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Conserved domains on  [gi|81987336|sp|Q6UDF2|]
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RecName: Full=Major viral transcription factor ICP4 homolog

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03309 super family cl29689
transcriptional regulator ICP4; Provisional
 1-2033 0e+00

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03309:

Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 3532.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336     1 MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGF 80
Cdd:PHA03309    1 MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336    81 CSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSS 160
Cdd:PHA03309   81 CSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   161 SPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRC 240
Cdd:PHA03309  161 SPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   241 ETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAAR 320
Cdd:PHA03309  241 ETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAAR 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   321 RSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRG 400
Cdd:PHA03309  321 RSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRG 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   401 MRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHA 480
Cdd:PHA03309  401 MRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHA 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   481 EEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKML 560
Cdd:PHA03309  481 EEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKML 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   561 NLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYY 640
Cdd:PHA03309  561 NLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYY 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   641 GKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLP 720
Cdd:PHA03309  641 GKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLP 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   721 PDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAP 800
Cdd:PHA03309  721 PDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAP 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   801 LVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVG 880
Cdd:PHA03309  801 LVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVG 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   881 ASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLS 960
Cdd:PHA03309  881 ASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLS 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   961 VTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTP 1040
Cdd:PHA03309  961 VTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTP 1040

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1041 ASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDG 1120
Cdd:PHA03309 1041 ASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDG 1120

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1121 LAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRL 1200
Cdd:PHA03309 1121 LAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRL 1200

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1201 AEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAAL 1280
Cdd:PHA03309 1201 AEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAAL 1280

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1281 AGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESML 1360
Cdd:PHA03309 1281 AGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESML 1360

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1361 RRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEG 1440
Cdd:PHA03309 1361 RRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEG 1440

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1441 TPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGW 1520
Cdd:PHA03309 1441 TPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGW 1520

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1521 GHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRR 1600
Cdd:PHA03309 1521 GHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRR 1600

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1601 MSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPT 1680
Cdd:PHA03309 1601 MSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPT 1680

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1681 PRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRR 1760
Cdd:PHA03309 1681 PRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRR 1760

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1761 FGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSAT 1840
Cdd:PHA03309 1761 FGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSAT 1840

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1841 PSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLP 1920
Cdd:PHA03309 1841 PSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLP 1920

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1921 SRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHT 2000
Cdd:PHA03309 1921 SRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHT 2000

                        2010      2020      2030
                  ....*....|....*....|....*....|...
gi 81987336  2001 DVSAASAFFLGRPAPGSCGRRPLGARVRGGTER 2033
Cdd:PHA03309 2001 DVSAASAFFLGRPAPGSCGRRPLGARVRGGTER 2033
 
Name Accession Description Interval E-value
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 1-2033 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 3532.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336     1 MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGF 80
Cdd:PHA03309    1 MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336    81 CSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSS 160
Cdd:PHA03309   81 CSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   161 SPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRC 240
Cdd:PHA03309  161 SPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   241 ETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAAR 320
Cdd:PHA03309  241 ETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAAR 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   321 RSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRG 400
Cdd:PHA03309  321 RSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRG 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   401 MRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHA 480
Cdd:PHA03309  401 MRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHA 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   481 EEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKML 560
Cdd:PHA03309  481 EEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKML 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   561 NLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYY 640
Cdd:PHA03309  561 NLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYY 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   641 GKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLP 720
Cdd:PHA03309  641 GKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLP 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   721 PDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAP 800
Cdd:PHA03309  721 PDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAP 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   801 LVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVG 880
Cdd:PHA03309  801 LVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVG 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   881 ASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLS 960
Cdd:PHA03309  881 ASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLS 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   961 VTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTP 1040
Cdd:PHA03309  961 VTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTP 1040

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1041 ASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDG 1120
Cdd:PHA03309 1041 ASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDG 1120

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1121 LAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRL 1200
Cdd:PHA03309 1121 LAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRL 1200

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1201 AEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAAL 1280
Cdd:PHA03309 1201 AEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAAL 1280

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1281 AGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESML 1360
Cdd:PHA03309 1281 AGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESML 1360

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1361 RRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEG 1440
Cdd:PHA03309 1361 RRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEG 1440

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1441 TPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGW 1520
Cdd:PHA03309 1441 TPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGW 1520

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1521 GHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRR 1600
Cdd:PHA03309 1521 GHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRR 1600

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1601 MSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPT 1680
Cdd:PHA03309 1601 MSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPT 1680

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1681 PRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRR 1760
Cdd:PHA03309 1681 PRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRR 1760

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1761 FGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSAT 1840
Cdd:PHA03309 1761 FGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSAT 1840

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1841 PSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLP 1920
Cdd:PHA03309 1841 PSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLP 1920

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1921 SRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHT 2000
Cdd:PHA03309 1921 SRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHT 2000

