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Conserved domains on  [gi|7657373|ref|NP_055214|]
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tetraspanin-13 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 11992908)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tetraspanin super family cl28961
Tetraspanin family;
55-190 1.68e-06

Tetraspanin family;


The actual alignment was detected with superfamily member pfam00335:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 46.54  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657373     55 FLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQGQL-------LEVGWNNTASARND------ 121
Cdd:pfam00335  54 VIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLsnwlkksLEDGYRDWLDLYSClnsald 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657373    122 -IQRNLNCCGfrsvnpndtclascvksdhscsPCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRY 190
Cdd:pfam00335 134 sLQSEFGCCG----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCL 181
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
55-190 1.68e-06

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 46.54  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657373     55 FLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQGQL-------LEVGWNNTASARND------ 121
Cdd:pfam00335  54 VIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLsnwlkksLEDGYRDWLDLYSClnsald 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657373    122 -IQRNLNCCGfrsvnpndtclascvksdhscsPCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRY 190
Cdd:pfam00335 134 sLQSEFGCCG----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCL 181
 
Name Accession Description Interval E-value
Tetraspanin pfam00335
Tetraspanin family;
55-190 1.68e-06

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 46.54  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657373     55 FLFLIALVGLIGAVKHHQVLLFFYMIILLLVFIVQFSVSCACLALNQEQQGQL-------LEVGWNNTASARND------ 121
Cdd:pfam00335  54 VIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAELAAGILAFVYRDKLSGLLsnwlkksLEDGYRDWLDLYSClnsald 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657373    122 -IQRNLNCCGfrsvnpndtclascvksdhscsPCAPIIGEYAGEVLRFVGGIGLFFSFTEILGVWLTYRY 190
Cdd:pfam00335 134 sLQSEFGCCG----------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCL 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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