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Conserved domains on  [gi|48762689|ref|NP_001001486|]
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calcium-transporting ATPase type 2C member 1 isoform 1d [Homo sapiens]

Protein Classification

calcium-transporting ATPase type 2C( domain architecture ID 11550604)

calcium-transporting ATPase type 2C is an ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
54-896 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1586.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  54 RRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSK 133
Cdd:cd02085   1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 134 LVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213
Cdd:cd02085  81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILE 293
Cdd:cd02085 161 SNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLE 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 294 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglha 373
Cdd:cd02085 241 MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------ 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 374 evtgvgynqfgevivdgdvvhgfynpavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYP 453
Cdd:cd02085 315 ----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIP 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 454 FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPE 532
Cdd:cd02085 361 FSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPE 440
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 533 LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVP 612
Cdd:cd02085 441 LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVR 520
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 613 KVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd02085 521 KVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEG 600
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILT 772
Cdd:cd02085 601 KGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILT 680
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 773 KNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSI 852
Cdd:cd02085 681 RSLILNVLLSAAIIVSGTLWVFWKEMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSL 760
                       810       820       830       840
                ....*....|....*....|....*....|....*....|....
gi 48762689 853 MGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02085 761 IGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
54-896 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1586.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  54 RRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSK 133
Cdd:cd02085   1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 134 LVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213
Cdd:cd02085  81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILE 293
Cdd:cd02085 161 SNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLE 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 294 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglha 373
Cdd:cd02085 241 MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------ 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 374 evtgvgynqfgevivdgdvvhgfynpavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYP 453
Cdd:cd02085 315 ----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIP 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 454 FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPE 532
Cdd:cd02085 361 FSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPE 440
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 533 LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVP 612
Cdd:cd02085 441 LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVR 520
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 613 KVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd02085 521 KVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEG 600
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILT 772
Cdd:cd02085 601 KGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILT 680
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 773 KNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSI 852
Cdd:cd02085 681 RSLILNVLLSAAIIVSGTLWVFWKEMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSL 760
                       810       820       830       840
                ....*....|....*....|....*....|....*....|....
gi 48762689 853 MGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02085 761 IGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
23-903 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1584.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    23 SKKASELPVSEVASILQADLQNGLN-KCEVSHRRAFHGWNEFDISEDEPLWKKYISQF-KNPLIMLLLASAVISVLMHQF 100
Cdd:TIGR01522   1 SKQYCELSVEETCSKLQTDLQNGLNsSQEASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   101 DDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD 180
Cdd:TIGR01522  81 DDAVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   181 LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQK 260
Cdd:TIGR01522 161 LSIDESNLTGETTPVSKVTAPIPAATNGDLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   261 SMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:TIGR01522 241 SMDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVET 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   341 LGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNN- 419
Cdd:TIGR01522 321 LGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNEa 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   420 -TLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRtqQDRPEICFMKGAYEQVIKYCTTYQSK-G 497
Cdd:TIGR01522 401 dTLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHR--QDRSEMCFMKGAYEQVLKYCTYYQKKdG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   498 QTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 577
Cdd:TIGR01522 479 KTLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETA 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   578 VAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 657
Cdd:TIGR01522 559 VSIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   658 GVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWI 737
Cdd:TIGR01522 639 GVAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWI 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   738 NIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVF 817
Cdd:TIGR01522 719 NILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVITARDTTMTFTCFVF 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   818 FDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKK 897
Cdd:TIGR01522 799 FDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRKK 878

                  ....*.
gi 48762689   898 VERSRE 903
Cdd:TIGR01522 879 VERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
22-904 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 1017.73  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  22 TSKKASELPVSEVASILQADlQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFD 101
Cdd:COG0474   4 ALKDWHALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLGDWV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 102 DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDL 181
Cdd:COG0474  83 DAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 182 SIDESSLTGETTPCSKVTAPQPAATNgdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKS 261
Cdd:COG0474 163 QVDESALTGESVPVEKSADPLPEDAP--LGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEKTPLQKQ 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 262 MDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETL 341
Cdd:COG0474 241 LDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETL 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 342 GCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAevtgvgynqfgevivdgdvVHGFYNPAVSRIVEAGCVCNDAVIRNNTL 421
Cdd:COG0474 321 GSVTVICTDKTGTLTQNKMTVERVYTGGGTYE-------------------VTGEFDPALEELLRAAALCSDAQLEEETG 381
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 422 MGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPeICFMKGAYEQVIKYCTTYQSKGQT 499
Cdd:COG0474 382 LGDPTEGALLVAAAKAGLDveELRKEYPRVDEIPFDSERKRMST--VHEDPDGKR-LLIVKGAPEVVLALCTRVLTGGGV 458
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 500 LTLTQQQRDVYQQEKARMGSAGLRVLALA-----SGPEL------GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKM 568
Cdd:COG0474 459 VPLTEEDRAEILEAVEELAAQGLRVLAVAykelpADPELdseddeSDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKM 538
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 569 ITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVND 648
Cdd:COG0474 539 ITGDHPATARAIARQLGLGDDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVND 618
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 649 AVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNP 728
Cdd:COG0474 619 APALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLP 698
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 729 LNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDT 808
Cdd:COG0474 699 LTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALARGASLALAR 778
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 809 TMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSV 888
Cdd:COG0474 779 TMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLY 858
                       890
                ....*....|....*.
gi 48762689 889 CIVAEIIKKVERSREK 904
Cdd:COG0474 859 LLLVELVKLLRRRFGR 874
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
18-794 3.93e-104

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 345.13  E-value: 3.93e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   18 IPVLTSKKASELPVSEVASILQA--DLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV 95
Cdd:PRK10517  38 VPPSLSARCLKAAVMPEEELWKTfdTHPEGLNEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISY 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   96 LMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR--EGKLEHTLA----RDLVPGDTVCLSVGDRV 169
Cdd:PRK10517 118 ATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRviNDKGENGWLeipiDQLVPGDIIKLAAGDMI 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  170 PADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQ 249
Cdd:PRK10517 198 PADLRILQARDLFVAQASLTGESLPVEKFATTRQPEHSNPL-ECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVS 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  250 AEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV-GWLLGkDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:PRK10517 277 EQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLInGYTKG-DWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQ 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  329 RAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthIFTSDglHAEVtgvgynqFGEviVDGDVVH-----GFYNPAVSR 403
Cdd:PRK10517 356 KVIVKRLDAIQNFGAMDILCTDKTGTLTQDK-----IVLEN--HTDI-------SGK--TSERVLHsawlnSHYQTGLKN 419
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  404 IVEAgcvcndAVIrnntlmgkptEGALIALAMKMGldglqQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPE-ICfmKGA 482
Cdd:PRK10517 420 LLDT------AVL----------EGVDEESARSLA-----SRWQKIDEIPFDFERRRMSV--VVAENTEHHQlIC--KGA 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  483 YEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELGQLTFLGLVGIIDPPRTG 551
Cdd:PRK10517 475 LEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYlparegdyqraDESDLILEGYIAFLDPPKET 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  552 VKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKS 631
Cdd:PRK10517 555 TAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTL 632
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  632 LQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSI 711
Cdd:PRK10517 633 LKREGHVVGFMGDGINDAPALRAADIGISV-DGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNF 711
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  712 AAL--TLISLATLmnfPN-PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKPPRnWKDSILTKNLILKILVSSII-I 786
Cdd:PRK10517 712 GNVfsVLVASAFL---PFlPMLPLHLLIQNLLYD--VSQvAIPFDNVDDEQIQKPQR-WNPADLGRFMVFFGPISSIFdI 785
                        810
                 ....*....|
gi 48762689  787 VCGTL--FVF 794
Cdd:PRK10517 786 LTFCLmwWVF 795
E1-E2_ATPase pfam00122
E1-E2 ATPase;
133-328 1.33e-49

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 173.14  E-value: 1.33e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaS 212
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSA-SVDESLLTGESLPVEK--------------K 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   213 RSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIL 292
Cdd:pfam00122  66 KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPL 145
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 48762689   293 EMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:pfam00122 146 RALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
29-97 2.68e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 77.24  E-value: 2.68e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48762689     29 LPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLM 97
Cdd:smart00831   7 LSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
54-896 0e+00

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 1586.27  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  54 RRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSK 133
Cdd:cd02085   1 RRKLHGPNEFKVEDEEPLWKKYLEQFKNPLILLLLGSAVVSVVMKQYDDAVSITVAILIVVTVAFVQEYRSEKSLEALNK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 134 LVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASR 213
Cdd:cd02085  81 LVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTTEVIPKASNGDLTTR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 214 SNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILE 293
Cdd:cd02085 161 SNIAFMGTLVRCGHGKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDKLGKQLSLYSFIIIGVIMLIGWLQGKNLLE 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 294 MFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglha 373
Cdd:cd02085 241 MFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVT------ 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 374 evtgvgynqfgevivdgdvvhgfynpavsriveaGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYP 453
Cdd:cd02085 315 ----------------------------------GCVCNNAVIRNNTLMGQPTEGALIALAMKMGLSDIRETYIRKQEIP 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 454 FSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQT-LTLTQQQRDVYQQEKARMGSAGLRVLALASGPE 532
Cdd:cd02085 361 FSSEQKWMAVKCIPKYNSDNEEIYFMKGALEQVLDYCTTYNSSDGSaLPLTQQQRSEINEEEKEMGSKGLRVLALASGPE 440
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 533 LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVP 612
Cdd:cd02085 441 LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSLQALSGEEVDQMSDSQLASVVR 520
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 613 KVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd02085 521 KVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEG 600
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILT 772
Cdd:cd02085 601 KGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILT 680
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 773 KNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSI 852
Cdd:cd02085 681 RSLILNVLLSAAIIVSGTLWVFWKEMSDDNVTPRDTTMTFTCFVFFDMFNALSCRSQTKSIFEIGFFSNRMFLYAVGGSL 760
                       810       820       830       840
                ....*....|....*....|....*....|....*....|....
gi 48762689 853 MGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02085 761 IGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
23-903 0e+00

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 1584.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    23 SKKASELPVSEVASILQADLQNGLN-KCEVSHRRAFHGWNEFDISEDEPLWKKYISQF-KNPLIMLLLASAVISVLMHQF 100
Cdd:TIGR01522   1 SKQYCELSVEETCSKLQTDLQNGLNsSQEASHRRAFHGWNEFDVEEDESLWKKFLSQFvKNPLILLLIASAVISVFMGNI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   101 DDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVD 180
Cdd:TIGR01522  81 DDAVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAVD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   181 LSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQK 260
Cdd:TIGR01522 161 LSIDESNLTGETTPVSKVTAPIPAATNGDLAERSNIAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTPLQK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   261 SMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:TIGR01522 241 SMDLLGKQLSLVSFGVIGVICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSVET 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   341 LGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNN- 419
Cdd:TIGR01522 321 LGSVNVICSDKTGTLTKNHMTVTKIWTSDGLHTMLNAVSLNQFGEVIVDGDVLHGFYTVAVSRILEAGNLCNNAKFRNEa 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   420 -TLMGKPTEGALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRtqQDRPEICFMKGAYEQVIKYCTTYQSK-G 497
Cdd:TIGR01522 401 dTLLGNPTDVALIELLMKFGLDDLRETYIRVAEVPFSSERKWMAVKCVHR--QDRSEMCFMKGAYEQVLKYCTYYQKKdG 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   498 QTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 577
Cdd:TIGR01522 479 KTLTLTQQQRDVIQEEAAEMASAGLRVIAFASGPEKGQLTFLGLVGINDPPRPGVKEAVTTLITGGVRIIMITGDSQETA 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   578 VAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 657
Cdd:TIGR01522 559 VSIARRLGMPSKTSQSVSGEKLDAMDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAMTGDGVNDAPALKLADI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   658 GVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWI 737
Cdd:TIGR01522 639 GVAMGQTGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVAALSLIALATLMGFPNPLNAMQILWI 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   738 NIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVF 817
Cdd:TIGR01522 719 NILMDGPPAQSLGVEPVDKDVMRKPPRPRNDKILTKDLIKKILVSAIIIVVGTLFVFVREMQDGVITARDTTMTFTCFVF 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   818 FDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKK 897
Cdd:TIGR01522 799 FDMFNALACRSQTKSVFEIGFFSNRMFNYAVGGSIIGQLLVIYFPPLQSVFQTEALSIKDLLFLLLITSSVCIVDEIRKK 878

                  ....*.
gi 48762689   898 VERSRE 903
Cdd:TIGR01522 879 VERSRE 884
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
22-904 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 1017.73  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  22 TSKKASELPVSEVASILQADlQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFD 101
Cdd:COG0474   4 ALKDWHALSAEEVLAELGTS-EEGLSSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISALLGDWV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 102 DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDL 181
Cdd:COG0474  83 DAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 182 SIDESSLTGETTPCSKVTAPQPAATNgdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKS 261
Cdd:COG0474 163 QVDESALTGESVPVEKSADPLPEDAP--LGDRGNMVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEEKTPLQKQ 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 262 MDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETL 341
Cdd:COG0474 241 LDRLGKLLAIIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETL 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 342 GCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAevtgvgynqfgevivdgdvVHGFYNPAVSRIVEAGCVCNDAVIRNNTL 421
Cdd:COG0474 321 GSVTVICTDKTGTLTQNKMTVERVYTGGGTYE-------------------VTGEFDPALEELLRAAALCSDAQLEEETG 381
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 422 MGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPeICFMKGAYEQVIKYCTTYQSKGQT 499
Cdd:COG0474 382 LGDPTEGALLVAAAKAGLDveELRKEYPRVDEIPFDSERKRMST--VHEDPDGKR-LLIVKGAPEVVLALCTRVLTGGGV 458
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 500 LTLTQQQRDVYQQEKARMGSAGLRVLALA-----SGPEL------GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKM 568
Cdd:COG0474 459 VPLTEEDRAEILEAVEELAAQGLRVLAVAykelpADPELdseddeSDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKM 538
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 569 ITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVND 648
Cdd:COG0474 539 ITGDHPATARAIARQLGLGDDGDRVLTGAELDAMSDEELAEAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVND 618
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 649 AVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNP 728
Cdd:COG0474 619 APALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLP 698
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 729 LNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDT 808
Cdd:COG0474 699 LTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALARGASLALAR 778
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 809 TMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSV 888
Cdd:COG0474 779 TMAFTTLVLSQLFNVFNCRSERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLY 858
                       890
                ....*....|....*.
gi 48762689 889 CIVAEIIKKVERSREK 904
Cdd:COG0474 859 LLLVELVKLLRRRFGR 874
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
45-896 0e+00

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 772.97  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd02080   1 GLTSEEAAERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHWVDAIVIFGVVLINAIIGYIQEGKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 125 EKSLEELSKLVPPECHCVREGKlEHTL-ARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQP 203
Cdd:cd02080  81 EKALAAIKNMLSPEATVLRDGK-KLTIdAEELVPGDIVLLEAGDKVPADLRLIEARNLQIDESALTGESVPVEKQEGPLE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 204 AATNgdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV 283
Cdd:cd02080 160 EDTP--LGDRKNMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLIVILVLAALTFVF 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 284 GWLLGK-DILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTV 362
Cdd:cd02080 238 GLLRGDySLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLTRNEMTV 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 363 THIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcVCNDAVIRNN----TLMGKPTEGALIALAMKMG 438
Cdd:cd02080 318 QAIVT------------------------------------------LCNDAQLHQEdghwKITGDPTEGALLVLAAKAG 355
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 439 LD--GLQQDYIRKAEYPFSSEQKWMAVkcvhRTQQDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLtqqQRDVYQQEKAR 516
Cdd:cd02080 356 LDpdRLASSYPRVDKIPFDSAYRYMAT----LHRDDGQRVIYVKGAPERLLDMCDQELLDGGVSPL---DRAYWEAEAED 428
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 517 MGSAGLRVLALASGPE------------LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRL 584
Cdd:cd02080 429 LAKQGLRVLAFAYREVdseveeidhadlEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQL 508
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 585 GLySKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQT 664
Cdd:cd02080 509 GL-GDGKKVLTGAELDALDDEELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGIK 587
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGP 744
Cdd:cd02080 588 GTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLGEGLVIIVAILFGVTLPLTPVQILWINMVTAIT 667
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 745 PAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNAL 824
Cdd:cd02080 668 LGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAFGLFLWALDRGYSLETARTMAVNTIVVAQIFYLF 747
                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48762689 825 SSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIK 896
Cdd:cd02080 748 NCRSLHRSILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFIVVELEK 819
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
45-764 0e+00

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 755.60  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSItVAILIVVTV-AFVQEYR 123
Cdd:cd02089   1 GLSEEEAERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVLGEYVDAIVI-IAIVILNAVlGFVQEYK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 124 SEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQP 203
Cdd:cd02089  80 AEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLRVEESSLTGESEPVEKDADTLL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 204 AATNGdLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV 283
Cdd:cd02089 160 EEDVP-LGDRKNMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETEEEKTPLQKRLDQLGKRLAIAALIICALVFAL 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 284 GWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVT 363
Cdd:cd02089 239 GLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLTQNKMTVE 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 364 HIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnntlMGKPTEGALIALAMKMGLD--G 441
Cdd:cd02089 319 KIYT------------------------------------------------------IGDPTETALIRAARKAGLDkeE 344
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 442 LQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRpeICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAG 521
Cdd:cd02089 345 LEKKYPRIAEIPFDSERKLMTT--VHKDAGKY--IVFTKGAPDVLLPRCTYIYINGQVRPLTEEDRAKILAVNEEFSEEA 420
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 522 LRVLALA----------SGPEL-GQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKT 590
Cdd:cd02089 421 LRVLAVAykpldedpteSSEDLeNDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILEDG 500
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 591 SQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 670
Cdd:cd02089 501 DKALTGEELDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGITGTDVAK 580
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLG 750
Cdd:cd02089 581 EAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALG 660
                       730
                ....*....|....
gi 48762689 751 VEPVDKDVIRKPPR 764
Cdd:cd02089 661 VEPAEPDIMDRKPR 674
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
29-870 0e+00

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 677.47  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  29 LPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSIT- 107
Cdd:cd02083   3 KTVEEVLAYFGVDPTRGLSDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFEEGEEGVt 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 108 ------VAILIVV---TVAFVQEYRSEKSLEELSKLVPPECHCVREGK-LEHTLARDLVPGDTVCLSVGDRVPADLRL-- 175
Cdd:cd02083  83 afvepfVILLILIanaVVGVWQERNAEKAIEALKEYEPEMAKVLRNGKgVQRIRARELVPGDIVEVAVGDKVPADIRIie 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 176 FEAVDLSIDESSLTGETTPCSKVTA--PQPAATNGDlasRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEA 253
Cdd:cd02083 163 IKSTTLRVDQSILTGESVSVIKHTDvvPDPRAVNQD---KKNMLFSGTNVAAGKARGVVVGTGLNTEIGKIRDEMAETEE 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 254 PKTPLQKSMDLLGKQLSFYSFGIIGIIMLV------------GWLLGKdiLEMFTISVSLAVAAIPEGLPIVVTVTLALG 321
Cdd:cd02083 240 EKTPLQQKLDEFGEQLSKVISVICVAVWAInighfndpahggSWIKGA--IYYFKIAVALAVAAIPEGLPAVITTCLALG 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 322 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHA-------EVTGVGYNQFGEVIVDGDVVH 394
Cdd:cd02083 318 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFILDKVEDdsslnefEVTGSTYAPEGEVFKNGKKVK 397
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 395 GFYNPAVSRIVEAGCVCNDAVIRNN------TLMGKPTEGALIALAMKMGLDG------------------LQQDYIRKA 450
Cdd:cd02083 398 AGQYDGLVELATICALCNDSSLDYNeskgvyEKVGEATETALTVLVEKMNVFNtdksglskreranacndvIEQLWKKEF 477
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 451 EYPFSSEQKWMAVKCVHRTQQDRPEIcFMKGAYEQVIKYCTTYQSKGQTLT-LTQQQRDVYQQEKARMGSAGLRVLALAS 529
Cdd:cd02083 478 TLEFSRDRKSMSVYCSPTKASGGNKL-FVKGAPEGVLERCTHVRVGGGKVVpLTAAIKILILKKVWGYGTDTLRCLALAT 556
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 530 GPELGQ------------------LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTS 591
Cdd:cd02083 557 KDTPPKpedmdledstkfykyetdLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDE 636
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 592 Q----SVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTD 667
Cdd:cd02083 637 DttgkSYTGREFDDLSPEEQREACRRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVNDAPALKKAEIGIAMG-SGTA 715
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 668 VCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQ 747
Cdd:cd02083 716 VAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPAT 795
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 748 SLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVF--------------WRELR-------------- 799
Cdd:cd02083 796 ALGFNPPDLDIMKKPPRKPDEPLISGWLFFRYLAIGTYVGLATVGAFawwfmyyeegpqvsFYQLThfmqcsswepnfeg 875
                       890       900       910       920       930       940       950
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48762689 800 ---DNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQT 870
Cdd:cd02083 876 vdcEIFEDPHPMTMALSVLVVIEMFNALNSLSENQSLLVMPPWSNPWLVGAIALSMALHFVILYVPPLATIFQI 949
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
76-900 0e+00

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 601.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    76 ISQFKNPLIMLLLASAVISVLMHQFDDAVSIT-------VAILIVV---TVAFVQEYRSEKSLEELSKLVPPECHCVREG 145
Cdd:TIGR01116   2 LEQFEDLLVRILLLAACVSFVLAWFEEGEETVtafvepfVILLILVanaIVGVWQERNAEKAIEALKEYESEHAKVLRDG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   146 KLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAaTNGDLASRSNIAFMGTLVRC 225
Cdd:TIGR01116  82 RWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTESVPD-ERAVNQDKKNMLFSGTLVVA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   226 GKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSfysfGIIGIIMLVGWLLG--------------KDI 291
Cdd:TIGR01116 161 GKARGVVVRTGMSTEIGKIRDEMRAAEQEDTPLQKKLDEFGELLS----KVIGLICILVWVINighfndpalgggwiQGA 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   292 LEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGL 371
Cdd:TIGR01116 237 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDPS 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   372 HAE-----VTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTL------MGKPTEGALIALAMKMGLD 440
Cdd:TIGR01116 317 SSSlnefcVTGTTYAPEGGVIKDDGPVAGGQDAGLEELATIAALCNDSSLDFNERkgvyekVGEATEAALKVLVEKMGLP 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   441 G------------------LQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDrpeiCFMKGAYEQVIKYCTTYQSK-GQTLT 501
Cdd:TIGR01116 397 AtkngvsskrrpalgcnsvWNDKFKKLATLEFSRDRKSMSVLCKPSTGNK----LFVKGAPEGVLERCTHILNGdGRAVP 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   502 LTQQQRDVYQQEKARMGSA-GLRVLALASGPELGQ------------------LTFLGLVGIIDPPRTGVKEAVTTLIAS 562
Cdd:TIGR01116 473 LTDKMKNTILSVIKEMGTTkALRCLALAFKDIPDPreedllsdpanfeaiesdLTFIGVVGMLDPPRPEVADAIEKCRTA 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   563 GVSIKMITGDSQETAVAIASRLGLYSK----TSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSV 638
Cdd:TIGR01116 553 GIRVIMITGDNKETAEAICRRIGIFSPdedvTFKSFTGREFDEMGPAKQRAACRSAVLFSRVEPSHKSELVELLQEQGEI 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   639 VAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLIS 718
Cdd:TIGR01116 633 VAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIF 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   719 LATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSI--IIVCGTLFVFWR 796
Cdd:TIGR01116 712 LTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITGWLFFRYLVVGVyvGLATVGGFVWWY 791
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   797 EL-------RDNVITPRD---------------TTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMG 854
Cdd:TIGR01116 792 LLthftgcdEDSFTTCPDfedpdcyvfegkqpaRTISLSVLVVIEMFNALNALSEDQSLLRMPPWVNKWLIGAICLSMAL 871
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|....*.
gi 48762689   855 QLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVER 900
Cdd:TIGR01116 872 HFLILYVPFLSRIFGVTPLSLTDWLMVLKLSLPVILVDEVLKFFSR 917
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
51-773 7.83e-162

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 491.72  E-value: 7.83e-162
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  51 VSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV---LMHQFDDA---------VSITVAILIVVTVAF 118
Cdd:cd02081   1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLglgFYTPFGEGegktgwiegVAILVAVILVVLVTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 119 VQEYRSEKSLEEL-SKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSK 197
Cdd:cd02081  81 GNDYQKEKQFRKLnSKKEDQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTGESDPIKK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 198 VTapqpaatngDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFG-- 275
Cdd:cd02081 161 TP---------DNQIPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEKTPLQEKLTKLAVQIGKVGLIva 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 276 -IIGIIMLVGWLL--------------GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:cd02081 232 aLTFIVLIIRFIIdgfvndgksfsaedLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACET 311
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 341 LGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnnt 420
Cdd:cd02081 312 MGNATAICSDKTGTLTQNRMTVVQGYI----------------------------------------------------- 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 421 lmGKPTEGALIALAMKMGLDglqQDYIRKAE-------YPFSSEQKWMAVkcVHRTQQDRPEIcFMKGAYEQVIKYCTTY 493
Cdd:cd02081 339 --GNKTECALLGFVLELGGD---YRYREKRPeekvlkvYPFNSARKRMST--VVRLKDGGYRL-YVKGASEIVLKKCSYI 410
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 494 QSK-GQTLTLTQQQRDVYQQEKARMGSAGLRVLALASG------------------PELGQLTFLGLVGIIDPPRTGVKE 554
Cdd:cd02081 411 LNSdGEVVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRdfspdeeptaerdwddeeDIESDLTFIGIVGIKDPLRPEVPE 490
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 555 AVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSV----------SGEEIDAMDVQQLSQIVPKVAVFYRASPRH 624
Cdd:cd02081 491 AVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLvlegkefrelIDEEVGEVCQEKFDKIWPKLRVLARSSPED 570
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 625 KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVR 704
Cdd:cd02081 571 KYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQ 650
                       730       740       750       760       770       780
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48762689 705 FQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTK 773
Cdd:cd02081 651 FQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISR 719
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
45-868 4.38e-161

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 496.21  E-value: 4.38e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd02086   1 GLTNDEAERRLKEYGENELEGDTGVSAWKILLRQVANAMTLVLIIAMALSFAVKDWIEGGVIAAVIALNVIVGFIQEYKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKvTAPQPA 204
Cdd:cd02086  81 EKTMDSLRNLSSPNAHVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGESLPVIK-DAELVF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 205 ATNGDL--ASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQ----AEEAPK----------------------- 255
Cdd:cd02086 160 GKEEDVsvGDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKALRgkggLISRDRvkswlygtlivtwdavgrflgtn 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 256 --TPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVK 333
Cdd:cd02086 240 vgTPLQRKLSKLAYLLFFIAVILAIIVFAVNKFDVDN--EVIIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVR 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 334 KLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvCND 413
Cdd:cd02086 318 KLDALEALGAVTDICSDKTGTLTQGKMVVRQVWIPAAL---------------------------------------CNI 358
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 414 AVIRNN------TLMGKPTEGALIALAMKMGL------DGLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPEICFMKG 481
Cdd:cd02086 359 ATVFKDeetdcwKAHGDPTEIALQVFATKFDMgknaltKGGSAQFQHVAEFPFDSTVKRMSV--VYYNNQAGDYYAYMKG 436
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 482 AYEQVIKYCTTYQSKGQTLTLTQQQRD--VYQQEKarMGSAGLRVLALAS--------------GPELGQ------LTFL 539
Cdd:cd02086 437 AVERVLECCSSMYGKDGIIPLDDEFRKtiIKNVES--LASQGLRVLAFASrsftkaqfnddqlkNITLSRadaesdLTFL 514
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 540 GLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGL-------YSKT---------SQ--SVSGEEIDA 601
Cdd:cd02086 515 GLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGIlppnsyhYSQEimdsmvmtaSQfdGLSDEEVDA 594
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 602 MDVQQLsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDD 681
Cdd:cd02086 595 LPVLPL--------VIARCSPQTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDN 666
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 682 FQTIMSAIEEGKGIYNNIKNFVRFQLSTSIA--ALTLISLA-----TLMNFpnPLNAMQILWINIIMDGPPAQSLGVEPV 754
Cdd:cd02086 667 FASIVNAIEEGRRMFDNIQKFVLHLLAENVAqvILLLIGLAfkdedGLSVF--PLSPVEILWINMVTSSFPAMGLGLEKA 744
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 755 DKDVIRKPPRNWKDSILTKNLILKILVSSII--IVCGTLFVF-----------------WRELRDNVITPRDTtmTFTCF 815
Cdd:cd02086 745 SPDVMQRPPHDLKVGIFTRELIIDTFVYGTFmgVLCLASFTLviygigngdlgsdcnesYNSSCEDVFRARAA--VFATL 822
                       890       900       910       920       930       940
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48762689 816 VFFDMFNALSSRSQTKSVFEIG-------------LCSNRMFCYAVLGSIMGQLLVIYFPPL-QKVF 868
Cdd:cd02086 823 TWCALILAWEVVDMRRSFFNMHpdtdspvksffktLWKNKFLFWSVVLGFVSVFPTLYIPVInDDVF 889
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
78-752 2.06e-142

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 438.39  E-value: 2.06e-142
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  78 QFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVRE--GKLEHTLARDL 155
Cdd:cd07539  35 QLELPPVALLGLAAGASASTGGGVDAVLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRApaGRTQTVPAESL 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 156 VPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAAtngDLASRSNIAFMGTLVRCGKAKGVVIGT 235
Cdd:cd07539 115 VPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDKQVAPTPGA---PLADRACMLYEGTTVVSGQGRAVVVAT 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 236 GENSEFGEVFKMMQAEEApKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVT 315
Cdd:cd07539 192 GPHTEAGRAQSLVAPVET-ATGVQAQLRELTSQLLPLSLGGGAAVTGLGLLRGAPLRQAVADGVSLAVAAVPEGLPLVAT 270
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 316 VTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhg 395
Cdd:cd07539 271 LAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRLRVVQVRP---------------------------- 322
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 396 fynpavsriveagcvcndavirnntlmgkPTegalialamkmgldglqqdyirkAEYPFSSEQKWMAVkcVHRTQQDRPE 475
Cdd:cd07539 323 -----------------------------PL-----------------------AELPFESSRGYAAA--IGRTGGGIPL 348
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 476 ICfMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALA-----SGPEL------GQLTFLGLVGI 544
Cdd:cd07539 349 LA-VKGAPEVVLPRCDRRMTGGQVVPLTEADRQAIEEVNELLAGQGLRVLAVAyrtldAGTTHaveavvDDLELLGLLGL 427
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 545 IDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLySKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRH 624
Cdd:cd07539 428 ADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL-PRDAEVVTGAELDALDEEALTGLVADIDVFARVSPEQ 506
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 625 KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVR 704
Cdd:cd07539 507 KLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVH 586
                       650       660       670       680
                ....*....|....*....|....*....|....*....|....*...
gi 48762689 705 FQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVE 752
Cdd:cd07539 587 VLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
31-872 3.68e-142

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 447.69  E-value: 3.68e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    31 VSEVASILQADLQNGL--NKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFD------- 101
Cdd:TIGR01517  45 AEGIATKLKTDLNEGVrlSSSTLERREKVYGKNELPEKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVpsvgedk 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   102 --------DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPP-ECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPAD 172
Cdd:TIGR01517 125 adtetgwiEGVAILVSVILVVLVTAVNDYKKELQFRQLNREKSAqKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPAD 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   173 LRLFEAVDLSIDESSLTGETTPcSKVTAPQPaatngdlasrsNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEE 252
Cdd:TIGR01517 205 GVFISGLSLEIDESSITGESDP-IKKGPVQD-----------PFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   253 APKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLL------------------GKDILEMFTISVSLAVAAIPEGLPIVV 314
Cdd:TIGR01517 273 EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRyvfriirgdgrfedteedAQTFLDHFIIAVTIVVVAVPEGLPLAV 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   315 TVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSdGLHAEVTGVGYNQFGEVIVDGDVVH 394
Cdd:TIGR01517 353 TIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIG-EQRFNVRDEIVLRNLPAAVRNILVE 431
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   395 GFY-NPAVSRIVEAGcvcndaviRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKAE-----YPFSSEQKWMAVKCVHR 468
Cdd:TIGR01517 432 GISlNSSSEEVVDRG--------GKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEkvvkiYPFNSERKFMSVVVKHS 503
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   469 TQQDRpeiCFMKGAYEQVIKYCTTYQSKGQTLT-LTQQQRDVYQQEKARMGSAGLRVLALA-----------SGPELGQL 536
Cdd:TIGR01517 504 GGKYR---EFRKGASEIVLKPCRKRLDSNGEATpISEDDKDRCADVIEPLASDALRTICLAyrdfapeefprKDYPNKGL 580
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   537 TFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAV 616
Cdd:TIGR01517 581 TLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGGLAMEGKEFRSLVYEEMDPILPKLRV 660
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   617 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIY 696
Cdd:TIGR01517 661 LARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVY 740
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   697 NNIKNFVRFQLSTSIAALTLISLATLM--NFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKN 774
Cdd:TIGR01517 741 DNIRKFLQFQLTVNVVAVILTFVGSCIssSHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRS 820
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   775 LILKILVSSI--IIVCGTLFVFWRELRD----NVITPRDT----TMTFTCFVFFDMFNALSSRS--QTKSVFEiGLCSNR 842
Cdd:TIGR01517 821 MWKNILGQAGyqLVVTFILLFAGGSIFDvsgpDEITSHQQgelnTIVFNTFVLLQLFNEINARKlyEGMNVFE-GLFKNR 899
                         890       900       910
                  ....*....|....*....|....*....|
gi 48762689   843 MFCYAVLGSIMGQLLVIYFppLQKVFQTES 872
Cdd:TIGR01517 900 IFVTIMGFTFGFQVIIVEF--GGSFFSTVS 927
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
45-778 1.69e-138

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 428.78  E-value: 1.69e-138
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd07538   1 GLTEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQEWRT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPA 204
Cdd:cd07538  81 ERALEALKNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDESTLTGESVPVWKRIDGKAM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 205 ATNGdlASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVG 284
Cdd:cd07538 161 SAPG--GWDKNFCYAGTLVVRGRGVAKVEATGSRTELGKIGKSLAEMDDEPTPLQKQTGRLVKLCALAALVFCALIVAVY 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 285 WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTH 364
Cdd:cd07538 239 GVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLTKNQMEVVE 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 365 IFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndaVIRnntlmgkptegalialamkmgldglqq 444
Cdd:cd07538 319 LTS-----------------------------------------------LVR--------------------------- 324
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 445 dyirkaEYPFSSEQKWMAvkcvHRTQQDRPEICFMKGAYEQVIKYCTtyqskgqtltLTQQQRDVYQQEKARMGSAGLRV 524
Cdd:cd07538 325 ------EYPLRPELRMMG----QVWKRPEGAFAAAKGSPEAIIRLCR----------LNPDEKAAIEDAVSEMAGEGLRV 384
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 525 LALASG--------PELGQLTF--LGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLySKTSQSV 594
Cdd:cd07538 385 LAVAACridesflpDDLEDAVFifVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGL-DNTDNVI 463
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 595 SGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAAD 674
Cdd:cd07538 464 TGQELDAMSDEELAEKVRDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASD 543
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 675 MILVDDDFQTIMSAIEEGKGIYNNIKN---FVrFQLSTSIAALTLisLATLMNFPNPLNAMQILWINIIMDGPPAQSLGV 751
Cdd:cd07538 544 IVLLDDNFSSIVSTIRLGRRIYDNLKKaitYV-FAIHVPIAGLAL--LPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEA 620
                       730       740
                ....*....|....*....|....*..
gi 48762689 752 EPVDKDVIRKPPRNWKDSILTKNLILK 778
Cdd:cd07538 621 EPAERDIMRRPPRPPDEPLFGPRLVIK 647
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
33-794 4.03e-130

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 418.65  E-value: 4.03e-130
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689     33 EVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILI 112
Cdd:TIGR01523   14 EAAEFIGTSIPEGLTHDEAQHRLKEVGENRLEADSGIDAKAMLLHQVCNAMCMVLIIAAAISFAMHDWIEGGVISAIIAL 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    113 VVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGET 192
Cdd:TIGR01523   94 NILIGFIQEYKAEKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFDTDEALLTGES 173
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    193 TPCSK----VTAPQPAATNGDlasRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAE---------EAPK---- 255
Cdd:TIGR01523  174 LPVIKdahaTFGKEEDTPIGD---RINLAFSSSAVTKGRAKGICIATALNSEIGAIAAGLQGDgglfqrpekDDPNkrrk 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    256 ----------------------TPLQKSMDLLGKQLsFYSFGIIGIIMLVGWLLGKDiLEMFTISVSLAVAAIPEGLPIV 313
Cdd:TIGR01523  251 lnkwilkvtkkvtgaflglnvgTPLHRKLSKLAVIL-FCIAIIFAIIVMAAHKFDVD-KEVAIYAICLAISIIPESLIAV 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    314 VTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIF----------TSD-------------- 369
Cdd:TIGR01523  329 LSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWiprfgtisidNSDdafnpnegnvsgip 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    370 ------GLHAEVTGVGYNQ-FGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNT------LMGKPTEGALIALAMK 436
Cdd:TIGR01523  409 rfspyeYSHNEAADQDILKeFKDELKEIDLPEDIDMDLFIKLLETAALANIATVFKDDatdcwkAHGDPTEIAIHVFAKK 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    437 MGL-----------------------------DGLQQDYIRkaEYPFSSEQKWMAVkcVHRTQQDRPEICFMKGAYEQVI 487
Cdd:TIGR01523  489 FDLphnaltgeedllksnendqsslsqhnekpGSAQFEFIA--EFPFDSEIKRMAS--IYEDNHGETYNIYAKGAFERII 564
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    488 KYCTTYQSKG--QTLTLTQQQRDVYQQEKARMGSAGLRVLALAS---------GPELGQLT-----------FLGLVGII 545
Cdd:TIGR01523  565 ECCSSSNGKDgvKISPLEDCDRELIIANMESLAAEGLRVLAFASksfdkadnnDDQLKNETlnrataesdleFLGLIGIY 644
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    546 DPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLG-----LYSKTSQSVS-----GEEIDAMDVQQLSQIVPKVA 615
Cdd:TIGR01523  645 DPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGiippnFIHDRDEIMDsmvmtGSQFDALSDEEVDDLKALCL 724
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    616 VFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGI 695
Cdd:TIGR01523  725 VIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRM 804
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    696 YNNIKNFVRFQLSTSIAALTLISLATLMNFPN-----PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSI 770
Cdd:TIGR01523  805 FDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGI 884
                          890       900
                   ....*....|....*....|....
gi 48762689    771 LTKNLILKILVSSIIIVCGTLFVF 794
Cdd:TIGR01523  885 FQKELIIDMFAYGFFLGGSCLASF 908
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
45-794 8.75e-130

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 409.72  E-value: 8.75e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVIS----VLMHQ----FDDAVSITVAILIVVTV 116
Cdd:cd02077   1 GLTNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSfftdVLLAPgefdLVGALIILLMVLISGLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 117 AFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARD-LVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPC 195
Cdd:cd02077  81 DFIQEIRSLKAAEKLKKMVKNTATVIRDGSKYMEIPIDeLVPGDIVYLSAGDMIPADVRIIQSKDLFVSQSSLTGESEPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 196 SKVTAPQpAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQaEEAPKTPLQKSMDLLGKQLSFYSFG 275
Cdd:cd02077 161 EKHATAK-KTKDESILELENICFMGTNVVSGSALAVVIATGNDTYFGSIAKSIT-EKRPETSFDKGINKVSKLLIRFMLV 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 276 IIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTL 355
Cdd:cd02077 239 MVPVVFLINGLTKGDWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILCTDKTGTL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 356 TKNEMTVTHIFTSDGlhaevtgvgynQFGEVIVDgdvvHGFYNPavsrIVEAGcvcndavIRNntLMGKptegALIALAM 435
Cdd:cd02077 319 TQDKIVLERHLDVNG-----------KESERVLR----LAYLNS----YFQTG-------LKN--LLDK----AIIDHAE 366
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 436 KMGLDGLQQDYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKA 515
Cdd:cd02077 367 EANANGLIQDYTKIDEIPFDFERRRMSV-VVKDNDGKHLLIT--KGAVEEILNVCTHVEVNGEVVPLTDTLREKILAQVE 443
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 516 RMGSAGLRVLALA----SGPELG-------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRL 584
Cdd:cd02077 444 ELNREGLRVLAIAykklPAPEGEysvkdekELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQV 523
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 585 GLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQT 664
Cdd:cd02077 524 GL--DINRVLTGSEIEALSDEELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISV-DS 600
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLAT-LMNFpNPLNAMQILWINIIMDg 743
Cdd:cd02077 601 AVDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNFGNVFSVLVASaFLPF-LPMLPIQLLLQNLLYD- 678
                       730       740       750       760       770
                ....*....|....*....|....*....|....*....|....*....|....*
gi 48762689 744 pPAQ-SLGVEPVDKDVIRKpPRNWKDSILTKNLILKILVSSI---IIVCGTLFVF 794
Cdd:cd02077 679 -FSQlAIPFDNVDEEFLKK-PQKWDIKNIGRFMIWIGPISSIfdiLTFLVMWFVF 731
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
45-776 1.44e-127

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 407.89  E-value: 1.44e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  45 GLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMH----QFDDAVS-------ITVAILIV 113
Cdd:cd02608   1 GLTSARAAEILARDGPNALTPPPTTPEWVKFCKQLFGGFSMLLWIGAILCFLAYgiqaATEEEPSndnlylgIVLAAVVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 114 VT--VAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGE 191
Cdd:cd02608  81 VTgcFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 192 TTPCSKvtapQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD-------- 263
Cdd:cd02608 161 SEPQTR----SPEFTHENPLETKNIAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEVGKTPIAREIEhfihiitg 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 264 ---LLGkqlsfYSFGIIGIIMLVGWLlgkdilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVET 340
Cdd:cd02608 237 vavFLG-----VSFFILSLILGYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVET 305
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 341 LGCCNVICSDKTGTLTKNEMTVTHIFtsdglhaevtgvgynqFGEVIVDGDVVHGFYN----------PAVSRIVeagCV 410
Cdd:cd02608 306 LGSTSTICSDKTGTLTQNRMTVAHMW----------------FDNQIHEADTTEDQSGasfdkssatwLALSRIA---GL 366
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 411 CNDAVIRNN---------TLMGKPTEGALIALA-MKMG-LDGLQQDYIRKAEYPFSSEQKWMAvkCVHRTQQDRPE--IC 477
Cdd:cd02608 367 CNRAEFKAGqenvpilkrDVNGDASESALLKCIeLSCGsVMEMRERNPKVAEIPFNSTNKYQL--SIHENEDPGDPryLL 444
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 478 FMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALA-------SGPE------------LGQLTF 538
Cdd:cd02608 445 VMKGAPERILDRCSTILINGKEQPLDEEMKEAFQNAYLELGGLGERVLGFChlylpddKFPEgfkfdtdevnfpTENLCF 524
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 539 LGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeidamdvqqlsqivpkVAVFY 618
Cdd:cd02608 525 VGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVG----------------------------IIVFA 576
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 619 RASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNN 698
Cdd:cd02608 577 RTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDN 656
                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48762689 699 IKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRN-WKDSILTKNLI 776
Cdd:cd02608 657 LKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNpKTDKLVNERLI 735
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
28-776 4.30e-127

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 409.18  E-value: 4.30e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    28 ELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQF------- 100
Cdd:TIGR01106  19 KLSLDELERKYGTDLSKGLSAARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIqasteee 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   101 --DDAVSITVAILIVVTV----AFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLR 174
Cdd:TIGR01106  99 pqNDNLYLGVVLSAVVIItgcfSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLR 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   175 LFEAVDLSIDESSLTGETTPCSKvtapQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAP 254
Cdd:TIGR01106 179 IISAQGCKVDNSSLTGESEPQTR----SPEFTHENPLETRNIAFFSTNCVEGTARGIVVNTGDRTVMGRIASLASGLENG 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   255 KTPLQKSMD-----LLGKQLSF-YSFGIIGIIMLVGWLlgkdilEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:TIGR01106 255 KTPIAIEIEhfihiITGVAVFLgVSFFILSLILGYTWL------EAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARK 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   329 RAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLH-AEVT----GVGYNQFGEVIVdgdvvhgfynpAVSR 403
Cdd:TIGR01106 329 NCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHeADTTedqsGVSFDKSSATWL-----------ALSR 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   404 IVEagcVCNDAVIRNN---------TLMGKPTEGALIA-LAMKMG-LDGLQQDYIRKAEYPFSSEQKWMAvkCVHRTQ-- 470
Cdd:TIGR01106 398 IAG---LCNRAVFKAGqenvpilkrAVAGDASESALLKcIELCLGsVMEMRERNPKVVEIPFNSTNKYQL--SIHENEdp 472
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   471 QDRPEICFMKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVL-----ALASG--PE----------- 532
Cdd:TIGR01106 473 RDPRHLLVMKGAPERILERCSSILIHGKEQPLDEELKEAFQNAYLELGGLGERVLgfchlYLPDEqfPEgfqfdtddvnf 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   533 -LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVS---------------- 595
Cdd:TIGR01106 553 pTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEdiaarlnipvsqvnpr 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   596 --------GEEIDAMDVQQLSQIV---PKVaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQT 664
Cdd:TIGR01106 633 dakacvvhGSDLKDMTSEQLDEILkyhTEI-VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA 711
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGP 744
Cdd:TIGR01106 712 GSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTITILCIDLGTDMV 791
                         810       820       830
                  ....*....|....*....|....*....|...
gi 48762689   745 PAQSLGVEPVDKDVIRKPPRN-WKDSILTKNLI 776
Cdd:TIGR01106 792 PAISLAYEKAESDIMKRQPRNpKTDKLVNERLI 824
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
105-735 3.06e-120

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 377.43  E-value: 3.06e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   105 SITVAILIVVTVAFVQEYRSEKSLEELSKLV--PPECHCVREGKLEHTlARDLVPGDTVCLSVGDRVPADLRLFEAvDLS 182
Cdd:TIGR01494   1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLvnTATVLVLRNGWKEIS-SKDLVPGDVVLVKSGDTVPADGVLLSG-SAF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   183 IDESSLTGETTPCSKVTAPQPAATNGdlasrsniafmGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSM 262
Cdd:TIGR01494  79 VDESSLTGESLPVLKTALPDGDAVFA-----------GTINFGGTLIVKVTATGILTTVGKIAVVVYTGFSTKTPLQSKA 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   263 DLLGKQLSFYSFGIIGIIMLVGWLL----GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIV 338
Cdd:TIGR01494 148 DKFENFIFILFLLLLALAVFLLLPIggwdGNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNAL 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   339 ETLGCCNVICSDKTGTLTKNEMTVTHIFTsDGLHAEVTGVGYNQFGEvivdgdvvhgfynpavsriveagcvcndavirN 418
Cdd:TIGR01494 228 EELGKVDVICFDKTGTLTTNKMTLQKVII-IGGVEEASLALALLAAS--------------------------------L 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   419 NTLMGKPTEGALIALAMKMG-LDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPeicFMKGAYEQVIKYCTtyqskg 497
Cdd:TIGR01494 275 EYLSGHPLERAIVKSAEGVIkSDEINVEYKILDVFPFSSVLKRMGVIVEGANGSDLL---FVKGAPEFVLERCN------ 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   498 qtltltqqQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETA 577
Cdd:TIGR01494 346 --------NENDYDEKVDEYARQGLRVLAFASKKLPDDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTA 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   578 VAIASRLGLysktsqsvsgeeidamdvqqlsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADI 657
Cdd:TIGR01494 418 KAIAKELGI----------------------------DVFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADV 469
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48762689   658 GVAMGQtgTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:TIGR01494 470 GIAMGS--GDVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVIILLPPLLAALAL 545
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
45-860 7.79e-120

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 383.89  E-value: 7.79e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  45 GLNKCEVSHRRAFHGWNEFDiSEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:cd02076   1 GLTSEEAAKRLKEYGPNELP-EKKENPILKFLSFFWGPIPWMLEAAAILAAALGDWVDFAIILLLLLINAGIGFIEERQA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKvtapqpa 204
Cdd:cd02076  80 GNAVAALKKSLAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALTGESLPVTK------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 205 aTNGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEaPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVG 284
Cdd:cd02076 153 -HPGD------EAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAE-EQGHLQKVLNKIGNFLILLALILVLIIVIVA 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 285 WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTH 364
Cdd:cd02076 225 LYRHDPFLEILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKLSLDE 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 365 IFTSDGLHAEvtgvgynqfgEVIVdgdvvhgfynpavsriveAGCVCNDAviRNNTLMGKPTEGALIALamKMGLDGLQQ 444
Cdd:cd02076 305 PYSLEGDGKD----------ELLL------------------LAALASDT--ENPDAIDTAILNALDDY--KPDLAGYKQ 352
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 445 -DYirkaeYPFSSEqkwmaVKCVHRTQQDRPEICF--MKGAYEQVIKYCttyqskgqtlTLTQQQRDVYQQEKARMGSAG 521
Cdd:cd02076 353 lKF-----TPFDPV-----DKRTEATVEDPDGERFkvTKGAPQVILELV----------GNDEAIRQAVEEKIDELASRG 412
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 522 LRVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK---TSQSVSGEE 598
Cdd:cd02076 413 YRSLGVARKEDGGRWELLGLLPLFDPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMGTNilsAERLKLGGG 492
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 599 IDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILV 678
Cdd:cd02076 493 GGGMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAV-SGATDAARAAADIVLT 571
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 679 DDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGpPAQSLGvepVDKDV 758
Cdd:cd02076 572 APGLSVIIDAIKTSRQIFQRMKSYVIYRIAETLRILVFFTLGILILNFYPLPLIMIVLIAILNDG-ATLTIA---YDNVP 647
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 759 IRKPPRNWKdsiLTKNLILKIL------VSSIIIVC---GTLFVFWRELRDNVItprdTTMTFTCFVFFDMFNALSSRsq 829
Cdd:cd02076 648 PSPRPVRWN---MPELLGIATVlgvvltISSFLLLWlldDQGWFEDIVLSAGEL----QTILYLQLSISGHLTIFVTR-- 718
                       810       820       830
                ....*....|....*....|....*....|.
gi 48762689 830 TKSVFEIGLCSNRMFCYAVLGSIMGQLLVIY 860
Cdd:cd02076 719 TRGPFWRPRPSPLLFIAVVLTQILATLLAVY 749
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
45-744 1.62e-112

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 363.57  E-value: 1.62e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    45 GLNKCEVSHRRAFHGWNEFdISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRS 124
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNEL-PEKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALENWVDFVIILGLLLLNATIGFIEENKA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   125 EKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTapqpa 204
Cdd:TIGR01647  80 GNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGESLPVTKKT----- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   205 atnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVG 284
Cdd:TIGR01647 155 ---GD------IAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTETGSGHLQKILSKIGLFLIVLIGVLVLIELVVL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   285 WLL-GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVT 363
Cdd:TIGR01647 226 FFGrGESFREGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKTGTLTLNKLSID 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   364 HIFTsdglhaevtgvgynQFGEVIVDGDVVHGFYnpaVSRivEAGcvcNDAVirNNTLMGKptegaLIALAMKMgldglq 443
Cdd:TIGR01647 306 EILP--------------FFNGFDKDDVLLYAAL---ASR--EED---QDAI--DTAVLGS-----AKDLKEAR------ 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   444 qDYIRKAEY-PFSSEQKwmAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYqskgqtltltQQQRDVYQQEKARMGSAGL 522
Cdd:TIGR01647 351 -DGYKVLEFvPFDPVDK--RTEATVEDPETGKRFKVTKGAPQVILDLCDNK----------KEIEEKVEEKVDELASRGY 417
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   523 RVLALASGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK--TSQSVSGEEID 600
Cdd:TIGR01647 418 RALGVARTDEEGRWHFLGLLPLFDPPRHDTKETIERARHLGVEVKMVTGDHLAIAKETARRLGLGTNiyTADVLLKGDNR 497
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   601 AMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDD 680
Cdd:TIGR01647 498 DDLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDGVNDAPALKKADVGIAV-AGATDAARSAADIVLTEP 576
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48762689   681 DFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATL-MNFpnPLNAMQILWINIIMDGP 744
Cdd:TIGR01647 577 GLSVIVDAILESRKIFQRMKSYVIYRIAETIRIVFFFGLLILiLNF--YFPPIMVVIIAILNDGT 639
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
346-749 1.13e-107

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 335.96  E-value: 1.13e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 346 VICSDKTGTLTKNEMTVTHIFTsdglhaevtgvgynqfgevivdgdvvhgfynpavsriveagcvcndavirnntlmgkp 425
Cdd:cd01431   1 VICSDKTGTLTKNGMTVTKLFI---------------------------------------------------------- 22
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 426 tegalialamkmgldglqqdyirkAEYPFSSEQKWMAVKCVHrtqqDRPEICFMKGAYEQVIKYCTTyqskgqtlTLTQQ 505
Cdd:cd01431  23 ------------------------EEIPFNSTRKRMSVVVRL----PGRYRAIVKGAPETILSRCSH--------ALTEE 66
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 506 QRDVYQQEKARMGSAGLRVLALASGP---------ELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQET 576
Cdd:cd01431  67 DRNKIEKAQEESAREGLRVLALAYREfdpetskeaVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLT 146
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 577 AVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAAD 656
Cdd:cd01431 147 AIAIAREIGIDTKASGVILGEEADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQAD 226
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 657 IGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILW 736
Cdd:cd01431 227 VGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIALALFLGGPLPLLAFQILW 306
                       410
                ....*....|...
gi 48762689 737 INIIMDGPPAQSL 749
Cdd:cd01431 307 INLVTDLIPALAL 319
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
18-794 3.93e-104

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 345.13  E-value: 3.93e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   18 IPVLTSKKASELPVSEVASILQA--DLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISV 95
Cdd:PRK10517  38 VPPSLSARCLKAAVMPEEELWKTfdTHPEGLNEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNPFNILLTILGAISY 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   96 LMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR--EGKLEHTLA----RDLVPGDTVCLSVGDRV 169
Cdd:PRK10517 118 ATEDLFAAGVIALMVAISTLLNFIQEARSTKAADALKAMVSNTATVLRviNDKGENGWLeipiDQLVPGDIIKLAAGDMI 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  170 PADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQ 249
Cdd:PRK10517 198 PADLRILQARDLFVAQASLTGESLPVEKFATTRQPEHSNPL-ECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLAGRVS 276
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  250 AEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLV-GWLLGkDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:PRK10517 277 EQDSEPNAFQQGISRVSWLLIRFMLVMAPVVLLInGYTKG-DWWEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQ 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  329 RAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthIFTSDglHAEVtgvgynqFGEviVDGDVVH-----GFYNPAVSR 403
Cdd:PRK10517 356 KVIVKRLDAIQNFGAMDILCTDKTGTLTQDK-----IVLEN--HTDI-------SGK--TSERVLHsawlnSHYQTGLKN 419
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  404 IVEAgcvcndAVIrnntlmgkptEGALIALAMKMGldglqQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPE-ICfmKGA 482
Cdd:PRK10517 420 LLDT------AVL----------EGVDEESARSLA-----SRWQKIDEIPFDFERRRMSV--VVAENTEHHQlIC--KGA 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  483 YEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGP-----------ELGQLTFLGLVGIIDPPRTG 551
Cdd:PRK10517 475 LEEILNVCSQVRHNGEIVPLDDIMLRRIKRVTDTLNRQGLRVVAVATKYlparegdyqraDESDLILEGYIAFLDPPKET 554
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  552 VKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKS 631
Cdd:PRK10517 555 TAPALKALKASGVTVKILTGDSELVAAKVCHEVGL--DAGEVLIGSDIETLSDDELANLAERTTLFARLTPMHKERIVTL 632
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  632 LQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSI 711
Cdd:PRK10517 633 LKREGHVVGFMGDGINDAPALRAADIGISV-DGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYIKMTASSNF 711
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  712 AAL--TLISLATLmnfPN-PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKPPRnWKDSILTKNLILKILVSSII-I 786
Cdd:PRK10517 712 GNVfsVLVASAFL---PFlPMLPLHLLIQNLLYD--VSQvAIPFDNVDDEQIQKPQR-WNPADLGRFMVFFGPISSIFdI 785
                        810
                 ....*....|
gi 48762689  787 VCGTL--FVF 794
Cdd:PRK10517 786 LTFCLmwWVF 795
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
25-795 5.57e-103

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 341.08  E-value: 5.57e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    25 KASELPVSEVASILQAdLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMHQFDDAV 104
Cdd:TIGR01524  14 KESQMGKETLLRKLGV-HETGLTNVEVTERLAEFGPNQTVEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYLTDDLEATV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   105 SITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR------EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEA 178
Cdd:TIGR01524  93 IIALMVLASGLLGFIQESRAERAAYALKNMVKNTATVLRvinengNGSMDEVPIDALVPGDLIELAAGDIIPADARVISA 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   179 VDLSIDESSLTGETTPCSKVTAPQPAATNgDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMqAEEAPKTPL 258
Cdd:TIGR01524 173 RDLFINQSALTGESLPVEKFVEDKRARDP-EILERENLCFMGTNVLSGHAQAVVLATGSSTWFGSLAIAA-TERRGQTAF 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   259 QKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIV 338
Cdd:TIGR01524 251 DKGVKSVSKLLIRFMLVMVPVVLMINGLMKGDWLEAFLFALAVAVGLTPEMLPMIVSSNLAKGAINMSKKKVIVKELSAI 330
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   339 ETLGCCNVICSDKTGTLTKNEMTVTHiftsdglHAEVTGVGYNQfgevivdgdVVHGFYNPAVSRiVEAGCVCNDAVIRn 418
Cdd:TIGR01524 331 QNFGAMDILCTDKTGTLTQDKIELEK-------HIDSSGETSER---------VLKMAWLNSYFQ-TGWKNVLDHAVLA- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   419 ntlmgKPTEGALIALAMKmgldglqqdYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYCTTYQSKGQ 498
Cdd:TIGR01524 393 -----KLDESAARQTASR---------WKKVDEIPFDFDRRRLSV-VVENRAEVTRLIC--KGAVEEMLTVCTHKRFGGA 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   499 TLTLTQQQRDVYQQEKARMGSAGLRVLALAS--GPELG---------QLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIK 567
Cdd:TIGR01524 456 VVTLSESEKSELQDMTAEMNRQGIRVIAVATktLKVGEadftktdeeQLIIEGFLGFLDPPKESTKEAIAALFKNGINVK 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   568 MITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVN 647
Cdd:TIGR01524 536 VLTGDNEIVTARICQEVGI--DANDFLLGADIEELSDEELARELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGIN 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   648 DAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPN 727
Cdd:TIGR01524 614 DAPALRKADVGISV-DTAADIAKEASDIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVASAFIPFL 692
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48762689   728 PLNAMQILWINIIMDGPPAqSLGVEPVDKDVIRKpPRNWKDSILTKNLILKILVSSIIIVCGTLFVFW 795
Cdd:TIGR01524 693 PMLSLHLLIQNLLYDFSQL-TLPWDKMDREFLKK-PHQWEQKGMGRFMLCIGPVSSIFDIATFLLMWF 758
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
43-766 1.07e-90

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 308.49  E-value: 1.07e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   43 QNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLM------HQFDDAVSITVAILIV-VT 115
Cdd:PRK15122  43 RQGLTEEDAAERLQRYGPNEVAHEKPPHALVQLLQAFNNPFIYVLMVLAAISFFTdywlplRRGEETDLTGVIIILTmVL 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  116 VA----FVQEYRSEKSLEELSKLVPPECHCVR------EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDE 185
Cdd:PRK15122 123 LSgllrFWQEFRSNKAAEALKAMVRTTATVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQ 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  186 SSLTGETTPCSKV---------TAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEaPKT 256
Cdd:PRK15122 203 AVLTGEALPVEKYdtlgavagkSADALADDEGSLLDLPNICFMGTNVVSGTATAVVVATGSRTYFGSLAKSIVGTR-AQT 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  257 PLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLP 336
Cdd:PRK15122 282 AFDRGVNSVSWLLIRFMLVMVPVVLLINGFTKGDWLEALLFALAVAVGLTPEMLPMIVSSNLAKGAIAMARRKVVVKRLN 361
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  337 IVETLGCCNVICSDKTGTLTKNEMTVTHiftsdglHaevtgvgynqfgeviVDgdvVHGFYNPAVSRIV------EAGcv 410
Cdd:PRK15122 362 AIQNFGAMDVLCTDKTGTLTQDRIILEH-------H---------------LD---VSGRKDERVLQLAwlnsfhQSG-- 414
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  411 cndavIRNntLMGKptegALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVkCVHRTQQDRPEICfmKGAYEQVIKYC 490
Cdd:PRK15122 415 -----MKN--LMDQ----AVVAFAEGNPEIVKPAGYRKVDELPFDFVRRRLSV-VVEDAQGQHLLIC--KGAVEEMLAVA 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  491 TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASgPELGQ--------------LTFLGLVGIIDPPRTGVKEAV 556
Cdd:PRK15122 481 THVRDGDTVRPLDEARRERLLALAEAYNADGFRVLLVAT-REIPGgesraqystaderdLVIRGFLTFLDPPKESAAPAI 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  557 TTLIASGVSIKMITGDSQETAVAIASRLGLysKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNG 636
Cdd:PRK15122 560 AALRENGVAVKVLTGDNPIVTAKICREVGL--EPGEPLLGTEIEAMDDAALAREVEERTVFAKLTPLQKSRVLKALQANG 637
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  637 SVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTsiaaltl 716
Cdd:PRK15122 638 HTVGFLGDGINDAPALRDADVGISV-DSGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYLNMTASS------- 709
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48762689  717 islatlmNFPN--------------PLNAMQILWINIIMDgpPAQ-SLGVEPVDKDVIRKpPRNW 766
Cdd:PRK15122 710 -------NFGNvfsvlvasafipflPMLAIHLLLQNLMYD--ISQlSLPWDKMDKEFLRK-PRKW 764
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
86-766 1.62e-82

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 280.32  E-value: 1.62e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  86 LLLASAVISVLMHQFDDAVSITVAILIVVtVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSV 165
Cdd:cd02609  42 INFVIAVLLILVGSYSNLAFLGVIIVNTV-IGIVQEIRAKRQLDKLSILNAPKVTVIRDGQEVKIPPEELVLDDILILKP 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 166 GDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTapqpaatnGDLAsrsniaFMGTLVRCGKAKGVVIGTGENSefgevF 245
Cdd:cd02609 121 GEQIPADGEVVEGGGLEVDESLLTGESDLIPKKA--------GDKL------LSGSFVVSGAAYARVTAVGAES-----Y 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 246 KMMQAEEAPK-----TPLQKSMDLLGKqlsFYSFGII--GIIMLVG--WLLGKDILEMFTISVSLAVAAIPEGLPIVVTV 316
Cdd:cd02609 182 AAKLTLEAKKhklinSELLNSINKILK---FTSFIIIplGLLLFVEalFRRGGGWRQAVVSTVAALLGMIPEGLVLLTSV 258
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 317 TLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLhaevtgvgynqfgevivdgdvvhgf 396
Cdd:cd02609 259 ALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEA------------------------- 313
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 397 YNPAVSRIVEAGCvcnDAVIRNNtlmgkPTEGALialamkmgLDGLQQD--YIRKAEYPFSSEQKWMAVkcvhrTQQDR- 473
Cdd:cd02609 314 NEAEAAAALAAFV---AASEDNN-----ATMQAI--------RAAFFGNnrFEVTSIIPFSSARKWSAV-----EFRDGg 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 474 ------PEIcFMKGAYEQVikycttyqskgqtltltQQQRDVYQQEkarmgsaGLRVLALASGPE-------LGQLTFLG 540
Cdd:cd02609 373 twvlgaPEV-LLGDLPSEV-----------------LSRVNELAAQ-------GYRVLLLARSAGaltheqlPVGLEPLA 427
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 541 LVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLysktsqsvSGEEIDA-----MDVQQLSQIVPKVA 615
Cdd:cd02609 428 LILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGL--------EGAESYIdastlTTDEELAEAVENYT 499
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 616 VFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGI 695
Cdd:cd02609 500 VFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRV 578
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 696 YNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRK----------PPRN 765
Cdd:cd02609 579 VNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRRIEGGflrrvltkalPPLN 658

                .
gi 48762689 766 W 766
Cdd:cd02609 659 R 659
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
84-731 3.53e-58

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 209.79  E-value: 3.53e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    84 IMLLLASAVI-SVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR-EGKLEHTLARDLVPGDTV 161
Cdd:TIGR01525   1 MDTLMALAAIaAYAMGLVLEGALLLFLFLLGETLEERAKSRASDALSALLALAPSTARVLQgDGSEEEVPVEELQVGDIV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   162 CLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEF 241
Cdd:TIGR01525  81 IVRPGERIPVDGVVISGES-EVDESALTGESMPVEK--------------KEGDEVFAGTINGDGSLTIRVTKLGEDSTL 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   242 GEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALG 321
Cdd:TIGR01525 146 AQIVELVEEAQSSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYRALTVLVVACPCALGLATPVAILVA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   322 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHI-FTSDGLHAEVTGVgynqfgevivdgdvvhgfynpa 400
Cdd:TIGR01525 226 IGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIePLDDASEEELLAL---------------------- 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   401 vsriveAGCvcndavirnntlMGKPTEGAlIALAMkmgldglqQDYIRKAEYPFSSEQkwmavkcvhrtQQDRPEiCFMK 480
Cdd:TIGR01525 284 ------AAA------------LEQSSSHP-LARAI--------VRYAKERGLELPPED-----------VEEVPG-KGVE 324
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   481 GAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELgqltfLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:TIGR01525 325 ATVDGGREVRIGNPRFLGNRELAIEPISASPDLLNEGESQGKTVVFVAVDGEL-----LGVIALRDQLRPEAKEAIAALK 399
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   561 ASGV-SIKMITGDSQETAVAIASRLGLYSKtsqsvsgeeidamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVV 639
Cdd:TIGR01525 400 RAGGiKLVMLTGDNRSAAEAVAAELGIDDE--------------------------VHAELLPEDKLAIVKKLQEEGGPV 453
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   640 AMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NFVrfqlstsiAALTLIS 718
Cdd:TIGR01525 454 AMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKqNLA--------WALGYNL 524
                         650
                  ....*....|....*.
gi 48762689   719 LA---TLMNFPNPLNA 731
Cdd:TIGR01525 525 VAiplAAGGLLPLWLA 540
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
83-703 4.68e-57

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 210.00  E-value: 4.68e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  83 LIML-LLASAVISVL------MHQFDDAVsitVAILIVVTVA-FVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTL 151
Cdd:COG2217 151 LVALgTLAAFLYSLYatlfgaGHVYFEAA---AMIIFLLLLGrYLEARakgRARAAIRALLSLQPKTARVLRDGEEVEVP 227
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 152 ARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTLVRCGKAKGV 231
Cdd:COG2217 228 VEELRVGDRVLVRPGERIPVDGVVLEG-ESSVDESMLTGESLPVEKTP--------GD------EVFAGTINLDGSLRVR 292
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 232 VIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGL- 310
Cdd:COG2217 293 VTKVGSDTTLARIIRLVEEAQSSKAPIQRLADRIARYFVPAVLAIAALTFLVWLLFGGDFSTALYRAVAVLVIACPCALg 372
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 311 ---PIVVTVtlALGvmRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVI 387
Cdd:COG2217 373 latPTAIMV--GTG--RAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDVVPLDGLDED----------ELL 438
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 388 vdgdvvhgfynpAVSRIVEAGcvcndavirnntlmgkpTE----GALIALAMKMGLDGLQQDYIR-------KAEYpfsS 456
Cdd:COG2217 439 ------------ALAAALEQG-----------------SEhplaRAIVAAAKERGLELPEVEDFEaipgkgvEATV---D 486
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 457 EQKWMAVkcvhrtqqdRPEicFMKgayeqvikycttyqSKGQTLTltqqqrDVYQQEKARMGSAGLRVLALASGpelGQL 536
Cdd:COG2217 487 GKRVLVG---------SPR--LLE--------------EEGIDLP------EALEERAEELEAEGKTVVYVAVD---GRL 532
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 537 tfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvaV 616
Cdd:COG2217 533 --LGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELG-------------IDE--------------V 583
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 617 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIY 696
Cdd:COG2217 584 RAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATM 662

                ....*...
gi 48762689 697 NNIK-NFV 703
Cdd:COG2217 663 RIIRqNLF 670
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
82-732 8.87e-54

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 198.21  E-value: 8.87e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  82 PLIMLLLASAVI-----SVLMHQ------FDDAVSITVAILIVvtvAFVQEY---RSEKSLEELSKLVPPECHCVREGKL 147
Cdd:cd02079  59 LNMDVLVSLAAIgafvaSLLTPLlggigyFEEAAMLLFLFLLG---RYLEERarsRARSALKALLSLAPETATVLEDGST 135
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 148 EHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTLVRCGK 227
Cdd:cd02079 136 EEVPVDDLKVGDVVLVKPGERIPVDGVVVSGES-SVDESSLTGESLPVEKGA--------GD------TVFAGTINLNGP 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 228 AKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIP 307
Cdd:cd02079 201 LTIEVTKTGEDTTLAKIIRLVEEAQSSKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLALYRALAVLVVACP 280
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 308 EGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVI 387
Cdd:cd02079 281 CALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEIEPLEGFSED----------ELL 350
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 388 vdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPtegalIALAMkmgldglqQDYIRKAEypfsseqkwmAVKCVH 467
Cdd:cd02079 351 ------------ALAAALEQHS-------------EHP-----LARAI--------VEAAEEKG----------LPPLEV 382
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 468 RTQQDRPEicfmKGAYEQVIkycttyqskGQTLTLTQQ---QRDVYQQEKARMGSAG-LRVLALASGPELgqltfLGLVG 543
Cdd:cd02079 383 EDVEEIPG----KGISGEVD---------GREVLIGSLsfaEEEGLVEAADALSDAGkTSAVYVGRDGKL-----VGLFA 444
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 544 IIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSktsqsvsgeeidamdvqqlsqivpkvaVFYRASPR 623
Cdd:cd02079 445 LEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGIDE---------------------------VHAGLLPE 497
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 624 HKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NF 702
Cdd:cd02079 498 DKLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGS-GTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKqNL 576
                       650       660       670
                ....*....|....*....|....*....|
gi 48762689 703 VrFQLSTSIAALTLislaTLMNFPNPLNAM 732
Cdd:cd02079 577 A-WALGYNAIALPL----AALGLLTPWIAA 601
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
86-731 1.60e-50

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 187.53  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    86 LLLASAVISVLMHQFDDAVSItvaILIVVTVAFVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVC 162
Cdd:TIGR01512   4 LMALAALGAVAIGEYLEGALL---LLLFSIGETLEEYasgRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGDVVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   163 LSVGDRVPADLRLfEAVDLSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFG 242
Cdd:TIGR01512  81 VKPGERVPVDGEV-LSGTSSVDESALTGESVPVEK--------------APGDEVFAGAINLDGVLTIEVTKLPADSTIA 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   243 EVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKD-ILEMFTISVSLAVAAIPEGLPIVVTVTLALG 321
Cdd:TIGR01512 146 KIVNLVEEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVPPLLGAGpFLEWIYRALVLLVVASPCALVISAPAAYLSA 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   322 VMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgevivdgdvvhGFYNPAV 401
Cdd:TIGR01512 226 ISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTDVHPADGHSES--------------------EVLRLAA 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   402 SriVEAGCVcndavirnntlmgKPtegalIALAMkmgldglqQDYIRKAEYPFSSEQkwmavkcvhrtQQDRPEicfmKG 481
Cdd:TIGR01512 286 A--AEQGST-------------HP-----LARAI--------VDYARARELAPPVED-----------VEEVPG----EG 322
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   482 AYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQekarmgSAGLRVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIA 561
Cdd:TIGR01512 323 VRAVVDGGEVRIGNPRSLSEAVGASIAVPES------AGKTIVLVARDG------TLLGYIALSDELRPDAAEAIAELKA 390
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   562 SGVS-IKMITGDSQETAVAIASRLGlysktsqsvsgeeIDamdvqqlsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVA 640
Cdd:TIGR01512 391 LGIKrLVMLTGDRRAVAEAVARELG-------------ID--------------EVHAELLPEDKLEIVKELREKAGPVA 443
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   641 MTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFqlstSIAALTLISLA 720
Cdd:TIGR01512 444 MVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVI----ALGIILVLILL 519
                         650
                  ....*....|.
gi 48762689   721 TLMNFPNPLNA 731
Cdd:TIGR01512 520 ALFGVLPLWLA 530
E1-E2_ATPase pfam00122
E1-E2 ATPase;
133-328 1.33e-49

