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Conserved domains on  [gi|814539045|emb|CNG08382|]
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Putative 1%2C4-Dihydroxy-2-naphtoate prenyltransferase (part1) [Mycobacterium tuberculosis]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenA super family cl42361
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
 33-98 2.10e-03

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


The actual alignment was detected with superfamily member COG1575:

Pssm-ID: 441183  Cd Length: 290  Bit Score: 37.43  E-value: 2.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 814539045  33 RWLVVTRAAVLPMTLVSGLVAGLLAIGEPGlDWRWLVLWWeshAP------HIANNLMNDLYDTDVGTDSAT 98
Cdd:COG1575    1 AWLEAARPRTLPAAVAPVLLGTALAYYETG-SFNWLLFLL---ALlaalllQIGVNLANDYFDYKKGTDTEE 68
 
Name Accession Description Interval E-value
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
 33-98 2.10e-03

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 37.43  E-value: 2.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 814539045  33 RWLVVTRAAVLPMTLVSGLVAGLLAIGEPGlDWRWLVLWWeshAP------HIANNLMNDLYDTDVGTDSAT 98
Cdd:COG1575    1 AWLEAARPRTLPAAVAPVLLGTALAYYETG-SFNWLLFLL---ALlaalllQIGVNLANDYFDYKKGTDTEE 68
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 38-99 2.52e-03

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 37.11  E-value: 2.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 814539045  38 TRAAVLPMTLVSGLVAGLLAIGEPGLDWRWLVLWwes--hapHIANNLMNDLYDTDVGTDSATY 99
Cdd:cd13962    4 ARPRTLPASLAPVLLGTALAYYLGGFFNWLLFLLallaalllQIGVNLANDYFDYKKGTDTEPR 67
 
Name Accession Description Interval E-value
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
 33-98 2.10e-03

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 37.43  E-value: 2.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 814539045  33 RWLVVTRAAVLPMTLVSGLVAGLLAIGEPGlDWRWLVLWWeshAP------HIANNLMNDLYDTDVGTDSAT 98
Cdd:COG1575    1 AWLEAARPRTLPAAVAPVLLGTALAYYETG-SFNWLLFLL---ALlaalllQIGVNLANDYFDYKKGTDTEE 68
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 38-99 2.52e-03

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 37.11  E-value: 2.52e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 814539045  38 TRAAVLPMTLVSGLVAGLLAIGEPGLDWRWLVLWwes--hapHIANNLMNDLYDTDVGTDSATY 99
Cdd:cd13962    4 ARPRTLPASLAPVLLGTALAYYLGGFFNWLLFLLallaalllQIGVNLANDYFDYKKGTDTEPR 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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