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Conserved domains on  [gi|52345394|ref|NP_001004365|]
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actin-related protein 3B isoform 1 [Mus musculus]

Protein Classification

actin-related protein 3( domain architecture ID 1003867)

actin-related protein 3 (ACTR3) is an ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00280 super family cl29668
Actin-related protein 3; Provisional
2-417 0e+00

Actin-related protein 3; Provisional


The actual alignment was detected with superfamily member PTZ00280:

Pssm-ID: 240343  Cd Length: 414  Bit Score: 718.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    2 AGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVvdqaqRRVLRGVDDLDFFIGDEAIDKP-TYATKWPIRH 80
Cdd:PTZ00280   1 ASTLPVVVIDNGTGYTKMGYAGNTEPTYIIPTLIADNSKQSR-----RRSKKGFEDLDFYIGDEALAASkSYTLTYPMKH 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   81 GIVEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGE 160
Cdd:PTZ00280  76 GIVEDWDLMEKFWEQCIFKYLRCEPEEHYFILTEPPMNPPENREYTAEIMFETFNVKGLYIAVQAVLALRASWTSKKAKE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  161 R--TLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDI 238
Cdd:PTZ00280 156 LggTLTGTVIDSGDGVTHVIPVVDGYVIGSSIKHIPLAGRDITNFIQQMLRERGEPIPAEDILLLAQRIKEKYCYVAPDI 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  239 VREFAKYDVDPRKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQSCPIDVRRPLYKN 318
Cdd:PTZ00280 236 AKEFEKYDSDPKNHFKKYTAVNSVTKKPYTVDVGYERFLGPEMFFHPEIFSSEWTTPLPEVVDDAIQSCPIDCRRPLYKN 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  319 VVLSGGSTMFRDFGRRLQRDLKRVVDARLKLSQELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKK 398
Cdd:PTZ00280 316 IVLSGGSTMFKGFDKRLQRDVRKRVDRRLKKAEELSGGKLKPIPIDVNVVSHPRQRYAVWYGGSMLASSPEFEKVCHTKA 395
                        410
                 ....*....|....*....
gi 52345394  399 DYEEYGPSICRHNPVFGVM 417
Cdd:PTZ00280 396 EYDEYGPSICRYNNVFHSV 414
 
Name Accession Description Interval E-value
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
2-417 0e+00

Actin-related protein 3; Provisional


Pssm-ID: 240343  Cd Length: 414  Bit Score: 718.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    2 AGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVvdqaqRRVLRGVDDLDFFIGDEAIDKP-TYATKWPIRH 80
Cdd:PTZ00280   1 ASTLPVVVIDNGTGYTKMGYAGNTEPTYIIPTLIADNSKQSR-----RRSKKGFEDLDFYIGDEALAASkSYTLTYPMKH 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   81 GIVEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGE 160
Cdd:PTZ00280  76 GIVEDWDLMEKFWEQCIFKYLRCEPEEHYFILTEPPMNPPENREYTAEIMFETFNVKGLYIAVQAVLALRASWTSKKAKE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  161 R--TLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDI 238
Cdd:PTZ00280 156 LggTLTGTVIDSGDGVTHVIPVVDGYVIGSSIKHIPLAGRDITNFIQQMLRERGEPIPAEDILLLAQRIKEKYCYVAPDI 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  239 VREFAKYDVDPRKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQSCPIDVRRPLYKN 318
Cdd:PTZ00280 236 AKEFEKYDSDPKNHFKKYTAVNSVTKKPYTVDVGYERFLGPEMFFHPEIFSSEWTTPLPEVVDDAIQSCPIDCRRPLYKN 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  319 VVLSGGSTMFRDFGRRLQRDLKRVVDARLKLSQELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKK 398
Cdd:PTZ00280 316 IVLSGGSTMFKGFDKRLQRDVRKRVDRRLKKAEELSGGKLKPIPIDVNVVSHPRQRYAVWYGGSMLASSPEFEKVCHTKA 395
                        410
                 ....*....|....*....
gi 52345394  399 DYEEYGPSICRHNPVFGVM 417
Cdd:PTZ00280 396 EYDEYGPSICRYNNVFHSV 414
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
6-412 1.73e-153

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 438.62  E-value: 1.73e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394      6 PPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAiresakvvdQAQRRVLRGVDDLDFFIGDEAIDKPTYAT-KWPIRHGIVE 84
Cdd:smart00268   2 PAIVIDNGSGTIKAGFAGEDFPQVVFPSIVG---------RPKDGKGMVGDAKDIFVGDEAQEKRGGLElKYPIENGIVE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394     85 DWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSrqvgertlT 164
Cdd:smart00268  73 NWDDMEKIWDYTFFNELRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRT--------T 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    165 GIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVREFAK 244
Cdd:smart00268 145 GLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDFEKEMKL 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    245 YDvdpRKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFmESISDVVDEVIQSCPIDVRRPLYKNVVLSGG 324
Cdd:smart00268 225 AR---ESSESSKLEKTYELPDGNTIKVGNERFRIPEILFSPELIGLEQ-KGIHELVYESIQKCDIDVRKDLYENIVLSGG 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    325 STMFRDFGRRLQRDLKRVVdarlklsqelsggrikPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYG 404
Cdd:smart00268 301 STLIPGFGERLEKELKQLA----------------PKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMWITKKEYEESG 364

                   ....*...
gi 52345394    405 PSICRHNP 412
Cdd:smart00268 365 SQIVERKC 372
COG5277 COG5277
Actin-related protein [Cytoskeleton];
1-410 6.17e-105

Actin-related protein [Cytoskeleton];


Pssm-ID: 227602 [Multi-domain]  Cd Length: 444  Bit Score: 317.44  E-value: 6.17e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   1 MAGSLPPCVV-DCGTGYTKLGYAGNTEPQFIIPSCIAIRESakvvdqaQRRVLRGVDDLDFFIGDEA---IDKPTYATKW 76
Cdd:COG5277   1 MTGDNVPTIViDNGSGTTKAGFAGNDTPTTVFPSIVGRRRD-------EDSVMEDTEEKDTYVGNEAqndRDNSLLELRY 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  77 PIRHGIVEDWDLMERFMEQVVFK--YLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWT 154
Cdd:COG5277  74 PIENGIILNWDAMEQIWDYTFFNkgDLLPSPEEHPLLLTEPPLNPPSNREKITELLFETLNVPALYLAIQAVLSLYASGS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 155 SrqvgerTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIP--------PEQSLETAKA 226
Cdd:COG5277 154 S------DETGLVIDSGDSVTHVIPVVDGIVLPKAVKRIDIGGRDITDYLKKLLREKYPPSRgynlkselVEYSSEIVNE 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 227 IKEKYC-------YICPDIVREFAKYDVDPRKWIKQYTGIN----AINQKKFI------IDVGYE-RFLGPEIFFHPE-- 286
Cdd:COG5277 228 IKEEVCetddesaYVSLDAEEEFEEEEEKPAEKSTESTFQLsketSIAKESKElpdgeeIEFGNEeRFKAPEILFKPElp 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 287 ------------------FANPDFMES--------ISDVVDEVIQSCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLK 340
Cdd:COG5277 308 isgleeagkideskqelvAENYEISPTnlgndiagLPELVYQSIQICDEDVRKSLYSNIVLTGGTSKIPGFAERLQKELT 387
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 341 rvvdarlklsqelsggRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRH 410
Cdd:COG5277 388 ----------------SLAPSIWKVSVIPPPDPSLDAWLGASILASLETFQQLWITKEEYEEHGPDILQE 441
Actin pfam00022
Actin;
6-409 7.06e-97

