NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|48762744|ref|NP_001001580|]
View 

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j [Homo sapiens]

Protein Classification

3',5'-cyclic nucleotide phosphodiesterase( domain architecture ID 10446396)

3',5'-cyclic nucleotide phosphodiesterase catalyzes the hydrolysis of cAMP or cGMP to produce adenosine 5'-phosphate or guanosine 5'-phosphate, respectively

CATH:  1.10.1300.10
EC:  3.1.4.-
Gene Ontology:  GO:0046872|GO:0004114
PubMed:  11008484|9868367
SCOP:  4001423

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
94-322 4.69e-119

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 425542  Cd Length: 235  Bit Score: 344.12  E-value: 4.69e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744    94 FHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 173
Cdd:pfam00233   1 YHNFRHAADVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLINTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744   174 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKMILIKCCDISNEVR 251
Cdd:pfam00233  81 QILSSEECNIFSNLSKEEYKEVRKLIISLILATDMAKHFELLKKFKSLLDKtlDLENEEDRRLLLLQMLIKAADISNPTR 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48762744   252 PMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK-VTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM 322
Cdd:pfam00233 161 PWEISKKWAERVAEEFFRQGDLEKELGLPVSPLMDREKkTSLPKSQIGFIDFIVLPLFEALARLLPELQPLL 232
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
94-322 4.69e-119

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 425542  Cd Length: 235  Bit Score: 344.12  E-value: 4.69e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744    94 FHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 173
Cdd:pfam00233   1 YHNFRHAADVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLINTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744   174 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKMILIKCCDISNEVR 251
Cdd:pfam00233  81 QILSSEECNIFSNLSKEEYKEVRKLIISLILATDMAKHFELLKKFKSLLDKtlDLENEEDRRLLLLQMLIKAADISNPTR 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48762744   252 PMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK-VTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM 322
Cdd:pfam00233 161 PWEISKKWAERVAEEFFRQGDLEKELGLPVSPLMDREKkTSLPKSQIGFIDFIVLPLFEALARLLPELQPLL 232
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
95-268 2.53e-15

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 72.37  E-value: 2.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744  95 HNFRHCFCVAQMMYSMvwlcSLQEKFSQTDILILMTAAICHDLDHPGYNNTYqinartelavrYNDISPLENHHCAVAFQ 174
Cdd:cd00077   2 HRFEHSLRVAQLARRL----AEELGLSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAE 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744 175 ILAEPEcnifsnippdgFKQIRQGMITLILATDmARHAEIMDSFKEKMENfdysNEEHMTLLKMIlIKCCDISNEVRPM- 253
Cdd:cd00077  67 ILRELL-----------LEEVIKLIDELILAVD-ASHHERLDGLGYPDGL----KGEEITLEARI-VKLADRLDALRRDs 129
                       170
                ....*....|....*.
gi 48762744 254 -EVAEPWVDCLLEEYF 268
Cdd:cd00077 130 rEKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
92-259 1.90e-10

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 58.08  E-value: 1.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744     92 NPFHNFRHCFCVAQMMYSmvwlcsLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINartelavryndISPLENHHCAV 171
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAA------LAEELGLLDIELLLLAALLHDIGKPGTPDSFLVK-----------TSVLEDHHFIG 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744    172 AFQILAEPECNIFSNippdgfkqirqgmitlILATDMARHaeimdsfkekMENFDYSNEEHMTLLKMIlIKCCDISNEVR 251
Cdd:smart00471  64 AEILLEEEEPRILEE----------------ILRTAILSH----------HERPDGLRGEPITLEARI-VKVADRLDALR 116

                   ....*...
gi 48762744    252 PMEVAEPW 259
Cdd:smart00471 117 ADRRYRRV 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
94-322 4.69e-119

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 425542  Cd Length: 235  Bit Score: 344.12  E-value: 4.69e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744    94 FHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAF 173
Cdd:pfam00233   1 YHNFRHAADVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLINTKSPLAILYNDSSVLENHHCATAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744   174 QILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMEN--FDYSNEEHMTLLKMILIKCCDISNEVR 251
Cdd:pfam00233  81 QILSSEECNIFSNLSKEEYKEVRKLIISLILATDMAKHFELLKKFKSLLDKtlDLENEEDRRLLLLQMLIKAADISNPTR 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48762744   252 PMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDK-VTKATAQIGFIKFVLIPMFETVTKLFPMVEEIM 322
Cdd:pfam00233 161 PWEISKKWAERVAEEFFRQGDLEKELGLPVSPLMDREKkTSLPKSQIGFIDFIVLPLFEALARLLPELQPLL 232
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
95-268 2.53e-15

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 72.37  E-value: 2.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744  95 HNFRHCFCVAQMMYSMvwlcSLQEKFSQTDILILMTAAICHDLDHPGYNNTYqinartelavrYNDISPLENHHCAVAFQ 174
Cdd:cd00077   2 HRFEHSLRVAQLARRL----AEELGLSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAE 66
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744 175 ILAEPEcnifsnippdgFKQIRQGMITLILATDmARHAEIMDSFKEKMENfdysNEEHMTLLKMIlIKCCDISNEVRPM- 253
Cdd:cd00077  67 ILRELL-----------LEEVIKLIDELILAVD-ASHHERLDGLGYPDGL----KGEEITLEARI-VKLADRLDALRRDs 129
                       170
                ....*....|....*.
gi 48762744 254 -EVAEPWVDCLLEEYF 268
Cdd:cd00077 130 rEKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
92-259 1.90e-10

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 58.08  E-value: 1.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744     92 NPFHNFRHCFCVAQMMYSmvwlcsLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINartelavryndISPLENHHCAV 171
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAA------LAEELGLLDIELLLLAALLHDIGKPGTPDSFLVK-----------TSVLEDHHFIG 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48762744    172 AFQILAEPECNIFSNippdgfkqirqgmitlILATDMARHaeimdsfkekMENFDYSNEEHMTLLKMIlIKCCDISNEVR 251
Cdd:smart00471  64 AEILLEEEEPRILEE----------------ILRTAILSH----------HERPDGLRGEPITLEARI-VKVADRLDALR 116

                   ....*...
gi 48762744    252 PMEVAEPW 259
Cdd:smart00471 117 ADRRYRRV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH