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Conserved domains on  [gi|816388016|gb|KKK40325|]
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MAG: Beta-carbonic anhydrase 1 [Candidatus Lokiarchaeum sp. GC14_75]

Protein Classification

carbonic anhydrase( domain architecture ID 10658772)

carbonic anhydrase (CA) catalyzes the zinc-dependent reversible hydration of carbon dioxide into bicarbonate and a proton

CATH:  3.40.1050.10
EC:  4.2.1.1
Gene Ontology:  GO:0004089|GO:0008270
PubMed:  11696553|9336012
SCOP:  4000510

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 37-179 3.62e-30

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


:

Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 111.44  E-value: 3.62e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016    37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CSQDSLRSILLAIYQYNIKYIIILGHLDCGMTKINLLELKRNVP 113
Cdd:smart00947   8 ALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIvppYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAALDDEPGLID 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 816388016   114 --YEFLPNTSNETLDLFAETRELfkpfndELRNIKQQMETLHR---LQLH--NQEVKILGMLYDVETGWVLEY 179
Cdd:smart00947  88 nwLERIRPARERALEELGDVDAL------EELNVRDQVENLRTspaIREAvaKGKLKVHGWVYDIETGKLEVL 154
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 37-179 3.62e-30

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 111.44  E-value: 3.62e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016    37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CSQDSLRSILLAIYQYNIKYIIILGHLDCGMTKINLLELKRNVP 113
Cdd:smart00947   8 ALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIvppYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAALDDEPGLID 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 816388016   114 --YEFLPNTSNETLDLFAETRELfkpfndELRNIKQQMETLHR---LQLH--NQEVKILGMLYDVETGWVLEY 179
Cdd:smart00947  88 nwLERIRPARERALEELGDVDAL------EELNVRDQVENLRTspaIREAvaKGKLKVHGWVYDIETGKLEVL 154
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-174 9.63e-30

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 110.03  E-value: 9.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQDSLRSILLAIYQYNIKYIIILGHLDCGMTKINLLELKRNVPyEF 116
Cdd:cd03379    5 LAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRVTDDAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEELKEKMK-ER 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 816388016 117 LPNTSNETLDLFAEtrelFKPFNDELRNIKQQMETLHRLQLHNQEVKILGMLYDVETG 174
Cdd:cd03379   84 GIAEAYGGIDKEFW----FLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTG 137
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 37-174 2.67e-26

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 101.43  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016   37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CSQDSLRSILLAIYQYNIKYIIILGHLDCGMTKINLLELKRNVP 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLvppYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAAGPAEL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 816388016  114 YEFLPN------TSNETLDLFAETRELFKPFNDEL--RNIKQQMETLHR---LQ--LHNQEVKILGMLYDVETG 174
Cdd:pfam00484  81 PGFIDNwlrhirPAVERVAEELESLDDPEERDDALeeLNVREQVENLRTfpiVReaVAKGKLKIHGWVYDLETG 154
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-185 9.03e-25

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 98.70  E-value: 9.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016   1 MLDIKRmLIEGNLRFHLKI-NQDLENIEtkiKL-----PRYpvLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CS 71
Cdd:COG0288    1 MEALKR-LLEGNRRFVAGKfPQDPERFE---ELakgqhPFA--LVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVvppYD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  72 QDSLRSILLAIYQYNIKYIIILGHLDCGMTKiNLLELKRNVPYEFLPNtsneTLDLFAETRELFKPFND----------- 140
Cdd:COG0288   75 PGVLASIEYAVEVLGVKLIVVLGHSGCGAVK-AALDGLELEELGLIGN----WLRHIRPAVERVRAELPaadgeerldrl 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 816388016 141 ELRNIKQQMETLHR---LQ--LHNQEVKILGMLYDVETGWVLEY----ERFKEI 185
Cdd:COG0288  150 VELNVREQVENLRTspiVReaVAAGKLKVHGWVYDLATGRVEFLdpegGGFEPL 203
PRK15219 PRK15219
carbonic anhydrase; Provisional
 4-176 9.71e-08

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 52.14  E-value: 9.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016   4 IKRMLIEGNLRF-------HLKINQDLENIETKiklprYPV-LILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQDSL 75
Cdd:PRK15219  56 IIESLKQGNKRFrsgkpaqHDYLAQKRASAAGQ-----YPAaVILSCIDSRAPAEIILDTGIGETFNSRVAGNISNDDLL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  76 RSILLAIYQYNIKYIIILGHLDCGMTK--INLLE-------LKRNVP------YEFLPNTSNET-LDLFAETrelfkpfN 139
Cdd:PRK15219 131 GSMEFACAVAGAKVVLVMGHTACGAVKgaIDNVElgnltglLDRIKPaievteFDGERSSKNYKfVDAVARK-------N 203

