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Conserved domains on  [gi|51558688|ref|NP_001003940|]
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bcl-2-modifying factor isoform bmf-1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BMF super family cl21050
Bcl-2-modifying factor, apoptosis; BMF is thought to play a role in inducing apoptosis. It is ...
2-184 1.60e-50

Bcl-2-modifying factor, apoptosis; BMF is thought to play a role in inducing apoptosis. It is thought to bind to Bcl-2 proteins. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.


The actual alignment was detected with superfamily member pfam15185:

Pssm-ID: 291841  Cd Length: 224  Bit Score: 162.42  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51558688     2 EPSQCVEELEDDVFQPEDGEPVT-QPGSLLSADLFAQSL-LDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPS 79
Cdd:pfam15185   8 EDLRNKDGEDDDAFGGDDFGLAHgHAGEMTAGGIFNQAQdADCLLGRFQLFPLTHCCGPGMAHFEGQDKAAQSLCPSSGA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51558688    80 QG-------------VMLPCGVTEEPQRLFYGNAGYRLPL-PASFPAVLPIGEQPPEGQWQH--------------QAEV 131
Cdd:pfam15185  88 QTafrapcgtgglvdLMLGCGAREEPRALFHGNAGFRAHFpPAGFALALDGLEEAEEGEQDEgrpeekeedrdaeaRTEV 167
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 51558688   132 QIARKLQCIADQFHR----LHVQQHQQNQNRVWWQILLFLHNLALNGEENRNGAGPR 184
Cdd:pfam15185 168 QIARKLQCIADQFHQehiqLVRVIHQQNRNQVIRLIFFFLHNLALNVEANRKAAGFQ 224
 
Name Accession Description Interval E-value
BMF pfam15185
Bcl-2-modifying factor, apoptosis; BMF is thought to play a role in inducing apoptosis. It is ...
2-184 1.60e-50

Bcl-2-modifying factor, apoptosis; BMF is thought to play a role in inducing apoptosis. It is thought to bind to Bcl-2 proteins. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.


Pssm-ID: 291841  Cd Length: 224  Bit Score: 162.42  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51558688     2 EPSQCVEELEDDVFQPEDGEPVT-QPGSLLSADLFAQSL-LDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPS 79
Cdd:pfam15185   8 EDLRNKDGEDDDAFGGDDFGLAHgHAGEMTAGGIFNQAQdADCLLGRFQLFPLTHCCGPGMAHFEGQDKAAQSLCPSSGA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51558688    80 QG-------------VMLPCGVTEEPQRLFYGNAGYRLPL-PASFPAVLPIGEQPPEGQWQH--------------QAEV 131
Cdd:pfam15185  88 QTafrapcgtgglvdLMLGCGAREEPRALFHGNAGFRAHFpPAGFALALDGLEEAEEGEQDEgrpeekeedrdaeaRTEV 167
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 51558688   132 QIARKLQCIADQFHR----LHVQQHQQNQNRVWWQILLFLHNLALNGEENRNGAGPR 184
Cdd:pfam15185 168 QIARKLQCIADQFHQehiqLVRVIHQQNRNQVIRLIFFFLHNLALNVEANRKAAGFQ 224
 
Name Accession Description Interval E-value
BMF pfam15185
Bcl-2-modifying factor, apoptosis; BMF is thought to play a role in inducing apoptosis. It is ...
2-184 1.60e-50

Bcl-2-modifying factor, apoptosis; BMF is thought to play a role in inducing apoptosis. It is thought to bind to Bcl-2 proteins. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.


Pssm-ID: 291841  Cd Length: 224  Bit Score: 162.42  E-value: 1.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51558688     2 EPSQCVEELEDDVFQPEDGEPVT-QPGSLLSADLFAQSL-LDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPS 79
Cdd:pfam15185   8 EDLRNKDGEDDDAFGGDDFGLAHgHAGEMTAGGIFNQAQdADCLLGRFQLFPLTHCCGPGMAHFEGQDKAAQSLCPSSGA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51558688    80 QG-------------VMLPCGVTEEPQRLFYGNAGYRLPL-PASFPAVLPIGEQPPEGQWQH--------------QAEV 131
Cdd:pfam15185  88 QTafrapcgtgglvdLMLGCGAREEPRALFHGNAGFRAHFpPAGFALALDGLEEAEEGEQDEgrpeekeedrdaeaRTEV 167
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 51558688   132 QIARKLQCIADQFHR----LHVQQHQQNQNRVWWQILLFLHNLALNGEENRNGAGPR 184
Cdd:pfam15185 168 QIARKLQCIADQFHQehiqLVRVIHQQNRNQVIRLIFFFLHNLALNVEANRKAAGFQ 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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