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Conserved domains on  [gi|7706469|ref|NP_057354|]
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Krueppel-like factor 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF1_2_4_N super family cl41729
N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel ...
 4-272 9.46e-46

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.


The actual alignment was detected with superfamily member cd21583:

Pssm-ID: 425360 [Multi-domain]  Cd Length: 299  Bit Score: 158.27  E-value: 9.46e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469    4 SEPILPSFSTFASPCRERGLQERWPRAE------------------PESGGTDDDLNSVLDFILSMGLDGLGAEAAPEPP 65
Cdd:cd21583   1 SGTILPSISTFANQKEKCWEDRWKGEEDksslssclldlqngdsclGRKDDEDLDNYLDLDFILANTAGSDSAGAAGGGY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469   66 PPPPPPAFYYPEP------------GAPPPYSaPAGGLVSELLRPELDAPLGPALHGRFLLAPPGRLVKAEPP-EADGGG 132
Cdd:cd21583  81 YGSLPEPAAPYSAsnppgaysvpeqGSPPPPY-SSSLMAELLRDSDSDYGPSNSIQGRFLVSSAFFPRQDDPDsIKVEPS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  133 GYGCAPGLTRGPRGL---KREGApgpaASCMRGPggrpppppdtpplspdGPARLPA----------------------- 186
Cdd:cd21583 160 MDSYGPVMGMVPQSCpkiKQEGN----VSCMMSF----------------EQPRLANspqaagsmtpplspddlmasecq 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  187 PGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDAAAAAAALGlappaaRGLLTPPASPLELLEAKPKRGRRSWPR 266
Cdd:cd21583 220 QQMMCSPSFPQPHHPHYPPPPQPPLQYQSPHQFGLFEDGLPLQPSAQ------RVLLTPPSSPLELLESKPKRGRRSWPR 293


                ....*.
gi 7706469  267 KRTATH 272
Cdd:cd21583 294 KRTATH 299
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-350 2.84e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 2.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  267 KRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCdRAFSRSDH 346
Cdd:COG5048 382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                ....
gi 7706469  347 LALH 350
Cdd:COG5048 461 LSNH 464
 
Name Accession Description Interval E-value
KLF2_N cd21583
N-terminal domain of Kruppel-like factor 2; Kruppel-like Factor 2 (KLF2, also known as ...
 4-272 9.46e-46

N-terminal domain of Kruppel-like factor 2; Kruppel-like Factor 2 (KLF2, also known as Krueppel-like factor 2 or lung Kruppel-like Factor/LKLF) is a protein that, in humans, is encoded by the KLF2 gene on chromosome 19. It has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis. KLF proteins KLF1, KLF2, KLF4, KLF5, KLF6, and KLF7 are transcriptional activators. KLF2 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF2, which is related to the N-terminal domains of KLF1 and KLF4.


Pssm-ID: 409229 [Multi-domain]  Cd Length: 299  Bit Score: 158.27  E-value: 9.46e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469    4 SEPILPSFSTFASPCRERGLQERWPRAE------------------PESGGTDDDLNSVLDFILSMGLDGLGAEAAPEPP 65
Cdd:cd21583   1 SGTILPSISTFANQKEKCWEDRWKGEEDksslssclldlqngdsclGRKDDEDLDNYLDLDFILANTAGSDSAGAAGGGY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469   66 PPPPPPAFYYPEP------------GAPPPYSaPAGGLVSELLRPELDAPLGPALHGRFLLAPPGRLVKAEPP-EADGGG 132
Cdd:cd21583  81 YGSLPEPAAPYSAsnppgaysvpeqGSPPPPY-SSSLMAELLRDSDSDYGPSNSIQGRFLVSSAFFPRQDDPDsIKVEPS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  133 GYGCAPGLTRGPRGL---KREGApgpaASCMRGPggrpppppdtpplspdGPARLPA----------------------- 186
Cdd:cd21583 160 MDSYGPVMGMVPQSCpkiKQEGN----VSCMMSF----------------EQPRLANspqaagsmtpplspddlmasecq 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  187 PGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDAAAAAAALGlappaaRGLLTPPASPLELLEAKPKRGRRSWPR 266
Cdd:cd21583 220 QQMMCSPSFPQPHHPHYPPPPQPPLQYQSPHQFGLFEDGLPLQPSAQ------RVLLTPPSSPLELLESKPKRGRRSWPR 293


                ....*.
gi 7706469  267 KRTATH 272
Cdd:cd21583 294 KRTATH 299
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-350 2.84e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 2.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  267 KRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCdRAFSRSDH 346
Cdd:COG5048 382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                ....
gi 7706469  347 LALH 350
Cdd:COG5048 461 LSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 1.16e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.16e-05
                          10        20
                  ....*....|....*....|....*.
gi 7706469    318 ELTRHYRKHTGHRPFQCHLCDRAFSR 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
332-354 4.06e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 4.06e-03
                           10        20
                   ....*....|....*....|...
gi 7706469     332 FQCHLCDRAFSRSDHLALHMKRH 354
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
KLF2_N cd21583
N-terminal domain of Kruppel-like factor 2; Kruppel-like Factor 2 (KLF2, also known as ...
 4-272 9.46e-46

N-terminal domain of Kruppel-like factor 2; Kruppel-like Factor 2 (KLF2, also known as Krueppel-like factor 2 or lung Kruppel-like Factor/LKLF) is a protein that, in humans, is encoded by the KLF2 gene on chromosome 19. It has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis. KLF proteins KLF1, KLF2, KLF4, KLF5, KLF6, and KLF7 are transcriptional activators. KLF2 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF2, which is related to the N-terminal domains of KLF1 and KLF4.


Pssm-ID: 409229 [Multi-domain]  Cd Length: 299  Bit Score: 158.27  E-value: 9.46e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469    4 SEPILPSFSTFASPCRERGLQERWPRAE------------------PESGGTDDDLNSVLDFILSMGLDGLGAEAAPEPP 65
Cdd:cd21583   1 SGTILPSISTFANQKEKCWEDRWKGEEDksslssclldlqngdsclGRKDDEDLDNYLDLDFILANTAGSDSAGAAGGGY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469   66 PPPPPPAFYYPEP------------GAPPPYSaPAGGLVSELLRPELDAPLGPALHGRFLLAPPGRLVKAEPP-EADGGG 132
Cdd:cd21583  81 YGSLPEPAAPYSAsnppgaysvpeqGSPPPPY-SSSLMAELLRDSDSDYGPSNSIQGRFLVSSAFFPRQDDPDsIKVEPS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  133 GYGCAPGLTRGPRGL---KREGApgpaASCMRGPggrpppppdtpplspdGPARLPA----------------------- 186
Cdd:cd21583 160 MDSYGPVMGMVPQSCpkiKQEGN----VSCMMSF----------------EQPRLANspqaagsmtpplspddlmasecq 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  187 PGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDAAAAAAALGlappaaRGLLTPPASPLELLEAKPKRGRRSWPR 266
Cdd:cd21583 220 QQMMCSPSFPQPHHPHYPPPPQPPLQYQSPHQFGLFEDGLPLQPSAQ------RVLLTPPSSPLELLESKPKRGRRSWPR 293


                ....*.
gi 7706469  267 KRTATH 272
Cdd:cd21583 294 KRTATH 299
KLF1_2_4_N cd21972
N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel ...
 4-272 1.09e-25

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.


Pssm-ID: 409230 [Multi-domain]  Cd Length: 194  Bit Score: 101.99  E-value: 1.09e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469    4 SEPILPSFSTFASPCRERGLQERWPRAEPESGGTDDDLNSVLDFilsmgldglgaeaapeppppppppafYYPEPGAPPP 83
Cdd:cd21972   1 SESSLVSSGPFAKPEDDLSKFLDLEFILSNTVTSDNDNPPPPDP--------------------------AYPPPESPES 54

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469   84 YSAPAGGLVSELLRPELDAPLGPALHGRFLLAppgrlvkaeppeadggggyGCAPGLTRGPRGLKREGAPGPAAscmrgp 163
Cdd:cd21972  55 CSTVYDSDGCHPTPNAYCGPNGPGLPGHFLLA-------------------GNSPNLGPKIKTENQEQACMPVA------ 109

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  164 ggrpppppdtpplspdGPARLPAPGPRASFPPpfggpgfgapgpglhyAPPAPPAFGLFDDAAAAAAALGLAPP------ 237
Cdd:cd21972 110 ----------------GYSGHYGPREPQRVPP----------------APPPPQYAGHFQYHGHFNMFSPPLRAnhpgms 157

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 7706469  238 --AARGLLTPPASPLELLEAKPKRGRRSWPRKRTATH 272
Cdd:cd21972 158 tvMLTPLSTPPLGFLSPEEAKPKRGRRSWARKRTATH 194
KLF4_N cd21582
N-terminal domain of Kruppel-like factor 4; Kruppel-like factor 4 (KLF4; also known as ...
 1-272 1.32e-13

N-terminal domain of Kruppel-like factor 4; Kruppel-like factor 4 (KLF4; also known as Krueppel-like factor 4 or gut-enriched Kruppel-like factor/GKLF) is a protein that, in humans, is encoded by the KLF4 gene. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer, gastric cancer, esophageal squamous cell carcinoma, intestinal cancer, prostate cancer, bladder cancer and lung cancer. It may act as a tumor promoter where increased KLF4 expression has been reported, such as in oral squamous cell carcinoma and in primary breast ductal carcinoma. KLF4 is one of four key factors that are essential for inducing pluripotent stem cells. KLF4 is highly expressed in non-dividing cells and its overexpression induces cell cycle arrest. KLF proteins KLF1, KLF2, KLF4, KLF5, KLF6, and KLF7 are transcriptional activators. KLF4 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF4, which is related to the N-terminal domains of KLF1 and KLF2.


Pssm-ID: 409228 [Multi-domain]  Cd Length: 335  Bit Score: 70.88  E-value: 1.32e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469    1 MALSEPILPSFSTFAS--PCRERGLQE-----RW-------PRAEPESGGTDDDLNSVL---------------DFILSM 51
Cdd:cd21582   4 MALSGTLLPSISTFASgpAVKEKALGQgsannRWreelshlKRPCPPLGGRCYDQDPPLgmrrkeeefndlldyDFILSN 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469   52 GL----DGLGAEAAPEPPPPPPPPAFYYPEPGAPPPYSA------------------PAGGLVSELLRPELD-APLGPA- 107
Cdd:cd21582  84 SLlqqqQQQQQAASTSSSTSSSSSSPYSYQLPSPQGTATsflypipranladindvsPSGGFVAELMRPDLDpAYLQPTs 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  108 LHGRFLL------APPGRLVKAEPPEADGGGGYGCAPGLTRGPRGLKREGAPGPAASC-MRGPGGRPPPPPDTPPLSPDG 180
Cdd:cd21582 164 LHGKFVVkttmdmGDYSQSINVSKSAPMTKSSVAPSSSLPFMCPRIKQENPSTCTISRpMDGHLGGNSQHGFSQRAPLPS 243

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  181 PARLP-APGPRASFPPPFGGPGFGAPGPGLHYAPPAPPAFGLFDDAAAAAAALGLAPPAARGLLTPPASPL-EllEAKPK 258
Cdd:cd21582 244 RTTPSgGPGGGNSSTAESLMSRDHHPSSQVLSHPPLPLPQGYHPSPGYPPFPPPPSQPQQYQELMSPGSCLpE--EPKPK 321

                       330
                ....*....|....
gi 7706469  259 RGRRSWPRKRTATH 272
Cdd:cd21582 322 RGRRSWPRKRTATH 335
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-350 2.84e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 2.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  267 KRTATHTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCdRAFSRSDH 346
Cdd:COG5048 382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                ....
gi 7706469  347 LALH 350
Cdd:COG5048 461 LSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-354 1.26e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 1.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  272 HTCSYagCGKTYTKSSHLKAHLRT--HTGE--KPYHCNWDGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRafSRSDHL 347
Cdd:COG5048 290 IKSKQ--CNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNS--SSKFSP 365


                ....*..
gi 7706469  348 ALHMKRH 354
Cdd:COG5048 366 LLNNEPP 372
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-343 1.16e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.16e-05
                          10        20
                  ....*....|....*....|....*.
gi 7706469    318 ELTRHYRKHTGHRPFQCHLCDRAFSR 343
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-327 1.62e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 1.62e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 7706469  279 CGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKFARSDELTRHYRKHT 327
Cdd:COG5048  39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 332-354 2.45e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 2.45e-05
                          10        20
                  ....*....|....*....|...
gi 7706469    332 FQCHLCDRAFSRSDHLALHMKRH 354
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 8-272 1.66e-04

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 43.11  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469    8 LPSFSTFASPC----RERGLQERWPRAEPESGGT-----------------------DDDL-NSV-LDFILSMGLDGLGA 58
Cdd:cd22056   3 LPSISTFASLQpleeKQPEILCRWSVDAASSEVEfsivqspievpkdddelgkfldeEDILsNFLdLEFILSSSNGSSSG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469   59 EAAPEP---------------PPPPPPPAFYYPEPGAPPPYSAPAGGLVSELLRPELDAPLGPALHGRFLLAPPGRLVKA 123
Cdd:cd22056  83 PSQQQQcayplpespescstgSDSDGSDAPQPYHGSAGFTSSSPVHSLMAELLTPEMNYPGESSPDSAGKARDGREYTEL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  124 EPPEADGGGGYGCAPGLTRGPRgLKREgapGPAASCMRGPGGRPPPPPDTPPLspdgPARLPAPGPRASFPPPFGGPGFG 203
Cdd:cd22056 163 RALPTAPPAHQPATSPPPLGYK-IKTE---PVEQSCMMAAGGGGFMGQQKPKH----QMHSVHPQAFTHHQAAGPGALQG 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  204 APGPGL-----------------------------HYAPPAPPAF----GLFDDAAAAAAALGLAppaarGLLTPPASP- 249
Cdd:cd22056 235 RGGRGGpdchllhsshhhhhhhhlqyqymnapyppHYAHQGAPQFhgqySVFREPMRVHHQGHPG-----SMLTPPSSPp 309

                       330       340       350
                ....*....|....*....|....*....|
gi 7706469  250 -LELLEA------KPKRGRRSWPRKRTATH 272
Cdd:cd22056 310 lLEFYAQdepediKPKRGRRSWARKRTATH 339
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-355 3.81e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706469  271 THTCSYAGCGKTYTKSSHLKAHLRTHTGEKPYHCNWDGCGWKF-----ARSDELTRHYRKHTGHRPFQC--HLCDRAFSR 343
Cdd:COG5048 321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKR 400

                        90
                ....*....|..
gi 7706469  344 SDHLALHMKRHM 355
Cdd:COG5048 401 DSNLSLHIITHL 412
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 272-296 4.92e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 4.92e-04
                          10        20
                  ....*....|....*....|....*
gi 7706469    272 HTCSYagCGKTYTKSSHLKAHLRTH 296
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-315 2.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.21e-03
                          10        20
                  ....*....|....*....|....*...
gi 7706469    288 HLKAHLRTHTGEKPYHCnwDGCGWKFAR 315
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
332-354 4.06e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 4.06e-03
                           10        20
                   ....*....|....*....|...
gi 7706469     332 FQCHLCDRAFSRSDHLALHMKRH 354
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 302-326 5.55e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 5.55e-03
                          10        20
                  ....*....|....*....|....*
gi 7706469    302 YHCNwdGCGWKFARSDELTRHYRKH 326
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 332-354 7.57e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 33.77  E-value: 7.57e-03
                          10        20
                  ....*....|....*....|...
gi 7706469    332 FQCHLCDRAFSRSDHLALHMKRH 354
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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