NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|82654948|sp|P07744|]
View 

RecName: Full=Keratin, type II cytoskeletal 4; AltName: Full=Cytokeratin-4; Short=CK-4; AltName: Full=Cytoskeletal 57 kDa keratin; AltName: Full=Keratin-4; Short=K4; AltName: Full=Type-II keratin Kb4

Protein Classification

type II keratin( domain architecture ID 12177255)

type II keratin is an intermediate filament-forming protein that provides mechanical support and fulfills a variety of additional functions in epithelial cells

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
146-458 3.14e-148

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 427.41  E-value: 3.14e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   146 EREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQTTTtSPKSLDPFFETYINALRKNLDTLSNDKGRLQSELKMM 225
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   226 QDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINFTRVLYEAELAQMQTHVSDTSVVLSM 305
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   306 DNNRNLDLDGIIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQS 385
Cdd:pfam00038 161 DAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82654948   386 QTLQASVADAEQRGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLEGEECR 458
Cdd:pfam00038 241 ASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Keratin_2_head pfam16208
Keratin type II head;
14-142 2.12e-27

Keratin type II head;


:

Pssm-ID: 465068 [Multi-domain]  Cd Length: 156  Bit Score: 107.82  E-value: 2.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    14 GFSSGSAIAGGVKRVAFSSGSM------SGGAGRCSSGGFGSRSLYNLGGHKSISMSVAGSCQGGGYGGAGGFGVGGYGA 87
Cdd:pfam16208   1 GFSSCSAVVPSRSRRSYSSVSSsrrgggGGGGGGGGGGGFGSRSLYNLGGSKSISISVAGGGSRPGSGFGFGGGGGGGFG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 82654948    88 GFGAGGFGGGFGGSFNG---------------------RGGPGFPVCPAGGIQEVTINQSLLTPLQVEIDPEIQKI 142
Cdd:pfam16208  81 GGFGGGGGGGFGGGGGFgggfggggyggggfggggfggRGGFGGPPCPPGGIQEVTVNQSLLQPLNLEIDPEIQRV 156
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
146-458 3.14e-148

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 427.41  E-value: 3.14e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   146 EREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQTTTtSPKSLDPFFETYINALRKNLDTLSNDKGRLQSELKMM 225
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   226 QDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINFTRVLYEAELAQMQTHVSDTSVVLSM 305
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   306 DNNRNLDLDGIIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQS 385
Cdd:pfam00038 161 DAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82654948   386 QTLQASVADAEQRGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLEGEECR 458
Cdd:pfam00038 241 ASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Keratin_2_head pfam16208
Keratin type II head;
14-142 2.12e-27

Keratin type II head;


Pssm-ID: 465068 [Multi-domain]  Cd Length: 156  Bit Score: 107.82  E-value: 2.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    14 GFSSGSAIAGGVKRVAFSSGSM------SGGAGRCSSGGFGSRSLYNLGGHKSISMSVAGSCQGGGYGGAGGFGVGGYGA 87
Cdd:pfam16208   1 GFSSCSAVVPSRSRRSYSSVSSsrrgggGGGGGGGGGGGFGSRSLYNLGGSKSISISVAGGGSRPGSGFGFGGGGGGGFG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 82654948    88 GFGAGGFGGGFGGSFNG---------------------RGGPGFPVCPAGGIQEVTINQSLLTPLQVEIDPEIQKI 142
Cdd:pfam16208  81 GGFGGGGGGGFGGGGGFgggfggggyggggfggggfggRGGFGGPPCPPGGIQEVTVNQSLLQPLNLEIDPEIQRV 156
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 144-427 4.75e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.83  E-value: 4.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    144 TAEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLqqqttttspKSLDPFFETYINALRKNLDTLSNDKGRLQSELK 223
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQELEEKLEEL---------RLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    224 MMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEInftrvlyEAELAQMQthvsdtsvvl 303
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL-------EELEAELE---------- 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    304 smdnnrnlDLDGIIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQH--GDSLKTTKNEISELNRMIQR-----LRA 376
Cdd:TIGR02168  369 --------ELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLErlEDRRERLQQEIEELLKKLEEaelkeLQA 440

