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Conserved domains on  [gi|975098749|ref|XP_015264389|]
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PREDICTED: transmembrane protein 132C-like, partial [Gekko japonicus]

Protein Classification

TMEM132 and TMEM132D_C domain-containing protein( domain architecture ID 11756457)

TMEM132 and TMEM132D_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 185-269 5.36e-52

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464814  Cd Length: 84  Bit Score: 168.24  E-value: 5.36e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975098749  185 TNFPAQIDLPKNDGsMDDSDLVQAPRGLSDLEIGMYALLGVFCLAILVFLINCATFTLKYRHKQVPVEGQATMSHSHDWV 264
Cdd:pfam15706   1 TNFPAQTDAPNNNG-ESEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWV 79


                  ....*
gi 975098749  265 WLGNE 269
Cdd:pfam15706  80 WLGRE 84
TMEM132 super family cl25648
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 1-74 6.68e-34

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


The actual alignment was detected with superfamily member pfam16070:

Pssm-ID: 465003  Cd Length: 344  Bit Score: 128.94  E-value: 6.68e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 975098749    1 EAILSSWIQFSDGSVTPLDIYDPKDFSLSASSLDESVVSAHLSSTTKWPVVAAEGEGQGMLVKVDMMISEACQK 74
Cdd:pfam16070 271 EALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPVVVAEGEGQGPLVRVELTISEACQK 344
 
Name Accession Description Interval E-value
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 185-269 5.36e-52

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 168.24  E-value: 5.36e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975098749  185 TNFPAQIDLPKNDGsMDDSDLVQAPRGLSDLEIGMYALLGVFCLAILVFLINCATFTLKYRHKQVPVEGQATMSHSHDWV 264
Cdd:pfam15706   1 TNFPAQTDAPNNNG-ESEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWV 79


                  ....*
gi 975098749  265 WLGNE 269
Cdd:pfam15706  80 WLGRE 84
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 1-74 6.68e-34

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 128.94  E-value: 6.68e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 975098749    1 EAILSSWIQFSDGSVTPLDIYDPKDFSLSASSLDESVVSAHLSSTTKWPVVAAEGEGQGMLVKVDMMISEACQK 74
Cdd:pfam16070 271 EALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPVVVAEGEGQGPLVRVELTISEACQK 344
 
Name Accession Description Interval E-value
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 185-269 5.36e-52

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 168.24  E-value: 5.36e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975098749  185 TNFPAQIDLPKNDGsMDDSDLVQAPRGLSDLEIGMYALLGVFCLAILVFLINCATFTLKYRHKQVPVEGQATMSHSHDWV 264
Cdd:pfam15706   1 TNFPAQTDAPNNNG-ESEGDLVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPVPHSHDWV 79


                  ....*
gi 975098749  265 WLGNE 269
Cdd:pfam15706  80 WLGRE 84
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 1-74 6.68e-34

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 128.94  E-value: 6.68e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 975098749    1 EAILSSWIQFSDGSVTPLDIYDPKDFSLSASSLDESVVSAHLSSTTKWPVVAAEGEGQGMLVKVDMMISEACQK 74
Cdd:pfam16070 271 EALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRWPVVVAEGEGQGPLVRVELTISEACQK 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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