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Conserved domains on  [gi|80474733|gb|AAI08964|]
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Btla protein [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 40-142 1.60e-36

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20928:

Pssm-ID: 472250  Cd Length: 101  Bit Score: 126.36  E-value: 1.60e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80474733  40 CEVQLNIKRNSKHSAWTGELFKIECPVKYCVHRPNVTWCKHNGTIWVPLEvgpQLYTSWEENRSVPVFVLHFKPIHLSDN 119
Cdd:cd20928   1 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLE---DRQTSWKEEKNISFFILHFEPVLPNDN 77

                        90       100
                ....*....|....*....|...
gi 80474733 120 GSYSCSTNFNSQVINSHSVTIHV 142
Cdd:cd20928  78 GSYRCSANFQSNLIESHSTTLYV 100
 
Name Accession Description Interval E-value
IgI_BTLA cd20928
Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member ...
 40-142 1.60e-36

Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member of the I-set Ig superfamily domains; The members here are composed of the extracellular immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA; also known as CD270). BTLA is a type I transmembrane glycoprotein that is structurally similar to the CD28 family of T cell co-stimulatory or coinhibitory molecules. BTLA is a coinhibitory molecule expressed on T cells, B cells, macrophages, dendritic and natural killer (NK) cells. Unlike CD28 family members, BTLA interacts with the tumor necrosis factor receptor superfamily member HVEM (herpes virus entry mediator) rather than with B7 family ligands. In addition, BTLA does not form a homodimer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. In contrast to CD28 family members, the structure of the BTLA extracellular Ig domain lacks a C" strand and thus is better described as a member of the I-set of Ig domains. I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM).


Pssm-ID: 409522  Cd Length: 101  Bit Score: 126.36  E-value: 1.60e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80474733  40 CEVQLNIKRNSKHSAWTGELFKIECPVKYCVHRPNVTWCKHNGTIWVPLEvgpQLYTSWEENRSVPVFVLHFKPIHLSDN 119
Cdd:cd20928   1 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLE---DRQTSWKEEKNISFFILHFEPVLPNDN 77

                        90       100
                ....*....|....*....|...
gi 80474733 120 GSYSCSTNFNSQVINSHSVTIHV 142
Cdd:cd20928  78 GSYRCSANFQSNLIESHSTTLYV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 97-143 4.97e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 38.98  E-value: 4.97e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 80474733    97 SWEENRSVPVFVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTIHVR 143
Cdd:pfam07686  63 SGRGDPSNGDGSLTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 50-142 1.48e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80474733     50 SKHSAWTGELFKIECPVKYCVHrPNVTWCKHNGTiwvplEVGPQLYTSWEENRSVpvFVLHFKPIHLSDNGSYSCSTNfN 129
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPP-PEVTWYKQGGK-----LLAESGRFSVSRSGST--STLTISNVTPEDSGTYTCAAT-N 72

                           90
                   ....*....|...
gi 80474733    130 SQVINSHSVTIHV 142
Cdd:smart00410  73 SSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgI_BTLA cd20928
Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member ...
 40-142 1.60e-36

Extracellular Immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA); member of the I-set Ig superfamily domains; The members here are composed of the extracellular immunoglobulin (Ig) domain of the B and T lymphocyte attenuator (BTLA; also known as CD270). BTLA is a type I transmembrane glycoprotein that is structurally similar to the CD28 family of T cell co-stimulatory or coinhibitory molecules. BTLA is a coinhibitory molecule expressed on T cells, B cells, macrophages, dendritic and natural killer (NK) cells. Unlike CD28 family members, BTLA interacts with the tumor necrosis factor receptor superfamily member HVEM (herpes virus entry mediator) rather than with B7 family ligands. In addition, BTLA does not form a homodimer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. In contrast to CD28 family members, the structure of the BTLA extracellular Ig domain lacks a C" strand and thus is better described as a member of the I-set of Ig domains. I-set domains are found in several cell adhesion molecules, including vascular (VCAM), intercellular (ICAM), neural (NCAM) and mucosal addressin (MADCAM) cell adhesion molecules, as well as junction adhesion molecules (JAM).


Pssm-ID: 409522  Cd Length: 101  Bit Score: 126.36  E-value: 1.60e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80474733  40 CEVQLNIKRNSKHSAWTGELFKIECPVKYCVHRPNVTWCKHNGTIWVPLEvgpQLYTSWEENRSVPVFVLHFKPIHLSDN 119
Cdd:cd20928   1 CDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLE---DRQTSWKEEKNISFFILHFEPVLPNDN 77

                        90       100
                ....*....|....*....|...
gi 80474733 120 GSYSCSTNFNSQVINSHSVTIHV 142
Cdd:cd20928  78 GSYRCSANFQSNLIESHSTTLYV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 97-143 4.97e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 38.98  E-value: 4.97e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 80474733    97 SWEENRSVPVFVLHFKPIHLSDNGSYSCSTNFNSQVINSHSVTIHVR 143
Cdd:pfam07686  63 SGRGDPSNGDGSLTIQNLTLSDSGTYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 50-142 1.48e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 80474733     50 SKHSAWTGELFKIECPVKYCVHrPNVTWCKHNGTiwvplEVGPQLYTSWEENRSVpvFVLHFKPIHLSDNGSYSCSTNfN 129
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPP-PEVTWYKQGGK-----LLAESGRFSVSRSGST--STLTISNVTPEDSGTYTCAAT-N 72

                           90
                   ....*....|...
gi 80474733    130 SQVINSHSVTIHV 142
Cdd:smart00410  73 SSGSASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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