Dos2-interacting transcription regulator of RNA-Pol-II; This domain, along with the C-terminal ...
54-312
1.00e-109
Dos2-interacting transcription regulator of RNA-Pol-II; This domain, along with the C-terminal part, pfam12460, is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly.
:
Pssm-ID: 433995 Cd Length: 258 Bit Score: 335.68 E-value: 1.00e-109
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision ...
556-805
3.42e-51
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.
The actual alignment was detected with superfamily member pfam12460:
Pssm-ID: 463594 Cd Length: 426 Bit Score: 185.16 E-value: 3.42e-51
Dos2-interacting transcription regulator of RNA-Pol-II; This domain, along with the C-terminal ...
54-312
1.00e-109
Dos2-interacting transcription regulator of RNA-Pol-II; This domain, along with the C-terminal part, pfam12460, is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly.
Pssm-ID: 433995 Cd Length: 258 Bit Score: 335.68 E-value: 1.00e-109
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision ...
556-805
3.42e-51
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.
Pssm-ID: 463594 Cd Length: 426 Bit Score: 185.16 E-value: 3.42e-51
Dos2-interacting transcription regulator of RNA-Pol-II; This domain, along with the C-terminal ...
54-312
1.00e-109
Dos2-interacting transcription regulator of RNA-Pol-II; This domain, along with the C-terminal part, pfam12460, is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly.
Pssm-ID: 433995 Cd Length: 258 Bit Score: 335.68 E-value: 1.00e-109
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision ...
556-805
3.42e-51
RNAPII transcription regulator C-terminal; MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly. This domain has a HEAT-like repeat structure.
Pssm-ID: 463594 Cd Length: 426 Bit Score: 185.16 E-value: 3.42e-51
M17 aminopeptidase N-terminal domain 2; This domain is found in the N-terminal region of M17 ...
512-599
4.66e-03
M17 aminopeptidase N-terminal domain 2; This domain is found in the N-terminal region of M17 aminopeptidase (pfam00883) present in Homo sapiens and Mus musculus. M17 aminopeptidases are Zn-dependent exopeptidases that catalyze the removal of unsubstituted amino acid residues from the N-terminus of peptides.
Pssm-ID: 408104 Cd Length: 121 Bit Score: 37.76 E-value: 4.66e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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