces pombe Lid2 complex component Lid2p and similar proteins; Lid2p is a trimethyl H3K4 (H3K4me3) demethylase responsible for H3K4 hypomethylation in heterochromatin. It interacts with the histone lysine-9 methyltransferase, Clr4, through the Dos1/Clr8-Rik1 complex, and mediates H3K9 methylation and small RNA production. It also acts cooperatively with the histone modification enzymes Set1 and Lsd1 and plays an essential role in cross-talk between H3K4 and H3K9 methylation in euchromatin. Lid2p contains a JmjC domain, three PHD fingers and a JmjN domain. This model corresponds to the first PHD finger.

Pssm-ID: 276994 [Multi-domain] Cd Length: 46 Bit Score: 38.22 E-value: 1.20e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 74761342 1324 CFQCG---DGGELVMCDkkDCPKAYHLLCLN--LTQPPYGKWECP 1363
Cdd:cd15519    2 CEVCGlddNEGEVLLCD--GCDAEYHTSCLDppLGEIPPGTWFCP 44

PHD_ING2

cd15683

PHD finger found in inhibitor of growth protein 2 (ING2); ING2, also termed inhibitor of ...

1331-1363

1.21e-03

PHD finger found in inhibitor of growth protein 2 (ING2); ING2, also termed inhibitor of growth 1-like protein (ING1Lp), or p32, or p33ING2, is one member of the inhibitor of growth (ING) family of type II tumor suppressors. It is a core component of a multi-factor chromatin-modifying complex containing the transcriptional co-repressor SIN3A and histone deacetylase 1 (HDAC1). It has been implicated in the control of cell cycle, in genome stability, and in muscle differentiation. ING2 independently interacts with H3K4me3 (Histone H3 trimethylated on lysine 4) and PtdIns(5)P, and modulates crosstalk between lysine methylation and lysine acetylation on histone proteins through association with chromatin in the presence of DNA damage. It collaborates with SnoN to mediate transforming growth factor (TGF)-beta-induced Smad-dependent transcription and cellular responses. It is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. It also acts as a cofactor of p300 for p53 acetylation and plays a positive regulatory role during p53-mediated replicative senescence. ING2 contains an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.

Pssm-ID: 277153 [Multi-domain] Cd Length: 49 Bit Score: 38.08 E-value: 1.21e-03

                         10        20        30
                 ....*....|....*....|....*....|....
gi 74761342 1331 GELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15683   11 GEMIGCDNEQCPiEWFHFSCVGLTYKPKGKWYCP 44

PHD_SF

cd15489

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...

703-745

1.56e-03

Pssm-ID: 276966 [Multi-domain] Cd Length: 48 Bit Score: 37.68 E-value: 1.56e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 74761342  703 VCQICESSGDSLIPCEGeCCKHFHLECLGLA---SLPDSKFICMEC 745
Cdd:cd15489    4 VCGKGGDLGGELLQCDG-CGKWFHADCLGPPlssFVPNGKWICPVC 48

PHD_ING1_2

cd15584

PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2); ING1 is an epigenetic ...

1331-1363

1.58e-03

PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2); ING1 is an epigenetic regulator and a type II tumor suppressor that impacts cell growth, aging, apoptosis, and DNA repair, by affecting chromatin conformation and gene expression. It acts as a reader of the active chromatin mark, the trimethylation of histone H3 lysine 4 (H3K4me3). It binds and directs Growth arrest and DNA damage inducible protein 45 a (Gadd45a) to target sites, thus linking the histone code with DNA demethylation. It interacts with the proliferating cell nuclear antigen (PCNA) via the PCNA-interacting protein (PIP) domain in a UV-inducible manner. It also interacts with a PCNA-interacting protein, p15 (PAF). Moreover, ING1 associates with members of the 14-3-3 family, which is necessary for cytoplasmic relocalization. Endogenous ING1 protein specifically interacts with the pro-apoptotic BCL2 family member BAX and colocalizes with BAX in a UV-inducible manner. It stabilizes the p53 tumor suppressor by inhibiting polyubiquitination of multi-monoubiquitinated forms via interaction with and colocalization of the herpesvirus-associated ubiquitin-specific protease (HAUSP)-deubiquitinase with p53. It is also involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells. In addition, tyrosine kinase Src can bind and phosphorylate ING1 and further regulates its activity. ING2, also termed inhibitor of growth 1-like protein (ING1Lp), or p32, or p33ING2, belongs to the inhibitor of growth (ING) family of type II tumor suppressors. It is a core component of a multi-factor chromatin-modifying complex containing the transcriptional co-repressor SIN3A and histone deacetylase 1 (HDAC1). It has been implicated in the control of cell cycle, in genome stability, and in muscle differentiation. ING2 independently interacts with H3K4me3 (Histone H3 trimethylated on lysine 4) and PtdIns(5)P, and modulates crosstalk between lysine methylation and lysine acetylation on histone proteins through association with chromatin in the presence of DNA damage. It collaborates with SnoN to mediate transforming growth factor (TGF)-beta-induced Smad-dependent transcription and cellular responses. It is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. It also acts as a cofactor of p300 for p53 acetylation and plays a positive regulatory role during p53-mediated replicative senescence. Both ING1 and ING2 contain an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.

Pssm-ID: 277059 [Multi-domain] Cd Length: 45 Bit Score: 37.81 E-value: 1.58e-03

                         10        20        30
                 ....*....|....*....|....*....|....
gi 74761342 1331 GELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15584   10 GEMIGCDNDECPiEWFHFSCVGLTHKPKGKWYCP 43

SET_KMT5C

cd19185

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...

1152-1275

1.60e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.

Pssm-ID: 380962 Cd Length: 142 Bit Score: 40.41 E-value: 1.60e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342 1152 TERRGWGLRTKRSIKKGEFVNEYVG---ELIDEEECRLRikrAHENSVTNFYMlTVTKDRIIDAGPkgnySRFMNHSCNP 1228
Cdd:cd19185   15 METNGAKIVSTRAWKKNEKLELLVGciaELREEDEGLLR---AGENDFSIMYS-TRKRSAQLWLGP----AAFINHDCKP 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 74761342 1229 NCetqKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHC 1275
Cdd:cd19185   87 NC---KFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCEC 130

TNG2

COG5034

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

602-746

1.83e-03

Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics];

Pssm-ID: 227367 [Multi-domain] Cd Length: 271 Bit Score: 41.85 E-value: 1.83e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  602 EQVETVPQATvkTGLQKGASEISDSCKPLKKRSRASTDVEMTSSA----------YRDTSDSDSRGLSDLQVgfgkqvdS 671
Cdd:COG5034  117 ARIENCHDAV--SRLERNSYSSAARRSSGEHRSAASSQGSRHTKLkkrknihnlkRRSPELSSKREVSFTLE-------S 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74761342  672 PSATADADVSDVQSMDSSLSRRG---TGMSKKDTVCQICES-SGDSLIPCEGECCKH--FHLECLGLASLPDSKFICMEC 745
Cdd:COG5034  188 PSVPDTATRVKEGNNGGSTKSRGvssEDNSEGEELYCFCQQvSYGQMVACDNANCKRewFHLECVGLKEPPKGKWYCPEC 267


                 .
gi 74761342  746 K 746
Cdd:COG5034  268 K 268

PHD4_NSD1

cd15656

PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1); NSD1, ...

1323-1362

2.29e-03

Pssm-ID: 277126 Cd Length: 40 Bit Score: 37.30 E-value: 2.29e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 74761342 1323 YCFQCGDGGELVMCDKkdCPKAYHLLCLNLTQPPyGKWEC 1362
Cdd:cd15656    1 WCFVCSEGGSLLCCES--CPAAFHRECLNIDMPE-GSWYC 37

PHD_ING1

cd15682

PHD finger found in inhibitor of growth protein 1 (ING1); ING1 is an epigenetic regulator and ...