                        2010      2020      2030
                  ....*....|....*....|....*....|...
gi 81987336  2001 DVSAASAFFLGRPAPGSCGRRPLGARVRGGTER 2033
Cdd:PHA03309 2001 DVSAASAFFLGRPAPGSCGRRPLGARVRGGTER 2033
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 632-807 1.83e-58

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 199.28  E-value: 1.83e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336    632 PPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFM---LQPLSRVSHSyggsRL 707
Cdd:pfam03584    1 PPPPGRVLYGGLGdSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYtpdAEPLGWLQNP----RL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336    708 NKTEKNLCKICLPpdggddrdgggksRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQK 787
Cdd:pfam03584   77 NPGDVALNQICQK-------------ISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQK 143

                          170       180
                   ....*....|....*....|
gi 81987336    788 TYLLSCLRLAFAPLVFPGAS 807
Cdd:pfam03584  144 TFLLTSLRRAYAPLAFPENA 163
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 895-1405 5.01e-06

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 51.80  E-value: 5.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  895 FLRGVTERREDLFSAARRCPRAL--YSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLSVTSVPDGGDVRY 972
Cdd:COG3321  841 WVAGVPVDWSALYPGRGRRRVPLptYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALA 920

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  973 AFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTPASRPPHGSAAAP 1052
Cdd:COG3321  921 LAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAA 1000

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1053 PSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDeAGTDDDGDAPVVISYVGPSSPPGVEDPSPDGLAALRPLPEGYV 1132
Cdd:COG3321 1001 ALALLAAAALLLAAAAAAAALLALAALLAAAAAALA-AAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELAL 1079

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1133 PRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRLAEHLQSDDGWTR 1212
Cdd:COG3321 1080 AAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAAL 1159

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1213 AFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAALAGRACVPGSACD 1292
Cdd:COG3321 1160 AAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALA 1239

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1293 PETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESMLRRALSRQGQACA 1372
Cdd:COG3321 1240 AAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAA 1319

                        490       500       510
                 ....*....|....*....|....*....|...
gi 81987336 1373 VVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPP 1405
Cdd:COG3321 1320 ALAAALLAAALAALAAAVAAALALAAAAAAAAA 1352
 
Name Accession Description Interval E-value
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 1-2033 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 3532.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336     1 MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGF 80
Cdd:PHA03309    1 MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336    81 CSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSS 160
Cdd:PHA03309   81 CSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   161 SPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRC 240
Cdd:PHA03309  161 SPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   241 ETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAAR 320
Cdd:PHA03309  241 ETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAAR 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   321 RSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRG 400
Cdd:PHA03309  321 RSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRG 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   401 MRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHA 480
Cdd:PHA03309  401 MRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHA 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   481 EEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKML 560
Cdd:PHA03309  481 EEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKML 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   561 NLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYY 640
Cdd:PHA03309  561 NLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYY 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   641 GKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLP 720
Cdd:PHA03309  641 GKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLP 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   721 PDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAP 800
Cdd:PHA03309  721 PDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAP 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   801 LVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVG 880
Cdd:PHA03309  801 LVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVG 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   881 ASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLS 960
Cdd:PHA03309  881 ASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLS 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   961 VTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTP 1040
Cdd:PHA03309  961 VTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTP 1040

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1041 ASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDG 1120
Cdd:PHA03309 1041 ASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDG 1120

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1121 LAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRL 1200
Cdd:PHA03309 1121 LAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRL 1200

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1201 AEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAAL 1280
Cdd:PHA03309 1201 AEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAAL 1280

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1281 AGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESML 1360
Cdd:PHA03309 1281 AGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESML 1360

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1361 RRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEG 1440
Cdd:PHA03309 1361 RRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEG 1440

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1441 TPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGW 1520
Cdd:PHA03309 1441 TPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGW 1520

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1521 GHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRR 1600
Cdd:PHA03309 1521 GHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRR 1600

                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1601 MSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPT 1680
Cdd:PHA03309 1601 MSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPT 1680

                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1681 PRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRR 1760
Cdd:PHA03309 1681 PRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRR 1760

                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1761 FGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSAT 1840
Cdd:PHA03309 1761 FGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSAT 1840

                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1841 PSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLP 1920
Cdd:PHA03309 1841 PSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLP 1920

                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1921 SRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHT 2000
Cdd:PHA03309 1921 SRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHT 2000

                        2010      2020      2030
                  ....*....|....*....|....*....|...
gi 81987336  2001 DVSAASAFFLGRPAPGSCGRRPLGARVRGGTER 2033
Cdd:PHA03309 2001 DVSAASAFFLGRPAPGSCGRRPLGARVRGGTER 2033
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 520-1554 1.19e-111

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 391.48  E-value: 1.19e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   520 RNKPARQRLRAGAIVAAASGN----TLTVPSEPPHPSLAPLWKMLNLWLseewpaqgggQDEGEAAVSASLLAPgslPEL 595
Cdd:PHA03308  255 RGRLARRLESAGSEKSTESPDrdsaQLVLPGECPDVALEPLWRVLREWV----------ETDGTDGSVQSVTAP---TEL 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   596 PDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYYGkTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEE 675
Cdd:PHA03308  322 PDLGRGITLNVLSRALAVDLHSSEARVFVPEAIIPSPPSRGQVYHG-SGYRQSLVDDPQVREAAAEFHANPKSASVYLEE 400

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   676 FGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKIClppdggddrdgggkSRGGRGGGSKDASRTAMATGVPH 755
Cdd:PHA03308  401 YGMPVEQLERLVEEFMVHPLSRVSYGYGGPKLSPRDKRLCELC--------------ALRGPGSSEGGLSRSAVPTCLPH 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   756 IVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAPLVFPGAS-PPVGADDSpwPTSPIRECAAALREGFR 834
Cdd:PHA03308  467 VAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAALRRAFVPFVFPGAAvDPTAASAS--GDHPVLVGARRIARATR 544

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   835 ALNdiRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVGASVVHDGrvglPAfflrgvtERREDLFSAARRCP 914
Cdd:PHA03308  545 ELE--AAAKEPPAATPEKLSSSALLRHTRTCIVAAADLMAALTAIDCPPVTIN----PA-------KRRPDLYQALSRAP 611

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   915 RALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLSVTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVR 994
Cdd:PHA03308  612 KTVFTWERAMPYCAASLWSRLVIGSLPLPSTDDVTLLVEAMEAAVGVLGCSDEGDVRPSIAYAASGWRMIATMLGDDSAP 691

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   995 TSSGESGDAETD-----------------AAYALLAPGKQSSAGVNHPRGRPGRATASSPRTPASRPPHGSAAAPPSGRD 1057
Cdd:PHA03308  692 GSEHVTDDCPADddthhhdrrkrrggrrtTCRYDLPPGTPDRAAHLLLYGSPGGGDGAEPSAAQESPANPWPRAPPCDEQ 771

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1058 SPPGAL------NVPEAAEEELRLAAARDTTGDlLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDG--LAALRPLPE 1129
Cdd:PHA03308  772 EPLSVSpygpepDRPPDDDFETRKGLKRKSSED-HADPIPEGNATKKTCGLQGLPDSLPPAVPETDRDNplLPPCPITPE 850

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1130 GYVPRPgdvlRGDPGADENDDDARAP----CRVGDA-------SP----------PRQLPSSSSFASSSLASAVPGDPYL 1188
Cdd:PHA03308  851 GPPCPP----REEPQQPQEPQEPQSPsfhiSEIGEAlfhstpvSPtilfapegfiPNQGDVYRPHGKNLGVALSAGEPYV 926

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1189 PRSVAEPTLCRLAEHLQSDDG-------------WTRAFANDPVGLAEFARRSTPGRRlGGQRRLDQLLSWTRRHSPRRR 1255
Cdd:PHA03308  927 PAHRARPALERLANYLRGLSSgpagsysatgpadWLPAFARDPVALGEFCKRISPVNR-GGRCVLEERLSWTLRHPADKI 1005

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1256 YSLIVLVSEKRPGDFRERAYAAAALAGRACVPGSACDPETWRDAEdHPSPSADAQSPLRSrpsrdcfppriaqpeasddd 1335
Cdd:PHA03308 1006 YDLIILVSERAPGEFLERAYAYAALCGRACMPGGACWPESWTRGE-YPYIPPDEKDPGRS-------------------- 1064

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1336 dvgeggTALLSAGDIGFAGAVESMLRRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPS 1415
Cdd:PHA03308 1065 ------VAILCTTDLGYAGAVEWMLERALSTSGRACVVVDARDPGDEDSRSGPRIPTGRRGVVYARTSPPSHAYLVKLFT 1138

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1416 lGPSASP-HRG---VGGKHRDKRPCLAEGTPSAPSCRDAARATAPLSGDPVAHrllmhrpakplvgeeacaallggkagr 1491
Cdd:PHA03308 1139 -GPAAERlERGglnVGHVVMDRRLTVSWPLSVGKTDNDDEGTGDREKCPPVKH--------------------------- 1190

                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 81987336  1492 rgqdvplPFLTAATLRKVARVARELDPGWGHGDLGCESAVVFP---------PAAPPGPELADRHADRRRST 1554
Cdd:PHA03308 1191 -------PFLTHVTLRRLRDVARAMDAGWSHSEIGKASAVLYPymaqphvgaGAMPPCPDLSESSSTMHSSS 1255
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 632-807 1.83e-58

