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Conserved domains on  [gi|828747932|ref|NP_001296451|]
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fetuin-B isoform 1 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 172-261 3.15e-15

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 70.44  E-value: 3.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932  172 CPHPVDLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQ---DSCSLQasDSEP 248
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79

                          90
                  ....*....|...
gi 828747932  249 VGLCQGSLIKSPG 261
Cdd:pfam00031  80 LGLCSAQVYKVPW 92
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 49-137 3.70e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 48.19  E-value: 3.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932    49 LRPLGCNDSEVLAVAGFALQNINRVQKDGYMLTLNRVhdARVHRQEDMGSLFYLMLDVLETGCHVLSRKaLKDCGPRIFY 128
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKV--VSAKSQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQG 82


                   ....*....
gi 828747932   129 EtvhGQCKA 137
Cdd:smart00043  83 E---KFCTA 88
MSA-2c super family cl13647
Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this ...
 290-361 3.27e-04

Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species.


The actual alignment was detected with superfamily member pfam12238:

Pssm-ID: 289042  Cd Length: 216  Bit Score: 41.66  E-value: 3.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 828747932  290 PADTQDA--KKLPQKNTAPTSSPSITAPRGSIQHLPEQEEPEDSKGKSPEEPFPVQlDLTTNPQGDTLDVSFLY 361
Cdd:pfam12238 138 PKDVTEEleKELQEKKPSRTSSTETPAPGDAESGVQQPPASTPPQGPAPTTPSPSP-ESSGNLQGQQAGSSFTY 210
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 172-261 3.15e-15

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 70.44  E-value: 3.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932  172 CPHPVDLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQ---DSCSLQasDSEP 248
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79

                          90
                  ....*....|...
gi 828747932  249 VGLCQGSLIKSPG 261
Cdd:pfam00031  80 LGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 168-276 8.49e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 64.37  E-value: 8.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932   168 MCPDCPHPVDLSAPSVLEAATESLAKFNSENPSKQY-ALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQ---DSCSLQA 243
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 828747932   244 sdsEPVGLCQGSLIKSPGvppQRFKKTVTVSCE 276
Cdd:smart00043  81 ---QGEKFCTAKVWEKPW---ENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 171-275 2.46e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 54.40  E-value: 2.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932 171 DCPHPVDLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQDSCSLQASD---SE 247
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKlleEG 80

                         90       100
                 ....*....|....*....|....*...
gi 828747932 248 PVGLCQGSLIKspgVPPQRFKKTVTVSC 275
Cdd:cd00042   81 KKKFCTAKVWE---KPWENFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 49-137 3.70e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 48.19  E-value: 3.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932    49 LRPLGCNDSEVLAVAGFALQNINRVQKDGYMLTLNRVhdARVHRQEDMGSLFYLMLDVLETGCHVLSRKaLKDCGPRIFY 128
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKV--VSAKSQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQG 82


                   ....*....
gi 828747932   129 EtvhGQCKA 137
Cdd:smart00043  83 E---KFCTA 88
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 49-155 2.76e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 39.76  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932  49 LRPLGCNDSEVLAVAGFALQNINRVQKDGYmLTLNRVhdARVHRQEDMGSLFYLMLDVLETGCHVLSRKalKDCGPRIFY 128
Cdd:cd00042    3 PSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKV--LSAKSQVVAGTNYYITVEAGDTNCKKSSVP--LDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 828747932 129 ET-VHGQCKAMFHVNKPRRVLYLPAYNC 155
Cdd:cd00042   78 EEgKKKFCTAKVWEKPWENFKELLSFKC 105
MSA-2c pfam12238
Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this ...
 290-361 3.27e-04

Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species.


Pssm-ID: 289042  Cd Length: 216  Bit Score: 41.66  E-value: 3.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 828747932  290 PADTQDA--KKLPQKNTAPTSSPSITAPRGSIQHLPEQEEPEDSKGKSPEEPFPVQlDLTTNPQGDTLDVSFLY 361
Cdd:pfam12238 138 PKDVTEEleKELQEKKPSRTSSTETPAPGDAESGVQQPPASTPPQGPAPTTPSPSP-ESSGNLQGQQAGSSFTY 210
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 49-145 2.86e-03

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 36.54  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932   49 LRPLGCNDSEVLAVAGFALQNINRvQKDGYMLTLNRVhdARVHRQEDMGSLFYLMLDVLETGChVLSRKALKDCGPRIfy 128
Cdd:pfam00031   3 LSPIPDNSPELQEALDFALAEYNA-KTDNYYFELVEV--KRAKSQVVAGTNYFIKVEVGETDC-SKSKKLLEDCPLLD-- 76

                          90
                  ....*....|....*..
gi 828747932  129 ETVHGQCKamFHVNKPR 145
Cdd:pfam00031  77 EKWLGLCS--AQVYKVP 91
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 172-261 3.15e-15

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 70.44  E-value: 3.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932  172 CPHPVDLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQ---DSCSLQasDSEP 248
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79

                          90
                  ....*....|...
gi 828747932  249 VGLCQGSLIKSPG 261
Cdd:pfam00031  80 LGLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 168-276 8.49e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 64.37  E-value: 8.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932   168 MCPDCPHPVDLSAPSVLEAATESLAKFNSENPSKQY-ALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQ---DSCSLQA 243
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlENCPFLD 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 828747932   244 sdsEPVGLCQGSLIKSPGvppQRFKKTVTVSCE 276
Cdd:smart00043  81 ---QGEKFCTAKVWEKPW---ENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 171-275 2.46e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 54.40  E-value: 2.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932 171 DCPHPVDLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQDSCSLQASD---SE 247
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCKlleEG 80

                         90       100
                 ....*....|....*....|....*...
gi 828747932 248 PVGLCQGSLIKspgVPPQRFKKTVTVSC 275
Cdd:cd00042   81 KKKFCTAKVWE---KPWENFKELLSFKC 105
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 49-137 3.70e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 48.19  E-value: 3.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932    49 LRPLGCNDSEVLAVAGFALQNINRVQKDGYMLTLNRVhdARVHRQEDMGSLFYLMLDVLETGCHVLSRKaLKDCGPRIFY 128
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKV--VSAKSQVVAGTNYYLKVEVGETNCKKLSVD-LENCPFLDQG 82


                   ....*....
gi 828747932   129 EtvhGQCKA 137
Cdd:smart00043  83 E---KFCTA 88
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 49-155 2.76e-04

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 39.76  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932  49 LRPLGCNDSEVLAVAGFALQNINRVQKDGYmLTLNRVhdARVHRQEDMGSLFYLMLDVLETGCHVLSRKalKDCGPRIFY 128
Cdd:cd00042    3 PSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKV--LSAKSQVVAGTNYYITVEAGDTNCKKSSVP--LDCPDCKLL 77

                         90       100
                 ....*....|....*....|....*...
gi 828747932 129 ET-VHGQCKAMFHVNKPRRVLYLPAYNC 155
Cdd:cd00042   78 EEgKKKFCTAKVWEKPWENFKELLSFKC 105
MSA-2c pfam12238
Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this ...
 290-361 3.27e-04

Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species.


Pssm-ID: 289042  Cd Length: 216  Bit Score: 41.66  E-value: 3.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 828747932  290 PADTQDA--KKLPQKNTAPTSSPSITAPRGSIQHLPEQEEPEDSKGKSPEEPFPVQlDLTTNPQGDTLDVSFLY 361
Cdd:pfam12238 138 PKDVTEEleKELQEKKPSRTSSTETPAPGDAESGVQQPPASTPPQGPAPTTPSPSP-ESSGNLQGQQAGSSFTY 210
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 49-145 2.86e-03

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 36.54  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 828747932   49 LRPLGCNDSEVLAVAGFALQNINRvQKDGYMLTLNRVhdARVHRQEDMGSLFYLMLDVLETGChVLSRKALKDCGPRIfy 128
Cdd:pfam00031   3 LSPIPDNSPELQEALDFALAEYNA-KTDNYYFELVEV--KRAKSQVVAGTNYFIKVEVGETDC-SKSKKLLEDCPLLD-- 76

                          90
                  ....*....|....*..
gi 828747932  129 ETVHGQCKamFHVNKPR 145
Cdd:pfam00031  77 EKWLGLCS--AQVYKVP 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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