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 173.14  E-value: 1.33e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaatngdlaS 212
Cdd:pfam00122   1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSA-SVDESLLTGESLPVEK--------------K 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   213 RSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIL 292
Cdd:pfam00122  66 KGDMVYSGTVVVSGSAKAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPL 145
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 48762689   293 EMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK 328
Cdd:pfam00122 146 RALLRALAVLVAACPCALPLATPLALAVGARRLAKK 181
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
128-733 5.95e-49

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 184.43  E-value: 5.95e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 128 LEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQ--PAA 205
Cdd:cd07552 122 LKKLAELLPKTAHLVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEG-ESSVNESMVTGESKPVEKKPGDEviGGS 200
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 206 TNGDlasrsniafmGTL-VRcgkakgvVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLsFYSFGIIGIIMLVG 284
Cdd:cd07552 201 VNGN----------GTLeVK-------VTKTGEDSYLSQVMELVAQAQASKSRAENLADKVAGWL-FYIALGVGIIAFII 262
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 285 WLLGKDILEMFTISVSLAVAAIPEGL----PIVVTVTLALGVMR--MVKKRaivKKLPIVETLgccNVICSDKTGTLTKN 358
Cdd:cd07552 263 WLILGDLAFALERAVTVLVIACPHALglaiPLVVARSTSIAAKNglLIRNR---EALERARDI---DVVLFDKTGTLTEG 336
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 359 EMTVTHIFTSDGLHAEvtgvgynqfgEVI-----VDGDVVHgfynPAVSRIVEAgcvcndavirnntlmgkptegalial 433
Cdd:cd07552 337 KFGVTDVITFDEYDED----------EILslaaaLEAGSEH----PLAQAIVSA-------------------------- 376
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 434 amkmgldgLQQdyiRKAEYPFSSEQKWMAVKCVHRTQQDRpeicfmkgayeqvikyctTYQSKGQTLtLTQQQRDVYQQE 513
Cdd:cd07552 377 --------AKE---KGIRPVEVENFENIPGVGVEGTVNGK------------------RYQVVSPKY-LKELGLKYDEEL 426
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 514 KARMGSAGLRVLALASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSktsqs 593
Cdd:cd07552 427 VKRLAQQGNTVSFLIQDGEV-----IGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGIDE----- 496
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 594 vsgeeidamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAA 673
Cdd:cd07552 497 ----------------------YFAEVLPEDKAKKVKELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESA 553
                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48762689 674 DMILVDDDFQTIMSAIEEGKGIYNNIK---------NFVRFQLSTSIAALTLISL-----ATLMNFPN---PLNAMQ 733
Cdd:cd07552 554 DVVLVKSDPRDIVDFLELAKATYRKMKqnlwwgagyNVIAIPLAAGVLAPIGIILspavgAVLMSLSTvivAINAMT 630
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
43-869 4.14e-48

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 186.03  E-value: 4.14e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689     43 QNGLNKCEVSHRRAFHGWNEFDI---SEDEPLWKkyisQFKNPLIMLLLASaVISVLMHQFDDAVSITVAILIVVTVAFV 119
Cdd:TIGR01657  137 SNGLTTGDIAQRKAKYGKNEIEIpvpSFLELLKE----EVLHPFYVFQVFS-VILWLLDEYYYYSLCIVFMSSTSISLSV 211
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    120 QEYRseKSLEELSKLV-PPECHCV-REGKLEHTLARDLVPGDtvCLSVGDR----VPADLRLFEAvDLSIDESSLTGETT 193
Cdd:TIGR01657  212 YQIR--KQMQRLRDMVhKPQSVIViRNGKWVTIASDELVPGD--IVSIPRPeektMPCDSVLLSG-SCIVNESMLTGESV 286
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    194 PCSKVTAPQPAATNGDLA----SRSNIAFMGTLV-------RCGKAKGVVIGTGENSEFGE-VFKMMQAEEAPKTPLQKS 261
Cdd:TIGR01657  287 PVLKFPIPDNGDDDEDLFlyetSKKHVLFGGTKIlqirpypGDTGCLAIVVRTGFSTSKGQlVRSILYPKPRVFKFYKDS 366
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    262 MDLLGKQLSFYSFGIIGIImLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMvKKRAIVKKLPI-VET 340
Cdd:TIGR01657  367 FKFILFLAVLALIGFIYTI-IELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARL-KKKGIFCTSPFrINF 444
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    341 LGCCNVICSDKTGTLTknemtvthiftSDGLHAE-VTGVGYNQFGEVIVDGDVvhgfyNPAVSRIVEAGCVCNDAVIRNN 419
Cdd:TIGR01657  445 AGKIDVCCFDKTGTLT-----------EDGLDLRgVQGLSGNQEFLKIVTEDS-----SLKPSITHKALATCHSLTKLEG 508
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    420 TLMGKPTEGAL-------------------IALAMKMGLDGLQQDYIRKaeYPFSSEQKWMAVKCvhRTQQDRPEICFMK 480
Cdd:TIGR01657  509 KLVGDPLDKKMfeatgwtleeddesaeptsILAVVRTDDPPQELSIIRR--FQFSSALQRMSVIV--STNDERSPDAFVK 584
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    481 GAYEQVIKYCttyqsKGQTLtltqqQRDvYQQEKARMGSAGLRVLALASGPeLGQ-----------------LTFLGLVG 543
Cdd:TIGR01657  585 GAPETIQSLC-----SPETV-----PSD-YQEVLKSYTREGYRVLALAYKE-LPKltlqkaqdlsrdavesnLTFLGFIV 652
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    544 IIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSK---------------------------TSQSVSG 596
Cdd:TIGR01657  653 FENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPsntlilaeaeppesgkpnqikfevidsIPFASTQ 732
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    597 EEID-----------------------------AMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVN 647
Cdd:TIGR01657  733 VEIPyplgqdsvedllasryhlamsgkafavlqAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGAN 812
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    648 DAVALKAADIGVAMGQTGTDVckeAADMILVDDDFQTIMSAIEEGKGiyNNIKNFVRFQLSTSIAALTLISLATLMNFPN 727
Cdd:TIGR01657  813 DCGALKQADVGISLSEAEASV---AAPFTSKLASISCVPNVIREGRC--ALVTSFQMFKYMALYSLIQFYSVSILYLIGS 887
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    728 PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPrnwKDSILTKNLILKILvSSIIIVCGTLFVFWREL-------RD 800
Cdd:TIGR01657  888 NLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERP---PSNLFSVYILTSVL-IQFVLHILSQVYLVFELhaqpwykPE 963
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    801 NVITPRDT---TMTFTCFVFFDMFNALSsrsqTKSVFEIG------LCSNRMFCYAVLGSIMG-QLLVIYFPPLQ-KVFQ 869
Cdd:TIGR01657  964 NPVDLEKEnfpNLLNTVLFFVSSFQYLI----TAIVNSKGppfrepIYKNKPFVYLLITGLGLlLVLLLDPHPLLgKILQ 1039
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
100-703 8.40e-48

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 179.78  E-value: 8.40e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLA-RDLVPGDTVCLSVGDRVPADLRLFEA 178
Cdd:TIGR01511  54 FDASAMLITFILLGRWLEMLAKGRASDALSKLAKLQPSTATLLTKDGSIEEVPvALLQPGDIVKVLPGEKIPVDGTVIEG 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   179 vDLSIDESSLTGETTPCSKVTapqpaatnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPL 258
Cdd:TIGR01511 134 -ESEVDESLVTGESLPVPKKV--------GD------PVIAGTVNGTGSLVVRATATGEDTTLAQIVRLVRQAQQSKAPI 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   259 QKSMDLLGKQLsFYSFGIIGIIMLVGWLLGkdilemFTISVSLAVAAIPEGL----PIVVTVTLALGVMRMVkkraIVKK 334
Cdd:TIGR01511 199 QRLADKVAGYF-VPVVIAIALITFVIWLFA------LEFAVTVLIIACPCALglatPTVIAVATGLAAKNGV----LIKD 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   335 LPIVETLGCCNVICSDKTGTLTKNEMTVTHI-FTSDGLHAEVTgvgynqfgevivdgdvvhgfynpavsriveagcvcnd 413
Cdd:TIGR01511 268 GDALERAANIDTVVFDKTGTLTQGKPTVTDVhVFGDRDRTELL------------------------------------- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   414 avirnnTLMGKPTEGALIALAMKMgldglqQDYIRKAEYPFSSEQKWMAVK-CVHRTQQDRPEICFMKGAYEQVIKYCTT 492
Cdd:TIGR01511 311 ------ALAAALEAGSEHPLAKAI------VSYAKEKGITLVTVSDFKAIPgIGVEGTVEGTKIQLGNEKLLGENAIKID 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   493 YQSKGQTltltqqqrdvyqqekarmgsagLRVLALASGpELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGD 572
Cdd:TIGR01511 379 GKAGQGS----------------------TVVLVAVNG-EL-----AGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGD 430
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   573 SQETAVAIASRLGlysktsqsvsgeeIDamdvqqlsqivpkvaVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVAL 652
Cdd:TIGR01511 431 NRKTAKAVAKELG-------------ID---------------VRAEVLPDDKAALIKKLQEKGPVVAMVGDGINDAPAL 482
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 48762689   653 KAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK-NFV 703
Cdd:TIGR01511 483 AQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKqNLL 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
83-703 2.25e-46

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 176.90  E-value: 2.25e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  83 LIMLLLASAVISVLMHQFDDAVsitvailiVVTVAFVQ-----EYRS-EKSLEELSKLV---PPECHCVREGKLEHTLAR 153
Cdd:cd02094  84 LVALLFPALFPGGAPHVYFEAA--------AVIITFILlgkylEARAkGKTSEAIKKLLglqPKTARVIRDGKEVEVPIE 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 154 DLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSK-----VTApqpAATNGDlasrsniafmGTLVrcGKA 228
Cdd:cd02094 156 EVQVGDIVRVRPGEKIPVDGVVVEG-ESSVDESMLTGESLPVEKkpgdkVIG---GTINGN----------GSLL--VRA 219
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 229 KGVvigtGENSEFGEVFKMMQAEEAPKTPLQKSMDllgkQLSFYsF--GIIGI--IMLVGWLL---GKDILEMFTISVSL 301
Cdd:cd02094 220 TRV----GADTTLAQIIRLVEEAQGSKAPIQRLAD----RVSGV-FvpVVIAIaiLTFLVWLLlgpEPALTFALVAAVAV 290
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 302 AVAAIPEGL----PIVVTVtlalGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtg 377
Cdd:cd02094 291 LVIACPCALglatPTAIMV----GTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVTDVVPLPGDDED--- 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 378 vgynqfgEVIvdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPTEGALIALAMKMGLDGLQQDYIR-------KA 450
Cdd:cd02094 364 -------ELL------------RLAASLEQGS-------------EHPLAKAIVAAAKEKGLELPEVEDFEaipgkgvRG 411
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 451 EYP----FSSEQKWMAVKCVHRTQQDrpeicfmkgayeqvikycttyqskgqtltltqqqrdvyqQEKARMGSAGLRVLA 526
Cdd:cd02094 412 TVDgrrvLVGNRRLMEENGIDLSALE---------------------------------------AEALALEEEGKTVVL 452
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 527 LASGPELgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDamdvqq 606
Cdd:cd02094 453 VAVDGEL-----AGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELG-------------ID------ 508
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 607 lsqivpkvAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIM 686
Cdd:cd02094 509 --------EVIAEVLPEDKAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVV 579
                       650
                ....*....|....*...
gi 48762689 687 SAIEEGKGIYNNIK-NFV 703
Cdd:cd02094 580 TAIDLSRATMRNIKqNLF 597
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
726-898 1.07e-45

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 162.02  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   726 PNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWRELRDNVITP 805
Cdd:pfam00689   1 PLPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   806 RDT--TMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLG 883
Cdd:pfam00689  81 SQNaqTMAFNTLVLSQLFNALNARSLRRSLFKIGLFSNKLLLLAILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLL 160
                         170
                  ....*....|....*
gi 48762689   884 LTSSVCIVAEIIKKV 898
Cdd:pfam00689 161 LALVVLLVVELRKLL 175
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
50-793 4.88e-45

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 174.74  E-value: 4.88e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  50 EVSHRRAFHGWNEFDISEDePLWKKYISQFKNPLIMLllasAVISVLMHQFDDAVSITVAILIV----VTVAFVQEYRSE 125
Cdd:cd07542   2 EQSDRRLIYGPNEIDVPLK-SILKLLFKEVLNPFYVF----QLFSVILWSSDDYYYYAACIVIIsvisIFLSLYETRKQS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 126 KSLEELSKLVPPECHCvREGKLEHTLARDLVPGDTVCLSV-GDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQPA 204
Cdd:cd07542  77 KRLREMVHFTCPVRVI-RDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSG-SCIVNESMLTGESVPVTKTPLPDES 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 205 ATNGDLAS-----RSNIAFMGTLV------RCGKAKGVVIGTGENSEFGE-VFKMMQAEEAPKTPLQKSMDLLGKQ--LS 270
Cdd:cd07542 155 NDSLWSIYsiedhSKHTLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQlVRSILYPKPVDFKFYRDSMKFILFLaiIA 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 271 FYSFGIIGIIMLvgwLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMvKKRAIVKKLPI-VETLGCCNVICS 349
Cdd:cd07542 235 LIGFIYTLIILI---LNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRL-KKKGIFCISPQrINICGKINLVCF 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 350 DKTGTLTKNEMTVTHIFTSDGlhaevtgvgyNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPtega 429
Cdd:cd07542 311 DKTGTLTEDGLDLWGVRPVSG----------NNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSLTLIDGELVGDP---- 376
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 430 liaLAMKM------GLDGLQQdyirkaeYPFSSEQKWMAVKCVHrTQQDRPEIcFMKGAYEQVIKYC------TTYQSKG 497
Cdd:cd07542 377 ---LDLKMfeftgwSLEILRQ-------FPFSSALQRMSVIVKT-PGDDSMMA-FTKGAPEMIASLCkpetvpSNFQEVL 444
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 498 QTLTltqqqrdvyqqekarmgSAGLRVLALAS-----GPELGQ----------LTFLGLVGIIDPPRTGVKEAVTTLIAS 562
Cdd:cd07542 445 NEYT-----------------KQGFRVIALAYkalesKTWLLQklsreevesdLEFLGLIVMENRLKPETAPVINELNRA 507
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 563 GVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGE--EIDAMDVQQLS-QIVPKVAVFYRASPRHKMKIIKSLQKNGSVV 639
Cdd:cd07542 508 NIRTVMVTGDNLLTAISVARECGMISPSKKVILIEavKPEDDDSASLTwTLLLKGTVFARMSPDQKSELVEELQKLDYTV 587
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 640 AMTGDGVNDAVALKAADIGVAMGQTGTDVckeAADMILVDDDFQTIMSAIEEGkgiynniknfvRFQLSTSIAALTLISL 719
Cdd:cd07542 588 GMCGDGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDISCVPTVIKEG-----------RAALVTSFSCFKYMAL 653
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 720 ATLMNF---------PNPLNAMQILWINIIMDGPPAQSLG-VEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCG 789
Cdd:cd07542 654 YSLIQFisvlilysiNSNLGDFQFLFIDLVIITPIAVFMSrTGAYPKLSSKRPPASLVSPPVLVSLLGQIVLILLFQVIG 733

                ....
gi 48762689 790 TLFV 793
Cdd:cd07542 734 FLIV 737
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
85-726 1.01e-44

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 171.66  E-value: 1.01e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  85 MLLLASAVISVLMHQFDDAvsitvAILIVV--TVAFVQEY---RSEKSLEELSKLVPPECHCV-REGKLEHTLARDLVPG 158
Cdd:cd07551  60 LLMILAAIGAAAIGYWAEG-----ALLIFIfsLSHALEDYamgRSKRAITALMQLAPETARRIqRDGEIEEVPVEELQIG 134
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 159 DTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTLVRCGKAKGVVIGTGEN 238
Cdd:cd07551 135 DRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEK--------TPGDEV------FAGTINGSGALTVRVTKLSSD 199
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 239 SEFGEVFKMMQAEEAPKTPLQKSMDllgKQLSFYSFGIIGII---MLVG-WLLGKDILEMFTISVSLAVAAIPEGLPIVV 314
Cdd:cd07551 200 TVFAKIVQLVEEAQSEKSPTQSFIE---RFERIYVKGVLLAVlllLLLPpFLLGWTWADSFYRAMVFLVVASPCALVAST 276
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 315 TVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVIvdgdvvh 394
Cdd:cd07551 277 PPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVIPAEGVDEE----------ELL------- 339
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 395 gfynpavsRIVEAgcvcndavirnntlMGKPTEGALiALAMkmgldglqqdyIRKAEypfsseqkwmavkcvHRTQQDRP 474
Cdd:cd07551 340 --------QVAAA--------------AESQSEHPL-AQAI-----------VRYAE---------------ERGIPRLP 370
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 475 EICFmkgayEQVIKYCTTYQSKGQTLTLTQQQRdvYQQEKARMGSAGLRVLALASGPEL-----GQlTFLGLVGIIDPPR 549
Cdd:cd07551 371 AIEV-----EAVTGKGVTATVDGQTYRIGKPGF--FGEVGIPSEAAALAAELESEGKTVvyvarDD-QVVGLIALMDTPR 442
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 550 TGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvavfYRAS--PRHKMK 627
Cdd:cd07551 443 PEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELG-------------IDE----------------VVANllPEDKVA 493
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 628 IIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQL 707
Cdd:cd07551 494 IIRELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRRIIKQNLIFAL 572
                       650
                ....*....|....*....
gi 48762689 708 sTSIAALTLISLATLMNFP 726
Cdd:cd07551 573 -AVIALLIVANLFGLLNLP 590
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
70-703 1.37e-43

