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Conserved domains on  [gi|966710671|gb|KTG42909|]
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hypothetical protein cypCar_00007499 [Cyprinus carpio]

Protein Classification

7tmA_GPR61_GPR62-like domain-containing protein( domain architecture ID 11606999)

7tmA_GPR61_GPR62-like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
49-365 1.21e-141

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


:

Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 405.30  E-value: 1.21e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  49 SGLVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd15220    1 VGLFCMVLLDLTALVGNTAVMVVIAKTPHLRKFAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYIFLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSG 208
Cdd:cd15220   81 CLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHWSHSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprr 288
Cdd:cd15220  161 HRGVFVVLFALVCFLLPLLLILVVYCGVFKV------------------------------------------------- 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 289 krrtLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15220  192 ----FGGGKAALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIREEL 264
 
Name Accession Description Interval E-value
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
49-365 1.21e-141

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 405.30  E-value: 1.21e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  49 SGLVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd15220    1 VGLFCMVLLDLTALVGNTAVMVVIAKTPHLRKFAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYIFLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSG 208
Cdd:cd15220   81 CLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHWSHSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprr 288
Cdd:cd15220  161 HRGVFVVLFALVCFLLPLLLILVVYCGVFKV------------------------------------------------- 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 289 krrtLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15220  192 ----FGGGKAALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIREEL 264
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-354 2.09e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 139.36  E-value: 2.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671   65 NSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVCGSpFFAGIVFSVLECRLYIFLNAFLISASIFTVTVIS 142
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTniFLLNLAVADLLFGLLTLPFWLVYYL-LHGDWPFGSALCKLVGALFYVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  143 IERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAThCSLHWSHSGH-RRVFAILFCTLC 221
Cdd:pfam00001  81 IDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLLFGWTLTVPEGNVTV-CFIDFPEVLSkPVSYTLLSSVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  222 FCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvRRNQVPRRKRRtlvggKAALT 301
Cdd:pfam00001 160 FLLPLLVILVCYTRIIRTLRKSASKQ---------------------------------KSEERTQRRER-----KALKT 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671  302 LAIIVGQFLLCWLPYFAFHLHLSLGFS--HSTSEEAEGPVT-WLAYSTFAVNPFFY 354
Cdd:pfam00001 202 LAVVVVVFILCWLPYHIVNLLDSLALDceLSRLLDKALSITlWLAYVNSCLNPIIY 257
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
52-237 9.03e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 41.30  E-value: 9.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVV--VKVPHLRKFSLVcHLCIVDLLCAALLmPLGIVcGSPFFAGIvFSVLECRLYIFLNAF 129
Cdd:PHA03087  45 VVYSTIFFFGLVGNIIVIYVLtkTKIKTPMDIYLL-NLAVSDLLFVMTL-PFQIY-YYILFQWS-FGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpSYGSRSSIAATHCSLHW-SHSG 208
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILF---VYTTKKDHETLICCMFYnNKTM 197
                        170       180       190
                 ....*....|....*....|....*....|
gi 966710671 209 HRRVFA-ILFCTLCFCVPAAIIIAVYGNVY 237
Cdd:PHA03087 198 NWKLFInFEINIIGMLIPLTILLYCYSKIL 227
 
Name Accession Description Interval E-value
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
49-365 1.21e-141

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 405.30  E-value: 1.21e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  49 SGLVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd15220    1 VGLFCMVLLDLTALVGNTAVMVVIAKTPHLRKFAFVCHLCVVDLLAALLLMPLGILSSSPFFLGVVFGEAECRVYIFLSV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSG 208
Cdd:cd15220   81 CLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPAPIAARHCSLHWSHSG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprr 288
Cdd:cd15220  161 HRGVFVVLFALVCFLLPLLLILVVYCGVFKV------------------------------------------------- 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 289 krrtLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15220  192 ----FGGGKAALTLAAIVGQFLCCWLPYFAFHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIREEL 264
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
51-358 4.34e-50

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 170.93  E-value: 4.34e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTnyFILNLAVADLLVGLLVIPFSLV--SLLLGRWWFGDALCKLLGFLQS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaaTHCSLHWSHSG 208
Cdd:cd00637   80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGY---CCCCLCWPDLT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSWTMATAHPKRRSdsvnsqttiittstsvrrnqvprr 288
Cdd:cd00637  157 LSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRER------------------------ 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966710671 289 krrtlvggKAALTLAIIVGQFLLCWLPYFAFHL-HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd00637  213 --------KVTKTLLIVVVVFLLCWLPYFILLLlDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
51-363 1.45e-46

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 161.19  E-value: 1.45e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd14967    3 AVFLSLIILVTVFGNLLVILAVYRNRRLRTVTnyFIVSLAVADLLVALLVMPFSAV--YTLLGYWPFGPVLCRFWIALDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGsrSSIAATHCSLHWSHsg 208
Cdd:cd14967   81 LCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDET--QPSVVDCECEFTPN-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 hrRVFAILFCTLCFCVPAAIIIAVYGNVYKVahtAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprr 288
Cdd:cd14967  157 --KIYVLVSSVISFFIPLLIMIVLYARIFRV---ARREL----------------------------------------- 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966710671 289 krrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd14967  191 --------KAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
65-354 2.09e-38

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 425413 [Multi-domain]  Cd Length: 257  Bit Score: 139.36  E-value: 2.09e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671   65 NSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVCGSpFFAGIVFSVLECRLYIFLNAFLISASIFTVTVIS 142
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTniFLLNLAVADLLFGLLTLPFWLVYYL-LHGDWPFGSALCKLVGALFYVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  143 IERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAThCSLHWSHSGH-RRVFAILFCTLC 221
Cdd:pfam00001  81 IDRYLAIVHPLRYRRIRTPRRAKVLILLVWVLALLLSLPPLLFGWTLTVPEGNVTV-CFIDFPEVLSkPVSYTLLSSVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  222 FCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvRRNQVPRRKRRtlvggKAALT 301
Cdd:pfam00001 160 FLLPLLVILVCYTRIIRTLRKSASKQ---------------------------------KSEERTQRRER-----KALKT 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671  302 LAIIVGQFLLCWLPYFAFHLHLSLGFS--HSTSEEAEGPVT-WLAYSTFAVNPFFY 354
Cdd:pfam00001 202 LAVVVVVFILCWLPYHIVNLLDSLALDceLSRLLDKALSITlWLAYVNSCLNPIIY 257
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
51-363 2.94e-35

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 132.07  E-value: 2.94e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKV---PHLRKFS--LVCHLCIVDLLCAALLMPLGIV----CGSPFfaGIVFsvleCR 121
Cdd:cd15051    1 IVLGVVLAVIILLTVIGNVLVCLAVavnRRLRNLTnyFIVSLAVTDLLLGLLVLPFSAIyelrGEWPL--GPVF----CN 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 122 LYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLG-LATVFGW--PSYGSRSSIAAT 198
Cdd:cd15051   75 IYISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSfLPIHLGWntPDGRVQNGDTPN 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 HCSLHWShsghrRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtMATAHPKrrsdsvnsqttiittst 278
Cdd:cd15051  155 QCRFELN-----PPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKR--------INALTPA----------------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 279 svrRNQVPRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHStSEEAEGPVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd15051  205 ---STANSSKSAATAREHKATVTLAAVLGAFIICWFPYFTYFTYRGLCGDNI-NETALSVVLWLGYANSALNPILYAFLN 280

                 ....*
gi 966710671 359 RQIRE 363
Cdd:cd15051  281 RDFRR 285
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
52-365 7.94e-33

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 125.01  E-value: 7.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLnlFLLNLALADLLMSVVGYPLSFY--SNLSGRWSFGDPGCVIYGFAVTF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYeAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGsrSSIAATHCSLHW-SHSG 208
Cdd:cd14969   83 LGLVSISTLAALAFERYLVIVRPLKA-FRLSKRRALILIAFIWLYGLFWALPPLFGWSSYV--PEGGGTSCSVDWySKDP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHtaarergpipswtmatAHPKRRSDSVNSQttiittstsvRRNQVPRR 288
Cdd:cd14969  160 NSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLR----------------KMSKRAARRKNSA----------ITKRTKKA 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 289 KRRTlvggkaALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAeGPVTWL-AYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd14969  214 EKKV------AKMVLVMIVAFLIAWTPYAVVSLYVSFGGESTIPPLL-ATIPALfAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
51-365 2.80e-32

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 123.86  E-value: 2.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVtlnaIALLANSGVLTVVVKVPHLRKF--SLVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd14993    8 VVVFL----LALVGNSLVIAVVLRNKHMRTVtnYFLVNLAVADLLVSLFCMPLTLL--ENVYRPWVFGEVLCKAVPYLQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLG--LATVFGWPSYGSRS--SIAATHCSLHW 204
Cdd:cd14993   82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMlpLLVVYELEEIISSEpgTITIYICTEDW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGHRRVFAILFCTLCFCVPAAIIIAVYGNV-YKVahtaarergpipsWTMATAHPKRRSDSVNSqttiittstsvRRN 283
Cdd:cd14993  162 PSPELRKAYNVALFVVLYVLPLLIISVAYSLIgRRL-------------WRRKPPGDRGSANSTSS-----------RRI 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 QVPRRkrrtlvggKAALTLAIIVGQFLLCWLPYFAfhLHLSLGFSHSTSEEAEGPV-------TWLAYSTFAVNPFFYGL 356
Cdd:cd14993  218 LRSKK--------KVARMLIVVVVLFALSWLPYYV--LSILLDFGPLSSEESDENFllilpfaQLLGYSNSAINPIIYCF 287

                 ....*....
gi 966710671 357 LNRQIREEL 365
Cdd:cd14993  288 MSKKFRRGF 296
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
52-362 6.28e-32

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 122.05  E-value: 6.28e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIV---CGSPFFAGIVfsvleCRLYIFL 126
Cdd:cd15064    5 VLLSLIILATILGNALVIAAILLTRKLHTPAnyLIASLAVADLLVAVLVMPLSAVyelTGRWILGQVL-----CDIWISL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWpsyGSRSSIAATHCSLHWSH 206
Cdd:cd15064   80 DVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGW---RTPDSEDPSECLISQDI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SghrrvFAIlFCTLC-FCVPAAIIIAVYGNVYkvaHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqv 285
Cdd:cd15064  157 G-----YTI-FSTFGaFYIPLLLMLILYWKIY---RAAARER-------------------------------------- 189
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 286 prrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15064  190 -----------KAAKTLGIILGAFIVCWLPFFLVALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFR 255
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
51-359 5.22e-30

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 117.66  E-value: 5.22e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKF-----SLVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRLY 123
Cdd:cd15055    1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLhtptnLLLLSLAVADFLVGLLVMPFSMIrsIETCWYFGDTF----CKLH 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpSYGSRSSIAAT----- 198
Cdd:cd15055   77 SSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLY---DNLNQPGLIRYnscyg 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 HCSLHWSHSghrrvFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGpipswTMATAHPKRRSdsvnsqttiittst 278
Cdd:cd15055  154 ECVVVVNFI-----WGVVDLVLTFILPCTVMIVLYMRIFVVARSQARAIR-----SHTAQVSLEGS-------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 279 svrRNQVPRRKRRtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAegpVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd15055  210 ---SKKVSKKSER-----KAAKTLGIVVGVFLLCWLPYYIVSLVDPYISTPSSVFDV---LIWLGYFNSCLNPLIYALFY 278

                 .
gi 966710671 359 R 359
Cdd:cd15055  279 P 279
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
51-362 6.74e-29

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 114.83  E-value: 6.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLnaiALLANSGVLTVVVKVPHLRKF---SLVCHLCIVDLLCAALLMP---LGIVCGSPFFAGIvfsvleCRLYI 124
Cdd:cd15057    7 LYLLVLL---TLLGNALVIAAVLRFRHLRSKvtnYFIVSLAVSDLLVAILVMPwaaVNEVAGYWPFGSF------CDVWV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATV-FGWPSYGSRSS---IAATHC 200
Cdd:cd15057   78 SFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVqLGWHRADDTSEalaLYADPC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSHSghrRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpkRRSDSVNSqttiittstSV 280
Cdd:cd15057  158 QCDSSLN---RTYAISSSLISFYIPVAIMIVTYTRIYRIARRQI-----------------RRIAALER---------AA 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 281 RRNQVPRRKRRTLVGG--KAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHST-----SEEAEGPVTWLAYSTFAVNPFF 353
Cdd:cd15057  209 QESTNPDSSLRSSLRRetKALKTLSIIMGVFVCCWLPFFILNCVLPFCDLRTAqfpcvPDTTFIVFVWLGWANSSLNPII 288

                 ....*....
gi 966710671 354 YGlLNRQIR 362
Cdd:cd15057  289 YA-FNADFR 296
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
51-365 1.73e-27

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 110.77  E-value: 1.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVtlnaIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLM--------PLGIVCGSPFFAGIVfsvleCRL 122
Cdd:cd15203    8 GLIIV----LGVVGNLLVIYVVLRNKSMQT---VTNIFILNLAVSDLLLclvslpftLIYTLTKNWPFGSIL-----CKL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 123 YIFLNAFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGL-----ATVFGWPSYGSRSSIaa 197
Cdd:cd15203   76 VPSLQGVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLplaifQELSDVPIEILPYCG-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 THCSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTaarergpipSWTMATAHPKRRSDsvnsqttiitts 277
Cdd:cd15203  152 YFCTESWPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRK---------RVKKKRGKRTLSSR------------ 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 278 tsvRRNQVPRRKRRTLvggkaaLTLAIIVGQFLLCWLPYFAFHL----HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFF 353
Cdd:cd15203  211 ---RRRSELRRKRRTN------RLLIAMVVVFAVCWLPLNLFNLlrdfEPLPQIDGRHFYLIFLICHLIAMSSACVNPLL 281
                        330
                 ....*....|..
gi 966710671 354 YGLLNRQIREEL 365
Cdd:cd15203  282 YGWLNDNFRKEF 293
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
52-363 6.31e-27

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 108.51  E-value: 6.31e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIV-----DLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFL 126
Cdd:cd15329    2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVslavsDLLVALLVMPLAII--YELSGYWPFGEILCDVWISF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSrssiAATHCSLhwsh 206
Cdd:cd15329   80 DVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNKVN----DPGVCQV---- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SGHrRVFAIlFCTLC-FCVPAAIIIAVYGNVYKVAHtaaRERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqv 285
Cdd:cd15329  152 SQD-FGYQI-YATFGaFYIPLIVMLVLYYKIYRAAK---SER-------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 286 prrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSE---EAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15329  189 -----------KAIKTLGIIMGAFTLCWLPFFILALLRPFLKPIKCSCiplWLSRLFLWLGYANSFLNPIIYAKFNREFR 257

                 .
gi 966710671 363 E 363
Cdd:cd15329  258 T 258
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
52-363 1.28e-26

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 108.55  E-value: 1.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRLYIFLN 127
Cdd:cd15048    5 VLISVLILVTVIGNLLVILAFIKDKKLRTVSnfFLLNLAVADFLVGLVSMPFYIPytLTGKWPFGKVF----CKAWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSL----H 203
Cdd:cd15048   81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIVPTGDCEVeffdH 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WshsghrrVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERgPIPSWTMATAHPKRRSDSVNsqttiittstsvrRN 283
Cdd:cd15048  161 F-------YFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRR-PLRSVPILPASQNPSRARSQ-------------RE 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 QVPRRKRRtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15048  220 QVKLRRDR-----KAAKSLAILVLVFLICWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
65-365 3.47e-26

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 106.94  E-value: 3.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  65 NSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVIS 142
Cdd:cd15207   18 NVLVCLVVAKNPRMRTvtNYFILNLAVSDLLVGVFCMPFTLV--DNILTGWPFGDVMCKLSPLVQGVSVAASVFTLVAIA 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 143 IERYFYIVHPMryEAKMTPWLSAAVMGFVWVAS--TLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGHRRVFAILFCTL 220
Cdd:cd15207   96 VDRYRAVVHPT--EPKLTNRQAFVIIVAIWVLAlaIMIPQALVLEVKEYQFFRGQTVHICVEFWPSDEYRKAYTTSLFVL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 221 CFCVPAAIIIAVYGNV-YKVAHTaarergpipswtmatahPKRRSDSVNSQttiittstsvRRNQVPRRKRRTLVggkaa 299
Cdd:cd15207  174 CYVAPLLIIAVLYVRIgYRLWFK-----------------PVPGGGSASRE----------AQAAVSKKKVRVIK----- 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 300 lTLAIIVGQFLLCWLPYfafHLHLSLG-FSHSTSEEAEG------PVT-WLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15207  222 -MLIVVVVLFALSWLPL---HTVTMLDdFGNLSPNQREVlyvyiyPIAhWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
53-362 5.07e-26

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 105.91  E-value: 5.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15061    5 FLILAIIFTIFGNLLVILAVATTRRLRTITncYIVSLATADLLVGVLVLPLAII--RQLLGYWPLGSHLCDFWISLDVLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRssiaaTHCSLHWSHSGHR 210
Cdd:cd15061   83 CTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRR-----GLGSCYYTYDKGY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 211 RVFAILfctLCFCVPAAIIIAVYGNVYKVAHtaaRERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkr 290
Cdd:cd15061  158 RIYSSM---GSFFLPLLLMLFVYLRIFRVIA---KER------------------------------------------- 188
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966710671 291 rtlvggKAALTLAIIVGQFLLCWLPYFAFhlHLSLGFSHST-SEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15061  189 ------KTAKTLAIVVGCFIVCWLPFFIM--YLIEPFCDCQfSEALSTAFTWLGYFNSVINPFIYAFYNKDFR 253
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
50-354 8.41e-26

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 106.38  E-value: 8.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  50 GLVVMVTLnaiallanSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVcgsPFFAGIV------FSVLECRLY 123
Cdd:cd15058    8 ALIILAIV--------VGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVV---PLGATIVvtgkwqLGNFWCELW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF----------GWPSYGSrs 193
Cdd:cd15058   77 TSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMnqwwrandpeANDCYQD-- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 194 siaATHCSLHWShsghrRVFAILFCTLCFCVPAAIIIAVYGNVYKVahtAARERGPIpswtmatahpKRRSDSVNSQTTI 273
Cdd:cd15058  155 ---PTCCDFRTN-----MAYAIASSVVSFYIPLLIMIFVYARVFLI---ATRQLQLI----------DKRRLRFQSECPA 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 274 ITTSTSVRRNQVPRRKRRTLV--GGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSeEAEGPVTWLAYSTFAVNP 351
Cdd:cd15058  214 PQTTSPEGKRSSGRRPSRLTVvkEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPG-EVFLLLNWLGYINSGLNP 292

                 ...
gi 966710671 352 FFY 354
Cdd:cd15058  293 IIY 295
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
62-356 3.94e-25

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 104.70  E-value: 3.94e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  62 LLANSGVLTVVVKVPHLR-KFS--LVCHLCIVDLLCAALLMPLGIVCGspfFAGIVFSVLECRLYIFLNAFLISASIFTV 138
Cdd:cd15320   16 LLGNTLVCAAVIRFRHLRsKVTnfFVISLAVSDLLVAVLVMPWKAVAE---IAGFWPFGSFCNIWVAFDIMCSTASILNL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 139 TVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATV-FGW----PSYGSRSSIAATHCSLHWSHSGHRRVF 213
Cdd:cd15320   93 CVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqLNWhkakPTSFLDLNASLRDLTMDNCDSSLNRTY 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 214 AILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpIPSWTMATAHPKRRSDSVNSQTTIittstsvrRNQVPRR----- 288
Cdd:cd15320  173 AISSSLISFYIPVAIMIVTYTRIYRIAQKQIRR---ISALERAAVHAKNCQNSTGNRGSG--------DCQQPESsfkms 241
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 289 -KRRTlvggKAALTLAIIVGQFLLCWLPYFAfhLHLSLGFSHSTSEEAE--GPVT-----WLAYSTFAVNPFFYGL 356
Cdd:cd15320  242 fKRET----KVLKTLSVIMGVFVCCWLPFFI--LNCMVPFCKPTSTEPFciSSTTfdvfvWFGWANSSLNPIIYAF 311
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
57-365 8.41e-25

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 103.09  E-value: 8.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  57 LNAIALLANSGVLTVVVKVPHLRKF-----SLVCHLCIVDLLCAALLMPLGIV-----CgspFFAGIVFsvleCRLYIFL 126
Cdd:cd15314    7 LGLISLVTVCGNLLVIISIAHFKQLhtptnYLILSLAVADLLVGGLVMPPSMVrsvetC---WYFGDLF----CKIHSSF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFG----WPSYGSRSSiAATHCSL 202
Cdd:cd15314   80 DITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLelniKGIYYNHVA-CEGGCLV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHsghrrVFAILFCTLCFCVPAAIIIAVYGNVYKVAhtaarergpipswtmatahpKRRSDSVNSQttiittstSVRR 282
Cdd:cd15314  159 FFSK-----VSSVVGSVFSFYIPAVIMLCIYLKIFLVA--------------------QRQARSIQSA--------RTKS 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 NQVPRRKRRtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLgFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15314  206 GASSSKMER-----KATKTLAIVMGVFLLCWTPFFLCNIIDPF-INYSIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFR 279

                 ...
gi 966710671 363 EEL 365
Cdd:cd15314  280 KAF 282
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
59-363 1.12e-24

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 103.20  E-value: 1.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIF 136
Cdd:cd15065   11 VLAIFGNVLVCLAIFTDRRLRKKSnlFIVSLAVADLLVALLVMTFAVV--NDLLGYWLFGETFCNIWISFDVMCSTASIL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 137 TVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF-GW------PSYGSRSSIAATHCSLHWSHSgh 209
Cdd:cd15065   89 NLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHlGWhrlsqdEIKGLNHASNPKPSCALDLNP-- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 rrVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpIPSWTMaTAHPKRRSDSVNSQTTiittstsvRRNQVPRrk 289
Cdd:cd15065  167 --TYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVN---IKSQKL-PSESGSKFQVPSLSSK--------HNNQGVS-- 230
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 290 rrtlvGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLgFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15065  231 -----DHKAAVTLGIIMGVFLICWLPFFIINIIAAF-CKTCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFRR 298
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
51-363 1.23e-24

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 102.37  E-value: 1.23e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLC-AALLMPLGIVCGSPFFAGIVFSVLecRLYIFLN 127
Cdd:cd14972    2 LVVAIVLGVFIVVENSLVLAAIIKNRRLHKpmYILIANLAAADLLAgIAFVFTFLSVLLVSLTPSPATWLL--RKGSLVL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLisASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGS-RSSIAATHCSLHWSH 206
Cdd:cd14972   80 SLL--ASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLGWNCVLCdQESCSPLGPGLPKSY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 sghrrvfaILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtMATAHPKrrsdsvnsqttiittstsvrrnQVP 286
Cdd:cd14972  158 --------LVLILVFFFIALVIIVFLYVRIFWCLWRHANA--------IAARQEA----------------------AVP 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 287 RRKRRTLvggKAALTLAIIVGQFLLCWLPYFAfhlHLSLGFSHSTSEEAEGPVTW---LAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd14972  200 AQPSTSR---KLAKTVVIVLGVFLVCWLPLLI---LLVLDVLCPSVCDIQAVFYYflvLALLNSAINPIIYAFRLKEMRR 273
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
62-358 1.39e-23

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 99.74  E-value: 1.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  62 LLANSGVLTVVVKVPHLRKFS-----LVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRLYIFLNAFLISAS 134
Cdd:cd15312   12 LLTVFGNLMVIISISHFKQLHsptnfLILSLAITDFLLGFLVMPYSMVrsVESCWYFGDLF----CKIHSSLDMMLSTTS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 135 IFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF------GWPSYGSRSSIAAThCSLHWShsg 208
Cdd:cd15312   88 IFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFsevnleGIEDYVALVSCTGS-CVLIFN--- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 hrRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtMATAHPKRRSDSvnsqttiittstsvrRNQVPRR 288
Cdd:cd15312  164 --KLWGVIASLIAFFIPGTVMIGIYIKIFFVARKHAKV--------INNRPSVTKGDS---------------KNKLSKK 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966710671 289 KRRtlvggKAALTLAIIVGQFLLCWLPYF-AFHLHLSLGFshSTSEEAEGPVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd15312  219 KER-----KAAKTLSIVMGVFLLCWLPFFvATLIDPFLNF--STPVDLFDALVWLGYFNSTCNPLIYGFFY 282
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
51-365 1.85e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 99.76  E-value: 1.85e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLlCAALLMPLGIVCGSPFFAGIVFSVLeCRLYIFLNA 128
Cdd:cd14986    4 VAVLGVLFVFTLVGNGLVILVLRRKRkkRSRVNIFILNLAIADL-VVAFFTVLTQIIWEATGEWVAGDVL-CRIVKYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKmtPWLSAAVMGFVWVASTLLGLATVFGWpsYGSRSSIAATHCSLHWSHSG 208
Cdd:cd14986   82 VGLFASTYILVSMSLDRYQAIVKPMSSLKP--RKRARLMIVVAWVLSFLFSIPQLVIF--VERELGDGVHQCWSSFYTPW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSwtmatAHPKRRSDSVNsqttiittSTSVRRNQVPRR 288
Cdd:cd14986  158 QRKVYITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPI-----APTAMSCRSVS--------CVSSRVSLISRA 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 289 KRRTLvggkaALTLAIIVGqFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd14986  225 KIKTI-----KMTLVIILA-FILCWTPYFIVQLLDVYAGMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
49-362 4.31e-22

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 94.81  E-value: 4.31e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  49 SGLVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVCgspFFAG-IVFSVLECRLYIF 125
Cdd:cd15060    2 VTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQnfFIVSLAVADLAVAIFVLPLNVAY---FLLGkWLFGIHLCQMWLT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYgSRSSIAATHCSLhws 205
Cdd:cd15060   79 CDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDW-PENFTETTPCTL--- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 206 hsGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKvahTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqv 285
Cdd:cd15060  155 --TEEKGYVIYSSSGSFFIPLLIMTIVYVKIFI---ATSKER-------------------------------------- 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 286 prrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15060  192 -----------RAARTLGIIMGVFVVCWLPFFLMYVILPFCETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFR 257
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
59-363 5.92e-22

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 94.75  E-value: 5.92e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLgivCGSPFFAGI------VFSVLECRLYIFLNAFLIS 132
Cdd:cd15066    8 LIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVAL---CAMTFNASVeitgrwMFGYFMCDVWNSLDVYFST 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF-GWPSYGSRSSIAATH---CSLHWShsg 208
Cdd:cd15066   85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFlGWYTTEEHLQYRKTHpdqCEFVVN--- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 hrRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHtaaRERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprr 288
Cdd:cd15066  162 --KIYALISSSVSFWIPCIVMIFTYYRIYLEAK---REH----------------------------------------- 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 289 krrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSL-GFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15066  196 --------KAAKTLGIIMGAFILCWLPFFLWYVTTTLcGDACPYPPILVSILFWIGYFNSTLNPLIYAYFNRDFRE 263
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
51-362 1.85e-21

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 93.32  E-value: 1.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVcgsPFFAGI------VFSVLECRLYI 124
Cdd:cd15062    1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVL---PFSATLevlgywAFGRIFCDVWA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPsygSRSSIAATHCSLhw 204
Cdd:cd15062   78 AVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWK---EPAPADEQACGV-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 shsgHRRVFAILFCTLC-FCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrn 283
Cdd:cd15062  153 ----NEEPGYVLFSSLGsFYLPLAIILVMYCRVYVVAFKFSREK------------------------------------ 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 qvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFafhLHLSLGFSHSTSEEAEGP---VTWLAYSTFAVNPFFYGLLNRQ 360
Cdd:cd15062  193 -------------KAAKTLGIVVGAFVLCWFPFF---VVLPLGSLFSTLKPPEPVfkvVFWLGYFNSCLNPIIYPCSSRE 256

                 ..
gi 966710671 361 IR 362
Cdd:cd15062  257 FK 258
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
87-363 5.99e-21

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 91.63  E-value: 5.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIV---CGSPFFAGIVfsvleCRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWL 163
Cdd:cd15059   42 LAVADILVGLLIMPFSLVnelMGYWYFGSVW-----CEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 164 SAAVMGFVWVASTLLGLATVFGWPSyGSRSSIAATHCSLHwSHSGHrrvfaILF-CTLCFCVPAAIIIAVYGNVYKVahT 242
Cdd:cd15059  117 AKAMIAAVWIISAVISLPPLFGWKD-EQPWHGAEPQCELS-DDPGY-----VLFsSIGSFYIPLLIMIIVYARIYRA--A 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 243 AARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkRRTLVggkaaltLAIIVGQFLLCWLPYFAFHLH 322
Cdd:cd15059  188 KRKER------------------------------------------RFTLV-------LGVVMGAFVLCWLPFFFTYPL 218
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 966710671 323 LSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15059  219 VVVCKTCGVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRR 259
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
52-362 7.79e-21

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 91.26  E-value: 7.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGI---VCGSPFFagivFSVLECRLYIFL 126
Cdd:cd15067    4 VVLSLFCLVTVAGNLLVILAVLRERYLRTVTnyFIVSLAVADLLVGSIVMPFSIlheMTGGYWL----FGRDWCDVWHSF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiAATHCsLHWSH 206
Cdd:cd15067   80 DVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPS-PPNQC-LFTDD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SGHRrvfaILFCTLCFCVPAAIIIAVYGNVYKvahTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvp 286
Cdd:cd15067  158 SGYL----IFSSCVSFYIPLVVMLFTYYRIYR---AAAKEQ--------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 287 rrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFhlHLSLGFSHSTSEEAEGP----VTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15067  192 ----------KAAKTLGIVMGVFILCWLPFFVT--NILIGFCPSNCVSNPDIlfplVTWLGYINSGMNPIIYACSSRDFR 259
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
52-365 8.48e-21

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 92.01  E-value: 8.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLR--KFSLVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIYAFCRFKSLRtpANYLIINLAISDFLMCILNCPLMVI--SSFSGRWIFGKTGCDMYGFSGGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIaaTHCSLHW-SHSG 208
Cdd:cd15083   83 FGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLL--TSCSFDYlSRDD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpKRRSDSVNSQTtiittstsvRRNQVPRR 288
Cdd:cd15083  161 ANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEKAM-------------KEMAKRFSKSE---------LSSPKARR 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 289 KRRTlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15083  219 QAEV----KTAKIALLLVLLFCLAWTPYAVVALIGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
51-362 9.18e-21

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 91.11  E-value: 9.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVcgsPFFAGI------VFSVLECRLYI 124
Cdd:cd15326    1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVL---PFSATLeilgywVFGRIFCDIWA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaaTHCSLhw 204
Cdd:cd15326   78 AVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDD---KVCEI-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 shsgHRRVFAILFCTL-CFCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrn 283
Cdd:cd15326  153 ----TEEPFYALFSSLgSFYIPLIVILVMYCRVYIVALKFSREK------------------------------------ 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 qvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFaFHLHLSLGFSHSTSEEA-EGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15326  193 -------------KAAKTLGIVVGMFILCWLPFF-IALPLGSLFSHLKPPETlFKIIFWLGYFNSCLNPIIYPCSSKEFK 258
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
51-362 1.14e-20

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 91.02  E-value: 1.14e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVcgsPFFAGI------VFSVLECRLYI 124
Cdd:cd15063    1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVL---PFSAVNevldvwIFGHTWCQIWL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHW 204
Cdd:cd15063   78 AVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPC 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 S-HSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpkrrsdsvnsqttiittstsvrrn 283
Cdd:cd15063  158 TcELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARMET--------------------------------------- 198
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 284 qvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15063  199 -------------KAAKTVAIIVGCFIFCWLPFFTVYL-VRAFCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
51-363 1.16e-20

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 90.78  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLA---NSGVLTVVV---KVPHLRKFsLVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRL 122
Cdd:cd15334    1 ILISLTLSILALMTtaiNSLVITAIIvtrKLHHPANY-LICSLAVTDFLVAVLVMPFSIMyiVKETWIMGQVV----CDI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 123 YIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgWPSYGSRSSiaaTHCSL 202
Cdd:cd15334   76 WLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLF-WRHQTTSRE---DECII 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHSghrrVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrr 282
Cdd:cd15334  152 KHDHI----VFTIYSTFGAFYIPLALILILY---YKIYRAATRER----------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 nqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15334  190 --------------KAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFK 255

                 .
gi 966710671 363 E 363
Cdd:cd15334  256 K 256
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
55-365 2.22e-20

