NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|108773801|ref|NP_000161|]
View 

glycine dehydrogenase (decarboxylating), mitochondrial precursor [Homo sapiens]

Protein Classification

aminomethyl-transferring glycine dehydrogenase( domain architecture ID 1004953)

aminomethyl-transferring glycine dehydrogenase is part of the glycine cleavage system that catalyzes the degradation of glycine

EC:  1.4.4.2
PubMed:  4585091

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02414 super family cl31876
glycine dehydrogenase (decarboxylating)
 51-1009 0e+00

glycine dehydrogenase (decarboxylating)


The actual alignment was detected with superfamily member PLN02414:

Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1480.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   51 RLLERLLPRH------------DDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRlKRPLKME---DPVCENE 115
Cdd:PLN02414   11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLSkydEGLTESQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  116 ILATLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANAS 195
Cdd:PLN02414   90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  196 LLDEGTAAAEALQLCYRHNKRRK--FLVDPRCHPQTIAVVQTRAKYTG---VLTELKlpcEMDFSGKDVSGVLFQYPDTE 270
Cdd:PLN02414  170 LLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGlevVVADEK---DFDYSSGDVCGVLVQYPATD 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  271 GKVEDFTELVERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVG 350
Cdd:PLN02414  247 GEVLDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIG 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  351 VTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQ 430
Cdd:PLN02414  327 VSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQ 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  431 HDLFFDTLKIQCGcSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEECRGIPG 510
Cdd:PLN02414  407 SLPFFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIP 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  511 SVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQG 590
Cdd:PLN02414  486 SSLARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQG 565

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  591 YQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEV 670
Cdd:PLN02414  566 YQEMFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGT 645

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  671 DKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHL 750
Cdd:PLN02414  646 DAKGNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHL 725

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  751 NLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVI---SLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLK 827
Cdd:PLN02414  726 NLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLT 805

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  828 QATETAILNANYMAKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEP 907
Cdd:PLN02414  806 DASKIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEP 885

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  908 TESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTIA 987
Cdd:PLN02414  886 TESESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTG 964

                         970       980
                  ....*....|....*....|..
gi 108773801  988 RIDDIYGDQHLVCTCPPMEVYE 1009
Cdd:PLN02414  965 RVDNVYGDRNLVCTLPSAAEEE 986
 
Name Accession Description Interval E-value
PLN02414 PLN02414
glycine dehydrogenase (decarboxylating)
 51-1009 0e+00

glycine dehydrogenase (decarboxylating)


Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1480.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   51 RLLERLLPRH------------DDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRlKRPLKME---DPVCENE 115
Cdd:PLN02414   11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLSkydEGLTESQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  116 ILATLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANAS 195
Cdd:PLN02414   90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  196 LLDEGTAAAEALQLCYRHNKRRK--FLVDPRCHPQTIAVVQTRAKYTG---VLTELKlpcEMDFSGKDVSGVLFQYPDTE 270
Cdd:PLN02414  170 LLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGlevVVADEK---DFDYSSGDVCGVLVQYPATD 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  271 GKVEDFTELVERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVG 350
Cdd:PLN02414  247 GEVLDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIG 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  351 VTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQ 430
Cdd:PLN02414  327 VSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQ 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  431 HDLFFDTLKIQCGcSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEECRGIPG 510
Cdd:PLN02414  407 SLPFFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIP 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  511 SVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQG 590
Cdd:PLN02414  486 SSLARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQG 565

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  591 YQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEV 670
Cdd:PLN02414  566 YQEMFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGT 645

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  671 DKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHL 750
Cdd:PLN02414  646 DAKGNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHL 725

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  751 NLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVI---SLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLK 827
Cdd:PLN02414  726 NLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLT 805

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  828 QATETAILNANYMAKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEP 907
Cdd:PLN02414  806 DASKIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEP 885

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  908 TESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTIA 987
Cdd:PLN02414  886 TESESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTG 964

                         970       980
                  ....*....|....*....|..
gi 108773801  988 RIDDIYGDQHLVCTCPPMEVYE 1009
Cdd:PLN02414  965 RVDNVYGDRNLVCTLPSAAEEE 986
gcvP TIGR00461
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ...
 66-1002 0e+00

glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273089 [Multi-domain]  Cd Length: 939  Bit Score: 1309.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801    66 RHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVPQ 145
Cdd:TIGR00461    1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   146 TILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRR--KFLVDP 223
Cdd:TIGR00461   81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKanAFFVAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   224 RCHPQTIAVVQTRAKYTGVltELKLPCEMDFS-GKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCIL 302
Cdd:TIGR00461  161 DCHPQTIEVIKTRANPFGI--EVIVGDHHTFSfSTDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   303 RPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNIC 382
Cdd:TIGR00461  239 TPPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNIC 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   383 TAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINFR 461
Cdd:TIGR00461  319 TAQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGeQSAPAILKAAEGRGINLR 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   462 LFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKL 541
Cdd:TIGR00461  399 PLVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQL 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   542 ENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQG 621
Cdd:TIGR00461  479 ESKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQG 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   622 EYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPS 701
Cdd:TIGR00461  559 EYAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPS 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   702 TNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLP 781
Cdd:TIGR00461  639 THGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLP 718

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   782 NHPVISLKRNE-DACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYMAKRLETHYRILFRGARGYVG 860
Cdd:TIGR00461  719 RHSLNSTAELQgEDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVA 798

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   861 HEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDP 940
Cdd:TIGR00461  799 HECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDP 878

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 108773801   941 RVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTIARIDDIYGDQHLVCTC 1002
Cdd:TIGR00461  879 ADNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
GDC-P pfam02347
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ...
 65-488 0e+00

Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2


Pssm-ID: 396772 [Multi-domain]  Cd Length: 428  Bit Score: 782.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801    65 RRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVP 144
Cdd:pfam02347    1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   145 QTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRR--KFLVD 222
Cdd:pfam02347   81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   223 PRCHPQTIAVVQTRAKYTGVLTELKLPCEMDFSG-KDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCI 301
Cdd:pfam02347  161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTDlKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   302 LRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNI 381
Cdd:pfam02347  241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   382 CTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINF 460
Cdd:pfam02347  321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400

                          410       420
                   ....*....|....*....|....*...
gi 108773801   461 RLFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:pfam02347  401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
GcvP2 COG1003
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ...
 508-1001 0e+00

Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440627  Cd Length: 468  Bit Score: 732.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  508 IPGSvFKRTSPflthqVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQ 587
Cdd:COG1003    14 LPEA-LLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPFQPEET 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  588 AQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQP 667
Cdd:COG1003    88 VQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAGFKVVV 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  668 VEVDKYGNIDAVHLKAMVDkhkENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDV 747
Cdd:COG1003   168 VKSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGDMGFDV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  748 SHLNLHKTFCIphggggpgmgpigVKKHLAPFLPNHPVI----SLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGG 823
Cdd:COG1003   245 CHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVkdgdKYRLDYDRPKSIGRSAAFYGNAGVLVRAYAYIRMMGA 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  824 KGLKQATETAILNANYMAKRLETHYRILFRGaRGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWP--VAG 901
Cdd:COG1003   325 EGLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYFPliVPE 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  902 TLMVEPTESEDKAELDRFCDAMISIRQEIADieegriDPrvNPLKMSPHSLtcvtsshwdrpysrevaafplpfvkpenk 981
Cdd:COG1003   404 TLMIEPTESESKEELDRFIDAMIAIREEARE------DP--EPLKNAPHTT----------------------------- 446

                         490       500
                  ....*....|....*....|
gi 108773801  982 fwpTIARIDDIYGDQHLVCT 1001
Cdd:COG1003   447 ---PVRRLDEVYADRNLVLT 463
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 113-488 2.93e-175

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 516.40  E-value: 2.93e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  113 ENEILATLHAISSKNQIWR---SYIGMGYYNCSVPQTILRNLLENsGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGL 189
Cdd:cd00613     1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  190 DMANASLLDEGTAAAEALQLCYRHNK--RRKFLVDPRCHPQTIAVVQTRAKYTGVLTELKLPCEM---------DFSGKD 258
Cdd:cd00613    80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  259 VSGVLFQYPDTEGKVEDF-TELVERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVR 337
Cdd:cd00613   160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  338 ESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLI 417
Cdd:cd00613   240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108773801  418 LSEGLKRAGHQLQ-HDLFFDTLKIQCGC---SVKEVLGRAAQRQINFR----LFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:cd00613   320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPlygIRAEDLAKALIDGGFHAptmyLPVDGTLMIEPTETETKEELDALLEAL 398
 
Name Accession Description Interval E-value
PLN02414 PLN02414
glycine dehydrogenase (decarboxylating)
 51-1009 0e+00

glycine dehydrogenase (decarboxylating)


Pssm-ID: 178035 [Multi-domain]  Cd Length: 993  Bit Score: 1480.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   51 RLLERLLPRH------------DDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRlKRPLKME---DPVCENE 115
Cdd:PLN02414   11 GLLRRLVNEQtrsisvealkpsDTFPRRHNSATPEEQKAMAEYCGFDSLDALIDATVPKSIR-LDSMKLSkydEGLTESQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  116 ILATLHAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANAS 195
Cdd:PLN02414   90 MLEHMKSLASKNKVFKSYIGMGYYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNAS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  196 LLDEGTAAAEALQLCYRHNKRRK--FLVDPRCHPQTIAVVQTRAKYTG---VLTELKlpcEMDFSGKDVSGVLFQYPDTE 270
Cdd:PLN02414  170 LLDEGTAAAEAMAMCNNILKGKKkkFLIASNCHPQTIDVCQTRADGLGlevVVADEK---DFDYSSGDVCGVLVQYPATD 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  271 GKVEDFTELVERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVG 350
Cdd:PLN02414  247 GEVLDYAEFVKNAHANGVKVVMATDLLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIG 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  351 VTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQ 430
Cdd:PLN02414  327 VSVDSSGKPALRMAMQTREQHIRRDKATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQ 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  431 HDLFFDTLKIQCGcSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEECRGIPG 510
Cdd:PLN02414  407 SLPFFDTVKVKCS-DADAIADAAAKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFTAESLAPEVDSSIP 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  511 SVFKRTSPFLTHQVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQG 590
Cdd:PLN02414  486 SSLARESPYLTHPIFNQYHSEHELLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQG 565

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  591 YQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEV 670
Cdd:PLN02414  566 YQEMFEDLGDLLCEITGFDSFSLQPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGT 645

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  671 DKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHL 750
Cdd:PLN02414  646 DAKGNINIEELRKAAEAHKDNLAALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHL 725

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  751 NLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPNHPVI---SLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLK 827
Cdd:PLN02414  726 NLHKTFCIPHGGGGPGMGPIGVKKHLAPFLPSHPVVptgGIPRPEKTQPLGTISAAPWGSALILPISYTYIAMMGSEGLT 805

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  828 QATETAILNANYMAKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEP 907
Cdd:PLN02414  806 DASKIAILNANYMAKRLEGHYPVLFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEP 885

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  908 TESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTIA 987
Cdd:PLN02414  886 TESESKAELDRFCDALISIREEIADIENGKADRENNVLKGAPHPPSLLMADKWDKPYSREYAAFPAPWVR-ASKFWPTTG 964

