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Conserved domains on  [gi|77169158|gb|ABA63516|]
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gyrase subunit A, partial [Clostridium perfringens]

Protein Classification

DNA gyrase subunit A family protein( domain architecture ID 1000081)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state; may be partial

CATH:  1.10.268.10|3.90.199.10
PubMed:  11395412|9519293|17397985

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05560 super family cl35335
DNA gyrase subunit A; Validated
 1-306 0e+00

DNA gyrase subunit A; Validated


The actual alignment was detected with superfamily member PRK05560:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 701.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:PRK05560  84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:PRK05560 164 LVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKA 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  161 EIEEENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQD 240
Cdd:PRK05560 244 EIEEIKGREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQT 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77169158  241 TFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:PRK05560 324 SFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVI 389
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-306 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 701.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:PRK05560  84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:PRK05560 164 LVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKA 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  161 EIEEENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQD 240
Cdd:PRK05560 244 EIEEIKGREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQT 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77169158  241 TFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:PRK05560 324 SFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVI 389
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-306 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 685.23  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:COG0188  89 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNL 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:COG0188 169 LVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKA 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158 161 EIEE-ENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:COG0188 249 EIEElKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQ 328

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158 240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:COG0188 329 TSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVI 395
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-306 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 578.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:TIGR01063  80 DTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:TIGR01063 160 LVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   161 EIEE-ENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:TIGR01063 240 EIEEdSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQ 319

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158   240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:TIGR01063 320 VSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIALDNIDEVI 386
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-306 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 523.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:cd00187  58 DTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNL 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:cd00187 138 LVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKY 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158 161 EIEEENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQD 240
Cdd:cd00187 218 EIEDDEGRNTIEITELPYQVNKAKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQT 297

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158 241 TFGVIMLALV-DNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:cd00187 298 TFGINMVAFDpNGRPKKLNLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVI 364
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-306 4.56e-170

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 478.20  E-value: 4.56e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     1 DALVRMAQDFSLRYMLVDGHGNFGSV-DGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:pfam00521  55 DAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPN 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTslELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAK 159
Cdd:pfam00521 135 LLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEAT--LLMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAK 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   160 AEIEEENgrhKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDReGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:pfam00521 213 VEIEDRK---TIVITELPYGVWTSDLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQ 288

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158   240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:pfam00521 289 TSFSTNNLVLFDGGPKYLGLKEILKEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVI 355
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-306 5.11e-160

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 453.18  E-value: 5.11e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158      1 DALVRMAQDFSLRYMLVDGHGNFGSV-DGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:smart00434  77 DTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPN 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSgiraayetgkgRIVVRAK 159
Cdd:smart00434 157 LLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGK 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    160 AEIEEENgrhKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDES-DREGMRIVIELKRDANPNVTLNLLYKHTKM 238
Cdd:smart00434 226 IEIEDDN---TIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKL 302

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    239 QDTFGVIMLALVDN-QPQILNLKQVLVHYINFQKDVITRRTQFELNKAK-ERAHILEGLIIALDNIDEVI 306
Cdd:smart00434 303 QTTFSINMLALFDNgRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEII 372
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
 1-306 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 701.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:PRK05560  84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:PRK05560 164 LVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKA 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  161 EIEEENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQD 240
Cdd:PRK05560 244 EIEEIKGREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQLQT 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77169158  241 TFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:PRK05560 324 SFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVI 389
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-306 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 685.23  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:COG0188  89 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTVLPARFPNL 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:COG0188 169 LVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRGSIRVRAKA 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158 161 EIEE-ENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:COG0188 249 EIEElKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLNQLYKHTQLQ 328

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158 240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:COG0188 329 TSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVI 395
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
 1-306 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 578.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:TIGR01063  80 DTLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:TIGR01063 160 LVNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   161 EIEE-ENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:TIGR01063 240 EIEEdSKGREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQ 319