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 90.00  E-value: 2.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  55 VTLNAIALLANSGVLTVVV---KVPHLRKFS--LVCHLCIVDLLCAALLMPLgiVCGSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15214    4 IAIIIIAILICLGNLVIVVtlyKKSYLLTLSnkFVFSLTLSNLLLSVLVLPF--VVTSSIRREWIFGVVWCNFSALLYLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWpsygsrSSIAATH----CSLHWS 205
Cdd:cd15214   82 ISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGW------SSLEFDRfkwmCVAAWH 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 206 HSGHRRVFAILFCTLcfcVPAAIIIAVYGNVYKVAhtaarergpipswtmatahpkrrsdsvnsqttiittstsvRRNQV 285
Cdd:cd15214  156 KEAGYTAFWQVWCAL---LPFVVMLVCYGFIFRVA----------------------------------------RANQC 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 286 prrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15214  193 -----------KAFITILVVLGAFVTTWGPYMVVISTEALWGKNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
60-362 4.12e-20

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 89.86  E-value: 4.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRLYIFLNAFLISASI 135
Cdd:cd15056   13 LTILGNLLVIVAVCTDRQLRKKTnyFVVSLAVADLLVAVLVMPFGAIelVNNRWIYGETF----CLVRTSLDVLLTTASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 136 FTVTVISIERYFYIVHPMRYEaKMTPWLSAAVMGFVWVASTLLGLATVF-GWPSYGSRSSIA------ATHCSLHWShsg 208
Cdd:cd15056   89 MHLCCIALDRYYAICCQPLVY-KMTPLRVAVMLGGCWVIPTFISFLPIMqGWNHIGIEDLIAfncasgSTSCVFMVN--- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 hrRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpIPSWTMATAHPKRRSDSVNSqttiittstsvrrnqvpRR 288
Cdd:cd15056  165 --KPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQ---IRSLQRAGSSNHEADQHRNS-----------------RM 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 289 KRRTlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLgFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15056  223 RTET----KAAKTLGIIMGCFCVCWAPFFVTNIVDPF-IGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFR 291
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
62-356 5.93e-20

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 90.02  E-value: 5.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  62 LLANSGVLTVVVKVPHLRKFS---LVCHLCIVDLLCAALLMPLGIVCGS----PFFAGivfsvleCRLYIFLNAFLISAS 134
Cdd:cd15319   15 LLGNILVCAAVVRFRHLRSKVtniFIVSLAVSDLFVALLVMPWKAVAEVagywPFGAF-------CDVWVAFDIMCSTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 135 IFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATV-FGWPSYGSRSSIAATHCSLHWSHSGH---- 209
Cdd:cd15319   88 ILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVqLNWHKDSGDDWVGLHNSSISRQVEENcdss 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 -RRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpIPSWTMATAHPKR-RSDSVNSQTTIITTSTSVRRNQVPR 287
Cdd:cd15319  168 lNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIRR---ISSLERAAEHAQScRSNRIDCHHHTSLRTSIKKETKVLK 244
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 288 rkrrtlvggkaalTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPV---------TWLAYSTFAVNPFFYGL 356
Cdd:cd15319  245 -------------TLSVIMGVFVCCWLPFFILNCMVPFCDRPPADPDAGLPCvsettfdvfVWFGWANSSLNPIIYAF 309
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
53-362 8.29e-20

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 88.43  E-value: 8.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVcgsPFFAGI------VFSVLECRLYIFL 126
Cdd:cd15327    3 VGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVL---PFSATLevlgfwAFGRVFCDIWAAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGW----PSYGSRSSIAathcsl 202
Cdd:cd15327   80 DVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWkeppPPDESICSIT------ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 hwSHSGHrrvfaILFCTLC-FCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvr 281
Cdd:cd15327  154 --EEPGY-----ALFSSLFsFYLPLMVILVMYFRVYVVALKFSREK---------------------------------- 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 282 rnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFaFHLHLSLGF-SHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQ 360
Cdd:cd15327  193 ---------------KAAKTLAIVVGVFILCWFPFF-FVLPLGSFFpALKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKE 256

                 ..
gi 966710671 361 IR 362
Cdd:cd15327  257 FK 258
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
51-356 1.33e-19

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 88.66  E-value: 1.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS-----LVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRLY 123
Cdd:cd15317    1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHsptnmLVLSLATADFLLGLCVMPFSMIrtVETCWYFGDLF----CKFH 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF------GWPSYGSRSSIAA 197
Cdd:cd15317   77 TGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYtgandeGLEEYSSEISCVG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 ThCSLHWSHsghrrvFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtMATAHPKRRSDSVNSQTTiitts 277
Cdd:cd15317  157 G-CQLLFNK------IWVLLDFLTFFIPCLIMIGLYAKIFLVARRQARK--------IQNMEDKFRSSEENSSKA----- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 278 tsvrrnqVPRRKRrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSlgFSH-STSEEAEGPVTWLAYSTFAVNPFFYGL 356
Cdd:cd15317  217 -------SASRER------KAAKTLAIVMGIFLFCWLPYFIDTIVDE--YSNfITPAIVFDAVIWLGYFNSAFNPFIYAF 281
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
52-362 4.13e-19

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 86.96  E-value: 4.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMPLGIvcgsPFFAGIV------FSVLECRLYIF 125
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIYVILRYSKMKT---VTNIYILNLAVADELFLLGL----PFLATSYllgywpFGEVMCKIVLS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpsYGS--RSSIAATHCSLH 203
Cdd:cd14970   78 VDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVII----FARtlQEEGGTISCNLQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WSHSGH--RRVFAILFCTLCFCVPAAIIIAVYGNVYKvahtAARERGPIPSWtmaTAHPKRRSdsvnsqttiittstsvr 281
Cdd:cd14970  154 WPDPPDywGRVFTIYTFVLGFAVPLLVITVCYSLIIR----RLRSSRNLSTS---GAREKRRA----------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 282 rnqvpRRKRRTLVggkaaltlAIIVGQFLLCWLPYFAFHL-HLSLGFSHSTSEEAEG-PVTWLAYSTFAVNPFFYGLLNR 359
Cdd:cd14970  210 -----RRKVTRLV--------LVVVAVFVVCWLPFHVFQIvRLLIDPPETLTVVGVFlFCIALSYANSCLNPILYAFLDE 276

                 ...
gi 966710671 360 QIR 362
Cdd:cd14970  277 NFR 279
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
60-365 5.82e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 86.61  E-value: 5.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFSlvcHLCIVDLlcAALLMPLGIVCGSP------FFAGIVFSVLECRLYIFLNAFLISA 133
Cdd:cd15337   13 LGVIGNLLVIYLFSKTKSLRTPS---NMFIINL--AISDFGFSAVNGFPlktissFNKKWIWGKVACELYGFAGGIFGFM 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSY---GSRSSiaathCSLHW-SHSGH 209
Cdd:cd15337   88 SITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYvpeGFQTS-----CTFDYlSRDLN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswTMATAHPKRRSDSVNSQttiittstsvrrnqvpRRK 289
Cdd:cd15337  163 NRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHEKE-------MTQTAKSGMGKDTEKND----------------ARK 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 290 RRTLvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHS-TSEEAEGPVTwLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15337  220 KAEI---RIAKVAIILISLFLLSWTPYAVVALLGQFGPAYWiTPYVSELPVM-FAKASAIYNPIIYALSHPKFRAAL 292
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
60-365 6.04e-19

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 86.56  E-value: 6.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKF--SLVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15074   13 LSTLGNGTVLFVLYRRRSKLKPaeLLTVNLAVSDLGISVFGYPLAII--SAFAHRWLFGDIGCVFYGFCGFLFGCCSINT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPmRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRssIAATHCSLHWSHSGHRR---VFA 214
Cdd:cd15074   91 LTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALFWAVAPLVGWGSYGPE--PFGTSCSIDWTGASASVggmSYI 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 215 ILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtmatahpkrrsdsvnsqttiittstsvRRNQVPRRKRRTLV 294
Cdd:cd15074  168 ISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKR----------------------------------VAGFDSRSKRQHKI 213
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966710671 295 GGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15074  214 ERKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSPDSVPILASILPALFAKSSCMYNPIIYLLFSSKFRQDL 284
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
48-365 8.17e-19

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 85.59  E-value: 8.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  48 MSGLVVMVTlnAIALLANSGVLTVVVKVPHLRKFS---LVCHLCIVDLLCAALLMP---LGIVCGSPFFAGIVfsvleCR 121
Cdd:cd15219    2 LAVLLVVVL--VVSLLSNLLVLLCFLYSAELRKQVpgiFLLNLSFCNLLLTVLNMPftlLGVVRNRQPFGDGF-----CQ 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 122 LYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVAS-TLLGLATVFGWPSYgsrSSIAAThC 200
Cdd:cd15219   75 AVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSlTFSLVALFLSWLGY---SSLYAS-C 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSHSGHRR---VFAILFCTLCFCVPAAIIIAVYGNVYKvahtaarergpipswtmatahpkrrsdsvnsqttiitts 277
Cdd:cd15219  151 TLHLPREEERRrfaVFTAFFHAFTFLLSLLVLCVTYLKVLK--------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 278 tsVRRNQVPRRKrrtlvggkaaltLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEeaEGPVT-WLAYSTFAVNPFFYGL 356
Cdd:cd15219  192 --VRRRQRATKK------------ISIFIGTFVLCFAPYVITRLVELLPFVTINRY--WGIVSkCLTYSKAASDPFVYSL 255

                 ....*....
gi 966710671 357 LNRQIREEL 365
Cdd:cd15219  256 LRQQYRKVL 264
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
56-362 8.63e-19

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 85.42  E-value: 8.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  56 TLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISA 133
Cdd:cd15330    9 TLILCAIFGNACVVAAIALERSLQNVAnyLIGSLAVTDLMVSVLVLPMAAL--YQVLNKWTLGQVTCDLFIALDVLCCTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAthCSLHWSHSghrrvF 213
Cdd:cd15330   87 SILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDA--CTISKDPG-----Y 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 214 AILFCTLCFCVPAAIIIAVYGNVYKvahTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrrtl 293
Cdd:cd15330  160 TIYSTFGAFYIPLILMLVLYGRIFK---AAARER---------------------------------------------- 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 294 vggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPV-TWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15330  191 ---KTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHMPELLGAIiNWLGYSNSLLNPIIYAYFNKDFQ 257
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
51-358 1.51e-18

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 84.98  E-value: 1.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLA---NSGVLTVV--VKVPHLRKFSLVCHLCIVDLLCAALLMPLGI--VCGSPFFAGIVFsvleCRLY 123
Cdd:cd15335    1 MLIVLTLALITILTtvlNSAVIAAIctTKKLHQPANYLICSLAVTDFLVAVLVMPLSItyIVMDTWTLGYFI----CEIW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgWPSYGsrSSIAATHCSLH 203
Cdd:cd15335   77 LSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLF-WRNHH--DANIPSQCIIQ 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WSHSGHrrvfaILFCTL-CFCVPAAIIIAVYgnvYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrr 282
Cdd:cd15335  154 HDHVIY-----TIYSTFgAFYIPLTLILILY---YRIYHAASRER----------------------------------- 190
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 283 nqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGpVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd15335  191 --------------KAARILGLILGAFILSWLPFFIKELIVGLSVMTVSPEVADF-LTWLGYVNSLVNPLLYTSFN 251
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
51-363 2.47e-18

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 84.52  E-value: 2.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAI-ALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMPLgivCGSP----------FFAGIVFSVLE 119
Cdd:cd15085    3 LSFLMFLNATfSIFNNVLVIAVTLKNPQLRN---PINIFILNLSFSDLMMAL---CGTTivtvtnyegyFYLGDAFCIFQ 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CrlyIFLNAFLIsASIFTVTVISIERYFYIVHPMRyEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSsiAATH 199
Cdd:cd15085   77 G---FAVNYFGI-VSLWSLTLLAYERYNVVCKPMG-GLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEG--VQTS 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 200 CSLHWSHSGHRRV-FAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARergpipswtmatahpkrrsdSVNSQTTiittst 278
Cdd:cd15085  150 CSIGWEERSWSNYsYLILYFLMCFVIPVAIIGFSYGNVLRSLHKLNK--------------------KIEQQGG------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 279 svrrNQVPRRKRRTLVggkaaLTLAIIVGqFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd15085  204 ----KNCPEEEERAVI-----MVLAMVIA-FLICWLPYTVFALIVVVNPELSISPLAATMPTYFAKTSPVYNPIIYIFLN 273

                 ....*
gi 966710671 359 RQIRE 363
Cdd:cd15085  274 KQFRE 278
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
48-354 2.75e-18

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 84.96  E-value: 2.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  48 MSGLVVMVTLNAIaLLANSGVLTVVVKVPHLRKFSLVChlcIVDLLCAALLMPLGIVcgsPFFAGIV------FSVLECR 121
Cdd:cd15959    2 LAGALLSLAILVI-VGGNLLVIVAIAKTPRLQTMTNVF---VTSLACADLVMGLLVV---PPGATILltghwpLGTTVCE 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 122 LYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFG-WPSYGSRSSIAATHC 200
Cdd:cd15959   75 LWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNqWWRDGADEEAQRCYD 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAAR----ERGPIPSWTMATAHPKRRSDsvnsqttiitt 276
Cdd:cd15959  155 NPRCCDFVTNMPYAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVRlirkDKVRFPPEESPPAESRPACG----------- 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 277 stsvrrnqvpRRKRRTLV--GGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHsTSEEAEGPVTWLAYSTFAVNPFFY 354
Cdd:cd15959  224 ----------RRPSRLLAikEHKALKTLGIIMGTFTLCWLPFFVANIIKVFCRSL-VPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
51-359 3.11e-18

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 83.85  E-value: 3.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLLCAALLMPLGIV---CGSPFFAGIVFsvleCRLYIF 125
Cdd:cd15328    4 LTLLAMLVVATFLWNLLVLVTILRVRtfHRVPHNLVASMAVSDVLVAALVMPLSLVhelSGRRWQLGRSL----CQVWIS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATV-FGWpsyGSRSSIAATHCSLHW 204
Cdd:cd15328   80 FDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLlFGW---GETYSEDSEECQVSQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSghrrvFAILFCTLCFCVPAAIIIAVYGNVYKVAHtaaRERgpipswtmatahpkrrsdsvnsqttiittstsvrrnq 284
Cdd:cd15328  157 EPS-----YTVFSTFGAFYLPLCVVLFVYWKIYKAAQ---KEK------------------------------------- 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966710671 285 vprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLgFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNR 359
Cdd:cd15328  192 ------------RAALMVGILIGVFVLCWIPFFLTELISPL-CSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNK 253
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
59-363 6.11e-18

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 83.46  E-value: 6.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSG---VLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLGIVCGspffAGIVFSVLECrlyIFLNAFLI-- 131
Cdd:cd14968    9 LIAVLSVLGnvlVIWAVKLNRALRTvtNYFIVSLAVADILVGALAIPLAILIS----LGLPTNFHGC---LFMACLVLvl 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 132 -SASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWpsYGSRSSIAATHCSLHWSH---- 206
Cdd:cd14968   82 tQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGW--NNGAPLESGCGEGGIQCLfeev 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 -SGHRRVFAILFctLCFCVPAAIIIAVYGNVYKVAHTAARErgpIPSWTMAtahpkrrsdsvnsqttiittstsvRRNQV 285
Cdd:cd14968  160 iPMDYMVYFNFF--ACVLVPLLIMLVIYLRIFRVIRKQLRQ---IESLLRS------------------------RRSRS 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 286 PRRKRRtlvggKAALTLAIIVGQFLLCWLPyfafhLHLSLGFSHsTSEEAEGPVTW------LAYSTFAVNPFFYGLLNR 359
Cdd:cd14968  211 TLQKEV-----KAAKSLAIILFLFALCWLP-----LHIINCITL-FCPECKVPKILtyiailLSHANSAVNPIVYAYRIR 279

                 ....
gi 966710671 360 QIRE 363
Cdd:cd14968  280 KFRQ 283
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
52-363 9.49e-18

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 83.11  E-value: 9.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVtlnAIALLANSGVLTVVVKVPHLRKFS---LVcHLCIVDLLCAALLMPLGIVCGS----PFfaGIVFsvleCRLYI 124
Cdd:cd15390    8 VVMV---LVAIGGNLIVIWIVLAHKRMRTVTnyfLV-NLAVADLLISAFNTVFNFTYLLyndwPF--GLFY----CKFSN 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGL-----ATVFGWPSYGSRSSiaaTH 199
Cdd:cd15390   78 FVAITTVAASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALpqllySTTETYYYYTGSER---TV 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 200 CSLHW---SHSGHRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPipswtmatahpkrrsdsvnsqttiitT 276
Cdd:cd15390  153 CFIAWpdgPNSLQDFVYNIVLFVVTYFLPLIIMAVAY---TRVGVELWGSKTI--------------------------G 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 277 STSVRRNQVPRRKRrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEG---PVTWLAYSTFAVNPFF 353
Cdd:cd15390  204 ENTPRQLESVRAKR------KVVKMMIVVVVIFAICWLPYHLYFILTYLYPDINSWKYIQQiylAIYWLAMSNSMYNPII 277
                        330
                 ....*....|
gi 966710671 354 YGLLNRQIRE 363
Cdd:cd15390  278 YCWMNKRFRY 287
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
51-363 1.07e-17

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 82.25  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVCGSPFFAGI---VFSVLECRLYIFLN 127
Cdd:cd15325    1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILgywAFGRVFCNIWAAVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaaTHCSLHwSHS 207
Cdd:cd15325   81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWKEPAPEDE---TICQIT-EEP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 208 GHrrvfaILFCTL-CFCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvp 286
Cdd:cd15325  157 GY-----ALFSALgSFYLPLAIILVMYCRVYVVALKFSREK--------------------------------------- 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 287 rrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15325  193 ----------KAAKTLGIVVGCFVLCWLPFFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKK 259
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
59-354 1.85e-17

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 82.26  E-value: 1.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVcgsPFFAGIV------FSVLECRLYIFLNAFLIS 132
Cdd:cd15958    9 LIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVV---PFGATLVvrgrwlYGSFFCELWTSVDVLCVT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLG-LATVFGWpsyGSRSSIAATHCslhWSHSG--- 208
Cdd:cd15958   86 ASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfLPIMMHW---WRDEDDQALKC---YEDPGccd 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 --HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAAR-----ERGPIPSWTMATAHPKRRSDSVnsqttiittstSVR 281
Cdd:cd15958  160 fvTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIKkidkcEGRFHNTLTGLGRKCKRRPSRI-----------LAL 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 282 RNQvprrkrrtlvggKAALTLAIIVGQFLLCWLPYF------AFHLHLslgfshsTSEEAEGPVTWLAYSTFAVNPFFY 354
Cdd:cd15958  229 REQ------------KALKTLGIIMGVFTLCWLPFFlvnvvnVFNREL-------VPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
82-362 3.95e-17

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 80.85  E-value: 3.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  82 SLVCHLCIVDLLCAALLMPLGI----VCGSPFFAGIVfsvleCRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEA 157
Cdd:cd15053   37 YFIVSLAVADLLVAILVMPFAVyvevNGGKWYLGPIL-----CDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYAR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 158 KMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaaTHCSLhwshsgHRRVFAILFCTLCFCVPAAIIIAVYGNVY 237
Cdd:cd15053  112 QKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDP---EECRF------YNPDFIIYSSISSFYIPCIVMLLLYYRIF 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 238 KVAHtaaRERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYF 317
Cdd:cd15053  183 RALR---REK-------------------------------------------------KATKTLAIVLGVFLFCWLPFF 210
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 966710671 318 AFHLHLSLGFSHSTSEEAEGP-----VTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15053  211 TLNILNAICPKLQNQSCHVGPalfslTTWLGYVNSFLNPIIYTIFNIEFR 260
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
52-363 6.13e-17

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 80.59  E-value: 6.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK---FSLVcHLCIVDLLCAALLMPLGIVCGSP--FFAGIVFSVLECrlyiFL 126
Cdd:cd15075    5 IIMAVFSIASVVLNATVIIVTLRHKQLRQplnYALV-NLAVADLGTTVFGGLLSVVTNAVgyFNLGRVGCVLEG----FA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRyEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSsiAATHCSLHWSH 206
Cdd:cd15075   80 VAFFGIAALCTVAVIAVDRLFVVCKPLG-TLTFQTRHALAGIASSWLWSLIWNTPPLFGWGSYQLEG--VMTSCAPDWYS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SGHRRVFAIL-FCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswTMATAHPKRRSDSVNSqttiittstsvrrnqv 285
Cdd:cd15075  157 RDPVNVSYILcYFSFCFAIPFAIILVSYGYLLWTLRQVAKL-------GVAEGGSTAKAEVQVA---------------- 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 286 prrkRRTLVggkaaltlaiIVGQFLLCWLPYFAFHLHLSlgfshSTSEEAEGPV-----TWLAYSTFAVNPFFYGLLNRQ 360
Cdd:cd15075  214 ----RMVVV----------MVMAFLLCWLPYAAFALTVV-----SKPDVYINPLiatvpMYLAKSSTVYNPIIYIFMNKQ 274

                 ...
gi 966710671 361 IRE 363
Cdd:cd15075  275 FRD 277
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
87-362 6.99e-17

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 80.05  E-value: 6.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIVcgSPFFAGI-VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSA 165
Cdd:cd15052   42 LAIADLLVGLLVMPLSIL--TELFGGVwPLPLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVF 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 166 AVMGFVWVASTLLGLA-TVFGwpSYGSRSSIAATHCSLhwshsgHRRVFAILFCTLCFCVPAAIIIAVYGnvyKVAHTAA 244
Cdd:cd15052  120 LKIAIVWLISIGISSPiPVLG--IIDTTNVLNNGTCVL------FNPNFVIYGSIVAFFIPLLIMVVTYA---LTIRLLS 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 245 RERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAfhLHLS 324
Cdd:cd15052  189 NEQ-------------------------------------------------KASKVLGIVFAVFVICWCPFFI--TNIL 217
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 966710671 325 LGFSHSTSEEAEGPV----TWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15052  218 TGLCEECNCRISPWLlsvfVWLGYVSSTINPIIYTIFNKTFR 259
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
87-371 8.33e-17

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 80.00  E-value: 8.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAA 166
Cdd:cd15307   42 LAITDLMVAVLVMPLGIL--TLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 167 VMGFVWVASTLLGLATVFGWpSYGSRSSIAATHCSLHWShsghrrVFAILFCTLCFCVPAAIIIAVYGnvyKVAHTAARE 246
Cdd:cd15307  120 KIVFVWLLSIAMSLPLSLMY-SKDHASVLVNGTCQIPDP------VYKLVGSIVCFYIPLGVMLLTYC---LTVRLLARQ 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 247 RGpipswtmatahpkrrsdsvnsqttiittstsvrrnqvpRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLG 326
Cdd:cd15307  190 RS--------------------------------------RHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVC 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 966710671 327 FSHSTSEEAE--GPVTWLAYSTFAVNPFFYGLLNRQIREELCKMLFC 371
Cdd:cd15307  232 AECEERISHWvfDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLC 278
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
52-354 1.33e-16

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 79.91  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMPLGIVcgsPFFAGIV------FSVLECRLYIF 125
Cdd:cd15957    5 IVMSLIVLAIVFGNVLVITAIAKFERLQT---VTNYFITSLACADLVMGLAVV---PFGAAHIllktwtFGNFWCEFWTS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLG-LATVFGWPSYGSRSSI---AATHCS 201
Cdd:cd15957   79 IDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSfLPIQMHWYRATHQEAIncyAEETCC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 202 LHWSHSGhrrvFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARergpipswtmatahpKRRSDSVNSQTTIITTSTSVR 281
Cdd:cd15957  159 DFFTNQA----YAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ---------------KIDKSEGRFHNQNIDQNGSGG 219
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966710671 282 RNQVPRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFY 354
Cdd:cd15957  220 GGGNRRRSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNI-VHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
51-358 2.17e-16

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 79.44  E-value: 2.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRLYIFL 126
Cdd:cd15205    4 VITYVLIFVLALFGNSLVIYVVTRKRAMRTATniFICSLALSDLLITFFCIPFTLLqnISSNWLGGAFM----CKMVPFV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGW-------PSYGSRSSIaath 199
Cdd:cd15205   80 QSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQqlevkydFLYEKRHVC---- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 200 CSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPIPSWTMATAHPKRRSDSVnsqttiittsts 279
Cdd:cd15205  156 CLERWYSPTQQKIYTTFILVILFLLPLTTMLFLY---SRIGYELWIKKRVGDASVLQTIHGIEMSKIS------------ 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 280 vrrnqvpRRKRRtlvggkAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAE-----GPVTWLAYSTFAVNPFFY 354
Cdd:cd15205  221 -------RKKKR------AVKMMVTVVLLFAVCWAPFHVVHMMIEYSNLENKYDGVTiklifAIVQLIGFSNSFNNPIVY 287

                 ....
gi 966710671 355 GLLN 358
Cdd:cd15205  288 AFMN 291
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
52-362 2.33e-16

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 78.62  E-value: 2.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVCgspFFAGI-VFSVLECRLYIFLNA 128
Cdd:cd15050    5 IALSTISLITVILNLLVLYAVRTERKLHTVGnlYIVSLSVADLIVGAVVMPLNIVY---LLESKwILGRPVCLFWLSMDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVAStLLGLATVFGWPSY--GSRSSIAATHCSLHWSH 206
Cdd:cd15050   82 VASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLS-FLWVIPILGWHHFarGGERVVLEDKCETDFHD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SghrRVFAILFCTLCFCVPAAIIIAVYGNVYkvaHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvp 286
Cdd:cd15050  161 V---TWFKVLTAILNFYIPSLLMLWFYAKIF---KAVNRER--------------------------------------- 195
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 287 rrkrrtlvggKAALTLAIIVGQFLLCWLPYFAfhLHLSLGFSHSTSEEAEGPVT-WLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15050  196 ----------KAAKQLGFIMAAFILCWIPYFI--LFMVIAFCKNCCNENLHMFTiWLGYINSTLNPFIYPLCNENFK 260
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
50-362 2.87e-16

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 78.16  E-value: 2.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  50 GLVVMVTLnaialLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLN 127
Cdd:cd15331    8 GLLILATI-----IGNVFVIAAILLERSLQGVSnyLILSLAVADLMVAVLVMPLSAV--YEVSQHWFLGPEVCDMWISMD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYfYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATH-CSLHWSH 206
Cdd:cd15331   81 VLCCTASILHLVAIALDRY-WAVTNIDYIRRRTAKRILIMIAVVWFVSLIISIAPLFGWKDEDDLDRVLKTGvCLISQDY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SghrrvFAIlFCTLC-FCVPAAIIIAVYGNVYKVAHtaaRERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqv 285
Cdd:cd15331  160 G-----YTI-FSTVGaFYVPLLLMIIIYWKIYQAAK---RER-------------------------------------- 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 286 prrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15331  193 -----------KAARTLAIITGAFVVCWLPFFLVALVMPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDFR 258
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
60-365 3.66e-16

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 78.48  E-value: 3.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMplgIVCGSPFFAGI------VFSVLECRLYIFLNAFLISA 133
Cdd:cd15095   13 VGLAGNSLVIYVVSRHREMRT---VTNYYIVNLAVTDLAF---LVCCVPFTAALyatpswVFGDFMCKFVNYMMQVTVQA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLAT-----VFGWPSYGSRssiaaTHCSLHWSHSG 208
Cdd:cd15095   87 TCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVaiyyrLEEGYWYGPQ-----TYCREVWPSKA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVYG-NVYKVahtaarergpipsWTMATAHPKRRSdsvnsqttiittstsVRRNQVPR 287
Cdd:cd15095  162 FQKAYMIYTVLLTYVIPLAIIAVCYGlILRRL-------------WRRSVDGNNQSE---------------QLSERALR 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 288 RKRRTlvggkaALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW---LAYSTFAVNPFFYGLLNRQIREE 364
Cdd:cd15095  214 QKRKV------TRMVIVVVVLFAICWLPNHVLNLWQRFDPNFPETYATYALKIAalcLSYANSAVNPFVYAFMGENFRKY 287

                 .
gi 966710671 365 L 365
Cdd:cd15095  288 F 288
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
59-362 8.53e-16

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 77.12  E-value: 8.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMplgIVCGSPFFAGI------VFSVLECRLYIFLNAFLIS 132
Cdd:cd14971   12 LLGLVGNSLVILVVARNKPMRS---TTNLFILNLAVADLTF---LLFCVPFTATIyplpgwVFGDFMCKFVHYFQQVSMH 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpSYGSRSSIAATH--CSLHWSHSGHR 210
Cdd:cd14971   86 ASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLA---LHRLRNYTPGNRtvCSEAWPSRAHR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 211 RVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpkrrsdsvnsqttiittsTSVRRNQVPRRKR 290
Cdd:cd14971  163 RAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVA---------------------------------VRPVLSEGSRRAK 209
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 291 RtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVT--WLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd14971  210 R-----KVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLTYATYALRIWahCLAYSNSAVNPVLYAFLSEHFR 278
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
83-363 1.50e-15

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 76.16  E-value: 1.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  83 LVCHLCIVDLLCAALLMPLGI---VCGSPFfagiVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKM 159
Cdd:cd15310   38 LVVSLAVADLLVATLVMPWVVyleVTGGVW----NFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 160 TPWLS---AAVMGFVWVASTLLGLATVFGWPSYGSrssiaATHCSLhwshsgHRRVFAILFCTLCFCVPAAIIIAVYGNV 236
Cdd:cd15310  114 GQSSCrrvSLMITAVWVLAFAVSCPLLFGFNTTGD-----PTVCSI------SNPDFVIYSSVVSFYLPFGVTLLVYVRI 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 237 YKVahtAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPY 316
Cdd:cd15310  183 YVV---LLREK-------------------------------------------------KATQMLAIVLGAFIVCWLPF 210
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 966710671 317 FAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15310  211 FLTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
52-363 2.25e-15

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 76.24  E-value: 2.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMPLGIVCGSpFFAGIV-----FSVLECRLYIFL 126
Cdd:cd15392    5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRT---VTNYFIVNLALSDILMAVFCVPFS-FIALLIlqywpFGEFMCPVVNYL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWV--ASTLLGLATVFGWPSYgSRSSIAATHCSLHW 204
Cdd:cd15392   81 QAVSVFVSAFTLVAISIDRYVAIMWPLR--PRMTKRQALLLIAVIWIfaLATALPIAITSRLFED-SNASCGQYICTESW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGHRRVFAILFCTLCFCVPAAIIIAVYGNV-YKVahtaarergpipsWTMATahPKRRSDSvnsqttiittstsvrRN 283
Cdd:cd15392  158 PSDTNRYIYSLVLMILQYFVPLAVLVFTYTRIgIVV-------------WAKRT--PGEAENN---------------RD 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 QVPRRKRRTLVggKAALTLAIIvgqFLLCWLPYFAFHLhlsLGFSHSTSEEAEG------PVTWLAYSTFAVNPFFYGLL 357
Cdd:cd15392  208 QRMAESKRKLV--KMMITVVAI---FALCWLPLNILNL---VGDHDESIYSWPYipylwlAAHWLAMSHCCYNPFIYCWM 279

                 ....*.
gi 966710671 358 NRQIRE 363
Cdd:cd15392  280 NAKFRN 285
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
51-365 3.21e-15

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 75.81  E-value: 3.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVK------VPHLRKFSLVCHLCIVDLLCAALLMPLGIVCGS--PFFAGIVFsvleCRL 122
Cdd:cd15382    1 LVSIIVYSVLFLIAAVGNLTVLLIllrnrrRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAAtvAWLAGDFL----CRL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 123 YIFLNAFLISASIFTVTVISIERYFYIVHPMR-YEAKMTpwlSAAVMGFVWVASTLLGLATVFGWpsygsrssiaatHCS 201
Cdd:cd15382   77 MLFFRAFGLYLSSFVLVCISLDRYFAILKPLRlSDARRR---GRIMLAVAWVISFLCSIPQSFIF------------HVE 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 202 LHWSHSG------------HRRVFAILFCTLC--FCVPAAIIIAVYGNVYkvahtaarergpipsWTMAtahpkRRSDSV 267
Cdd:cd15382  142 SHPCVTWfsqcvtfnffpsHDHELAYNIFNMItmYALPLIIIVFCYSLIL---------------CEIS-----RKSKEK 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 268 NSQTTIITTSTSVRRNQV---PRRKRRTLvggkaALTLaIIVGQFLLCWLPYFAfhLHLSLGFSHSTSEEAEGPVTWLAY 344
Cdd:cd15382  202 KEDVSEKSSSVRLRRSSVgllERARSRTL-----KMTI-VIVLVFIICWTPYFI--MSLWYWFDRESASKVDPRIQKGLF 273
                        330       340
                 ....*....|....*....|....*.
gi 966710671 345 sTFAV-----NPFFYGLLNRQIREEL 365
Cdd:cd15382  274 -LFAVsnscmNPIVYGYFSIDLRREL 298
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
60-364 4.76e-15