1331-1363

2.49e-03

PHD finger found in inhibitor of growth protein 1 (ING1); ING1 is an epigenetic regulator and a type II tumor suppressor that impacts cell growth, aging, apoptosis, and DNA repair, by affecting chromatin conformation and gene expression. It acts as a reader of the active chromatin mark, the trimethylation of histone H3 lysine 4 (H3K4me3). It binds and directs Growth arrest and DNA damage inducible protein 45 a (Gadd45a) to target sites, thus linking the histone code with DNA demethylation. It interacts with the proliferating cell nuclear antigen (PCNA) via the PCNA-interacting protein (PIP) domain in a UV-inducible manner. It also interacts with a PCNA-interacting protein, p15 (PAF). Moreover, ING1 associates with members of the 14-3-3 family, which is necessary for the cytoplasmic relocalization. Endogenous ING1 protein specifically interacts with the pro-apoptotic BCL2 family member BAX and colocalizes with BAX in a UV-inducible manner. It stabilizes the p53 tumor suppressor by inhibiting polyubiquitination of multi-monoubiquitinated forms via interaction with and colocalization of the herpesvirus-associated ubiquitin-specific protease (HAUSP)-deubiquitinase with p53. It is also involved in trichostatin A-induced apoptosis and caspase 3 signaling in p53-deficient glioblastoma cells. In addition, tyrosine kinase Src can bind phosphorylate ING1 and further regulates its activity. ING1 contains an N-terminal ING domain and a C-terminal plant homeodomain (PHD) finger.

Pssm-ID: 277152 [Multi-domain] Cd Length: 49 Bit Score: 37.30 E-value: 2.49e-03

                         10        20        30
                 ....*....|....*....|....*....|....
gi 74761342 1331 GELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15682   11 GEMIGCDNDECPiEWFHFSCVGLNHKPKGKWYCP 44

PHD_ING4

cd15684

PHD finger found in inhibitor of growth protein 4 (ING4); ING4, also termed p29ING4, is one ...

1331-1363

2.62e-03

PHD finger found in inhibitor of growth protein 4 (ING4); ING4, also termed p29ING4, is one member of the inhibitor of growth (ING) family of type II tumor suppressors. It acts as an E3 ubiquitin ligase to induce ubiquitination of the p65 subunit of NF-kappaB and inhibit the transactivation of NF-kappaB target genes. It also induces apoptosis through a p53 dependent pathway, including increasing p53 acetylation, inhibiting Mdm2-mediated degradation of p53 and enhancing the expression of p53 responsive genes both at the transcriptional and post-translational levels. Moreover, ING4 can inhibit the translation of proto-oncogene MYC by interacting with AUF1. It also regulates other transcription factors, such as hypoxia-inducible factor (HIF). In addition, ING4 associates with histone acetyltransferase (HAT) complexes containing MOZ (monocytic leukemia zinc finger protein)/MORF (MOZ-related factor) and HBO1, and further directs the MOZ/MORF and HBO1 complexes to chromatin. ING4 contains an N-terminal ING histone-binding domain and a C-terminal plant homeodomain (PHD) finger.

Pssm-ID: 277154 [Multi-domain] Cd Length: 48 Bit Score: 37.36 E-value: 2.62e-03

                         10        20        30
                 ....*....|....*....|....*....|....
gi 74761342 1331 GELVMCDKKDCP-KAYHLLCLNLTQPPYGKWECP 1363
Cdd:cd15684   11 GEMIGCDNPDCSiEWFHFACVGLTTKPRGKWFCP 44

PWWP_DNMT3

cd05835

PWWP domain found in the DNA (cytosine-5)-methyltransferase 3 (DNMT3) family; The DNMT3 family ...

269-288

2.70e-03

Pssm-ID: 438960 [Multi-domain] Cd Length: 89 Bit Score: 38.39 E-value: 2.70e-03

                         10        20
                 ....*....|....*....|
gi 74761342  269 QVGDLVWSKVGTYPWWPCMV 288
Cdd:cd05835    1 KIGDLVWAKLKGSPWWPGIV 20

PHD_PHF21A

cd15523

PHD finger found in PHD finger protein 21A (PHF21A); PHF21A (also termed BHC80a or BRAF35-HDAC ...

917-952

2.85e-03

Pssm-ID: 276998 [Multi-domain] Cd Length: 43 Bit Score: 36.99 E-value: 2.85e-03

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCESCPASFHPECLS---IEMPEGCWNCNDC 952
Cdd:cd15523    5 CRKSGELLMCDTCSLVYHLDCLDpplKTIPKGMWICPKC 43

PWWP_HULK

cd20147

PWWP domain found in Arabidopsis thaliana protein HUA2-LIKE (HULK) family; The HULK family ...

271-347

2.92e-03

PWWP domain found in Arabidopsis thaliana protein HUA2-LIKE (HULK) family; The HULK family includes HUA2-like proteins 1-3 (HULK1-3), which are probable transcription factors that act with partial redundancy with each other. They may play diverse and essential roles in the control of plant development, physiology and flowering time. The PWWP domain specifically recognizes DNA and histone methylated lysines.

Pssm-ID: 438975 [Multi-domain] Cd Length: 92 Bit Score: 38.24 E-value: 2.92e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74761342  271 GDLVWSKVGTYPWWPCMVSsdpqlEVHTKINTRGAREYHVQFFSNQpERAWVHEKRVREYKGHKQyEELLAEATKQA 347
Cdd:cd20147    1 GDLVLAKVKGFPAWPAQVS-----EPEDWGSAPDPKKVFVHFFGTQ-QIGFCNPGELSEFTEEIK-QSLLARTLKKK 70

PHD2_PHF14

cd15562

PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins; PHF14 is a novel ...

1324-1370

3.01e-03

PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins; PHF14 is a novel nuclear transcription factor that controls the proliferation of mesenchymal cells by directly repressing platelet-derived growth factor receptor-alpha (PDGFRalpha) expression. It also acts as an epigenetic regulator and plays an important role in the development of multiple organs in mammals. PHF14 contains three canonical plant homeodomain (PHD) fingers and a non-canonical extended PHD (ePHD) finger, Cys2HisCys5HisCys2His. It can interact with histones through its PHD fingers. The model corresponds to the second PHD finger.

Pssm-ID: 277037 Cd Length: 50 Bit Score: 37.00 E-value: 3.01e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 74761342 1324 CFQCGDGGELVMCDKkdCPKAYHLLCLN--LTQPPYGKWECPWhQCDEC 1370
Cdd:cd15562    5 CKKSNDQHLLALCDT--CKLYYHLGCLDppLTRMPKKTKNSGW-QCSEC 50

PHD_TIF1delta

cd15625

PHD finger found in transcriptional intermediary factor 1 delta (TIF1delta); TIF1delta, also ...

917-953

3.17e-03

Pssm-ID: 277095 [Multi-domain] Cd Length: 49 Bit Score: 36.86 E-value: 3.17e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 74761342  917 CEKGGRLLCCESCPASFHPEC---LSIEMPEGCWNCNDCK 953
Cdd:cd15625    8 CLNGGELLCCDRCPKVFHLSChvpALLSFPVGEWVCTLCR 47

PHD_BS69

cd15537

PHD finger found in protein BS69; Protein BS69, also termed zinc finger MYND domain-containing ...

1323-1364

3.25e-03

PHD finger found in protein BS69; Protein BS69, also termed zinc finger MYND domain-containing protein 11 (ZMYND11 or ZMY11), is a ubiquitously expressed nuclear protein acting as a transcriptional co-repressor in association with various transcription factors. It was originally identified as an adenovirus 5 E1A-binding protein that inhibits E1A transactivation, as well as c-Myb transcription. It also mediates repression, at least in part, through interaction with the co-repressor N-CoR. Moreover, it interacts with Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule-1 (TICAM-1, also named TRIF) to facilitate NF-kappaB activation and type I IFN induction. It associates with PIAS1, a SUMO E3 enzyme, and Ubc9, a SUMO E2 enzyme, and plays an inhibitory role in muscle and neuronal differentiation. Moreover, BS69 regulates Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1)/C-terminal activation region 2 (CTAR2)-mediated NF-kappaB activation by interfering with the complex formation between TNFR-associated death domain protein (TRADD) and LMP1/CTAR2. It also cooperates with tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) in the regulation of EBV-derived LMP1/CTAR1-induced NF-kappaB activation. Furthermore, BS69 is involved in the p53-p21Cip1-mediated senescence pathway. BS69 contains a plant homeodomain (PHD) finger, a bromodomain, a proline-tryptophan-tryptophan-proline (PWWP) domain, and a Myeloid translocation protein 8, Nervy and DEAF-1 (MYND) domain.