                         970       980
                  ....*....|....*....|..
gi 108773801  988 RIDDIYGDQHLVCTCPPMEVYE 1009
Cdd:PLN02414  965 RVDNVYGDRNLVCTLPSAAEEE 986
gcvP TIGR00461
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ...
 66-1002 0e+00

glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273089 [Multi-domain]  Cd Length: 939  Bit Score: 1309.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801    66 RHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVPQ 145
Cdd:TIGR00461    1 RHLGPGETEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   146 TILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRR--KFLVDP 223
Cdd:TIGR00461   81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKanAFFVAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   224 RCHPQTIAVVQTRAKYTGVltELKLPCEMDFS-GKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCIL 302
Cdd:TIGR00461  161 DCHPQTIEVIKTRANPFGI--EVIVGDHHTFSfSTDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   303 RPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNIC 382
Cdd:TIGR00461  239 TPPGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNIC 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   383 TAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINFR 461
Cdd:TIGR00461  319 TAQVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGeQSAPAILKAAEGRGINLR 398

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   462 LFEDGTLGISLDETVNEKDLDDLLWIFGCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKKL 541
Cdd:TIGR00461  399 PLVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTPEELWSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQL 478

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   542 ENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQG 621
Cdd:TIGR00461  479 ESKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQG 558

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   622 EYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPS 701
Cdd:TIGR00461  559 EYAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPS 638

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   702 TNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFLP 781
Cdd:TIGR00461  639 THGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLP 718

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   782 NHPVISLKRNE-DACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYMAKRLETHYRILFRGARGYVG 860
Cdd:TIGR00461  719 RHSLNSTAELQgEDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVA 798

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   861 HEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVAGTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDP 940
Cdd:TIGR00461  799 HECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDP 878

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 108773801   941 RVNPLKMSPHSLTCVTSSHWDRPYSREVAAFPLPFVKpENKFWPTIARIDDIYGDQHLVCTC 1002
Cdd:TIGR00461  879 ADNPLKNAPHTAQSLICGEWNHPYSREEAAYPAPWTK-QFKFWPTVGRLDDTYGDRNLVCSC 939
GDC-P pfam02347
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ...
 65-488 0e+00

Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2


Pssm-ID: 396772 [Multi-domain]  Cd Length: 428  Bit Score: 782.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801    65 RRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYNCSVP 144
Cdd:pfam02347    1 DRHIGPSEKDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   145 QTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRR--KFLVD 222
Cdd:pfam02347   81 PVILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKgkKFVVD 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   223 PRCHPQTIAVVQTRAKYTGVLTELKLPCEMDFSG-KDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALCI 301
Cdd:pfam02347  161 KDVHPQTLEVLKTRAKPFGIEIVEVDYTEEGVTDlKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTL 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   302 LRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNI 381
Cdd:pfam02347  241 LKPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNI 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   382 CTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDLFFDTLKIQCG-CSVKEVLGRAAQRQINF 460
Cdd:pfam02347  321 CTAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEdKAVEEVLARAEARGINL 400

                          410       420
                   ....*....|....*....|....*...
gi 108773801   461 RLFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:pfam02347  401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
GcvP2 COG1003
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ...
 508-1001 0e+00

Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440627  Cd Length: 468  Bit Score: 732.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  508 IPGSvFKRTSPflthqVFNSYHSETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQ 587
Cdd:COG1003    14 LPEA-LLRKSP-----VFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHPFQPEET 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  588 AQGYQQLFRELEKDLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQP 667
Cdd:COG1003    88 VQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMAGFKVVV 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  668 VEVDKYGNIDAVHLKAMVDkhkENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDV 747
Cdd:COG1003   168 VKSDEDGNVDLEDLKAKVG---DRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPGDMGFDV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  748 SHLNLHKTFCIphggggpgmgpigVKKHLAPFLPNHPVI----SLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGG 823
Cdd:COG1003   245 CHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVkdgdKYRLDYDRPKSIGRSAAFYGNAGVLVRAYAYIRMMGA 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  824 KGLKQATETAILNANYMAKRLETHYRILFRGaRGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWP--VAG 901
Cdd:COG1003   325 EGLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYFPliVPE 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  902 TLMVEPTESEDKAELDRFCDAMISIRQEIADieegriDPrvNPLKMSPHSLtcvtsshwdrpysrevaafplpfvkpenk 981
Cdd:COG1003   404 TLMIEPTESESKEELDRFIDAMIAIREEARE------DP--EPLKNAPHTT----------------------------- 446