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 167.84  E-value: 1.37e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  70 PLWKKYISQFKN--PLIMLLLASAVI-SVLMHQFDDAVSIT----VAILIVVTVAfvqeYRSEKSLEELSKLVPPECHCV 142
Cdd:cd07550  30 PVLRRALESLKErrLNVDVLDSLAVLlSLLTGDYLAANTIAflleLGELLEDYTA----RKSEKALLDLLSPQERTVWVE 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 143 REGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLsIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTL 222
Cdd:cd07550 106 RDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK--------REGDLV------FASTV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 223 VRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIImlvgWLLGKDI---LEMFTISV 299
Cdd:cd07550 171 VEEGQLVIRAERVGRETRAARIAELIEQSPSLKARIQNYAERLADRLVPPTLGLAGLV----YALTGDIsraAAVLLVDF 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 300 SLAVaaipeGLPIVVTVtlaLGVMRMVKKRAI-VKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGV 378
Cdd:cd07550 247 SCGI-----RLSTPVAV---LSALNHAARHGIlVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAIITFDGRLSEEDLL 318
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 379 GYNqfgevivdGDVVHGFYNPAVSRIVEAgcvcndAVIRNNTLMGKPTEGALIALAMKMGLDGLQqdyIRKAEYPFsseq 458
Cdd:cd07550 319 YLA--------ASAEEHFPHPVARAIVRE------AEERGIEHPEHEEVEYIVGHGIASTVDGKR---IRVGSRHF---- 377
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 459 kwMAvkcvhrtQQDRPEICFMKGAYEqvikyctTYQSKGQTLtltqqqrdvyqqekarmgsaglrvLALASGPELgqltf 538
Cdd:cd07550 378 --ME-------EEEIILIPEVDELIE-------DLHAEGKSL------------------------LYVAIDGRL----- 412
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 539 LGLVGIIDPPRTGVKEAVTTLIASGV-SIKMITGDSQETAVAIASRLGlysktsqsvsgeeIDAmdvqqlsqivpkvaVF 617
Cdd:cd07550 413 IGVIGLSDPLRPEAAEVIARLRALGGkRIIMLTGDHEQRARALAEQLG-------------IDR--------------YH 465
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 618 YRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYN 697
Cdd:cd07550 466 AEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISMRG-GTDIARETADVVLLEDDLRGLAEAIELARETMA 544

                ....*..
gi 48762689 698 NIK-NFV 703
Cdd:cd07550 545 LIKrNIA 551
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
123-722 1.10e-42

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 165.27  E-value: 1.10e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 123 RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKVT-AP 201
Cdd:cd07546  85 RARSGVKALMALVPETALREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAgDK 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 202 QPA-ATNGDLASRsniafmgtlVRCGKAKgvvigtGENSeFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSFGIIGII 280
Cdd:cd07546 164 VFAgSINVDGVLR---------IRVTSAP------GDNA-IDRILHLIEEAEERRAPIERFIDRFSR---WYTPAIMAVA 224
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 281 MLVG----WLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356
Cdd:cd07546 225 LLVIvvppLLFGADWQTWIYRGLALLLIGCPCALVISTPAAITSGLAAAARRGALIKGGAALEQLGRVTTVAFDKTGTLT 304
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 357 KNEMTVTHIFTSDGLHAevtgvgynqfGEVIvdgdvvhgfynpAVSRIVEAGCvcndavirnntlmGKPTEGALIALAMK 436
Cdd:cd07546 305 RGKPVVTDVVPLTGISE----------AELL------------ALAAAVEMGS-------------SHPLAQAIVARAQA 349
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 437 MGLdglqqdyirkaEYPFSSEQKWMAVKCVHRTQQDRP-EICFMKGAYEQVikyctTYQSKGQTLTLTQQQRDVyqqeka 515
Cdd:cd07546 350 AGL-----------TIPPAEEARALVGRGIEGQVDGERvLIGAPKFAADRG-----TLEVQGRIAALEQAGKTV------ 407
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 516 rmgsaglrVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYsktsqsvs 595
Cdd:cd07546 408 --------VVVLANG------RVLGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGLD-------- 465
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 596 geeidamdvqqlsqivpkvavfYRAS--PRHKMKIIKSLQKNGSvVAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAA 673
Cdd:cd07546 466 ----------------------FRAGllPEDKVKAVRELAQHGP-VAMVGDGINDAPAMKAASIGIAMG-SGTDVALETA 521
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 48762689 674 DMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLS-------TSIAALTLISLATL 722
Cdd:cd07546 522 DAALTHNRLGGVAAMIELSRATLANIRQNITIALGlkavflvTTLLGITGLWLAVL 577
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
50-661 8.64e-37

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 149.28  E-value: 8.64e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  50 EVSHRRAFHGWNEFDI---SEDEPLWKkyisQFKNPLIMLLLASAVISVLMHQFDDAVSItVAILIVVTVAFVQEYRSEK 126
Cdd:cd02082   1 RVDQLLAYYGKNEIEInvpSFLTLMWR----EFKKPFNFFQYFGVILWGIDEYVYYAITV-VFMTTINSLSCIYIRGVMQ 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 127 SLEELSKLVPPECHCVREGKLEHTLARD-LVPGDTVCLSV-GDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQPA 204
Cdd:cd02082  76 KELKDACLNNTSVIVQRHGYQEITIASNmIVPGDIVLIKRrEVTLPCDCVLLEG-SCIVTEAMLTGESVPIGKCQIPTDS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 205 ATNG---DLASRSNIAFMGTLVRCGKA------KGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLgkQLSFYSFG 275
Cdd:cd02082 155 HDDVlfkYESSKSHTLFQGTQVMQIIPpeddilKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKF--TLLLATLA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 276 IIGIIMLvgWLLGKDI----LEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDK 351
Cdd:cd02082 233 LIGFLYT--LIRLLDIelppLFIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDK 310
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 352 TGTLTKNEMTVTHIftsdglhaevTGVGYNQFGevivdgDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALI 431
Cdd:cd02082 311 TGTLTEDKLDLIGY----------QLKGQNQTF------DPIQCQDPNNISIEHKLFAICHSLTKINGKLLGDPLDVKMA 374
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 432 -ALAMKMGLDGLQQDYIRKA---------EYPFSSEQKWMAVKC--VHRTQQDRPEICFMKGAYEQVIKYCTTYQS--KG 497
Cdd:cd02082 375 eASTWDLDYDHEAKQHYSKSgtkrfyiiqVFQFHSALQRMSVVAkeVDMITKDFKHYAFIKGAPEKIQSLFSHVPSdeKA 454
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 498 QTLTLTQQqrdvyqqekarmgsaGLRVLALASgPELGQLT-----------------FLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:cd02082 455 QLSTLINE---------------GYRVLALGY-KELPQSEidafldlsreaqeanvqFLGFIIYKNNLKPDTQAVIKEFK 518
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 561 ASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEI---DAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGS 637
Cdd:cd02082 519 EACYRIVMITGDNPLTALKVAQELEIINRKNPTIIIHLLipeIQKDNSTQWILIIHTNVFARTAPEQKQTIIRLLKESDY 598
                       650       660
                ....*....|....*....|....
gi 48762689 638 VVAMTGDGVNDAVALKAADIGVAM 661
Cdd:cd02082 599 IVCMCGDGANDCGALKEADVGISL 622
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
143-661 1.08e-36

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 149.07  E-value: 1.08e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 143 REGKLEHTLARDLVPGDTVCLSVGDR---VPADLRLFEAVDLsIDESSLTGETTPCSK---VTAPQPAATNGDLASRSNI 216
Cdd:cd07543  92 RDGKWVPISSDELLPGDLVSIGRSAEdnlVPCDLLLLRGSCI-VNEAMLTGESVPLMKepiEDRDPEDVLDDDGDDKLHV 170
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 217 AFMGTLV-------RCG-KAK-----GVVIGTGENSEFGEVFKMM--QAEEAPKTPLQKSMDLL-----GKQLSFYSFgI 276
Cdd:cd07543 171 LFGGTKVvqhtppgKGGlKPPdggclAYVLRTGFETSQGKLLRTIlfSTERVTANNLETFIFILfllvfAIAAAAYVW-I 249
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 277 IGIIMlvGWLLGKDILEMFTISVSLavaaIPEGLPIvvtvTLALGV---MRMVKKRAIVKKLPI-VETLGCCNVICSDKT 352
Cdd:cd07543 250 EGTKD--GRSRYKLFLECTLILTSV----VPPELPM----ELSLAVntsLIALAKLYIFCTEPFrIPFAGKVDICCFDKT 319
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 353 GTLTKNEMtvthiftsdglhaEVTGV-GYNQFGEVIVDGDVVHGfynpavsRIVEAGCVCNDAVIR-NNTLMGKPTEGA- 429
Cdd:cd07543 320 GTLTSDDL-------------VVEGVaGLNDGKEVIPVSSIEPV-------ETILVLASCHSLVKLdDGKLVGDPLEKAt 379
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 430 LIALAMKMGLD--------GLQQDYIRKAeYPFSSEQKWMAVKCVHR--TQQDRPEICFMKGAYEqvikycttyqskgqt 499
Cdd:cd07543 380 LEAVDWTLTKDekvfprskKTKGLKIIQR-FHFSSALKRMSVVASYKdpGSTDLKYIVAVKGAPE--------------- 443
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 500 lTLTQQQRDV---YQQEKARMGSAGLRVLALASG--PELGQ--------------LTFLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:cd07543 444 -TLKSMLSDVpadYDEVYKEYTRQGSRVLALGYKelGHLTKqqardykredvesdLTFAGFIVFSCPLKPDSKETIKELN 522
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 561 ASGVSIKMITGDSQETAVAIASRLGLyskTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKIIKSLQKNGSVVA 640
Cdd:cd07543 523 NSSHRVVMITGDNPLTACHVAKELGI---VDKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFIITTLKELGYVTL 599
                       570       580
                ....*....|....*....|.
gi 48762689 641 MTGDGVNDAVALKAADIGVAM 661
Cdd:cd07543 600 MCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
71-742 2.71e-34

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 139.86  E-value: 2.71e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  71 LWKKYISQFKNPLIMLLLAS-AVI-SVLMHQFDDAVSitVAILIVVTVAfVQEY---RSEKSLEELSKLVPPECHCVREG 145
Cdd:cd07545  28 FKKGWRNLIRRNFDMKTLMTiAVIgAALIGEWPEAAM--VVFLFAISEA-LEAYsmdRARRSIRSLMDIAPKTALVRRDG 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 146 KLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSIDESSLTGETTPCSKvtapqpaaTNGDLAsrsniaFMGTLVRC 225
Cdd:cd07545 105 QEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGES-SVNQAAITGESLPVEK--------GVGDEV------FAGTLNGE 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 226 GKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSFGIIGIIMLVG----WLLGKDILEMFTISVSL 301
Cdd:cd07545 170 GALEVRVTKPAEDSTIARIIHLVEEAQAERAPTQAFVDRFAR---YYTPVVMAIAALVAivppLFFGGAWFTWIYRGLAL 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 302 AVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEmtvthiftsdglhaevtgvgyn 381
Cdd:cd07545 247 LVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGK---------------------- 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 382 qfgevivdgdvvhgfynPAVSRIVEAGCvcndavirnntlmgkPTEGALIALAMKMGldglqqdyiRKAEYPFSS----- 456
Cdd:cd07545 305 -----------------PVVTDVVVLGG---------------QTEKELLAIAAALE---------YRSEHPLASaivkk 343
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 457 -EQKWMAVKCVHrtqqdrpEICFMKGAYEQVIKYCTTYQSKGQTL--TLTQQQRDVYQQEKARMGSAGLRVLALASGPel 533
Cdd:cd07545 344 aEQRGLTLSAVE-------EFTALTGRGVRGVVNGTTYYIGSPRLfeELNLSESPALEAKLDALQNQGKTVMILGDGE-- 414
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 534 gqlTFLGLVGIIDPPRTGVKEAVTTLIASGVS-IKMITGDSQETAVAIASRLGLysktsQSVSGEEIdamdvqqlsqivp 612
Cdd:cd07545 415 ---RILGVIAVADQVRPSSRNAIAALHQLGIKqTVMLTGDNPQTAQAIAAQVGV-----SDIRAELL------------- 473
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 613 kvavfyrasPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:cd07545 474 ---------PQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLS 544
                       650       660       670       680       690
                ....*....|....*....|....*....|....*....|....*....|
gi 48762689 693 KGIYNNIKNFVRFQLSTSIAALTLIslatlmnFPnplnAMQILWINIIMD 742
Cdd:cd07545 545 RKTLAIIKQNIAFALGIKLIALLLV-------IP----GWLTLWMAVFAD 583
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
83-690 5.87e-34

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 138.61  E-value: 5.87e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  83 LIMLLLASAVISVLMHQFDDA------VSITVAILIVVTVAfVQEY----------------------RSEKSLEELSKL 134
Cdd:cd07544  29 IVLIGGVVIALSLLWEMIKTLrrgrygVDLLAILAIVATLL-VGEYwasliillmltggealedyaqrRASRELTALLDR 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 135 VPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLfEAVDLSIDESSLTGETTPCSKVTAPQ--PAATNGDLAs 212
Cdd:cd07544 108 APRIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEV-VSGTATLDESSLTGESKPVSKRPGDRvmSGAVNGDSA- 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 213 rsniafmgtlvrcgkAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGkqlsfYSFGIIGI-IMLVGWLLGKDI 291
Cdd:cd07544 186 ---------------LTMVATKLAADSQYAGIVRLVKEAQANPAPFVRLADRYA-----VPFTLLALaIAGVAWAVSGDP 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 292 lemfTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGL 371
Cdd:cd07544 246 ----VRFAAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDVVPAPGV 321
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 372 HA-EVTGVGYNqfgeviVDGDVVHgfynPAVSRIVEAGcvcndaviRNNTL-MGKPTEgalIALAMKMGLDG-LQQDYIR 448
Cdd:cd07544 322 DAdEVLRLAAS------VEQYSSH----VLARAIVAAA--------RERELqLSAVTE---LTEVPGAGVTGtVDGHEVK 380
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 449 KAEYPFSSEQKWMAvkcvhrtqqdrpeicfmkgayeqvikycttyqskgqtltltqqqrdvyqQEKARMGSAGLRVLALA 528
Cdd:cd07544 381 VGKLKFVLARGAWA-------------------------------------------------PDIRNRPLGGTAVYVSV 411
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 529 SGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVS-IKMITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqql 607
Cdd:cd07544 412 DG------KYAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGI-----DEVRAE---------- 470
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 608 sqivpkvavfyrASPRHKMKIIKSLQKNGsVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMS 687
Cdd:cd07544 471 ------------LLPEDKLAAVKEAPKAG-PTIMVGDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDLDRVVD 537

                ...
gi 48762689 688 AIE 690
Cdd:cd07544 538 AVA 540
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
78-735 8.12e-33

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 135.85  E-value: 8.12e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  78 QFKNPLIMLLLASAVISVLMHQFDDAVS--------ITVAILIVVTVAF------VQEYRSE---KSL-----EELSKLV 135
Cdd:cd02078  21 LAKNPVMFVVEIGSIITTVLTFFPLLFSgggpagfnLAVSLWLWFTVLFanfaeaIAEGRGKaqaDSLrktktETQAKRL 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 136 ppechcVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKVTAPQPAATNGdlasrsn 215
Cdd:cd02078 101 ------RNDGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPVIRESGGDRSSVTG------- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 216 iafmGTLVRCGKAKGVVigtgeNSEFGEVF--KMMQAEEAP---KTPLQKSMDllgkqlsfysfgiigiIMLVGwllgkd 290
Cdd:cd02078 167 ----GTKVLSDRIKVRI-----TANPGETFldRMIALVEGAsrqKTPNEIALT----------------ILLVG------ 215
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 291 ilemFTISVSLAVAAIP-----EGLPIVVTVTLAL-------------------GVMRMVKKRAIVKKLPIVETLGCCNV 346
Cdd:cd02078 216 ----LTLIFLIVVATLPpfaeySGAPVSVTVLVALlvclipttiggllsaigiaGMDRLLRFNVIAKSGRAVEAAGDVDT 291
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 347 ICSDKTGTLT-KNEMTVTHIftsdglhaEVTGVGYNQFGEVivdgdvvhgfynpavsriveagcvCNDAVIRNNTLMGKp 425
Cdd:cd02078 292 LLLDKTGTITlGNRQATEFI--------PVGGVDEKELADA------------------------AQLASLADETPEGR- 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 426 tegALIALAMKMGLDGLQQDYiRKAEY-PFSSEQKWMAVKCVHRTQqdrpeicFMKGAYEQVIKYCTTYQSKgqtltLTQ 504
Cdd:cd02078 339 ---SIVILAKQLGGTERDLDL-SGAEFiPFSAETRMSGVDLPDGTE-------IRKGAVDAIRKYVRSLGGS-----IPE 402
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 505 QQRDVYQqEKARMGSAGLRVLALAsgpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRL 584
Cdd:cd02078 403 ELEAIVE-EISKQGGTPLVVAEDD--------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEA 473
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 585 GLYSKTSQsvsgeeidamdvqqlsqivpkvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQT 664
Cdd:cd02078 474 GVDDFLAE---------------------------AKPEDKLELIRKEQAKGKLVAMTGDGTNDAPALAQADVGVAM-NS 525
                       650       660       670       680       690       700       710
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 48762689 665 GTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:cd02078 526 GTQAAKEAGNMVDLDSDPTKLIEVVEIGKQLLMTRGALTTFSIANDVAKYFAIIPAMFAAAYPQLGALNIM 596
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
77-735 2.91e-28

