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Conserved domains on  [gi|828747244|ref|NP_001296455|]
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small G protein signaling modulator 1 isoform d [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 14-138 2.20e-68

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


:

Pssm-ID: 275431  Cd Length: 176  Bit Score: 222.98  E-value: 2.20e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244  14 TVSLTSPSSVYWDYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPL 93
Cdd:cd15784   54 AKSNSLDSSVYWDYALSVNLDDIVYIHCHQQDDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPL 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 828747244  94 WSQRGKGKVFPKLRKRSPQGSseSTSSDKEDDEATDYVFRIIYPG 138
Cdd:cd15784  134 WSQRGKGKVLPKLRKRSSLTS--SKLSEVKEEQATDYVFRIIYPG 176
TBC super family cl47029
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 594-674 8.21e-15

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


The actual alignment was detected with superfamily member smart00164:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 74.27  E-value: 8.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244   594 LHRIEKDVQRCDRSYWYFTAAN---LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDDQVS-------------- 656
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAfwclvklmerygpn 126

                           90
                   ....*....|....*...
gi 828747244   657 LYSPSCPGTQvVDQAGLE 674
Cdd:smart00164 127 FYLPDMSGLQ-LDLLQLD 143
 
Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 14-138 2.20e-68

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 222.98  E-value: 2.20e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244  14 TVSLTSPSSVYWDYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPL 93
Cdd:cd15784   54 AKSNSLDSSVYWDYALSVNLDDIVYIHCHQQDDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPL 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 828747244  94 WSQRGKGKVFPKLRKRSPQGSseSTSSDKEDDEATDYVFRIIYPG 138
Cdd:cd15784  134 WSQRGKGKVLPKLRKRSSLTS--SKLSEVKEEQATDYVFRIIYPG 176
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 24-104 9.27e-34

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 126.47  E-value: 9.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244   24 YWDYAVTIRLEEIVYLHCHQQ-VDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKV 102
Cdd:pfam12068  68 PWSWAINVNVKELKYIHKHQPnEGSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKL 147


                  ..
gi 828747244  103 FP 104
Cdd:pfam12068 148 FP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 594-674 8.21e-15

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 74.27  E-value: 8.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244   594 LHRIEKDVQRCDRSYWYFTAAN---LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDDQVS-------------- 656
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAfwclvklmerygpn 126

                           90
                   ....*....|....*...
gi 828747244   657 LYSPSCPGTQvVDQAGLE 674
Cdd:smart00164 127 FYLPDMSGLQ-LDLLQLD 143
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 595-652 2.76e-10

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 59.96  E-value: 2.76e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 828747244  595 HRIEKDVQRCDRSYWYFT-AANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 652
Cdd:pfam00566  10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLD 68
COG5210 COG5210
GTPase-activating protein [General function prediction only];
594-650 3.03e-06

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 50.57  E-value: 3.03e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244 594 LHRIEKDVQRCDRSYWYF---TAANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 650
Cdd:COG5210  257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVL 316
 
Name Accession Description Interval E-value
PH_RUTBC cd15784
Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and ...
 14-138 2.20e-68

Rab-binding Pleckstrin homology domain (PH) of small G-protein signaling modulator 1 and similar proteins; Small G-protein signaling modulator 1, or RUN and TBC1 domain containing 2 (RUTBC2), as well as RUTBC1, bind to Rab9A via their Pleckstrin homology (PH) domain. They do not seem to act as GAP proteins that stimulate GTP hydrolysis by Rab9A, and RUTBC2 has been shown to also interact with Rab9B, most likely in a similar manner. RUTBC1 does stimulate GTP hydrolysis by Rab32 and Rab33B, however, while RUTBC2 appears to be a GAP for Rab36. Rab9A and associated proteins control the recycling of mannose-6-phosphate receptors from late endosomes to the trans-Golgi.


Pssm-ID: 275431  Cd Length: 176  Bit Score: 222.98  E-value: 2.20e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244  14 TVSLTSPSSVYWDYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPL 93
Cdd:cd15784   54 AKSNSLDSSVYWDYALSVNLDDIVYIHCHQQDDSGGTVVLVGQDGVQRPPLHFPQGGHLLAFLSCLENGLLPHGQLDPPL 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 828747244  94 WSQRGKGKVFPKLRKRSPQGSseSTSSDKEDDEATDYVFRIIYPG 138
Cdd:cd15784  134 WSQRGKGKVLPKLRKRSSLTS--SKLSEVKEEQATDYVFRIIYPG 176
PH_RBD pfam12068
Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain ...
 24-104 9.27e-34

Rab-binding domain (RBD); This domain has been called the Rab-binding domain (RBD). The domain adopts a Ph-like fold. This domain is found associated with pfam00566.


Pssm-ID: 432305  Cd Length: 149  Bit Score: 126.47  E-value: 9.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244   24 YWDYAVTIRLEEIVYLHCHQQ-VDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKV 102
Cdd:pfam12068  68 PWSWAINVNVKELKYIHKHQPnEGSPSYIILVTQDGGQFPPLHFPHGGHLLLFLSCLESGLFPVVRLDPPLSRSLSKGKL 147


                  ..
gi 828747244  103 FP 104
Cdd:pfam12068 148 FP 149
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 594-674 8.21e-15

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 74.27  E-value: 8.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244   594 LHRIEKDVQRCDRSYWYFTAAN---LEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDDQVS-------------- 656
Cdd:smart00164  47 VHQIEKDLRRTFPEHSFFQDKEgpgQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAfwclvklmerygpn 126

                           90
                   ....*....|....*...
gi 828747244   657 LYSPSCPGTQvVDQAGLE 674
Cdd:smart00164 127 FYLPDMSGLQ-LDLLQLD 143
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 595-652 2.76e-10

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 59.96  E-value: 2.76e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 828747244  595 HRIEKDVQRCDRSYWYFT-AANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDD 652
Cdd:pfam00566  10 EQIEKDVPRTFPHSFFFDnGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLD 68
PH-like cd00900
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 26-79 5.40e-07

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


Pssm-ID: 275390  Cd Length: 89  Bit Score: 48.16  E-value: 5.40e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 828747244  26 DYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCL 79
Cdd:cd00900   36 GLELSIPISDIVNVNVSPQGPSSRYLVLVLKDRGEFVGFSFPKEEDAIEISDAL 89
COG5210 COG5210
GTPase-activating protein [General function prediction only];
594-650 3.03e-06

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 50.57  E-value: 3.03e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747244 594 LHRIEKDVQRCDRSYWYF---TAANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL 650
Cdd:COG5210  257 ISQIEKDLSRTFPDNSLFqteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVL 316
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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