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 82654948    377 EIENIKKQSQTLQASVADAEQRGELALKdaysKRAELETALQKAKEDLARL 427
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELRE----ELEEAEQALDAAERELAQL 487
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 201-456 5.49e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 5.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 201 INALRKNLDTLSNDKGRLQSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINf 280
Cdd:COG1196 255 LEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE- 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 281 trvLYEAELAQMQTHVSDTSVVLSMDNNRnldldgiIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQhgdslKTT 360
Cdd:COG1196 334 ---ELEEELEELEEELEEAEEELEEAEAE-------LAEAEEALLEAEAELAEAEEELEELAEELLEALRAA-----AEL 398

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 361 KNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQ---RGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNV 437
Cdd:COG1196 399 AAQLEELEEAEEALLERLERLEEELEELEEALAELEEeeeEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAA 478

                       250
                ....*....|....*....
gi 82654948 438 KLALDVEIATYRKLLEGEE 456
Cdd:COG1196 479 LAELLEELAEAAARLLLLL 497
46 PHA02562
endonuclease subunit; Provisional
 162-414 4.12e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 49.24  E-value: 4.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  162 DKVRFLEQQNKVLETKWNLLQQQTTTtspksldpfFETYINALRKnldtLSNDKgrlQSELKMMQDSVEDFKTKYEEEIN 241
Cdd:PHA02562 174 DKIRELNQQIQTLDMKIDHIQQQIKT---------YNKNIEEQRK----KNGEN---IARKQNKYDELVEEAKTIKAEIE 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  242 KRTAAENDFVVLKKDVDAAY----MIKVELEAKMESLKDEINFTRVLYEAElAQMQThvsdtsvvLSMDNNRNLDLDGII 317
Cdd:PHA02562 238 ELTDELLNLVMDIEDPSAALnklnTAAAKIKSKIEQFQKVIKMYEKGGVCP-TCTQQ--------ISEGPDRITKIKDKL 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  318 AEVRAQYEDIarkskaeveswyQIKVQQLQMSADQHGD---SLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVAD 394
Cdd:PHA02562 309 KELQHSLEKL------------DTAIDELEEIMDEFNEqskKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVD 376

                        250       260
                 ....*....|....*....|....*
gi 82654948  395 AEqrGELA-----LKDAYSKRAELE 414
Cdd:PHA02562 377 NA--EELAklqdeLDKIVKTKSELV 399
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
146-458 3.14e-148

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 427.41  E-value: 3.14e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   146 EREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQTTTtSPKSLDPFFETYINALRKNLDTLSNDKGRLQSELKMM 225
Cdd:pfam00038   2 EKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   226 QDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINFTRVLYEAELAQMQTHVSDTSVVLSM 305
Cdd:pfam00038  81 RLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEEEVRELQAQVSDTQVNVEM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   306 DNNRNLDLDGIIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQS 385
Cdd:pfam00038 161 DAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82654948   386 QTLQASVADAEQRGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLEGEECR 458
Cdd:pfam00038 241 ASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEECR 313
Keratin_2_head pfam16208
Keratin type II head;
14-142 2.12e-27

Keratin type II head;


Pssm-ID: 465068 [Multi-domain]  Cd Length: 156  Bit Score: 107.82  E-value: 2.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    14 GFSSGSAIAGGVKRVAFSSGSM------SGGAGRCSSGGFGSRSLYNLGGHKSISMSVAGSCQGGGYGGAGGFGVGGYGA 87
Cdd:pfam16208   1 GFSSCSAVVPSRSRRSYSSVSSsrrgggGGGGGGGGGGGFGSRSLYNLGGSKSISISVAGGGSRPGSGFGFGGGGGGGFG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 82654948    88 GFGAGGFGGGFGGSFNG---------------------RGGPGFPVCPAGGIQEVTINQSLLTPLQVEIDPEIQKI 142
Cdd:pfam16208  81 GGFGGGGGGGFGGGGGFgggfggggyggggfggggfggRGGFGGPPCPPGGIQEVTVNQSLLQPLNLEIDPEIQRV 156
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 144-427 4.75e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.83  E-value: 4.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    144 TAEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLqqqttttspKSLDPFFETYINALRKNLDTLSNDKGRLQSELK 223
Cdd:TIGR02168  235 EELREELEELQEELKEAEEELEELTAELQELEEKLEEL---------RLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    224 MMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEInftrvlyEAELAQMQthvsdtsvvl 303
Cdd:TIGR02168  306 ILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL-------EELEAELE---------- 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    304 smdnnrnlDLDGIIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQH--GDSLKTTKNEISELNRMIQR-----LRA 376
Cdd:TIGR02168  369 --------ELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLErlEDRRERLQQEIEELLKKLEEaelkeLQA 440