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 816388016 140 DEL--RNIKQQMETLHRLQlHNQEVKILGMLYDVETGWV 176
Cdd:PRK15219 204 VELtiENIRKNSPILRKLE-QEGKIKIVGSMYNLNGGKV 241
 
Name Accession Description Interval E-value
Pro_CA smart00947
Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the ...
 37-179 3.62e-30

Carbonic anhydrase; Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.


Pssm-ID: 214929 [Multi-domain]  Cd Length: 154  Bit Score: 111.44  E-value: 3.62e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016    37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CSQDSLRSILLAIYQYNIKYIIILGHLDCGMTKINLLELKRNVP 113
Cdd:smart00947   8 ALIIGCSDSRVPPELIFGLGPGDLFVIRNAGNIvppYDDGVLASLEYAVEVLGVKEIVVCGHTDCGAVKAALDDEPGLID 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 816388016   114 --YEFLPNTSNETLDLFAETRELfkpfndELRNIKQQMETLHR---LQLH--NQEVKILGMLYDVETGWVLEY 179
Cdd:smart00947  88 nwLERIRPARERALEELGDVDAL------EELNVRDQVENLRTspaIREAvaKGKLKVHGWVYDIETGKLEVL 154
beta_CA_cladeD cd03379
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-174 9.63e-30

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239474  Cd Length: 142  Bit Score: 110.03  E-value: 9.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQDSLRSILLAIYQYNIKYIIILGHLDCGMTKINLLELKRNVPyEF 116
Cdd:cd03379    5 LAIVTCMDARLDPEKALGLKLGDAKVIRNAGGRVTDDAIRSLVVSVYLLGTREIIVIHHTDCGMLTFTDEELKEKMK-ER 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 816388016 117 LPNTSNETLDLFAEtrelFKPFNDELRNIKQQMETLHRLQLHNQEVKILGMLYDVETG 174
Cdd:cd03379   84 GIAEAYGGIDKEFW----FLGFDDLEESVREDVERIRNHPLIPDDVPVHGYVYDVKTG 137
beta_CA cd00382
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-179 1.11e-26

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238224 [Multi-domain]  Cd Length: 119  Bit Score: 101.04  E-value: 1.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQ---DSLRSILLAIYQYNIKYIIILGHLDCGMTKInllelkrnvp 113
Cdd:cd00382    5 ALIIGCSDSRVPPELIFGLGPGDLFVVRNAGNLVPPydlDVLASLEYAVEVLGVKHIIVCGHTDCGAVKA---------- 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 816388016 114 yeflpntsnetldlfaetrelfkpfnDELRNIKQQMETL--H---RLQLHNQEVKILGMLYDVETGWVLEY 179
Cdd:cd00382   75 --------------------------LVEENVREQVENLrsHpliQEAVAPGELKVHGWVYDIETGKLEVL 119
Pro_CA pfam00484
Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of ...
 37-174 2.67e-26

Carbonic anhydrase; This family includes carbonic anhydrases as well as a family of non-functional homologs related to YbcF.


Pssm-ID: 459828  Cd Length: 156  Bit Score: 101.43  E-value: 2.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016   37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CSQDSLRSILLAIYQYNIKYIIILGHLDCGMTKINLLELKRNVP 113
Cdd:pfam00484   1 ALIIGCSDSRVPPELIFDTGPGDLFVVRNAGNLvppYDLNVLASIEYAVEVLKVKHIVVCGHSGCGAVKAALDAAGPAEL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 816388016  114 YEFLPN------TSNETLDLFAETRELFKPFNDEL--RNIKQQMETLHR---LQ--LHNQEVKILGMLYDVETG 174
Cdd:pfam00484  81 PGFIDNwlrhirPAVERVAEELESLDDPEERDDALeeLNVREQVENLRTfpiVReaVAKGKLKIHGWVYDLETG 154
CynT COG0288
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-185 9.03e-25

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 440057  Cd Length: 204  Bit Score: 98.70  E-value: 9.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016   1 MLDIKRmLIEGNLRFHLKI-NQDLENIEtkiKL-----PRYpvLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CS 71
Cdd:COG0288    1 MEALKR-LLEGNRRFVAGKfPQDPERFE---ELakgqhPFA--LVIGCSDSRVPPELIFDQGPGDLFVVRNAGNVvppYD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  72 QDSLRSILLAIYQYNIKYIIILGHLDCGMTKiNLLELKRNVPYEFLPNtsneTLDLFAETRELFKPFND----------- 140
Cdd:COG0288   75 PGVLASIEYAVEVLGVKLIVVLGHSGCGAVK-AALDGLELEELGLIGN----WLRHIRPAVERVRAELPaadgeerldrl 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 816388016 141 ELRNIKQQMETLHR---LQ--LHNQEVKILGMLYDVETGWVLEY----ERFKEI 185
Cdd:COG0288  150 VELNVREQVENLRTspiVReaVAAGKLKVHGWVYDLATGRVEFLdpegGGFEPL 203
beta_CA_cladeB cd00884
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 37-179 1.04e-17

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238449  Cd Length: 190  Bit Score: 79.12  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNL---CSQDSLR-----SILLAIYQYNIKYIIILGHLDCGmtKINLLEL 108
Cdd:cd00884   28 ALFIACSDSRVVPALITQTQPGELFVVRNVGNLvppYEPDGGFhgtsaAIEYAVAVLKVEHIVVCGHSDCG--GIRALLS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016 109 KRNVPYEfLPNTSN--ETLDLFAETRELFKPFND--------ELRNIKQQMETL------------HRLQLHnqevkilG 166
Cdd:cd00884  106 PEDLLDK-LPFIGKwlRIAEPAKEVVLAELSHADfddqlralEKENVLLSLENLltypfvrerleaGTLSLH-------G 177

                        170
                 ....*....|...
gi 816388016 167 MLYDVETGWVLEY 179
Cdd:cd00884  178 WYYDIETGELYAY 190
beta_CA_cladeC cd03378
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 6-176 4.52e-15

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 239473 [Multi-domain]  Cd Length: 154  Bit Score: 71.02  E-value: 4.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016   6 RMLIEGNLRF----HLKINQDLENIETKIKlPRYP-VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQDSLRSILL 80
Cdd:cd03378    6 ERLKEGNKRFvsgkPLHPDQDLARRRELAK-GQKPfAVILSCSDSRVPPEIIFDQGLGDLFVVRVAGNIVDDDVLGSLEY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  81 AIYQYNIKYIIILGHLDCG-----MTKINlleLKRNVpyeflpntsnetldlfaetrelfkpfndelRNIKQQMETLHRL 155
Cdd:cd03378   85 AVEVLGVPLVVVLGHESCGavaaaAVRAN---VKATV------------------------------AKLRSRSPIIAEL 131

                        170       180
                 ....*....|....*....|.
gi 816388016 156 qLHNQEVKILGMLYDVETGWV 176
Cdd:cd03378  132 -VAAGKLKIVGAYYDLDTGKV 151
beta_CA_cladeA cd00883
Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of ...
 42-174 2.09e-10

Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. CAs are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionarily distinct families of CAs (the alpha-, beta-, and gamma-CAs) which show no significant sequence identity or structural similarity. Within the beta-CA family there are four evolutionarily distinct clades (A through D). The beta-CAs are multimeric enzymes (forming dimers,tetramers,hexamers and octamers) which are present in higher plants, algae, fungi, archaea and prokaryotes.


Pssm-ID: 238448  Cd Length: 182  Bit Score: 58.73  E-value: 2.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  42 CMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQDSLRSilLAIYQY-----NIKYIIILGHLDCGMTKINLLELKRNVPYEF 116
Cdd:cd00883   32 CSDSRVPENTILGLLPGEVFVHRNIANLVSPTDLNC--LSVLQYavdvlKVKHIIVCGHYGCGGVKAALTGKRLGLLDNW 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 816388016 117 LPNtsnetldlfaeTRELFKPFNDELRNIKQQMETLHRL-------QLHN--------------QEVKILGMLYDVETG 174
Cdd:cd00883  110 LRP-----------IRDVYRLHAAELDALEDEEERVDRLvelnvveQVKNlcktpivqdawkrgQELEVHGWVYDLGDG 177
PRK15219 PRK15219
carbonic anhydrase; Provisional
 4-176 9.71e-08

carbonic anhydrase; Provisional


Pssm-ID: 237927 [Multi-domain]  Cd Length: 245  Bit Score: 52.14  E-value: 9.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016   4 IKRMLIEGNLRF-------HLKINQDLENIETKiklprYPV-LILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQDSL 75
Cdd:PRK15219  56 IIESLKQGNKRFrsgkpaqHDYLAQKRASAAGQ-----YPAaVILSCIDSRAPAEIILDTGIGETFNSRVAGNISNDDLL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  76 RSILLAIYQYNIKYIIILGHLDCGMTK--INLLE-------LKRNVP------YEFLPNTSNET-LDLFAETrelfkpfN 139
Cdd:PRK15219 131 GSMEFACAVAGAKVVLVMGHTACGAVKgaIDNVElgnltglLDRIKPaievteFDGERSSKNYKfVDAVARK-------N 203

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 816388016 140 DEL--RNIKQQMETLHRLQlHNQEVKILGMLYDVETGWV 176
Cdd:PRK15219 204 VELtiENIRKNSPILRKLE-QEGKIKIVGSMYNLNGGKV 241
PRK10437 PRK10437
carbonic anhydrase; Provisional
 33-99 5.20e-07

carbonic anhydrase; Provisional


Pssm-ID: 182460  Cd Length: 220  Bit Score: 49.55  E-value: 5.20e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 816388016  33 PRYpvLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQDSLRSilLAIYQY-----NIKYIIILGHLDCG 99
Cdd:PRK10437  35 PRF--LWIGCSDSRVPAERLTGLEPGELFVHRNVANLVIHTDLNC--LSVVQYavdvlEVEHIIICGHYGCG 102
PLN00416 PLN00416
carbonate dehydratase
 20-102 8.08e-06

carbonate dehydratase


Pssm-ID: 177809  Cd Length: 258  Bit Score: 46.18  E-value: 8.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  20 NQDLENIETKIKLPRYpvLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQ-DSLR------SILLAIYQYNIKYIII 92
Cdd:PLN00416  67 NSTLFNHLAKTQTPKF--LVFACSDSRVCPSHILNFQPGEAFVVRNIANMVPPfDQKRhsgvgaAVEYAVVHLKVENILV 144

                         90
                 ....*....|
gi 816388016  93 LGHLDCGMTK 102
Cdd:PLN00416 145 IGHSCCGGIK 154
PLN03014 PLN03014
carbonic anhydrase
 33-102 7.35e-05

carbonic anhydrase


Pssm-ID: 178588 [Multi-domain]  Cd Length: 347  Bit Score: 43.96  E-value: 7.35e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 816388016  33 PRYpvLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQ-DSLR------SILLAIYQYNIKYIIILGHLDCGMTK 102
Cdd:PLN03014 160 PKY--MVFACSDSRVCPSHVLDFQPGDAFVVRNIANMVPPfDKVKyggvgaAIEYAVLHLKVENIVVIGHSACGGIK 234
PLN02154 PLN02154
carbonic anhydrase
 37-99 2.29e-04

carbonic anhydrase


Pssm-ID: 215111  Cd Length: 290  Bit Score: 42.04  E-value: 2.29e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 816388016  37 VLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCS------QDSLRSILLAIYQYNIKYIIILGHLDCG 99
Cdd:PLN02154 109 VMVIGCADSRVCPSYVLGFQPGEAFTIRNVANLVTpvqngpTETNSALEFAVTTLQVENIIVMGHSNCG 177
PLN03019 PLN03019
carbonic anhydrase
 33-102 2.72e-04

carbonic anhydrase


Pssm-ID: 166660  Cd Length: 330  Bit Score: 42.06  E-value: 2.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 816388016  33 PRYpvLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLCSQ-DSLR------SILLAIYQYNIKYIIILGHLDCGMTK 102
Cdd:PLN03019 155 PKY--MVFACSDSRVCPSHVLDFHPGDAFVVRNIANMVPPfDKVKyagvgaAIEYAVLHLKVENIVVIGHSACGGIK 229
PLN03006 PLN03006
carbonate dehydratase
 17-99 2.87e-04

carbonate dehydratase


Pssm-ID: 178583  Cd Length: 301  Bit Score: 41.65  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 816388016  17 LKINQDLENIET--KIKLPRYpvLILTCMDPRIDIHRIFQLDPGDVFVLRNAGNLC------SQDSLRSILLAIYQYNIK 88
Cdd:PLN03006  95 LKYMDDFEHYKNlaDAQAPKF--LVIACADSRVCPSAVLGFQPGDAFTVRNIANLVppyesgPTETKAALEFSVNTLNVE 172

                         90
                 ....*....|.
gi 816388016  89 YIIILGHLDCG 99
Cdd:PLN03006 173 NILVIGHSRCG 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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