NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|955529504|ref|XP_014647464|]
View 

PREDICTED: UPF0469 protein KIAA0907 homolog isoform X3 [Ceratotherium simum simum]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KH-I_KHDC4_rpt2 cd22386
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ...
 229-330 4.60e-62

first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the second one.


:

Pssm-ID: 411814 [Multi-domain]  Cd Length: 102  Bit Score: 194.31  E-value: 4.60e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 229 HYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAA 308
Cdd:cd22386    1 KYYQEKVFVGLEHAPPGFNVRGKLIGPGGSNVKHIQQETGAKVQLRGKGSGFIEPASGREADEPLHLLISHPDPEGLQQA 80

                         90       100
                 ....*....|....*....|..
gi 955529504 309 KKLCENLLQTVHAEYSRFVNQI 330
Cdd:cd22386   81 KKLCEDLLQTVHQEYGEFQQQP 102
KH-I_KHDC4_rpt1 cd22385
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ...
 99-182 2.75e-48

first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif.


:

Pssm-ID: 411813  Cd Length: 84  Bit Score: 158.14  E-value: 2.75e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504  99 KDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRI 178
Cdd:cd22385    1 GDDLYVAEIEINDLPNTCRNLLTKGSTQEEIQKESGAAVSTRGRYMPPEEKATFNPGERPLYLHVQAPTKEAVDRAVNKI 80


                 ....
gi 955529504 179 KEII 182
Cdd:cd22385   81 NEII 84
 
Name Accession Description Interval E-value
KH-I_KHDC4_rpt2 cd22386
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ...
 229-330 4.60e-62

first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the second one.


Pssm-ID: 411814 [Multi-domain]  Cd Length: 102  Bit Score: 194.31  E-value: 4.60e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 229 HYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAA 308
Cdd:cd22386    1 KYYQEKVFVGLEHAPPGFNVRGKLIGPGGSNVKHIQQETGAKVQLRGKGSGFIEPASGREADEPLHLLISHPDPEGLQQA 80

                         90       100
                 ....*....|....*....|..
gi 955529504 309 KKLCENLLQTVHAEYSRFVNQI 330
Cdd:cd22386   81 KKLCEDLLQTVHQEYGEFQQQP 102
KH-I_KHDC4_rpt1 cd22385
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ...
 99-182 2.75e-48

first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif.


Pssm-ID: 411813  Cd Length: 84  Bit Score: 158.14  E-value: 2.75e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504  99 KDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRI 178
Cdd:cd22385    1 GDDLYVAEIEINDLPNTCRNLLTKGSTQEEIQKESGAAVSTRGRYMPPEEKATFNPGERPLYLHVQAPTKEAVDRAVNKI 80


                 ....
gi 955529504 179 KEII 182
Cdd:cd22385   81 NEII 84
 
Name Accession Description Interval E-value
KH-I_KHDC4_rpt2 cd22386
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ...
 229-330 4.60e-62

first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the second one.


Pssm-ID: 411814 [Multi-domain]  Cd Length: 102  Bit Score: 194.31  E-value: 4.60e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 229 HYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAA 308
Cdd:cd22386    1 KYYQEKVFVGLEHAPPGFNVRGKLIGPGGSNVKHIQQETGAKVQLRGKGSGFIEPASGREADEPLHLLISHPDPEGLQQA 80

                         90       100
                 ....*....|....*....|..
gi 955529504 309 KKLCENLLQTVHAEYSRFVNQI 330
Cdd:cd22386   81 KKLCEDLLQTVHQEYGEFQQQP 102
KH-I_KHDC4_rpt1 cd22385
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ...
 99-182 2.75e-48

first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif.


Pssm-ID: 411813  Cd Length: 84  Bit Score: 158.14  E-value: 2.75e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504  99 KDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRI 178
Cdd:cd22385    1 GDDLYVAEIEINDLPNTCRNLLTKGSTQEEIQKESGAAVSTRGRYMPPEEKATFNPGERPLYLHVQAPTKEAVDRAVNKI 80


                 ....
gi 955529504 179 KEII 182
Cdd:cd22385   81 NEII 84
KH-I_RIK_like_rpt2 cd22472
second type I K homology (KH) RNA-binding domain found in Arabidopsis thaliana protein RIK and ...
 235-326 3.47e-21

second type I K homology (KH) RNA-binding domain found in Arabidopsis thaliana protein RIK and similar proteins; RIK, also called rough sheath 2-interacting KH domain protein, or RS2-interacting KH domain protein, is a RNA binding protein that acts together with RS2/AS1 in the recruitment of HIRA. RIK contains two type I K homology (KH) RNA-binding domains. The model corresponds to the second one.


Pssm-ID: 411900  Cd Length: 96  Bit Score: 87.11  E-value: 3.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 235 LFVGLEhAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGciepaSGREAFEPMYIYISHPKPEGLAAAKKLCEN 314
Cdd:cd22472    7 LYVGIE-APPSFNLAGRIRGPNNSYLQHIASATGATVALRGRGSG-----GAPEGPEPLHLFLSASDPKALEEARGLAEN 80

                         90
                 ....*....|..
gi 955529504 315 LLQTVHAEYSRF 326
Cdd:cd22472   81 LIDTVRADFKAA 92
KH-I_DDX46_like cd22387
type I K homology (KH) RNA-binding domain found in the family of DEAD box protein 46 (DDX46); ...
 99-182 1.17e-15

type I K homology (KH) RNA-binding domain found in the family of DEAD box protein 46 (DDX46); The DDX46 family includes DEAD box protein 46 (DDX46), fungal pre-mRNA-processing ATP-dependent RNA helicase PRP5, Arabidopsis thaliana DEAD-box ATP-dependent RNA helicase RH42 and similar proteins. DDX46, also called PRP5 homolog, is an ATP-dependent RNA helicase that plays an essential role in splicing, either prior to, or during splicing A complex formation. It inhibits antiviral innate responses by entrapping selected antiviral transcripts in the nucleus. It is also involved in the development of several tumors. PRP5 is an ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. It catalyzes an ATP-dependent conformational change of U2 snRNP. PRP5 interacts with the U2 snRNP and HSH155. RH42, also called DEAD-box RNA helicase RCF1, or REGULATOR OF CBF GENE EXPRESSION 1, is a helicase required for pre-mRNA splicing, cold-responsive gene regulation and cold tolerance. Members in this family contain a divergent KH domain that lacks the RNA-binding GXXG motif.


Pssm-ID: 411815  Cd Length: 82  Bit Score: 71.54  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504  99 KDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMttEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRI 178
Cdd:cd22387    1 NNGNFVEEFEINDYPQIARLKVTSKEVLNSIMEETGATITIKGQYY--PPGKKPKPGERKLYLLIEGATEESVQSARNEI 78


                 ....
gi 955529504 179 KEII 182
Cdd:cd22387   79 KRVL 82
KH-I_AtRH42_like cd22475
type I K homology (KH) RNA-binding domain found in Arabidopsis thaliana DEAD-box ATP-dependent ...
 105-182 1.46e-15

type I K homology (KH) RNA-binding domain found in Arabidopsis thaliana DEAD-box ATP-dependent RNA helicase RH42 and similar proteins; RH42, also called DEAD-box RNA helicase RCF1, or REGULATOR OF CBF GENE EXPRESSION 1, is a helicase required for pre-mRNA splicing, cold-responsive gene regulation and cold tolerance. Members in this subfamily contain a divergent KH domain that lacks the RNA-binding GXXG motif.


Pssm-ID: 411903  Cd Length: 102  Bit Score: 71.65  E-value: 1.46e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955529504 105 AEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEkaKVGPGDRPLYLHVQGQTRELVDRAVNRIKEII 182
Cdd:cd22475    7 EELEINDFPQHARWKVTHKDTLGQISELTGAAITTRGQYYPPGR--IPGPGERKLYLLIEGPSEASVKEAKAEIKRIL 82
KH-I_RIK_like_rpt1 cd22471
first type I K homology (KH) RNA-binding domain found in Arabidopsis thaliana protein RIK and ...
 106-182 6.07e-13

first type I K homology (KH) RNA-binding domain found in Arabidopsis thaliana protein RIK and similar proteins; RIK, also called rough sheath 2-interacting KH domain protein, or RS2-interacting KH domain protein, is a RNA binding protein that acts together with RS2/AS1 in the recruitment of HIRA. RIK contains two type I K homology (KH) RNA-binding domains. The model corresponds to the first one. The KH1 domain is a divergent KH domain that lacks the RNA-binding GXXG motif.


Pssm-ID: 411899  Cd Length: 91  Bit Score: 64.03  E-value: 6.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 106 EVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMttEEKAKVGPGDRPLYLHV------QGQTREL---VDRAVN 176
Cdd:cd22471    8 EIVINDAPPSVRHHLTKRSTQDEIQSKTGVVVVTRGRYY--PPGTPPPDNEKPLYLHItagaqlPPDDAERqkaVDAAAA 85


                 ....*.
gi 955529504 177 RIKEII 182
Cdd:cd22471   86 DIQAML 91
KH-I_DDX46 cd22473
type I K homology (KH) RNA-binding domain found in DEAD box protein 46 (DDX46) and similar ...
 106-199 2.05e-10

type I K homology (KH) RNA-binding domain found in DEAD box protein 46 (DDX46) and similar proteins; DDX46, also called PRP5 homolog, is an ATP-dependent RNA helicase that plays an essential role in splicing, either prior to, or during splicing A complex formation. It inhibits antiviral innate responses by entrapping selected antiviral transcripts in the nucleus. It is also involved in the development of several tumors. Members in this subfamily contain a divergent KH domain that lacks the RNA-binding GXXG motif.


Pssm-ID: 411901  Cd Length: 103  Bit Score: 57.33  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 106 EVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKvgPGDRPLYLHVQGQTRELVDRAVNRIKEIITNG 185
Cdd:cd22473    8 ELEINDFPQTARWKVTSKEALAQISEYSEAGITVRGTYFPPGKEPK--EGERKLYLAIEAASERAVQKAKAEITRLIKEE 85

                         90
                 ....*....|....
gi 955529504 186 VVKAATGTSPTFNG 199
Cdd:cd22473   86 LLRLQASYQPINKG 99
KH-I_PRP5_like cd22474
type I K homology (KH) RNA-binding domain found in fungal pre-mRNA-processing ATP-dependent ...
 104-187 2.30e-08

type I K homology (KH) RNA-binding domain found in fungal pre-mRNA-processing ATP-dependent RNA helicase PRP5 and similar proteins; PRP5 is an ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. It catalyzes an ATP-dependent conformational change of U2 snRNP. PRP5 interacts with the U2 snRNP and HSH155. Members in this subfamily contain a divergent KH domain that lacks the RNA-binding GXXG motif.


Pssm-ID: 411902  Cd Length: 89  Bit Score: 51.17  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 104 VAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIIT 183
Cdd:cd22474    6 HAKVEINDLPQKARWEATNNTSLSKIIEETGCSITNKGNFYPPGKEPQPNNDEPKLYLLIEGTTEKAVRLAIELLRRKLV 85


                 ....
gi 955529504 184 NGVV 187
Cdd:cd22474   86 EGVV 89
KH-I_SF1 cd22382
type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar ...
 122-182 4.06e-06

type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar proteins; SF1, also called branch point-binding protein, or BBP, or transcription factor ZFM1, or zinc finger gene in MEN1 locus, or zinc finger protein 162, is necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. It may act as transcription repressor.


Pssm-ID: 411810 [Multi-domain]  Cd Length: 93  Bit Score: 44.61  E-value: 4.06e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 955529504 122 RGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPG------DRPLYLHVQGQTRELVDRAVNRIKEII 182
Cdd:cd22382   26 RGNTLKKIEKETGAKIMIRGKGSVKEGKVGRKDGqplpgeDEPLHALVTANTAESVKKAVDKIKEII 92
KH-I_BBP cd02395
type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) ...
 232-317 7.24e-06

type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) and similar proteins; Yeast BBP, also called mud synthetic-lethal 5 protein, or splicing factor 1, or zinc finger protein BBP, is a mammalian splicing factor SF1 ortholog. It is involved in protein-protein interactions that bridge the 3' and 5' splice-site ends of the intron during the early steps of yeast pre-mRNA splicing. BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC.


Pssm-ID: 411805 [Multi-domain]  Cd Length: 92  Bit Score: 44.13  E-value: 7.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 232 QDKLFVGLEHaVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGS-----GCIEPASGREAFEPMYIYISHPKPEGLA 306
Cdd:cd02395    3 QRKIYIPVDE-YPDYNFIGLIIGPRGNTQKRMEKESGAKIAIRGKGSvkegkGRSDPQPDPDEEEDLHVLITADTEEKVD 81

                         90
                 ....*....|.
gi 955529504 307 AAKKLCENLLQ 317
Cdd:cd02395   82 KAAKLIEKLLI 92
KH-I_SF1 cd22382
type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar ...
 231-317 2.78e-04

type I K homology (KH) RNA-binding domain found in splicing factor 1 (SF1) and similar proteins; SF1, also called branch point-binding protein, or BBP, or transcription factor ZFM1, or zinc finger gene in MEN1 locus, or zinc finger protein 162, is necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. It may act as transcription repressor.


