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Conserved domains on  [gi|8928355|sp|Q9VAN0|]
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RecName: Full=Probable phosphoserine aminotransferase; Short=PSAT; AltName: Full=Phosphohydroxythreonine aminotransferase

Protein Classification

3-phosphoserine/phosphohydroxythreonine aminotransferase( domain architecture ID 10089690)

3-phosphoserine/phosphohydroxythreonine aminotransferase catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
 3-360 0e+00

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


:

Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 637.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    3 INFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAVA 82
Cdd:cd00611   1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAAVP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   83 LNLIGKTGTADYVITGSWSAKAAKEAAQYGT-VNAVLPKLA-KYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPE 160
Cdd:cd00611  81 LNLLGDKGTADYVVTGAWSAKAAKEAKRYGGvVVIVAAKEEgKYTKIPDVETWDLAPDAAYVHYCSNETIHGVEFDEVPD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  161 VPaGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTF 240
Cdd:cd00611 161 TG-GVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPTF 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  241 GIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNGFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAEA 320
Cdd:cd00611 240 AIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRARSRMNVPFRL----GKEELEKEFLKEAEA 315

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 8928355  321 EGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYK 360
Cdd:cd00611 316 AGMIGLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
 
Name Accession Description Interval E-value
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
 3-360 0e+00

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 637.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    3 INFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAVA 82
Cdd:cd00611   1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAAVP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   83 LNLIGKTGTADYVITGSWSAKAAKEAAQYGT-VNAVLPKLA-KYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPE 160
Cdd:cd00611  81 LNLLGDKGTADYVVTGAWSAKAAKEAKRYGGvVVIVAAKEEgKYTKIPDVETWDLAPDAAYVHYCSNETIHGVEFDEVPD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  161 VPaGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTF 240
Cdd:cd00611 161 TG-GVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPTF 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  241 GIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNGFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAEA 320
Cdd:cd00611 240 AIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRARSRMNVPFRL----GKEELEKEFLKEAEA 315

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 8928355  321 EGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYK 360
Cdd:cd00611 316 AGMIGLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
PRK05355 PRK05355
3-phosphoserine/phosphohydroxythreonine transaminase;
1-363 0e+00

3-phosphoserine/phosphohydroxythreonine transaminase;


Pssm-ID: 235428  Cd Length: 360  Bit Score: 588.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     1 MVINFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAA 80
Cdd:PRK05355   3 RVYNFSAGPAMLPEEVLEQAQQELLDWNGSGMSVMEISHRSKEFEAVAEEAEADLRELLNIPDNYKVLFLQGGASLQFAM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    81 VALNLIGKTGTADYVITGSWSAKAAKEAAQYGTVNAVLP-KLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVP 159
Cdd:PRK05355  83 VPMNLLGGGKKADYVDTGSWSKKAIKEAKKYGEVNVAASsEDDGFTYIPPLDEWQLSDDAAYVHYTSNETIDGTEFHELP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   160 EVpAGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPT 239
Cdd:PRK05355 163 DT-GDVPLVADMSSDILSRPIDVSKFGLIYAGAQKNIGPAGLTIVIVREDLLGRALPSIPSMLDYKTHADNDSMYNTPPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   240 FGIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNgFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAE 319
Cdd:PRK05355 242 FAIYLAGLVFKWLKEQGGVAAMEKRNQEKAALLYDAIDSSD-FYRNPVAPEDRSRMNVPFTL----ADEELDKKFLAEAK 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 8928355   320 AEGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYKNNK 363
Cdd:PRK05355 317 AAGLVGLKGHRSVGGMRASIYNAMPLEGVQALVDFMKEFERRHG 360
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
 2-362 0e+00

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 562.39  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    2 VINFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAV 81
Cdd:COG1932   3 VYNFSAGPAKLPEEVLEQAQAELLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGIPDGYEVLFLQGGATAQFAMV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   82 ALNLIGKTGTADYVITGSWSAKAAKEAAQYGTVNAVL-PKLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPE 160
Cdd:COG1932  83 PMNLLRGGKKADYLVTGEWSKKAIKEAKKYGEVNVVAsSEDDNFGYIPKPEEWQLSPDADYVHYTSNETITGVEFHELPD 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  161 VpAGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTF 240
Cdd:COG1932 163 V-GDVPLVADMSSDILSRPVDVSKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSMYNTPPTF 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  241 GIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNgFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAEA 320
Cdd:COG1932 242 AIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDASD-FYTNPVDPEDRSRMNVTFDL----ADEELDAAFLAEAKA 316

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 8928355  321 EGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYKNN 362
Cdd:COG1932 317 AGLVGLKGHRSVGGMRASIYNAMPLEGVEALVDFMDEFERRH 358
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
 10-362 0e+00

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 548.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     10 AKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAVALNLIGKT 89
Cdd:TIGR01364   1 AALPEEVLEQAQKELLNFNGTGMSVMEISHRSKEFEAVANEAESDLRELLNIPDNYEVLFLQGGATGQFAAVPLNLLAEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     90 GTADYVITGSWSAKAAKEAAQYGTVNAVL-PKLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPEVpAGVPLV 168
Cdd:TIGR01364  81 KVADYIVTGAWSKKAAKEAKKYGVVNVVAsGKEGNYTKIPDPSTWEISEDAAYVHYCANETIHGVEFRELPDV-KNAPLV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    169 ADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTFGIYVMGLV 248
Cdd:TIGR01364 160 ADMSSNILSRPIDVSKFGLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGLV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    249 FKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNGFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAEAEGMIQLKG 328
Cdd:TIGR01364 240 FKWLKEQGGVKAIEKRNQAKAQLLYDTIDNSNGFYRNPVDPRNRSRMNVVFTL----GNEELEKRFLKEAEERGLVSLKG 315

                         330       340       350
                  ....*....|....*....|....*....|....
gi 8928355    329 HRSVGGIRASLYNAVTLAETQQLANLMLAFYKNN 362
Cdd:TIGR01364 316 HRSVGGMRASIYNAMPLEGVQALVDFMKEFQKKH 349
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 2-351 8.39e-60

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 197.08  E-value: 8.39e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355      2 VINFAAGPAKLPEEVLKEVQENLVNCNGSGISvmEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGgTGQFAAV 81
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVHR--GVHTLGKEATQAYEEAREKVAEFINAPSNDEIIFTSGT-TEAINLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     82 ALNL---IGKTGTADYVITGSWSAK-AAKEAAQYGTVNAVLPKLAKYTTVPRQE-TWKLDPNASYVYYCDNETVEGVEFD 156
Cdd:pfam00266  78 ALSLgrsLKPGDEIVITEMEHHANLvPWQELAKRTGARVRVLPLDEDGLLDLDElEKLITPKTKLVAITHVSNVTGTIQP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    157 fVPEV-----PAGVPLVADMSSNFLSRPFDVSKFGV--IYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDK 229
Cdd:pfam00266 158 -VPEIgklahQYGALVLVDAAQAIGHRPIDVQKLGVdfLAFSGHKLYGPTGIGVLYGRRDLLEKMPPLLGGGGMIETVSL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    230 NNSLLN---------TPPTFGIYVMGLVFKWIKrNGGVAGMAKLAAAKSKLIYDTInQSNGFYYCPVDVNVRSRMNVPFR 300
Cdd:pfam00266 237 QESTFAdapwkfeagTPNIAGIIGLGAALEYLS-EIGLEAIEKHEHELAQYLYERL-LSLPGIRLYGPERRASIISFNFK 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 8928355    301 IGSASgDDALekeFLSKAEAE-------GMIQLKGHRSVGGIRASLYNAVTLAETQQL 351
Cdd:pfam00266 315 GVHPH-DVAT---LLDESGIAvrsghhcAQPLMVRLGLGGTVRASFYIYNTQEDVDRL 368
 
Name Accession Description Interval E-value
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
 3-360 0e+00

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 637.80  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    3 INFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAVA 82
Cdd:cd00611   1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAAVP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   83 LNLIGKTGTADYVITGSWSAKAAKEAAQYGT-VNAVLPKLA-KYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPE 160
Cdd:cd00611  81 LNLLGDKGTADYVVTGAWSAKAAKEAKRYGGvVVIVAAKEEgKYTKIPDVETWDLAPDAAYVHYCSNETIHGVEFDEVPD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  161 VPaGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTF 240
Cdd:cd00611 161 TG-GVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPTF 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  241 GIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNGFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAEA 320
Cdd:cd00611 240 AIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRARSRMNVPFRL----GKEELEKEFLKEAEA 315

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 8928355  321 EGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYK 360
Cdd:cd00611 316 AGMIGLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
PRK05355 PRK05355
3-phosphoserine/phosphohydroxythreonine transaminase;
1-363 0e+00

3-phosphoserine/phosphohydroxythreonine transaminase;


Pssm-ID: 235428  Cd Length: 360  Bit Score: 588.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     1 MVINFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAA 80
Cdd:PRK05355   3 RVYNFSAGPAMLPEEVLEQAQQELLDWNGSGMSVMEISHRSKEFEAVAEEAEADLRELLNIPDNYKVLFLQGGASLQFAM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    81 VALNLIGKTGTADYVITGSWSAKAAKEAAQYGTVNAVLP-KLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVP 159
Cdd:PRK05355  83 VPMNLLGGGKKADYVDTGSWSKKAIKEAKKYGEVNVAASsEDDGFTYIPPLDEWQLSDDAAYVHYTSNETIDGTEFHELP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   160 EVpAGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPT 239
Cdd:PRK05355 163 DT-GDVPLVADMSSDILSRPIDVSKFGLIYAGAQKNIGPAGLTIVIVREDLLGRALPSIPSMLDYKTHADNDSMYNTPPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   240 FGIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNgFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAE 319
Cdd:PRK05355 242 FAIYLAGLVFKWLKEQGGVAAMEKRNQEKAALLYDAIDSSD-FYRNPVAPEDRSRMNVPFTL----ADEELDKKFLAEAK 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 8928355   320 AEGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYKNNK 363
Cdd:PRK05355 317 AAGLVGLKGHRSVGGMRASIYNAMPLEGVQALVDFMKEFERRHG 360
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
 2-362 0e+00

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 562.39  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    2 VINFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAV 81
Cdd:COG1932   3 VYNFSAGPAKLPEEVLEQAQAELLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGIPDGYEVLFLQGGATAQFAMV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   82 ALNLIGKTGTADYVITGSWSAKAAKEAAQYGTVNAVL-PKLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPE 160
Cdd:COG1932  83 PMNLLRGGKKADYLVTGEWSKKAIKEAKKYGEVNVVAsSEDDNFGYIPKPEEWQLSPDADYVHYTSNETITGVEFHELPD 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  161 VpAGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTF 240
Cdd:COG1932 163 V-GDVPLVADMSSDILSRPVDVSKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSMYNTPPTF 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  241 GIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNgFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAEA 320
Cdd:COG1932 242 AIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDASD-FYTNPVDPEDRSRMNVTFDL----ADEELDAAFLAEAKA 316

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 8928355  321 EGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYKNN 362
Cdd:COG1932 317 AGLVGLKGHRSVGGMRASIYNAMPLEGVEALVDFMDEFERRH 358
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
 10-362 0e+00

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 548.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     10 AKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAVALNLIGKT 89
Cdd:TIGR01364   1 AALPEEVLEQAQKELLNFNGTGMSVMEISHRSKEFEAVANEAESDLRELLNIPDNYEVLFLQGGATGQFAAVPLNLLAEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     90 GTADYVITGSWSAKAAKEAAQYGTVNAVL-PKLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPEVpAGVPLV 168
Cdd:TIGR01364  81 KVADYIVTGAWSKKAAKEAKKYGVVNVVAsGKEGNYTKIPDPSTWEISEDAAYVHYCANETIHGVEFRELPDV-KNAPLV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    169 ADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTFGIYVMGLV 248
Cdd:TIGR01364 160 ADMSSNILSRPIDVSKFGLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGLV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    249 FKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNGFYYCPVDVNVRSRMNVPFRIgsasGDDALEKEFLSKAEAEGMIQLKG 328
Cdd:TIGR01364 240 FKWLKEQGGVKAIEKRNQAKAQLLYDTIDNSNGFYRNPVDPRNRSRMNVVFTL----GNEELEKRFLKEAEERGLVSLKG 315

                         330       340       350
                  ....*....|....*....|....*....|....
gi 8928355    329 HRSVGGIRASLYNAVTLAETQQLANLMLAFYKNN 362
Cdd:TIGR01364 316 HRSVGGMRASIYNAMPLEGVQALVDFMKEFQKKH 349
PLN02452 PLN02452
phosphoserine transaminase
 2-362 1.61e-179

phosphoserine transaminase


Pssm-ID: 178071  Cd Length: 365  Bit Score: 502.30  E-value: 1.61e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     2 VINFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAV 81
Cdd:PLN02452   8 VFNFSAGPATLPANVLAKAQAELYNWEGSGMSVMEMSHRGKEFLSIIQKAEADLRELLDIPDNYEVLFLQGGASTQFAAI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    82 ALNLIGKTGTADYVITGSWSAKAAKEAAQYGTVN-AVLPKLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPE 160
Cdd:PLN02452  88 PLNLCKPGDKADFVVTGSWSKKAAKEAKKYCKTNvIASGKDEKYTKIPSVSEWELTPDAKFVHICANETIHGVEFKDYPD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   161 VPaGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTF 240
Cdd:PLN02452 168 VG-NVPLVADMSSNFLSKPVDVSKYGVIYAGAQKNVGPSGVTIVIIRKDLIGNARPITPGMLDYKIHAENDSLYNTPPCF 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   241 GIYVMGLVFKWIKRNGGVAGMAKLAAAKSKLIYDTINQSNGFYYCPVDVNVRSRMNVPFRIGSASgddaLEKEFLSKAEA 320
Cdd:PLN02452 247 GIYMCGLVFEDLLAQGGLKAMEKRNIRKADLLYDAIDESNGFYVCPVEKSVRSLMNVPFTLGGSE----LEAEFVKEAAK 322

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 8928355   321 EGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYKNN 362
Cdd:PLN02452 323 AGMVQLKGHRSVGGMRASIYNAMPLAGVEKLVAFMKDFQAKH 364
PRK12462 PRK12462
phosphoserine aminotransferase; Provisional
 3-361 2.29e-120

phosphoserine aminotransferase; Provisional


Pssm-ID: 183540  Cd Length: 364  Bit Score: 352.19  E-value: 2.29e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     3 INFAAGPAKLPEEVLKEVQENLVNCNGSGISVMEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGGTGQFAAVA 82
Cdd:PRK12462   6 LNFSGGPGALPDTVLEQVRQAVVELPETGLSVLGMSHRSSWFSSLLAQAEADLRDLLGIPDEYGVVFLQGGSSLQFSMIP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    83 LNLI-GKTGTADYVITGSWSAKAAKEAAQYGTVNAVLP-KLAKYTTVPRQETWKLDPNASYVYYCDNETVEGVEFDFVPE 160
Cdd:PRK12462  86 MNFSrPGAAAPEYVTTGYWSRKAIGEASRVAAMRVVWDgAASGYRTLPSLAELDWDARAPFRHYVSNETVEGLQFPDAAG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   161 VPaGVPLVADMSSNFLSRPFDVSKFGVIYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDKNNSLLNTPPTF 240
Cdd:PRK12462 166 LP-DSPLIADMSSDFMSRPFDVEAYGMVYAHAQKNLGPAGVTVAIIRRALLERVPDTLPPMLDFRTHVEHRSNYNTPPVF 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   241 GIYVMGLVFKWIKRN-GGVAGMAKLAAAKSKLIYDTINQSNGFYYCPVDVNVRSRMNVPFRIGSAsgddALEKEFLSKAE 319
Cdd:PRK12462 245 AIYVMALVLRWIRDEiGGVHAMRDINARKAAMLYATLDALNEVIDCHAHRAARSTMNVAFRFRQP----RLDTLFKEQST 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 8928355   320 AEGMIQLKGHRSVGGIRASLYNAVTLAETQQLANLMLAFYKN 361
Cdd:PRK12462 321 EAGFCGLSGHRSIGGIRASLYNAVSEQAVSRLCAFLKDFAIR 362
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 2-351 8.39e-60

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 197.08  E-value: 8.39e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355      2 VINFAAGPAKLPEEVLKEVQENLVNCNGSGISvmEMSHRSSNYAKIHDATISDLRELLNVPSNYKILLMQGGgTGQFAAV 81
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVHR--GVHTLGKEATQAYEEAREKVAEFINAPSNDEIIFTSGT-TEAINLV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     82 ALNL---IGKTGTADYVITGSWSAK-AAKEAAQYGTVNAVLPKLAKYTTVPRQE-TWKLDPNASYVYYCDNETVEGVEFD 156
Cdd:pfam00266  78 ALSLgrsLKPGDEIVITEMEHHANLvPWQELAKRTGARVRVLPLDEDGLLDLDElEKLITPKTKLVAITHVSNVTGTIQP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    157 fVPEV-----PAGVPLVADMSSNFLSRPFDVSKFGV--IYAGAQKNIGPAGTTVIIVRDDLIGKHLKITPSILNFEQMDK 229
Cdd:pfam00266 158 -VPEIgklahQYGALVLVDAAQAIGHRPIDVQKLGVdfLAFSGHKLYGPTGIGVLYGRRDLLEKMPPLLGGGGMIETVSL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    230 NNSLLN---------TPPTFGIYVMGLVFKWIKrNGGVAGMAKLAAAKSKLIYDTInQSNGFYYCPVDVNVRSRMNVPFR 300
Cdd:pfam00266 237 QESTFAdapwkfeagTPNIAGIIGLGAALEYLS-EIGLEAIEKHEHELAQYLYERL-LSLPGIRLYGPERRASIISFNFK 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 8928355    301 IGSASgDDALekeFLSKAEAE-------GMIQLKGHRSVGGIRASLYNAVTLAETQQL 351
Cdd:pfam00266 315 GVHPH-DVAT---LLDESGIAvrsghhcAQPLMVRLGLGGTVRASFYIYNTQEDVDRL 368
PRK03080 PRK03080
phosphoserine transaminase;
4-324 1.32e-15

phosphoserine transaminase;


Pssm-ID: 235103  Cd Length: 378  Bit Score: 77.15  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355     4 NFAAGP-AKLPEEVLkevqENLVNcngsgiSVMEMSHRSS-NYAKIHDAtISDLRELLNVPSNYKILLMQGGGTGQFAAV 81
Cdd:PRK03080  15 RFSSGPcKKRPGWQL----EALAD------ALLGRSHRQKpVKALLKRV-IEGTRELLSLPEGYEVGIVPGSDTGAWEMA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    82 ALNLIGKTGtADYVITGSWSAKAAKEA-------------AQYGTvnavLPKLAKyttvprqetwkLDPNASYVYyCDNE 148
Cdd:PRK03080  84 LWSLLGARR-VDHLAWESFGSKWATDVvkqlkledprvleADYGS----LPDLSA-----------VDFDRDVVF-TWNG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   149 TVEGVE---FDFVPEVPAGVPLVaDMSSNFLSRPFDVSKFGVIYAGAQKNIG-PAGTTVIIVRDDLIGKHLKITPS---- 220
Cdd:PRK03080 147 TTTGVRvpvARWIGADREGLTIC-DATSAAFALPLDWSKLDVYTFSWQKVLGgEGGHGMAILSPRAVERLESYTPArpip 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   221 -ILNFEQMDK------NNSLLNTPPtfgiyvMGLVF------KWIKRNGGVAGMAKLAAAKSKLIYDTINQSNGFYYCPV 287
Cdd:PRK03080 226 kFFRLTKGGKaiensfKGQTINTPS------MLTVEdyldqlDWANSIGGLDALIARTAANASVLYDWAEKTPWATPLVA 299

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 8928355   288 DVNVRSRMNVPFRIgsASGDDALEKEFLSKAEAEGMI 324
Cdd:PRK03080 300 DPATRSNTSVTLDF--VDAQAAVDAAAVAKLLRENGA 334
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 54-207 1.43e-12

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 65.10  E-value: 1.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   54 DLRELLNvPSNYKILLmQGGGTGQFAAVALNLIGKTGTADYVITGSWSAKAAKEAAQYGTVNAVLPKLAKYTTVPRQ--E 131
Cdd:cd01494   8 KLARLLQ-PGNDKAVF-VPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELAGAKPVPVPVDDAGYGGLDVAilE 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  132 TWKLDPNASYVYYCDNETVEGV-----EFDFVPEvPAGVPLVADMSSNFLSRPF-----DVSKFGVIYAGAQKNIGPAGT 201
Cdd:cd01494  86 ELKAKPNVALIVITPNTTSGGVlvplkEIRKIAK-EYGILLLVDAASAGGASPApgvliPEGGADVVTFSLHKNLGGEGG 164


                ....*.
gi 8928355  202 TVIIVR 207
Cdd:cd01494 165 GVVIVK 170
AGAT_like cd06451
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ...
 5-243 4.66e-10

Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.


Pssm-ID: 99744 [Multi-domain]  Cd Length: 356  Bit Score: 60.38  E-value: 4.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355    5 FAAGPAKLPEEVLKevqenlvncngsgISVMEM-SHRSSNYAKIHDATISDLRELLNvPSNYKILLMQGGGTGQFAAVAL 83
Cdd:cd06451   3 LIPGPSNVPPRVLK-------------AMNRPMlGHRSPEFLALMDEILEGLRYVFQ-TENGLTFLLSGSGTGAMEAALS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355   84 NLIGKTGTADYVITGSWSAKAAKEAAQYGTVNAVLPK-------LAKYTTVPRQEtwklDPNASYVYYcdNETVEGVEFD 156
Cdd:cd06451  69 NLLEPGDKVLVGVNGVFGDRWADMAERYGADVDVVEKpwgeavsPEEIAEALEQH----DIKAVTLTH--NETSTGVLNP 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8928355  157 fVPEVPA-----GVPLVADMSSNFLSRPFDVSKFGV--IYAGAQKNIG-PAGTTVIIVRDDLIGKHLKITP---SILNFE 225
Cdd:cd06451 143 -LEGIGAlakkhDALLIVDAVSSLGGEPFRMDEWGVdvAYTGSQKALGaPPGLGPIAFSERALERIKKKTKpkgFYFDLL 221

                       250       260
                ....*....|....*....|..
gi 8928355  226 QM----DKNNSLLNTPPTFGIY 243
Cdd:cd06451 222 LLlkywGEGYSYPHTPPVNLLY 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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