NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755546230|ref|XP_011242941|]
View 

LHFPL tetraspan subfamily member 2 protein isoform X1 [Mus musculus]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 229584)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Gene Ontology:  GO:0016020
PubMed:  19706201

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PMP22_Claudin super family cl21598
PMP-22/EMP/MP20/Claudin family;
9-198 4.21e-54

PMP-22/EMP/MP20/Claudin family;


The actual alignment was detected with superfamily member pfam10242:

Pssm-ID: 451326  Cd Length: 180  Bit Score: 171.36  E-value: 4.21e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546230    9 RSMLWTLLSIVVAFAELVAFMSADWLIGKAKTRsgsgdeqagmnsEPHYLGIL--CIRtpaMQQvsRDTLCGTYAKSFGE 86
Cdd:pfam10242   1 VGVLWALLTICFAVLSVVAFVQPYWLGGSVSSP------------KAGSFGLYsrCKG---MDQ--MELTCGGYALDFLA 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546230   87 IASGFWQATAIFLAVGIFILCVVALVSVFTMCVQSIMRKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAID-CGRYA 165
Cdd:pfam10242  64 IPSSAWQAAMFFVGLGTFLLLSIACLSLFTCCRQSIISKSVFKICGWLQLVAGLCLMLGCLLYPLGWDSPEVRRlCGPES 143
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 755546230  166 SPYKPGDCSLGWAFYTA----TGGTVLTFICAVFSAQ 198
Cdd:pfam10242 144 GPYSLGLCSIGWAYYLAiigiLDALLLTFLAFVLSLR 180
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
9-198 4.21e-54

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.


Pssm-ID: 431166  Cd Length: 180  Bit Score: 171.36  E-value: 4.21e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546230    9 RSMLWTLLSIVVAFAELVAFMSADWLIGKAKTRsgsgdeqagmnsEPHYLGIL--CIRtpaMQQvsRDTLCGTYAKSFGE 86
Cdd:pfam10242   1 VGVLWALLTICFAVLSVVAFVQPYWLGGSVSSP------------KAGSFGLYsrCKG---MDQ--MELTCGGYALDFLA 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546230   87 IASGFWQATAIFLAVGIFILCVVALVSVFTMCVQSIMRKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAID-CGRYA 165
Cdd:pfam10242  64 IPSSAWQAAMFFVGLGTFLLLSIACLSLFTCCRQSIISKSVFKICGWLQLVAGLCLMLGCLLYPLGWDSPEVRRlCGPES 143
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 755546230  166 SPYKPGDCSLGWAFYTA----TGGTVLTFICAVFSAQ 198
Cdd:pfam10242 144 GPYSLGLCSIGWAYYLAiigiLDALLLTFLAFVLSLR 180
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
9-198 4.21e-54

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.


Pssm-ID: 431166  Cd Length: 180  Bit Score: 171.36  E-value: 4.21e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546230    9 RSMLWTLLSIVVAFAELVAFMSADWLIGKAKTRsgsgdeqagmnsEPHYLGIL--CIRtpaMQQvsRDTLCGTYAKSFGE 86
Cdd:pfam10242   1 VGVLWALLTICFAVLSVVAFVQPYWLGGSVSSP------------KAGSFGLYsrCKG---MDQ--MELTCGGYALDFLA 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755546230   87 IASGFWQATAIFLAVGIFILCVVALVSVFTMCVQSIMRKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAID-CGRYA 165
Cdd:pfam10242  64 IPSSAWQAAMFFVGLGTFLLLSIACLSLFTCCRQSIISKSVFKICGWLQLVAGLCLMLGCLLYPLGWDSPEVRRlCGPES 143
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 755546230  166 SPYKPGDCSLGWAFYTA----TGGTVLTFICAVFSAQ 198
Cdd:pfam10242 144 GPYSLGLCSIGWAYYLAiigiLDALLLTFLAFVLSLR 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH