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Conserved domains on  [gi|893553071|ref|NP_001297577|]
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coiled-coil domain-containing protein 122 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 5-212 3.15e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 3.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071     5 DAAMENSKLQCGRLEAQIESLYSESLKLKFDTETAQEKFEEQMIKYNAYYVKIKAYKDNLGEIKSQCPFM-TELYEKRDL 83
Cdd:TIGR02169  307 ERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVdKEFAETRDE 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071    84 IKNLKTMKEDLMENLQDSQGNCT------IQIQEDISEIKNKIMTVKESITEktsfVEEEKKThekLRKEIEVQHKRyda 157
Cdd:TIGR02169  387 LKDYREKLEKLKREINELKRELDrlqeelQRLSEELADLNAAIAGIEAKINE----LEEEKED---KALEIKKQEWK--- 456

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 893553071   158 iLKRLHCQMNKIQLNRRKWQWNIQQLEKTAAELKKRIREKEASEIQSRPAAPWER 212
Cdd:TIGR02169  457 -LEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGR 510
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 5-212 3.15e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 3.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071     5 DAAMENSKLQCGRLEAQIESLYSESLKLKFDTETAQEKFEEQMIKYNAYYVKIKAYKDNLGEIKSQCPFM-TELYEKRDL 83
Cdd:TIGR02169  307 ERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVdKEFAETRDE 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071    84 IKNLKTMKEDLMENLQDSQGNCT------IQIQEDISEIKNKIMTVKESITEktsfVEEEKKThekLRKEIEVQHKRyda 157
Cdd:TIGR02169  387 LKDYREKLEKLKREINELKRELDrlqeelQRLSEELADLNAAIAGIEAKINE----LEEEKED---KALEIKKQEWK--- 456

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 893553071   158 iLKRLHCQMNKIQLNRRKWQWNIQQLEKTAAELKKRIREKEASEIQSRPAAPWER 212
Cdd:TIGR02169  457 -LEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGR 510
 
Name Accession Description Interval E-value
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 5-212 3.15e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 3.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071     5 DAAMENSKLQCGRLEAQIESLYSESLKLKFDTETAQEKFEEQMIKYNAYYVKIKAYKDNLGEIKSQCPFM-TELYEKRDL 83
Cdd:TIGR02169  307 ERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVdKEFAETRDE 386

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071    84 IKNLKTMKEDLMENLQDSQGNCT------IQIQEDISEIKNKIMTVKESITEktsfVEEEKKThekLRKEIEVQHKRyda 157
Cdd:TIGR02169  387 LKDYREKLEKLKREINELKRELDrlqeelQRLSEELADLNAAIAGIEAKINE----LEEEKED---KALEIKKQEWK--- 456

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 893553071   158 iLKRLHCQMNKIQLNRRKWQWNIQQLEKTAAELKKRIREKEASEIQSRPAAPWER 212
Cdd:TIGR02169  457 -LEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGR 510
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 18-200 1.33e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071    18 LEAQIESLYSESLKLKFDTETAQEKFEEQMIKYNAYYVKIKAYKDNLGEIKSQcpfmteLYEKRDLIKNLKTMKEDLMEN 97
Cdd:TIGR02168  265 LEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQ------LEELEAQLEELESKLDELAEE 338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893553071    98 LQdsqgnctiQIQEDISEIKNKIMTVKESITEKTSFVEEEKKTHEKLRKEIEVQHKRYDAILKRLHCQMNKIQLNRRKwq 177
Cdd:TIGR02168  339 LA--------ELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR-- 408

                          170       180
                   ....*....|....*....|...
gi 893553071   178 wnIQQLEKTAAELKKRIREKEAS 200
Cdd:TIGR02168  409 --LERLEDRRERLQQEIEELLKK 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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