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Conserved domains on  [gi|767908531|ref|XP_011507541|]
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leucine-rich repeat-containing protein 71 isoform X8 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
9-120 5.36e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 84.84  E-value: 5.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   9 PALRKVSLEGNPLPEQSYH---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:COG5238  236 KSLTTLDLSNNQIGDEGVIalaEALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIA 311
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767908531  86 IADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:COG5238  312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE 346
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
9-120 5.36e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 84.84  E-value: 5.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   9 PALRKVSLEGNPLPEQSYH---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:COG5238  236 KSLTTLDLSNNQIGDEGVIalaEALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIA 311
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767908531  86 IADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:COG5238  312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE 346
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
9-122 6.68e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.92  E-value: 6.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   9 PALRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:cd00116  165 RDLKELNLANNGIGDAGIRALaegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAA 240
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767908531  86 IADGLR-LNRSLLWLSLAHNRIQDKGALKLAEVLRAFE 122
Cdd:cd00116  241 LASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR_6 pfam13516
Leucine Rich repeat;
65-87 4.45e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.21  E-value: 4.45e-04
                          10        20
                  ....*....|....*....|...
gi 767908531   65 NRTLVSLNLGFNHIGDEGAGYIA 87
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
93-120 9.09e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.09e-04
                           10        20
                   ....*....|....*....|....*...
gi 767908531    93 NRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
9-120 5.36e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 84.84  E-value: 5.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   9 PALRKVSLEGNPLPEQSYH---KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:COG5238  236 KSLTTLDLSNNQIGDEGVIalaEALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIA 311
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767908531  86 IADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:COG5238  312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE 346
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
5-118 2.50e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.97  E-value: 2.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   5 LEISPALRKVSLEGNPLPEQS---YHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDE 81
Cdd:COG5238  288 LQGNTTLTSLDLSVNRIGDEGaiaLAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQE----NTTLHSLDLSDNQIGDE 363
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767908531  82 GAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 118
Cdd:COG5238  364 GAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
4-118 3.47e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 70.20  E-value: 3.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   4 SLEISPALRKVSLEGNPLPEQ---SYHKLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGD 80
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEgaiALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG----NKTLHTLNLAYNGIGA 334
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767908531  81 EGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVL 118
Cdd:COG5238  335 QGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL 372
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
35-119 6.08e-13

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 69.43  E-value: 6.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531  35 TIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKL 114
Cdd:COG5238  209 TVTTLWLKRNPIGDEGAEILAEALKG----NKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIAL 284

                 ....*
gi 767908531 115 AEVLR 119
Cdd:COG5238  285 AKALQ 289
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
9-122 6.68e-13

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.92  E-value: 6.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   9 PALRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGY 85
Cdd:cd00116  165 RDLKELNLANNGIGDAGIRALaegLKANCNLEVLDLNNNGLTDEGASALAETLAS----LKSLEVLNLGDNNLTDAGAAA 240
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767908531  86 IADGLR-LNRSLLWLSLAHNRIQDKGALKLAEVLRAFE 122
Cdd:cd00116  241 LASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
8-121 3.76e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 63.53  E-value: 3.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   8 SPALRKVSLEGNPLPEQSYHKL-MALDSTIA--HLSLRNNNIDDRGAQLLGQALSTLhscNRTLVSLNLGFNHIGDEGAG 84
Cdd:cd00116  192 NCNLEVLDLNNNGLTDEGASALaETLASLKSleVLNLGDNNLTDAGAAALASALLSP---NISLLTLSLSCNDITDDGAK 268
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767908531  85 YIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRAF 121
Cdd:cd00116  269 DLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEP 305
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
3-119 1.61e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.60  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   3 CSLEISPALRKVSLEGNPLPEQSYHKLMAL--DSTIAHLSLRNNNIDDRGAQLLGQAL---------------------- 58
Cdd:cd00116   75 QGLTKGCGLQELDLSDNALGPDGCGVLESLlrSSSLQELKLNNNGLGDRGLRLLAKGLkdlppaleklvlgrnrlegasc 154
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767908531  59 ---STLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 119
Cdd:cd00116  155 ealAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLA 218
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
32-119 3.88e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.88  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531  32 LDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGA 111
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQ----NTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGV 253

                 ....*...
gi 767908531 112 LKLAEVLR 119
Cdd:COG5238  254 IALAEALK 261
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
4-122 1.69e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.87  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531   4 SLEISPALRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGD 80
Cdd:COG5238  315 GLQGNKTLHTLNLAYNGIGAQGAIALakaLQENTTLHSLDLSDNQIGDEGAIALAKYLEG----NTTLRELNLGKNNIGK 390
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767908531  81 EGAGYIADGLRLNRsLLWLSLAHNRIQDKGALKLAEVLRAFE 122
Cdd:COG5238  391 QGAEALIDALQTNR-LHTLILDGNLIGAEAQQRLEQLLERIK 431
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
50-119 3.86e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 3.86e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767908531  50 GAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 119
Cdd:COG5238  164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALK 233
LRR_6 pfam13516
Leucine Rich repeat;
65-87 4.45e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.21  E-value: 4.45e-04
                          10        20
                  ....*....|....*....|...
gi 767908531   65 NRTLVSLNLGFNHIGDEGAGYIA 87
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
93-120 9.09e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.09e-04
                           10        20
                   ....*....|....*....|....*...
gi 767908531    93 NRSLLWLSLAHNRIQDKGALKLAEVLRA 120
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
65-91 4.83e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 4.83e-03
                           10        20
                   ....*....|....*....|....*..
gi 767908531    65 NRTLVSLNLGFNHIGDEGAGYIADGLR 91
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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