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 121.91  E-value: 2.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    77 SQFKNPLIMLL----LASAVISVLMHQFDDA------VSITVAILIVVTVAF------VQEYRSEKSL--------EELS 132
Cdd:TIGR01497  28 AQWRNPVMFIVwvgsLLTTCITIAPASFGMPgnnlalFNAIITGILFITVLFanfaeaVAEGRGKAQAdslkgtkkTTFA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   133 KLVPPEchcvreGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKvtapqpaATNGDLAS 212
Cdd:TIGR01497 108 KLLRDD------GAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIK-------ESGGDFAS 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   213 RSNiafmGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIl 292
Cdd:TIGR01497 174 VTG----GTRILSDWLVVECTANPGETFLDRMIALVEGAQRRKTPNEIALTILLIALTLVFLLVTATLWPFAAYGGNAI- 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   293 eMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTknemtvthiftsdglh 372
Cdd:TIGR01497 249 -SVTVLVALLVCLIPTTIGGLLSAIGIAGMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTIT---------------- 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   373 aevtgVGYNQFGEVIVDGDVvhgfynpAVSRIVEAGCVCNdavIRNNTLMGKptegALIALAMKMGLDGLQQDYIRKAEY 452
Cdd:TIGR01497 312 -----LGNRLASEFIPAQGV-------DEKTLADAAQLAS---LADDTPEGK----SIVILAKQLGIREDDVQSLHATFV 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   453 PFSSEQKWMAVKCVHRTQqdrpeicFMKGAYEQVIKYCttyQSKGQTLTltqQQRDVYQQEKARMGSAGLrvlALASGPE 532
Cdd:TIGR01497 373 EFTAQTRMSGINLDNGRM-------IRKGAVDAIKRHV---EANGGHIP---TDLDQAVDQVARQGGTPL---VVCEDNR 436
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   533 LgqltfLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQsvsgeeidamdvqqlsqivp 612
Cdd:TIGR01497 437 I-----YGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGVDDFIAE-------------------- 491
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   613 kvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEG 692
Cdd:TIGR01497 492 -------ATPEDKIALIRQEQAEGKLVAMTGDGTNDAPALAQADVGVAM-NSGTQAAKEAANMVDLDSDPTKLIEVVHIG 563
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|...
gi 48762689   693 KGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:TIGR01497 564 KQLLITRGALTTFSIANDVAKYFAIIPAIFAAAYPQLQALNIM 606
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
123-700 3.03e-25

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 112.39  E-value: 3.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  123 RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTAPQ 202
Cdd:PRK11033 229 RARRGVSALMALVPETATRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVERATGEK 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  203 PAAtnGDLASRSniafmgtLVRCGkakgVVIGTGENSeFGEVFKMMQAEEAPKTPLQKSMDLLGKqlsFYSfgiiGIIML 282
Cdd:PRK11033 308 VPA--GATSVDR-------LVTLE----VLSEPGASA-IDRILHLIEEAEERRAPIERFIDRFSR---IYT----PAIML 366
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  283 VgwllgkdilemftisvSLAVAAIP-------------EGL---------------PIVVTVTLALGVMRmvkkRAIVKK 334
Cdd:PRK11033 367 V----------------ALLVILVPpllfaapwqewiyRGLtllligcpcalvistPAAITSGLAAAARR----GALIKG 426
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  335 LPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgEVIvdgdvvhgfynpAVSRIVEAGCvcnda 414
Cdd:PRK11033 427 GAALEQLGRVTTVAFDKTGTLTEGKPQVTDIHPATGISES----------ELL------------ALAAAVEQGS----- 479
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  415 virnntlmGKPTEGALIALAMKMGLDglqqdyirkaeYPFSSEQKWMAVKCVH-RTQQDRPEICfmkgayeqvikyctty 493
Cdd:PRK11033 480 --------THPLAQAIVREAQVRGLA-----------IPEAESQRALAGSGIEgQVNGERVLIC---------------- 524
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  494 qSKGQTLTLTQQQrdvyQQEKARMGSAG-LRVLALASGpelgqlTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGD 572
Cdd:PRK11033 525 -APGKLPPLADAF----AGQINELESAGkTVVLVLRND------DVLGLIALQDTLRADARQAISELKALGIKGVMLTGD 593
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  573 SQETAVAIASRLGlysktsqsvsgeeidaMDvqqlsqivpkvavfYRAS--PRHKMKIIKSLQKNgSVVAMTGDGVNDAV 650
Cdd:PRK11033 594 NPRAAAAIAGELG----------------ID--------------FRAGllPEDKVKAVTELNQH-APLAMVGDGINDAP 642
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 48762689  651 ALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIK 700
Cdd:PRK11033 643 AMKAASIGIAMG-SGTDVALETADAALTHNRLRGLAQMIELSRATHANIR 691
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
100-743 8.74e-25

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 110.30  E-value: 8.74e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 100 FDdavSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVRE---GKLEHTLARDLVPGDTVCLSVGDRVPADLRLF 176
Cdd:cd07553  91 FD---SLSVLVFLMLVGRWLQVVTQERNRNRLADSRLEAPITEIEtgsGSRIKTRADQIKSGDVYLVASGQRVPVDGKLL 167
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 177 EAvDLSIDESSLTGETTPCSKvtapqpaatngdlaSRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKT 256
Cdd:cd07553 168 SE-QASIDMSWLTGESLPRIV--------------ERGDKVPAGTSLENQAFEIRVEHSLAESWSGSILQKVEAQEARKT 232
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 257 PLqksmDLLGKQLSFYSFGIIGIIMLVGWL--LGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKK 334
Cdd:cd07553 233 PR----DLLADKIIHYFTVIALLIAVAGFGvwLAIDLSIALKVFTSVLIVACPCALALATPFTDEIALARLKKKGVLIKN 308
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 335 LPIVETLGCCNVICSDKTGTLTKNEMTVthiftsdglhaevtgvgynqfgeVIVDGDVVHGFYNPAVSRIVEAgcvCNDA 414
Cdd:cd07553 309 ASSLERLSRVRTIVFDKTGTLTRGKSSF-----------------------VMVNPEGIDRLALRAISAIEAH---SRHP 362
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 415 VIRnntlmgkptegALIALAMKMGLdglqqdyirkaeypfsseqkwmavkcvhrtqqDRPEICFMKgayEQVIKYCTTYQ 494
Cdd:cd07553 363 ISR-----------AIREHLMAKGL--------------------------------IKAGASELV---EIVGKGVSGNS 396
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 495 SKGQTltltqqqrdvyqqekaRMGSAGLRVLALASGPELGQLTFLGLVGII-DPPRTGVKEAVTTLIASGVSIKMITGDS 573
Cdd:cd07553 397 SGSLW----------------KLGSAPDACGIQESGVVIARDGRQLLDLSFnDLLRPDSNREIEELKKGGLSIAILSGDN 460
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 574 QETAVAIASRLGLysktsqsvsgeeidamDVQQLsqivpkvavFYRASPRHKMKIIKSLQKNGSVvaMTGDGVNDAVALK 653
Cdd:cd07553 461 EEKVRLVGDSLGL----------------DPRQL---------FGNLSPEEKLAWIESHSPENTL--MVGDGANDALALA 513
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 654 AADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTL-----IS---LATLMnf 725
Cdd:cd07553 514 SAFVGIAV-AGEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLalsgwISplvAAILM-- 590
                       650
                ....*....|....*...
gi 48762689 726 pnPLNAMQILWINIIMDG 743
Cdd:cd07553 591 --PLSSITILGIVWAALG 606
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
110-665 1.08e-23

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 107.64  E-value: 1.08e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 110 ILIVVTVAFVQE----YRSEKSLEELSKLvppECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS--- 182
Cdd:cd02073  55 LLFVLGVTAIKEgyedIRRHKSDNEVNNR---PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDglc 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 183 -IDESSLTGET------------TPCS---------KVTAPQPaatNGDLASrsniaFMGTLVRCGKAK----------- 229
Cdd:cd02073 132 yVETANLDGETnlkirqalpetaLLLSeedlarfsgEIECEQP---NNDLYT-----FNGTLELNGGRElplspdnlllr 203
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 230 -----------GVVIGTGENSefgevfKMMQaeEAPKTPLQKS-MDLLGKQLSFYSFGIIGIIMLVG-----WLLGKDIL 292
Cdd:cd02073 204 gctlrntewvyGVVVYTGHET------KLML--NSGGTPLKRSsIEKKMNRFIIAIFCILIVMCLISaigkgIWLSKHGR 275
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 293 EMFTISVSLAVAAIPEGLPIVVT--------VTLALGV-MRMVK-------------------KRAIVKKLPIVETLGCC 344
Cdd:cd02073 276 DLWYLLPKEERSPALEFFFDFLTfiilynnlIPISLYVtIEVVKflqsffinwdldmydeetdTPAEARTSNLNEELGQV 355
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 345 NVICSDKTGTLTKNEMTvthiftsdglhaevtgvgynqFGEVIVDGdVVHGFYnpavsrivEAGCVCNDAVIRNNTLMGK 424
Cdd:cd02073 356 EYIFSDKTGTLTENIME---------------------FKKCSING-VDYGFF--------LALALCHTVVPEKDDHPGQ 405
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 425 -------PTEGALIALAMKMG--LDGLQQDYI------RKAEY------PFSSEQKWMAVkcVHRTQQDRpeIC-FMKGA 482
Cdd:cd02073 406 lvyqassPDEAALVEAARDLGfvFLSRTPDTVtinalgEEEEYeilhilEFNSDRKRMSV--IVRDPDGR--ILlYCKGA 481
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 483 ----YEQVIKycttyqSKGQTLTLTQQQRDVYQQEkarmgsaGLRVLALA------------------------------ 528
Cdd:cd02073 482 dsviFERLSP------SSLELVEKTQEHLEDFASE-------GLRTLCLAyreiseeeyeewnekydeastalqnreell 548
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 529 --SGPELGQ-LTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVsGEEID----- 600
Cdd:cd02073 549 deVAEEIEKdLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDMENL-ALVIDgktlt 627
                       650       660       670       680       690       700       710
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48762689 601 -AMDVQQLSQIVP-----KVAVFYRASPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVA-MGQTG 665
Cdd:cd02073 628 yALDPELERLFLElalkcKAVICCRVSPLQKALVVKLVKKSKKAVTLAiGDGANDVSMIQEAHVGVGiSGQEG 700
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
100-690 1.49e-23

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 106.29  E-value: 1.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 100 FDDAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVR-EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEA 178
Cdd:cd02092  89 FDAAVMLLFFLLIGRYLDHRMRGRARSAAEELAALEARGAQRLQaDGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSG 168
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 179 VDLsIDESSLTGETtpcskvtAPQPAATNGDL-ASRSNIAfmGTL-VRcgkakgvVIGTGENSEFGEVFKMMQAEEAPKT 256
Cdd:cd02092 169 TSE-LDRSLLTGES-------APVTVAPGDLVqAGAMNLS--GPLrLR-------ATAAGDDTLLAEIARLMEAAEQGRS 231
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 257 plqKSMDLLGKQLSFYS--FGIIGIIMLVGW-LLGKDILEMFTISVSLAVAAIPEGL----PIVVTVtlALGvmRMVKKR 329
Cdd:cd02092 232 ---RYVRLADRAARLYApvVHLLALLTFVGWvAAGGDWRHALLIAVAVLIITCPCALglavPAVQVV--ASG--RLFRRG 304
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 330 AIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGvgynqfgevivdGDVVHGFYNPAVSRIVEAGC 409
Cdd:cd02092 305 VLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGAHAISADLLALAA------------ALAQASRHPLSRALAAAAGA 372
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 410 VcnDAVIRNNT-LMGKPTEGALIALAMKMGldglqqdyirkaeypfsseqkwmavkcvhrtqqdRPEICfmkGAYEQVIK 488
Cdd:cd02092 373 R--PVELDDAReVPGRGVEGRIDGARVRLG----------------------------------RPAWL---GASAGVST 413
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 489 YCTTYQSKGqtltltqqqrdvyQQEKARMGSAglrvlalasgpelgqltflglvgiiDPPRTGVKEAVTTLIASGVSIKM 568
Cdd:cd02092 414 ASELALSKG-------------GEEAARFPFE-------------------------DRPRPDAREAISALRALGLSVEI 455
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 569 ITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqqlsqivpkvavfyrASPRHKMKIIKSLQKNGSVVAMTGDGVND 648
Cdd:cd02092 456 LSGDREPAVRALARALGI-----EDWRAG----------------------LTPAEKVARIEELKAQGRRVLMVGDGLND 508
                       570       580       590       600
                ....*....|....*....|....*....|....*....|..
gi 48762689 649 AVALKAADIGVAMGqTGTDVCKEAADMILVDDDFQTIMSAIE 690
Cdd:cd02092 509 APALAAAHVSMAPA-SAVDASRSAADIVFLGDSLAPVPEAIE 549
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
144-735 1.75e-23

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 106.71  E-value: 1.75e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  144 EGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVdLSIDESSLTGETTPCSKvtapqpaATNGDLasrsNIAFMGTLV 223
Cdd:PRK14010 112 DGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKGL-ATVDESAITGESAPVIK-------ESGGDF----DNVIGGTSV 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  224 RCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDIleMFTISVSLAV 303
Cdd:PRK14010 180 ASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNEIALFTLLMTLTIIFLVVILTMYPLAKFLNFNL--SIAMLIALAV 257
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  304 AAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTknemtvthifTSDGLHAEVTGVGYNQF 383
Cdd:PRK14010 258 CLIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTIT----------YGNRMADAFIPVKSSSF 327
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  384 gevivdgdvvhgfynpavSRIVEAGCVCNdavIRNNTlmgkPTEGALIALAMKMGLDgLQQDyiRKAEYPFSSEQKWMAV 463
Cdd:PRK14010 328 ------------------ERLVKAAYESS---IADDT----PEGRSIVKLAYKQHID-LPQE--VGEYIPFTAETRMSGV 379
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  464 KCVHRTqqdrpeicFMKGAYEQVIKycTTYQSKGQtltlTQQQRDVYQQEKARMGSAGLRVLAlasgpelgQLTFLGLVG 543
Cdd:PRK14010 380 KFTTRE--------VYKGAPNSMVK--RVKEAGGH----IPVDLDALVKGVSKKGGTPLVVLE--------DNEILGVIY 437
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  544 IIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQsvsgeeidamdvqqlsqivpkvavfyrASPR 623
Cdd:PRK14010 438 LKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVDRFVAE---------------------------CKPE 490
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  624 HKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMgQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGIYNNIKNFV 703
Cdd:PRK14010 491 DKINVIREEQAKGHIVAMTGDGTNDAPALAEANVGLAM-NSGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLT 569
                        570       580       590
                 ....*....|....*....|....*....|..
gi 48762689  704 RFQLSTSIAALTLISLATLMNFPNPLNAMQIL 735
Cdd:PRK14010 570 TFSIANDIAKYFAILPAMFMAAMPAMNHLNIM 601
copA PRK10671
copper-exporting P-type ATPase CopA;
123-724 3.12e-22

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 102.90  E-value: 3.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  123 RSEKSLEELSKLVPPECHCV-REGKLEHTLArDLVPGDTVCLSVGDRVPADLRLFEAvDLSIDESSLTGETTPCSKVTap 201
Cdd:PRK10671 309 RSSKALEKLLDLTPPTARVVtDEGEKSVPLA-DVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGE-- 384
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  202 qpaatnGDlasrsnIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDllgKQLSFYSFGIIGIIM 281
Cdd:PRK10671 385 ------GD------SVHAGTVVQDGSVLFRASAVGSHTTLSRIIRMVRQAQSSKPEIGQLAD---KISAVFVPVVVVIAL 449
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  282 LVG--WLL---GKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLT 356
Cdd:PRK10671 450 VSAaiWYFfgpAPQIVYTLVIATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLT 529
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  357 KNEMTVTHIFTsdglhaevtgvgYNQFGEVIV---DGDVVHGFYNPAVSRIVE-AGCVCNDAVIRNNTLMGKPTEGALIA 432
Cdd:PRK10671 530 EGKPQVVAVKT------------FNGVDEAQAlrlAAALEQGSSHPLARAILDkAGDMTLPQVNGFRTLRGLGVSGEAEG 597
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  433 LAMKMGldglqqdyirkaeypfssEQKWMAvkcvhrtqqdrpeicfmkgayeqvikycttyqskgqtltltQQQRDV--Y 510
Cdd:PRK10671 598 HALLLG------------------NQALLN-----------------------------------------EQQVDTkaL 618
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  511 QQEKARMGSAGLRVLALASGpelGQLTflGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGlyskt 590
Cdd:PRK10671 619 EAEITAQASQGATPVLLAVD---GKAA--ALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAG----- 688
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  591 sqsvsgeeIDamdvqqlsQIVPKVAvfyrasPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGqTGTDVCK 670
Cdd:PRK10671 689 --------ID--------EVIAGVL------PDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAI 745
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKN-----FVRFQLSTSIAALTLISL-ATLMN 724
Cdd:PRK10671 746 ETAAITLMRHSLMGVADALAISRATLRNMKQnllgaFIYNSLGIPIAAGILWPFtGTLLN 805
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
409-493 2.50e-20

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 86.50  E-value: 2.50e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   409 CVCNDAVIRNN------TLMGKPTEGALIALAMKMGLD--GLQQDYIRKAEYPFSSEQKWMAVkcVHRTQQDRPEICFMK 480
Cdd:pfam13246   1 ALCNSAAFDENeekgkwEIVGDPTESALLVFAEKMGIDveELRKDYPRVAEIPFNSDRKRMST--VHKLPDDGKYRLFVK 78
                          90
                  ....*....|...
gi 48762689   481 GAYEQVIKYCTTY 493
Cdd:pfam13246  79 GAPEIILDRCTTI 91
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
26-93 2.20e-18

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 79.91  E-value: 2.20e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48762689    26 ASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVI 93
Cdd:pfam00690   1 WHALSVEEVLKKLGTDLEKGLTEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
29-97 2.68e-17

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 77.24  E-value: 2.68e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48762689     29 LPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLM 97
Cdd:smart00831   7 LSLEEVLERLQTDLEKGLSSEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
78-665 6.97e-17