                         490       500
                  ....*....|....*....|
gi 108773801  982 fwpTIARIDDIYGDQHLVCT 1001
Cdd:COG1003   447 ---PVRRLDEVYADRNLVLT 463
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 61-489 0e+00

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 650.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   61 DDFARRHIGPGDKDQREMLQTLGLASIDELIEKtVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWRSYIGMGYYN 140
Cdd:COG0403     1 DEFAMRYIPPTEEDRAEMLAAIGVDSLDELFDD-IPAEIRLKRPLDLPEALSEAELLRHLRALAAKNKVLTSFIGAGYYD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  141 CSVPQTIlRNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKR-RKF 219
Cdd:COG0403    80 HYVPAVV-RNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTKRsNKV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  220 LVDPRCHPQTIAVVQTRAKYTGV-LTELKLP-CEMDFS------GKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLAC 291
Cdd:COG0403   159 LVSEDVHPQTRAVLKTYAEPLGIeVVEVPDEdGVTDLEalkallDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALVI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  292 CATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQH 371
Cdd:COG0403   239 VAADPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQH 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  372 IRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQ-HDLFFDTLKIQCGCSVKEVL 450
Cdd:COG0403   319 IRREKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALGVEVPfNGPFFDEFVVRLPKPAAEIN 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 108773801  451 GRAAQRQI----NFRLFEDGTLGISLDETVNEKDLDDLLWIFG 489
Cdd:COG0403   399 AALLEKGIlgglNLRRVDDDTLLVAVTETTTKEDIDALVEALA 441
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 113-488 2.93e-175

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 516.40  E-value: 2.93e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  113 ENEILATLHAISSKNQIWR---SYIGMGYYNCSVPQTILRNLLENsGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGL 189
Cdd:cd00613     1 ETEVLRHLKRLASKNKALDqsmSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  190 DMANASLLDEGTAAAEALQLCYRHNK--RRKFLVDPRCHPQTIAVVQTRAKYTGVLTELKLPCEM---------DFSGKD 258
Cdd:cd00613    80 DVANASLQDEATAAAEAAGLAAIRAYhkRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDEGgtvdlealkEEVSEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  259 VSGVLFQYPDTEGKVEDF-TELVERAHQSGSLACCATDLLALCILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVR 337
Cdd:cd00613   160 VAALMVQYPNTLGVFEDLiKEIADIAHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  338 ESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLI 417
Cdd:cd00613   240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108773801  418 LSEGLKRAGHQLQ-HDLFFDTLKIQCGC---SVKEVLGRAAQRQINFR----LFEDGTLGISLDETVNEKDLDDLLWIF 488
Cdd:cd00613   320 LAKRLKEVGGVLPfNGPFFHEFVLRLPPlygIRAEDLAKALIDGGFHAptmyLPVDGTLMIEPTETETKEELDALLEAL 398
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 531-923 7.91e-160