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 75.50  E-value: 4.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMPlgIVCgspFFAGIVFSVLE--------CRLYIFLNAFLI 131
Cdd:cd15208   13 VGLVGNVLVCFAVWRNHHMRT---VTNYFIVNLSLADFLVI--IIC---LPATLLVDVTEtwffgqvlCKIIPYLQTVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 132 SASIFTVTVISIERYFYIVHPMRYeaKMTPWLSAAVMGFVWVASTL--------LGLATVFGWPSYgsrsSIAATHCSLH 203
Cdd:cd15208   85 SVSVLTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLimipqaivMECSRVVPLANK----TILLTVCDER 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WSHSGHRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPIPSWTMATAHPKRRSDSVNSQttiittstsvrRN 283
Cdd:cd15208  159 WSDSIYQKVYHICFFLVTYLLPLCLMILAY---FQIFRKLWCRQIPGTSSVVQRKWNKPRKSAVAAE-----------EK 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 QVPRRKrrtlvggKAALTLAIIVGQFLLCWLPYFAFH-LHLSLGFSHSTSEEAEGPVT---WLAYSTFAVNPFFYGLLNR 359
Cdd:cd15208  225 QLRSRR-------KTAKMLIVVVIMFAICYLPVHLLNiLRYVFGLFTVDRETIYAWFLfshWLVYANSAINPIIYNFMSG 297

                 ....*
gi 966710671 360 QIREE 364
Cdd:cd15208  298 KFREE 302
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
50-363 5.09e-15

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 74.83  E-value: 5.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  50 GLVVMVTLNAIA-LLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGI---VCGSPFFAGIVfsvleCRLY 123
Cdd:cd15333    6 SLAVLLALITLAtTLSNAFVIATIYLTRKLHTPAnyLIASLAVTDLLVSILVMPISIvytVTGTWTLGQVV-----CDIW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgWPSygSRSSIAATHCSLH 203
Cdd:cd15333   81 LSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFF-WRQ--AKAEEEVSECVVN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WSHsghrrVFAILFCTL-CFCVPAAIIIAVYGNVYKVAHtaARERgpipswtmatahpkrrsdsvnsqttiittstsvrr 282
Cdd:cd15333  158 TDH-----ILYTVYSTVgAFYIPTLLLIALYGRIYVEAR--ARER----------------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 nqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSL----GFSHSTSEEAegpVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd15333  196 --------------KATKTLGIILGAFIVCWLPFFIISLVLPIckdaCWFHLAIFDF---FTWLGYLNSLINPIIYTMSN 258

                 ....*
gi 966710671 359 RQIRE 363
Cdd:cd15333  259 EDFKQ 263
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
51-240 1.38e-14

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 73.34  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVCGSPFFAGIVFSVleCRLYIFLNA 128
Cdd:cd15215    3 SVLIVIFLCASLFGNIVLLLVFQRKPQLLQVAnrFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHL--CTALVVLMH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGW--PSYGSRSSIaathCSLHWSH 206
Cdd:cd15215   81 LFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWgqAAFDERNAL----CSVIWGS 156
                        170       180       190
                 ....*....|....*....|....*....|....
gi 966710671 207 SghrRVFAILFCTLCFCVPAAIIIAVYGNVYKVA 240
Cdd:cd15215  157 S---YSYTILSVVSSFVLPVIIMLACYSMVFRAA 187
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
53-365 1.64e-14

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 73.60  E-value: 1.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15336    6 VILIIGITGMLGNALVIYAFCRSKKLRTPAnyFIINLAVSDFLMSLTQSPIFFV--NSLHKRWIFGEKGCELYAFCGALF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIaaTHCSLHW-SHSGH 209
Cdd:cd15336   84 GITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGLL--TSCTWDYmTFTPS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSwtmatahpkrrsdsvnsqttiittstSVRRNQVPRRK 289
Cdd:cd15336  162 VRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRSTGREVQKLGS--------------------------QDRKEKAKQYQ 215
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 290 RRTLVGGKAALTLAIIVgQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15336  216 RMKNEWKMAKIAFVVIL-LFVLSWSPYACVALIAWAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYREAI 290
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
81-363 1.94e-14

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 72.74  E-value: 1.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  81 FSLVChlciVDLLCAALLMPL---GIVCGSPFFAGIVfsvleCRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEA 157
Cdd:cd15049   40 LSLAC----ADLIIGLVSMNLytvYLVMGYWPLGPLL-----CDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 158 KMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSghrRVFAILFCTLCFCVPAAIIIAVYGNVY 237
Cdd:cd15049  111 KRTPKRAILMIALAWVISFVLWAPAILGWQYFVGERTVPDGQCYIQFLDD---PAITFGTAIAAFYLPVLVMTILYWRIY 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 238 KvahTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYF 317
Cdd:cd15049  188 R---ETARER-------------------------------------------------KAARTLSAILLAFIITWTPYN 215
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 966710671 318 AfhLHLSLGFSHSTSEEAEGPVT-WLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15049  216 I--LVLVSTFCAKCIPDTLWSFGyWLCYINSTINPFCYALCNKTFRK 260
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
62-364 2.18e-14

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 73.54  E-value: 2.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  62 LLANSGVLTVVVKVPHLRKFSlvcHLCIVDLLCAALLMplgIVCGSPF--FAGI-----VFSVLECRLYIFLNAFLISAS 134
Cdd:cd14979   15 IVGNLLTCIVIARHKSLRTTT---NYYLFSLAVSDLLI---LLVGLPVelYNFWwqypwAFGDGGCKLYYFLFEACTYAT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 135 IFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFG----WPSYGSRSSIA-ATHCSLHWSHSGH 209
Cdd:cd14979   89 VLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLmgiqYLNGPLPGPVPdSAVCTLVVDRSTF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCtLCFCVPAAIIIAVYGnvyKVAHTAARERgpipswtmatahpkrrsdsvNSQTTIITTSTSVRRNQVPRRK 289
Cdd:cd14979  169 KYVFQVSTF-IFFVLPMFVISILYF---RIGVKLRSMR--------------------NIKKGTRAQGTRNVELSLSQQA 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 290 RRTLVggkaaLTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSE----EAEGPVT-WLAYSTFAVNPFFYGLLNRQIREE 364
Cdd:cd14979  225 RRQVV-----KMLGAVVIAFFVCWLPFHAQRLMFSYASKEDTFLfdfyQYLYPISgILFYLSSAINPILYNLMSSRFRVA 299
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
59-365 2.18e-14

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 72.91  E-value: 2.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIF 136
Cdd:cd15054   12 LLTVAGNSLLILLIFTQRSLRNTSnyFLVSLFMSDLMVGLVVMPPAML--NALYGRWVLARDFCPIWYAFDVMCCSASIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 137 TVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTL-------LGLATVFGWPSYGSRSSIAAT-HCSLHWSHSg 208
Cdd:cd15054   90 NLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALasflpieLGWHELGHERTLPNLTSGTVEgQCRLLVSLP- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 hrrvFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprr 288
Cdd:cd15054  169 ----YALVASCLTFFLPSGAICFTYCRILLAARKAL-------------------------------------------- 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 289 krrtlvggKAALTLAIIVGQFLLCWLPYFAfhLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15054  201 --------KASLTLGILLGMFFVTWLPFFV--ANVVQAVCDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
54-238 2.59e-14

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 72.85  E-value: 2.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  54 MVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLI 131
Cdd:cd15073    7 LIVAGIISTISNGIVLVTFVKFRELRTPTnaLIINLAVTDLGVSIIGYPFSAA--SDLHGSWKFGYAGCQWYAFLNIFFG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 132 SASIFTVTVISIERYFYIVHPMRYEaKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAthCSLHWSHSGHRR 211
Cdd:cd15073   85 MASIGLLTVVAVDRYLTICRPDLGR-KMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGAT--CTINWRKNDSSF 161
                        170       180
                 ....*....|....*....|....*...
gi 966710671 212 V-FAILFCTLCFCVPAAIIIAVYGNVYK 238
Cdd:cd15073  162 VsYTMSVIVVNFIVPLAVMFYCYYNVSR 189
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
48-363 6.60e-14

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 71.54  E-value: 6.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  48 MSGLVVMVTL--NAIALLANSgVLTVVVKVPHLRKFSLVChlciVDLLCAALLMPLG---IVCGSpffagIVFSVLECRL 122
Cdd:cd17790    6 TTGILSLVTVtgNLLVLISFK-VNSELKTVNNYFLLSLAC----ADLIIGAFSMNLYttyILMGH-----WALGTVACDL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 123 YIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSL 202
Cdd:cd17790   76 WLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTVLAGQCYI 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHSGhrrvfAILFCT--LCFCVPAAIIIAVYGNVYkvahtaarergpipswtmatahpkrrsdsvnsqttiittstsv 280
Cdd:cd17790  156 QFLSQP-----IITFGTaiAAFYLPVTIMIILYWRIY------------------------------------------- 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 281 rrnqvprrkRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQ 360
Cdd:cd17790  188 ---------RETIKEKKAARTLSAILLAFILTWTPYNIMVL-VSTFCKDCVPKTLWELGYWLCYVNSTVNPMCYALCNKS 257

                 ...
gi 966710671 361 IRE 363
Cdd:cd17790  258 FRD 260
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
60-363 8.01e-14

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 71.27  E-value: 8.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFSLV--CHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15206   13 LAVVGNILVIVTLVQNKRMRTVTNVflLNLAVSDLLLAVFCMPFTLV--GQLLRNFIFGEVMCKLIPYFQAVSVSVSTFT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLgLATVFGWPSYGSRSSIAATHCSLHWSHSGHRRVFAILF 217
Cdd:cd15206   91 LVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLI-MSPILVFSNLIPMSRPGGHKCREVWPNEIAEQAWYVFL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 218 CTLCFCVPAAIIIAVYGNVykvahtaarergpipSWTMATAhpkrrsdsvnsqttiittstsvrrnqvprrKRRTLvggk 297
Cdd:cd15206  170 DLMLLVIPGLVMSVAYGLI---------------SWTLLEA------------------------------KKRVI---- 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 298 aaLTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW---LAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15206  201 --RMLFVIVVEFFICWTPLYVINTWKAFDPPSAARYVSSTTISLiqlLAYISSCVNPITYCFMNKRFRQ 267
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
60-365 8.18e-14

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 71.39  E-value: 8.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRK-FSL-VCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15391   13 LSVGGNYSVIVVFYDGRRSRTdLNYyLINLAVSDLIMALFCMPFTFT--QIMLGHWVFPAPMCPIVLYVQLVSVTASVLT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLL-------GLATVFGWPSYGSRSsiaathCSLHWSHSGH- 209
Cdd:cd15391   91 NTAIGIDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSLssvqlfaGRTQRYGQYSEGRVL------CGESWPGPDTs 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCTLCFCVPAAIIIAVYGNVykvahtaarergPIPSWtmatahpkRRSDSVNSqttiittsTSVRRNQVPRRK 289
Cdd:cd15391  163 RSAYTVFVMLLTYIIPLLILTSTYGYV------------GFRLW--------NRTAPGNA--------DKGRDDMQIKSK 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 290 RRTLVggkaalTLAIIVGQFLLCWLPYFAFHL-----HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREE 364
Cdd:cd15391  215 RKVIK------MLVFVVLMFGICWLPLHLFNLvqdfsTVFRNMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRSI 288

                 .
gi 966710671 365 L 365
Cdd:cd15391  289 L 289
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-363 9.57e-14

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 71.34  E-value: 9.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPhlrKFSLVCHLCIVDLLCAALLMPLGIvcgsPFFAGIV------FSVLECRLYIFLNAFLIS 132
Cdd:cd15093   12 LVGLCGNSLVIYVVLRYA---KMKTVTNIYILNLAIADELFMLGL----PFLAASNalrhwpFGSVLCRLVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLAT-VFGWPSYGSRSSIAathCSLHWSHSGH-- 209
Cdd:cd15093   85 TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVvVFAGTRENQDGSSA---CNMQWPEPAAaw 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCTLCFCVPAAIIIAVYG-NVYKVAHTAARergpiPSWTmatahpkRRsdsvnsqttiittstsvrrnqvpRR 288
Cdd:cd15093  162 SAGFIIYTFVLGFLLPLLIICLCYLlIVIKVKSAGLR-----AGWQ-------QR-----------------------KR 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 289 KRRtlvggKAALTLAIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGP---VTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15093  207 SER-----KVTRMVVMVVVVFVICWLPFYVLQL-VNVFVQLPETPALVGVyhfVVILSYANSCANPILYGFLSDNFKK 278
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
89-365 1.01e-13

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 70.93  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  89 IVDLLCAALLMPLGI--VCGSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRyEAKMTPWLSAA 166
Cdd:cd14999   38 ILNLALADLLYLLTIpfYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 167 VMGFVWVASTLLGLATVF-------GWPSYGSRSSIAAThcslhWSHSGHRRVFAILFCTlCFCVPAAIIIAVYGnvyKV 239
Cdd:cd14999  117 LAGVIWLLSLLLTLPMAImirlvtvEDKSGGSKRICLPT-----WSEESYKVYLTLLFST-SIVIPGLVIGYLYI---RL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 240 AHTAarergpipsWTMATAhpkrrsdsvnsqttiittstsvrrnqVPRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAF 319
Cdd:cd14999  188 ARKY---------WLSQAA--------------------------ASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIW 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 966710671 320 HL----HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd14999  233 QLlylySPSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
120-364 1.37e-13

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 70.90  E-value: 1.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSY---GSRSSIA 196
Cdd:cd15393   73 CPFCPFVQVLSVNVSVFTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALPVALALRVEeltDKTNNGV 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 197 ATHCSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVykvahtAARERGpipswtmaTAHPKRRSDSvnsqttiitt 276
Cdd:cd15393  151 KPFCLPVGPSDDWWKIYNLYLVCVQYFVPLVIICYAYTRI------AVKIWG--------TKAPGNAQDV---------- 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 277 stsvrRNQVPRRKRRTLVGgkaalTLAIIVGQFLLCWLPYFAF--------------HLHLSLGFSHstseeaegpvtWL 342
Cdd:cd15393  207 -----RDDEILKNKKKVIK-----MLIIVVALFALCWLPLQTYnllneikpeinkykYINIIWFCSH-----------WL 265
                        250       260
                 ....*....|....*....|..
gi 966710671 343 AYSTFAVNPFFYGLLNRQIREE 364
Cdd:cd15393  266 AMSNSCYNPFIYGLYNEKFKRE 287
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
51-364 1.42e-13

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 70.89  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKF-----SLVCHLCIVDLLCAALLMPLGIVCGSP--FFAGIVFsvleCRLY 123
Cdd:cd15195    1 LVRVLVTWVLFVISAAGNLTVLIQLFRRRRAkshiqILIMHLALADLMVTFFNMPMDAVWNYTveWLAGDLM----CRVM 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPM---RYEAKMTPWLSAAvmgfvWVASTLLGL--ATVFGWPSYGSRsSIAAT 198
Cdd:cd15195   77 MFLKQFGMYLSSFMLVVIALDRVFAILSPLsanQARKRVKIMLTVA-----WVLSALCSIpqSFIFSVLRKMPE-QPGFH 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 HCSLHWSHSGHRRVFAILFCTLC--FCVPAAIIIAVYGN-VYKVAHTAARERgpipswtmATAHPKRRSdsvnsqttiit 275
Cdd:cd15195  151 QCVDFGSAPTKKQERLYYFFTMIlsFVIPLIITVTCYLLiLFEISKMAKRAR--------DTPISNRRR----------- 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 276 tstsVRRNQVPRRKRRTLVggkaaLTlAIIVGQFLLCWLPYFAfhlhlsLGFSHSTSEEAEGPVT--------WLAYSTF 347
Cdd:cd15195  212 ----SRTNSLERARMRTLR-----MT-ALIVLTFIVCWGPYYV------LGLWYWFDKESIKNLPpalshimfLLGYLNP 275
                        330
                 ....*....|....*..
gi 966710671 348 AVNPFFYGLLNRQIREE 364
Cdd:cd15195  276 CLHPIIYGVFMKEIRNW 292
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
82-362 1.64e-13

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 70.25  E-value: 1.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  82 SLVCHLCIVDLLCAALLMPLGIVcgSPFFAGI-VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMT 160
Cdd:cd15308   37 YFIVSLAVADLLLALLVLPLYVY--SEFQGGVwTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQG 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 161 PWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaaTHCSLHWSHSghrrvfaILFCTLC-FCVPAAIIIAVYgnvYKV 239
Cdd:cd15308  115 SVRQLLLISATWILSFAVASPVIFGLNNVPNRDP---AVCKLEDNNY-------VVYSSVCsFFIPCPVMLVLY---CAM 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 240 AHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAF 319
Cdd:cd15308  182 FRGLGRER-------------------------------------------------KAMRVLPVVVGAFLFCWTPFFVV 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966710671 320 HLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15308  213 HITRALCESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
51-362 2.19e-13

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 70.14  E-value: 2.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS----LVCHLCIVDLLCaallmplgIVCGSPFFAGI------VFSVLEC 120
Cdd:cd15098    4 PVVFGLIFCLGVLGNSLVITVLARVKPGKRRSttnvFILNLSIADLFF--------LLFCVPFQATIyslpewVFGAFMC 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 121 RLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL------ATVFGWPSYGSrss 194
Cdd:cd15098   76 KFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASpvavhqDLVHHWTASNQ--- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 195 iaaTHCSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtmatahpkrrsdsvnsqttii 274
Cdd:cd15098  153 ---TFCWENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKN---------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 275 ttstsvrrnqvpRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVT--WLAYSTFAVNPF 352
Cdd:cd15098  202 ------------MSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDFPLTQASFVLRITahCLAYANSCVNPI 269
                        330
                 ....*....|
gi 966710671 353 FYGLLNRQIR 362
Cdd:cd15098  270 IYAFLSENFR 279
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
52-363 2.52e-13

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 69.70  E-value: 2.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15213    5 ILMILMIFVGFLGNSIVCLIVYQKPAMRSAInlLLANLAFSDIMLSLVCMPFAAV--TIITGRWIFGDIFCRISAMLYWF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVhpmRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaATHCSLHWSHSGH 209
Cdd:cd15213   83 FVLEGVAILLIISVDRYLIIV---QRQDKLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPR--APQCVLGYTESPA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCTLCFCVPAAIIIAVYGNVYkvahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrNQVPRRK 289
Cdd:cd15213  158 DRIYVVLLLVAVFFIPFLIMLYSYFCIL---------------------------------------------NTVRSFK 192
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 290 RRtlvggkAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15213  193 TR------AFTTILILFIGFSVCWLPYTVYSLLSVFSRYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFRE 260
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
83-363 3.16e-13

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 69.29  E-value: 3.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  83 LVCHLCIVDLLCAALLMPLGIVCgsPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPW 162
Cdd:cd15309   38 LIVSLAVADLLVATLVMPWVVYL--EVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 163 LSAAVM-GFVWVASTLLGLATVFGWPSYGSRSSIAAThcslhwshsghrRVFAILFCTLCFCVPAAIIIAVYGNVYKVAH 241
Cdd:cd15309  116 RRVTVMiSVVWVLSFAISCPLLFGLNNTDQNECIIAN------------PAFVVYSSIVSFYVPFIVTLLVYVQIYIVLQ 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 242 TAArergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHL 321
Cdd:cd15309  184 KEK----------------------------------------------------KATQMLAIVLGVFIICWLPFFITHI 211
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 966710671 322 hLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15309  212 -LNMHCDCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRK 252
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
61-356 3.40e-13

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 69.50  E-value: 3.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  61 ALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALL-----MPLGIV--CGSPFFAGIVFsvleCRLYIFLNAFLISA 133
Cdd:cd15316   11 AVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLvgvtvMPFSTVrsVESCWYFGESF----CTFHTCCDVSFCYA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF-GWPSYGSRSSIAATHC--------SLHW 204
Cdd:cd15316   87 SLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYtGVNDDGLEELVNALNCvggcqiilNQNW 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 shsghrrvfaILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtMATAHPKRRSDSVNSqttiittstsvrRNQ 284
Cdd:cd15316  167 ----------VLVDFLLFFIPTFAMIILYGKIFLVAKQQARK--------IEMTSSKAESSSESY------------KDR 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966710671 285 VPRRKRrtlvggKAALTLAIIVGQFLLCWLPYFAFHL-HLSLGFshSTSEEAEGPVTWLAYSTFAVNPFFYGL 356
Cdd:cd15316  217 VARRER------KAAKTLGITVIAFLVSWLPYLIDVLiDAFMNF--ITPPYIYEICCWCAYYNSAMNPLIYAL 281
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
60-373 3.89e-13

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 69.21  E-value: 3.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLmpLGIVCGSPFFAGIVFS-----VLECRLYIFLNAFLISAS 134
Cdd:cd15299   13 LALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLI--IGVISMNLFTTYIIMNrwalgNLACDLWLSIDYVASNAS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 135 IFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGhrrvfA 214
Cdd:cd15299   91 VMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPDECFIQFLSEP-----I 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 215 ILFCT--LCFCVPAAIIIAVYGNVYKvahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvprrkrRT 292
Cdd:cd15299  166 ITFGTaiAAFYLPVTIMTILYWRIYK----------------------------------------------------ET 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 293 LVGGKAALTLAIIVGQFLLCWLPYFAfhLHLSLGFSHSTSEEAEGPVT-WLAYSTFAVNPFFYGLLNRQIREELcKMLFC 371
Cdd:cd15299  194 IKEKKAAQTLSAILLAFIITWTPYNI--MVLVNTFCDSCIPKTYWNLGyWLCYINSTVNPVCYALCNKTFRTTF-KMLLL 270

                 ..
gi 966710671 372 CR 373
Cdd:cd15299  271 CQ 272
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
67-365 5.50e-13

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 69.12  E-value: 5.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  67 GVLTVVVKVPHLRKFS-----LVCHLCIVDLLCAALLMPLGIV--CGSPFFAGIVFsvleCRLYIFLNAFLISASIFTVT 139
Cdd:cd15318   17 GNLFVVVTVSHFKALHtptnfLLLSLALADMLLGLTVLPFSTIrsVESCWYFGDSF----CRLHTCLDTLFCLTSIFHLC 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 140 VISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLlgLATVFGWpsygsrSSIAATHCSlHWSHSghrrVFAILFCT 219
Cdd:cd15318   93 FISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTV--YTSVFLY------TKAVEEGLA-ELLTS----VPCVGSCQ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 220 L------------CFCVPAAIIIAVYGNVYKVAhtaarergpipswtmatahpKRRSDSVNSQTTIIttstsvrrNQVPR 287
Cdd:cd15318  160 LlynklwgwlnfpVFFIPCLIMIGLYVKIFIVA--------------------KRQARAIASLLSDT--------NGASK 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 288 RKRrtlvggKAALTLAIIVGQFLLCWLPyFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15318  212 RER------KAAKTLGIAVGVYLLCWLP-FTIDTMVDSLLNFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
120-362 6.32e-13

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 68.83  E-value: 6.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAT- 198
Cdd:cd15927   73 CKLSEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTi 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 -HCSLHWSHSG--HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIpswtmatahpkrrsdsVNSQTtiit 275
Cdd:cd15927  153 qICYPYPQELGpnYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTRNIGSG----------------QNQAA---- 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 276 tstsvrRNQVPRRKrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHlslgFSHSTSEEAEGPVTW---------LAYST 346
Cdd:cd15927  213 ------QRQIEARK-------KVAKTVLAFVVLFAVCWLPRHVFMLW----FHFAPNGLVDYNAFWhvlkivgfcLSFIN 275
                        250
                 ....*....|....*.
gi 966710671 347 FAVNPFFYGLLNRQIR 362
Cdd:cd15927  276 SCVNPVALYLLSGSFR 291
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
52-365 6.72e-13

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 68.55  E-value: 6.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS---LVCHLCIVDLLcAALLMPLGI---VCGSPFFAGIVFSVLECRLYIF 125
Cdd:cd15104    4 VILAVLSPLIITGNLLVIVALLKLIRKKDTKsncFLLNLAIADFL-VGLAIPGLAtdeLLSDGENTQKVLCLLRMCFVIT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAflisASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLG-LATVFGWPSYGSRSSIaathCSLHw 204
Cdd:cd15104   83 SCA----ASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGfLPLISPQFQQTSYKGK----CSFF- 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 sHSGHRRVFAILFCTLCFcvPAA-IIIAVYGNVYKVAhtaarergpipswtmatahpkrrsdSVNSQTTIITTSTSVRrn 283
Cdd:cd15104  154 -AAFHPRVLLVLSCMVFF--PALlLFVFCYCDILKIA-------------------------RVHSRAIYKVEHALAR-- 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 qvPRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15104  204 --QIHPRRTLSDFKAARTVAVLIGCFLLSWLPFQITGLVQALCDECKLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRR 281

                 ..
gi 966710671 364 EL 365
Cdd:cd15104  282 AL 283
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-361 7.69e-13

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 68.61  E-value: 7.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  50 GLVVMVTLNAIALLANSGVLTVVV--KVPHLRKFSLVCHLCIVDLLCAALLMPLGIV--CGSPFFAGivfsVLECRLYIF 125
Cdd:cd15197    3 QLATLWVLFVFIVVGNSSVLFALWmrKAKKSRMNFFITQLAIADLCVGLINVLTDIIwrITVEWRAG----DFACKVIRY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYeakMTPWLSAAVMgfvwvASTLLGLATVFGWPS---YGSRS-SIAATHCS 201
Cdd:cd15197   79 LQVVVTYASTYVLVALSIDRYDAICHPMNF---SQSGRQARVL-----ICVAWILSALFSIPMliiFEKTGlSNGEVQCW 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 202 LHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSwTMATAHPKRRSDSvnsqttiittstsvr 281
Cdd:cd15197  151 ILWPEPWYWKVYMTIVAFLVFFIPATIISICYIIIVRTIWKKSKIQVTINK-AGLHDGSSRRSSS--------------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 282 RNQVPRRKRRTLvggkaALTLAIIVGqFLLCWLPYFAFHLHLSLGFSHSTSEEaegpvtwLAYSTF---------AVNPF 352
Cdd:cd15197  215 RGIIPRAKIKTI-----KMTFVIVTV-FIICWSPYFVFDLLDVFGLLPRSKTK-------IAAATFiqslaplnsAINPL 281

                 ....*....
gi 966710671 353 FYGLLNRQI 361
Cdd:cd15197  282 IYCLFSTHL 290
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
52-365 8.46e-13

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 68.21  E-value: 8.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK-------FSLVCHLCIVDLLCAALLMPLGIVCGSpfFAGIVFSVLECRLYI 124
Cdd:cd15002    1 LVPILLGVICLLGFAGNLMVIGILLNNARkgkpsliDSLILNLSAADLLLLLFSVPFRAAAYS--KGSWPLGWFVCKTAD 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAFLISASIFTVTVISIERYFYIVHPMRyEAKMTPWLSAAVMGFVWVASTLLGLATvfgWPSYGSRSSIAATHCSLHW 204
Cdd:cd15002   79 WFGHACMAAKSFTIAVLAKACYMYVVNPTK-QVTIKQRRITAVVASIWVPACLLPLPQ---WLFRTVKQSEGVYLCILCI 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGH--RRVFAILFCTLCFCVPAAIIIAVYGNVYKVAhtaarergpipswtmatahpKRRSdsvnsqttiittstsvRR 282
Cdd:cd15002  155 PPLAHefMSAFVKLYPLFVFCLPLTFALFYFWRAYGQC--------------------QRRG----------------TK 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 NQVPRRKRRtlvGGKAALTLAIIVGQFLLCWLPYFAFHLHLslgfSHSTSEEAEGPVTW------LAYSTFAVNPFFYGL 356
Cdd:cd15002  199 TQNLRNQIR---SRKLTHMLLSVVLAFTILWLPEWVAWLWL----IHIKSSGSSPPQLFnvlaqlLAFSISSVNPIIFLL 271

                 ....*....
gi 966710671 357 LNRQIREEL 365
Cdd:cd15002  272 MSEEFREGF 280
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
52-363 9.08e-13

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 68.28  E-value: 9.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMPL--GIVCGSPFFAGIVF-SVLECRLYIFLNA 128
Cdd:cd15082   18 ALMFVVTSLSLAENFAVMLVTFRFKQLRQ---PLNYIIVNLSVADFLVSLtgGTISFLTNARGYFFlGVWACVLEGFAVT 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHP---MRYEAKMtpwlSAAVMGFVWVASTLLGLATVFGWPSYgsRSSIAATHCSLHW- 204
Cdd:cd15082   95 FFGIVALWSLAVLAFERFFVICRPlgnIRLQGKH----AALGLLFVWTFSFIWTIPPVLGWSSY--TVSKIGTTCEPNWy 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSwtmaTAHPKRrsdsvnsqttiittstsvrrnQ 284
Cdd:cd15082  169 SGNMHDHTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGRLGN----ARKPER---------------------Q 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 285 VPRrkrrtlvggkaalTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15082  224 VTR-------------MVVVMIVAFMVCWTPYAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRK 289
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
87-362 9.10e-13

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 68.04  E-value: 9.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIvcGSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAA 166
Cdd:cd15323   42 LASADILVATLVMPFSL--ANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKA 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 167 VMGFVWVASTLLGLATVFGWpsYGSRSSIAATHCSLhwshsgHRRVFAILF-CTLCFCVPAAIIIAVYGNVYKVAHTaar 245
Cdd:cd15323  120 IIVTVWLISAVISFPPLISM--YRDPEGDVYPQCKL------NDETWYILSsCIGSFFAPCLIMILVYIRIYRVAKA--- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 246 ergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvpRRKRRTLVggkaaltLAIIVGQFLLCWLPYFafhlhlsl 325
Cdd:cd15323  189 -----------------------------------------REKRFTFV-------LAVVMGVFVVCWFPFF-------- 212
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 966710671 326 gFSHS----TSEEAEGPVT------WLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15323  213 -FSYSlygiCREACEVPEPlfkfffWIGYCNSSLNPVIYTIFNQDFR 258
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
68-233 1.46e-12

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 67.29  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  68 VLTVV--VKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISI 143
Cdd:cd15210   19 LLTVLalLRSKKLRTRTnaFIINLSISDLLFCAFNLPLAAS--TFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITL 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 144 ERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFG-WPSYGSRSSIAAthCSLHwsHSGHRRVFAILFCTLCF 222
Cdd:cd15210   97 NRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGiWGRFGLDPKVCS--CSIL--RDKKGRSPKTFLFVFGF 172
                        170
                 ....*....|.
gi 966710671 223 CVPAAIIIAVY 233
Cdd:cd15210  173 VLPCLVIIICY 183
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
52-365 1.63e-12

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 67.60  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLlCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSnmLVVNLAISDF-LMMIKMPIFIY--NSFYEGWALGPLGCQIYAFLGSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRyEAKMTPWLSAAVMGFVWVASTLLGLAT-VFGWPSYGSRSSIaaTHCSLHW-SHS 207
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALLPlLFGWGRYVPEGFL--TSCSFDYlTRD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 208 GHRRVFAILFCTLCFCVPAAIIIAVYGNVykVAHTAARERgpipswTMATAHPKRRSDSvnsqttiittstsVRRNQVPR 287
Cdd:cd15079  159 WNTRSFVATIFVFAYVIPLIIIIYCYSFI--VKAVFAHEK------ALREQAKKMNVVS-------------LRSNADAN 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 288 RKRRTLVGGKAALTlaiIVGQFLLCWLPY--------FAFHLHLSLGFShstseeaegpvTW---LAYSTFAVNPFFYGL 356
Cdd:cd15079  218 KQSAEIRIAKVALT---NVFLWFIAWTPYavvaligaFGNQSLLTPLVS-----------MIpalFAKTAACYNPIVYAI 283

                 ....*....
gi 966710671 357 LNRQIREEL 365
Cdd:cd15079  284 SHPKYRLEL 292
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
87-362 1.99e-12

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 66.89  E-value: 1.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGI---VCGSPFFAGIVfsvleCRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWL 163
Cdd:cd15322   42 LASADILVATLVIPFSLaneVMGYWYFGKVW-----CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 164 SAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAthCSLHwshsgHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTa 243
Cdd:cd15322  117 IKCIIFIVWVISAVISFPPLITIEKKSGQPEGPI--CKIN-----DEKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKN- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 244 arergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvpRRKRRTLVggkaaltLAIIVGQFLLCWLPYFaFHLHL 323
Cdd:cd15322  189 -------------------------------------------REKRFTFV-------LAVVIGVFVICWFPFF-FTYTL 217
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966710671 324 SLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15322  218 TAVCDCSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFR 256
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
51-363 2.18e-12

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 67.27  E-value: 2.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKV---PHLRKFS--LVCHLCIVDLLCAALLMPLGIVCGSPFFAGivfsvleCRLYIF 125
Cdd:cd15068    1 SVYITVELAIAVLAILGNVLVCWAVwlnSNLQNVTnyFVVSLAAADIAVGVLAIPFAITISTGFCAA-------CHGCLF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAF---LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGW-----PSYGSRSSIAA 197
Cdd:cd15068   74 IACFvlvLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWnncgqPKEGKNHSQGC 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 ----THCSLHWSHSGHRRVFAILFCtlCFCVPAAIIIAVYGNVYkvahtaarergpipswtMATAHPKRRSDSvnsqtti 273
Cdd:cd15068  154 gegqVACLFEDVVPMNYMVYFNFFA--CVLVPLLLMLGVYLRIF-----------------LAARRQLKQMES------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 274 ittstsvrrnQVP--RRKRRTLVGG-KAALTLAIIVGQFLLCWLPyfafhLHLSLGFSHsTSEEAEGPVTWLAY------ 344
Cdd:cd15068  208 ----------QPLpgERARSTLQKEvHAAKSLAIIVGLFALCWLP-----LHIINCFTF-FCPDCSHAPLWLMYlaivls 271
                        330       340
                 ....*....|....*....|
gi 966710671 345 -STFAVNPFFYGLLNRQIRE 363
Cdd:cd15068  272 hTNSVVNPFIYAYRIREFRQ 291
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
52-365 2.25e-12

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 67.09  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcaallmplgIVCGSPFFA-------GIVFSVLECRL 122
Cdd:cd15088    5 SVFGCICVVGLVGNGIVLYVLVRCSKLRTAPdiFIFNLAVADLL---------FMLGMPFLIhqfaidgQWYFGEVMCKI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 123 YIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLAT-VFGWPSYGSRSSiaaTHCS 201
Cdd:cd15088   76 ITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVwVYSSLIYFPDGT---TFCY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 202 LHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPipswtmatahpkrrsdsvnsqttiittstsvr 281
Cdd:cd15088  153 VSLPSPDDLYWFTIYHFILGFAVPLVVITVCY---ILILHRLARGVAP-------------------------------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 282 RNQVPRRKRRtlvgGKAALTLAIIVGQFLLCWLPYFAFHL-HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQ 360
Cdd:cd15088  198 GNQSHGSSRT----KRVTKMVILIVVVFIVCWLPFHVVQLvNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSEN 273

                 ....*
gi 966710671 361 IREEL 365
Cdd:cd15088  274 FRKRL 278
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
59-362 2.72e-12

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 67.02  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLlCAALLMPLGIVCGS-----PFFAGIvfsvleCRLYIFLNAFLI 131
Cdd:cd14985   12 LVGLLGNLFVVWVFLFPRGPKRVAdiFIANLAAADL-VFVLTLPLWATYTAnqydwPFGAFL------CKVSSYVISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 132 SASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLatvfgwPSYGSRSSIA-----ATHCSLHWSH 206
Cdd:cd14985   85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSL------PTFLLRSLQAienlnKTACIMLYPH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SGHRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPIPSwtmataHPKRRSDSVNsqttiittstsvrrnqvp 286
Cdd:cd14985  159 EAWHFGLSLELNILGFVLPLLIILTCY---FHIARSLRKRYERTGK------NGRKRRKSLK------------------ 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 287 rrkrrtlvggkaalTLAIIVGQFLLCWLPY--FAFHLHLSlGFSHSTSEEAEGPVTW-------LAYSTFAVNPFFYGLL 357
Cdd:cd14985  212 --------------IIFALVVAFLVCWLPFhfFKFLDFLA-QLGAIRPCFWELFLDLglpiatcLAFTNSCLNPFIYVFV 276

                 ....*
gi 966710671 358 NRQIR 362
Cdd:cd14985  277 DRRFR 281
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
48-365 2.80e-12

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 66.69  E-value: 2.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  48 MSGLVVMVtlnaiALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIvcgspFFA----GIVFSVLECR 121
Cdd:cd15394    6 LYSLVVLV-----GVVGNYLLIYVICRTKKMHNVTnfLIGNLAFSDMLMCATCVPLTL-----AYAfeprGWVFGRFMCY 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 122 LYIFLNAFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGLATVFGwPSYGSRSSIAATHCS 201
Cdd:cd15394   76 FVFLMQPVTVYVSVFTLTAIAVDRYYVTVYPLR--RRISRRTCAYIVAAIWLLSCGLALPAAAH-TYYVEFKGLDFSICE 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 202 LHWSHSG-HRRVFAILFCTLCFCVPAAIIIAVYGNV-YKVAHTAarergpIPSWTMATAHPKRRsdsvnsqttiittsts 279
Cdd:cd15394  153 EFWFGQEkQRLAYACSTLLITYVLPLLAISLSYLRIsVKLRNRV------VPGSMTQSQAEWDR---------------- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 280 vrrnqvpRRKRRTLvggkaaLTLAIIVGQFLLCWLPYFAFHLHLSLGFsHSTSEEAEGPVT----WLAYSTFAVNPFFYG 355
Cdd:cd15394  211 -------ARRRKTF------RLLVVVVVAFAICWLPLHIFNVIRDIDI-DLIDKQYFNLIQllchWLAMSSACYNPFLYA 276
                        330
                 ....*....|
gi 966710671 356 LLNRQIREEL 365
Cdd:cd15394  277 WLHDSFRGEL 286
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
51-362 2.86e-12

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 66.53  E-value: 2.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPL-GIVCGSPFFAGIVFSvleCRLYIFLN 127
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTnvFLASLATADLLLLVFCVPLkTAEYFSPTWSLGAFL---CKAVAYLQ 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAA--VMGFVWVASTLLGLATVFGWPS--YGSRSSIAATHCSLH 203
Cdd:cd15001   80 LLSFICSVLTLTAISIERYYVILHPMK--AKSFCTIGRArkVALLIWILSAILASPVLFGQGLvrYESENGVTVYHCQKA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WSHSGHRRVFAILFCTLCFCVPAAIIIAVYGnvykvahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrn 283
Cdd:cd15001  158 WPSTLYSRLYVVYLAIVIFFIPLIVMTFAYA------------------------------------------------- 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 qvpRRKRRTLVggkaaLTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPV----TWLAYSTFAVNPFFYGLLNR 359
Cdd:cd15001  189 ---RDTRKQVI-----KMLISVVVLFAVCWGPLLIDNLLVSFDVISTLHTQALKYMriafHLLSYANSCINPIIYAFMSK 260

                 ...
gi 966710671 360 QIR 362
Cdd:cd15001  261 NFR 263
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
52-362 3.75e-12

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 66.69  E-value: 3.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMplGIVCgSPFFAGIVFSV------LECRLYIF 125
Cdd:cd14992    2 ILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLM--ALFC-TPFNFTYVVSLsweyghFLCKIVNY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgWPS---YGSRSSIAATHCSL 202
Cdd:cd14992   79 LRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLY-YATtevLFSVKNQEKIFCCQ 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHSGH--RRVFAILFCTLCFCVPAAIIIAVYGNVYKvaHTAARErgpIPSWTMATAHPKRRsdsvnsqttiittstsv 280
Cdd:cd14992  158 IPPVDNKtyEKVYFLLIFVVIFVLPLIVMTLAYARISR--ELWFRK---VPGFSIKEVERKRL----------------- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 281 rrnqvpRRKRRTLvggkaaLTLAIIVGQFLLCWLPYFAFHL---HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLL 357
Cdd:cd14992  216 ------KCKRRVI------KMLVCVVVLFVICWLPFHLFFLlrdFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTL 283

                 ....*
gi 966710671 358 NRQIR 362
Cdd:cd14992  284 NNNFR 288
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
52-363 6.49e-12

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 65.28  E-value: 6.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIV-----DLLCAALLMPLGI---VCGSPFFAGIVfsvleCRLY 123
Cdd:cd15324    2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVslasaDILVATLVIPFSLaneVMGYWYFGSTW-----CAFY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpsygsRSSIAATHCSLH 203
Cdd:cd15324   77 LALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLL-------MTKHDEWECLLN 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 wshsghRRVFAILF-CTLCFCVPAAIIIAVYGNVYKVAHTaarergpipswtmatahpkrrsdsvnsqttiittstsvrr 282
Cdd:cd15324  150 ------DETWYILSsCTVSFFAPGLIMILVYCKIYRVAKM---------------------------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 nqvpRRKRRTLVggkaaltLAIIVGQFLLCWLP-YFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQI 361
Cdd:cd15324  184 ----REKRFTFV-------LAVVMGVFVLCWFPfFFTYSLHAVCRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDF 252

                 ..
gi 966710671 362 RE 363
Cdd:cd15324  253 RK 254
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
53-317 7.69e-12

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 65.85  E-value: 7.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVV-----KVPHLRkfSLVCHLCIVDLLCAALLMPLGIVCGSP--FFAGivfsVLECRLYIF 125
Cdd:cd15383    6 VTFVLFVLSACSNLAVLWSATrnrrrKLSHVR--ILILHLAAADLLVTFVVMPLDAAWNVTvqWYAG----DLACRLLMF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPM-RYEAKMTpwlSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHW 204
Cdd:cd15383   80 LKLFAMYSSAFVTVVISLDRHAAILNPLaIGSARRR---NRIMLCAAWGLSALLALPQLFLFHTVTATPPVNFTQCATHG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGHRR---VFAILFCTLcFCVPAAIIIAVYGNVykvahtaarergpipswTMATAHPKRRSDSVNSQTTIITTStsvr 281
Cdd:cd15383  157 SFPAHWQetlYNMFTFFCL-FLLPLLIMIFCYTRI-----------------LLEISRRMKEKKDSAKNEVALRSS---- 214
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 966710671 282 RNQVPRRKRRTLvggkaaLTLAIIVGQFLLCWLPYF 317
Cdd:cd15383  215 SDNIPKARMRTL------KMTIVIVSSFIVCWTPYY 244
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
59-363 8.18e-12

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 65.21  E-value: 8.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPhlrKFSLVCHLCIVDLLCAALLMPLGIvcgsPFFAG------IVFSVLECRLYIFLNAFLIS 132
Cdd:cd15972   12 VVGLGGNTLVIYVVLRYS---ASESVTNIYILNLALADELFMLGL----PFLAAqnalsyWPFGSFMCRLVMTVDAINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF--GWPSYGSRSSIAATHCSLHWshsghR 210
Cdd:cd15972   85 TSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIfsGVPGGMGTCHIAWPEPAQVW-----R 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 211 RVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSwtmatahpkrrsdsvnsqttiittstsvRRNQVPRRKR 290
Cdd:cd15972  160 AGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATST----------------------------KRRGSERKVT 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 291 RTLVggkaaltlaIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGP---VTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15972  212 RMVV---------IVVAAFVLCWLPFYALNI-VNLVCPLPEEPSLFGLyffVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
51-190 1.26e-11

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 65.56  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLGIVCGSPFfAGIVFSVLECRLYIFLNA 128
Cdd:cd15005    4 LTTLGLILCVSLAGNLLFSVLIVRDRSLHRapYYFLLDLCLADGLRSLACFPFVMASVRHG-SGWIYGALSCKVIAFLAV 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYG 190
Cdd:cd15005   83 LFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYT 144
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
85-365 2.53e-11

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 63.86  E-value: 2.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  85 CHLCIVDLLCAALLmPLGIVcGSPFFAGIVFSVLECRLY---IFLNAFlisASIFTVTVISIERYFYIVHPMRYEAKMTP 161
Cdd:cd14974   39 LNLALADFLFCLFL-PFLIV-YIAMGHHWPFGSVLCKLNsfvISLNMF---ASVFLLTAISLDRCLLVLHPVWAQNHRTV 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 162 WLSAAVMGFVWVastllgLATVFGWPSYGSRS-------SIAATHCSLH--WSHSGHRRVFAILFctLC-FCVPAAIIIA 231
Cdd:cd14974  114 RLASVVCVGIWI------LALVLSVPYFVFRDtvthhngRSCNLTCVEDydLRRSRHKALTVIRF--LCgFLLPLLIIAI 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 232 vygnVYKVAHTAARERGPIpswtmatahpkrrsdsvnsqttiittstsvrrnqvprRKRRTLvggkaaLTLAIIVGQFLL 311
Cdd:cd14974  186 ----CYSVIAVKLRRKRLA-------------------------------------KSSKPL------RVLLAVVVAFFL 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 312 CWLPYfafHLHLSLGFSHS-----TSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd14974  219 CWLPY---HVFALLELVAAaglpeVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
60-365 2.54e-11

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 63.82  E-value: 2.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFSLV--CHLCIVDLLCAaLLMPLGIVcgspFFAGI---VFSVLECRLYIFLNAFLISAS 134
Cdd:cd14982   13 LGLLGNILALWVFLRKMKKRSPTTIymINLALADLLFV-LTLPFRIY----YYLNGgwwPFGDFLCRLTGLLFYINMYGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 135 IFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVastLLGLATVfgwPSYGSRSSIA----ATHCSLHWSHSGHR 210
Cdd:cd14982   88 ILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWI---LVLVASV---PLLLLRSTIAkennSTTCFEFLSEWLAS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 211 RVFAILF-CTLCFCVPAAIIIAVYGnvyKVAHTAARergpipswtmatahpkrrsdsvnsqttiittstsvRRNQVPRRK 289
Cdd:cd14982  162 AAPIVLIaLVVGFLIPLLIILVCYS---LIIRALRR-----------------------------------RSKQSQKSV 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 290 RRTlvggKAALTLAIIVGQFLLCWLPYfafHLHLSLGFSHSTSEEAEGPVT-----------WLAYSTFAVNPFFYGLLN 358
Cdd:cd14982  204 RKR----KALRMILIVLAVFLVCFLPY---HVTRILYLLVRLSFIADCSARnslykayritlCLASLNSCLDPLIYYFLS 276

                 ....*..
gi 966710671 359 RQIREEL 365
Cdd:cd14982  277 KTFRKRL 283
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
58-365 2.54e-11

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 63.77  E-value: 2.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  58 NAIALLANSGVLTVVV------KVPhlrKFsLVCHLCIVDLLCAALLMPLGIV----CGSPFFAGIVFSV-LECRLYIFL 126
Cdd:cd15136   11 FLLALVGNIIVLLVLLtsrtklTVP---RF-LMCNLAFADFCMGIYLGLLAIVdaktLGEYYNYAIDWQTgAGCKTAGFL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYgSRSSIaathCSLHWSH 206
Cdd:cd15136   87 AVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSY-SKTSI----CLPFETE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SGHRRVFAILfcTLCFCVPAAIIIAV-YGNVYKVAhtaareRGPIPSWtmatahpkRRSDSvnsqttiittstsvrrnqv 285
Cdd:cd15136  162 TPVSKAYVIF--LLLFNGLAFLIICGcYIKIYLSV------RGSGRAA--------NSNDT------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 286 prrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEgPVTWLAY--STFAvNPFFYGLLNRQIRE 363
Cdd:cd15136  207 -----------RIAKRMALLVFTDFLCWAPIAFFGLTAAFGLPLISVSNAK-ILLVFFYplNSCA-NPFLYAIFTKQFRR 273

                 ..
gi 966710671 364 EL 365
Cdd:cd15136  274 DC 275
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
51-360 2.84e-11

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 63.60  E-value: 2.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAI---ALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLcaallmplgiVC--GSPF-FAGI-----VFSV 117
Cdd:cd15086    1 TVVAVFLGFIltfGFLNNLLVLVLFCKYKVLRSpiNLLLLNISLSDLL----------VCvlGTPFsFAAStqgrwLIGE 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 118 LECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMryEAKMTPWLSAAV-MGFVWVASTLLGLATVFGWPSYGSRSsiA 196
Cdd:cd15086   71 HGCRWYGFANSLFGIVSLISLAVLSYERYCTLLRPT--EADVSDYRKAWLgVGGSWLYSLLWTLPPLLGWSSYGPEG--P 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 197 ATHCSLHWSHSGHRRVFAILfCTLCFC--VPAAIIIAVYGNVYkvahTAARERGPIpswtmatahpkrrsdsvnsqttii 274
Cdd:cd15086  147 GTTCSVQWTSRSANSISYII-CLFIFCllLPFLVMVYCYGRLL----YAIKQVGKI------------------------ 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 275 ttstsvRRNQVPRRKRRTLvggkaaLTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFY 354
Cdd:cd15086  198 ------NKSTARKREQHVL------LMVVTMVICYLLCWLPYGVMALLATFGKPGLVTPVASIVPSILAKSSTVVNPIIY 265

                 ....*.
gi 966710671 355 GLLNRQ 360
Cdd:cd15086  266 VFMNKQ 271
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
61-365 2.95e-11

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 63.62  E-value: 2.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  61 ALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcaallmpLGIVCGSP-----FFAGIVFSVLECRLYIFLNAFLISA 133
Cdd:cd15012   13 CFFGNLLVILVVTSHRRMRTITnfFLANLAVADLC-------VGIFCVLQnlsiyLIPSWPFGEVLCRMYQFVHSLSYTA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSY----GSRSSIAATHCSLHwsHSGH 209
Cdd:cd15012   86 SIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVeilvTQDGQEEEICVLDR--EMFN 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvPRRK 289
Cdd:cd15012  164 SKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIE--------------------------------------ARRK 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 290 RRTLvggkaaltLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEG---PVTWLA-YSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15012  206 VVRL--------LVAVVVSFALCNLPYHARKMWQYWSEPYRCDSNWNAlltPLTFLVlYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
87-363 4.44e-11

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 63.02  E-value: 4.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIvcGSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAA 166
Cdd:cd15321   48 LAAADILVATLIIPFSL--ANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKC 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 167 VMGFVWVASTLLGLATVFgWPSYGSRSSIAATHCSLhwshsgHRRVFAILFCTLC-FCVPAAIIIAVYGNVYKVAHTaar 245
Cdd:cd15321  126 IILIVWLIAAVISLPPLI-YKGKQKDEQGGLPQCKL------NEEAWYILSSSIGsFFAPCLIMILVYLRIYLIAKN--- 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 246 ergpipswtmatahpkrrsdsvnsqttiittstsvrrnqvpRRKRRTLVggkaaltLAIIVGQFLLCWLPYFAFHlhlSL 325
Cdd:cd15321  196 -----------------------------------------REKRFTFV-------LAVVIGVFVLCWFPFFFSY---SL 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 966710671 326 GFSHSTSEEAEGPV----TWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15321  225 GAICPELCKVPHSLfqffFWIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
60-363 7.41e-11

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 62.49  E-value: 7.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKvphLRKFSLVCHLCIVDLLCAALLMPLGIvcgsPFF------AGIVFSVLECRLYIFLNAFLISA 133
Cdd:cd15094   13 VGLVGNGLVIYVVLR---YAKMKTVTNLYILNLAVADECFLIGL----PFLivtmilKYWPFGAAMCKIYMVLTSINQFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLAtVFGWPSYGSRSSIAAthCSLHWSHSGH---R 210
Cdd:cd15094   86 SSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLP-IILYASTVPDSGRYS--CTIVWPDSSAvngQ 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 211 RVFAILFCTLCFCVPAAIIIAVYGNVYKvahtaarergpipswTMATAHPKRRSdsvnsqttiittstsvRRNQVPRRKR 290
Cdd:cd15094  163 KAFTLYTFLLGFAIPLLLISVFYTLVIL---------------RLRTVGPKNKS----------------KEKRRSHRKV 211
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 291 RTLVggkaaLTlaiIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPV----TWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15094  212 TRLV-----LT---VISVYIICWLPYWAFQVHLIFLPPGTDMPKWEILMflllTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
56-363 1.90e-10

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 61.49  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  56 TLNAIALLANSGVLTVVVKVPHLRK---FSLVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLE-------CRLYIF 125
Cdd:cd14980    9 IIGILALIGNILVIIWHISSKKKKKkvpKLLIINLAIADFLMGIYLLIIAIA--DQYYRGRYAQYSEewlrsppCLLACF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEaKMTPWLSAAVMGFVWVAS---TLLGLATVFGWPSYG---SRSSIaath 199
Cdd:cd14980   87 LVSLSSLMSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSiifAAIPILYSINQPGDNrlyGYSSI---- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 200 CSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAvYGNVYKVAHTAARErgpipswtmatahpkrrsdsvnsqttiittsts 279
Cdd:cd14980  162 CMPSNVSNPYYRGWLIAYLLLTFIAWIIICIL-YILIFISVRKSRKS--------------------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 280 VRRNQVPRRKRrtlvggkAALTLAIIVGQFLLCWLPYFAFHLHLSLGfSHSTSEEAEGPVTWLAY---StfAVNPFFYGL 356
Cdd:cd14980  208 ARRSSSKRDKR-------IAIRLALILITDLICWLPYYIVIFSGLLT-STEIDIHVLQFIAILALplnS--AINPYLYTL 277

                 ....*..
gi 966710671 357 LNRQIRE 363
Cdd:cd14980  278 TTPTFKR 284
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
51-358 1.93e-10

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 61.29  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcaallmplGIVCGSPFFAGIVFSV------LECRL 122
Cdd:cd14964    2 TIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTrlLLASLAACDLL--------ASLVVLVLFFLLGLTEassrpqALCYL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 123 YIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSL 202
Cdd:cd14964   74 IYLLWYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHsghrrVFAILFCTLCFCVPaaIIIAVYGNVykvahtaarergpipswtmATAHPKRRSDsvnsqttiittstsvrR 282
Cdd:cd14964  154 CTTI-----YLTWGFLLVSFLLP--LVAFLVIFS-------------------RIVLRLRRRV----------------R 191
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 283 NQVPRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLN 358
Cdd:cd14964  192 AIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
60-363 2.88e-10

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 60.77  E-value: 2.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcaallmpLGIVCGSpfFAGIVFSVLE-------CRLYIFLNAFL 130
Cdd:cd15096   13 VGLIGNSLVILVVLSNQQMRSTTniLILNLAVADLL-------FVVFCVP--FTATDYVLPTwpfgdvwCKIVQYLVYVT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWP-SYGSRSSIAATHCSLHWSHSGH 209
Cdd:cd15096   84 AYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGvVSYGFSSEAYSYCTFLTEVGTA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILFCTLCFCVPAAIIIAVYGNVYKVAhtaarergpipsWTMATAHPKRRSDSVnsqttiittstsvrrnqvpRRK 289
Cdd:cd15096  164 AQTFFTSFFLFSYLIPLTLICVLYMLMLRRL------------RRQKSPGGRRSAESQ-------------------RGK 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 290 RRtlvggkAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW--LAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15096  213 RR------VTRLVVVVVVVFAICWLPIHIILLLKYYGVLPETVLYVVIQILSncLAYGNSCVNPILYAFLSQNFRK 282
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
59-365 2.90e-10

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 61.09  E-value: 2.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcaaLLMPLGIVCGSPFFA-GIVFSVLECRLYIFLNAFLISASI 135
Cdd:cd15123   12 SVGILGNAILIKVFFKIKSMQTVPniFITSLAFGDLL---LLLTCVPVDATRYIAdTWLFGRIGCKLLSFIQLTSVGVSV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 136 FTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGHRRVFAI 215
Cdd:cd15123   89 FTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAPYPVSEKILQE 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 216 LFCTLCFCV----PAAIIIAVYgnvYKVAHTAARERGPIPSWTMATAhpkrrsdsvnsqttiittstsvrRNQVPRRKRr 291
Cdd:cd15123  169 IHSLLCFLVfyiiPLSIISVYY---FLIARTLYKSTFNMPAEEHSHA-----------------------RKQIESRKR- 221
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 292 tlvggkAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW-----LAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15123  222 ------VAKTVLVLVALFAFCWLPNHILYLYRSFTYHTSVDSSAFHLIATifsrvLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
118-363 3.75e-10

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 60.04  E-value: 3.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 118 LECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAA 197
Cdd:cd15300   71 LACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKRTVPE 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 THCSLHWSHSGhrrvfAILFCT--LCFCVPAAIIIAVYGNVYKvahtaarergpipswtmatahpkrrsdsvnsqttiit 275
Cdd:cd15300  151 RECQIQFLSEP-----TITFGTaiAAFYIPVSVMTILYCRIYK------------------------------------- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 276 tstsvrrnqvprrkrRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLhlslgfsHSTSEEAEGPVT------WLAYSTFAV 349
Cdd:cd15300  189 ---------------ETIKERKAAQTLSAILLAFIITWTPYNIMVL-------VSTFCSDCIPLTlwhlgyWLCYVNSTV 246
                        250
                 ....*....|....
gi 966710671 350 NPFFYGLLNRQIRE 363
Cdd:cd15300  247 NPMCYALCNKTFRK 260
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
124-362 3.76e-10

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 60.72  E-value: 3.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAF---LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWpsygSRSSIAATHC 200
Cdd:cd15069   72 LFLACFvlvLTQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGW----NKAMSATNNS 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSH-SGHRRVF-AILFCTL-------------CFCVPAAIIIAVYGNVYKVAhtaarergpipswtmatahpkrrsd 265
Cdd:cd15069  148 TNPADHgTNHSCCLiSCLFENVvpmsymvyfnffgCVLPPLLIMLVIYIKIFLVA------------------------- 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 266 svnsqttiittSTSVRRNQVPRRKRRTLVGG-KAALTLAIIVGQFLLCWLPYFAFHL--HLSLGFSHSTSEEAEGPVTWL 342
Cdd:cd15069  203 -----------CRQLQRTELMDHSRTTLQREiHAAKSLAIIVGIFALCWLPVHILNCitLFQPEFSKSKPKWAMNVAILL 271
                        250       260
                 ....*....|....*....|
gi 966710671 343 AYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15069  272 SHANSVVNPIVYAYRNRDFR 291
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
59-365 4.06e-10

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 60.30  E-value: 4.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcaaLLMPLGIVCGSPFFAG-IVFSVLECRLYIFLNAFLISASI 135
Cdd:cd15124   12 LIGLIGNITLIKIFCTVKSMRNVPnlFISSLALGDLL---LLVTCAPVDASRYLADeWLFGRVGCKLIPFIQLTSVGVSV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 136 FTVTVISIERYFYIVHPMRYEAK---MTPWLSAAvmgFVWVASTLLGLA-TVFG--WPSYGSRSSIAATHCSlHWSHSG- 208
Cdd:cd15124   89 FTLTALSADRYKAIVRPMDIQASnalMKICLKAA---LIWILSMLLAIPeAVFSdlHPFYDKSTNKTFVSCA-PYPHSNe 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 -HRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPIPswTMATAHPKRrsdsvnsqttiittstsvrrnQVPR 287
Cdd:cd15124  165 lHPKIHSMASFLIFYVIPLSIISVYY---YFIAKNLIRSAYNLP--VEGNVHVRR---------------------QIES 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 288 RKRrtlvggkAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVT----WLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15124  219 RKR-------LAKTVLVFVGLFAFCWLPNHIIYLYRSYHYSEVDTSMLHFVSSicarILAFTNSCVNPFALYLLSKSFRK 291

                 ..
gi 966710671 364 EL 365
Cdd:cd15124  292 QF 293
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
87-363 4.75e-10

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 60.24  E-value: 4.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIV---CGSPFFAGIVfsvlECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWL 163
Cdd:cd15133   42 LAVSDLLVLLLGMPLELYelwQNYPFLLGSG----GCYFKTFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPR 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 164 SAAVMGFVWVASTLLGL--ATVFGWPSYGSR--SSIAATHCSLHWSHSGHRRVFAILFctlcFCVPAAIIIAVYgnvYKV 239
Cdd:cd15133  118 VTRVLGCVWGVSMLCALpnTSLHGIKFLGSGvpASAQCTVRKPQAIYNMIPQHTGHLF----FVLPMAVISVLY---LLM 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 240 AHTAARERGpipswTMATAHPKRRSDSVNsqttiittstsvRRNQVPRRKRrtlvggKAALTLAIIVGQFLLCWLPYFAF 319
Cdd:cd15133  191 ALRLARERG-----LDATGAGSKIGTRTG------------QLLQHPRTRA------QVTKMLFILVVVFAICWAPFHID 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 966710671 320 HLHLSL-----GFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15133  248 RLMWSFisdwtDNLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFRE 296
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
86-365 6.13e-10

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 59.72  E-value: 6.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  86 HLCIVDLLCAA----LLMPLGIVCGSPFFAgivfsvLECRLY---IFLNAFlisASIFTVTVISIERYFYIVHPMRYEAK 158
Cdd:cd15114   40 NLAVADLLCCLslpiLAVPIAQDGHWPFGA------AACKLLpslILLNMY---ASVLLLTAISADRCLLVLRPVWCQNH 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 159 MTPWLSAAVMGFVWVastllgLATVFGWPSYGSRS-----SIAATHCSLHWSHS-GHRRVFAILFCTLCFCVPAAIIIAV 232
Cdd:cd15114  111 RRARLAWIACGAAWL------LALLLTVPSFIYRRihqehFPEKTVCVVDYGGStGVEWAVAIIRFLLGFLGPLVVIASC 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 233 YGNVYkvAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvpRRKRRTLVggkaaLTLAIIVGqFLLC 312
Cdd:cd15114  185 HGVLL--VRTWSRRR---------------------------------------QKSRRTLK-----VVTAVVVG-FFLC 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 313 WLPYFAFHLHLSLGFSHSTSE----EAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15114  218 WTPYHVVGLIIAASAPNSRLLanalKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
120-365 6.88e-10

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 59.37  E-value: 6.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSY-GSRSSIAAT 198
Cdd:cd15302   74 CDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFtGQGRSLPEG 153
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 HCSLHWSHSGhrrVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpkrrsdsvnsqttiittst 278
Cdd:cd15302  154 ECYVQFMTDP---YFNMGMYIGYYWTTLIVMLILYAGIYRAANRAR---------------------------------- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 279 svrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAfhLHLSLGFShstseEAEGPVT--------WLAYSTFAVN 350
Cdd:cd15302  197 ------------------KALRTITFILGAFVICWTPYHI--LATIYGFC-----EAPPCVNetlytisyYLCYMNSPIN 251
                        250
                 ....*....|....*
gi 966710671 351 PFFYGLLNRQIREEL 365
Cdd:cd15302  252 PFCYALANQQFKKTF 266
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
52-371 7.47e-10

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 59.49  E-value: 7.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCAALLMPLgivCGSPF------FAGIVFSVLECRLYIF 125
Cdd:cd15084   15 VLMGMVVALASFVNGLVIVVSIKYKKLRS---PLNYILVNLAVADLLVTL---FGSSVsfsnniVGFFVFGKTMCEFEGF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPM---RYEAKMtpwlsaAVMG--FVWVASTLLGLATVFGWPSY---GSRSSiaa 197
Cdd:cd15084   89 MVSLTGIVGLWSLAILAFERYLVICKPMgdfRFQQRH------AVSGcaFTWGWSLLWTSPPLFGWSSYvpeGLRTS--- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 thCSLHW--SHSGHRRVFAILFCTlCFCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiit 275
Cdd:cd15084  160 --CGPNWytGGTNNNSYILALFVT-CFALPLSTIIFSYSNLLLTLRAVAAQQ---------------------------- 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 276 tstsvRRNQVPRRKRRTLVGGKAALTLAiivgqFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYG 355
Cdd:cd15084  209 -----KESETTQRAEKEVTRMVIAMVMA-----FLICWLPYATFAMVVATNKDVVIQPTLASLPSYFSKTATVYNPIIYV 278
                        330
                 ....*....|....*.
gi 966710671 356 LLNRQIREELCKMLFC 371
Cdd:cd15084  279 FMNKQFRSCLLELLCC 294
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
51-243 8.90e-10

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 59.17  E-value: 8.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKV--PHLRKFSLVCHLCIVDLLCAAL--LMPLGIVCGSPFFAGIVFsvleCRLYIFL 126
Cdd:cd15196    4 IAVLATILVLALFGNSCVLLVLYRRrrKLSRMHLFILHLSVADLLVALFnvLPQLIWDITYRFYGGDLL----CRLVKYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEaKMTPWLSAAVMGFVWVASTLLGLATVFGWpSYGSRSSIaATHCSLHWSH 206
Cdd:cd15196   80 QVVGMYASSYVLVATAIDRYIAICHPLSSH-RWTSRRVHLMVAIAWVLSLLLSIPQLFIF-SYQEVGSG-VYDCWATFEP 156
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966710671 207 SGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTA 243
Cdd:cd15196  157 PWGLRAYITWFTVAVFVVPLIILAFCYGRICYVVWRA 193
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
52-363 9.72e-10

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 59.48  E-value: 9.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15403    5 IVMILMIAIGFLGNAIVCLIVYQKPAMRSAInlLLATLAFSDIMLSLLCMPFTAV--TIITVDWHFGAHFCRISAMLYWF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVhpmRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWP--SYGSRssiaATHCSLHWSHS 207
Cdd:cd15403   83 FVLEGVAILLIISVDRFLIIV---QRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTlvEVPAR----APQCVLGYTES 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 208 GHRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARErgpipswtmaTAHPKRRSDSVN-SQTTIITTSTSVRRNQVp 286
Cdd:cd15403  156 PADRVYAVLLVVAVFFVPFSIMLYSY---LCILNTVRRN----------AVRIHNHADSLClSQVSKLGLMGLQRPHQM- 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 287 rrKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLH--LSLGFSHSTSEEAEGP-VTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15403  222 --NVDMSFKTRAFTTILILFVGFSLCWLPHTVFSLLsvFSRRFYYSSSFYPISTcVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
103-362 1.14e-09