Pssm-ID: 277012 Cd Length: 43 Bit Score: 36.94 E-value: 3.25e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 74761342 1323 YCFQCGDGGELVMCDkkDCPKAYHLLCLNLTQPPY--GKWECPW 1364
Cdd:cd15537    1 YCFECHAPGEVLPCS--GCFRVYHSDCLSEDFRPDstSHWTCPV 42

PHD_RSF1

cd15543

PHD finger found in Remodeling and spacing factor 1 (Rsf-1); Rsf-1, also termed HBV ...

1324-1363

3.28e-03

PHD finger found in Remodeling and spacing factor 1 (Rsf-1); Rsf-1, also termed HBV pX-associated protein 8, or Hepatitis B virus X-associated protein alpha (HBxAPalpha), or p325 subunit of RSF chromatin-remodeling complex, is a novel nuclear protein with histone chaperon function. It is a subunit of an ISWI chromatin remodeling complex, remodeling and spacing factor (RSF), and plays a role in mediating ATPase-dependent chromatin remodeling and conferring tumor aggressiveness in common carcinomas. As an ataxia-telangiectasia mutated (ATM)-dependent chromatin remodeler, Rsf-1 facilitates DNA damage checkpoints and homologous recombination repair. It regulates the mitotic spindle checkpoint and chromosome instability through the association with serine/threonine kinase BubR1 (BubR1) and Hepatitis B virus (HBV) X protein (HBx) in the chromatin fraction during mitosis. It also interacts with cyclin E1 and promotes tumor development. Rsf-1 contains a plant homeodomain (PHD) finger.

Pssm-ID: 277018 [Multi-domain] Cd Length: 46 Bit Score: 36.86 E-value: 3.28e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 74761342 1324 CFQCGDGGELVMCDKkdCPKAYHLLCLN--LTQPPYGKWECP 1363
Cdd:cd15543    5 CGLSDHPEWILLCDR--CDAGYHTACLRppLMIIPDGNWFCP 44

PHD_PHF21B

cd15524

PHD finger found in PHD finger protein 21B (PHF21B); PHF21B is a plant homeodomain (PHD) ...

917-952

3.52e-03

Pssm-ID: 276999 [Multi-domain] Cd Length: 43 Bit Score: 36.79 E-value: 3.52e-03

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 74761342  917 CEKGGRLLCCESCPASFHPECLSIEM---PEGCWNCNDC 952
Cdd:cd15524    5 CKRGGNLQPCGTCPRAYHLDCLDPPLktaPKGVWVCPKC 43

PWWP_AtATX1-like

cd20142

PWWP domain found in Arabidopsis thaliana histone-lysine N-methyltransferase trithorax-like ...

269-327

3.85e-03

Pssm-ID: 438970 [Multi-domain] Cd Length: 97 Bit Score: 38.10 E-value: 3.85e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74761342  269 QVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTR--GAREYHVQFFSNQpERAWVHEKRV 327
Cdd:cd20142    1 SPGDVVWAKVKGYPMWPALVIDEEHAERCGLEANRpgKKGTVPVQFFGTY-EVARLNPKKV 60

PHD5_NSD

cd15568

PHD finger 5 found in nuclear receptor-binding SET domain-containing (NSD) proteins; The ...

917-949

3.85e-03

Pssm-ID: 277043 [Multi-domain] Cd Length: 43 Bit Score: 36.54 E-value: 3.85e-03

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 74761342  917 CEKGGRLLCC--ESCPASFHPECLSIEMPE-GCWNC 949
Cdd:cd15568    5 CGDGGDLVLCdfKGCPKVYHLSCLGLEKPPgGKWIC 40

PHD4_NSD3