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 82654948    377 EIENIKKQSQTLQASVADAEQRGELALKdaysKRAELETALQKAKEDLARL 427
Cdd:TIGR02168  441 ELEELEEELEELQEELERLEEALEELRE----ELEEAEQALDAAERELAQL 487
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 201-456 5.49e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 5.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 201 INALRKNLDTLSNDKGRLQSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINf 280
Cdd:COG1196 255 LEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE- 333

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 281 trvLYEAELAQMQTHVSDTSVVLSMDNNRnldldgiIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQhgdslKTT 360
Cdd:COG1196 334 ---ELEEELEELEEELEEAEEELEEAEAE-------LAEAEEALLEAEAELAEAEEELEELAEELLEALRAA-----AEL 398

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 361 KNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQ---RGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNV 437
Cdd:COG1196 399 AAQLEELEEAEEALLERLERLEEELEELEEALAELEEeeeEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAA 478

                       250
                ....*....|....*....
gi 82654948 438 KLALDVEIATYRKLLEGEE 456
Cdd:COG1196 479 LAELLEELAEAAARLLLLL 497
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 313-450 7.69e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 7.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    313 LDGIIAEVRAQYEDIARKSKAEVESWYQIKVQQLQMSADQHG--DSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQA 390
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEElqKELYALANEISRLEQQKQILRERLANLERQLEELEA 323

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82654948    391 SVADAEQRGELALKDAYSKRAELETALQK---AKEDLARLLRDYQALMNVKLALDVEIATYRK 450
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEElesLEAELEELEAELEELESRLEELEEQLETLRS 386
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 217-453 3.11e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 3.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    217 RLQSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINftrvlyeaELAQMQTHV 296
Cdd:TIGR02168  681 ELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE--------QLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    297 SDTsvvlsmdnnrNLDLDGIIAEVRAQYEDiARKSKAEVESwyqiKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRA 376
Cdd:TIGR02168  753 SKE----------LTELEAEIEELEERLEE-AEEELAEAEA----EIEELEAQIEQLKEELKALREALDELRAELTLLNE 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    377 EIENIKKQSQTLQASVADAEQRGELA---LKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLE 453
Cdd:TIGR02168  818 EAANLRERLESLERRIAATERRLEDLeeqIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE 897
46 PHA02562
endonuclease subunit; Provisional
 162-414 4.12e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 49.24  E-value: 4.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  162 DKVRFLEQQNKVLETKWNLLQQQTTTtspksldpfFETYINALRKnldtLSNDKgrlQSELKMMQDSVEDFKTKYEEEIN 241
Cdd:PHA02562 174 DKIRELNQQIQTLDMKIDHIQQQIKT---------YNKNIEEQRK----KNGEN---IARKQNKYDELVEEAKTIKAEIE 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  242 KRTAAENDFVVLKKDVDAAY----MIKVELEAKMESLKDEINFTRVLYEAElAQMQThvsdtsvvLSMDNNRNLDLDGII 317
Cdd:PHA02562 238 ELTDELLNLVMDIEDPSAALnklnTAAAKIKSKIEQFQKVIKMYEKGGVCP-TCTQQ--------ISEGPDRITKIKDKL 308

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  318 AEVRAQYEDIarkskaeveswyQIKVQQLQMSADQHGD---SLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVAD 394
Cdd:PHA02562 309 KELQHSLEKL------------DTAIDELEEIMDEFNEqskKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVD 376

                        250       260
                 ....*....|....*....|....*
gi 82654948  395 AEqrGELA-----LKDAYSKRAELE 414
Cdd:PHA02562 377 NA--EELAklqdeLDKIVKTKSELV 399
PRK01156 PRK01156
chromosome segregation protein; Provisional
 134-456 1.36e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 47.97  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  134 EIDPEIQKIRTAE-REQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQT------TTTSPKSLDPFFETY---INA 203
Cdd:PRK01156 401 EIDPDAIKKELNEiNVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSvcpvcgTTLGEEKSNHIINHYnekKSR 480

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  204 LRKNLDTLSNDKGRLQSE---LKMMQDSVEDFKT-KYEEEINKRTAAENDfvvLKKDVDAAYMIKvELEAKMESLKDEIN 279
Cdd:PRK01156 481 LEEKIREIEIEVKDIDEKivdLKKRKEYLESEEInKSINEYNKIESARAD---LEDIKIKINELK-DKHDKYEEIKNRYK 556

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  280 FTRVlyeAELAQMQTHVSDTSVVLSmdnnrNLDLDGIIA---EVRAQYEDIARKSK------AEVESWYQIKVQQLqmsa 350
Cdd:PRK01156 557 SLKL---EDLDSKRTSWLNALAVIS-----LIDIETNRSrsnEIKKQLNDLESRLQeieigfPDDKSYIDKSIREI---- 624

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  351 DQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQaSVADAEQRGELALKDAYSKRAELETALQKAKEDLARLLRD 430
Cdd:PRK01156 625 ENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEID-SIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLEST 703

                        330       340
                 ....*....|....*....|....*.
gi 82654948  431 YQALMNVKLALDVEIATYRKLLEGEE 456
Cdd:PRK01156 704 IEILRTRINELSDRINDINETLESMK 729
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
266-436 4.04e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.45  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  266 ELEAKMESLKDEINFTRVLYE---AELAQMQTHVSDTSVVLSMDNNRnLDLDGI---IAEVRAQYEDIaRKSKAEVEswy 339
Cdd:COG4913  614 ALEAELAELEEELAEAEERLEaleAELDALQERREALQRLAEYSWDE-IDVASAereIAELEAELERL-DASSDDLA--- 688

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  340 qikvqQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQRGELALK---DAYSKRAELETA 416
Cdd:COG4913  689 -----ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRallEERFAAALGDAV 763

                        170       180
                 ....*....|....*....|
gi 82654948  417 LQKAKEDLARLLRDYQALMN 436
Cdd:COG4913  764 ERELRENLEERIDALRARLN 783
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
191-453 1.09e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  191 KSLDPFFETY----------INALRKNLDTLSndkgRLQSELKMMQDSVE---DFKTKYEE-EINKRTAAENDFVVLKKD 256
Cdd:COG4913  207 GDLDDFVREYmleepdtfeaADALVEHFDDLE----RAHEALEDAREQIEllePIRELAERyAAARERLAELEYLRAALR 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  257 VDAAYMIKVELEAKMESLKDEINFTrvlyEAELAQMQTHVSDtsvvlsmdnnrnldLDGIIAEVRAQYEDIArkskaeve 336
Cdd:COG4913  283 LWFAQRRLELLEAELEELRAELARL----EAELERLEARLDA--------------LREELDELEAQIRGNG-------- 336

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  337 swyQIKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQRGELALKDAYSKRAELETA 416
Cdd:COG4913  337 ---GDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 82654948  417 LQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLE 453
Cdd:COG4913  414 LRDLRRELRELEAEIASLERRKSNIPARLLALRDALA 450
PRK09039 PRK09039
peptidoglycan -binding protein;
286-426 3.41e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.03  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  286 EAELAQMQTHVSDTSVVLSMDNNRNLDLDGIIAEVRAQYEDiARKSKAEVESWYQIKVQQLQMSADQHGD---SLKTTKN 362
Cdd:PRK09039  52 DSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSA-AEAERSRLQALLAELAGAGAAAEGRAGElaqELDSEKQ 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 82654948  363 EISELNRMIQRLRAEIENIKKQSQTLQASVADAEQRGELALKDAYSKRAELETALQKAKEDLAR 426
Cdd:PRK09039 131 VSARALAQVELLNQQIAALRRQLAALEAALDASEKRDRESQAKIADLGRRLNVALAQRVQELNR 194
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
198-449 4.14e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 4.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 198 ETYINALRKNLDTLSNDKGRLQSELKMMQDSVEDFKtkyeeeinkrtaAENDFVVLKKDVDAAYMIKVELEAKMESLKDE 277
Cdd:COG3206 167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------------QKNGLVDLSEEAKLLLQQLSELESQLAEARAE 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 278 INFTRVLYEAELAQMQTHVSDTSVVLsmDNNRNLDLDGIIAEVRAQYEDIARKSKAEveswyQIKVQQLQmsadqhgDSL 357
Cdd:COG3206 235 LAEAEARLAALRAQLGSGPDALPELL--QSPVIQQLRAQLAELEAELAELSARYTPN-----HPDVIALR-------AQI 300