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 476.72  E-value: 7.91e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  531 ETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNSSSELAPITWK-EFANIHPFVPLDQAQGYQQLFRELEKDLCELTGYD 609
Cdd:cd00613     1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILEnEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  610 --QVCFQPNSGAQGEYAGLATIRAYlnqkgeGHRTVCLIPKSAHGTNPASAHMA----GMKIQPVEVDKYGNIDavhLKA 683
Cdd:cd00613    81 vaNASLQDEATAAAEAAGLAAIRAY------HKRNKVLVPDSAHPTNPAVARTRgeplGIEVVEVPSDEGGTVD---LEA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  684 MVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQvGICRPGDFGSDVSHLNLHKTF------- 756
Cdd:cd00613   152 LKEEVSEEVAALMVQYPNTLGVFEDLIKEIADIAHSAGALVYVDGDNLNLT-GLKPPGEYGADIVVGNLQKTGvphgggg 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  757 ------CiphggggpgmgpigVKKHLAPFLPNHPVISLKrNEDACPVGTVSAA---------------PWGSSSILPISW 815
Cdd:cd00613   231 pgagffA--------------VKKELVRFLPGRLVGVTK-DAEGNRAFRLALQtreqhirrekatsniCTGQALLALMAA 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  816 AYIKMMGGKGLKQATETAILNANYMAKRLETHYRILfrGARGYVGHEFILDTRPFkksANIEAVDVAKRLQDYGFHAPTM 895
Cdd:cd00613   296 MYIVYLGPEGLKEIAERAHLNANYLAKRLKEVGGVL--PFNGPFFHEFVLRLPPL---YGIRAEDLAKALIDGGFHAPTM 370

                         410       420
                  ....*....|....*....|....*...
gi 108773801  896 SWPVAGTLMVEPTESEDKAELDRFCDAM 923
Cdd:cd00613   371 YLPVDGTLMIEPTETETKEELDALLEAL 398
PRK04366 PRK04366
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
530-953 1.47e-141

aminomethyl-transferring glycine dehydrogenase subunit GcvPB;


Pssm-ID: 235292  Cd Length: 481  Bit Score: 432.61  E-value: 1.47e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  530 SETNIVRYMKKLENKDISLVHSMIPLGSCTMKLNssselaP-ITWK-----EFANIHPFVPLDQAQGYQQLFRELEKDLC 603
Cdd:PRK04366   50 SELEVVRHYTRLSQKNYGVDTGFYPLGSCTMKYN------PkINEKvarlpGFAELHPLQPEETVQGALELMYELQEWLK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  604 ELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKA 683
Cdd:PRK04366  124 EITGMDAVTLQPAAGAHGELTGLLMIRAYHEARGDTKRTEVIVPDSAHGTNPASAAMAGFKVVEIPSNEDGLVDLEALKA 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  684 MVDkhkENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGG 763
Cdd:PRK04366  204 AVG---EDTAALMLTNPNTLGLFERNILEIAEIVHEAGGLLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFSTPHGGG 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  764 GPGMGPIGVKKHLAPFLPnHPVIslKRNEDA------CP--VGTVSAApWGSSSILPISWAYIKMMGGKGLKQATETAIL 835
Cdd:PRK04366  281 GPGSGPVGVKEELAPFLP-VPVV--EKDGDRyrldydRPksIGRVRAF-YGNFGVLVRAYAYIRSLGAEGLREVSEDAVL 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  836 NANYMAKRLETHYRILFRGARgyvGHEFILDTRPFKKSaNIEAVDVAKRLQDYGFHAPTMSWP--VAGTLMVEPTESEDK 913
Cdd:PRK04366  357 NANYLKARLKDIYDLPYDRPC---MHEFVLSGKKLKET-GVRTLDIAKRLLDYGFHPPTIYFPliVPEALMIEPTETESK 432

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 108773801  914 AELDRFCDAMISIRqeiadiEEGRIDPRVnpLKMSPHSLT 953
Cdd:PRK04366  433 ETLDAFIAAMKQIA------EEAKENPEL--VKEAPHNTP 464
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
72-458 1.12e-121

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 379.10  E-value: 1.12e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   72 DKDQREMLQTLGLASIDELIEKtVPANIRLKRPLKMEDPVCENEILATLHAISSKNQIWR---SYIGMGYYNCSVPqTIL 148
Cdd:PRK00451    9 EEDIREMLDAIGVKSIDELFAD-IPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEeypSFLGAGAYDHYIP-AVV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  149 RNLLENSGWITQYTPYQPEVSQGRLESLLNYQTMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQ 228
Cdd:PRK00451   87 DHIISRSEFYTAYTPYQPEISQGTLQAIFEYQTMICELTGMDVANASMYDGATALAEAALMAVRITKRKKVLVSGAVHPE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  229 TIAVVQTRAKYTGV-LTELKL-PCEMDFS------GKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALC 300
Cdd:PRK00451  167 YREVLKTYLKGQGIeVVEVPYeDGVTDLEaleaavDDDTAAVVVQYPNFFGVIEDLEEIAEIAHAGGALFIVGVDPVSLG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  301 ILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEVYRLALQTREQHIRRDKATSN 380
Cdd:PRK00451  247 LLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHIRREKATSN 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 108773801  381 ICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSEGLKRAGHQLQHDL-FFDTLKIQCGCSVKEVLGRAAQRQI 458
Cdd:PRK00451  327 ICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEIGGVELFDGpFFNEFVVRLPKPAEEVNEALLEKGI 405
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 597-757 1.68e-11

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 63.56  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  597 ELEKDLCELT--GYDQVCFQPnSGAQGEYAGLATIRAYlnqkgeghRTVCLIPKSAHGTNPAS-AHMAGMKIQPVEVDKY 673
Cdd:cd01494     4 ELEEKLARLLqpGNDKAVFVP-SGTGANEAALLALLGP--------GDEVIVDANGHGSRYWVaAELAGAKPVPVPVDDA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  674 GNIDAvHLKAMVD-KHKENLAAIMITYPSTNGVFEENISDVCDLIHQHGGQVYLDGANMNAQVGI--CRPGDFGSDVSHL 750
Cdd:cd01494    75 GYGGL-DVAILEElKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPApgVLIPEGGADVVTF 153


                  ....*..
gi 108773801  751 NLHKTFC 757
Cdd:cd01494   154 SLHKNLG 160
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
586-729 4.98e-06

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 49.52  E-value: 4.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801   586 DQAQGYQQLFRELEKDLCELTGYDQVCFQPnSGAQGEYAGLATirayLNQKGEGhrTVCLIPksAHG---TNPASAHMAG 662
Cdd:pfam01212   25 DEVYGGDPTVNRLEDRVAELFGKEAALFVP-SGTAANQLALMA----HCQRGDE--VICGEP--AHIhfdETGGHAELGG 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 108773801   663 MKIQPVEVDKYGNIDAVHLKAMVDKHK----ENLAAIMITypSTNG------VFEENISDVCDLIHQHGGQVYLDGA 729
Cdd:pfam01212   96 VQPRPLDGDEAGNMDLEDLEAAIREVGadifPPTGLISLE--NTHNsaggqvVSLENLREIAALAREHGIPVHLDGA 170
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 658-747 8.28e-05

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 46.18  E-value: 8.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  658 AHMAGMKIqpVEV-DKYGNIDAVHLKAMVDkhkENLAAIMITYPSTNGVFEEnISDVCDLIHQHGGQVYLdGANMNAQVG 736
Cdd:COG0403   176 AEPLGIEV--VEVpDEDGVTDLEALKALLD---DDVAGVLVQYPNFFGVIED-LRAIAEAAHAAGALVIV-AADPLSLGL 248

                          90
                  ....*....|.
gi 108773801  737 ICRPGDFGSDV 747
Cdd:COG0403   249 LKPPGELGADI 259
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
817-923 2.03e-04

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 45.13  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  817 YIKMMGGKGLKQATETAILNANYMAKRLETH-YRILFRGArgyVGHEFILDTrpfkksaNIEAVDVAKRLQDYGFHA--- 892
Cdd:PRK00451  341 YMSLLGPEGLRELAEQNHQKAHYLAERLAEIgGVELFDGP---FFNEFVVRL-------PKPAEEVNEALLEKGILGgyd 410

