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Conserved domains on  [gi|66880553|ref|NP_000126|]
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Fanconi anemia group A protein isoform a [Homo sapiens]

Protein Classification

Fanconi_A_N and Fanconi_A domain-containing protein( domain architecture ID 11239481)

Fanconi_A_N and Fanconi_A domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Fanconi_A_N pfam15865
Fanconi anaemia group A protein N terminus;
170-524 0e+00

Fanconi anaemia group A protein N terminus;


:

Pssm-ID: 464911  Cd Length: 355  Bit Score: 595.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    170 LWKI--QSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLCEQMEASCQHADVARAMLSDFVQMFVLRGf 247
Cdd:pfam15865    1 LWRIleQQCLLLEVVWQLHVLNILTLTELLESHEDSQALQVWLFRFLCLLCEQIEASCQHTETERALLSDFVQMFVLRG- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    248 qKNSDLRRTVEPEKMPQVTVDVLQRMLIFALDALAAGVQEESSTHKIVRCWFGVFSGHTLGSVISTDPLKRFFSHTLTQI 327
Cdd:pfam15865   80 -KNSDLRRAAEDEKMPQVLTAVLQRMLSFLLDALAANPQEESLAYKAVRCWFGVFSGSTLCSSLSDDALKRFFSHTLTQL 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    328 LTHSPVLKASDAVQMQREWSFARTHPLLTSLYRRLFVMLSAEELVGHLQEVLETQEVHWQRVLSFVSALVVCFPEAQQLL 407
Cdd:pfam15865  159 LTLHPVLKVSDAIQMQSEWSFARTDELLTTLYRRLFVKLSPEELLGHLQEVLETHEVNWKHVLSCVSTLVVCAPEAQQLI 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    408 EDWVARLMAQAFESCQLDSMVTAFLVVRQAALEGPSAFLSYADWFKASFGSTRGYHGCSKKALVFLFTFLSELVPFESPR 487
Cdd:pfam15865  239 KDWLKRLLARAFESGDLDSMVTAFLTARQAALEGPNVFPSYADWFKQSFGEMSGYHGCSKKALVFLLKFLSDLVPFEPPQ 318
                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 66880553    488 YLQVHILHPPLVPGKYRSLLTDYISLAKTRLADLKVS 524
Cdd:pfam15865  319 YLKVHILHPPLVPGKYRSLLQDYKTLAKTRLADLKVS 355
Fanconi_A pfam03511
Fanconi anaemia group A protein;
1266-1312 6.05e-19

Fanconi anaemia group A protein;


:

Pssm-ID: 460952  Cd Length: 63  Bit Score: 82.05  E-value: 6.05e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 66880553   1266 MGLLSSHLTSNSTTDLPKAFHVCAAILECLEKRKISWLALFQLTESD 1312
Cdd:pfam03511   13 MGLLSSHLTPKEAVDSLKALDVCAEILGCLEKRKVSWLVLFQLTETD 59
 
Name Accession Description Interval E-value
Fanconi_A_N pfam15865
Fanconi anaemia group A protein N terminus;
170-524 0e+00

Fanconi anaemia group A protein N terminus;


Pssm-ID: 464911  Cd Length: 355  Bit Score: 595.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    170 LWKI--QSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLCEQMEASCQHADVARAMLSDFVQMFVLRGf 247
Cdd:pfam15865    1 LWRIleQQCLLLEVVWQLHVLNILTLTELLESHEDSQALQVWLFRFLCLLCEQIEASCQHTETERALLSDFVQMFVLRG- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    248 qKNSDLRRTVEPEKMPQVTVDVLQRMLIFALDALAAGVQEESSTHKIVRCWFGVFSGHTLGSVISTDPLKRFFSHTLTQI 327
Cdd:pfam15865   80 -KNSDLRRAAEDEKMPQVLTAVLQRMLSFLLDALAANPQEESLAYKAVRCWFGVFSGSTLCSSLSDDALKRFFSHTLTQL 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    328 LTHSPVLKASDAVQMQREWSFARTHPLLTSLYRRLFVMLSAEELVGHLQEVLETQEVHWQRVLSFVSALVVCFPEAQQLL 407
Cdd:pfam15865  159 LTLHPVLKVSDAIQMQSEWSFARTDELLTTLYRRLFVKLSPEELLGHLQEVLETHEVNWKHVLSCVSTLVVCAPEAQQLI 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    408 EDWVARLMAQAFESCQLDSMVTAFLVVRQAALEGPSAFLSYADWFKASFGSTRGYHGCSKKALVFLFTFLSELVPFESPR 487
Cdd:pfam15865  239 KDWLKRLLARAFESGDLDSMVTAFLTARQAALEGPNVFPSYADWFKQSFGEMSGYHGCSKKALVFLLKFLSDLVPFEPPQ 318
                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 66880553    488 YLQVHILHPPLVPGKYRSLLTDYISLAKTRLADLKVS 524
Cdd:pfam15865  319 YLKVHILHPPLVPGKYRSLLQDYKTLAKTRLADLKVS 355
Fanconi_A pfam03511
Fanconi anaemia group A protein;
1266-1312 6.05e-19

Fanconi anaemia group A protein;


Pssm-ID: 460952  Cd Length: 63  Bit Score: 82.05  E-value: 6.05e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 66880553   1266 MGLLSSHLTSNSTTDLPKAFHVCAAILECLEKRKISWLALFQLTESD 1312
Cdd:pfam03511   13 MGLLSSHLTPKEAVDSLKALDVCAEILGCLEKRKVSWLVLFQLTETD 59
 
Name Accession Description Interval E-value
Fanconi_A_N pfam15865
Fanconi anaemia group A protein N terminus;
170-524 0e+00

Fanconi anaemia group A protein N terminus;


Pssm-ID: 464911  Cd Length: 355  Bit Score: 595.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    170 LWKI--QSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLCEQMEASCQHADVARAMLSDFVQMFVLRGf 247
Cdd:pfam15865    1 LWRIleQQCLLLEVVWQLHVLNILTLTELLESHEDSQALQVWLFRFLCLLCEQIEASCQHTETERALLSDFVQMFVLRG- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    248 qKNSDLRRTVEPEKMPQVTVDVLQRMLIFALDALAAGVQEESSTHKIVRCWFGVFSGHTLGSVISTDPLKRFFSHTLTQI 327
Cdd:pfam15865   80 -KNSDLRRAAEDEKMPQVLTAVLQRMLSFLLDALAANPQEESLAYKAVRCWFGVFSGSTLCSSLSDDALKRFFSHTLTQL 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    328 LTHSPVLKASDAVQMQREWSFARTHPLLTSLYRRLFVMLSAEELVGHLQEVLETQEVHWQRVLSFVSALVVCFPEAQQLL 407
Cdd:pfam15865  159 LTLHPVLKVSDAIQMQSEWSFARTDELLTTLYRRLFVKLSPEELLGHLQEVLETHEVNWKHVLSCVSTLVVCAPEAQQLI 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66880553    408 EDWVARLMAQAFESCQLDSMVTAFLVVRQAALEGPSAFLSYADWFKASFGSTRGYHGCSKKALVFLFTFLSELVPFESPR 487
Cdd:pfam15865  239 KDWLKRLLARAFESGDLDSMVTAFLTARQAALEGPNVFPSYADWFKQSFGEMSGYHGCSKKALVFLLKFLSDLVPFEPPQ 318
                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 66880553    488 YLQVHILHPPLVPGKYRSLLTDYISLAKTRLADLKVS 524
Cdd:pfam15865  319 YLKVHILHPPLVPGKYRSLLQDYKTLAKTRLADLKVS 355
Fanconi_A pfam03511
Fanconi anaemia group A protein;
1266-1312 6.05e-19

Fanconi anaemia group A protein;


Pssm-ID: 460952  Cd Length: 63  Bit Score: 82.05  E-value: 6.05e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 66880553   1266 MGLLSSHLTSNSTTDLPKAFHVCAAILECLEKRKISWLALFQLTESD 1312
Cdd:pfam03511   13 MGLLSSHLTPKEAVDSLKALDVCAEILGCLEKRKVSWLVLFQLTETD 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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