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Conserved domains on  [gi|814539037|emb|CNG08131|]
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alkylhydroperoxidase AhpD family core domain-containing protein [Mycobacterium tuberculosis]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 11450212)

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 51-172 9.17e-22

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


:

Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 86.09  E-value: 9.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814539037  51 LFWTFAIYTGRLL-HGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAWPDVPDgdgprkvLSARQ 129
Cdd:COG2128    5 LLKAFLALSGALMaKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPL-------FDPRE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 814539037 130 QALLQATDELIKDR-TITAGTWERLATHLDPRLLIEFCLLATQY 172
Cdd:COG2128   78 RAALAFAEALTRTPgGVSDADVAALRAGFSDAEIVELVLAIALF 121
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 51-172 9.17e-22

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 86.09  E-value: 9.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814539037  51 LFWTFAIYTGRLL-HGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAWPDVPDgdgprkvLSARQ 129
Cdd:COG2128    5 LLKAFLALSGALMaKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPL-------FDPRE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 814539037 130 QALLQATDELIKDR-TITAGTWERLATHLDPRLLIEFCLLATQY 172
Cdd:COG2128   78 RAALAFAEALTRTPgGVSDADVAALRAGFSDAEIVELVLAIALF 121
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 53-138 4.97e-10

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 53.85  E-value: 4.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814539037   53 WTFAIYTGRLLHGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAWPDVPDGdgprkvlSARQQAL 132
Cdd:pfam02627   6 ALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAG-------GPAARAA 78


                  ....*.
gi 814539037  133 LQATDE 138
Cdd:pfam02627  79 LAAAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 65-112 1.34e-03

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 35.42  E-value: 1.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 814539037   65 GRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAW 112
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAW 48
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 51-172 9.17e-22

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 86.09  E-value: 9.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814539037  51 LFWTFAIYTGRLL-HGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAWPDVPDgdgprkvLSARQ 129
Cdd:COG2128    5 LLKAFLALSGALMaKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPL-------FDPRE 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 814539037 130 QALLQATDELIKDR-TITAGTWERLATHLDPRLLIEFCLLATQY 172
Cdd:COG2128   78 RAALAFAEALTRTPgGVSDADVAALRAGFSDAEIVELVLAIALF 121
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 53-138 4.97e-10

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 53.85  E-value: 4.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 814539037   53 WTFAIYTGRLLHGRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAWPDVPDGdgprkvlSARQQAL 132
Cdd:pfam02627   6 ALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAG-------GPAARAA 78


                  ....*.
gi 814539037  133 LQATDE 138
Cdd:pfam02627  79 LAAAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 65-112 1.34e-03

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 35.42  E-value: 1.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 814539037   65 GRLPGVDTELVILRVAHLRSCEYELQHHRRMARRRGLDANTQATIFAW 112
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAW 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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