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 358 KTTKNEI-SELNRMIQRLRAEIENIKKQSQTLQASVADAEQRGeLALKDAYSKRAELETALQKAKEDLARLLRDYQALmn 436
Cdd:COG3206 301 AALRAQLqQEAQRILASLEAELEALQAREASLQAQLAQLEARL-AELPELEAELRRLEREVEVARELYESLLQRLEEA-- 377

                       250
                ....*....|...
gi 82654948 437 vKLALDVEIATYR 449
Cdd:COG3206 378 -RLAEALTVGNVR 389
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 203-450 5.09e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.44  E-value: 5.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 203 ALRKNLDTLSNDKGRLQSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINFTR 282
Cdd:COG4942  17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 283 vlyeAELAQMQTHVSDTSVVLSMdNNRNLDLDGIIAevRAQYEDIARKSKaevesWYQIKVQQLQmsadQHGDSLKTTKN 362
Cdd:COG4942  97 ----AELEAQKEELAELLRALYR-LGRQPPLALLLS--PEDFLDAVRRLQ-----YLKYLAPARR----EQAEELRADLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 363 EIselnrmiQRLRAEIENIKKQSQTLQASVADAEQRGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLALD 442
Cdd:COG4942 161 EL-------AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE 233


                ....*...
gi 82654948 443 VEIATYRK 450
Cdd:COG4942 234 AEAAAAAE 241
PRK01156 PRK01156
chromosome segregation protein; Provisional
 138-427 5.45e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 42.97  E-value: 5.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  138 EIQKIRTAEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQttttspksldpffetyINALRKNLDTLSNDKGR 217
Cdd:PRK01156 173 DVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKE----------------IERLSIEYNNAMDDYNN 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  218 LQSELKMMQdSVEDFKTKYEEEINKrtaaendfvvLKKDVDAAYMIKVELEAKMESLKDEINFTRVLYEAELAQMQTHVS 297
Cdd:PRK01156 237 LKSALNELS-SLEDMKNRYESEIKT----------AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKN 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  298 DtsvvlsMDNNRNLdLDGIIAEVRaQYEDIARKSkAEVESWYQ--IKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLR 375
Cdd:PRK01156 306 D------IENKKQI-LSNIDAEIN-KYHAIIKKL-SVLQKDYNdyIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLK 376

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 82654948  376 AEIENIKKQSQTLQASVADAEQRGELALKDAYSKRAELETALQKAKEDLARL 427
Cdd:PRK01156 377 KKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSL 428
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 201-434 5.84e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 42.80  E-value: 5.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    201 INALRKNLDTLSNDKGRLQSELKMMQDSVE----------DFKTKYEEEINKRTAA-ENDFVVLKKDVDAAYMIKVELEA 269
Cdd:pfam15921  414 IDHLRRELDDRNMEVQRLEALLKAMKSECQgqmerqmaaiQGKNESLEKVSSLTAQlESTKEMLRKVVEELTAKKMTLES 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    270 KMESLKDeinFTRVLYEAELAQMQTHVSDTSVVLSMD---------NNRNLDLDGIIAEVRAQYEDIARKSKAeVESWYQ 340
Cdd:pfam15921  494 SERTVSD---LTASLQEKERAIEATNAEITKLRSRVDlklqelqhlKNEGDHLRNVQTECEALKLQMAEKDKV-IEILRQ 569

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    341 iKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIK-------KQSQTLQASVADAE-QRGEL---------AL 403
Cdd:pfam15921  570 -QIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKilkdkkdAKIRELEARVSDLElEKVKLvnagserlrAV 648

                          250       260       270
                   ....*....|....*....|....*....|.
gi 82654948    404 KDAYSKRAELETALQKAKEDLARLLRDYQAL 434
Cdd:pfam15921  649 KDIKQERDQLLNEVKTSRNELNSLSEDYEVL 679
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 317-470 8.68e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 8.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    317 IAEVRAQYEDIARK---SKAEVESwYQIKVQQLQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVA 393
Cdd:TIGR02168  679 IEELEEKIEELEEKiaeLEKALAE-LRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELT 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    394 DAEQR----------GELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLEGEECRMSGEC 463
Cdd:TIGR02168  758 ELEAEieeleerleeAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATE 837


                   ....*..
gi 82654948    464 KSAVSIS 470
Cdd:TIGR02168  838 RRLEDLE 844
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 125-440 1.07e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    125 QSLLTPLQVEIDPEIQKIRtAEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQTTTTSPKSLDPffETYINAL 204
Cdd:TIGR02168  711 EEELEQLRKELEELSRQIS-ALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA--EAEIEEL 787

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    205 RKNLDTLSNDKGRLQSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYMIKVELEAKMESLKDEINFTRVL 284
Cdd:TIGR02168  788 EAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEEL 867

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    285 YEAELAQmqthvsdtsvvlsmdnnrnldLDGIIAEVRAQYEDIARKSKAEveswyqikvQQLQMSADQHGDSLKTTKNEI 364
Cdd:TIGR02168  868 IEELESE---------------------LEALLNERASLEEALALLRSEL---------EELSEELRELESKRSELRREL 917

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 82654948    365 SELNRMIQRLRAEIENIKKQSQTLQASVADaeqRGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNVKLA 440
Cdd:TIGR02168  918 EELREKLAQLELRLEGLEVRIDNLQERLSE---EYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLA 990
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 266-454 1.07e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 266 ELEAKMESLKDEINFT---RVLYEAELAQMQTHVSDTSVVLSMDNNRNLDLDGIIAEVRAQyEDIARKSKAEVESWYQIK 342
Cdd:COG4942  31 QLQQEIAELEKELAALkkeEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKE-IAELRAELEAQKEELAEL 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 343 VQQLQMSADQHGDSLKTTKNEISELNRMIQRL-------RAEIENIKKQSQTLQASVADAE-QRGELA--LKDAYSKRAE 412
Cdd:COG4942 110 LRALYRLGRQPPLALLLSPEDFLDAVRRLQYLkylaparREQAEELRADLAELAALRAELEaERAELEalLAELEEERAA 189

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 82654948 413 LETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLEG 454
Cdd:COG4942 190 LEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 266-456 1.51e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 266 ELEAKMESLKDEINFTRVLYEAELAQMQThvsdtsvvlsmdnnrnldLDGIIAEVRAQYEDIARKSKAEVESWYQIKVQQ 345
Cdd:COG1196 236 ELEAELEELEAELEELEAELEELEAELAE------------------LEAELEELRLELEELELELEEAQAEEYELLAEL 297

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 346 LQMSADqhgdsLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQRGELA---LKDAYSKRAELETALQKAKE 422
Cdd:COG1196 298 ARLEQD-----IARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAeeeLEEAEAELAEAEEALLEAEA 372

                       170       180       190
                ....*....|....*....|....*....|....
gi 82654948 423 DLARLLRDYQALMNVKLALDVEIATYRKLLEGEE 456
Cdd:COG1196 373 ELAEAEEELEELAEELLEALRAAAELAAQLEELE 406
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 199-431 1.65e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.36  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    199 TYINAlRKNLDTLSNDKgrlQSELKMMQDSVEDFKTKYEEEINKRTAAENdfvVLKKDVDA-----------------AY 261
Cdd:pfam12128  647 ALKNA-RLDLRRLFDEK---QSEKDKKNKALAERKDSANERLNSLEAQLK---QLDKKHQAwleeqkeqkreartekqAY 719