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 59.07  E-value: 1.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 103 IVCGSPFFAGI------VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWvast 176
Cdd:cd15097   51 ILFCVPFQATIyslegwVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIW---- 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 177 llGLATVFGWP--SYGSRSSIAATH-CSLHWSHSgHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAArerGPIpsw 253
Cdd:cd15097  127 --GLSLLFAGPylSYYDLIDYANSTvCMPGWEEA-RRKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLWTAV---DPL--- 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 254 tmATAHPKRRSdsvnsqttiittstsvrrnqvprrKRRTlvgGKAALTLAIIvgqFLLCWLPYFAFHLHLSLG-FSHSTS 332
Cdd:cd15097  198 --EAMSESKRA------------------------KRKV---TKMIIIVTAL---FCLCWLPHHVVILCYLYGdFPFNQA 245
                        250       260       270
                 ....*....|....*....|....*....|.
gi 966710671 333 EEAEGPVT-WLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15097  246 TYAFRLLShCMAYANSCLNPIVYALVSKHFR 276
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
53-364 1.17e-09

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 59.02  E-value: 1.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAalLMPLGIVCGSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15209    6 VLIVTIVVDVLGNLLVILSVLRNKKLRNAGniFVVSLSVADLVVA--IYPYPLILHAIFHNGWTLGQLHCQASGFIMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF-GWPSYGSRSsiaaTHCSLHWSHSGh 209
Cdd:cd15209   84 VIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFiGSLQYDPRI----YSCTFAQTVST- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 rrVFAILFCTLCFCVPAAIIIAVYGNVykvahtaarergpipsWTMATAHPKRrsdsvnsqttiittstsVRRNQVPRRK 289
Cdd:cd15209  159 --VYTITVVVIHFLLPLLIVSFCYLRI----------------WVLVLQVRQR-----------------VKPDQRPKLK 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 290 RRTLvggKAALTLAIIVGQFLLCWLPYFAfhlhLSLGFSHSTSEEAEGPVTWL-------AYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15209  204 PADV---RNFLTMFVVFVLFAVCWAPLNF----IGLAVAINPKEMAPKIPEWLfvasyfmAYFNSCLNAIIYGLLNQNFR 276

                 ..
gi 966710671 363 EE 364
Cdd:cd15209  277 KE 278
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
109-362 1.20e-09

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 59.19  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 109 FFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYE-AKMTPWLSAAVMGfVWVASTLLGLA-TVFGW 186
Cdd:cd15125   62 FYEEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYKAIVNPMDIQtSSAVLRTCLKAIA-IWVVSVLLAVPeAVFSE 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 187 PSYGSRSSIAATHCSLHWSHSG--HRRVFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPIPSwtMATAHPKRrs 264
Cdd:cd15125  141 VAHIMPDDNTTFTACIPYPQTDemHPKIHSVLIFLVYFLIPLAIISIYY---YHIAKTLIKSAHNIPG--EYSEHSKR-- 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 265 dsvnsqttiittstsvrrnQVPRRKRrtlvggkAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW--- 341
Cdd:cd15125  214 -------------------QMETRKR-------LAKIVLVFVGLFAFCWFPNHVLYMYRSFNYNEIDSSLGHMIVTLvar 267
                        250       260
                 ....*....|....*....|..
gi 966710671 342 -LAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15125  268 vLSFCNSCVNPFALYLLSESFR 289
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
52-363 1.42e-09

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 58.84  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVtlnaIALLANSGVLTVVVKVPHLRK---FSLVcHLCIVDLLCAALLMPLGIVcgsPFFAGIVFSVLE--CRLYIFL 126
Cdd:cd14997    9 VIFV----VGVLGNVLVGIVVWKNKDMRTptnIFLV-NLSVADLLVLLVCMPVALV---ETWAREPWLLGEfmCKLVPFV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF------GWPSYGSRSSIAATHC 200
Cdd:cd14997   81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFitefkeEDFNDGTPVAVCRTPA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWshsghrRVFAILFCT-LCFCVPAAIIIAVYGNVykvahtaARERgpipSWTMATAHPKRRSDSVNSQttiittsts 279
Cdd:cd14997  161 DTFW------KVAYILSTIvVFFVVPLAILSGLYSVI-------CRRL----VGHPALESRRADAANRHTL--------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 280 vrrnqvprRKRRTLVggkaaLTLAIIVGQFLLCWLPYFAFHLHLSlgFSHSTSEEAEGPVTWLAYSTF---------AVN 350
Cdd:cd14997  215 --------RSRRQVV-----YMLITVVVLFFVCLLPFRVVTLWII--FAPDEDLQALGLEGYLNLLVFcrvmvylnsALN 279
                        330
                 ....*....|...
gi 966710671 351 PFFYGLLNRQIRE 363
Cdd:cd14997  280 PILYNLMSTKFRS 292
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-362 2.11e-09

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 58.02  E-value: 2.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRyeakmtPWLSAA----VMGFVWVastllgLATVFGWPS-YGSRSS 194
Cdd:cd16003   73 CRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPLK------PRLSATatkvVIGSIWI------LAFLLAFPQcLYSKTK 140
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 195 I--AATHCSLHWSHSGHRR-VFAILFCTLCFCVPaaiiIAVYGNVYKVAHTAARErGPIPSWTmatahpkrrSDSVNSQT 271
Cdd:cd16003  141 VmpGRTLCFVAWPGGPDQHfTYHIIVIVLVYCLP----LLVMGITYTIVGITLWG-GEIPGDT---------SDKYHEQL 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 272 tiittstsvrrnqvpRRKRrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEG---PVTWLAYSTFA 348
Cdd:cd16003  207 ---------------RAKR------KVVKMMIIVVLTFAICWLPYHIYFIVTGLYQQLNRWKYIQQvylASFWLAMSSTM 265
                        250
                 ....*....|....
gi 966710671 349 VNPFFYGLLNRQIR 362
Cdd:cd16003  266 YNPIIYCCLNKRFR 279
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
60-365 2.20e-09

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 57.99  E-value: 2.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFSLVC--HLCIVDLLCAALLmplgivcgsPFFA-----GIVFSVLECRLYIFLnaFLIS 132
Cdd:cd14984   13 LGLVGNSLVLLVLLYYRKLRSMTDVYllNLALADLLFVLTL---------PFWAvyaadGWVFGSFLCKLVSAL--YTIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 --ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL-ATVFgwpsYGSRSSIAATHCSLHWSHSGH 209
Cdd:cd14984   82 fySGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLpEFIF----SQVSEENGSSICSYDYPEDTA 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RR---VFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGpipswtmatahpkrrsdsvnsqttiittstsvrrnqvp 286
Cdd:cd14984  158 TTwktLLRLLQNILGFLLPLLVMLFCY---SRIIRTLLRARN-------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 287 RRKRRTLVggkaaLTLAIIVgQFLLCWLPY----FAFHLHLSLGFSHSTSEEAEGPVTW-----LAYSTFAVNPFFYGLL 357
Cdd:cd14984  197 HKKHRALR-----VIFAVVV-VFFLCWLPYnivlLLDTLQLLGIISRSCELSKSLDYALqvtesLAFSHCCLNPVLYAFV 270

                 ....*...
gi 966710671 358 NRQIREEL 365
Cdd:cd14984  271 GVKFRKYL 278
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
60-362 2.29e-09

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 58.30  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15981   13 LCMVGNGLVCFIVLKNRQMRTVTnmFILNLAVSDLLVGIFCMPTTLV--DNLITGWPFDNAMCKMSGLVQGMSVSASVFT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVastllgLATVFGWPSYGSRSSIAATH---------------CSL 202
Cdd:cd15981   91 LVAIAVERFRCIVHPFR--QKLTLRKAIVTIVIIWV------LALIIMCPSAVTLTVTREEHhfmvddynnsyplysCWE 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNV-YKVAHTAARERGPIPSwtmataHPKRRsdsvnsqttiittstsvr 281
Cdd:cd15981  163 AWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIaFKLFKSSAPIRGSQGE------EEEGR------------------ 218
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 282 rnQVPRRKRRTLVggkaalTLAIIVGQFLLCWLPYFAFHL-----HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGL 356
Cdd:cd15981  219 --RVSKRKIKVIN------MLIIVALFFTLSWLPLWTLMLltdygHLSEDQLNLVTVYVFPFAHWLAFFNSSVNPIIYGY 290

                 ....*.
gi 966710671 357 LNRQIR 362
Cdd:cd15981  291 FNENFR 296
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
120-362 2.34e-09

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 57.91  E-value: 2.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATH 199
Cdd:cd15301   73 CDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSWPYIEGKRTVPAGT 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 200 CSLHWSHSGHRrvfaILFCTLC--FCVPAAIIIAVYGNVYKVahtaarergpipswtmaTAHPKRRSDSvnsqttiitts 277
Cdd:cd15301  153 CYIQFLETNPY----VTFGTALaaFYVPVTIMCILYWRIWRE-----------------TKKRQKKQES----------- 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 278 tsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSL-GFSHSTSEEAEGPVTWLAYSTFAVNPFFYGL 356
Cdd:cd15301  201 -------------------KAAKTLSAILLAFIVTWTPYNVLVLIKAFfPCSDTIPTELWDFSYYLCYINSTINPLCYAL 261

                 ....*.
gi 966710671 357 LNRQIR 362
Cdd:cd15301  262 CNAAFR 267
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
114-363 2.45e-09

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 58.11  E-value: 2.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 114 VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL--ATVFG-----W 186
Cdd:cd15134   68 VFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALpfAIQTRivyleY 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 187 PSYGSRSSIAATHCSLHWSHSGHRRVFaILFCTLCFCVPAAIIIAVYGnvykvaHTAARergpIPSWTMATAHPKRRSDS 266
Cdd:cd15134  148 PPTSGEALEESAFCAMLNEIPPITPVF-QLSTFLFFIIPMIAIIVLYV------LIGLQ----LRRSTLLRRGQRSVSGG 216
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 267 vnsqttiittstsVRRNQVPRRKRRTLVggkaaltlAIIVGqFLLCWLPyfaFHLHLSLGFSHSTSEEAEGPV-TWLAY- 344
Cdd:cd15134  217 -------------RRSSQSRRTVLRMLV--------AVVVA-FFICWAP---FHAQRLLTVYAKNMTPPYLFInRILFYi 271
                        250       260
                 ....*....|....*....|....*
gi 966710671 345 ------STFAVNPFFYGLLNRQIRE 363
Cdd:cd15134  272 sgvlyyVSSTVNPILYNVMSAKYRQ 296
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
53-361 2.83e-09

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 57.86  E-value: 2.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMP---LGIVCGSPFFAGIVFsvleCRLYIFLN 127
Cdd:cd15212    6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTnaFILSLSLSDLLTALLCLPfafLTLFSRPGWLFGDRL----CLANGFFN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVastllgLATVFGWPSY---GSRSSIAAT---HCS 201
Cdd:cd15212   82 ACFGIVSTLTMTLISFDRYYAIVRQPQ--GKIGRRRALQLLAAAWL------TALGFSLPWYllaSAPEYYEKLgfyHCL 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 202 --LHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTaarergpipswtmatahpkrrSDSvnsqttiittstS 279
Cdd:cd15212  154 yvLHSGPSRLGAAYSSVLIVLCYLLPFALMCFCHYNICKTVRL---------------------SES------------R 200
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 280 VRRNQVPRRKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGfSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNR 359
Cdd:cd15212  201 VRPVTTYAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLVAAAG-GYQFPPLMDTVAIWMAWANGAINPLIYAIRNP 279

                 ..
gi 966710671 360 QI 361
Cdd:cd15212  280 NI 281
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
60-362 3.11e-09

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 57.61  E-value: 3.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcaaLLMPLGIVCGSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15970   13 VGLCGNSMVIYVILRYAKMKTATniYILNLAIADEL---LMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYC 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLA-TVFGWPSYGSRSSIAathCSLHWSHSGHR--RVFA 214
Cdd:cd15970   90 LTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPiIIFSNTAPNSDGSVA---CNMQMPEPSQRwlAVFV 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 215 ILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGpipsWtmatahpkrrsdsvnsqttiittstsvrrnQVPRRKRRtlv 294
Cdd:cd15970  167 VYTFLMGFLLPVIAICLCYILIIVKMRVVALKAG----W------------------------------QQRKRSER--- 209
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 295 ggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVtwLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15970  210 --KITLMVMMVVTVFVICWMPFYVVQLVSVFVGQHDATVSQLSVI--LGYANSCANPILYGFLSDNFK 273
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
54-358 3.13e-09

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 57.90  E-value: 3.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  54 MVTLNAIALLANSGVLTVVVKV-----PHLRKFSLVCHLCIVDLLcaallmplgiVCGSPFFAGIVFSVLE--------- 119
Cdd:cd15198    4 LIFLGVILVAGVAGNTTVLCWLcggrrRKSRMNFLLLQLALADLL----------VIGGTALSQIIWELLGdrwmagdva 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRyeakmTPWLSAAVMGFVWVASTLLGL--ATVFGWPSYGSRSSIAA 197
Cdd:cd15198   74 CRLLKLLQASARGASANLVVLLALDRHQAIRAPLG-----QPLRAWKLAALGWLLALLLALpqAYVFRVDFPDDPASAWP 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 THCSLHWSHSG----HRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPipswtMATAHPKRRSDSVNSQTTi 273
Cdd:cd15198  149 GHTLCRGIFAPlprwHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPG-----AKKPWKKPSKSHLRATAP- 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 274 ittstsvrrNQVPRRKRRTLvggkaALTLAIIVgQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFF 353
Cdd:cd15198  223 ---------SALPRAKVKTL-----KMTLVIAL-LFVGCSLPYFIAELAAAFGSGDWEPEKVAAALGVMAVANSATNPFV 287

                 ....*
gi 966710671 354 YGLLN 358
Cdd:cd15198  288 FLFFN 292
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
115-365 3.66e-09

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 57.44  E-value: 3.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 115 FSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYgSRSS 194
Cdd:cd15192   68 FGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVF-FIEN 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 195 IAATHCSLHW--SHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKvahtaarergpipswTMATAHPKRRSDSVNSQtt 272
Cdd:cd15192  147 TNITVCAFHYpsQNSTLLVGLGLMKNLLGFLIPFLIILTCYTLIGK---------------ALKKAYEIQRNKPRNDE-- 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 273 iittstsvrrnqvprrkrrtlvggkAALTLAIIVGQFLLCWLPYFAFH-------LHLSLGFSHSTSEEAEGPVT-WLAY 344
Cdd:cd15192  210 -------------------------IFKMIMAVVLFFFFCWIPHQIFTfldvliqLKVIQDCHIADIVDTAMPFTiCIAY 264
                        250       260
                 ....*....|....*....|.
gi 966710671 345 STFAVNPFFYGLLNRQIREEL 365
Cdd:cd15192  265 FNSCLNPILYGFVGKNFRKKF 285
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
56-365 3.92e-09

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 57.44  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  56 TLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISA 133
Cdd:cd15397    9 LVMAVGLLGNICLICVIARQKEKTNVTniLIANLSFSDILVCLVCLPFTVV--YTLMDYWIFGEVLCKMTPFIQCMSVTV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPM--------RYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAThCSLHWS 205
Cdd:cd15397   87 SILSLVLIALERHQLIINPTgwkpsvsqAYLAVVVIWMLACFISLPFLAFHILTDEPYKNLSHFFAPLADKAV-CTESWP 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 206 HSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKvahtaaRERgpipswtmatahpkRRSDSVNsqttiittstsvRRNQV 285
Cdd:cd15397  166 SEHHKLAYTTWLLLFQYCLPLLFILVCYLRIYL------RLR--------------RRKDMLE------------RRGEY 213
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 286 PRRKRRTlvgGKAALTLAIIVGQFLLCWLPYFAF------------HLHLSLGFS--HSTseeaegpvtwlAYSTFAVNP 351
Cdd:cd15397  214 NRRAGHS---KRINVMLVSLVAAFALCWLPLNVFnaiadwnheaipHCQHNLIFSlcHLA-----------AMASTCVNP 279
                        330
                 ....*....|....
gi 966710671 352 FFYGLLNRQIREEL 365
Cdd:cd15397  280 IIYGFLNSNFKKEV 293
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
59-316 4.87e-09

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 57.05  E-value: 4.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKF--SLVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIF 136
Cdd:cd14977   12 AVGIIGNLMVLCIVCTNYYMRSVpnILIASLALGDLLLLLLCVPLNAY--NLLTKDWLFGDVMCKLVPFIQVTSLGVTVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 137 TVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWP--SYGSRSSIAATHCSLHWSHSG---HRR 211
Cdd:cd14977   90 SLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTvaRESSLDNSSLTVCIMKPSTPFaetYPK 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 212 VFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpKRRSDsvnsqttiittstsvRRNQVPRRKRR 291
Cdd:cd14977  170 ARSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAKEY-------------TRGTK---------------KHMKQRRQLAK 221
                        250       260
                 ....*....|....*....|....*
gi 966710671 292 TLVGgkaaltlaiIVGQFLLCWLPY 316
Cdd:cd14977  222 TVLC---------LVLVFAFCWLPE 237
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
60-362 5.71e-09

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 57.20  E-value: 5.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15980   13 LCMMGNGVVCFIVLRSKHMRTVTnlFILNLAISDLLVGIFCMPTTLL--DNIIAGWPFGSTVCKMSGMVQGISVSASVFT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPmrYEAKMTPWLSAAVMGFVWVastllgLATVFGWPS-----------------YGSRSSiAATHC 200
Cdd:cd15980   91 LVAIAVDRFRCIVYP--FKQKLTISTAVVIIVIIWV------LAIAIMCPSavmlhvqeeknyrvvlgSQNKTS-PVYWC 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGnvykvahtaareRGPIPSWTMATAHPKRRSDSvnsqttiittstsv 280
Cdd:cd15980  162 REDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYA------------RIGITLFKTAMPHTGKHNQE-------------- 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 281 RRNQVPRRKRRTLvggKAALTLAIIvgqFLLCWLPYFAfhLHLSLGFSHSTSEEAE------GPVT-WLAYSTFAVNPFF 353
Cdd:cd15980  216 QRHVVSRKKQKVI---KMLLIVALL---FILSWLPLWT--LMMLSDYANLSPNQLQiiniyiYPFAhWLAFFNSSVNPII 287

                 ....*....
gi 966710671 354 YGLLNRQIR 362
Cdd:cd15980  288 YGFFNENFR 296
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
52-365 6.28e-09

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 56.71  E-value: 6.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLLCAALLMPLGIVCGSPFF--AGIVFSVLECRLYIFLn 127
Cdd:cd15102    5 VVFVAICCFIVLENLLVLIAIWRHMkfHRPMYYFLGNLALSDLLAGAAYLANILLSGARTLrlSPAQWFLREGSMFVAL- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 afliSASIFTVTVISIERYFYIVHPMRYEAKMTPWLsAAVMGFVWVASTLLGLATVFGWPSYGSRSSiAATHCSLHWSHS 207
Cdd:cd15102   84 ----SASVFSLLAIAIERHLTMAKMKPYGASKTSRV-LLLIGACWLISLLLGGLPILGWNCLGALDA-CSTVLPLYSKHY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 208 ghrrvfaILFCTLCFCVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpkrrsdsvnsqttiittstsvRRNQVPR 287
Cdd:cd15102  158 -------VLFCVTIFAGILAAIVALYARIYCLVRASG------------------------------------RKATRAS 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 288 RKRRTLVGGKaalTLAIIVGQFLLCWLPYFAFhLHLSLGFSHSTSEEAEGPVTWLAYSTF--AVNPFFYGLLNRQIREEL 365
Cdd:cd15102  195 ASPRSLALLK---TVLIVLLVFIACWGPLFIL-LLLDVACPVKTCPILYKADWFLALAVLnsALNPIIYTLRSRELRRAV 270
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
52-362 7.71e-09

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 56.33  E-value: 7.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFslvCHLCIVDLLCAALLMPLGIVCgSPFFAGIVFSVLECRLYIFLNAFL- 130
Cdd:cd15349    5 VLFICISVLIILENLLVLLAILRRVRLRRW---VYICLANIALSDLLTGTSYLV-NICLSGERTFRLTPALWFLREGLLf 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 --ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWP---SYGSRSSIAATHCSLHws 205
Cdd:cd15349   81 taLAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWNclcDFRSCSSLLPLYSKSY-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 206 hsghrrvfaILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtMATAHPKRRSdsvnsqttiittstsvrrnqv 285
Cdd:cd15349  159 ---------ILFCLVIFFIILLTIIGLYFAIYCLVRASGQR--------VISARSRRRS--------------------- 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 286 prrkRRTLVggkaalTLAIIVGQFLLCWLPYFAFhLHLSLGFSHSTSEEAEGP--VTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15349  201 ----LRLLK------TVLMILGAFMVCWGPLFIL-LLVDFFCSSRSCKPLFGMewVLALAVLNSAINPLIYSFRSLEVR 268
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
48-365 1.06e-08

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 55.97  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  48 MSGLVVMVtLNAIALLANSGVLTVVVKVPHLRKFS----LVCHLCIVDLlcaallmplGIVCGSPFFA-------GIVFS 116
Cdd:cd14976    2 LVSVVYMV-VFTVGLLGNLLVLYLLKSNKKLRQQSesnkFVFNLALTDL---------IFVLTLPFWAveyaldfVWPFG 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 117 VLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLAT-VFGWPSYGsrsSI 195
Cdd:cd14976   72 TAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEaIFSTDTWS---SV 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 196 AATHCSLHW--SHSGHRR-----VFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGpipswtmatahpkrrsdsvn 268
Cdd:cd14976  149 NHTLCLLRFpkNSSVTRWynwlgMYQLQKVVLGFFLPLGIITLSY---LLLLRFLQRKRG-------------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 269 sqttiittstsvrrnqvpRRKRRTlvgGKAALTLAIIVGQFLLCWLPYFAFHLHLSLG------FSHS--TSEEAEGPVT 340
Cdd:cd14976  206 ------------------GSKRRK---SRVTKSVFIVVLSFFICWLPNQALSLWSALIkfddvpFSDAffAFQTYAFPVA 264
                        330       340
                 ....*....|....*....|....*.
gi 966710671 341 -WLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd14976  265 iCLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
60-362 1.52e-08

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 55.63  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPhlrKFSLVCHLCIVDLLCAALLMPLGIvcgsPFFAGIV------FSVLECRLYIFLNAFLISA 133
Cdd:cd15973   13 VGLIGNSMVIFVILRYA---KMKTATNIYILNLAIADELFMLSV----PFLAASAalqhwpFGSAMCRTVLSVDGINMFT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAthCSLHWSHSGHRRVF 213
Cdd:cd15973   86 SVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVA--CNLIWPHPAWSAAF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 214 AILFCTLCFCVPAAII----IAVYGNVYKVAHTAARERgpipswtmatahpKRRSDsvnsqttiittstsvrrnqvprrk 289
Cdd:cd15973  164 VIYTFLLGFLLPVLAIglcyILIIGKMRAVALKAGWQQ-------------RRKSE------------------------ 206
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 290 rrtlvgGKAALTLAIIVGQFLLCWLPYFAFHL-HLSLGFSHSTSEEAEgpvTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15973  207 ------KKITRMVLMVVTVFVICWMPFYVVQLlNLFLPRLDATVNHAS---LILSYANSCANPILYGFLSDNFR 271
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
60-365 3.37e-08

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 54.44  E-value: 3.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKF--SLVCHLCIVDLLCAALLMPLGIVcgsPFFAG-IVFSVLECRLYIFLNAFLISASIF 136
Cdd:cd15979   13 LSVFGNMLIIVVLGLNKRLRTVtnSFLLSLALSDLMLAVFCMPFTLI---PNLMGtFIFGEVICKAVAYLMGVSVSVSTF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 137 TVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLA-TVFGWPSYGSRSSIAATH-CSLHWSHSGHRRVFA 214
Cdd:cd15979   90 SLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPyPVYSVTVPVPVGDRPRGHqCRHAWPSAQVRQAWY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 215 ILFCTLCFCVPAAIIIAVYGnvykvahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrnQVPRRKRRTLV 294
Cdd:cd15979  170 VLLLLILFFIPGVVMIVAYG-------------------------------------------------LISRELYRGLL 200
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966710671 295 GGKAAL-TLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW---LAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15979  201 AKKRVIrMLVVIVAMFFLCWLPIFSANTWRAFDPLSAHRALSGAPISFihlLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
60-364 3.48e-08

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 54.52  E-value: 3.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAalLMPLGIVCGSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15402   13 VDILGNLLVILSVYRNKKLRNAGniFVVSLAVADLVVA--IYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF-GWPSYGSRssiaATHCSLHWSHSGHRRVFAIL 216
Cdd:cd15402   91 ITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFvGSLQYDPR----IYSCTFAQSVSSAYTIAVVF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 217 FctlCFCVPAAIIIAVYGNVykvahtaarergpipsWTMATAHPKRrsdsvnsqttiittstsVRRNQVPRRKRRTLvgg 296
Cdd:cd15402  167 F---HFILPIIIVTFCYLRI----------------WILVIQVRRR-----------------VKPDNKPKLKPHDF--- 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 297 KAALTLAIIVGQFLLCWLPyFAFhlhlsLGFSHSTSEEAEGPVT--WL-------AYSTFAVNPFFYGLLNRQIREE 364
Cdd:cd15402  208 RNFVTMFVVFVLFAVCWAP-LNF-----IGLAVAVDPETIVPRIpeWLfvasyymAYFNSCLNAIIYGLLNQNFRRE 278
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
51-189 3.56e-08

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 54.95  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLGIVC---GSPFfagiVFSVLECRLYIF 125
Cdd:cd15217    4 LVLLGLIICVSLAGNLIVSLLVLKDRALHKapYYFLLDLCLADTIRSAVCFPFVLVSirnGSAW----TYSVLSCKIVAF 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSY 189
Cdd:cd15217   80 MAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTY 143
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
59-358 4.01e-08

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 54.08  E-value: 4.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPhlrKFSLVCHLCIVDLLCAALLMPLGIvcgsPFFAGIV------FSVLECRLYIFLNAFLIS 132
Cdd:cd15971   12 IIGLCGNTLVIYVILRYA---KMKTVTNIYILNLAIADELFMLGL----PFLAIQValvhwpFGKAICRVVMTVDGINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF--GWPSYGSRSSiaathCSLHW--SHSG 208
Cdd:cd15971   85 TSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIyaGVQTKHGRSS-----CTIIWpgESSA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLCFCVPAAIIIAVY-GNVYKVAHTAARergpipswtmatahpkrrsdsVNSQttiittstsvrrnqvpR 287
Cdd:cd15971  160 WYTGFIIYTFILGFFVPLTIICLCYlFIIIKVKSSGIR---------------------VGSS----------------K 202
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 288 RKRRTlvgGKAALTLAIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGP---VTWLAYSTFAVNPFFYGLLN 358
Cdd:cd15971  203 RKKSE---KKVTRMVSIVVAVFVFCWLPFYIFNV-SSVSVSISPTPGLKGMfdfVVVLSYANSCANPILYAFLS 272
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
61-365 4.55e-08

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 54.05  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  61 ALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFTV 138
Cdd:cd15202   14 SLFGNVLVCWIIFKNQRMRTVTnyFIVNLAVADIMITLFNTPFTFV--RAVNNTWIFGLFMCHFSNFAQYCSVHVSAYTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 139 TVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGL--ATVFGWPSYGSRSSIAATHCSLHW-SHSG-HRRVFA 214
Cdd:cd15202   92 TAIAVDRYQAIMHPLK--PRISKTKAKFIIAVIWTLALAFALphAICSKLETFKYSEDIVRSLCLEDWpERADlFWKYYD 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 215 ILFCTLCFCVPAAIIIAVYGnvyKVAHTAARERGPIPSWTmatahpkrrsdsvnsqttiittstsvRRNQVPRRKRRTLV 294
Cdd:cd15202  170 LALFILQYFLPLLVISFAYA---RVGIKLWASNMPGDATT--------------------------ERYFALRRKKKKVI 220
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966710671 295 GgkaalTLAIIVGQFLLCWLPYFAFHLHLSL--GFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15202  221 K-----MLMVVVVLFALCWLPFNIYVLLLSSkpDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
51-362 5.03e-08

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 53.97  E-value: 5.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd15000    3 SSMFLPVVLFGIFGNFVLLYILASNRSLRTPTnlLIGNMALADLLTLLVCPWMFLV--HDFFQNYVLGSVGCKLEGFLEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMryEAKMTPWLSAAVMGFVWVASTLLGLATVFgWPSYGSR--SSIAATHCS----- 201
Cdd:cd15000   81 SLLLASVLALCAVSYDRLTAIVLPS--EARLTKRGAKIVIVITWIVGLLLALPLAI-YRSYRERqwKNFLETYCAentqv 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 202 --LHWShsghrrvfaiLFCTLCFCVPAAIIIAVYGNV-YKVAHTAARergpipswtmatahpkrrsdsvnsqttiittst 278
Cdd:cd15000  158 lpIYWH----------VIITVLVWLPLGIMLICYSAIfWKLDKYERR--------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 279 sVRRNQVPRRKRRTlvgGKAALTLAIIVGQFLLCWLPYFAF-HLHLSLGFSHSTSEEAEGPVT--WLAYSTF-----AVN 350
Cdd:cd15000  195 -VLRREHPSVVRYK---KKAAKTLFIVLITFVVCRIPFTALiFYRYKLVPNDNTQNSVSGSFHilWFASKYLmflnaAVN 270
                        330
                 ....*....|..
gi 966710671 351 PFFYGLLNRQIR 362
Cdd:cd15000  271 PLIYGFTNENFR 282
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
87-363 5.50e-08

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 54.00  E-value: 5.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIV---CGSPFfagiVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWL 163
Cdd:cd15358   42 LAVSDLLVLLLGMPLELYemwSNYPF----LLGAGGCYFKTLLFETVCFASILNVTALSVERYIAVVHPLKAKYVVTRTH 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 164 SAAVMGFVWVASTLLGLAT-----VFGWPSYGSRSSIAATHCSL---HWSHSGHRRVFAILFctlcFCVPAAIIIAVYgn 235
Cdd:cd15358  118 AKRVIGAVWVVSILCSIPNtslhgIFQLTVPCRGPVPDSATCMLvkpRWMYNLIIQITTLLF----FFLPMGTISVLY-- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 236 vYKVAHTAARERgpipswTMATAHPKRRSDSVNSQTtiittstsvRRNQVPRRKRRtlvggKAALTLAIIVGQFLLCWLP 315
Cdd:cd15358  192 -LLIGLQLKREK------MLLVLEAKGSKAGDSYQH---------RRIQQEKRRRR-----QVTKMLFVLVVVFGICWAP 250
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 316 YFAFHL------------HLSLGFSHSTSeeaegpvTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15358  251 FHTDRLmwsfisqwtgelHLAFQYVHIIS-------GVFFYLSSAANPVLYNLMSTRFRE 303
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
115-362 6.14e-08

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 53.80  E-value: 6.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 115 FSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL-ATVFGwpSYGSRS 193
Cdd:cd15091   67 FGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGIsAIVLG--GTKVRE 144
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 194 SIAATHCSLHWSHsgHRRVFAILFCTLC-----FCVPAAIIIAVYgnvykvahtaarergpipswTMATAHPKrrsdsvn 268
Cdd:cd15091  145 DVDSTECSLQFPD--DDYSWWDTFMKICvfifaFVIPVLIIIVCY--------------------TLMILRLK------- 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 269 sqttiittstSVRRNQVPRRKRRTLvgGKAALTLAIIVGQFLLCWLPYFAFHLHLSLG-FSHSTSE-EAEGPVTWLAYST 346
Cdd:cd15091  196 ----------SVRLLSGSREKDRNL--RRITRLVLVVVAVFVVCWTPIHIFILVEALGsVSHSTAAvSSYYFCIALGYTN 263
                        250
                 ....*....|....*.
gi 966710671 347 FAVNPFFYGLLNRQIR 362
Cdd:cd15091  264 SSLNPILYAFLDENFK 279
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
59-264 7.01e-08

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 53.48  E-value: 7.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKvpHLRKFS----LVCHLCIVDLLCAALLmPLGIVCgspFFAGI--VFSVLECRLYIFLNAFLIS 132
Cdd:cd15168   12 LVGLLLNSVVLYRFIF--HLKPWNssaiYMFNLAVSDLLYLLSL-PFLIYY---YANGDhwIFGDFMCKLVRFLFYFNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSgHRRV 212
Cdd:cd15168   86 GSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEELN-DYVI 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966710671 213 FAILFCTLCFCVPAAIIIAVYGnvyKVAHTAARERGPIPswtmaTAHPKRRS 264
Cdd:cd15168  165 YSMVLTGLGFLLPLLIILACYG---LIVRALIRKLGEGV-----TSALRRKS 208
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
55-365 8.01e-08

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 53.29  E-value: 8.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  55 VTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLgivCGSPFF------AGIVFSVLECRLYIFLNA 128
Cdd:cd15078    5 LLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSL---LGVTFTfmscvrGRWVFDVAGCVWDGFSNS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHpmryeAKMT--PWLSAAVMgFVWVASTLLGLATVFGWPSYgsrssIAATH---CSLH 203
Cdd:cd15078   82 LFGIVSIMTLTVLAYERYIRVVH-----AKVVnfSWSWRAIT-YIWLYSLAWTGAPLLGWNRY-----TLEVHglgCSFD 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 W-SHSGHRRVFAILFCTLCFCVPAAIIIAVYGNV-YKVAHTAARErgpipswtmatahpkrrsDSVNSQTTIITTSTSvr 281
Cdd:cd15078  151 WkSKDPNDTSFVLLFFLGCLVVPLGIMAYCYGHIlYEIRMLRSVE------------------DLQTFQVIKILKYEK-- 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 282 rnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQI 361
Cdd:cd15078  211 ---------------KVAKMCLLMISTFLICWMPYAVVSLLVTSGYSKLVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKF 275

                 ....
gi 966710671 362 REEL 365
Cdd:cd15078  276 RQCL 279
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
52-363 8.55e-08

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 53.70  E-value: 8.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCH-----LCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLECRLYIFL 126
Cdd:cd15355    5 AIYLALFVVGTVGNSITLYTLARKKSLQHLQSTVHyhlasLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGYYFL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpSYGSRSSIAATH----CSL 202
Cdd:cd15355   85 RDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLF---TMGEQNRSGTHPggliCTP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHSGHRRVFAIlFCTLCFCVPaAIIIAVYGNVykVAHTAARergpipswTMATAHPKRRSDSVNSQTTIITTSTSVRR 282
Cdd:cd15355  162 IVDTSTLKVVIQV-NAFLSFLFP-MLVISVLNTL--IANQLTV--------MVNQAEQENQVCTIGGQRTVLSVSMEPGR 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 NQVPRRkrrtlvggkAALTLAIIVGQFLLCWLPYFAFHLHlslgFSHSTSEEAEGPV-----------TWLAYSTFAVNP 351
Cdd:cd15355  230 VQSLRH---------GVLVLRAVVIAFVVCWLPYHVRRLM----FCYVSDEQWTTFLydfyhyfymltNVLFYVSSAINP 296
                        330
                 ....*....|..
gi 966710671 352 FFYGLLNRQIRE 363
Cdd:cd15355  297 ILYNLVSANFRQ 308
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
52-365 1.33e-07

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 52.72  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAallmpLGIVCGSpFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15961    5 IVLCTSGTLISCENAIVVLIIFQNPSLRApmFLLIGSLALADLLAG-----IGLILNF-IFAYLLQSEAAKLVTVGLIVA 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaathCSLHWSHSgh 209
Cdd:cd15961   79 SFSASVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLADEST-----CSVVRPLT-- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 RRVFAILfcTLCFCVPAAIIIAVYGNVYKVAHTAARERGpIPSWTMATAHpkrrsdsvnsqttiittstsvrrnQVPRRk 289
Cdd:cd15961  152 KNNAAIL--SVSFLLMFALMLQLYIQICKIVMRHAHQIA-LQHHFLATSH------------------------YVTTR- 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 290 rrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAystfAVNPFFYGLLNRQIREEL 365
Cdd:cd15961  204 -------KGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNS----IINPVIYAFRNQEIQKAL 268
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
52-364 1.36e-07

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 52.61  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15401    5 GVLIFTIVVDVLGNLLVILSVLRNKKLRNAGniFVVSLSVADLVVAVYPYPLILL--AIFHNGWTLGNIHCQISGFLMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF-GWPSYGSRssiaATHCSLHWSHSG 208
Cdd:cd15401   83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFvGSLQYDPR----IYSCTFAQTVSS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HrrvFAILFCTLCFCVPAAIIIAVYGNVykvahtaarergpipsWTMATAHPKR-RSDSVNSqttiittstsVRRNQVpr 287
Cdd:cd15401  159 S---YTITVVVVHFIVPLSIVTFCYLRI----------------WVLVIQVKHRvRQDSKQK----------LKANDI-- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 288 rkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEgpvtWL-------AYSTFAVNPFFYGLLNRQ 360
Cdd:cd15401  208 ---------RNFLTMFVVFVLFAVCWGPLNFIGLAVAINPLKVAPKIPE----WLfvlsyfmAYFNSCLNAVIYGVLNQN 274

                 ....
gi 966710671 361 IREE 364
Cdd:cd15401  275 FRKE 278
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
53-364 1.69e-07

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 52.55  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAalLMPLGIVCGSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15400    6 VLIFTTVVDILGNLLVIISVFRNRKLRNSGnvFVVSLALADLVVA--LYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF-GWPSYGSRssiaATHCSLHWSHSGH 209
Cdd:cd15400   84 VIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFvGSLEYDPR----IYSCTFVQTASSS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 210 rrvFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARErgpipswtmatahpkrrsdsvnsqttiittstsVRRNQVPRRK 289
Cdd:cd15400  160 ---YTIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRK---------------------------------VKSESKPRLK 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 290 RRTLvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVT---WLAYSTFAVNPFFYGLLNRQIREE 364
Cdd:cd15400  204 PSDF---RNFLTMFVVFVIFAICWAPLNLIGLAVAINPQEMAPKVPEWLFVvsyFMAYFNSCLNAIIYGLLNQNFRKE 278
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
55-365 1.70e-07

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 52.51  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  55 VTLNAIALLANSG---VLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15395    5 LAYSAVIILGVSGnlaLIIIILKQKEMHNVTniLIVNLSFSDLLMTIMCLPFTFV--YTLMDHWVFGEAMCKLNSMVQCI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEakmtPWLSAAVMGF--VWVASTLLGLATV---------FGWPSYGSRSSIAAT 198
Cdd:cd15395   83 SITVSIFSLVLIAIERHQLIINPRGWR----PNNRHAYVGIavIWVLAVLTSLPFLifqvltdepFKNVNVSLDAYKGKY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 HCSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYkvahtaarergpipswtmatAHPKRRSDSVNSqttiittst 278
Cdd:cd15395  159 VCLDQFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIY--------------------IRLKRRNNMMDK--------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 279 sVRRNqvprrKRRTLVGGKAALTLAIIVGQFLLCWLPYFAFhlHLSLGFSHSTSEEAEGPVTWL-----AYSTFAVNPFF 353
Cdd:cd15395  210 -MRDN-----KYRSSETKRINIMLISIVVAFAVCWLPLNIF--NAVFDWNHEAIATCNHNLLFLichltAMISTCVNPIF 281
                        330
                 ....*....|..
gi 966710671 354 YGLLNRQIREEL 365
Cdd:cd15395  282 YGFLNKNFQRDL 293
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
48-356 1.77e-07

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 52.44  E-value: 1.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  48 MSGLVVMVTLNAIALLANsgvLTVVVKVPHLRK-----FSLVCHLCIVDLLCAALLMPLGIVCGS--PFFAGivfsVLEC 120
Cdd:cd15384    1 LLKIVVLAVMFVISFIGN---LLTIIQIYRLRRsrrtiYSLLLHLAIADLLVTFFCIPSEAIWAYtvAWLAG----NTMC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 121 RLYIFLNAFLISASIFTVTVISIERYFYIVHPMRyEAKMtPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHC 200
Cdd:cd15384   74 KLVKYLQVFGLYLSTYITVLISLDRCVAILYPMK-RNQA-PERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHQC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSHSG--HRRVFAILFCTLCFCVPAAIIIAVYGNVYkvaHTAARergpipSWTMATAHPkrrSDSVNSQTtiittst 278
Cdd:cd15384  152 VTYGFYTAewQEQLYNMLSLVFMFPIPLVIMVTCYVLIF---ITLSK------SSRDFQGLE---IYTRNRGP------- 212
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 279 sVRRNQVPRRKRRTLvggkaaLTLAIIVGQFLLCWLPYFAFHLhLSLGFSHST-SEEAEGPVTWLAYSTFAVNPFFYGL 356
Cdd:cd15384  213 -NRQRLFHKAKVKSL------RMSAVIVTAFILCWTPYYVIMI-WFLFFNPYPlNDILFDVIFFFGMSNSCVNPLIYGA 283
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
131-362 1.95e-07

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 52.19  E-value: 1.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVHpMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiAATHCSLHWSHSghr 210
Cdd:cd15346   83 LSASVFSLLAIAIERYITMLK-MKLHNGSNSFRSFLLISACWVISLILGGLPIMGWNCISALSS-CSTVLPLYHKHY--- 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 211 rvfaILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSWTMATahpkrrsdsvnsqttiittstsvrrnqvpRRKR 290
Cdd:cd15346  158 ----ILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKAS-----------------------------RSSE 204
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966710671 291 RTLVGGKaalTLAIIVGQFLLCWLPYFAFhLHLSLGFSHSTSE---EAEGPVTwLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15346  205 KSMALLK---TVIIVLSVFIACWAPLFIL-LLLDVGCKVKTCSilfKAEYFLV-LAVLNSATNPIIYTLTNKEMR 274
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
51-234 2.49e-07

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 51.89  E-value: 2.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVC-----HLCIVDLLCAALLmplgivcgsPFFA-----GIVFSVLEC 120
Cdd:cd15178    1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTdvyllHLAIADLLFALTL---------PFWAvsvvkGWIFGTFMC 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 121 RLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWlSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiAATHC 200
Cdd:cd15178   72 KLVSLLQEANFYSGILLLACISVDRYLAIVHATRALTQKRHL-VKFVCAGVWLLSLLLSLPALLNRDAFKPPNS-GRTVC 149
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 966710671 201 SLHW---SHSGHRRVFAILFCTLCFCVPAAIIIAVYG 234
Cdd:cd15178  150 YENLgneSADKWRVVLRILRHTLGFLLPLVVMLFCYG 186
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
59-365 2.62e-07

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 51.95  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGI---VCGSpffagIVFSVLECRLYIFLNAFLISA 133
Cdd:cd15389   12 VISLFGNSLVCHVIFKNKRMHTATnlFIVNLAVSDILITLLNTPFTLvrfVNST-----WVFGKIMCHLSRFAQYCSVYV 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGHRRVF 213
Cdd:cd15389   87 STLTLTAIALDRHRVILHPLK--PRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSFPEPSDLF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 214 A---ILFCTLCFCV-PAAIIIAVYGnvyKVAHTAAReRGPIPSWTMATAHPKRRSdsvnsqttiittstsvrrnqvprrK 289
Cdd:cd15389  165 WkylDLATFILQYVlPLLIIGVAYT---RVAKKLWL-RNAIGDVTTEQYVAQRRK------------------------K 216
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 290 RRTLVggkaalTLAIIVGQFLLCWLPYFAFHLHLSL-GFSHSTSeeAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15389  217 KKTIK------MLMLVVLLFAICWLPLNCYHVLLSShPIRSNSA--LFFAFHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
52-365 2.97e-07

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 51.82  E-value: 2.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVF--------SVLeCR 121
Cdd:cd15137    5 VFIWVVGIIALLGNLFVLIWRLKYKEENKvhSFLIKNLAIADFLMGVYLLIIASV--DLYYRGVYIkhdeewrsSWL-CT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 122 LYIFLNAFLISASIFTVTVISIERYFYIVHPMRYeAKMTPWLSAAVMGFVWVASTLLGLATVFGWPS---YGSRSSIaat 198
Cdd:cd15137   82 FAGFLATLSSEVSVLILTLITLDRFICIVFPFSG-RRLGLRRAIIVLACIWLIGLLLAVLPLLPWDYfgnFYGRSGV--- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 hC-SLH--------WSHSghrrVFAILFCTLCFCVpaaIIIAVYGNVYKVAHTAARergpipswtmATAHPKRRSDSVns 269
Cdd:cd15137  158 -ClPLHitderpagWEYS----VFVFLGLNFLAFV---FILLSYIAMFISIRRTRK----------AAASRKSKRDMA-- 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 270 qttiittstsvrrnqVPRRkrrtlvggkaaltLAIIVGQFLLCWLPYFAFHLhLSLgFSHSTSEEAEGpvtWLAysTF-- 347
Cdd:cd15137  218 ---------------VAKR-------------FFLIVLTDFLCWIPIIVIGI-LAL-SGVPIPGEVYA---WVA--VFvl 262
                        330       340
                 ....*....|....*....|..
gi 966710671 348 ----AVNPFFYGLLNRQIREEL 365
Cdd:cd15137  263 pinsALNPILYTLSTPKFRKKL 284
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
83-239 3.28e-07

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 51.62  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  83 LVCHLCIVDLLcAALLMPLGIV---CGSPFFAGIVFsvleCRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKM 159
Cdd:cd15967   38 FVLNLGLADLL-YLLTLPFLVVyylKGRKWIFGQVF----CKITRFCFNLNLYGSIGFLTCISVYRYLAIVHPMRVMGRI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 160 TPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHC----------SLHWSHSGhrrvfailfctlcFCVPAAII 229
Cdd:cd15967  113 TTTHSVVISALVWLLVVIQSLPDLFFSKTNSNGTKCFDTTFndylesyltySLGWTVTG-------------FVIPLLII 179
                        170
                 ....*....|
gi 966710671 230 IAVYGNVYKV 239
Cdd:cd15967  180 LGCYGHVVVV 189
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
51-371 3.32e-07

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 51.36  E-value: 3.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIvcGSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd15295    4 LFLMSLLALVIVLGNALVIIAFVVDKNLRHRSnyFFLNLAISDFFVGAISIPLYI--PYTLTNRWDFGRGLCVFWLVIDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAV-MGFVWVASTLLGLATVFGWPSYgsrsSIAATHCSLHWSHS 207
Cdd:cd15295   82 LLCTASVYNIVLISYDRYQSVSNAVSYRNQQTATLRIVTqMVAVWVLAFLVHGPAILVSDSW----KTEDGECEPEFFSN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 208 GHrrvFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvpr 287
Cdd:cd15295  158 WY---ILAITSVLEFLVPVILVAYFNTQIYWSLWKRLRDR---------------------------------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 288 rkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVtWLAYSTFAVNPFFYGLLNRQIREELCK 367
Cdd:cd15295  195 ---------KLAKSLAIILGTFAICWAPYSLFTIIRAACEKHRGSPWYNFAF-WLQWFNSFINPFLYPLCHKRFRKAFLK 264

                 ....
gi 966710671 368 mLFC 371
Cdd:cd15295  265 -IFC 267
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
53-325 3.52e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 51.34  E-value: 3.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLcaallmplgiVCGSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSpmYFFICSLAVADML----------VSVSNALETIVIILLNNGYLVPRDSFE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 IS--------------ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpsygsrssia 196
Cdd:cd15103   76 QHidnvidsmicssllASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFII------------ 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 197 athcslhWSHSghrrVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPswtmatahpkrrsdsvnsqttiitt 276
Cdd:cd15103  144 -------YSDS----VPVIICLISMFFAMLVLMASLYVHMFLLARSHVKKIAALP------------------------- 187
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 966710671 277 stsvrrNQVPRRKRRTLvggKAALTLAIIVGQFLLCWLPYFafhLHLSL 325
Cdd:cd15103  188 ------GQRSTRQRANM---KGAVTLTILLGVFIFCWAPFF---LHLTL 224
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
55-362 4.26e-07

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 51.00  E-value: 4.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  55 VTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPLGIVCGSPFFAG---IVFSVLECRLYIFLNAFLI 131
Cdd:cd16004    5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYAShndWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 132 SASIFTVTVISIERYFYIVHPMRyeakmtPWLSA----AVMGFVWvastLLGLATVFGWPSYGS-RSSIAATHCSLHW-- 204
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPFK------PRLSAgstkVVIAGIW----LVALALAFPQCFYSTvTMDQGRTKCIVAWpg 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 -SHSGHRRVFAILFCTLCFCVPAAIIIAVYGnvyKVAHTAARERGPIPSWTMATAHpkrrsdsvnsqttiittstsvrrn 283
Cdd:cd16004  155 dSGGKHQLTYHLAVIVLIYLLPLAVMFVTYS---IIGITLWRSAVPGHQAHGAYHR------------------------ 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 QVPRRKrrtlvggKAALTLAIIVGQFLLCWLPYfafHLHLSLG------FSHSTSEEAEGPVTWLAYSTFAVNPFFYGLL 357
Cdd:cd16004  208 QLQAKK-------KFVKTMVVVVVTFAICWLPY---HLYFILGsfnediYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCL 277

                 ....*
gi 966710671 358 NRQIR 362
Cdd:cd16004  278 NQRFR 282
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
52-362 4.28e-07

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 51.34  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLcAALLMPLGIV---CGSPFfagiVFSVLECRLYIFL 126
Cdd:cd15928    5 AVCSVLMLVGASGNLLTVLVIGRSRDMRTTTnlYLSSLAVSDLL-IFLVLPLDLYrlwRYRPW----RFGDLLCRLMYFF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLG--LATVFGWPSYGSRSSIAATHCSLHW 204
Cdd:cd15928   80 SETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAgpALVLVGVEHIQGQQTPRGFECTVVN 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGHRRVFaILFCTLCFCVPAAIIIAVYGnvyKVAHTAARERGPipswtMATAHPKRRSDSvnsqttiittstsvRRNQ 284
Cdd:cd15928  160 VSSGLLSVM-LWVSTSFFFVPMVCLSLLYG---LIGRALWDRRQR-----SRTAGASRRDNN--------------HRQT 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 285 VPrrkrrtlvggkaalTLAIIVGQFLLCWLP-----YFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNR 359
Cdd:cd15928  217 VR--------------MLAVIVLAFVLCWLPfhvgrVIFNHSRASTKHLHYVSQYFNLVSFVLFYLSAAINPILYNLMSK 282

                 ...
gi 966710671 360 QIR 362
Cdd:cd15928  283 RYR 285
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
52-363 4.53e-07

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 50.96  E-value: 4.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPhlrKFSLVCHLCIVDLLCAALLMPLGIvcgsPFFAGIV------FSVLECRLYIF 125
Cdd:cd15974    5 VIYLLVCAIGLSGNTLVIYVVLRYA---KMKTVTNIYILNLAVADELFMLGL----PFLATQNaisywpFGSFLCRLVMT 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpsYGSRSSIAAThCSLHWS 205
Cdd:cd15974   78 VDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVII----FSDVQPDLNT-CNISWP 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 206 H--SGHRRVFAILFCTLCFCVPAAIIIAVY-GNVYKVAHTAARergpipswtmATAHPKRRSDsvnsqttiittstsvrr 282
Cdd:cd15974  153 EpvSVWSTAFIIYTAVLGFFGPLLVICLCYlLIVIKVKSSGLR----------VGSTKRRKSE----------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 nqvpRRKRRTLVggkaaltlaIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGP---VTWLAYSTFAVNPFFYGLLNR 359
Cdd:cd15974  206 ----RKVTRMVV---------IIVVVFVFCWLPFYMLNI-VNLIVILPEEPAFVGVyffVVVLSYANSCANPILYGFLSD 271

                 ....
gi 966710671 360 QIRE 363
Cdd:cd15974  272 NFKQ 275
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
51-239 4.57e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 50.93  E-value: 4.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLGIVCG----SPFFAGIVFSvleCRLYI 124
Cdd:cd15070    4 ISIEILIGLCAVVGNVLVIWVVKLNPSLRTttFYFIVSLALADIAVGVLVIPLAIVVSlgvtIHFYSCLFMS---CLLVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAflisaSIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHW 204
Cdd:cd15070   81 FTHA-----SIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQF 155
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 966710671 205 ShSGHRRVFAILFCTLCFC-VPAAIIIAVYGNVYKV 239
Cdd:cd15070  156 T-SVMRMDYMVYFSFFTWIlIPLVIMCALYVDIFYI 190
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
68-362 4.83e-07

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 50.98  E-value: 4.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  68 VLTVVVKVPHlRKFSLVCHLCIVDLLCAALLMplgIVCGSPF----FAGIVFSV--LECRLYIFLNAFLISASIFTVTVI 141
Cdd:cd15077   19 VLTIICTIKY-KKLRSHLNYILVNLAVANLIV---VCFGSTTafysFSQMYFVLgpLACKIEGFTATLGGMVSLWSLAVV 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 142 SIERYFYIVHPMryeAKMTPWLSAAVMG--FVWVASTLLGLATVFGWPSY---GSRSSiaathCSLHW---SHSGHRRVF 213
Cdd:cd15077   95 AFERFLVICKPL---GNFTFRGTHAIIGciATWVFGLAASLPPLFGWSRYipeGLQCS-----CGPDWyttNNKWNNESY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 214 AILFCTLCFCVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpKRRSDSVNSQttiittstsvrrnQVPRRKRRTL 293
Cdd:cd15077  167 VMFLFCFCFGVPLSIIVFSYGRLLLTLRAVA----------------KQQEQSASTQ-------------KAEREVTKMV 217
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 294 VggkaaltlaIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15077  218 V---------VMVLGFLVCWLPYASFALWVVTNRGEPFDLRLASIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
115-362 5.05e-07

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 51.02  E-value: 5.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 115 FSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSS 194
Cdd:cd16002   68 YGLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQ--PRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGR 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 195 IAathCSLHWSHSgHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHtaarergpIPSWtmATAHPKRRSDsvnsqttii 274
Cdd:cd16002  146 VV---CYVEWPEH-EERKYETVYHVCVTVLIYFLPLLVIGCAYTVVG--------ITLW--ASEIPGDSSD--------- 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 275 ttstsvrRNQVPRRKRRTLVGgkaalTLAIIVGQFLLCWLPYFAF----HLHLSLgFSHSTSEEAEGPVTWLAYSTFAVN 350
Cdd:cd16002  203 -------RYHEQVSAKRKVVK-----MMIVVVCTFAICWLPYHIYfllqYFHPEL-YEQKFIQQVYLAIMWLAMSSTMYN 269
                        250
                 ....*....|..
gi 966710671 351 PFFYGLLNRQIR 362
Cdd:cd16002  270 PIIYCCLNDRFR 281
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
60-362 6.23e-07

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 50.59  E-value: 6.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15399   13 LGVVGNSLVIYVVIKFKNMRTVTnfFIANLAVADLMVNTLCLPFTLV--YTLLDEWKFGAVLCHLVPYAQALAVHVSTVT 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMryEAKMTPWLSAAVMGFVWVASTLLG--LATVFGWPSYGSRSSIAATHCSLHW--SHSGHRRVF 213
Cdd:cd15399   91 LTVIALDRHRCIVYHL--ESKISKKISFLIIGLTWAASALLAspLAIFREYSVIEISPDFKIQACSEKWpnGTLNDGTIY 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 214 AILFCTLCFCVPAAIIIAVYgnvykvahtaarergpIPSWTMATAHpkrrsdsvnsqttiiTTSTSVRRNQVPRRKRRTL 293
Cdd:cd15399  169 SVSMLLIQYVLPLAIISYAY----------------IRIWTKLKNH---------------VSPGGGNDHYHQRRRKTTK 217
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966710671 294 VggkaaltLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAY----STFAvNPFFYGLLNRQIR 362
Cdd:cd15399  218 M-------LVCVVVVFAVSWLPFHAFQLASDIDSKVLDLKEYKLIYTIFHViamcSTFA-NPLLYGWMNNNYR 282
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
81-247 6.42e-07

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 50.35  E-value: 6.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  81 FSLVCHLCIVDLlCAALLMPLGIVCGSPFFAGIVfsvleCRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMT 160
Cdd:cd15297   40 FSLACADLIIGV-FSMNLYTLYTVIGYWPLGPVV-----CDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 161 PWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGhrrvfAILFCT--LCFCVPAAIIIAVYgnvYK 238
Cdd:cd15297  114 TKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPEGECYIQFFSNA-----AVTFGTaiAAFYLPVIIMTVLY---WQ 185

                 ....*....
gi 966710671 239 VAHTAARER 247
Cdd:cd15297  186 ISRASSREK 194
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
52-365 7.79e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 50.32  E-value: 7.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANsgVLTVVV-KVPHLRK--FSLVCHLCIVDLLCAALLMPLGIV---CGSPFFAGIVFSVLECRLYIF 125
Cdd:cd14978    5 YVLPVICIFGIIGN--ILNLVVlTRKSMRSstNVYLAALAVSDILVLLSALPLFLLpyiADYSSSFLSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGW-----PSYGSRSSIAATHC 200
Cdd:cd14978   83 LANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYevvecENCNNNSYYYVIPT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSHSGHRRVFAILFCTLCFCVPAAII----IAVYGNVYKvahtaarergpipSWTMATAHPKRRSDSVNSQttiitt 276
Cdd:cd14978  163 LLRQNETYLLKYYFWLYAIFVVLLPFILLlilnILLIRALRK-------------SKKRRRLLRRRRRLLSRSQ------ 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 277 stsvrrnqvpRRKRRTlvggkaALTLAIIVGQFLLCWLPYFAFHL--HLSLGFSHSTSEEAEGPVT-WLAYSTFAVNPFF 353
Cdd:cd14978  224 ----------RRERRT------TIMLIAVVIVFLICNLPAGILNIleAIFGESFLSPIYQLLGDISnLLVVLNSAVNFII 287
                        330
                 ....*....|..
gi 966710671 354 YGLLNRQIREEL 365
Cdd:cd14978  288 YCLFSSKFRRTF 299
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
51-362 1.02e-06

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 49.86  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLmPLGivcGSPFFAGI-VFSVLECRLYIFLN 127
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYVILRHTKMKTATniYIFNLALADTLVLLTL-PFQ---GTDIFLGFwPFGNALCKTVIAID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVastllgLATVFGWPSY---GSRSSIAATHCSLHW 204
Cdd:cd15092   80 YYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWA------LASVVGVPVMvmgSAQVEDEEIECLVEI 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGHR--RVFAILFCTLCFCVPAAIIIAVYGNVYKvahtaaRERGpipswtmatahpkrrsdsvnsqttiittstsVRR 282
Cdd:cd15092  154 PTPQDYwdPVFGICVFLFSFIIPVLIISVCYSLMIR------RLRG-------------------------------VRL 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 NQVPRRKRRTLvgGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGP--VTWLAYSTFAVNPFFYGLLNRQ 360
Cdd:cd15092  197 LSGSKEKDRNL--RRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSSETAVAILrfCTALGYVNSSLNPVLYAFLDEN 274

                 ..
gi 966710671 361 IR 362
Cdd:cd15092  275 FK 276
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
85-219 1.52e-06

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 49.80  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  85 CHLCIVDLLCAALLMPLGI--VCGSPFFAGIvfSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAkMTPW 162
Cdd:cd15135   43 VSLACSDLLVLLLGMPVELysAIWDPFATPS--GNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKA-LSGS 119
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 163 LSAAVMGFVWVASTLLGLATVFgwpSYGSRSSIAATHCSLHWSHSGHRRVFAILFCT 219
Cdd:cd15135  120 RVRLLICFVWLTSALVALPLLF---AMGTEDPLEAFPSYRGTRHHCQDQKSNLTICT 173
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
51-362 1.56e-06

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 49.61  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALL--MPLGIVCGSPFFAGIVfsvleCRLYIFL 126
Cdd:cd15090    4 MALYSIVCVVGLFGNFLVMYVIVRYTKMKTATniYIFNLALADALATSTLpfQSVNYLMGTWPFGNIL-----CKIVISI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAT----HCSL 202
Cdd:cd15090   79 DYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTltfsHPSW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHsghrrVFAILFCTLCFCVPAAIIIAVYGnvykvahtaarergpipswtmatahpkrrsdsvnsqtTIITTSTSVRR 282
Cdd:cd15090  159 YWEN-----LLKICVFIFAFIMPVLIITVCYG-------------------------------------LMILRLKSVRM 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 283 NQVPRRKRRTLvgGKAALTLAIIVGQFLLCWLPyfaFHLHLSLGFSHSTSEEAEGPVTW-----LAYSTFAVNPFFYGLL 357
Cdd:cd15090  197 LSGSKEKDRNL--RRITRMVLVVVAVFIVCWTP---IHIYVIIKALVTIPETTFQTVSWhfciaLGYTNSCLNPVLYAFL 271

                 ....*
gi 966710671 358 NRQIR 362
Cdd:cd15090  272 DENFK 276
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-184 1.86e-06

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 49.17  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFSLVCH-----LCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLECRLYIFLNAFLISA 133
Cdd:cd15130   12 VVGTVGNSVTLFTLARKKSLQSLQSTVRyhlgsLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYA 91
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF 184
Cdd:cd15130   92 TALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLF 142
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
133-362 2.06e-06

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 49.14  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHP---MRYEAKmtpwLSAAVMGFVWVASTLLGLATVFGWPSY---GSRSSIAATHCSLHwSH 206
Cdd:cd15081   98 TGLWSLTIISWERWVVVCKPfgnIKFDGK----LAIVGIIFSWVWSAVWCAPPIFGWSRYwphGLKTSCGPDVFSGS-SD 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SGHRRVFAILFCTLCFcVPAAIIIAVYGNVYKVAHTAArergpipswtmatahpKRRSDSVNSQttiittstsvrrnQVP 286
Cdd:cd15081  173 PGVQSYMIVLMITCCI-IPLAIIILCYLQVWLAIRAVA----------------QQQKESESTQ-------------KAE 222
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 287 RRKRRTLVggkaaltlaIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15081  223 KEVSRMVV---------VMIFAYCFCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
52-362 2.13e-06

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 49.02  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIvcgsPFF--AGIVFSVLECRLYIFLN 127
Cdd:cd15296    5 VLMALLVVATVLGNALVILAFVVDSSLRTQGnfFFLNLAISDFLVGGFCIPLYI----PYVltGRWKFGRGLCKLWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAV-MGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSH 206
Cdd:cd15296   81 YLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVLkMVLVWVLAFLLYGPAIISWEYIAGGSIIPEGECYAEFFY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 207 SGHrrvFAILFCTLCFCVPaaIIIAVYGNVykvahtaarergpipswtmatahpkrrSDSVNSQTtiittstsvRRNQVP 286
Cdd:cd15296  161 NWY---FLMTASTLEFFTP--FISVTYFNL---------------------------SIYLNIQK---------RRFRLS 199
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 287 RRKrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15296  200 RDK-------KVAKSLAIIVCVFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFR 268
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
69-362 2.69e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 48.68  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  69 LTVVVKVPHlRKFSLVCHLCIVDLLCAALLMPLG---IVCGSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIER 145
Cdd:cd15080   20 LTLYVTVQH-KKLRTPLNYILLNLAVADLFMVFGgftTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIER 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 146 YFYIVHPMryeAKMTPWLSAAVMG--FVWVASTLLGLATVFGWPSY---GSRSSIAATHCSLHWSHSGHRrvFAILFCTL 220
Cdd:cd15080   99 YVVVCKPM---SNFRFGENHAIMGvaFTWVMALACAAPPLVGWSRYipeGMQCSCGIDYYTLKPEVNNES--FVIYMFVV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 221 CFCVPAAIIIAVYGN-VYKVAHTAARERgpipswtmatahpkrrsDSVNSQttiittstsvrrnQVPRRKRRTLVggkaa 299
Cdd:cd15080  174 HFTIPLIVIFFCYGRlVCTVKEAAAQQQ-----------------ESATTQ-------------KAEKEVTRMVI----- 218
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 300 ltlaIIVGQFLLCWLPY--FAFHLhlslgFSHSTSEeaEGPV-----TWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15080  219 ----IMVIAFLICWVPYasVAFYI-----FTHQGSD--FGPIfmtipAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
53-328 2.78e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 48.39  E-value: 2.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLcaallmplgiVCGSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSpmYFFVCSLAVADML----------VSVSNAWETITIYLLNNRHLVIEDAFV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 --------------ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpsYGSRSSIA 196
Cdd:cd15354   76 rhidnvfdslicisVVASMCSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFIL----YSESTYVI 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 197 ATHCSLhwshsghrrVFAILFctlcfcvpaaIIIAVYGNVYKVAHTAARERGPIPSWTMAtahpkrrsdsvnsqttiitt 276
Cdd:cd15354  152 ICLITM---------FFAMLF----------LMVSLYIHMFLLARTHVKRIAALPGYNSV-------------------- 192
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966710671 277 stsvrrnqvprRKRRTLvggKAALTLAIIVGQFLLCWLPYFafhLHLSLGFS 328
Cdd:cd15354  193 -----------RQRTSM---KGAVTLTILLGIFIVCWAPFF---LHLILMIS 227
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
52-180 3.20e-06

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 48.70  E-value: 3.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK------FSLVchlcIVDLLCAALLMPLGIV---CGSPFfagiVFSVLECRL 122
Cdd:cd15357    5 LVYAVIFVVGVIGNLLVCLVILKHQNMKTptnyylFSLA----VSDLLVLLFGMPLEVYemwSNYPF----LFGPVGCYF 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 123 YIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL 180
Cdd:cd15357   77 KTALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSI 134
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
52-362 3.23e-06

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 48.34  E-value: 3.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAaLLMPLGIVCGSPFFAGIvFSVLECRLYIFLNAF 129
Cdd:cd15131    5 VTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTnlYLSSMAFSDLLIF-LCMPLDLYRLWQYRPWN-FGDLLCKLFQFVSES 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVAStLLGLATVF---GWPSYGSRSSIAATHC--SLHW 204
Cdd:cd15131   83 CTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVS-FLSAGPIFvlvGVEHENGTNPIDTNECkaTEYA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 SHSGHRRVFAiLFCTLCFCVPAAIIIAVYGNVYKvahtaarergpiPSWtmatahpKRRsdsvnsqttiittstsvRRNQ 284
Cdd:cd15131  162 VRSGLLTIMV-WVSSVFFFLPVFCLTVLYSLIGR------------KLW-------RRR-----------------RENI 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 285 VPRRKRRTLVGGKAALTLAIIVGQFLLCWLPyfaFHLHLSLgFSHSTseEAEGPV------------TWLAYSTFAVNPF 352
Cdd:cd15131  205 GPNASHRDKNNRQTVKMLAVVVFAFVLCWLP---FHVGRYL-FSKSF--EAGSLEialisqycnlvsFVLFYLSAAINPI 278
                        330
                 ....*....|
gi 966710671 353 FYGLLNRQIR 362
Cdd:cd15131  279 LYNIMSKKYR 288
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
60-362 3.46e-06

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 48.33  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15978   13 LSVLGNSLIIAVLIRNKRMRTVTniFLLSLAVSDLMLCLFCMPFTLI--PNLLKDFIFGSAVCKTATYFMGISVSVSTFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLAtvfgWPSYGS------RSSIAATHCSLHWSHSGHRR 211
Cdd:cd15978   91 LVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLP----YPIYSNlvpftrINNSTGNMCRLLWPNDVTQQ 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 212 VFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARergpipsWTMAtahpkrrsdsvnsqttiittstsvrrnqvprrKRR 291
Cdd:cd15978  167 SWYIFLLLILFLIPGIVMMTAYGLISLELYRGIK-------FLMA--------------------------------KKR 207
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 292 TLvggkaaLTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW---LAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15978  208 VI------RMLIVIVILFFLCWTPIFSANAWRAFDTRSADRLLSGAPISFihlLSYTSACVNPIIYCFMNKRFR 275
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
59-365 3.63e-06

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 48.21  E-value: 3.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLmPLGIVCGSpFFAGIVFSVLECRLYIFLNAFLISASIF 136
Cdd:cd15191   12 ILGFLGNSLVVCVFCHQSGPKTVAsiYIFNLAVADLLFLATL-PLWATYYS-YGYNWLFGSVMCKICGSLLTLNLFASIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 137 TVTVISIERYFYIVHPMRYEAKmTPWLSAAVMGFVWVASTLLGLATVFGWPSYgSRSSIAATHCSLHWSHSGHRR---VF 213
Cdd:cd15191   90 FITCMSVDRYLAVVYPLRSQRR-RSWQARLVCLLVWVLACLSSLPTFYFRDTY-YIEELGVNACIMAFPNEKYAQwsaGL 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 214 AILFCTLCFCVPAAIIIAVYGNVYKvaHtaarergpipswTMATAHPkrrsdSVNSQttiittstsvRRNQVPRrkrrtl 293
Cdd:cd15191  168 ALMKNTLGFLIPLIVIATCYFGIGR--H------------LLKTKGF-----GKNKQ----------RRDKVLK------ 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 294 vggkaalTLAIIVGQFLLCWLPYFAFHLHLSLGFSH-------STSEEAEGPVT-WLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15191  213 -------MVAAVVLAFLICWFPFHVLTFLDALARMGvinncwvITVIDKALPFAiCLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
52-365 3.96e-06

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 48.28  E-value: 3.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLLCAALLMpLGIVCGSPF---FAGIVFSVLECRLYIFL 126
Cdd:cd15348    5 VAFLAVCAFIVLENLIVLLALWRNKkfHSPMFYLLGSLTLSDLLAGAAYA-ANILMSGANtlkLTPALWFLREGGVFITL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 nafliSASIFTVTVISIERYFYIVHPMRYEAKMTPWLsAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaathCS---LH 203
Cdd:cd15348   84 -----TASVFSLLAIAIERHITMVRMKPYPGDKRGRM-FLLIGAAWLVSILLGVLPILGWNCLGNLDA-----CStvlPL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WSHSghrrvfAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSwtmatahpkrrsdsvnsqttiittstsvrRN 283
Cdd:cd15348  153 YAKS------YILFCITVFLAILAAIVVLYARIYRIVKANSQRLGALPT-----------------------------RK 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 QVPRRKRRTLVGGKaalTLAIIVGQFLLCWLPYFA-FHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15348  198 GRARRSQKYLALLK---TVTIVLGTFVACWLPLFLlLLLDVSCPAQACPVLLKADYFLGLAMINSLLNPIIYTLTSRDMR 274

                 ...
gi 966710671 363 EEL 365
Cdd:cd15348  275 RAI 277
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
52-184 4.06e-06

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 48.32  E-value: 4.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMplgIVCGSP--------FFAGIVFSVLECRLY 123
Cdd:cd15356    5 AVYALIWALGAAGNALTIHLVLKKRSLRGLQGTVHYHLVSLALSDLLI---LLISVPielynfvwFHYPWVFGDLVCRGY 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF 184
Cdd:cd15356   82 YFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAF 142
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
81-186 5.67e-06

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 47.92  E-value: 5.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  81 FSLVCHLCIVDLLCAALLMPLGIVCGspffAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMT 160
Cdd:cd15071   36 FCFIVSLAVADVAVGALVIPLAIIIN----IGPQTEFYSCLMVACPVLILTQSSILALLAIAVDRYLRVKIPTRYKSVVT 111
                         90       100
                 ....*....|....*....|....*.
gi 966710671 161 PWLSAAVMGFVWVASTLLGLATVFGW 186
Cdd:cd15071  112 PRRAAVAIAGCWILSFLVGLTPMFGW 137
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
85-247 9.85e-06

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 47.00  E-value: 9.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  85 CHLCIVDLLCAALLMPLGIVCGSPffAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLS 164
Cdd:cd15376   41 FNLAVSDLLYALSLPLLAAYYYPP--KNWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHA 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 165 AAVMGFVWVASTLLGlATVFGWpSYGSRSSIAATHC------SLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYK 238
Cdd:cd15376  119 KLVSLAVWLLVAALS-APVLSF-SHLEVERHNKTEClgtavdSRLPTYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVLR 196

                 ....*....
gi 966710671 239 VAHTAARER 247
Cdd:cd15376  197 SPGITTLEK 205
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
59-362 1.14e-05

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 46.67  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKF--SLVCHLCIVDLLcAALLMPLGIVCGSpFFAGIVFSVLECRLYIFLNAFLISASIF 136
Cdd:cd15193   12 FTGLLGNLFVIALMSKRSTTKRLvdTFVLNLAVADLV-FVLTLPFWAASTA-LGGQWLFGEGLCKLSSFIIAVNRCSSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 137 TVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLatvfgwPSYGSRSSIAATHCSLHwSHSGHRRVFAIL 216
Cdd:cd15193   90 FLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGI------PSLVYRNLINESVCVED-SSSRFFQGISLA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 217 FCTLCFCVPAAIIIAVYGNVYKvahtaaRERGPIPSwtmatahpkrrsdsvnsqttiittstsvrRNQVPRRKRRTLvgg 296
Cdd:cd15193  163 TLFLTFVLPLIVILFCYCSILV------RLRRHFHG-----------------------------AKRTGRRRRNSL--- 204
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 297 KAALTlaiIVGQFLLCWLPYFAF---HLHLSLGfSHSTSEEAEGPVTW-------LAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15193  205 RIVFA---IVTAFVLSWLPFNTLkavRLLLELG-GGVLPCHTTVAIRQgltitacLAFVNSCVNPLIYSLLDRHFR 276
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
134-250 1.54e-05

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 46.10  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVaSTLLGLATVFGWPSYGSrssiaaTHCSLHWSHSghRRVF 213
Cdd:cd15164   84 SIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWV-LVIISVSLRLAWEEQEE------NFCFGKTSTR--PSKR 154
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 966710671 214 AILFCTLCFCVPAAII----IAVYGNVYKVAHTAARERGPI 250
Cdd:cd15164  155 TLIFSLLGFFIPLIILsfcsIQVIRSLKKKKKTNPHEEKLI 195
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
48-363 1.72e-05

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 45.92  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  48 MSGLVVMVTLNAIALLANSGVLTVV-VKVPHLRKFSLVCHLCIVDLLCAaLLMPLGIV--------CGSPFFAGIVFSVl 118
Cdd:cd15115    1 ILSLVVLSLTFLLGVPGNGLVIWVAgLKMKRTVNTIWFLNLAVADLLCC-LSLPFSIAhlllnghwPYGRFLCKLLPSI- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 119 ecrlyIFLNAFlisASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLatvfgwPSYGSRSSIAA- 197
Cdd:cd15115   79 -----IVLNMF---ASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCL------PVFIYRTTVTDg 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 --THCSLHWSHSGH--RRVFAilfctlcFCVPAAIIIAVYGNVykvahtaarergpipswtmatahpkrrsdsvnsqtti 273
Cdd:cd15115  145 nhTRCGYDFLVAITitRAVFG-------FLLPLLIIAACYSFI------------------------------------- 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 274 ittstsVRRNQVPRRKRRtlvGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGfshsTSEEAEGPVTW------LAYSTF 347
Cdd:cd15115  181 ------AFRMQRGRFAKS---QSKTFRVIIAVVVAFFVCWAPYHIIGILSLYG----DPPLSKVLMSWdhlsiaLAYANS 247
                        330
                 ....*....|....*.
gi 966710671 348 AVNPFFYGLLNRQIRE 363
Cdd:cd15115  248 CLNPVLYVFMGKDFKK 263
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
65-365 1.90e-05

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 45.93  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  65 NSGVLTVVVKVPHLRK--FSLVCHLCIVDLLcAALLMPLGIVcgspfFAGIVFSVLECRLYIFLNAFLISASIFTVTVIS 142
Cdd:cd15100   18 NAIVVAIIFSTPSLRApmFLLIGSLALADLL-AGLGLILHFV-----FRYCVYSEALSLVSVGLLVAAFSASVCSLLAIT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 143 IERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaathCSLHWSHSghrRVFAILFCtLCF 222
Cdd:cd15100   92 VDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNCLREGSS-----CSVVRPLT---KNHLAVLA-VAF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 223 CVPAAIIIAVYGNVYKV----AHTAARERGpipswTMATAHpkrrsdsvnsqttiittstsvrrnQVPRRKRRTlvggka 298
Cdd:cd15100  163 LLVFALMLQLYAQICRIvlrhAHQIALQRH-----FLAPSH------------------------YVATRKGVS------ 207
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 299 alTLAIIVGQFLLCWLPyfaFHLHLSLGFSHSTSEEAEGPVTWLAYSTFaVNPFFYGLLNRQIREEL 365
Cdd:cd15100  208 --TLALILGTFAACWIP---FAVYCLLGDGSSPALYTYATLLPATYNSM-INPIIYAFRNQDIQKVL 268
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
51-172 1.92e-05

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 45.99  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRKFSL---VCHLCIVDLLCAALLMPlGIVCGSPFFAGIVFSVLECRLYIFLN 127
Cdd:cd15941    4 FLLFLLIYLLTVLGNLLILLTIGSDPHLHGLPMyhfLGHLSFLDACLSSVTVP-KVLAGLLTLSGRTISFEGCVVQLYAF 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVW 172
Cdd:cd15941   83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTW 127
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
87-371 2.07e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 45.98  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIVCgSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPM---RYEAKMTPWL 163
Cdd:cd15306   42 LAVADLLVGLFVMPIALLT-ILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIqasQYNSRATAFI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 164 SAAVmgfVWVAStlLGLAtvFGWPSYGSRSSIAATH---CSLHWSHSGHrrvFAILFCTLCFCVPAAIIIAVYgnvykva 240
Cdd:cd15306  121 KITV---VWLIS--IGIA--IPVPIKGIETDVDNPNnitCVLTKERFGD---FILFGSLAAFFTPLAIMIVTY------- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 241 htaarergpipswtMATAHPKRRSDSVNSQttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFH 320
Cdd:cd15306  184 --------------FLTIHALRKQTITNEQ--------------------------RASKVLGIVFFLFLLMWCPFFITN 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966710671 321 LHLSLgfSHSTSEEAEGPV----TWLAYSTFAVNPFFYGLLNRQIREELCKMLFC 371
Cdd:cd15306  224 ITSVL--CDSCNQTTLQMLmeifVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
49-316 2.33e-05

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 45.84  E-value: 2.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  49 SGLVVMVTLnAIALLANSGVLTVVVKVPHLRKFS---LVChLCIVDLLC-AALLMPLGIVcgspFFAGI---VFSVLECR 121
Cdd:cd14995    3 ATFLVLLIC-GVGIVGNIMVVLVVLRTRHMRTPTncyLVS-LAVADLMVlVAAGLPNEIE----SLLGPdswIYGYAGCL 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 122 LYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTL-----LGLATVfgwpSYGSRSSIA 196
Cdd:cd14995   77 LITYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLycspwLFLLDL----SIKHYGDDI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 197 ATHCSLHWSHSGHRRVFaILFCTLCFCVPAAIIIAVYGNVYKVAHTAarergpipswtmatahpkrrsdsvnsqttiitt 276
Cdd:cd14995  153 VVRCGYKVSRHYYLPIY-LADFVLFYVIPLLLAIVLYGLIGRILFSS--------------------------------- 198
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 966710671 277 stsvrRNQVPRrkrrtlvggkaalTLAIIVGQFLLCWLPY 316
Cdd:cd14995  199 -----RKQVTK-------------MLAVVVVLFALLWMPY 220
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
122-362 2.57e-05

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 45.73  E-value: 2.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 122 LYIFLNAFLisasiftvtVISIERYFYIVHPMRyeAKMTPWLSAAVMGFVWVASTLLGLatvfgwPS-YGSRSSIAATH- 199
Cdd:cd15204   86 LYVSTNALL---------VIAIDRYLVIVHPLK--PRMKRRTACVVIALVWVVSLLLAI------PSaVYSKTTPYANQg 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 200 ---CSLHWS--HSGHRRVFAILFCTLCFCVPAAIIIAVYGNV-YKVAHTAArergpipswtmatahPKRRSDSvnsqtti 273
Cdd:cd15204  149 kifCGQIWPvdQQAYYKAYYLFLFVLEFVLPVLIMTLCYLRIvRKVWFRRV---------------PGQQTEQ------- 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 274 ittstsVRRNQvpRRKRRTLVggkaalTLAIIVGQFLLCWLPYFA------FHLHLSLGFSHSTSeeAEGPVTWLAYSTF 347
Cdd:cd15204  207 ------IRRRL--RRRRRKVR------LLVVILTAFVLCWAPYYGyaivrdFFPTLLSKEKLNTT--IFYIVEALAMSNS 270
                        250
                 ....*....|....*
gi 966710671 348 AVNPFFYGLLNRQIR 362
Cdd:cd15204  271 MINTVVYVAFNNNIR 285
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
50-354 2.61e-05

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 45.55  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  50 GLVVMVTLNAIALLANSGVLTVVVKvpHLRKFS----LVCHLCIVDLLcAALLMPLGIVcgspFFAGI--VFSVLECRLY 123
Cdd:cd14975    3 GCTLLSLAFAIGLPGNSFVIWSILI--KVKQRSvtmlLVLNLALADLA-VLLTLPVWIY----FLATGtwDFGLAACKGC 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 124 IFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLatvfgwPSYGSRSSIAAT---HC 200
Cdd:cd14975   76 VYVCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLAT------PVIAFRHVEETVengMC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 SLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYkvahtaarergpipswtmatahpkrrsdsvnsqttiittstsv 280
Cdd:cd14975  150 KYRHYSDGQLVFHLLLETVVGFAVPFTAVVLCYSCLL------------------------------------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 281 RRNQVPRRKRRtlvgGKAALTLAIIVGQFLLCWLPYFAFHL----------HLSLGFSHSTSEEAEGPVTWLAYSTFAVN 350
Cdd:cd14975  187 RRLRRRRFRRR----RRTGRLIASVVVAFAACWLPYHVGNLlevvseliggSKMAGTLGKVAEAGRPIAGALAFLSSSIN 262

                 ....
gi 966710671 351 PFFY 354
Cdd:cd14975  263 PLLY 266
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
52-323 2.81e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 45.54  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLLCA---------ALLMPLGIVCGSPFFAGIVFSVLEc 120
Cdd:cd15350    5 EVFFTIAAVGLLENLLVLVAVIKNKnlHSPMYFFICSLAVSDMLGSlyktlenilIILADMGYLNRRGPFETKLDDIMD- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 121 rlYIFLNAFLisASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpsygsrssiaathc 200
Cdd:cd15350   84 --SLFCLSLL--GSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCGGSGILMIL---------------- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 201 slhWSHSghrrVFAILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERGPIPSWtmatahpkrrsdsvnsqttiittstsv 280
Cdd:cd15350  144 ---FFHF----VATVICFTVLFFLMLVLILCLYVHMFLLARSHARKIASLPNH--------------------------- 189
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966710671 281 rrNQVPRRKrrtlvGGKAALTLAIIVGQFLLCWLPyFAFHLHL 323
Cdd:cd15350  190 --HAQHQRS-----NMRGAITLTILLGVFVCCWAP-FVLHLLL 224
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
52-365 2.86e-05

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 45.64  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAallmpLGIVCGSPFFAGIVFSVLECrLYIFLNAF 129
Cdd:cd15963    5 VVLCISGTVISCENAIVVAVIFYTPAFRApmFLLIGSLATADLLAG-----LGLILHFAFVYCIQSAPVNL-VTVGLLAP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaathCSLHWSHS-G 208
Cdd:cd15963   79 SFTASVSSLLAITIDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWNCLKDPST-----CSVVKPLTkN 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 209 HRRVFAILFCTLcFCVPAAIIIAVYGNVYKVAHTAARERGPIPSWTMATAHpkrrsdsvnsqttiittstsvrrnqvprr 288
Cdd:cd15963  154 HLVILSISFFMV-FALMLQLYAQICRIVCRHAHQIALQRHFLPTSHYVTTR----------------------------- 203
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 289 krrtlvggKAALTLAIIVGQFLLCWLPYFAFHLhlsLGFSHSTSEEAEGPVTWLAYSTFaVNPFFYGLLNRQIREEL 365
Cdd:cd15963  204 --------KGIATLAVILGTFASCWLPFAVYCL---LGDYTYPALYTYATLLPATYNSM-INPIIYAFRNQEIQKVL 268
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
60-365 3.47e-05

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 45.19  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFSLV-----CHLCIVDLLcAALLMPLGI--VCGSPFFAgivFSVLECRLYIFLNAFLIS 132
Cdd:cd15338   13 LGIIGNSIVIYTIVKKSKFRCQQTVpdifiFNLSIVDLL-FLLGMPFLIhqLLGNGVWH---FGETMCTLITALDTNSQI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVAStLLGLATVFGWP--------SYGSRSSIAATHCSLHW 204
Cdd:cd15338   89 TSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILS-LLSITPVWMYAglmplpdgSVGCALLLPNPETDTYW 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 205 shsghrrvFAILFCTLCFCVPAAIIIAVYgnvYKVAHTAARERGPIPswtmatahpkRRSDSVNSqttiittstsvrrnq 284
Cdd:cd15338  168 --------FTLYQFFLAFALPLVVICVVY---FKILQNMASTVAPLP----------QRSLRVRT--------------- 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 285 vpRRKRRTLVggkaALTLAiivgqFLLCWLPYFAFHL-HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIRE 363
Cdd:cd15338  212 --KKVTRMAV----AICLA-----FFICWAPFYILQLaHLSIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKR 280

                 ..
gi 966710671 364 EL 365
Cdd:cd15338  281 QF 282
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
83-365 3.79e-05

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 45.21  E-value: 3.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  83 LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEakmtPW 162
Cdd:cd15396   38 LIANLSLSDVLVCVMCIPFTAV--YTLMDHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAIERYQLIVNPRGWK----PS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 163 LSAAVMGFV--WVASTLLGLATVF-------GWPSYGSRSSIAATH--CSLHWSHSGHRRVFAILFCTLCFCVPAAIIIA 231
Cdd:cd15396  112 ASHAYWGIVliWLFSLMISIPFLIfhqltdePFRNLSSHSDFYKDKvvCIEAWPSETERLIFTTSLLVFQYFVPLGFIFI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 232 VYGNVYKVAHtaarergpipswtmatahpkRRSDSVNSqttiittstsVRRNQvprrkRRTLVGGKAALTLAIIVGQFLL 311
Cdd:cd15396  192 CYLKIFVCLK--------------------KRNSKIDR----------MRENE-----SRLSENKRINTMLISIVVTFAA 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 312 CWLPYFAFHL------------HLSLGFShstseeaegPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15396  237 CWLPLNIFNVvfdwnhevlmscHHNLVFT---------LCHLVAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
59-247 5.01e-05

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 44.63  E-value: 5.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRKFSLVCHLCIVDLLCAALLmpLGIVCGSPFFAGIV-----FSVLECRLYIFLNAFLISA 133
Cdd:cd15298    9 SLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLI--IGAFSMNLYTVYIIkgywpLGAVVCDLWLALDYVVSNA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGhrrvf 213
Cdd:cd15298   87 SVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNP----- 161
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 966710671 214 AILFCT--LCFCVPAAIIIAVYgnvYKVAHTAARER 247
Cdd:cd15298  162 AVTFGTaiAAFYLPVVIMTVLY---IHISLASARER 194
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
83-249 5.10e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 44.93  E-value: 5.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  83 LVCHLCIVDLLCAALLMPLGIVCGSPFFAgIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPW 162
Cdd:cd14981   40 LVAGLAITDLLGILLTSPVVLAVYASNFE-WDGGQPLCDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKR 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 163 LSAAVMGFVWVASTLLGLATVFGWPSYgsRSSIAATHCSLHWSHSGHR-RVFAILFCTLCFCVPAAII---IAVYGNVYK 238
Cdd:cd14981  119 RARLMLGAVWAFALLIASLPLLGLGSY--VLQYPGTWCFLDFYSKNTGdAAYAYLYSILGLLILLVTLlcnLLVIITLLR 196
                        170
                 ....*....|.
gi 966710671 239 VAHTAARERGP 249
Cdd:cd14981  197 MRRRKKRHRRS 207
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
114-184 5.25e-05

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 44.77  E-value: 5.25e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966710671 114 VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF 184
Cdd:cd15968   67 LFGDFMCRLVRFLFYFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILI 137
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
89-362 5.88e-05

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 44.44  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  89 IVDLLCAALLMPLGivcGSPFFAGIVFS------VLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYeaKMTPW 162
Cdd:cd15008   38 VVSMACADLLLSVA---SAPFVLLQFTSgrwtlgSAMCKLVRYFQYLTPGVQIYVLLSICVDRFYTIVYPLSF--KVSRE 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 163 LSAAVMGFVWVASTLLGLATVFgwpSYGSRSSiaaTHCSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAht 242
Cdd:cd15008  113 KAKKMIAASWLFDAAFVSPALF---FYGSNWG---PHCNFFLPDSWDGAAYAIIHLLVGFLVPSILIILFYQKVIKYI-- 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 243 aarergpipsWTMATAhpkrrsdsvnsqttiittSTSVRR--NQVPRRKRRTLvggKAALTLAIIvgqFLLCWLPYFAFH 320
Cdd:cd15008  185 ----------WRIGTD------------------GRTVRRtmNIVPRTKVKTI---KMFLMLNSM---FLLSWLPFYVVQ 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 966710671 321 LHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15008  231 LWHPRESDYRQSSLVFLAVTWISFSSSASKPTLYSVYNANFR 272
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
51-321 6.44e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 44.38  E-value: 6.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKvpHLRKFSL----VCHLCIVDLLCAAL-LMPLGIVCGSPFFAGIVFSvleCRLYIF 125
Cdd:cd15388    4 IAVLAIIFACALLSNSLVLLVLWR--RRKQLARmhvfMLHLCIADLVVAFFqVLPQLVWDITDRFRGPDVL---CRLVKY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVHPM-RYEAKMTPWLSAAVMGfvWVASTLLGLATVFGWpsygSRSSIAA--THCSL 202
Cdd:cd15388   79 LQVVGMFASSYMIVAMTFDRHQAICRPMvTFQKGRARWNGPVCVA--WAISLILSLPQVFIF----SKVEVAPgvYECWA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVAHtaarergpipswtmATAHPKRRSDSVNSQTTIITTSTSVRR 282
Cdd:cd15388  153 CFIEPWGLKAYVTWITLVVFVLPTLIITVCQVLIFKEIH--------------INIYLKSQIIVAVVKKKQLLSSRASSV 218
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 966710671 283 NQVPRRKRRTlvggkAALTLAIIVgQFLLCWLPYFAFHL 321
Cdd:cd15388  219 AEVSKAMIKT-----VKMTLVIVL-VYVLCWAPFFLVQL 251
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
93-229 6.72e-05

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135  Cd Length: 289  Bit Score: 44.48  E-value: 6.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  93 LCAALL-MPLGIV-CGSPFFAGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMryEAKMTPWLSAAVMGF 170
Cdd:cd15006   46 ICASLVcVPFDIVlSASPHCCWWIYTLLFCKVIKFLHKVFCSVTVLSFAAIALDRYYSVLYPL--ERKISDAKSRDLVIY 123
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 171 VWVASTllgLATVFGWPSYGSRSSIAATHCSLHWSHSGHRRVFAILFCTLCFCVPAAII 229
Cdd:cd15006  124 IWAHAV---VASVPVFAVTNVTDIYAMSTCTESWGYSLGHLVYVIIYNITTVILPVAVV 179
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
86-250 7.41e-05

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 44.31  E-value: 7.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  86 HLCIVDLLCAaLLMPLGIV-----CGSPFFAgivfsvLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMT 160
Cdd:cd15161   41 HLAVADLSYV-LILPMRLVyhlsgNHWPFGE------VPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRK 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 161 PWLSAAVMGFVWVastllgLATVFGWPSYGSRSSIAATH---CSLHWSHSGHRRvfAILFCTLCFCVPAAIIIAVYGNVY 237
Cdd:cd15161  114 PLYAHVVCGFLWV------IVTVAMAPLLVSPQTVEVNNttvCLQLYREKASRG--ALVSLAVAFTIPFVTTVTCYLLII 185
                        170
                 ....*....|...
gi 966710671 238 KVAHTAARERGPI 250
Cdd:cd15161  186 RSLRTGKREEKPL 198
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
87-371 8.23e-05

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 44.13  E-value: 8.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLeCRLYIFLNAFLISASIFTVTVISIERYFYIVHPM---RYEAKMTPWL 163
Cdd:cd15305   42 LAVADMLVGILVMPVSLIAILYDYAWPLPRYL-CPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIehsRFNSRTKAMM 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 164 SAAVmgfVWVASTLLGLATvfgwPSYGSRSS---IAATHCSLhwshsgHRRVFAILFCTLCFCVPAAIIIAVYgnvykva 240
Cdd:cd15305  121 KIAA---VWTISIGISMPI----PVIGLQDDekvFVNGTCVL------NDENFVLIGSFVAFFIPLIIMVITY------- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 241 htaarergpipswtMATAHPKRRSDSVNSQTtiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFH 320
Cdd:cd15305  181 --------------CLTIQVLQRQQAINNER-------------------------RASKVLGIVFFLFLIMWCPFFITN 221
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966710671 321 LHLSL---GFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREELCKMLFC 371
Cdd:cd15305  222 ILSVLckeACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
60-177 8.46e-05

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 43.98  E-value: 8.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPlGIVCGSPFFAGIVFSVLECRLYIFLNAFLISASIFT 137
Cdd:cd15916   13 LTVLGNLLILLTVWVDSHLHRpmYIFLGHLSFLDMWLSTVTVP-KMLAGFLEPGGKVISFGGCVAQLYFFHFLGSTECFL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966710671 138 VTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTL 177
Cdd:cd15916   92 YTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSL 131
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
115-234 8.73e-05

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 44.17  E-value: 8.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 115 FSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSs 194
Cdd:cd15089   67 FGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRD- 145
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966710671 195 iAATHCSLH-----WSHSGHRRVFAILFctlCFCVPAAIIIAVYG 234
Cdd:cd15089  146 -GAVVCMLQfpspsWYWDTVTKICVFIF---AFVVPILVITVCYG 186
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
65-365 9.24e-05

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 43.73  E-value: 9.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  65 NSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAallmpLGIVCGspFFAGIVFS---VLECRLYIFLNAFliSASIFTVT 139
Cdd:cd15960   18 NAIVIAILFYTPSLRApmFILIGSLALADLLAG-----LGLIAN--FVAIYVMNseaVTLCSAGLLLAAF--SASVCSLL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 140 VISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGHRRVFAILFct 219
Cdd:cd15960   89 AITVDRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIGLLPAMGWNCLRAPASCSVLRPVTKNNAAVLAVSFLLLF-- 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 220 lcfcvpaAIIIAVYGNVYKVAHTAARERgpipswtmatahpkrrsdSVNSQTTIITTSTSVRrnqvprrkrrtlvggKAA 299
Cdd:cd15960  167 -------ALMMQLYLQICRIAFRHAQQI------------------AVQHQFVNFCLASSTR---------------KGV 206
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 300 LTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPvtwlAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15960  207 STLSLILATFAFCWVPFAVYSMVADSSYPMIYTYYLVLP----AACNSVINPIIYAFRNPDIQKSL 268
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
53-233 9.25e-05

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 43.89  E-value: 9.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLAnsgvltvVVKVPHLR--KFSLVCHLCIVDLlcaALLMPLGIVCGSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15072   13 VGFSLNGLTILS-------FCKTRELRtpSNLLVLSLAVADM---GISLNALVAASSSLLRRWPYGSEGCQAHGFQGFFT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVHPMRYEakmtpWLSA-AVMGFVWVASTLLGLATVFGWPSYGSRssIAATHCSLHWShSGH 209
Cdd:cd15072   83 ALASICSSAAIAWDRYHHYCTRSKLQ-----WSTAiSLVLFVWLFSAFWAAMPLLGWGEYDYE--PLGTCCTLDYS-KGD 154
                        170       180
                 ....*....|....*....|....*...
gi 966710671 210 RR----VFAILFctLCFCVPAAIIIAVY 233
Cdd:cd15072  155 RNyvsyLFTMAF--FNFILPLFILLTSY 180
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
52-248 9.34e-05

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 43.74  E-value: 9.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVV------KVPHLrkfsLVCHLCIVDLLCAALLMPLGIV---CGSPFFAGIV--FSVLEC 120
Cdd:cd15964    5 IVVWFVNLLAILGNVFVLLILLtshyklTVPRF----LMCNLAFADFCMGIYLLLIASVdlhTRSEYYNHAIdwQTGPGC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 121 RLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYgSRSSIaathC 200
Cdd:cd15964   81 NTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLVGVSSY-AKVSI----C 155
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 966710671 201 SLHWSHSGHRRVFaILFCTLCFCVPAAIIIAVYGNVYKVAHTAARERG 248
Cdd:cd15964  156 LPMDTETPLAQAY-IVFVLMLNIIAFVIICACYIKIYITVRNPQYKSG 202
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
114-239 1.25e-04

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 43.75  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 114 VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWvASTLLGLATVFGWPSYGSRS 193
Cdd:cd15377   67 IFGDAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVW-LIVVVAISPILFYSGTGVRK 145
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966710671 194 SIAAThCSLHWSHSGHRRVFAILFCT--LCFCVPAAIIIAVYGNVYKV 239
Cdd:cd15377  146 NKTIT-CYDTTSDEYLRSYFIYSMCTtvAMFCVPFILILGCYGLIVRA 192
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
68-189 1.37e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 43.87  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  68 VLTVVVKVPHLRKFSLVCHLCIVDLLCAALLMPL---GIVCGSPFfagiVFSVLECRLYIFLNAFLISASIFTVTVISIE 144
Cdd:cd15218   23 ILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFvftSVKNGSTW----TYGTLTCKVIAFLGVLSCFHTAFMLFCISVT 98
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966710671 145 RYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSY 189
Cdd:cd15218   99 RYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTY 143
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
84-365 1.84e-04