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 199.28  E-value: 1.83e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336    632 PPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFM---LQPLSRVSHSyggsRL 707
Cdd:pfam03584    1 PPPPGRVLYGGLGdSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYtpdAEPLGWLQNP----RL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336    708 NKTEKNLCKICLPpdggddrdgggksRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQK 787
Cdd:pfam03584   77 NPGDVALNQICQK-------------ISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQK 143

                          170       180
                   ....*....|....*....|
gi 81987336    788 TYLLSCLRLAFAPLVFPGAS 807
Cdd:pfam03584  144 TFLLTSLRRAYAPLAFPENA 163
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 632-1238 9.46e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 70.59  E-value: 9.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   632 PPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVaEFMLQPLSRVSHSYGGSRLNKT 710
Cdd:PHA03307  445 PPPPGRVRYGGLGdSRPGLWDAPEVREAAARYEASPGPVPVYVPEMGDSAKQYAALV-RLLYTPDREAMGWLQNPKLTGP 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   711 EKNLCKIClppdggddrdgggKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYL 790
Cdd:PHA03307  524 DQALDQFC-------------QKKFQAPRGSGSFITGSVARPVPHIGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFL 590

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   791 LSCLRLAFAPLVFPGASPPVGADdspwptspirecaaALREGFRALNDIRAEQDPPADERSRELAlpldraitaaRRVAA 870
Cdd:PHA03307  591 LQSLRRAYAPMAYPENAADTGAG--------------AAAPAPAAPRPDAAAAGGASARPLRELA----------DACVL 646

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   871 TAAGLLNAVGASVVHDGRVGLPAFFLRGVTERredlfsAARRCPRALYSWERSMRATTAALWGHLASRGPIAApvADLEE 950
Cdd:PHA03307  647 ACRAVLEALLEGPDGLSAVPGLAFPRPACPPR------ALEACPARLESWLRELRDLRDAVYLARLRGDLPVA--GGREE 718

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   951 LSQALSAVLSVTSVPdGGDVRYAfaeADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRgRPG 1030
Cdd:PHA03307  719 RVAAVRAVSLVARTV-APLVRYS---PRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQRGAGSSPPV-RAE 793

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1031 RATASSPRTPASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAArdttgdlLSDEAGTDDDGDAPVVISYVGPSSP 1110
Cdd:PHA03307  794 AAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARPPGA-------AARPPPARSSESSKSKPAAAGGRAR 866

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1111 PGVEDPSPDGLAALRPLPEGyVPRPGDVLRGDPGADENDDDARAPCRVGdASPPRQLPSSSS---FASSSLASAVPGDPY 1187
Cdd:PHA03307  867 GKNGRRRPRPPEPRARPGAA-APPKAAAAAPPAGAPAPRPRPAPRVKLG-PMPPGGPDPRGGfrrVPPGDLHTPAPSAAA 944

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 81987336  1188 L-----PRSVAEptlcrLAEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQR 1238
Cdd:PHA03307  945 LaaycpPEVVAE-----LVDHPLFPEPWRPALAFDPEALAEIAARCGGPPPRSGSA 995
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 895-1405 5.01e-06

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 51.80  E-value: 5.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  895 FLRGVTERREDLFSAARRCPRAL--YSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLSVTSVPDGGDVRY 972
Cdd:COG3321  841 WVAGVPVDWSALYPGRGRRRVPLptYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALA 920

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  973 AFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTPASRPPHGSAAAP 1052
Cdd:COG3321  921 LAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAA 1000

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1053 PSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDeAGTDDDGDAPVVISYVGPSSPPGVEDPSPDGLAALRPLPEGYV 1132
Cdd:COG3321 1001 ALALLAAAALLLAAAAAAAALLALAALLAAAAAALA-AAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELAL 1079

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1133 PRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRLAEHLQSDDGWTR 1212
Cdd:COG3321 1080 AAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAAL 1159

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1213 AFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAALAGRACVPGSACD 1292
Cdd:COG3321 1160 AAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALA 1239

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336 1293 PETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESMLRRALSRQGQACA 1372
Cdd:COG3321 1240 AAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAAA 1319

                        490       500       510
                 ....*....|....*....|....*....|...
gi 81987336 1373 VVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPP 1405
Cdd:COG3321 1320 ALAAALLAAALAALAAAVAAALALAAAAAAAAA 1352
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 989-1155 3.58e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336   989 GGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVnhPRGRPGRATASSPRTPASRPPHGSAAAPPSGRDSPPGALNVPEA 1068
Cdd:PRK07764  629 PAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA--SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPA 706

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81987336  1069 AEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDGLAALRPLPEGYVPRPGDVLRGDPGADEN 1148
Cdd:PRK07764  707 ATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMA 786


                  ....*..
gi 81987336  1149 DDDARAP 1155
Cdd:PRK07764  787 EDDAPSM 793
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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