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    262 MIKVE--LEAKMESLKDEINFTRVLYEAELAQMQTHVSDTSVVLSMDNNRNLDLDGIIAEVRAQYEDIARKsKAEVESWY 339
Cdd:pfam12128  720 WQVVEgaLDAQLALLKAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVR-RQEVLRYF 798

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    340 QIkvqqLQMSADQHGDSLKTTKNEIS--------ELNRMIQRLRAEIENIKKQSQTLQA---------SVADAEQRGELA 402
Cdd:pfam12128  799 DW----YQETWLQRRPRLATQLSNIEraiselqqQLARLIADTKLRRAKLEMERKASEKqqvrlsenlRGLRCEMSKLAT 874

                          250       260       270
                   ....*....|....*....|....*....|
gi 82654948    403 LK-DAYSKRAELETALQKAKEDLARLLRDY 431
Cdd:pfam12128  875 LKeDANSEQAQGSIGERLAQLEDLKLKRDY 904
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 346-437 1.69e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 1.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 346 LQMSADQHGDSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQR------------GELA-----LKDAYS 408
Cdd:COG4942  11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRiaalarriraleQELAaleaeLAELEK 90

                        90       100
                ....*....|....*....|....*....
gi 82654948 409 KRAELETALQKAKEDLARLLRDYQALMNV 437
Cdd:COG4942  91 EIAELRAELEAQKEELAELLRALYRLGRQ 119
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 264-456 1.74e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 41.26  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   264 KVELEAKMESLKDEINFTRVLYEAELAQMQTHVSDTSVVLSMDNNRNLDLDGIIAEVRAQYEDIARKSKAEVE-----SW 338
Cdd:pfam05557   4 LIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAElnrlkKK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   339 YQIKVQQLQMSADQH----GDSLKTTKNEISELNRMIQR-------LRAEIENIKKQSQTLQASVADAEQRGE------L 401
Cdd:pfam05557  84 YLEALNKKLNEKESQladaREVISCLKNELSELRRQIQRaelelqsTNSELEELQERLDLLKAKASEAEQLRQnlekqqS 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 82654948   402 ALKDAYSKRAELETALQK----------AKEDLARL---------LRDYQALMNV----KLALDVEIATYRKLLEGEE 456
Cdd:pfam05557 164 SLAEAEQRIKELEFEIQSqeqdseivknSKSELARIpelekelerLREHNKHLNEnienKLLLKEEVEDLKRKLEREE 241
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
361-450 2.14e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.91  E-value: 2.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 361 KNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQRGELalkdayskrAELETALQKAKEDLARLLRDYQALMNVKLA 440
Cdd:COG4717 431 EEELEELEEELEELEEELEELREELAELEAELEQLEEDGEL---------AELLQELEELKAELRELAEEWAALKLALEL 501

                        90
                ....*....|
gi 82654948 441 LDVEIATYRK 450
Cdd:COG4717 502 LEEAREEYRE 511
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
267-453 4.19e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.00  E-value: 4.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 267 LEAKMESLKDEINFTRVLYEAELAQMQTHVSDTSVVLS--MDNNRNLDLDG-------IIAEVRAQYEDiARKSKAEVES 337
Cdd:COG3206 162 LEQNLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEeaklllqQLSELESQLAE-ARAELAEAEA 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 338 WYQIKVQQLQMSADQHGD-----SLKTTKNEISELNRMIQRLRA-------EIENIKKQSQTLQASVADAEQRGELALKD 405
Cdd:COG3206 241 RLAALRAQLGSGPDALPEllqspVIQQLRAQLAELEAELAELSArytpnhpDVIALRAQIAALRAQLQQEAQRILASLEA 320

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 82654948 406 AY----SKRAELETALQKAKEDLARLLRDYQALMNVKLALDVEIATYRKLLE 453
Cdd:COG3206 321 ELealqAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQ 372
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 202-443 4.26e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 40.16  E-value: 4.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    202 NALRKNLDTLSNDKGRLQSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAymiKVELEAKmESLKDEINFT 281
Cdd:pfam01576  499 NSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEAL---TQQLEEK-AAAYDKLEKT 574

