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Conserved domains on  [gi|892601623|emb|CNJ59596|]
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membrane protein [Mycobacterium tuberculosis]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11457220)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
61-283 7.25e-30

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


:

Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 114.56  E-value: 7.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  61 SFISAARGGIKTNWVIsMPPG--QSGQLRPV-IALHGKDGNAGMMLDLG-VEQGLARLVKEGK-PAFAVVGVDGgNTYWH 135
Cdd:COG2382   85 TYPSKALGRTRRVWVY-LPPGydNPGKKYPVlYLLDGGGGDEQDWFDQGrLPTILDNLIAAGKiPPMIVVMPDG-GDGGD 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 136 RRSSGGDSGA---MVLDELLPMLTS---MGMDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPALFTsftgstpg 209
Cdd:COG2382  163 RGTEGPGNDAferFLAEELIPFVEKnyrVSADPEHRAIAGLSMGGLAALYAALR-HPDLFGYVGSFSGSFWW-------- 233

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 892601623 210 AFDSYDDYVQHSVLGLPALNS-IPLRVDCGTSDRFYFATRQFVNQLHQPPA---GSFSPGGHDASYWREQLPGELAWM 283
Cdd:COG2382  234 PPGDADRGGWAELLAAGAPKKpLRFYLDVGTEDDLLEANRALAAALKAKGYdveYREFPGGHDWAVWRAALPDFLPWL 311
 
Name Accession Description Interval E-value
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
61-283 7.25e-30

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 114.56  E-value: 7.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  61 SFISAARGGIKTNWVIsMPPG--QSGQLRPV-IALHGKDGNAGMMLDLG-VEQGLARLVKEGK-PAFAVVGVDGgNTYWH 135
Cdd:COG2382   85 TYPSKALGRTRRVWVY-LPPGydNPGKKYPVlYLLDGGGGDEQDWFDQGrLPTILDNLIAAGKiPPMIVVMPDG-GDGGD 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 136 RRSSGGDSGA---MVLDELLPMLTS---MGMDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPALFTsftgstpg 209
Cdd:COG2382  163 RGTEGPGNDAferFLAEELIPFVEKnyrVSADPEHRAIAGLSMGGLAALYAALR-HPDLFGYVGSFSGSFWW-------- 233

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 892601623 210 AFDSYDDYVQHSVLGLPALNS-IPLRVDCGTSDRFYFATRQFVNQLHQPPA---GSFSPGGHDASYWREQLPGELAWM 283
Cdd:COG2382  234 PPGDADRGGWAELLAAGAPKKpLRFYLDVGTEDDLLEANRALAAALKAKGYdveYREFPGGHDWAVWRAALPDFLPWL 311
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 83-283 1.61e-07

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 51.31  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623   83 SGQLRPVIALHGKDGNAGMMldlGVEQGLARLVKEGK--PAFAVV----GVDGGNTYWHRRSSGGDSGAM------VLDE 150
Cdd:pfam00756  20 PGRKYPVLYLLDGTGWFQNG---PAKEGLDRLAASGEipPVIIVGsprgGEVSFYSDWDRGLNATEGPGAyayetfLTQE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  151 LLPML-TSMGMDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPALFTS--FTG-STPGAFDSYDDYVQhsVLGLP 226
Cdd:pfam00756  97 LPPLLdANFPTAPDGRALAGQSMGGLGALYLALK-YPDLFGSVSSFSPILNPSnsMWGpEDDPAWQEGDPVLL--AVALS 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 892601623  227 ALNS-IPLRVDCGTSDRFYFAT------------RQFVNQLHQPPAGSFS---PGGHDASYWREQLPGELAWM 283
Cdd:pfam00756 174 ANNTrLRIYLDVGTREDFLGDQlpveileelapnRELAEQLAYRGVGGYDheyYGGHDWAYWRAQLIAALIDL 246
PLN02442 PLN02442
S-formylglutathione hydrolase
 147-244 9.31e-06

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 46.31  E-value: 9.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 147 VLDELLPMLTSMG--MDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPAL-----------FTSFTGSTPGAFDS 213
Cdd:PLN02442 125 VVKELPKLLSDNFdqLDTSRASIFGHSMGGHGALTIYLK-NPDKYKSVSAFAPIAnpincpwgqkaFTNYLGSDKADWEE 203

                         90       100       110
                 ....*....|....*....|....*....|..
gi 892601623 214 YD-DYVQHSVLGLPAlnsiPLRVDCGTSDRFY 244
Cdd:PLN02442 204 YDaTELVSKFNDVSA----TILIDQGEADKFL 231
 