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 295.75  E-value: 7.06e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394     6 PPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVVDqaqrrvlrgvdDLDFFIGDEAIDK-PTYATKWPIRHGIVE 84
Cdd:pfam00022   2 SALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPRGTKVEA-----------ANKYYVGDEALTYrPGMEVRSPVEDGIVV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    85 DWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIavqavlALAASWTSRQVGeRTlT 164
Cdd:pfam00022  71 DWDAMEEIWEHVLKEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYL------AKNPVLSAFASG-RT-T 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   165 GIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKA------------------ 226
Cdd:pfam00022 143 GLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKPgdpapavtkrelpdttys 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   227 ------------IKEKYCYICPDIVREFAKYdvdprkwikqytgiNAINQKKFI------IDVGYERFLGPEIFFHPEFA 288
Cdd:pfam00022 223 yktyqerrvleeIKESVCYVSDDPFGDETTS--------------SSIPTRVYElpdgstIILGAERFRVPEILFNPSLI 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   289 NPD-------FMESISDVVDEVIQSCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVdarlklsqeLSGGRIKPK 361
Cdd:pfam00022 289 GSEselpppqTAVGIPELIVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLA---------PPGVKVKII 359
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 52345394   362 PVEVQVVThhmqRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICR 409
Cdd:pfam00022 360 APGNTVER----RYSAWIGGSILASLGTFQQMWVSKQEYEEHGASVVE 403
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
9-196 9.61e-11

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 60.68  E-value: 9.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   9 VVDCGTGYTKLGYA---GNTEPQFIIPSCIAIResakvvdqaqrrvlrgvddldffigdeaidkptyatkwpirhGIVED 85
Cdd:cd00012   2 GIDIGSTSTKAGVAdldGEILPEEIVPTPVGRP------------------------------------------GAVTD 39
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  86 WDLMERFMEQVVFKYLR-AEPEDHYFLMTEPPLNTPENREYL---------AEIMFESFNVPGLYIAVQAVLALAaswTS 155
Cdd:cd00012  40 LDELEEALRELLKEALRqLKSEIDAVGITEPGGVPKENREVIilpnlllipLALALEDLGGVPVAVVNDAVAAAL---AE 116
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 52345394 156 RQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIA 196
Cdd:cd00012 117 GLFGKEEDTVLVVDLGTGTTGIAIVEDGKGGVGAAGELGIA 157
 
Name Accession Description Interval E-value
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
2-417 0e+00

Actin-related protein 3; Provisional


Pssm-ID: 240343  Cd Length: 414  Bit Score: 718.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    2 AGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVvdqaqRRVLRGVDDLDFFIGDEAIDKP-TYATKWPIRH 80
Cdd:PTZ00280   1 ASTLPVVVIDNGTGYTKMGYAGNTEPTYIIPTLIADNSKQSR-----RRSKKGFEDLDFYIGDEALAASkSYTLTYPMKH 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   81 GIVEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGE 160
Cdd:PTZ00280  76 GIVEDWDLMEKFWEQCIFKYLRCEPEEHYFILTEPPMNPPENREYTAEIMFETFNVKGLYIAVQAVLALRASWTSKKAKE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  161 R--TLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDI 238
Cdd:PTZ00280 156 LggTLTGTVIDSGDGVTHVIPVVDGYVIGSSIKHIPLAGRDITNFIQQMLRERGEPIPAEDILLLAQRIKEKYCYVAPDI 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  239 VREFAKYDVDPRKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQSCPIDVRRPLYKN 318
Cdd:PTZ00280 236 AKEFEKYDSDPKNHFKKYTAVNSVTKKPYTVDVGYERFLGPEMFFHPEIFSSEWTTPLPEVVDDAIQSCPIDCRRPLYKN 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  319 VVLSGGSTMFRDFGRRLQRDLKRVVDARLKLSQELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKK 398
Cdd:PTZ00280 316 IVLSGGSTMFKGFDKRLQRDVRKRVDRRLKKAEELSGGKLKPIPIDVNVVSHPRQRYAVWYGGSMLASSPEFEKVCHTKA 395
                        410
                 ....*....|....*....
gi 52345394  399 DYEEYGPSICRHNPVFGVM 417
Cdd:PTZ00280 396 EYDEYGPSICRYNNVFHSV 414
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
6-412 1.73e-153