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    282 RVLYEAELAQMQTHVSDTSVVLSMDNNRNLDLDGIIAE---VRAQYEDiaRKSKAEVESwYQIKVQQLQMSadQHGDSLK 358
Cdd:pfam01576  575 KNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEekaISARYAE--ERDRAEAEA-REKETRALSLA--RALEEAL 649

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948    359 TTKNEISELNRMiqrLRAEIENIKKQSQTLQASVADAEQrgelalkdaySKRAeLETALQKAKEDLARLLRDYQALMNVK 438
Cdd:pfam01576  650 EAKEELERTNKQ---LRAEMEDLVSSKDDVGKNVHELER----------SKRA-LEQQVEEMKTQLEELEDELQATEDAK 715


                   ....*
gi 82654948    439 LALDV 443
Cdd:pfam01576  716 LRLEV 720
PRK11281 PRK11281
mechanosensitive channel MscK;
318-425 5.05e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 39.89  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948   318 AEVRAQYEDIARKSKAEVESwyQIKVQQLQMSADQHgDSLKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVADA-- 395
Cdd:PRK11281   39 ADVQAQLDALNKQKLLEAED--KLVQQDLEQTLALL-DKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEEtr 115

                          90       100       110
                  ....*....|....*....|....*....|
gi 82654948   396 EQRGELALKDAYSKRAELETALQKAKEDLA 425
Cdd:PRK11281  116 ETLSTLSLRQLESRLAQTLDQLQNAQNDLA 145
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
201-434 6.37e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 39.28  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  201 INALRKNLDTLSNDKGRLQSELKMMQDSVEDFKTKYEEEINKRT----AAENDFVVLKKdvdaaymIKVELEAKMESLKD 276
Cdd:PRK03918 551 LEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLkelePFYNEYLELKD-------AEKELEREEKELKK 623

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  277 EinftrvlyEAELAQMQTHVSDTsvvlsmdnnrnldlDGIIAEVRAQYEDIARKskaeveswyqikvqqlqMSADQHgds 356
Cdd:PRK03918 624 L--------EEELDKAFEELAET--------------EKRLEELRKELEELEKK-----------------YSEEEY--- 661

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948  357 lKTTKNEISELNRMIQRLRAEIENIKKQSQTLQASVADAEQRgelaLKDAYSKRAELETaLQKAKEDLARL---LRDYQA 433
Cdd:PRK03918 662 -EELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEE----LEEREKAKKELEK-LEKALERVEELrekVKKYKA 735


                 .
gi 82654948  434 L 434
Cdd:PRK03918 736 L 736
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 198-450 6.73e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.04  E-value: 6.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 198 ETYINALRKNLDTLSNDKGRLQSELKMMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAymiKVELEAKMESLKDE 277
Cdd:COG3883  15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEA---EAEIEERREELGER 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 278 InftRVLYEAELAqmqthVSDTSVVLSMDNnrnldldgiiaevraqYEDIARKskaeveswyqikVQQLQMSADQHGDSL 357
Cdd:COG3883  92 A---RALYRSGGS-----VSYLDVLLGSES----------------FSDFLDR------------LSALSKIADADADLL 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 358 KTtkneiselnrmIQRLRAEIENIKKQSQTLQASVADAEQRGELALKDAYSKRAELETALQKAKEDLARLLRDYQALMNV 437
Cdd:COG3883 136 EE-----------LKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAE 204

                       250
                ....*....|...
gi 82654948 438 KLALDVEIATYRK 450
Cdd:COG3883 205 LAAAEAAAAAAAA 217
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 310-446 7.87e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 7.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82654948 310 NLD-LDGIIAEVRAQYEDIAR-KSKAEveswyqiKVQQLQMSADQHgdSLKTTKNEISELNRMIQRLRAEIENIKKQSQT 387
Cdd:COG1196 187 NLErLEDILGELERQLEPLERqAEKAE-------RYRELKEELKEL--EAELLLLKLRELEAELEELEAELEELEAELEE 257

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82654948 388 LQASVADAEQRGELALKDAYSKRAELETA---LQKAKEDLARLLRDYQALMNVKLALDVEIA 446
Cdd:COG1196 258 LEAELAELEAELEELRLELEELELELEEAqaeEYELLAELARLEQDIARLEERRRELEERLE 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH