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Conserved domains on  [gi|77735633|ref|NP_001029512|]
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CCN family member 1 precursor [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 230-273 5.32e-18

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 76.60  E-value: 5.32e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 77735633   230 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 273
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 294-376 4.32e-14

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member pfam00007:

Pssm-ID: 473907  Cd Length: 105  Bit Score: 67.82  E-value: 4.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735633   294 PEPVHFTYAGCSSVKKYRPKYC-GSCV-------DGR-------CCTPQQTRTVKMRFRCEDGEMFSKNVMMIQSCRCNy 358
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86

                          90
                  ....*....|....*...
gi 77735633   359 NCPHANEAAFPFYRLFND 376
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDS 104
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 9.55e-10

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 53.87  E-value: 9.55e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 77735633    26 CPTAC---HCPLEAPKCAPGVglVRDACGCCKVCAKQLNEDCS-KTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 7.00e-08

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 48.67  E-value: 7.00e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77735633    100 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNLRLVKVTGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 230-273 5.32e-18

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 76.60  E-value: 5.32e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 77735633   230 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 273
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 294-376 4.32e-14

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 67.82  E-value: 4.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735633   294 PEPVHFTYAGCSSVKKYRPKYC-GSCV-------DGR-------CCTPQQTRTVKMRFRCEDGEMFSKNVMMIQSCRCNy 358
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86

                          90
                  ....*....|....*...
gi 77735633   359 NCPHANEAAFPFYRLFND 376
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 293-361 1.17e-11

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 60.11  E-value: 1.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735633    293 SPEPVHFTYAGCSSVKkYRPKYC-GSCVD------------GRCCTPQQTRTVKMRFRCEDGEMFSKNVMMIQSCRCNYN 359
Cdd:smart00041   2 SPVRQTITYNGCTSVT-VKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80


                   ..
gi 77735633    360 CP 361
Cdd:smart00041  81 CP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 9.55e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 53.87  E-value: 9.55e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 77735633    26 CPTAC---HCPLEAPKCAPGVglVRDACGCCKVCAKQLNEDCS-KTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 7.00e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 48.67  E-value: 7.00e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77735633    100 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNLRLVKVTGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 32-84 2.73e-07

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 47.46  E-value: 2.73e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 77735633     32 CPLEAPKCApgVGLVRDACGCCKVCAKQLNEDCSK-TQPCdhTKGLECNFGANS 84
Cdd:smart00121  11 CPPCPPGCA--ELVRLDGCGCCPVCARQEGEPCGVyTPRC--APGLRCQPPPGE 60
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 6.20e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 6.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77735633   100 CEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPNLRLVKVTGQCCEE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 233-273 8.74e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 8.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 77735633    233 QTTSWSQCSKTCGTGISTRV--------TNDNPECR-LVKETRICEVRPC 273
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 230-273 5.32e-18

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 76.60  E-value: 5.32e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 77735633   230 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 273
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 294-376 4.32e-14

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 67.82  E-value: 4.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735633   294 PEPVHFTYAGCSSVKKYRPKYC-GSCV-------DGR-------CCTPQQTRTVKMRFRCEDGEMFSKNVMMIQSCRCNy 358
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86

                          90
                  ....*....|....*...
gi 77735633   359 NCPHANEAAFPFYRLFND 376
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 293-361 1.17e-11

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 60.11  E-value: 1.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77735633    293 SPEPVHFTYAGCSSVKkYRPKYC-GSCVD------------GRCCTPQQTRTVKMRFRCEDGEMFSKNVMMIQSCRCNYN 359
Cdd:smart00041   2 SPVRQTITYNGCTSVT-VKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80


                   ..
gi 77735633    360 CP 361
Cdd:smart00041  81 CP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 9.55e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 53.87  E-value: 9.55e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 77735633    26 CPTAC---HCPLEAPKCAPGVglVRDACGCCKVCAKQLNEDCS-KTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 7.00e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 48.67  E-value: 7.00e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 77735633    100 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNLRLVKVTGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 32-84 2.73e-07

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 47.46  E-value: 2.73e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 77735633     32 CPLEAPKCApgVGLVRDACGCCKVCAKQLNEDCSK-TQPCdhTKGLECNFGANS 84
Cdd:smart00121  11 CPPCPPGCA--ELVRLDGCGCCPVCARQEGEPCGVyTPRC--APGLRCQPPPGE 60
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 6.20e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 45.88  E-value: 6.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 77735633   100 CEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPNLRLVKVTGQCCEE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 235-273 6.92e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 6.92e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 77735633   235 TSWSQCSKTCGTGISTRV-------TNDNPECRLVKETRICEVRPC 273
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 233-273 8.74e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 8.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 77735633    233 QTTSWSQCSKTCGTGISTRV--------TNDNPECR-LVKETRICEVRPC 273
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 233-273 1.27e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 1.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 77735633   233 QTTSWSQCSKTCGTGISTRV----------TNDNPECRLVK---ETRICEVRPC 273
Cdd:pfam19030   2 VAGPWGECSVTCGGGVQTRLvqcvqkgggsIVPDSECSAQKkppETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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