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 85.90  E-value: 6.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689     78 QFKNPLIMLLLasaVISVLmhQFDDAVSIT------VAILIVVTVAFVQE----YRSEKS-LEELSKLVppecHCVRE-G 145
Cdd:TIGR01652   24 QFKRFANLYFL---VVALL--QQVPILSPTyrgtsiVPLAFVLIVTAIKEaiedIRRRRRdKEVNNRLT----EVLEGhG 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    146 KLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGET----------TPC-----------SKVTA 200
Cdd:TIGR01652   95 QFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvcyVETANLDGETnlklrqaleeTQKmldeddiknfsGEIEC 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    201 PQPAAT----NGDLA---------SRSNIAFMGTLVRCGK-AKGVVIGTGensefGEVFKMMQAEEAP--KTPLQKSMDL 264
Cdd:TIGR01652  175 EQPNASlysfQGNMTingdrqyplSPDNILLRGCTLRNTDwVIGVVVYTG-----HDTKLMRNATQAPskRSRLEKELNF 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    265 LGKQLSFYSFGIIgIIMLVG------------WLLGKDILEM---------FTISVSLAVAAIPEGLPI---VVTVTLAL 320
Cdd:TIGR01652  250 LIIILFCLLFVLC-LISSVGagiwndahgkdlWYIRLDVSERnaaangffsFLTFLILFSSLIPISLYVsleLVKSVQAY 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    321 ---GVMRMVKKR----AIVKKLPIVETLGCCNVICSDKTGTLTKNEM----------TVTHIFT--SDGLH--------- 372
Cdd:TIGR01652  329 finSDLQMYHEKtdtpASVRTSNLNEELGQVEYIFSDKTGTLTQNIMefkkcsiagvSYGDGFTeiKDGIRerlgsyven 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    373 ---AEVTGVGYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAV-IRNNTLMGK-------PTEGALIALAMKMGLD- 440
Cdd:TIGR01652  409 ensMLVESKGFTFVDPRLVDLLKTNKPNAKRINEFFLALALCHTVVpEFNDDGPEEityqaasPDEAALVKAARDVGFVf 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    441 ---------------GLQQDYIRKAEYPFSSEQKWMAVKCvhRTQQDRPEIcFMKGAYEQVIKYCTTYQSkgqtltltqQ 505
Cdd:TIGR01652  489 fertpksislliemhGETKEYEILNVLEFNSDRKRMSVIV--RNPDGRIKL-LCKGADTVIFKRLSSGGN---------Q 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    506 QRDVYQQEKARMGSAGLRVLALASgPELGQ----------------------------------LTFLGLVGIIDPPRTG 551
Cdd:TIGR01652  557 VNEETKEHLENYASEGLRTLCIAY-RELSEeeyeewneeyneastaltdreekldvvaesiekdLILLGATAIEDKLQEG 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    552 VKEAVTTLIASGVSIKMITGDSQETA--VAIASRL----------GLYSKTSQSVSGEEI-----DAMDVQQLSQIVPKV 614
Cdd:TIGR01652  636 VPETIELLRQAGIKIWVLTGDKVETAinIGYSCRLlsrnmeqiviTSDSLDATRSVEAAIkfgleGTSEEFNNLGDSGNV 715
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689    615 A------------------VFY------------RASPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVAM-G 662
Cdd:TIGR01652  716 AlvidgkslgyaldeelekEFLqlalkckaviccRVSPSQKADVVRLVKKSTGKTTLAiGDGANDVSMIQEADVGVGIsG 795

                   ...
gi 48762689    663 QTG 665
Cdd:TIGR01652  796 KEG 798
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
108-722 2.06e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 83.82  E-value: 2.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 108 VAILIVVTVA-FVQEY---RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDlSI 183
Cdd:cd07548  76 VAVMLFYEVGeLFQDLaveRSRKSIKALLDIRPDYANLKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGES-FL 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 184 DESSLTGETTPcskvtapqpaatnGDLASRSNIaFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMD 263
Cdd:cd07548 155 DTSALTGESVP-------------VEVKEGSSV-LAGFINLNGVLEIKVTKPFKDSAVAKILELVENASARKAPTEKFIT 220
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 264 LLGKqlsFYSFGIIGI---IMLVGWLLGKDilEMFTISVSLA----VAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLP 336
Cdd:cd07548 221 KFAR---YYTPIVVFLallLAVIPPLFSPD--GSFSDWIYRAlvflVISCPCALVISIPLGYFGGIGAASRKGILIKGSN 295
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 337 IVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEvtgvgynqfgevivdgDVVHgfynpaVSRIVEAGCvcndavi 416
Cdd:cd07548 296 YLEALSQVKTVVFDKTGTLTKGVFKVTEIVPAPGFSKE----------------ELLK------LAALAESNS------- 346
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 417 rnntlmGKPtegalIALAmkmgldglqqdyIRKAeypfsseqkwmavkCVHRTQQDRPEicfmkgAYEQVikycttyqsK 496
Cdd:cd07548 347 ------NHP-----IARS------------IQKA--------------YGKMIDPSEIE------DYEEI---------A 374
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 497 GQTLTLTQQQRDVYQQEKARMGSAGLR---------VLALASGpelgqLTFLGLVGIIDPPRTGVKEAVTTLIASGVS-I 566
Cdd:cd07548 375 GHGIRAVVDGKEILVGNEKLMEKFNIEhdedeiegtIVHVALD-----GKYVGYIVISDEIKEDAKEAIKGLKELGIKnL 449
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 567 KMITGDSQETAVAIASRLGLysktsQSVSGEeidamdvqqlsqIVP--KVAVFYRASPRHKMKiikslqkngsvVAMTGD 644
Cdd:cd07548 450 VMLTGDRKSVAEKVAKKLGI-----DEVYAE------------LLPedKVEKVEELKAESKGK-----------VAFVGD 501
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 645 GVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKG----IYNNIKnfvrFQLSTSIAALTL--IS 718
Cdd:cd07548 502 GINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAEAIKIARKtrriVWQNII----LALGVKAIVLILgaLG 577

                ....
gi 48762689 719 LATL 722
Cdd:cd07548 578 LATM 581
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
78-661 2.49e-16

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 83.80  E-value: 2.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689  78 QFKNPLIMLLLasaVISVLmhQFDDAVSIT------VAILIVVTVAFVQE----YRSEKSLEELSKlvpPECHCVREGKL 147
Cdd:cd07536  22 QFKRFLNLYFL---VIACL--QFVPALKPGylyttwAPLIFILAVTMTKEaiddFRRFQRDKEVNK---KQLYSKLTGRK 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 148 EHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGETTPCSKV--TAPQPAATNGDLASRS------- 214
Cdd:cd07536  94 VQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDLKLRVavSCTQQLPALGDLMKISayvecqk 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 215 ----------------------------NIAFMGT-LVRCGKAKGVVIGTGENSefgevfKMMQAEEAPKtPLQKSMDLL 265
Cdd:cd07536 174 pqmdihsfegnftledsdppiheslsieNTLLRAStLRNTGWVIGVVVYTGKET------KLVMNTSNAK-NKVGLLDLE 246
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 266 GKQLSFYSFGI---IGIIMLVGWLLGKD--------ILEMFTISVSLAVAAIPEGL------PIVVTVTLALG---VMRM 325
Cdd:cd07536 247 LNRLTKALFLAlvvLSLVMVTLQGFWGPwygeknwyIKKMDTTSDNFGRNLLRFLLlfsyiiPISLRVNLDMVkavYAWF 326
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 326 VKKR-----------AIVKKLPIVETLGCCNVICSDKTGTLTKNEMtvthIFTsdglHAEVTGVGYNqfGEVIVDGdvvh 394
Cdd:cd07536 327 IMWDenmyyigndtgTVARTSTIPEELGQVVYLLTDKTGTLTQNEM----IFK----RCHIGGVSYG--GQVLSFC---- 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 395 gfynpavsrIVEAgcvcndavirnntlmgkptegalialamkmgldglqqdyirkaeYPFSSEQKWMAVkcVHRTQQDRP 474
Cdd:cd07536 393 ---------ILQL--------------------------------------------LEFTSDRKRMSV--IVRDESTGE 417
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 475 EICFMKGAYEQVIKYCTTYQSKGQTL------------TLTQQQRD-----------VYQQEKARMGSAGLRVLALASGP 531
Cdd:cd07536 418 ITLYMKGADVAISPIVSKDSYMEQYNdwleeecgeglrTLCVAKKAlteneyqewesRYTEASLSLHDRSLRVAEVVESL 497
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 532 ElGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTS-----QSVSGEEIDAMDVQQ 606
Cdd:cd07536 498 E-RELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQdihllRQDTSRGERAAITQH 576
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 607 LS-----------------------------------QIVPKVAVFYRASPRHKMKIIKSLQK-NGSVVAMTGDGVNDAV 650
Cdd:cd07536 577 AHlelnafrrkhdvalvidgdslevalkyyrhefvelACQCPAVICCRVSPTQKARIVTLLKQhTGRRTLAIGDGGNDVS 656
                       730
                ....*....|.
gi 48762689 651 ALKAADIGVAM 661
Cdd:cd07536 657 MIQAADCGVGI 667
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
152-659 3.06e-15

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 80.53  E-value: 3.06e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 152 ARDLVPGDTVCLSVGDRVPADLRLFEAVDLS----IDESSLTGETTPCSKVTAP--QPAATNGDLASRS----------- 214
Cdd:cd07541  96 SSDIKVGDLIIVEKNQRIPADMVLLRTSEKSgscfIRTDQLDGETDWKLRIAVPctQKLPEEGILNSISavyaeapqkdi 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 215 ---------------------NIAFMGTLVRCGKAKGVVIGTGEnsefgEVFKMMQAEEaPKTP---LQKSMDLLGKQLS 270
Cdd:cd07541 176 hsfygtftinddptseslsveNTLWANTVVASGTVIGVVVYTGK-----ETRSVMNTSQ-PKNKvglLDLEINFLTKILF 249
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 271 FYSFGI-IGIIMLVGwLLGKDILEMFTIsvSLAVAAIpegLPIVVTVTLALGVM---RMVKK-----RAIVKKLPIVETL 341
Cdd:cd07541 250 CAVLALsIVMVALQG-FQGPWYIYLFRF--LILFSSI---IPISLRVNLDMAKIvysWQIEHdknipGTVVRTSTIPEEL 323
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 342 GCCNVICSDKTGTLTKNEMTVTHiftsdgLHaevtgVGYNQFGEVIVDGDVVHGFynpavsriveagcvcndavirnntl 421
Cdd:cd07541 324 GRIEYLLSDKTGTLTQNEMVFKK------LH-----LGTVSYGGQNLNYEILQIF------------------------- 367
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 422 mgkptegalialamkmgldglqqdyirkaeyPFSSEQKWMAVkcVHRTQQDRpEICF-MKGA---YEQVIKY-------C 490
Cdd:cd07541 368 -------------------------------PFTSESKRMGI--IVREEKTG-EITFyMKGAdvvMSKIVQYndwleeeC 413
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 491 TTYQSKG-QTLT-----LTQQQ----RDVYQQEKARMGSAGLRVLALASGPELGqLTFLGLVGIIDPPRTGVKEAVTTLI 560
Cdd:cd07541 414 GNMAREGlRTLVvakkkLSEEEyqafEKRYNAAKLSIHDRDLKVAEVVESLERE-LELLCLTGVEDKLQEDVKPTLELLR 492
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 561 ASGVSIKMITGDSQETAVAIASRLGLYSKTSQ----------------------------SVSGEEIDAM------DVQQ 606
Cdd:cd07541 493 NAGIKIWMLTGDKLETATCIAKSSKLVSRGQYihvfrkvttreeahlelnnlrrkhdcalVIDGESLEVClkyyehEFIE 572
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|....
gi 48762689 607 LSQIVPKVaVFYRASPRHKMKIIKSLQK-NGSVVAMTGDGVNDAVALKAADIGV 659
Cdd:cd07541 573 LACQLPAV-VCCRCSPTQKAQIVRLIQKhTGKRTCAIGDGGNDVSMIQAADVGV 625
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
539-656 6.34e-11

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 62.60  E-value: 6.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   539 LGLVGIIDP--PRTGVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIdamdvqqlsqivpkvaV 616
Cdd:pfam00702  88 LGVIALADElkLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDV----------------G 151
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 48762689   617 FYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAAD 656
Cdd:pfam00702 152 VGKPKPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAAG 191
PLN03190 PLN03190
aminophospholipid translocase; Provisional
284-665 5.38e-09

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 60.30  E-value: 5.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   284 GWllGKDILEMFTISVSLAVAAIPEGLPI---VVTVTLALGVMRMVK-------KRAIVKKLPIVETLGCCNVICSDKTG 353
Cdd:PLN03190  385 GW--GWEIFFTFLMSVIVFQIMIPISLYIsmeLVRVGQAYFMIRDDQmydeasnSRFQCRALNINEDLGQIKYVFSDKTG 462
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   354 TLTKNEM-----TVTHIFTSDG----------LHAEVTGVGYNQFGEVIVDGDVVH----GFYNPAVSRIVE-----AGC 409
Cdd:PLN03190  463 TLTENKMefqcaSIWGVDYSDGrtptqndhagYSVEVDGKILRPKMKVKVDPQLLElsksGKDTEEAKHVHDfflalAAC 542
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   410 ------VCNDAVIRNNTLMG----KPTEGALIALAMKMG--------------LDGLQQDYIRKAEYPFSSEQKWMAV-- 463
Cdd:PLN03190  543 ntivpiVVDDTSDPTVKLMDyqgeSPDEQALVYAAAAYGfmliertsghividIHGERQRFNVLGLHEFDSDRKRMSVil 622
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   464 KCVHRTQQdrpeiCFMKGA-----------YEQVIKYCT-----TYQSKGQTlTLTQQQRDVYQQE------------KA 515
Cdd:PLN03190  623 GCPDKTVK-----VFVKGAdtsmfsvidrsLNMNVIRATeahlhTYSSLGLR-TLVVGMRELNDSEfeqwhfsfeaasTA 696
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   516 RMGSAGLrVLALASGPElGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAVAI--------------- 580
Cdd:PLN03190  697 LIGRAAL-LRKVASNVE-NNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIgyssklltnkmtqii 774
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689   581 -------------------ASRLGLYSKTSQSVSGEEIDAMDV-------------------QQLSQIVPKVAVFY--RA 620
Cdd:PLN03190  775 insnskescrksledalvmSKKLTTVSGISQNTGGSSAAASDPvaliidgtslvyvldseleEQLFQLASKCSVVLccRV 854
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 48762689   621 SPRHKMKIIKSLQKNGSVVAMT-GDGVNDAVALKAADIGVAM-GQTG 665
Cdd:PLN03190  855 APLQKAGIVALVKNRTSDMTLAiGDGANDVSMIQMADVGVGIsGQEG 901
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
643-702 5.36e-05

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 45.29  E-value: 5.36e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48762689 643 GDGVNDAVALKAADIGVAMGQTGTDVcKEAADMIL--VDDDfqtimsaieegkGIYNNIKNF 702
Cdd:cd07517 164 GDGLNDIEMLEAVGIGIAMGNAHEEL-KEIADYVTkdVDED------------GILKALKHF 212
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
537-681 8.79e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 44.36  E-value: 8.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 537 TFLGLVGIIdPPRTgvKEAVTTLIASGVSIKMITGDSQETAVAIASRLGL------------YSKTSQSVSGEEIDAMDV 604
Cdd:COG0561  12 TLLNDDGEI-SPRT--KEALRRLREKGIKVVIATGRPLRSALPLLEELGLddplitsngaliYDPDGEVLYERPLDPEDV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 605 QQLSQIVPK----VAVFYRASPR---------HKMKIIKSLQK-----NGSVVAMtGDGVNDAVALKAADIGVAMGQtGT 666
Cdd:COG0561  89 REILELLREhglhLQVVVRSGPGfleilpkgvSKGSALKKLAErlgipPEEVIAF-GDSGNDLEMLEAAGLGVAMGN-AP 166
                       170
                ....*....|....*..
gi 48762689 667 DVCKEAADMIL--VDDD 681
Cdd:COG0561 167 PEVKAAADYVTgsNDED 183
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
624-681 1.33e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 44.57  E-value: 1.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48762689   624 HKMKIIKSLQKNGSV----VAMTGDGVNDAVALKAADIGVAMGqTGTDVCKEAADMI--LVDDD 681
Cdd:TIGR00099 188 SKGSALQSLAEALGIsledVIAFGDGMNDIEMLEAAGYGVAMG-NADEELKALADYVtdSNNED 250
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
627-681 9.73e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.84  E-value: 9.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 48762689   627 KIIKSLQKNGS-VVAMtGDGVNDAVALKAADIGVAMGQtGTDVCKEAADMIL--VDDD 681
Cdd:pfam08282 194 ALAKHLNISLEeVIAF-GDGENDIEMLEAAGLGVAMGN-ASPEVKAAADYVTdsNNED 249
HAD_like cd01427
Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily ...
552-661 2.48e-03

Haloacid dehalogenase-like hydrolases; The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others. This superfamily includes a variety of enzymes that catalyze the cleavage of substrate C-Cl, P-C, and P-OP bonds via nucleophilic substitution pathways. All of which use a nucleophilic aspartate in their phosphoryl transfer reaction. They catalyze nucleophilic substitution reactions at phosphorus or carbon centers, using a conserved Asp carboxylate in covalent catalysis. All members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. Members of this superfamily are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319763 [Multi-domain]  Cd Length: 106  Bit Score: 38.53  E-value: 2.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 552 VKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEidamdvqqlsqivpkvavFYRASPRHKMKIIKS 631
Cdd:cd01427  12 AVELLKRLRAAGIKLAIVTNRSREALRALLEKLGLGDLFDGIIGSDG------------------GGTPKPKPKPLLLLL 73
                        90       100       110
                ....*....|....*....|....*....|...
gi 48762689 632 LQKNGS--VVAMTGDGVNDAVALKAA-DIGVAM 661
Cdd:cd01427  74 LKLGVDpeEVLFVGDSENDIEAARAAgGRTVAV 106
Gph COG0546
Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];
551-691 5.69e-03

Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion];


Pssm-ID: 440312 [Multi-domain]  Cd Length: 214  Bit Score: 39.14  E-value: 5.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762689 551 GVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEidamdvqqlsqivpkvavFYRASPRHKM--KI 628
Cdd:COG0546  88 GVRELLEALKARGIKLAVVTNKPREFAERLLEALGLDDYFDAIVGGDD------------------VPPAKPKPEPllEA 149
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48762689 629 IKSLQKNGSVVAMTGDGVNDAVALKAAD---IGVAMG-QTGTDVCKEAADMILvdDDFQTIMSAIEE 691
Cdd:COG0546 150 LERLGLDPEEVLMVGDSPHDIEAARAAGvpfIGVTWGyGSAEELEAAGADYVI--DSLAELLALLAE 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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