Pssm-ID: 411810 [Multi-domain]  Cd Length: 93  Bit Score: 39.60  E-value: 2.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 231 VQDKLFVGLEHAvPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGS--------GCIEPASGREafEPMYIYISHPKP 302
Cdd:cd22382    2 VSDKVMIPQEEY-PDINFVGLLIGPRGNTLKKIEKETGAKIMIRGKGSvkegkvgrKDGQPLPGED--EPLHALVTANTA 78

                         90
                 ....*....|....*
gi 955529504 303 EGLAAAKKLCENLLQ 317
Cdd:cd22382   79 ESVKKAVDKIKEIIK 93
KH-I_BBP cd02395
type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) ...
 122-182 7.28e-04

type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) and similar proteins; Yeast BBP, also called mud synthetic-lethal 5 protein, or splicing factor 1, or zinc finger protein BBP, is a mammalian splicing factor SF1 ortholog. It is involved in protein-protein interactions that bridge the 3' and 5' splice-site ends of the intron during the early steps of yeast pre-mRNA splicing. BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC.


Pssm-ID: 411805 [Multi-domain]  Cd Length: 92  Bit Score: 38.35  E-value: 7.28e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 955529504 122 RGQTQDEISRLSGAAVSTRGRFMTTEEK----AKVGPGDR-PLYLHVQGQTRELVDRAVNRIKEII 182
Cdd:cd02395   26 RGNTQKRMEKESGAKIAIRGKGSVKEGKgrsdPQPDPDEEeDLHVLITADTEEKVDKAAKLIEKLL 91
KH-I_Hqk cd22465
type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins; ...
 231-278 2.00e-03

type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) and similar proteins; Hqk, also called HqkI, is an RNA-binding protein that plays a central role in myelinization. It binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence and regulates target mRNA stability. It acts by regulating pre-mRNA splicing, mRNA export and protein translation. Hqk is a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia.


Pssm-ID: 411893 [Multi-domain]  Cd Length: 103  Bit Score: 37.61  E-value: 2.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 955529504 231 VQDKLFVGLEhAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGS 278
Cdd:cd22465    2 LQEKLYVPVK-EYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGS 48
KH-I_SPIN1_like cd22467
type I K homology (KH) RNA-binding domain found in Oryza sativa SPL11-interacting protein 1 ...
 244-317 4.62e-03

type I K homology (KH) RNA-binding domain found in Oryza sativa SPL11-interacting protein 1 (SPIN1) and similar proteins; SPIN1 is a K homology domain protein negatively regulated and ubiquitinated by the E3 ubiquitin ligase SPL11. It is involved in flowering time control in rice. SPIN1 binds DNA and RNA in vitro.


Pssm-ID: 411895  Cd Length: 101  Bit Score: 36.32  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 955529504 244 PTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGS----GCIEPASGREAFE----PMYIYISHPKPEG-----LAAAKK 310
Cdd:cd22467   14 PNFNFVGRILGPRGNSLKRVEATTGCRVFIRGRGSikdtAKEEKLRDKPGYEhlnePLHVLIEAELPANiidarLQHAQE 93


                 ....*..
gi 955529504 311 LCENLLQ 317
Cdd:cd22467   94 IIEDLLK 100
KH-I_KHDC4_rpt2 cd22386
first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein ...
 103-175 7.43e-03

first type I K homology (KH) RNA-binding domain found in KH homology domain-containing protein 4 (KHDC4) and similar proteins; KHDC4, also called Brings lots of money 7 (Blom7), or pre-mRNA splicing factor protein KHDC4, is an RNA-binding protein involved in pre-mRNA splicing. It interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. KHDC4 binds preferentially RNA with A/C rich sequences and poly-C stretches. KHDC4 contains two type I K homology (KH) RNA-binding domains. The model corresponds to the second one.


Pssm-ID: 411814 [Multi-domain]  Cd Length: 102  Bit Score: 35.61  E-value: 7.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 955529504 103 VVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGR---FM--TTEEKAkvgpgDRPLYLHVQGQTRELVDRAV 175
Cdd:cd22386    9 VGLEHAPPGFNVRGKLIGPGGSNVKHIQQETGAKVQLRGKgsgFIepASGREA-----DEPLHLLISHPDPEGLQQAK 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH