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Conserved domains on  [gi|756143012]
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Chain A, Integrin beta-4

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10440908)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
5-90 2.40e-23

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.16  E-value: 2.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012   5 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 84
Cdd:pfam00041  1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                 ....*.
gi 756143012  85 EGFGPE 90
Cdd:pfam00041 79 GGEGPP 84
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
5-90 2.40e-23

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.16  E-value: 2.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012   5 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 84
Cdd:pfam00041  1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                 ....*.
gi 756143012  85 EGFGPE 90
Cdd:pfam00041 79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 5-89 1.32e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 1.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012  5 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAfrVDGDSPESRLTVPGLSENVPYKFKVQARTT 84
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                ....*
gi 756143012 85 EGFGP 89
Cdd:cd00063  80 GGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 5-88 4.28e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 4.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012    5 SAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTT 84
Cdd:smart00060  2 SPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                  ....
gi 756143012   85 EGFG 88
Cdd:smart00060 80 AGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
5-86 4.04e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012   5 SAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTT 84
Cdd:COG3401  234 SAPTGLTATADTPGSVTLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA 307


                 ..
gi 756143012  85 EG 86
Cdd:COG3401  308 AG 309
 
Name Accession Description Interval E-value
fn3 pfam00041
Fibronectin type III domain;
5-90 2.40e-23

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.16  E-value: 2.40e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012   5 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDspESRLTVPGLSENVPYKFKVQARTT 84
Cdd:pfam00041  1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGT--TTSVTLTGLKPGTEYEVRVQAVNG 78


                 ....*.
gi 756143012  85 EGFGPE 90
Cdd:pfam00041 79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 5-89 1.32e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 1.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012  5 SAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAfrVDGDSPESRLTVPGLSENVPYKFKVQARTT 84
Cdd:cd00063   2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEV--EVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79


                ....*
gi 756143012 85 EGFGP 89
Cdd:cd00063  80 GGESP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 5-88 4.28e-15

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 4.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012    5 SAPGPLVFTALSPDSLQLSWERPRRPNGDivGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTT 84
Cdd:smart00060  2 SPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                  ....
gi 756143012   85 EGFG 88
Cdd:smart00060 80 AGEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
5-86 4.04e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012   5 SAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVtcemAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTT 84
Cdd:COG3401  234 SAPTGLTATADTPGSVTLSWDPV--TESDATGYRV----YRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDA 307


                 ..
gi 756143012  85 EG 86
Cdd:COG3401  308 AG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
5-99 7.83e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 36.90  E-value: 7.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756143012   5 SAPGPLVFTALSPDSLQLSWERPrrPNGDIVGYLVTcemaQGGGPATAFRVDGDSP-ESRLTVPGLSENVPYKFKVQART 83
Cdd:COG3401  328 AAPSGLTATAVGSSSITLSWTAS--SDADVTGYNVY----RSTSGGGTYTKIAETVtTTSYTDTGLTPGTTYYYKVTAVD 401

                         90
                 ....*....|....*.
gi 756143012  84 TEGFGPEREGIITIES 99
Cdd:COG3401  402 AAGNESAPSEEVSATT 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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