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 438.62  E-value: 1.73e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394      6 PPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAiresakvvdQAQRRVLRGVDDLDFFIGDEAIDKPTYAT-KWPIRHGIVE 84
Cdd:smart00268   2 PAIVIDNGSGTIKAGFAGEDFPQVVFPSIVG---------RPKDGKGMVGDAKDIFVGDEAQEKRGGLElKYPIENGIVE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394     85 DWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSrqvgertlT 164
Cdd:smart00268  73 NWDDMEKIWDYTFFNELRVEPEEHPVLLTEPPMNPKSNREKILEIMFETFNFPALYIAIQAVLSLYASGRT--------T 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    165 GIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVREFAK 244
Cdd:smart00268 145 GLVIDSGDGVTHVVPVVDGYVLPHAIKRIDIAGRDITDYLKELLSERGYQFNSSAEFEIVREIKEKLCYVAEDFEKEMKL 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    245 YDvdpRKWIKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFmESISDVVDEVIQSCPIDVRRPLYKNVVLSGG 324
Cdd:smart00268 225 AR---ESSESSKLEKTYELPDGNTIKVGNERFRIPEILFSPELIGLEQ-KGIHELVYESIQKCDIDVRKDLYENIVLSGG 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    325 STMFRDFGRRLQRDLKRVVdarlklsqelsggrikPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYG 404
Cdd:smart00268 301 STLIPGFGERLEKELKQLA----------------PKKLKVKVIAPPERKYSVWLGGSILASLSTFEDMWITKKEYEESG 364

                   ....*...
gi 52345394    405 PSICRHNP 412
Cdd:smart00268 365 SQIVERKC 372
COG5277 COG5277
Actin-related protein [Cytoskeleton];
1-410 6.17e-105

Actin-related protein [Cytoskeleton];


Pssm-ID: 227602 [Multi-domain]  Cd Length: 444  Bit Score: 317.44  E-value: 6.17e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   1 MAGSLPPCVV-DCGTGYTKLGYAGNTEPQFIIPSCIAIRESakvvdqaQRRVLRGVDDLDFFIGDEA---IDKPTYATKW 76
Cdd:COG5277   1 MTGDNVPTIViDNGSGTTKAGFAGNDTPTTVFPSIVGRRRD-------EDSVMEDTEEKDTYVGNEAqndRDNSLLELRY 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  77 PIRHGIVEDWDLMERFMEQVVFK--YLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWT 154
Cdd:COG5277  74 PIENGIILNWDAMEQIWDYTFFNkgDLLPSPEEHPLLLTEPPLNPPSNREKITELLFETLNVPALYLAIQAVLSLYASGS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 155 SrqvgerTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIP--------PEQSLETAKA 226
Cdd:COG5277 154 S------DETGLVIDSGDSVTHVIPVVDGIVLPKAVKRIDIGGRDITDYLKKLLREKYPPSRgynlkselVEYSSEIVNE 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 227 IKEKYC-------YICPDIVREFAKYDVDPRKWIKQYTGIN----AINQKKFI------IDVGYE-RFLGPEIFFHPE-- 286
Cdd:COG5277 228 IKEEVCetddesaYVSLDAEEEFEEEEEKPAEKSTESTFQLsketSIAKESKElpdgeeIEFGNEeRFKAPEILFKPElp 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 287 ------------------FANPDFMES--------ISDVVDEVIQSCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLK 340
Cdd:COG5277 308 isgleeagkideskqelvAENYEISPTnlgndiagLPELVYQSIQICDEDVRKSLYSNIVLTGGTSKIPGFAERLQKELT 387
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394 341 rvvdarlklsqelsggRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRH 410
Cdd:COG5277 388 ----------------SLAPSIWKVSVIPPPDPSLDAWLGASILASLETFQQLWITKEEYEEHGPDILQE 441
Actin pfam00022
Actin;
6-409 7.06e-97

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 295.75  E-value: 7.06e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394     6 PPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAIRESAKVVDqaqrrvlrgvdDLDFFIGDEAIDK-PTYATKWPIRHGIVE 84
Cdd:pfam00022   2 SALVIDNGSHTTRAGFAGEDAPKAVIPSCVGKPRGTKVEA-----------ANKYYVGDEALTYrPGMEVRSPVEDGIVV 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    85 DWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIavqavlALAASWTSRQVGeRTlT 164
Cdd:pfam00022  71 DWDAMEEIWEHVLKEELQVDPEEHPLLLTEPPWNPPANREKAAEIMFEKFGVPALYL------AKNPVLSAFASG-RT-T 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   165 GIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKA------------------ 226
Cdd:pfam00022 143 GLVVDSGAGVTSVVPVHDGYVLQKAIRRSDLGGDFLTDYLRELLRSRNIEITPRYLIKSKKPgdpapavtkrelpdttys 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   227 ------------IKEKYCYICPDIVREFAKYdvdprkwikqytgiNAINQKKFI------IDVGYERFLGPEIFFHPEFA 288
Cdd:pfam00022 223 yktyqerrvleeIKESVCYVSDDPFGDETTS--------------SSIPTRVYElpdgstIILGAERFRVPEILFNPSLI 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   289 NPD-------FMESISDVVDEVIQSCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVdarlklsqeLSGGRIKPK 361
Cdd:pfam00022 289 GSEselpppqTAVGIPELIVDAINACDVDLRPSLLANIVVTGGNSLFPGFTERLEKELAQLA---------PPGVKVKII 359
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 52345394   362 PVEVQVVThhmqRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICR 409
Cdd:pfam00022 360 APGNTVER----RYSAWIGGSILASLGTFQQMWVSKQEYEEHGASVVE 403
PTZ00004 PTZ00004
actin-2; Provisional
9-407 7.35e-90

actin-2; Provisional


Pssm-ID: 240225  Cd Length: 378  Bit Score: 276.65  E-value: 7.35e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    9 VVDCGTGYTKLGYAGNTEPQFIIPSCiairesakVVDQAQRRVLRGVDDLDFFIGDEAIDK-PTYATKWPIRHGIVEDWD 87
Cdd:PTZ00004  10 VVDNGSGMVKAGFAGDDAPRCVFPSI--------VGRPKNPGIMVGMEEKDCYVGDEAQDKrGILTLKYPIEHGIVTNWD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   88 LMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASwtsrqvgERTlTGIV 167
Cdd:PTZ00004  82 DMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETHNVPAMYVAIQAVLSLYAS-------GRT-TGIV 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  168 IDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDivrefakYDV 247
Cdd:PTZ00004 154 LDSGDGVSHTVPIYEGYSLPHAIHRLDVAGRDLTEYMMKILHERGTTFTTTAEKEIVRDIKEKLCYIALD-------FDE 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  248 DPrkwiKQYTGINAINQKKF------IIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQSCPIDVRRPLYKNVVL 321
Cdd:PTZ00004 227 EM----GNSAGSSDKYEESYelpdgtIITVGSERFRCPEALFQPSLIGKEEPPGIHELTFQSINKCDIDIRKDLYGNIVL 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  322 SGGSTMFRDFGRRLQRDLKRVVdarlklsqelsggrikPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYE 401
Cdd:PTZ00004 303 SGGTTMYRGLPERLTKELTTLA----------------PSTMKIKVVAPPERKYSVWIGGSILSSLPTFQQMWVTKEEYD 366

                 ....*.
gi 52345394  402 EYGPSI 407
Cdd:PTZ00004 367 ESGPSI 372
PTZ00281 PTZ00281
actin; Provisional
9-407 1.82e-77

actin; Provisional


Pssm-ID: 173506  Cd Length: 376  Bit Score: 244.99  E-value: 1.82e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    9 VVDCGTGYTKLGYAGNTEPQFIIPSCIA-IRESAKVVDQAQRrvlrgvddlDFFIGDEAIDKPTYAT-KWPIRHGIVEDW 86
Cdd:PTZ00281  10 VIDNGSGMCKAGFAGDDAPRAVFPSIVGrPRHTGVMVGMGQK---------DSYVGDEAQSKRGILTlKYPIEHGIVTNW 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   87 DLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASwtsrqvgERTlTGI 166
Cdd:PTZ00281  81 DDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYAS-------GRT-TGI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  167 VIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVREFakyd 246
Cdd:PTZ00281 153 VMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAEREIVRDIKEKLAYVALDFEAEM---- 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  247 vdprkwikQYTGINAINQKKF------IIDVGYERFLGPEIFFHPEFANpdfMES--ISDVVDEVIQSCPIDVRRPLYKN 318
Cdd:PTZ00281 229 --------QTAASSSALEKSYelpdgqVITIGNERFRCPEALFQPSFLG---MESagIHETTYNSIMKCDVDIRKDLYGN 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  319 VVLSGGSTMFRDFGRRLQRDLKrvvdarlklsqelsggRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKK 398
Cdd:PTZ00281 298 VVLSGGTTMFPGIADRMNKELT----------------ALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKE 361

                 ....*....
gi 52345394  399 DYEEYGPSI 407
Cdd:PTZ00281 362 EYDESGPSI 370
PTZ00466 PTZ00466
actin-like protein; Provisional
7-407 1.60e-75

actin-like protein; Provisional


Pssm-ID: 240426  Cd Length: 380  Bit Score: 239.85  E-value: 1.60e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    7 PCVVDCGTGYTKLGYAGNTEPQFIIPSCIAiRESAKvvdqaqrRVLRGVDDLDFFIGDEA-----IDKPTYatkwPIRHG 81
Cdd:PTZ00466  14 PIIIDNGTGYIKAGFAGEDVPNLVFPSYVG-RPKYK-------RVMAGAVEGNIFVGNKAeeyrgLLKVTY----PINHG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   82 IVEDWDLMERFMEQVvFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSrqvger 161
Cdd:PTZ00466  82 IIENWNDMENIWIHV-YNSMKINSEEHPVLLTEAPLNPQKNKEKIAEVFFETFNVPALFISIQAILSLYSCGKT------ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  162 tlTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVRE 241
Cdd:PTZ00466 155 --NGTVLDCGDGVCHCVSIYEGYSITNTITRTDVAGRDITTYLGYLLRKNGHLFNTSAEMEVVKNMKENCCYVSFNMNKE 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  242 FAKYDvdprkwiKQYTGINAINQKKFIIDVGYERFLGPEIFFHPEFANPDFMeSISDVVDEVIQSCPIDVRRPLYKNVVL 321
Cdd:PTZ00466 233 KNSSE-------KALTTLPYILPDGSQILIGSERYRAPEVLFNPSILGLEYL-GLSELIVTSITRADMDLRRTLYSHIVL 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  322 SGGSTMFRDFGRRLQRDLKrvvdarlklsqelsggRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYE 401
Cdd:PTZ00466 305 SGGTTMFHGFGDRLLNEIR----------------KFAPKDITIRISAPPERKFSTFIGGSILASLATFKKIWISKQEFD 368

                 ....*.
gi 52345394  402 EYGPSI 407
Cdd:PTZ00466 369 EYGSVI 374
PTZ00452 PTZ00452
actin; Provisional
1-407 2.60e-57

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 192.66  E-value: 2.60e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394    1 MAGSLPPCVVDCGTGYTKLGYAGNTEPQFIIPSCIAiresakvvDQAQRRVLRGVDDLDFFIGDEA-IDKPTYATKWPIR 79
Cdd:PTZ00452   1 MQAQYPAVVIDNGSGYCKIGIAGDDAPTSCFPAIVG--------RSKQNDGIFSTFNKEYYVGEEAqAKRGVLAIKEPIQ 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   80 HGIVEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSrqvg 159
Cdd:PTZ00452  73 NGIINSWDDIEIIWHHAFYNELCMSPEDQPVFMTDAPMNSKFNRERMTQIMFETFNTPCLYISNEAVLSLYTSGKT---- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  160 ertlTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICpdiv 239
Cdd:PTZ00452 149 ----IGLVVDSGEGVTHCVPVFEGHQIPQAITKINLAGRLCTDYLTQILQELGYSLTEPHQRIIVKNIKERLCYTA---- 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  240 refakydVDPRKWIKQYTGINAINQ-----KKFIIDVGYERFLGPEIFFHPEFANPDfMESISDVVDEVIQSCPIDVRRP 314
Cdd:PTZ00452 221 -------LDPQDEKRIYKESNSQDSpyklpDGNILTIKSQKFRCSEILFQPKLIGLE-VAGIHHLAYSSIKKCDLDLRQE 292
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  315 LYKNVVLSGGSTMFRDFGRRLQRDLKRVVDARLKlsqelsggrikpkpveVQVVTHHMQRYAVWFGGSMLAS----TPEF 390
Cdd:PTZ00452 293 LCRNIVLSGGTTLFPGIANRLSNELTNLVPSQLK----------------IQVAAPPDRRFSAWIGGSIQCTlstqQPQW 356
                        410
                 ....*....|....*..
gi 52345394  391 FQvchtKKDYEEYGPSI 407
Cdd:PTZ00452 357 IK----RQEYDEQGPSI 369
NBD_sugar-kinase_HSP70_actin cd00012
Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily ...
9-196 9.61e-11

Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; This superfamily includes the actin family, the HSP70 family of molecular chaperones and nucleotide exchange factors, the ROK (repressor, ORF, kinase) family, the hexokinase family, the FGGY family (which includes glycerol kinase and similar carbohydrate kinases such as rhamnulokinase and xylulokinase), the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase/nucleoside triphosphate diphosphohydrolase family, propionate kinase/acetate kinase family, glycerol dehydratase reactivase, 2-hydroxyglutaryl-CoA dehydratase component A, N-acetylglucosamine kinase, butyrate kinase 2, Escherichia coli YeaZ and similar glycoproteases, the cell shape-determining protein MreB, the plasmid DNA segregation factor ParM, cell cycle proteins FtsA, Pili assembly protein PilM, ethanolamine utilization protein EutJ, and similar proteins. The nucleotide-binding site residues are conserved; the nucleotide sits in a deep cleft formed between the two lobes of the nucleotide-binding domain (NBD). Substrate binding to superfamily members is associated with closure of this catalytic site cleft. The functional activities of several members of the superfamily, including hexokinases, actin, and HSP70s, are modulated by allosteric effectors, which may act on the cleft closure.


Pssm-ID: 212657 [Multi-domain]  Cd Length: 185  Bit Score: 60.68  E-value: 9.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394   9 VVDCGTGYTKLGYA---GNTEPQFIIPSCIAIResakvvdqaqrrvlrgvddldffigdeaidkptyatkwpirhGIVED 85
Cdd:cd00012   2 GIDIGSTSTKAGVAdldGEILPEEIVPTPVGRP------------------------------------------GAVTD 39
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52345394  86 WDLMERFMEQVVFKYLR-AEPEDHYFLMTEPPLNTPENREYL---------AEIMFESFNVPGLYIAVQAVLALAaswTS 155
Cdd:cd00012  40 LDELEEALRELLKEALRqLKSEIDAVGITEPGGVPKENREVIilpnlllipLALALEDLGGVPVAVVNDAVAAAL---AE 116
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 52345394 156 RQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIA 196
Cdd:cd00012 117 GLFGKEEDTVLVVDLGTGTTGIAIVEDGKGGVGAAGELGIA 157
FtsA COG0849
Cell division ATPase FtsA [Cell cycle control, cell division, chromosome partitioning];
160-231 9.15e-03

Cell division ATPase FtsA [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 223918 [Multi-domain]  Cd Length: 418  Bit Score: 37.98  E-value: 9.15e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52345394 160 ERTLTGIVIDSGDGVTHVIPVAEGYVIGscIKHIPIAGRDITYFIQQLLRerevgippeQSLETAKAIKEKY 231
Cdd:COG0849 200 EKELGVALIDIGGGTTDIAIYKNGALRY--TGVIPVGGDHVTKDIAKGLK---------TPFEEAERIKIKY 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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