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 42.88  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  84 VCHLCIVDLLcAALLMPLGI---------VCGSPFfAGIVFSVLECrlyiflNAFLISAsifTVTVISIERYFYIVHPMR 154
Cdd:cd15339   38 VCNLAVADLV-HIIVMPFLIhqwarggewVFGSPL-CTIITSLDTC------NQFACSA---IMTAMSLDRYIALVHPFR 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 155 YEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAAthCSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYg 234
Cdd:cd15339  107 LTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLES--CAFNLTSPDDVLWYTLYQTITTFFFPLPLILICY- 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 235 nVYKVAHTaarergpipsWTMATAHPKRRSDSvnsqttiittstsvrrNQVPRRKRRTLVggKAALTLaiiVGQFLLCWL 314
Cdd:cd15339  184 -ILILCYT----------WEMYRKNKKAGRYN----------------TSIPRQRVMRLT--KMVLVL---VGVFLVSAA 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966710671 315 PYFAFHL-HLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15339  232 PYHVIQLvNLSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
114-362 2.68e-04

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 42.48  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 114 VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF---GWPSYG 190
Cdd:cd15132   67 IFGEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFlvgVEQDNN 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 191 SRSSIAATHC--SLHWSHSGHRRVFaILFCTLCFCVPAAIIIAVYGNV-YKVAHTAARERGPIPSwtmatahpkrrsdsv 267
Cdd:cd15132  147 IHPDDFSRECkhTPYAVSSGLLGIM-IWVTTTYFFLPMLCLSFLYGFIgRKLWKSKNDLRGPNAA--------------- 210
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 268 nsqttiittstsvrrnQVPRRKRRTLvggkaaLTLAIIVGQFLLCWLPYfafhlHLSLGFSHSTSEEAEGPVTW------ 341
Cdd:cd15132  211 ----------------ARERSHRQTV------RILAVVVLAFIICWLPF-----HIGRILFANTEDYRTMMFSQyfniva 263
                        250       260
                 ....*....|....*....|...
gi 966710671 342 --LAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15132  264 mqLFYLSASINPILYNLISRKYR 286
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
53-321 2.81e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 42.48  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKvpHLRKFS----LVCHLCIVDLlCAALLMPLGIVCG--SPFFAGivfSVLECRLYIFL 126
Cdd:cd15386    6 VLAAILVVATAGNLAVLLAMYR--MRRKMSrmhlFVLHLALTDL-VVALFQVLPQLIWeiTYRFQG---PDLLCRAVKYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLISASIFTVTVISIERYFYIVHPMRyeAKMTPWLSAAVM-GFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWS 205
Cdd:cd15386   80 QVLSMFASTYMLIMMTVDRYIAVCHPLR--TLQQPSRQAYLMiGATWLLSCILSLPQVFIFSLREVDQGSGVLDCWADFG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 206 HSGHRRVFaILFCTLC-FCVPAAIIIAVYG--------NVYKVAHTAARERGPIPSWTMATahpkrRSDSVNSqttiitt 276
Cdd:cd15386  158 FPWGAKAY-ITWTTLSiFVLPVAILIVCYSlicyeickNLKGKTQTSRSEGGGWRTQGMPS-----RVSSVRT------- 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 966710671 277 stsvrrnqVPRRKRRTLvggkaALTLAIIVGqFLLCWLPYFAFHL 321
Cdd:cd15386  225 --------ISRAKIRTV-----KMTFVIVLA-YIACWAPFFSVQM 255
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
60-365 3.26e-04

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 42.35  E-value: 3.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLmPLGIVcgsPFFAGIVFSVLECRLYIFLnaFLIS--ASI 135
Cdd:cd15182   13 LSLLGNGLVLWILVKYEKLKTLTniFILNLAISDLLFTFTL-PFWAS---YHSSGWIFGEILCKAVTSI--FYIGfySSI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 136 FTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVAStllGLATVFGWPSYGSRSSiaaTHCSLHWSHSGHRRVF-A 214
Cdd:cd15182   87 LFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVIS---ILASLPELILSTVMKS---DEDGSLCEYSSIKWKLgY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 215 ILFCTLCFCVPAAIIIAVYGNVYKvahTAARERgpipswtmatahpkrrsdsvnsqttiittstsvrrnqvPRRKRRTLv 294
Cdd:cd15182  161 YYQQNLFFLIPLGIIVYCYVRILQ---TLMRTR--------------------------------------TMRKHRTV- 198
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966710671 295 ggkaALTLAIIVgQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTW-------LAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15182  199 ----KLIFVIVL-VFFLSWAPYNIVIFLRSLKDLTIPICECSKQLDYafyicrnIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
120-221 4.15e-04

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 41.96  E-value: 4.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWvASTLLGLATVFGWPSYGSRSSiaATH 199
Cdd:cd15201   73 CRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLW-LLTIAMTVYLLTKKHLFPRGN--ATQ 149
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 966710671 200 C-----SLHWSHSG--HRRVF---------AILFCTLC 221
Cdd:cd15201  150 CesfniCTGTDSSSnwHEAMFllefflplaIILYCSVR 187
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
134-253 5.14e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 41.67  E-value: 5.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 134 SIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLatvfgwPSYGSRSSIAATHCSLHWSHSGHRRVF 213
Cdd:cd15923   85 SIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISI------PYFLLDSSNEKTMCFQRTKQTESLKVF 158
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 966710671 214 aILFCTLCFCVPaaIIIAVYGNVyKVAHTAARERGPIPSW 253
Cdd:cd15923  159 -LLLEIFGFLLP--LIIMTFCSA-RVIHTLQKRLDDVGSR 194
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
59-181 5.38e-04

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 41.63  E-value: 5.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLLCAALLMP--LGIVC-GSpffAGIVFSVLECRLYiFLNAFLISA 133
Cdd:cd15950   12 VIALLGNGTILLVIKLDPslHEPMYYFLCMLAVIDLVMSTSIVPkmLSIFWlGS---AEISFEACFTQMF-FVHSFTAVE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966710671 134 SIFTVTViSIERYFYIVHPMRYEAKMTPwlsaAVMGFVWVASTLLGLA 181
Cdd:cd15950   88 SGVLLAM-AFDRYVAICHPLRYSAILTS----QVIAQIGLAIVLRALL 130
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
60-176 5.65e-04

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 41.28  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRK---FSLVcHLCIVDLLCAALLMPLGIVcgsPFFAGI-VFSVLECRLYIFLNAFLISASI 135
Cdd:cd15227   13 AALTGNLLIITVVTLDHHLHTpmyFFLK-NLSFLDLCYISVTVPKSIA---NSLTNTrSISFLGCVAQVFLFIFFAASEL 88
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966710671 136 FTVTVISIERYFYIVHPMRYEAKMTP----------WLSAAVMGFVWVAST 176
Cdd:cd15227   89 ALLTVMAYDRYVAICHPLHYEVIMNRgacvqmaaasWLSGLLYGALHTANT 139
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
114-362 6.01e-04

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 41.67  E-value: 6.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 114 VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL-ATVFGWPS---- 188
Cdd:cd15190   78 PFGSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALpALILRTTSdleg 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 189 ------YGSRSSIAATHCSLHWSHSghrrvFAILFCTLCFCVPAAIIIAVYGNvykVAHTAARERgpipswtmatAHPKR 262
Cdd:cd15190  158 tnkvicDMDYSGVVSNESEWAWIAG-----LGLSSTVLGFLLPFLIMLTCYFF---IGRTVARHF----------SKLRR 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 263 RSDsvnsqttiittstsvrrnqvpRRKRRTLvggKAALTLaiiVGQFLLCWLPYFAFH----------LHLSLGFSHSTS 332
Cdd:cd15190  220 KED---------------------KKKRRLL---KIIITL---VVTFALCWLPFHLVKtlyalmylgiLPFSCGFDLFLM 272
                        250       260       270
                 ....*....|....*....|....*....|
gi 966710671 333 eEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15190  273 -NAHPYATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
83-236 6.37e-04

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 41.34  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  83 LVCHLCIVDllCAALLMplgivcgSPFF------AGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYE 156
Cdd:cd15121   38 LVLNLALAD--AAVLLT-------APFFlhflsgGGWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKPFLSQ 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 157 AKMTPWLSAAVMGFVWVASTLLGLATVFgwpsYGSRSSIAATH--CSLHWSHSGHrRVFAILFCTLC-FCVPAAIIIAVY 233
Cdd:cd15121  109 KMRTKRSVRALLLAIWIVAFLLSLPMPF----YRTVLKKNINMklCIPYHPSVGH-EAFQYLFETITgFLLPFTAIVTCY 183

                 ...
gi 966710671 234 GNV 236
Cdd:cd15121  184 STI 186
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
108-178 6.46e-04

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 41.31  E-value: 6.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 108 PFFAGIV-------FSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTP-WLSAAVMGfVWVASTLL 178
Cdd:cd15120   53 PFMAVHVlmdnhwaFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNrWASAIVLG-VWISAILL 130
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
83-236 6.62e-04

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 41.33  E-value: 6.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  83 LVCHLCIVDllCAALLMplgivcgSPFF------AGIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYE 156
Cdd:cd15122   40 LILNLAVAD--GAVLLL-------TPFFitfltrKTWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 157 AKMTPWLSAAVMGFVWVASTLLGLATVFG---WPSYGSRSSIaathCSLHWSHSGHrRVFAILFCTL-CFCVPAAIIIAV 232
Cdd:cd15122  111 SLRKKALVRKILLAIWLLALLLALPAFVYrhvWKDEGMNDRI----CEPCHASRGH-AIFHYTFETLvAFVLPFGVILFS 185

                 ....
gi 966710671 233 YGNV 236
Cdd:cd15122  186 YSVI 189
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
101-319 7.40e-04

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 41.32  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 101 LGIVCGSPFFAGIV-------FSVLECRLY---IFLNAFLisaSIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGF 170
Cdd:cd15380   47 LVFVLGLPFWAENIrnqfnwpFGNFLCRVIsgvIKANLFI---SIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLL 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 171 VWVASTLLGLATvFGWPSYGSRSSIAATHCSLHWSHSGHRRVFAILFCTLCFCVPAAIIiaVYGNVYKVAHTAARERgpi 250
Cdd:cd15380  124 IWVFGGLLSIPT-FLFRSVKHVPDLNISACILLFPHEAWHFARRVELNIVGFLLPLAAI--VFFNFHIIASLRERTE--- 197
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966710671 251 pswtmatAHPKRRSDSVNSqttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPY--FAF 319
Cdd:cd15380  198 -------ESRKRCGGLKDT---------------------------KATRLILTLVLMFLVCWTPYhfFAF 234
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
59-177 7.75e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 41.09  E-value: 7.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLLCAALLMP--LGIVCGSPffAGIVFsvLECRLYIFLNAFLISAS 134
Cdd:cd15232   12 AAALTGNSLIILAISTSPklHTPMYFFLVNLSLVDIICTSTVVPklLQNLLTER--KTISF--GGCMAQLYFFTWSLGSE 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 966710671 135 IFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTL 177
Cdd:cd15232   88 LLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGML 130
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
125-236 8.30e-04

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 41.00  E-value: 8.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 125 FLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHW 204
Cdd:cd15360   85 FFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVALLPIFGISSYMKVSICLPMDIESPL 164
                         90       100       110
                 ....*....|....*....|....*....|..
gi 966710671 205 SHSghRRVFAILFCTLCFCVPAAIIIAVYGNV 236
Cdd:cd15360  165 SQA--YIIFILVLNVLAFLIICACYIKIYLTV 194
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
115-234 8.46e-04

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 40.85  E-value: 8.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 115 FSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVH-PMRYEAKMTPWLSAAVMGfVWVASTLLGLATVFGWPSygsrS 193
Cdd:cd15922   68 FGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHyNWKSLWKKKSFMKKLCLG-VWLLLFVQGLPFFFVLKT----S 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 966710671 194 SI-AATHC-SLHWS-HSGHRRVFAILFCTLCFCVPAAIIIAVYG 234
Cdd:cd15922  143 VIdGKTKClSIHQSeLSLLYFVWNFVLLILGFLLPFGVSLTCYA 186
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
52-237 9.03e-04

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 41.30  E-value: 9.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVV--VKVPHLRKFSLVcHLCIVDLLCAALLmPLGIVcGSPFFAGIvFSVLECRLYIFLNAF 129
Cdd:PHA03087  45 VVYSTIFFFGLVGNIIVIYVLtkTKIKTPMDIYLL-NLAVSDLLFVMTL-PFQIY-YYILFQWS-FGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpSYGSRSSIAATHCSLHW-SHSG 208
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILF---VYTTKKDHETLICCMFYnNKTM 197
                        170       180       190
                 ....*....|....*....|....*....|
gi 966710671 209 HRRVFA-ILFCTLCFCVPAAIIIAVYGNVY 237
Cdd:PHA03087 198 NWKLFInFEINIIGMLIPLTILLYCYSKIL 227
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
60-184 1.06e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 40.54  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRK---FSLvCHLCIVDLLCAALLMP--LGIvcgspFFAGI-VFSVLEC--RLYIFLnaFLI 131
Cdd:cd13954   13 LTLLGNLLIILLVRLDSRLHTpmyFFL-SNLSFLDICYTSVTVPkmLAN-----LLSGDkTISFSGCltQLYFFF--SLG 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966710671 132 SASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF 184
Cdd:cd13954   85 GTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTV 137
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
133-234 1.26e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 40.51  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLA-TVFGWPSYGSRSSIAATHCSLHWS-HSGHR 210
Cdd:cd15162   86 CSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPlYLVKQTIFLPALDITTCHDVLPEQlLVGDW 165
                         90       100
                 ....*....|....*....|....
gi 966710671 211 RVFAILFCTLCFCVPAAIIIAVYG 234
Cdd:cd15162  166 FYYFLSLAIVGFLIPFILTASCYV 189
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
52-365 1.30e-03

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 40.49  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKfslVCHLCIVDLLCA----ALLMPLGIVcgSPFFAGIVFSVLECRLYIFLN 127
Cdd:cd15087    5 VIYSVICAVGLTGNTAVIYVILRAPKMKT---VTNVFILNLAIAddlfTLVLPINIA--EHLLQQWPFGELLCKLILSID 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMRyeAKMTPW----LSAAVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLH 203
Cdd:cd15087   80 HYNIFSSIYFLTVMSVDRYLVVLATVR--SRRMPYrtyrAAKIVSLCVWLLVTIIVLPFTVFAGVYSNELGRKSCVLSFP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 204 WSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKvahtaarergpipswtmatahpKRRSDSVNSQTtiittstsvrrN 283
Cdd:cd15087  158 SPESLWFKASRIYTLVLGFAIPVSTICILYTMMLY----------------------KLRNMRLNSNA-----------K 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 284 QVPRRKRrtlvggKAALTLAIIVGQFLLCWLPyfaFHLHLSLGFshsTSEEAEGP--------VTWLAYSTFAVNPFFYG 355
Cdd:cd15087  205 ALDKAKK------KVTLMVLVVLAVCLFCWTP---FHLSTVVAL---TTDLPQTPlvigisyfITSLSYANSCLNPFLYA 272
                        330
                 ....*....|
gi 966710671 356 LLNRQIREEL 365
Cdd:cd15087  273 FLDDSFRKSF 282
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
52-365 1.43e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 40.21  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRKfslvchlcivdllcAALLMPLGIVCGSPFFAGIVFSVLECRLYIF-----L 126
Cdd:cd15341    5 VLCTLCGLLCILENVAVLYLILSSPKLRR--------------KPSYLFIGSLALADFLASVVFACSFVDFHVFhgvdsS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLI---------SASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWpsygsrssiaa 197
Cdd:cd15341   71 AIFLLklggvtmsfTASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLMGW----------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 THCSLHWSHSghrRVFAI-----LFCTLCF-CVPAAIIIAVYGNVYKVAHTaarergpipswtmATAHPKRRSDsvnsqt 271
Cdd:cd15341  140 NCCPLNSPCS---ELFPLipndyLLSWLLLvAILLSGIIYTYGHVLWKAHK-------------HVVYMEKHQD------ 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 272 tiittstsvrrNQVPRRKRRTLvGGKAALTLAIIVGQFLLCWLPYFAFHLHlSLGFSHSTS-EEAEGPVTWLAYSTFAVN 350
Cdd:cd15341  198 -----------QQGPGNARMRL-DVRLAKTLGLVLAVLLICWSPVLALMMH-SLFTSLSDHiKKAFAFCSTLCLVNSMVN 264
                        330
                 ....*....|....*
gi 966710671 351 PFFYGLLNRQIREEL 365
Cdd:cd15341  265 PIIYALRSRELRSSL 279
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
59-172 1.67e-03

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 40.13  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  59 AIALLANSGVLTVVVKVPHLRK---FSLVCHLCIVDLLCAALLMPLgiVCGSPFFAGIVFSVLECRLYIFLNAFLISASI 135
Cdd:cd15935   12 AAILLGNLLIVVTVHADPHLLQspmYFFLANLSLIDMTLGSVAVPK--VLADLLTCGRTISFGGCMAQLFFLHFLGGSEM 89
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 966710671 136 FTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVW 172
Cdd:cd15935   90 LLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACW 126
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
97-362 1.70e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 40.19  E-value: 1.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  97 LLMPLGIVCGSPFFAGIVFSVL--------ECRLYIFLNAFLISASIFTVTV-----------ISIERYFYIVHPM---R 154
Cdd:cd15076   31 LRQPLNYILVNISLAGFIFCIFsvfpvfvaSAQGYFFFGRTVCALEAFVGSLaglvtgwslafLAFERYIVICKPFgnfR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 155 YEAKMtpwlSAAVMGFVWVASTLLGLATVFGWPSYGSRSsiAATHCSLHWSHSGHR---RVFAILFCTLCFCVPAAIIIA 231
Cdd:cd15076  111 FGSKH----ALGAVVATWIIGIGVSLPPFFGWSRYIPEG--LQCSCGPDWYTVGTKyrsEYYTWFLFIFCFIVPLSIIIF 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 232 VYGNVYKVAHTAARErgpipswtmatahpkrRSDSVNSQttiittstsvrrnQVPRRKRRTLVggkaaltlaIIVGQFLL 311
Cdd:cd15076  185 SYSQLLGALRAVAAQ----------------QQESASTQ-------------KAEREVSRMVV---------VMVGSFCL 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966710671 312 CWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15076  227 CYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
87-362 2.03e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 39.92  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  87 LCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLeCRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAA 166
Cdd:cd15304   42 LAIADMLLGFLVMPVSMLTILYGYRWPLPSKL-CAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFL 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 167 VMGFVWVASTLLGLATvfgwPSYGSRSS---IAATHCSLHWSHsghrrvFAILFCTLCFCVPAAIIIAVYgnvykvahta 243
Cdd:cd15304  121 KIIAVWTISVGISMPI----PVFGLQDDskvFKEGSCLLADEN------FVLIGSFVAFFIPLTIMVITY---------- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 244 arergpipswtMATAHPKRRSDSvNSQttiittstsvrrnqvprrkrrtlvggKAALTLAIIVGQFLLCWLPYFAFHLhL 323
Cdd:cd15304  181 -----------FLTIKSLQQSIS-NEQ--------------------------KASKVLGIVFFLFVVMWCPFFITNV-M 221
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 966710671 324 SLGFSHSTSEEAEGPV----TWLAYSTFAVNPFFYGLLNRQIR 362
Cdd:cd15304  222 AVICKESCNEVVIGGLlnvfVWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
62-184 2.15e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 39.77  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  62 LLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLECRLYIFLnAFLISASIFtVT 139
Cdd:cd15946   15 LLGNGLIITLICLDSRLHTpmYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL-ALGITECTL-FS 92
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966710671 140 VISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF 184
Cdd:cd15946   93 VMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTF 137
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
122-180 2.34e-03

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 39.52  E-value: 2.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966710671 122 LYIFLnaFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL 180
Cdd:cd15918   77 MYFFL--LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSL 133
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
60-236 2.71e-03

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 39.35  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  60 IALLANSGVLTVVVKVPHLRKFSLV--CHLCIVDLLcaallmplgIVCGSPFFA-----GIVFSVLECRLYIFLNAFLIS 132
Cdd:cd15174   13 VGAVGNSLVVLIYTYYRRRKTMTDVylLNLAIADLL---------FLCTLPFWAtaassGWVFGTFLCKVVNSMYKINFY 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 133 ASIFTVTVISIERYFYIVHPMRYEAKMTPWL--SAAVMGFVWVASTLLGLATVFgwpSYGSRSSIAATHCSL-HWSHSGH 209
Cdd:cd15174   84 SCMLLLTCISVDRYIAIVQATKAHNSKNKRLlySKLVCFFVWLLSTILSLPEIL---FSQSKEEESVTTCTMvYPSNESN 160
                        170       180
                 ....*....|....*....|....*....
gi 966710671 210 RRVFAILFCTLC--FCVPAAIIIAVYGNV 236
Cdd:cd15174  161 RFKVAVLALKVTvgFFLPFVVMVICYTLI 189
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
114-180 2.73e-03

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 39.35  E-value: 2.73e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 114 VFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL 180
Cdd:cd14991   67 IFGEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTL 133
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
115-365 2.97e-03

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 39.33  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 115 FSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFgwpSYGSRSS 194
Cdd:cd15117   67 FGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLV---FRDTRKE 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 195 IAATHCSLH---WSHSGHRRVF------------AILFCTLCFCVPAAIIIAVYGNVykvahtAARergpipSWTMATAH 259
Cdd:cd15117  144 NGCTHCYLNfdpWNETAEDPVLwletvvqrlsaqVITRFVLGFLVPLVIIGGCYGLI------AAR------LWREGWVH 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 260 PKRrsdsvnsqttiittstsvrrnqvPRRkrrtlvggkaalTLAIIVGQFLLCWLPyfaFHLHLSLGFShSTSEEAEG-- 337
Cdd:cd15117  212 SSR-----------------------PFR------------VLTAVVAAFFLCWFP---FHLVSLLELV-VILNQKEDln 252
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 966710671 338 --------PVTWLAYSTFAVNPFFYGLLNRQIREEL 365
Cdd:cd15117  253 pllilllpLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
84-365 2.97e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 39.29  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  84 VCHLCIVDLLcAALLMPLGIVcgspFFA---GIVFSVLECRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMT 160
Cdd:cd15160   39 LLNLSLSDLL-YILTLPLWID----YTAnhhNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRT 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 161 PWLSAAVMGFVWVasTLLGLATVFGWPSYGSRSSIAATHCSLHWSHSGHRRVFAILFCTLCFCVPAAIIIAVYGNVYKVa 240
Cdd:cd15160  114 RRFALKVSASIWV--LELGTHSVFLGHDELFRDEPNHTLCYEKYPMEGWQASYNYARFLVGFLIPLSLILFFYRRVLRA- 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 241 htaarergpipswtmatahpkrrsdsvnsqttiittstsVRRNQVPRRKRRTLVGGKAALTLAIivgqFLLCWLPYFAFH 320
Cdd:cd15160  191 ---------------------------------------VRQSPSLEREEKRKIIGLLLSIVVI----FLLCFLPYHVVL 227
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966710671 321 LHLSLGFS----HSTSEEAEGPVTWLAYSTFAVN----PFFYGLLNRQIREEL 365
Cdd:cd15160  228 LVRSVIELvqngLCGFEKRVFTAYQISLCLTSLNcvadPILYIFVTEDVRQDL 280
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
51-177 3.57e-03

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 38.95  E-value: 3.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVP--HLRKFSLVCHLCIVDLLCAALLMPLgiVCGSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd15228    4 FVLFLAFYLCTLLGNLLILSAILSDPrlHTPMYFFLCNLSVFDIGFSSVSTPK--MLAYLWGQSRVISLGGCMSQVFFYH 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTL 177
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSF 130
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
53-354 3.61e-03

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 39.05  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFS--LVCHLCIVDLLCAALLMPLGIVcgSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15404    6 VMIFILLVSFLGNFVVCLMVYQKAAMRSAIniLLASLAFADMMLAVLNMPFALV--TIITTRWIFGDAFCRVSAMFFWLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 131 ISASIFTVTVISIERYFYIVhpmRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPSYGSRSSiaATHCSLHWSHSGHR 210
Cdd:cd15404   84 VMEGVAILLIISIDRFLIIV---QKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPSR--APQCVFGYTTNPGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 211 RVFAILFCTLCFCVPAAIIIAVYGNVYkvahtaarergpipswtmatahpkrrsdsvnsqttiittstsvrrNQVPRRKR 290
Cdd:cd15404  159 QAYVILIMLIFFFIPFMVMLYSFMGIL---------------------------------------------NTVRSFKT 193
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966710671 291 RtlvggkAALTLAIIVGQFLLCWLPYFAFHL--HLSLGFSHSTS-EEAEGPVTWLAYSTFAVNPFFY 354
Cdd:cd15404  194 R------AFTTILILFIVFTVCWAPFTTYSLvaTFNSHFYHKHNfFEISTWLLWLCYLKSALNPLIY 254
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
54-178 4.24e-03

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 38.81  E-value: 4.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  54 MVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMP--LGIVcgspFFAGIVFSVLECRLYIFLNAF 129
Cdd:cd15223    7 FLLLYLVALVANSLLLLIIKLERSLHQpmYILLGILAAVDIVLATTILPkmLAIF----WFDANTISLPGCFAQMFFIHF 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966710671 130 LISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLL 178
Cdd:cd15223   83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLL 131
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
53-325 4.63e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 38.62  E-value: 4.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAA---------LLMPLG-IVCGSPFFAGI--VFSVL 118
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSpmYYFICCLAVSDMLVSVsnlietlfmLLLEHGvLVCRAPMLQHMdnVIDTM 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 119 ECRLYIFLNAFLisasiftvTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLglATVFgwpsygsrssiaat 198
Cdd:cd15351   86 ICSSVVSSLSFL--------GAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVS--STLF-------------- 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 199 hCSLHWSHsghrrvfAILFCTLCFCVPAAIIIAV-YGNVYKVAHtaarergpipswtmatahpkRRSDSVNSQttiitts 277
Cdd:cd15351  142 -IVYYNSN-------AVILCLIVFFLFMLVLMLVlYIHMFILAC--------------------RHSQSISSQ------- 186
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 966710671 278 tsvRRNQVPRRKRRTLvggKAALTLAIIVGQFLLCWLPYFafhLHLSL 325
Cdd:cd15351  187 ---QRRQCPHQQTASL---KGAITLTILLGIFFLCWGPFF---LHLTL 225
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
51-184 4.87e-03

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 38.46  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  51 LVVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMPLgiVCGSPFFAGIVFSVLECRLYIFLNA 128
Cdd:cd15420    4 FGLFSLLYIFTLLGNGLILGLIWLDSRLHTpmYFFLSHLAVVDICYASSTVPH--MLGNLLKQRKTISFAGCGTQMYLFL 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVF 184
Cdd:cd15420   82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVV 137
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
120-354 4.94e-03

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 38.39  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 120 CRLYIFLNAFLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTllGLATVFGW----PSYGSRSSI 195
Cdd:cd15170   74 CPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAF--SHCSIVYIveyhIDSENTSVT 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 196 AATHCSLHWSHSGHRRVFAI---LFCTLcFCVPAAIIIAVYGNVYKVAHTaarergpipswtmatahpkrrsdsvnsqtt 272
Cdd:cd15170  152 NNSRCYDNFTPEQLKILLPVrleLFLVL-FCIPFLITCFCYINFIRILSS------------------------------ 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 273 iittstsvRRNQVPRRKRRTLvgGKAALTLAIivgqFLLCWLPYFAFHLhlsLGFSHSTSEEaegpvtWLAY----STF- 347
Cdd:cd15170  201 --------LPHISRQRKQRAI--GLAVATLLN----FIVCFAPYNISHV---VGFIQRKSPE------WRMYalllSTLn 257

                 ....*....
gi 966710671 348 -AVNPF-FY 354
Cdd:cd15170  258 aCLDPIiFY 266
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-365 5.91e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 38.28  E-value: 5.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRkfslvchlcivdllCAALLMPLGIVCGSPFFAGIVFSVLECRLYIF-----L 126
Cdd:cd15099    5 VLCFLAGPVTFLENILVLLTILSSTALR--------------RRPSYLFIGSLALADMLASVIFTISFLDFHVFhqrdsR 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 127 NAFLI---------SASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWpsygsRSSIAA 197
Cdd:cd15099   71 NLFLFklggvtmafTASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLMGW-----RCKTWD 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 198 THCSLHWSH-SGHRRVFAILFCTLCFcvpaAIIIAVYGNVYKVAHT-AARERGPipswtmatahpkrrsdsvnsqttiit 275
Cdd:cd15099  146 SPCSRLFPYiDRHYLASWTGLQLVLL----FLIIYAYPYILWKAHRhEANMGGP-------------------------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 276 tstSVRRNQVPRRKRRTLvGGKAALTLAIIVGQFLLCWLPYFAFHLHLSLGFSHSTSEEAEGPVTWLAYSTFAVNPFFYG 355
Cdd:cd15099  196 ---KLGRQQVKGQARMRM-DIRLAKTLSLILLVLAICWLPVLAFMLVDVRVTLTNKQKRMFAFCSMLCLVNSCVNPIIYA 271
                        330
                 ....*....|
gi 966710671 356 LLNRQIREEL 365
Cdd:cd15099  272 LRSRELRGAM 281
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
53-354 6.17e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 38.26  E-value: 6.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPhlRKFS----LVCHLCIVDLLCAAL-LMPLGIVCGSPFFAGIVFSvleCRLYIFLN 127
Cdd:cd15385    6 VLAVIFAVAVIGNSSVLLALYKTK--KKASrmhlFIKHLSLADLVVAFFqVLPQLCWDITYRFYGPDFL---CRIVKHLQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 128 AFLISASIFTVTVISIERYFYIVHPMR--YEAKMTPWLsaaVMGFVWVASTLLGLATVFGWPSYGSRSSIAATHCSLHWS 205
Cdd:cd15385   81 VLGMFASTYMLVMMTADRYIAICHPLKtlQQPTKRSYL---MIGSAWALSFILSTPQYFIFSLSEIENGSGVYDCWANFI 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 206 HSGHRRVFAILFCTLCFCVPAAIIIAVYGNVykvAHTAARErgpIPSWTMatahpKRRSDSVNSQTTIITTSTSVRrnQV 285
Cdd:cd15385  158 VPWGIKAYITWITISIFVVPVIILLTCYGFI---CYNIWRN---IKCKTR-----RGLSDNALKNILLAVCVSSVK--TI 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966710671 286 PRRKRRTLvggkaALTLaIIVGQFLLCWLPYFAFHLhLSLGFSHSTSEEAEGPVT----WLAYSTFAVNPFFY 354
Cdd:cd15385  225 SRAKIRTV-----KMTF-VIVLAYIVCWAPFFTIQM-WSVWDQNFPWDESENTAVtitaLLASLNSCCNPWIY 290
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
52-180 7.18e-03

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 37.97  E-value: 7.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLCAALLMP---LGIVCGSPffaGIVFSVLECRLYIFL 126
Cdd:cd15235    6 LLFLAMYLLTLLGNLLIVLLIRSDPRLHTpmYFFLSHLSLVDICFTSTTVPkmlANLLSGSK---TISYAGCLAQMYFFI 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966710671 127 nAFLISASiFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL 180
Cdd:cd15235   83 -AFGNTDS-FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSL 134
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
53-249 7.55e-03

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 38.22  E-value: 7.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRKFSLVC--HLCIVDLLcaaLLMPLgivcgsPFFA-----GIVFSVLECRLYIF 125
Cdd:cd15177    6 VYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYllNLALADLL---LLLTL------PFAAaetlqGWIFGNAMCKLIQG 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 126 LNAFLISASIFTVTVISIERYFYIVH--PMRYEAKMTPWLSAAVMGFVWVASTLLGLATVfgwpSYGSRSSIAATH-CSL 202
Cdd:cd15177   77 LYAINFYSGFLFLTCISVDRYVVIVRatSAHRLRPKTLFYSVLTSLIVWLLSILFALPQL----IYSRVENRSELSsCRM 152
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966710671 203 HWSHSGHRRV---FAILFCTLCFCVPAAIIIAVYGnvyKVAHTAARERGP 249
Cdd:cd15177  153 IFPEVVSRTVkgaTALTQVVLGFAIPLIVMAVCYA---AIGRTLLAARGW 199
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
52-188 7.60e-03

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 37.97  E-value: 7.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  52 VVMVTLNAIALLANSGVLTVVVKVPHLRK---FSLvCHLCIVDLLCAALLMPLGIVCGSPFFAGIVFSVLECRLYIFLna 128
Cdd:cd15431    5 VLLLIVYLVTLLGNGLIILLIRVDSQLHTpmyFFL-SNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL-- 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671 129 FLISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGLATVFGWPS 188
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTMPL 141
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
53-180 9.45e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 37.56  E-value: 9.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966710671  53 VMVTLNAIALLANSGVLTVVVKVPHLRK--FSLVCHLCIVDLLcaallmplgiVCGSPFFAGIVFSVLECRLYIFLNAFL 130
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSpmYFFLCSLAVADML----------VSVSNSLETIMIAVLNSGYLVISDQFI 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966710671 131 --------------ISASIFTVTVISIERYFYIVHPMRYEAKMTPWLSAAVMGFVWVASTLLGL 180
Cdd:cd15352   76 qhmdnvfdsmicisLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGI 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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