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158   240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:TIGR01063 320 VSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIALDNIDEVI 386
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-306 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 546.63  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:PRK05561  89 DAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLPARFPNL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAG-IIMGKSGIRAAYETGKGRIVVRAK 159
Cdd:PRK05561 169 LLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTGGeIITGRDGIRKAYETGRGSIRVRAR 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  160 AEIEEENGRHK-IIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREG-MRIVIELK-RDANPNVTLNLLYKHT 236
Cdd:PRK05561 249 WEIEDLAGGRWqIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENpVRIVIEPKsNRVDPEALMNHLFATT 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77169158  237 KMQDTFGVIMLAL-VDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:PRK05561 329 DLESSYRVNMNAIgLDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVI 399
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
 1-306 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 523.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:cd00187  58 DTIVRMAQDFSNNIPLLDPQGNFGSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNL 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:cd00187 138 LVNGSSGIAVGMATNIPPHNLREVIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKY 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158 161 EIEEENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQD 240
Cdd:cd00187 218 EIEDDEGRNTIEITELPYQVNKAKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQT 297

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158 241 TFGVIMLALV-DNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:cd00187 298 TFGINMVAFDpNGRPKKLNLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVI 364
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
1-306 4.56e-170

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 478.20  E-value: 4.56e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     1 DALVRMAQDFSLRYMLVDGHGNFGSV-DGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:pfam00521  55 DAIVRMAQDFVGNIPLLDGQGNFGSRiDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPN 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTslELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAK 159
Cdd:pfam00521 135 LLVNGAEGIAVGMATNIPPHNLREIIDALIALLDGPEAT--LLMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAK 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   160 AEIEEENgrhKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDReGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:pfam00521 213 VEIEDRK---TIVITELPYGVWTSDLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQ 288

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158   240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:pfam00521 289 TSFSTNNLVLFDGGPKYLGLKEILKEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVI 355
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
 1-306 5.11e-160

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 453.18  E-value: 5.11e-160
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158      1 DALVRMAQDFSLRYMLVDGHGNFGSV-DGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:smart00434  77 DTIVRMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPN 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSgiraayetgkgRIVVRAK 159
Cdd:smart00434 157 LLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIVGPG-----------KYVVRGK 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    160 AEIEEENgrhKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDES-DREGMRIVIELKRDANPNVTLNLLYKHTKM 238
Cdd:smart00434 226 IEIEDDN---TIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKL 302

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    239 QDTFGVIMLALVDN-QPQILNLKQVLVHYINFQKDVITRRTQFELNKAK-ERAHILEGLIIALDNIDEVI 306
Cdd:smart00434 303 QTTFSINMLALFDNgRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEII 372
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
 1-306 2.08e-141

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 422.59  E-value: 2.08e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:PRK13979  92 DAMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:PRK13979 172 LVNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKT 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  161 EIEE-ENGRHKIIVTELPYQVNKAKLIEYIADLVKDKK----ITGISDLRDESDREGMRIVIELKRDANPNV---TLNLL 232
Cdd:PRK13979 252 KIEKlENGRLGIVITEFPYRRNKAKLLQTISEMTADKKhskaLENISDIRDESDRNGIRAVIEFKKSADEDVaekVLKYL 331

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 77169158  233 YKHTKMQDTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:PRK13979 332 YKKTDLQCNISFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKRFHIVEGFIKAIGIMDEII 405
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
 1-306 6.22e-128

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 381.46  E-value: 6.22e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPNL 80
Cdd:TIGR01061  80 DAMVRMSQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    81 LVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGKSGIRAAYETGKGRIVVRAKA 160
Cdd:TIGR01061 160 LINGATGIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKI 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   161 EIEE-ENGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:TIGR01061 240 EIEVnKNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQ 319

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158   240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:TIGR01061 320 INYNFNMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGLIKAISIIDEII 386
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
 1-306 3.06e-111

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 338.42  E-value: 3.06e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     1 DALVRMAQDFSLRYMLVDGHGNFGSVDG-DSAAAMRYTEAKMNKIASEMLRDINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:TIGR01062  80 EAMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPN 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLELMTYIKGPDFPTAGIIMGK-SGIRAAYETGKGRIVVRA 158
Cdd:TIGR01062 160 ILLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAEIIDKaEEIRKIYETGRGSFRMRA 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   159 KAEIEEengrHKIIVTELPYQVNKAKLIEYIADLVKDKKITGISDLRDESDREG-MRIVIELK-RDANPNVTLNLLYKHT 236
Cdd:TIGR01062 240 RWKKED----GQIVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDHENpIRVVIVPRsNRVDPDIVMEHLFATT 315

