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Conserved domains on  [gi|85057079|gb|AAI11809|]
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Gfra4 protein, partial [Mus musculus]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10492245)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-4

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-225 1.30e-20

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 84.12  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079   131 CLEPLERCERSRLCRPRLLAFQASCAPAPGSRDRCPeeGGPRCLRVYagligtVVTPNYLDNVSARVAPWCGCAASGNRR 210
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 85057079   211 EECEAFRKLFTRNPC 225
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 34-119 1.05e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 37.51  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079    34 CVDAAEACTADERCQQLRSEYVARCLGRAAPGGRPGPGG-CvrsrcRRALRRFFARGPPALTHALLFCGCEGS-----AC 107
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPArC-----LRAYRMTPNYVDNLGTSLLLWCTCKGSgnqdeEC 75

                          90
                  ....*....|..
gi 85057079   108 AERRRQTFAPAC 119
Cdd:pfam02351  76 EEFRRNFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-225 1.30e-20

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 84.12  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079   131 CLEPLERCERSRLCRPRLLAFQASCAPAPGSRDRCPeeGGPRCLRVYagligtVVTPNYLDNVSARVAPWCGCAASGNRR 210
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 85057079   211 EECEAFRKLFTRNPC 225
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-225 1.16e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 73.44  E-value: 1.16e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079    131 CLEPLERCERSRLCRPRLLAFQASCAPAPGSrdRCPEEGGPRCLRVYaglIGTVVTPNYLDNVSarVAPWCGCAasGNRR 210
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSS--SCPGENSEACLRAY---CGLALRPFYDDNSS--VLLFCTCA--GNRD 71

                           90
                   ....*....|....*
gi 85057079    211 EECEAFRKLFTRNPC 225
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 34-119 1.05e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 37.51  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079    34 CVDAAEACTADERCQQLRSEYVARCLGRAAPGGRPGPGG-CvrsrcRRALRRFFARGPPALTHALLFCGCEGS-----AC 107
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPArC-----LRAYRMTPNYVDNLGTSLLLWCTCKGSgnqdeEC 75

                          90
                  ....*....|..
gi 85057079   108 AERRRQTFAPAC 119
Cdd:pfam02351  76 EEFRRNFTVNSC 87
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-225 1.30e-20

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 84.12  E-value: 1.30e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079   131 CLEPLERCERSRLCRPRLLAFQASCAPAPGSRDRCPeeGGPRCLRVYagligtVVTPNYLDNVSARVAPWCGCAASGNRR 210
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCP--NPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 85057079   211 EECEAFRKLFTRNPC 225
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 131-225 1.16e-16

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 73.44  E-value: 1.16e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079    131 CLEPLERCERSRLCRPRLLAFQASCAPAPGSrdRCPEEGGPRCLRVYaglIGTVVTPNYLDNVSarVAPWCGCAasGNRR 210
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSS--SCPGENSEACLRAY---CGLALRPFYDDNSS--VLLFCTCA--GNRD 71

                           90
                   ....*....|....*
gi 85057079    211 EECEAFRKLFTRNPC 225
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 34-119 1.05e-03

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 37.51  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85057079    34 CVDAAEACTADERCQQLRSEYVARCLGRAAPGGRPGPGG-CvrsrcRRALRRFFARGPPALTHALLFCGCEGS-----AC 107
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGCPNPArC-----LRAYRMTPNYVDNLGTSLLLWCTCKGSgnqdeEC 75

                          90
                  ....*....|..
gi 85057079   108 AERRRQTFAPAC 119
Cdd:pfam02351  76 EEFRRNFTVNSC 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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