Name Accession Description Interval E-value
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
61-283 7.25e-30

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 114.56  E-value: 7.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  61 SFISAARGGIKTNWVIsMPPG--QSGQLRPV-IALHGKDGNAGMMLDLG-VEQGLARLVKEGK-PAFAVVGVDGgNTYWH 135
Cdd:COG2382   85 TYPSKALGRTRRVWVY-LPPGydNPGKKYPVlYLLDGGGGDEQDWFDQGrLPTILDNLIAAGKiPPMIVVMPDG-GDGGD 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 136 RRSSGGDSGA---MVLDELLPMLTS---MGMDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPALFTsftgstpg 209
Cdd:COG2382  163 RGTEGPGNDAferFLAEELIPFVEKnyrVSADPEHRAIAGLSMGGLAALYAALR-HPDLFGYVGSFSGSFWW-------- 233

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 892601623 210 AFDSYDDYVQHSVLGLPALNS-IPLRVDCGTSDRFYFATRQFVNQLHQPPA---GSFSPGGHDASYWREQLPGELAWM 283
Cdd:COG2382  234 PPGDADRGGWAELLAAGAPKKpLRFYLDVGTEDDLLEANRALAAALKAKGYdveYREFPGGHDWAVWRAALPDFLPWL 311
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
64-284 6.23e-29

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 110.31  E-value: 6.23e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  64 SAARGGIKTNWVIsMPPGQSGQLRPVI-ALHGKDGN-AGMMLDLGVEQGLARLvkegkpAFAVVGVDGG-NTYWH----R 136
Cdd:COG0627   11 SPALGREMPVSVY-LPPGYDGRPLPVLyLLHGLTGThENWTRKTGAQRLAAEL------GVIVVMPDGGqASFYVdwtqG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 137 RSSGGDSGAMVLDELLPMLTSM---GMDTSRVGFLGWSMGGYGALLLGARLgPARTAGICAISPALFTSFTGSTPGAFDS 213
Cdd:COG0627   84 PAGHYRWETYLTEELPPLIEANfpvSADRERRAIAGLSMGGHGALTLALRH-PDLFRAVAAFSGILDPSQPPWGEKAFDA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 214 Y------DDYVQHSVLGLPAL--NSIPLRVDCGTSDRFYFA-TRQFVNQLH---QPPAGSFSPGGHDASYWREQLPGELA 281
Cdd:COG0627  163 YfgppdrAAWAANDPLALAEKlrAGLPLYIDCGTADPFFLEaNRQLHAALRaagIPHTYRERPGGHSWYYWASFLEDHLP 242


                 ...
gi 892601623 282 WMA 284
Cdd:COG0627  243 FLA 245
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 83-283 1.61e-07

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 51.31  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623   83 SGQLRPVIALHGKDGNAGMMldlGVEQGLARLVKEGK--PAFAVV----GVDGGNTYWHRRSSGGDSGAM------VLDE 150
Cdd:pfam00756  20 PGRKYPVLYLLDGTGWFQNG---PAKEGLDRLAASGEipPVIIVGsprgGEVSFYSDWDRGLNATEGPGAyayetfLTQE 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  151 LLPML-TSMGMDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPALFTS--FTG-STPGAFDSYDDYVQhsVLGLP 226
Cdd:pfam00756  97 LPPLLdANFPTAPDGRALAGQSMGGLGALYLALK-YPDLFGSVSSFSPILNPSnsMWGpEDDPAWQEGDPVLL--AVALS 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 892601623  227 ALNS-IPLRVDCGTSDRFYFAT------------RQFVNQLHQPPAGSFS---PGGHDASYWREQLPGELAWM 283
Cdd:pfam00756 174 ANNTrLRIYLDVGTREDFLGDQlpveileelapnRELAEQLAYRGVGGYDheyYGGHDWAYWRAQLIAALIDL 246
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
88-216 1.26e-06

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 48.95  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  88 PVIAL-HGKDGNAGMMLDLGveqglARLVKEGkpaFAVVGVD--GGNTYWHRRSSGGDSGAM--------------VLDE 150
Cdd:COG4188   63 PLVVLsHGLGGSREGYAYLA-----EHLASHG---YVVAAPDhpGSNAADLSAALDGLADALdpeelwerpldlsfVLDQ 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 892601623 151 LL------PMLTSMgMDTSRVGFLGWSMGGYGALLL-GARLGPARTAGICAISPALFTSFTGSTPGAFDSYDD 216
Cdd:COG4188  135 LLalnksdPPLAGR-LDLDRIGVIGHSLGGYTALALaGARLDFAALRQYCGKNPDLQCRALDLPRLAYDLRDP 206
PLN02442 PLN02442
S-formylglutathione hydrolase
 147-244 9.31e-06

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 46.31  E-value: 9.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 147 VLDELLPMLTSMG--MDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPAL-----------FTSFTGSTPGAFDS 213
Cdd:PLN02442 125 VVKELPKLLSDNFdqLDTSRASIFGHSMGGHGALTIYLK-NPDKYKSVSAFAPIAnpincpwgqkaFTNYLGSDKADWEE 203

                         90       100       110
                 ....*....|....*....|....*....|..
gi 892601623 214 YD-DYVQHSVLGLPAlnsiPLRVDCGTSDRFY 244
Cdd:PLN02442 204 YDaTELVSKFNDVSA----TILIDQGEADKFL 231
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
78-197 1.10e-04

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 42.70  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  78 MPPGQSGQLRPVIALHGKDGNAGMMLDLGVEQglarLVKEGkpaFAVVGVDggntYWHRRSSGGDSGAMVLDELLP---- 153
Cdd:COG1506   15 YLPADGKKYPVVVYVHGGPGSRDDSFLPLAQA----LASRG---YAVLAPD----YRGYGESAGDWGGDEVDDVLAaidy 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 892601623 154 MLTSMGMDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISP 197
Cdd:COG1506   84 LAARPYVDPDRIGIYGHSYGGYMALLAAAR-HPDRFKAAVALAG 126
YpfH COG0400
Predicted esterase [General function prediction only];
89-199 1.18e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 42.20  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  89 VIALHGKDGNagmmldlgvEQGLARLVKE-GKPAFAVVGVDG-------GNTYWHRRSSGGDSGAMVLDELLPMLTSM-- 158
Cdd:COG0400    8 VVLLHGYGGD---------EEDLLPLAPElALPGAAVLAPRApvpegpgGRAWFDLSFLEGREDEEGLAAAAEALAAFid 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 892601623 159 ------GMDTSRVGFLGWSMGGYGALLLGARlGPARTAGICAISPAL 199
Cdd:COG0400   79 elearyGIDPERIVLAGFSQGAAMALSLALR-RPELLAGVVALSGYL 124
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
80-193 1.56e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 41.88  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  80 PGQSGQLRPVIALHGKDGNAGMMLDLGveqglARLVKEGkpaFAVVGVDggnTYWHRRSSGGDSGAMVLDELLPMLTSM- 158
Cdd:COG0412   23 PAGGGPRPGVVVLHEIFGLNPHIRDVA-----RRLAAAG---YVVLAPD---LYGRGGPGDDPDEARALMGALDPELLAa 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 892601623 159 -------------GMDTSRVGFLGWSMGGYGALLLgARLGPARTAGIC 193
Cdd:COG0412   92 dlraaldwlkaqpEVDAGRVGVVGFCFGGGLALLA-AARGPDLAAAVS 138
COG4099 COG4099
Predicted peptidase [General function prediction only];
65-198 3.75e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 41.11  E-value: 3.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  65 AARGGIKTNWVISMPPG-QSGQLRP-VIALHGkDGNAGMMLDLGVEQGLARLVKEGK----PAFAVVGVDGGNTYWhrrs 138
Cdd:COG4099   26 DPSDGDTLPYRLYLPKGyDPGKKYPlVLFLHG-AGERGTDNEKQLTHGAPKFINPENqakfPAIVLAPQCPEDDYW---- 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623 139 SGGDSGAMVLDELLPMLTSMGMDTSRVGFLGWSMGGYGALLLGARLgPARTAGICAISPA 198
Cdd:COG4099  101 SDTKALDAVLALLDDLIAEYRIDPDRIYLTGLSMGGYGTWDLAARY-PDLFAAAVPICGG 159
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 68-199 1.91e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 38.83  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 892601623  68 GGIKTNWVISMPPGqsgqlRPVIALHGKDGNAGMMLDLgveqgLARLvkegKPAFAVVGVD--G-GNTYWHRRSSGGDSG 144
Cdd:COG0596   10 DGVRLHYREAGPDG-----PPVVLLHGLPGSSYEWRPL-----IPAL----AAGYRVIAPDlrGhGRSDKPAGGYTLDDL 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 892601623 145 AMVLDELLPMLtsmgmDTSRVGFLGWSMGGYGALLLgARLGPARTAGICAISPAL 199
Cdd:COG0596   76 ADDLAALLDAL-----GLERVVLVGHSMGGMVALEL-AARHPERVAGLVLVDEVL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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