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77169158   237 KMQDTFGVIMLAL-VDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILEGLIIALDNIDEVI 306
Cdd:TIGR01062 316 DLEKSYRLNMNMIgLDNVPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIAFLNIDEVI 386
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
 1-297 3.70e-45

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 161.80  E-value: 3.70e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQdfslRYMLVDGHGNFGSV-DGDSAAAMRYTEAKMNKIASEMLrdINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:PRK09631  74 EALVNLAN----KDLFIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPV 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIAlidnpELTSLELMTYikgPDFPTAGIIMgksgiRAAYETGKGRIVVRAK 159
Cdd:PRK09631 148 ILIQGAEGIAVGMATKILPHNFNEILQAVKS-----ELLGESFALY---PDFPTGGIVD-----VSEYADGNGKVLVRAK 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  160 AEIEEENgrhKIIVTELPYQVNKAKLIEYIADLVKDKKITgISDLRDESDrEGMRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:PRK09631 215 IETKDEK---TIVIREIPFGTTTESLIASIEKAARKGKIK-ISSINDYTA-ENVEIEIKLPRGVYASEVIEALYAYTDCE 289

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  240 DTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKER--AHILEGLII 297
Cdd:PRK09631 290 VSISVNLLVIKDRYPVIYTVTDIIKFHAEHLQKVLKMELELERAKLLEKifAKTLEQIFI 349
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
1-297 3.22e-39

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 146.30  E-value: 3.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQdfslRYMLVDGHGNFGSV-DGDSAAAMRYTEAKMNKIASEMLrdINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:PRK12758  93 DALVQLGQ----KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLelmtyikgPDFPTAGIIMgksgiRAAYETGK--GRIVVR 157
Cdd:PRK12758 167 LLAQGAEGIAVGLSTKILPHNFNELIDASIAYLKGKEFKLY--------PDFPTGGIID-----VSNYNDGErgGRVRVR 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  158 AKAEIEEENgrhKIIVTELPYQVNKAKLIEYIadlVK--DK---KITGISDLrdesDREGMRIVIELKRDANPNVTLNLL 232
Cdd:PRK12758 234 AKIEKLDKK---TLVITEIPYGTTTSSLIDSI---LKanDKgkiKIKKVEDN----TAADVEILVHLAPGVSPDKTIDAL 303

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77169158  233 YKHTKMQDTFGVIMLALVDNQPQILNLKQVLVHYINFQKDVITRRTQFELNKAKERAHI--LEGLII 297
Cdd:PRK12758 304 YAFTDCEVSISPNACVIIDNKPHFLGVSDILRRSTDHTVSLLKQELEIRLSELEEQWHFasLEKIFI 370
52 PHA02592
DNA topisomerase II medium subunit; Provisional
 1-288 2.02e-32

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 124.40  E-value: 2.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQDFSLRYMLVDGHGNFGSVDGDSAAAMRYTEAKMNKIASEMLRDInkntvDFTPNF-DGEEKEPVVLPSRYPN 79
Cdd:PHA02592  82 DAGALMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARVHDNFRKIYKDE-----DLAPVHeDPEHIPPAFYLPIIPM 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLElmtyIKGPDFptAGIIMgksgiraayETGKGRIVVRAK 159
Cdd:PHA02592 157 VLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPK----VQFPEF--KGEVV---------EIEPGSYEIRGT 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  160 AEIeeeNGRHKIIVTELPYQVNKAKLIEYIADLVKDKKITGIsdlrDESDREGMRIVIELKRDANPNVTlnllykHTKMQ 239
Cdd:PHA02592 222 YEL---NGKTKLHITEIPVKYDRETYVAVLDPLEEKGKIVSY----DDCTEDGFRFKVTLKREENEEAT------HEKIM 288

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77169158  240 DTFGVIMLalvdNQPQI--LNLKQVLVHY----------INFQKDVITRRTQFELNKAKER 288
Cdd:PHA02592 289 KDFGLIER----VSQNItvINENGKLKVYenaedlirdfVEIRKTYVQKRIQYEIKETEEA 345
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
 1-263 1.46e-31

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 122.70  E-value: 1.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    1 DALVRMAQdfslRYMLVDGHGNFGS-VDGDSAAAMRYTEAKMNKIASEMLrdINKNTVDFTPNFDGEEKEPVVLPSRYPN 79
Cdd:PRK09630  74 EALVVLAN----KGYLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   80 LLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLelmtyikgPDFPTAGiIMGKSgiraAYETGKGRIVVRAK 159
Cdd:PRK09630 148 LLLHGVDGIAVGMTTKIFPHNFCELLEAQIAILNDQPFTLL--------PDFPSGG-TMDAS----EYQDGLGSITLRAS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158  160 AEIEEENgrhKIIVTELPYQVNKAKLIEYIADLVKdKKITGISDLRDESDREGmRIVIELKRDANPNVTLNLLYKHTKMQ 239
Cdd:PRK09630 215 IDIINDK---TLLIKEICPSTTTETLIRSIENAAK-RGIIKIDSIQDFSTDLP-HIEIKLPKGIYAKDLLRPLFTHTECQ 289

                        250       260
                 ....*....|....*....|....
gi 77169158  240 DTFGVIMLALVDNQPQILNLKQVL 263
Cdd:PRK09630 290 VILTSRPTAIYQNKPVETSISEIL 313
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 3-294 5.52e-12

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 66.27  E-value: 5.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     3 LVRMAQDF--SLRYMLVDGHGNFGS--VDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTpNFDGEEKEPVVLPSRYP 78
Cdd:PLN03128  728 IIGMAQDFvgSNNINLLTPSGQFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYL-NEDGQSIEPEWYCPIIP 806

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    79 NLLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTSLElmTYIKGpdFptagiimgKSGIRAAYETGKGRIVVRA 158
Cdd:PLN03128  807 MVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMH--PWYRG--F--------KGTITEVSTSRSGSYTVTG 874

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   159 KAEIEEENgrhKIIVTELPYQV---NKAKLIEYIADLVKDKKiTGISDLRDESDREGMRIVIELKRDANPNVTLNLLYKH 235
Cdd:PLN03128  875 IIEQIGDT---TIRITELPVRKwtqDYKEFLEALLTGTKKKE-PEIKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKK 950

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 77169158   236 TKMQDTFGVIMLALVDNQPQILNLKQVLVHYINF----------QKDVITRRTQFELNKAKERAHILEG 294
Cdd:PLN03128  951 FKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFfhlrldlyvkRKEVLLENLEYELKKLDNKARFILA 1019
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 4-293 9.17e-12

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 65.84  E-value: 9.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     4 VRMAQDF----SLRYMLVDGHgnFGS--VDGDSAAAMRYTEAKMNKIAsemlRDINKNTVDFTPNFDGEEKEpVVLPSRY 77
Cdd:PTZ00108  736 VGMAQNFvgsnNINLLYPCGQ--FGSrlQGGKDHAAARYIFTKLSKIT----RYIFPEEDDPILDYLEDDGQ-SVEPFYY 808

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158    78 ----PNLLVNGSSGIAVGMATNIPPHNLGEVIDGTIALIDNPELTslELMTYIKGPDfptaGIIMgksgiraayETGKGR 153
Cdd:PTZ00108  809 vpiiPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVR--PLVPWYRGFK----GTIE---------RNPKGK 873

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158   154 IVVRAKAEIEEENgrhKIIVTELPYQVNKAKLIEYIADLVKDKKITgISDLRDESDREGMRIVIELKRDANPNVTLNLLY 233
Cdd:PTZ00108  874 FISKGIYEKVPDG---TVEITELPIGKWTEDYKEFLESETLKEKDV-IVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIE 949

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 77169158   234 KHTKMQDTFGVIMLALVDNQPQI---LNLKQVLVHYINFQKDVITRRTQFELNKAKERAHILE 293
Cdd:PTZ00108  950 KVFKLKSTISTTNMVLFDENGKIkkySDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLS 1012
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
 2-106 7.66e-06

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 47.55  E-value: 7.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77169158     2 ALVRMAQDF--SLRYMLVDGHGNFG--SVDGDSAAAMRYTEAKMNKIASEMLRDINKNTVDFTpNFDGEEKEPVVLPSRY 77
Cdd:PLN03237  752 TIIGMAQDFvgSNNINLLLPNGQFGtrLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYL-NEDGQSIEPTWYMPII 830

                          90       100
                  ....*....|....*....|....*....
gi 77169158    78 PNLLVNGSSGIAVGMATNIPPHNLGEVID 106
Cdd:PLN03237  831 PTVLVNGAEGIGTGWSTFIPNYNPRDIVA 859
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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