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 108773801  893 -----PTMswpvAGTLMVEPTESEDKAELDRFCDAM 923
Cdd:PRK00451  411 lgryyPEL----GNHLLVCVTEKRTKEDIDALVAAL 442
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 623-729 2.42e-04

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 44.50  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  623 YAGLAT-IRAYLNQKGEGHRT----VCLIPKSAHGTNPASAHMAGMKIQPVEVDKYGNIDAVHLKAMVDKHK-ENLAAIM 696
Cdd:cd06450    72 LALLAArDRARKRLKAGGGRGidklVIVCSDQAHVSVEKAAAYLDVKVRLVPVDEDGRMDPEALEAAIDEDKaEGLNPIM 151

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 108773801  697 I--TYPSTN-GVFeENISDVCDLIHQHGGQVYLDGA 729
Cdd:cd06450   152 VvaTAGTTDtGAI-DPLEEIADLAEKYDLWLHVDAA 186
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 821-923 9.68e-04

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 42.71  E-value: 9.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  821 MGGKGLKQATETAILNANYMAKRL-ETHYRILFRGArgyVGHEFILDTrpfkksaNIEAVDVAKRLQDYGFHAPT-MSWP 898
Cdd:COG0403   346 HGPEGLKEIAERIHQKAHYLAERLaALGVEVPFNGP---FFDEFVVRL-------PKPAAEINAALLEKGILGGLnLRRV 415

                          90       100
                  ....*....|....*....|....*
gi 108773801  899 VAGTLMVEPTESEDKAELDRFCDAM 923
Cdd:COG0403   416 DDDTLLVAVTETTTKEDIDALVEAL 440
TA_like cd06502
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ...
 586-729 2.30e-03

Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.


Pssm-ID: 99748 [Multi-domain]  Cd Length: 338  Bit Score: 41.55  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  586 DQAQGYQQLFRELEKDLCELTGYDQVCFQPNsgaqGEYAGLATIRAYLNQkgeGHRTVCliPKSAHGTNP---ASAHMAG 662
Cdd:cd06502    25 DDVYGEDPTTAKLEARAAELFGKEAALFVPS----GTAANQLALAAHTQP---GGSVIC--HETAHIYTDeagAPEFLSG 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 108773801  663 MKIQPVE-VDKYGNIDAV--HLKAMVDKHKENLAAIMITyPSTNG---VFEENISDVCDLIHQHGGQVYLDGA 729
Cdd:cd06502    96 VKLLPVPgENGKLTPEDLeaAIRPRDDIHFPPPSLVSLE-NTTEGgtvYPLDELKAISALAKENGLPLHLDGA 167
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
588-747 2.70e-03

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 41.28  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  588 AQG-YQQLFrELEKDLCELTGYDQVcfqpNS----GAQ--GEYAGLAtIRAylnqkgEGHRTVcLIPKSAHgtnPAS--- 657
Cdd:PRK00451  107 SQGtLQAIF-EYQTMICELTGMDVA----NAsmydGATalAEAALMA-VRI------TKRKKV-LVSGAVH---PEYrev 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 108773801  658 ----AHMAGMKIQPVEVDKyGNIDAVHLKAMVDkhkENLAAIMITYPSTNGVFEEnISDVCDLIHQHGGQVYLdGANMNA 733
Cdd:PRK00451  171 lktyLKGQGIEVVEVPYED-GVTDLEALEAAVD---DDTAAVVVQYPNFFGVIED-LEEIAEIAHAGGALFIV-GVDPVS 244

                         170
                  ....*....|....
gi 108773801  734 QVGICRPGDFGSDV 747
Cdd:PRK00451  245 LGLLKPPGEYGADI 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH